DE414854C - Process for the production of organic bismuth compounds - Google Patents
Process for the production of organic bismuth compoundsInfo
- Publication number
- DE414854C DE414854C DEC33440D DEC0033440D DE414854C DE 414854 C DE414854 C DE 414854C DE C33440 D DEC33440 D DE C33440D DE C0033440 D DEC0033440 D DE C0033440D DE 414854 C DE414854 C DE 414854C
- Authority
- DE
- Germany
- Prior art keywords
- bismuth
- production
- bismuth compounds
- salts
- organic bismuth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004519 manufacturing process Methods 0.000 title claims description 4
- 150000001622 bismuth compounds Chemical class 0.000 title description 3
- 238000000034 method Methods 0.000 title description 3
- VZYDKJOUEPFKMW-UHFFFAOYSA-N 2,3-dihydroxybenzenesulfonic acid Chemical class OC1=CC=CC(S(O)(=O)=O)=C1O VZYDKJOUEPFKMW-UHFFFAOYSA-N 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 150000003460 sulfonic acids Chemical class 0.000 claims description 3
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- -1 alkali metal salts Chemical class 0.000 claims 1
- 229910052797 bismuth Inorganic materials 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 239000003513 alkali Substances 0.000 description 3
- 150000001447 alkali salts Chemical class 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 150000007513 acids Chemical class 0.000 description 2
- 229940049676 bismuth hydroxide Drugs 0.000 description 2
- TZSXPYWRDWEXHG-UHFFFAOYSA-K bismuth;trihydroxide Chemical compound [OH-].[OH-].[OH-].[Bi+3] TZSXPYWRDWEXHG-UHFFFAOYSA-K 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 150000001621 bismuth Chemical class 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- RXPAJWPEYBDXOG-UHFFFAOYSA-N hydron;methyl 4-methoxypyridine-2-carboxylate;chloride Chemical compound Cl.COC(=O)C1=CC(OC)=CC=N1 RXPAJWPEYBDXOG-UHFFFAOYSA-N 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 235000011121 sodium hydroxide Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- RBWFXUOHBJGAMO-UHFFFAOYSA-N sulfanylidenebismuth Chemical compound [Bi]=S RBWFXUOHBJGAMO-UHFFFAOYSA-N 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/94—Bismuth compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur Herstellung von organischen Wismutverbindungen. Durch das Hauptpatent413778 ist ein Verfahren zur Darstellung von Wismutkomplexverbindungen von Brenzcatechinsulfosäuren geschützt, "welches darin besteht, daß man entweder Brenzcatechinsulfosäuren mit Wismuthvdroxvd behandelt oder die Alkalisalze der Stilfosäuren mit Wismutsalzen umsetzt und die so erhaltenen Produkte mit Allalilauge neutralisiert oder von vornherein die Alkalisalze von Brenzcatechinsulfosäuren auf Wismuthydroxy d einwirken läßt.Process for the production of organic bismuth compounds. By main patent 413778 is a method for the preparation of bismuth complex compounds protected by catechol sulfonic acids, "which consists in having either Catechol sulphonic acids treated with bismuth vdroxvd or the alkali salts of the stilfo acids reacted with bismuth salts and the products thus obtained are neutralized with alumina solution or from the outset the alkali salts of catechol sulfonic acids on bismuth hydroxy d can act.
Es wurde nun gefunden, daß Komplexverbindungen von ähnlichen Eigenschaften hergestellt werden könne-i, wenn man in analoger Weise Sulfosäuren der o-Dioxynaphthaline mit Wismutverbindungen umsetzt.It has now been found that complex compounds of similar properties Can be prepared if sulfonic acids of the o-dioxynaphthalenes are used in an analogous manner implemented with bismuth compounds.
Die Herstellung solcher Produkte erfolgt auch hier in der Weise, daß man Wismuthy droxyd oder dessen Derivate auf Sulfosäuren der o-Dioxynaphthaline oder deren Salze einwirken läßt. Zur Herstellung der Alkalisalze verwendet man so viel Alkalilauge, daß die Lösung neutral oder schwach alkalisch reagiert, und scheidet die Salze durch Eindampfen oder Ausfällen mit organischen Lösungsmitteln in fester Form ab. Man kann auch unmittelbar Wismuthydroxyd in Lösungen der Salze der genannten Sulfosäuren auflt:seii unter Zufügen von so viel Alkali, daß die Reaktion am Schluß nahezu neutral oder schwach alkalisch ist.The manufacture of such products takes place here in such a way that one Bismuthy droxyd or its derivatives on sulfonic acids of the o-dioxynaphthalenes or lets their salts take effect. This is used to produce the alkali salts a lot of alkali that the solution reacts neutrally or slightly alkaline, and separates the salts by evaporation or precipitation with organic solvents in solid Shape. Bismuth hydroxide can also be used directly in solutions of the salts mentioned Sulphonic acids are dissolved: be it with the addition of so much alkali that the reaction ends at the end is almost neutral or slightly alkaline.
Die neuen Produkte sollen therapeutischen Zwecken dienen; der aromatische Teil des :Moleküls hat außer seiner Funktion, das Wismut komplex in Lösung zu halten, noch einen besonderen Anteil an der therapeutischen Wirkung. Beispiel: 38 g r,2-dioxynaphthalin-3,6-disulfonsaures Ammonium-N'atriuin werden in 400 ccm Wasser gelöst und zu der erwärmten Lösung eine Suspension von Wismuthydroxyd gegeben, welche man aus 4o g Wismutnitrat durch Behandeln mit Alkali und Auswaschen hergestellt hat. Man fügt 'Natronlauge bis etwa zum neutralen Punkt hinzu, filtriert und engt das dunkelgrüne Filtrat ein. Durch völliges Eindampfen oder z. B. Ausfällen mit Methylalkohol, wobei man gegebenenfalls vorher nochmals filtriert, erhält man die neue Komplexverbindung. Getrocknet ist sie ein grünes Pulver, das sich leicht in Wasser löst. Aus der wässerigen Lösung fällt, wenn man Schwefelwasserstoff einleitet, Schwefelwismut aus. Man kann Verbindungen mit verschiedenem, insbesondere auch höherem Wismutgehalt erhalten.The new products are intended to serve therapeutic purposes; the aromatic one Part of: In addition to its function, the molecule has to keep the bismuth complex in solution, still play a special role in the therapeutic effect. Example: 38 g r, 2-dioxynaphthalene-3,6-disulfonic acid Ammonium N'atriuin are dissolved in 400 ccm of water and add to the heated solution Suspension of bismuth hydroxide given, which is obtained from 40 g of bismuth nitrate by treatment made with alkali and washout. Add caustic soda to about neutral Add point, filtered and concentrated the dark green filtrate. By complete evaporation or z. B. Precipitation with methyl alcohol, if necessary again beforehand filtered, the new complex compound is obtained. When dried it is a green one Powder that easily dissolves in water. Falls out of the aqueous solution when one Hydrogen sulphide introduces, bismuth sulphide out. One can make connections with different, in particular also get a higher bismuth content.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEC33440D DE414854C (en) | 1922-10-21 | 1923-04-18 | Process for the production of organic bismuth compounds |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEC32757D DE413778C (en) | 1922-10-21 | 1922-10-21 | Process for the production of organic bismuth compounds |
| DEC33440D DE414854C (en) | 1922-10-21 | 1923-04-18 | Process for the production of organic bismuth compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE414854C true DE414854C (en) | 1925-06-09 |
Family
ID=25969859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEC33440D Expired DE414854C (en) | 1922-10-21 | 1923-04-18 | Process for the production of organic bismuth compounds |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE414854C (en) |
-
1923
- 1923-04-18 DE DEC33440D patent/DE414854C/en not_active Expired
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