DE60001983T2 - Bicyclische und tricyclische heteroaromatische verbindungen - Google Patents
Bicyclische und tricyclische heteroaromatische verbindungen Download PDFInfo
- Publication number
- DE60001983T2 DE60001983T2 DE60001983T DE60001983T DE60001983T2 DE 60001983 T2 DE60001983 T2 DE 60001983T2 DE 60001983 T DE60001983 T DE 60001983T DE 60001983 T DE60001983 T DE 60001983T DE 60001983 T2 DE60001983 T2 DE 60001983T2
- Authority
- DE
- Germany
- Prior art keywords
- sub
- compounds
- bicyclic
- heteroaromatic compounds
- tricyclic heteroaromatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70571—Assays involving receptors, cell surface antigens or cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16505499P | 1999-11-12 | 1999-11-12 | |
PCT/US2000/030905 WO2001034603A2 (en) | 1999-11-12 | 2000-11-10 | Bicyclic and tricyclic heteroaromatic compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60001983D1 DE60001983D1 (de) | 2003-05-08 |
DE60001983T2 true DE60001983T2 (de) | 2004-01-29 |
Family
ID=22597230
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60001983T Expired - Fee Related DE60001983T2 (de) | 1999-11-12 | 2000-11-10 | Bicyclische und tricyclische heteroaromatische verbindungen |
Country Status (16)
Country | Link |
---|---|
US (4) | US6511987B1 (de) |
EP (1) | EP1228069B1 (de) |
JP (1) | JP2003513975A (de) |
KR (1) | KR20020050262A (de) |
CN (1) | CN1390217A (de) |
AT (1) | ATE236158T1 (de) |
AU (1) | AU1481701A (de) |
BR (1) | BR0015420A (de) |
CA (1) | CA2388593A1 (de) |
DE (1) | DE60001983T2 (de) |
ES (1) | ES2195943T3 (de) |
IL (1) | IL149550A0 (de) |
MX (1) | MXPA02004735A (de) |
NO (1) | NO20022185D0 (de) |
WO (1) | WO2001034603A2 (de) |
ZA (1) | ZA200203653B (de) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6511987B1 (en) | 1999-11-12 | 2003-01-28 | Neurogen Corporation | Bicyclic and tricyclic heteroaromatic compounds |
US6833377B2 (en) * | 2001-02-05 | 2004-12-21 | Gevys Pharmaceuticals Ltd. | Composition and method for potentiating drugs |
FR2823752B1 (fr) * | 2001-04-18 | 2004-10-22 | Servier Lab | Nouveaux derives de pyrimidin-4-ones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US6686352B2 (en) | 2001-05-18 | 2004-02-03 | Hoffmann-La Roche Inc. | Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives |
US6921762B2 (en) | 2001-11-16 | 2005-07-26 | Amgen Inc. | Substituted indolizine-like compounds and methods of use |
CN1802353A (zh) | 2002-12-30 | 2006-07-12 | 细胞基因公司 | 氟烷氧基取代的1,3-二氢-异吲哚化合物及其药物用途 |
WO2005025563A1 (en) * | 2003-09-12 | 2005-03-24 | Warner-Lambert Company Llc | Combination comprising an alpha-2-delta ligand and an ssri and/or snri for treatment of depression and anxiety disorders |
US7546431B2 (en) * | 2005-03-21 | 2009-06-09 | Emc Corporation | Distributed open writable snapshot copy facility using file migration policies |
PL1966214T3 (pl) | 2005-12-21 | 2017-04-28 | Janssen Pharmaceutica N.V. | Triazolopirydazyny jako modulatory kinazy tyrozynowej |
CA2633536A1 (en) * | 2005-12-27 | 2007-07-05 | F. Hoffmann-La Roche Ag | Aryl-isoxazol-4-yl-imidazo[1, 5-a]pyridine derivatives |
MX2008014796A (es) | 2006-05-31 | 2008-12-02 | Hoffmann La Roche | Derivados de aril-4-etinil-isoxazol. |
WO2008021781A1 (en) | 2006-08-07 | 2008-02-21 | Incyte Corporation | Triazolotriazines as kinase inhibitors |
JP5373613B2 (ja) | 2006-10-16 | 2013-12-18 | バイオノミクス リミテッド | 新規な抗不安薬化合物 |
US10954231B2 (en) | 2006-10-16 | 2021-03-23 | Bionomics Limited | Anxiolytic compounds |
ES2689444T3 (es) | 2006-11-22 | 2018-11-14 | Incyte Holdings Corporation | Imidazotriazinas e imidazopirimidinas como inhibidores de la quinasa |
MX2009014001A (es) | 2007-06-22 | 2010-01-28 | Hoffmann La Roche | Derivados de isoxazol-imidazol. |
US7943619B2 (en) | 2007-12-04 | 2011-05-17 | Hoffmann-La Roche Inc. | Isoxazolo-pyridazine derivatives |
US7902201B2 (en) | 2007-12-04 | 2011-03-08 | Hoffmann-La Roche Inc. | Isoxazolo-pyrazine derivatives |
JP5301556B2 (ja) | 2007-12-04 | 2013-09-25 | エフ.ホフマン−ラ ロシュ アーゲー | イソオキサゾロ−ピラジン誘導体 |
WO2009082691A1 (en) * | 2007-12-21 | 2009-07-02 | Board Of Regents, University Of Texas System | Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity |
BRPI0912882A2 (pt) | 2008-05-21 | 2017-05-16 | Incyte Corp | sais de 2-flúor-n-metil-4-[7-(quinolin-6-il-metil)-imidazo[1,2-b][1,2,4]triazin-2-il]benzamida e processos relacionados à preparação dos mesmos |
WO2010022081A1 (en) | 2008-08-19 | 2010-02-25 | Array Biopharma Inc. | Triazolopyridine compounds as pim kinase inhibitors |
US8895550B2 (en) | 2008-08-19 | 2014-11-25 | Array Biopharma Inc. | Triazolopyridine compounds as PIM kinase inhibitors |
TWI496779B (zh) | 2008-08-19 | 2015-08-21 | Array Biopharma Inc | 作為pim激酶抑制劑之***吡啶化合物 |
TW201033201A (en) | 2009-02-19 | 2010-09-16 | Hoffmann La Roche | Isoxazole-isoxazole and isoxazole-isothiazole derivatives |
US8389550B2 (en) | 2009-02-25 | 2013-03-05 | Hoffmann-La Roche Inc. | Isoxazoles / O-pyridines with ethyl and ethenyl linker |
US8222246B2 (en) | 2009-04-02 | 2012-07-17 | Hoffmann-La Roche Inc. | Substituted isoxazoles |
US8227461B2 (en) | 2009-04-30 | 2012-07-24 | Hoffmann-La Roche Inc. | Isoxazoles |
MX2011011477A (es) | 2009-05-05 | 2011-11-18 | Hoffmann La Roche | Derivados de isoxazol-piridazina. |
SG175869A1 (en) | 2009-05-05 | 2011-12-29 | Hoffmann La Roche | Isoxazole-thiazole derivatives as gaba a receptor inverse agonists for use in the treatment of cognitive disorders |
MX2011011489A (es) | 2009-05-05 | 2011-11-18 | Hoffmann La Roche | Derivados de isoxazol-piridina. |
MX2011011273A (es) | 2009-05-05 | 2011-11-04 | Hoffmann La Roche | Derivados de isoxazol-pirazol. |
SG175318A1 (en) | 2009-05-07 | 2011-11-28 | Hoffmann La Roche | Isoxazole-pyridine derivatives as gaba modulators |
US8487096B2 (en) | 2010-02-03 | 2013-07-16 | Incyte Corporation | Imidazo[1,2-B][1,2,4]triazines as C-MET inhibitors |
DK2678329T3 (da) | 2011-02-25 | 2016-02-22 | Array Biopharma Inc | Triazolopyridinforbindelser som pim-kinase-hæmmere |
CA2828780A1 (en) | 2011-03-02 | 2012-09-07 | Bionomics Limited | Novel small-molecules as therapeutics |
US9133188B2 (en) | 2011-05-12 | 2015-09-15 | Bionomics Limited | Methods for preparing naphthyridines |
US8785435B2 (en) | 2011-10-20 | 2014-07-22 | Hoffmann-La Roche Inc. | Solid forms |
US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
CN106854207B (zh) | 2015-12-08 | 2019-10-29 | 上海赛默罗生物科技有限公司 | 呔嗪类衍生物、其制备方法、药物组合物和用途 |
WO2019174577A1 (zh) * | 2018-03-12 | 2019-09-19 | 上海赛默罗生物科技有限公司 | 酞嗪异噁唑烷氧基衍生物、其制备方法、药物组合物和用途 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1194310B (it) * | 1983-07-12 | 1988-09-14 | Lepetit Spa | Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti |
IT1270615B (it) | 1994-07-14 | 1997-05-07 | Smithkline Beecham Farma | Uso di derivati di chinolina |
US5955465A (en) | 1996-03-22 | 1999-09-21 | Neurogen Corporation | 1,2,4-triazolo 4,3-c!quinazolin-3-ones and 1,2,4-triazolo 4,3-c!quinazolin-3-thiones |
GB9715977D0 (en) | 1997-07-29 | 1997-10-01 | Merck Sharp & Dohme | Therapeutic agents |
US6297235B1 (en) | 1997-08-28 | 2001-10-02 | Merck Sharp & Dohme Ltd. | Triazolopyridazine derivatives for treating anxiety and enhancing cognition |
US6303597B1 (en) | 1998-01-14 | 2001-10-16 | Merck Sharp & Dohme Limited | Triazolo-pyridazine derivatives as ligands for GABA receptors |
AU3371099A (en) | 1998-03-30 | 1999-10-18 | President And Fellows Of Harvard College | Regulation of glycosaminoglycan synthesis, methods and reagents related thereto |
EP1165542B1 (de) * | 1999-03-29 | 2003-08-20 | Neurogen Corporation | 4-substituierte chinolinderivate als nk-3 und/oder gaba(a) rezeptor liganden |
US6511987B1 (en) | 1999-11-12 | 2003-01-28 | Neurogen Corporation | Bicyclic and tricyclic heteroaromatic compounds |
-
2000
- 2000-11-10 US US09/709,887 patent/US6511987B1/en not_active Expired - Fee Related
- 2000-11-10 BR BR0015420-2A patent/BR0015420A/pt not_active Application Discontinuation
- 2000-11-10 WO PCT/US2000/030905 patent/WO2001034603A2/en active IP Right Grant
- 2000-11-10 JP JP2001536550A patent/JP2003513975A/ja not_active Withdrawn
- 2000-11-10 AU AU14817/01A patent/AU1481701A/en not_active Abandoned
- 2000-11-10 IL IL14955000A patent/IL149550A0/xx unknown
- 2000-11-10 KR KR1020027005947A patent/KR20020050262A/ko not_active Application Discontinuation
- 2000-11-10 EP EP00977138A patent/EP1228069B1/de not_active Expired - Lifetime
- 2000-11-10 MX MXPA02004735A patent/MXPA02004735A/es active IP Right Grant
- 2000-11-10 ES ES00977138T patent/ES2195943T3/es not_active Expired - Lifetime
- 2000-11-10 AT AT00977138T patent/ATE236158T1/de not_active IP Right Cessation
- 2000-11-10 CN CN00815483A patent/CN1390217A/zh active Pending
- 2000-11-10 DE DE60001983T patent/DE60001983T2/de not_active Expired - Fee Related
- 2000-11-10 CA CA002388593A patent/CA2388593A1/en not_active Abandoned
-
2002
- 2002-05-07 NO NO20022185A patent/NO20022185D0/no not_active Application Discontinuation
- 2002-05-08 ZA ZA200203653A patent/ZA200203653B/en unknown
-
2003
- 2003-01-28 US US10/352,519 patent/US7053093B2/en not_active Expired - Fee Related
-
2006
- 2006-05-30 US US11/442,812 patent/US7326709B2/en not_active Expired - Fee Related
-
2008
- 2008-02-04 US US12/025,490 patent/US20080146546A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DE60001983D1 (de) | 2003-05-08 |
US6511987B1 (en) | 2003-01-28 |
US20060217384A1 (en) | 2006-09-28 |
MXPA02004735A (es) | 2003-01-28 |
CN1390217A (zh) | 2003-01-08 |
WO2001034603A3 (en) | 2002-01-10 |
EP1228069A2 (de) | 2002-08-07 |
US20080146546A1 (en) | 2008-06-19 |
KR20020050262A (ko) | 2002-06-26 |
NO20022185L (no) | 2002-05-07 |
US7053093B2 (en) | 2006-05-30 |
AU1481701A (en) | 2001-06-06 |
BR0015420A (pt) | 2002-07-16 |
NO20022185D0 (no) | 2002-05-07 |
US7326709B2 (en) | 2008-02-05 |
EP1228069B1 (de) | 2003-04-02 |
IL149550A0 (en) | 2002-11-10 |
ATE236158T1 (de) | 2003-04-15 |
CA2388593A1 (en) | 2001-05-17 |
WO2001034603A2 (en) | 2001-05-17 |
ZA200203653B (en) | 2003-04-10 |
ES2195943T3 (es) | 2003-12-16 |
JP2003513975A (ja) | 2003-04-15 |
US20030181455A1 (en) | 2003-09-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |