DE3851268T2 - Zyklische Peptolide. - Google Patents

Zyklische Peptolide.

Info

Publication number: DE3851268T2
Authority: DE; Germany
Prior art keywords: peptolides; cyclic; cyclic peptolides; undecapeptide; cyclisation
Prior art date: 1987-06-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE3851268T

Other languages

English (en)

Other versions

DE3851268D1 (de

Inventor

Michael Morris Dreyfuss

Max H Schreier

Hans Tscherter

Roland Wenger

Alexander Dr Haslberger

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novartis AG

Original Assignee

Sandoz AG

Sandoz Patent GmbH

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-06-19

Filing date

1988-06-15

Publication date

1995-01-26

1988-06-15 Application filed by Sandoz AG, Sandoz Patent GmbH filed Critical Sandoz AG

1994-10-06 Application granted granted Critical

1994-10-06 Publication of DE3851268D1 publication Critical patent/DE3851268D1/de

1995-01-26 Publication of DE3851268T2 publication Critical patent/DE3851268T2/de

2008-06-16 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

125000004122 cyclic group Chemical group 0.000 title abstract 3
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 abstract 1
229930105110 Cyclosporin A Natural products 0.000 abstract 1
108010036949 Cyclosporine Proteins 0.000 abstract 1
241001264173 Cylindrotrichum Species 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
230000002141 anti-parasite Effects 0.000 abstract 1
229960001265 ciclosporin Drugs 0.000 abstract 1
229930182912 cyclosporin Natural products 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
230000004151 fermentation Effects 0.000 abstract 1
238000000855 fermentation Methods 0.000 abstract 1
230000002538 fungal effect Effects 0.000 abstract 1
230000001506 immunosuppresive effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Zoology (AREA)
Biotechnology (AREA)
Wood Science & Technology (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Virology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
General Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Botany (AREA)
Mycology (AREA)
Chemical Kinetics & Catalysis (AREA)
Tropical Medicine & Parasitology (AREA)
Public Health (AREA)
Biomedical Technology (AREA)
Microbiology (AREA)
Transplantation (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DE3851268T 1987-06-19 1988-06-15 Zyklische Peptolide. Expired - Lifetime DE3851268T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH231787		1987-06-19
CH251787		1987-07-02

Publications (2)

Publication Number	Publication Date
DE3851268D1 DE3851268D1 (de)	1994-10-06
DE3851268T2 true DE3851268T2 (de)	1995-01-26

Family

ID=25690129

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE3851268T Expired - Lifetime DE3851268T2 (de)	1987-06-19	1988-06-15	Zyklische Peptolide.

Country Status (17)

Country	Link
US (1)	US5116816A (de)
EP (1)	EP0296123B1 (de)
JP (1)	JP2641256B2 (de)
KR (1)	KR970010928B1 (de)
AT (1)	ATE110784T1 (de)
AU (1)	AU623078B2 (de)
CA (1)	CA1338183C (de)
DE (1)	DE3851268T2 (de)
ES (1)	ES2056954T3 (de)
FI (1)	FI87928C (de)
HU (1)	HU204101B (de)
IE (1)	IE64008B1 (de)
IL (1)	IL86789A (de)
MY (1)	MY103735A (de)
NZ (1)	NZ225071A (de)
PH (1)	PH25933A (de)
PT (1)	PT87763B (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU213553B (en) *	1992-05-25	1997-07-28	Biogal Gyogyszergyar	Process for isolating of cyclosporin-a
JP3480848B2 (ja) *	1992-06-19	2003-12-22	タカラバイオ株式会社	環状ペプチドの合成方法
US5260215A (en) *	1992-07-20	1993-11-09	Merck & Co., Inc.	Fungal microorganism ATCC 74167 capable of producing cholesterol lowering compounds
US6187547B1 (en)	1993-09-08	2001-02-13	Novartis Ag	Assay kit
NZ291168A (en) *	1994-07-27	1998-06-26	Novartis Ag	Cyclopeptolides which inhibit expression of adhesion molecules (icam-1, vcam and e-selectin)
JP3089350B2 (ja) *	1995-11-20	2000-09-18	ギルフォードファーマシューティカルズインコーポレイテッド	シクロフィリンロタマーゼ活性の阻害剤
US5858401A (en)	1996-01-22	1999-01-12	Sidmak Laboratories, Inc.	Pharmaceutical composition for cyclosporines
US5709797A (en) *	1996-06-05	1998-01-20	Poli Industria Chimica S.P.A.	Method of isolating cyclosporins
CN1130373C (zh) *	1996-09-13	2003-12-10	诺瓦蒂斯有限公司	[3'－脱氧－3'－氧代－MeBmt]'环孢菌素制备方法
ATE423130T1 (de)	1997-10-08	2009-03-15	Isotechnika Inc	Deuterierte cyclosporin-analoga und ihre verwendung als immunmodulierende agenzien
US20030220234A1 (en) *	1998-11-02	2003-11-27	Selvaraj Naicker	Deuterated cyclosporine analogs and their use as immunodulating agents
JP2003508512A (ja)	1999-09-08	2003-03-04	ギルフォードファーマシュウティカルズインコーポレイテッド	非ペプチド性サイクロフィリン結合化合物とその用途
US6656971B2 (en)	2001-01-25	2003-12-02	Guilford Pharmaceuticals Inc.	Trisubstituted carbocyclic cyclophilin binding compounds and their use
US6593362B2 (en)	2001-05-21	2003-07-15	Guilford Pharmaceuticals Inc.	Non-peptidic cyclophilin binding compounds and their use
US20040147433A1 (en) *	2001-06-14	2004-07-29	Marcus Keep	Neuroimmunophilins for selective neuronal radioprotection
DK1435910T3 (da) *	2001-10-19	2009-11-09	Isotechnika Inc	Nye cyclosporinanaloge mikroemulsionsprækoncentrater
CA2461740C (en)	2001-10-19	2013-02-12	Isotechnika Inc.	Synthesis of cyclosporin analogs
EP1603512A2 (de) *	2003-03-17	2005-12-14	Albany Molecular Research, Inc.	Neue cyclosporine
WO2006039163A2 (en) *	2004-09-29	2006-04-13	Amr Technology, Inc.	Cyclosporin alkyne analogues and their pharmaceutical uses
EP1804823A4 (de) *	2004-09-29	2010-06-09	Amr Technology Inc	Neue cyclosporin-analoga und ihre pharmazeutischen anwendungen
WO2006041631A2 (en) *	2004-10-06	2006-04-20	Amr Technology, Inc.	Novel cyclosporin alkynes and their utility as pharmaceutical agents
WO2006054801A1 (en) *	2004-11-22	2006-05-26	Astellas Pharma Inc.	New cyclic peptide compound
US7696165B2 (en) *	2006-03-28	2010-04-13	Albany Molecular Research, Inc.	Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US7696166B2 (en) *	2006-03-28	2010-04-13	Albany Molecular Research, Inc.	Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
EP2337788B1 (de)	2008-10-17	2016-03-23	Wisconsin Alumni Research Foundation	Verfahren zur herstellung biologisch aktiver alpha-beta-peptide
WO2010052559A1 (en) *	2008-11-06	2010-05-14	Debio Recherche Pharmaceutique S.A.	Cycloundecadepsipeptide compounds and use of said compounds as a medicament
DE102008060549A1 (de)	2008-12-04	2010-06-10	MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V.	Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
WO2011141891A1 (en)	2010-05-12	2011-11-17	Debio Recherche Pharmaceutique S.A.	Use of cycloundecadepsipeptide compounds
PL2651965T3 (pl)	2010-12-15	2019-04-30	Contravir Pharmaceuticals Inc	Cząsteczki analogów cyklosporyny modyfikowane w aminokwasach 1 i 3
EP2705856A1 (de)	2012-09-07	2014-03-12	Deutsches Zentrum für Neurodegenerative Erkrankungen e.V.	Verbindungen zur Behandlung von neurodegenerativen Erkrankungen
GB201217560D0 (en) *	2012-10-02	2012-11-14	Mitopharm Ltd	Novel cyclic depsipeptide compounds and their uses
HUP1500502A2 (en)	2015-10-26	2017-04-28	Rotachrom Tech Kft	Process for the purification of cyclosporin-a

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2819094A1 (de) *	1977-05-10	1978-11-23	Sandoz Ag	Cyclosporin-derivate, ihre verwendung und herstellung
JPS5665853A (en) *	1979-11-01	1981-06-03	Sankyo Co Ltd	Mycoplanesin derivative and its preparation
EP0056782B1 (de) *	1981-01-09	1984-08-01	Sandoz Ag	Cyclosporine
US4649047A (en) *	1985-03-19	1987-03-10	University Of Georgia Research Foundation, Inc.	Ophthalmic treatment by topical administration of cyclosporin
IL84819A (en) *	1986-12-15	1993-07-08	Lilly Co Eli	Antibiotic a10255 complex and factors, process, microorganisms, and production therefor
GB8727807D0 (en) *	1987-11-27	1987-12-31	Lepetit Spa	Novel antibiotic compounds named a/16686 factors a'1,a'2 and a'3

1988
- 1988-06-15 DE DE3851268T patent/DE3851268T2/de not_active Expired - Lifetime
- 1988-06-15 ES ES88810408T patent/ES2056954T3/es not_active Expired - Lifetime
- 1988-06-15 AT AT88810408T patent/ATE110784T1/de not_active IP Right Cessation
- 1988-06-15 EP EP88810408A patent/EP0296123B1/de not_active Expired - Lifetime
- 1988-06-16 CA CA000569655A patent/CA1338183C/en not_active Expired - Lifetime
- 1988-06-17 FI FI882926A patent/FI87928C/fi active IP Right Grant
- 1988-06-17 HU HU883121A patent/HU204101B/hu unknown
- 1988-06-17 AU AU18124/88A patent/AU623078B2/en not_active Expired
- 1988-06-17 PH PH37083A patent/PH25933A/en unknown
- 1988-06-17 IL IL86789A patent/IL86789A/xx not_active IP Right Cessation
- 1988-06-17 PT PT87763A patent/PT87763B/pt not_active IP Right Cessation
- 1988-06-17 IE IE183888A patent/IE64008B1/en not_active IP Right Cessation
- 1988-06-17 MY MYPI88000673A patent/MY103735A/en unknown
- 1988-06-17 NZ NZ225071A patent/NZ225071A/xx unknown
- 1988-06-18 JP JP63151056A patent/JP2641256B2/ja not_active Expired - Lifetime
- 1988-06-18 KR KR1019880007371A patent/KR970010928B1/ko not_active IP Right Cessation
- 1988-06-20 US US07/209,680 patent/US5116816A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
MY103735A (en)	1993-09-30
FI882926A0 (fi)	1988-06-17
FI882926A (fi)	1988-12-20
NZ225071A (en)	1991-05-28
IL86789A (en)	1993-02-21
KR970010928B1 (ko)	1997-07-02
DE3851268D1 (de)	1994-10-06
AU623078B2 (en)	1992-05-07
EP0296123A3 (en)	1990-06-20
FI87928C (fi)	1993-03-10
FI87928B (fi)	1992-11-30
JPS6425798A (en)	1989-01-27
EP0296123A2 (de)	1988-12-21
US5116816A (en)	1992-05-26
IE64008B1 (en)	1995-06-28
CA1338183C (en)	1996-03-26
HUT50220A (en)	1989-12-28
ES2056954T3 (es)	1994-10-16
KR890000518A (ko)	1989-03-15
ATE110784T1 (de)	1994-09-15
PH25933A (en)	1991-12-19
IL86789A0 (en)	1988-11-30
AU1812488A (en)	1988-12-22
JP2641256B2 (ja)	1997-08-13
EP0296123B1 (de)	1994-08-31
IE881838L (en)	1988-12-19
PT87763B (pt)	1992-10-30
PT87763A (pt)	1988-07-01
HU204101B (en)	1991-11-28

Legal Events

Date	Code	Title	Description
1995-09-28	8364	No opposition during term of opposition
2000-06-21	8327	Change in the person/name/address of the patent owner	Owner name: NOVARTIS AG, BASEL, CH
2000-06-21	8328	Change in the person/name/address of the agent	Free format text: SPOTT WEINMILLER & PARTNER, 80336 MUENCHEN

Publication	Publication Date	Title
DE3851268T2 (de)	1995-01-26	Zyklische Peptolide.
AU588860B2 (en)	1989-09-28	Improvements in or relating to organic compounds
CA2154170A1 (en)	1994-08-04	Cyclic imide thione activated polyalkylene oxides
CA2194533A1 (en)	1997-07-13	Light-curing composite material
LU90842I2 (fr)	2001-11-26	Mabcampath-alemtuzumab et ses d-riv-s pharmaceutiquement acceptables
ES2110009T3 (es)	1998-02-01	Derivados de la estreptolisina o.
DK539285A (da)	1985-11-21	Immunosuppressiv faktor
CA2010739A1 (en)	1990-08-24	Bipolar voltage to frequency converter
ATE90731T1 (de)	1993-07-15	De-mannosylteicoplanin-derivate.
IT8921553A0 (it)	1989-08-25	Convertitore di segnali elettrici analogici sbilanciati in segnali tutto differenziali.
BE853720A (fr)	1977-10-18	Bouillon de culture indiquant la presence de levure candida et autres champignons
CA2143045A1 (en)	1995-08-25	Lactic-acid-containing cyclic depsipeptides having 18 ring atoms as endoparasiticidal agents, and process for their preparation
ES2099274T3 (es)	1997-05-16	Derivados de estreptolisina o.
NZ334073A (en)	2000-10-27	Process for producing cyclodepsipeptide compounds
FR2603302B1 (fr)	1989-10-27	Nouvelles souches de bacillus brevis et leur application
DK335288A (da)	1988-12-20	Peptolidderivater og fremgangsmaade til fremstilling deraf
Boulding	1987	Peace education as peace development
ES2066422T3 (es)	1995-03-01	Expresion de un arn multigenes con actividad de autoempalme.
TR200000683T2 (tr)	2000-12-21	Bir araç koltuğu mesnet çerçeve yapısı için körük.
ES2053601T3 (es)	1994-08-01	Agentes de biocontrol fundidos.
FR2405297A1 (fr)	1979-05-04	Nouveaux antibiotiques et leur preparation
MIREHINK et al.	1970	Satellite fungi of manganese-oxidizing bacteria
ES2028304T3 (es)	1992-07-01	Acelerometro ionicamente conductor.
SU586236A1 (ru)	1977-12-30	Сва
ES2018581B3 (es)	1991-04-16	Construccion de conexion de pared y de teja