DE3883522D1 - Verfahren zum diagnostizieren von blutpfropfen mit fibrin-bindenden proteinen. - Google Patents

Verfahren zum diagnostizieren von blutpfropfen mit fibrin-bindenden proteinen.

Info

Publication number
DE3883522D1
DE3883522D1 DE88909689T DE3883522T DE3883522D1 DE 3883522 D1 DE3883522 D1 DE 3883522D1 DE 88909689 T DE88909689 T DE 88909689T DE 3883522 T DE3883522 T DE 3883522T DE 3883522 D1 DE3883522 D1 DE 3883522D1
Authority
DE
Germany
Prior art keywords
diagnosticing
fibrine
binding proteins
plugs
blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE88909689T
Other languages
English (en)
Other versions
DE3883522T2 (de
Inventor
Stephen Hadley
Marjorie Mohler
John Reno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Poniard Pharmaceuticals Inc
Original Assignee
Genentech Inc
Poniard Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc, Poniard Pharmaceuticals Inc filed Critical Genentech Inc
Priority claimed from PCT/US1988/003318 external-priority patent/WO1989002752A1/en
Publication of DE3883522D1 publication Critical patent/DE3883522D1/de
Application granted granted Critical
Publication of DE3883522T2 publication Critical patent/DE3883522T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/28—Bound to a nonpeptide drug, nonpeptide label, nonpeptide carrier, or a nonpeptide resin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE88909689T 1987-09-25 1988-09-26 Verfahren zum diagnostizieren von blutpfropfen mit fibrin-bindenden proteinen. Expired - Fee Related DE3883522T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10132987A 1987-09-25 1987-09-25
US07/247,973 US5217705A (en) 1987-09-25 1988-09-22 Method of diagnosing blood clots using fibrin-binding proteins
PCT/US1988/003318 WO1989002752A1 (en) 1987-09-25 1988-09-26 Method of diagnosing blood clots using fibrin-binding proteins

Publications (2)

Publication Number Publication Date
DE3883522D1 true DE3883522D1 (de) 1993-09-30
DE3883522T2 DE3883522T2 (de) 1994-03-24

Family

ID=26798134

Family Applications (1)

Application Number Title Priority Date Filing Date
DE88909689T Expired - Fee Related DE3883522T2 (de) 1987-09-25 1988-09-26 Verfahren zum diagnostizieren von blutpfropfen mit fibrin-bindenden proteinen.

Country Status (5)

Country Link
US (1) US5217705A (de)
EP (1) EP0342215B1 (de)
JP (1) JP2801236B2 (de)
AU (1) AU2612888A (de)
DE (1) DE3883522T2 (de)

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US5972890A (en) * 1988-05-02 1999-10-26 New England Deaconess Hospital Corporation Synthetic peptides for arterial imaging
DK0570493T3 (da) * 1991-02-08 2000-06-26 Diatide Inc Technetium-99m-mærkede polypeptider til billeddannelse.
US5968476A (en) * 1992-05-21 1999-10-19 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US5750088A (en) 1993-03-30 1998-05-12 The Dupont Merck Pharmaceutical Company Stable hydrazones linked to a peptide moiety as reagents for the preparation of radiopharmaceuticals
CA2095569A1 (en) * 1993-05-04 1994-11-06 Sidney P. Butler Composition and method
US5561146A (en) * 1994-06-10 1996-10-01 Bristol-Myers Squibb Company Modified guanidino and amidino thrombin inhibitors
AU3532197A (en) * 1997-07-24 1999-02-16 Australian National University, The Method for detection of fibrin clots
US7056504B1 (en) 1998-08-27 2006-06-06 Massachusetts Institute Of Technology Rationally designed heparinases derived from heparinase I and II
US6314314B1 (en) * 1999-01-14 2001-11-06 Seth J. Karp Method for locating an internal bleeding site in a human body
US6808698B1 (en) 1999-03-26 2004-10-26 Bristol-Myers Squibb Pharma Company Method for localization of blood clots
US6254852B1 (en) 1999-07-16 2001-07-03 Dupont Pharmaceuticals Company Porous inorganic targeted ultrasound contrast agents
US6685914B1 (en) * 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
JP2003525946A (ja) 2000-03-08 2003-09-02 マサチューセッツ インスティテュート オブ テクノロジー ヘパリナーゼｉｉｉおよびその使用
US7160540B2 (en) * 2000-06-30 2007-01-09 Regents Of The University Of Minnesota Methods for detecting activity of clottings factors
US20030211094A1 (en) 2001-06-26 2003-11-13 Nelsestuen Gary L. High molecular weight derivatives of vitamin k-dependent polypeptides
US6423826B1 (en) 2000-06-30 2002-07-23 Regents Of The University Of Minnesota High molecular weight derivatives of vitamin K-dependent polypeptides
ES2324701T3 (es) 2000-09-12 2009-08-13 Massachusetts Institute Of Technology Metodos y productos relacionados con heparina de peso molecular bajo.
US6506365B1 (en) * 2000-09-25 2003-01-14 Baxter Aktiengesellschaft Fibrin/fibrinogen binding conjugate
AU2002224408B2 (en) 2000-10-18 2007-08-23 Massachusetts Institute Of Technology Methods and products related to pulmonary delivery of polysaccharides
US20030069187A1 (en) * 2001-10-05 2003-04-10 Rao Srinivasa K. Elastase inhibitors
US7317104B2 (en) 2003-06-13 2008-01-08 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
US7319149B2 (en) * 2003-06-13 2008-01-15 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
US20060024229A1 (en) * 2004-07-29 2006-02-02 Seth Karp Method and product for locating an internal bleeding site
GB0524987D0 (en) * 2005-12-08 2006-01-18 Ge Healthcare Ltd Novel imaging agents for fibrosis
US20080167544A1 (en) * 2006-12-01 2008-07-10 Cold Spring Diagnostics, Inc. Compositions And Methods For Locating An Internal Bleeding Site
US9814672B2 (en) * 2007-03-09 2017-11-14 Susan T. Laing Echogenic vehicle for clinical delivery of plasminogen activator and other fibrin-binding therapeutics to thrombi
US20090317330A2 (en) * 2007-12-21 2009-12-24 Baker Idi Heart And Diabetes Institute Holdings Limited Diagnosis and treatment of diseases involving platelet activation
JP2014521462A (ja) 2011-08-05 2014-08-28 シルク・ロード・メディカル・インコーポレイテッド 急性虚血性脳卒中を治療するための方法及びシステム
US9265512B2 (en) 2013-12-23 2016-02-23 Silk Road Medical, Inc. Transcarotid neurovascular catheter
CA2983072A1 (en) 2015-02-04 2016-08-11 Route 92 Medical, Inc. Rapid aspiration thrombectomy system and method
US11065019B1 (en) 2015-02-04 2021-07-20 Route 92 Medical, Inc. Aspiration catheter systems and methods of use
WO2017019563A1 (en) 2015-07-24 2017-02-02 Route 92 Medical, Inc. Anchoring delivery system and methods
WO2017147493A1 (en) 2016-02-24 2017-08-31 Incept, Llc Enhanced flexibility neurovascular catheter
CA3023227C (en) * 2016-05-06 2021-11-02 Biodynamic Research Foundation Pharmaceutical composition containing macromolecular drug
JP7264581B2 (ja) 2017-01-06 2023-04-25 インセプト、リミテッド、ライアビリティ、カンパニー 動脈瘤治療装置向けの抗血栓性コーティング
WO2018132387A1 (en) 2017-01-10 2018-07-19 Route 92 Medical, Inc. Aspiration catheter systems and methods of use
AU2019262972A1 (en) 2018-05-01 2020-10-15 Incept, Llc Devices and methods for removing obstructive material from an intravascular site
US11395665B2 (en) 2018-05-01 2022-07-26 Incept, Llc Devices and methods for removing obstructive material, from an intravascular site
EP3793660A2 (de) 2018-05-17 2021-03-24 Route 92 Medical, Inc. Aspirationskathetersysteme und verfahren zur verwendung
US11517335B2 (en) 2018-07-06 2022-12-06 Incept, Llc Sealed neurovascular extendable catheter
US11471582B2 (en) 2018-07-06 2022-10-18 Incept, Llc Vacuum transfer tool for extendable catheter
US11766539B2 (en) 2019-03-29 2023-09-26 Incept, Llc Enhanced flexibility neurovascular catheter
WO2021076642A1 (en) 2019-10-15 2021-04-22 Imperative Care, Inc. Systems and methods for multivariate stroke detection
US20210315598A1 (en) 2019-12-18 2021-10-14 Imperative Care, Inc. Methods of placing large bore aspiration catheters
EP4076611A4 (de) 2019-12-18 2023-11-15 Imperative Care, Inc. Verfahren und systeme zur behandlung venöser thromboembolischer erkrankungen
US11638637B2 (en) 2019-12-18 2023-05-02 Imperative Care, Inc. Method of removing embolic material with thrombus engagement tool
JP2023517575A (ja) 2020-03-10 2023-04-26 インパラティブ、ケア、インク． 可撓性を増強した神経血管カテーテル
US11207497B1 (en) 2020-08-11 2021-12-28 Imperative Care, Inc. Catheter with enhanced tensile strength

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US4416865A (en) * 1973-02-20 1983-11-22 Research Corporation Radiopharmaceuticals for localization of thromboembolic disease
US4381346A (en) * 1979-11-13 1983-04-26 Huasin Syed S Isolation of plasminogen activators useful as therapeutic and diagnostic agents
JPS56125317A (en) * 1980-03-08 1981-10-01 Nippon Mejifuijitsukusu Kk Stable radioactive diagnosticum with radioactive metallic mark
US4318904A (en) * 1980-04-25 1982-03-09 Research Corporation Peptide affinity labels for thrombin and other trypsin-like proteases
US4418052A (en) * 1980-08-12 1983-11-29 Wong Dennis W Diagnostic compositions and method for radiologic imaging of fibrinogen deposition in the body
US4427646A (en) * 1981-04-02 1984-01-24 Research Corporation Use of radiolabeled peptide derived from crosslinked fibrin to locate thrombi in vivo
EP0125269A1 (de) * 1982-11-11 1984-11-21 Beecham Group Plc Pharmazeutisch aktive verbindungen
US4741900A (en) * 1982-11-16 1988-05-03 Cytogen Corporation Antibody-metal ion complexes
US4663146A (en) * 1983-07-29 1987-05-05 Codon Genetic Engineering Laboratories Methods and compositions for the diagnosis of bloodclots using plasminogen activator
GB8334499D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Derivatives
CA1313488C (en) * 1986-03-12 1993-02-09 Adair John Hotchkiss Assay
US4913891A (en) * 1986-04-17 1990-04-03 The United States Of America As Represented By The United States Department Of Energy Positron emitter labeled enzyme inhibitors
US4861869A (en) * 1986-05-29 1989-08-29 Mallinckrodt, Inc. Coupling agents for joining radionuclide metal ions with biologically useful proteins
CA1339445C (en) * 1986-11-12 1997-09-09 The General Hospital Corporation Recombinant hybrid immunoglobulin molecules and method of use

Also Published As

Publication number Publication date
JPH02502014A (ja) 1990-07-05
EP0342215B1 (de) 1993-08-25
US5217705A (en) 1993-06-08
JP2801236B2 (ja) 1998-09-21
EP0342215A1 (de) 1989-11-23
AU2612888A (en) 1989-04-18
DE3883522T2 (de) 1994-03-24

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee