DE3785571T2 - Klebeinrichtung zur anwendung an koerpergewebe. - Google Patents
Klebeinrichtung zur anwendung an koerpergewebe.Info
- Publication number
- DE3785571T2 DE3785571T2 DE8787119279T DE3785571T DE3785571T2 DE 3785571 T2 DE3785571 T2 DE 3785571T2 DE 8787119279 T DE8787119279 T DE 8787119279T DE 3785571 T DE3785571 T DE 3785571T DE 3785571 T2 DE3785571 T2 DE 3785571T2
- Authority
- DE
- Germany
- Prior art keywords
- adhesive
- adhesive device
- cellulose
- water
- adhesive layer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000001070 adhesive effect Effects 0.000 title claims description 54
- 239000000853 adhesive Substances 0.000 title claims description 52
- 239000012790 adhesive layer Substances 0.000 claims description 55
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 28
- 229920002125 Sokalan® Polymers 0.000 claims description 28
- 239000010410 layer Substances 0.000 claims description 28
- 239000001856 Ethyl cellulose Substances 0.000 claims description 19
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 19
- 229920001249 ethyl cellulose Polymers 0.000 claims description 19
- 229920002678 cellulose Polymers 0.000 claims description 18
- 239000001913 cellulose Substances 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 210000000214 mouth Anatomy 0.000 claims description 11
- 239000008177 pharmaceutical agent Substances 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 10
- 210000003296 saliva Anatomy 0.000 claims description 10
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 claims description 9
- 229920002301 cellulose acetate Polymers 0.000 claims description 8
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 claims description 8
- 239000000123 paper Substances 0.000 claims description 7
- 229920000642 polymer Polymers 0.000 claims description 7
- IVHBBMHQKZBJEU-UHFFFAOYSA-N cinchocaine hydrochloride Chemical group [Cl-].C1=CC=CC2=NC(OCCCC)=CC(C(=O)NCC[NH+](CC)CC)=C21 IVHBBMHQKZBJEU-UHFFFAOYSA-N 0.000 claims description 5
- 229940045574 dibucaine hydrochloride Drugs 0.000 claims description 5
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 4
- 229940030225 antihemorrhagics Drugs 0.000 claims description 4
- 210000001124 body fluid Anatomy 0.000 claims description 4
- 239000010839 body fluid Substances 0.000 claims description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 4
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 4
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 4
- 239000002874 hemostatic agent Substances 0.000 claims description 4
- 230000000202 analgesic effect Effects 0.000 claims description 3
- 230000000844 anti-bacterial effect Effects 0.000 claims description 3
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 3
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 3
- 239000002246 antineoplastic agent Substances 0.000 claims description 3
- 239000003899 bactericide agent Substances 0.000 claims description 3
- 229940127089 cytotoxic agent Drugs 0.000 claims description 3
- 239000000645 desinfectant Substances 0.000 claims description 3
- 239000003589 local anesthetic agent Substances 0.000 claims description 3
- 239000002294 steroidal antiinflammatory agent Substances 0.000 claims description 3
- 239000005526 vasoconstrictor agent Substances 0.000 claims description 3
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 2
- 229910052782 aluminium Inorganic materials 0.000 claims description 2
- 238000004132 cross linking Methods 0.000 claims description 2
- 239000004745 nonwoven fabric Substances 0.000 claims description 2
- 229920005989 resin Polymers 0.000 claims description 2
- 239000011347 resin Substances 0.000 claims description 2
- 239000004411 aluminium Substances 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 239000004744 fabric Substances 0.000 claims 1
- 229920003176 water-insoluble polymer Polymers 0.000 claims 1
- -1 carboxymethyl ethyl Chemical group 0.000 description 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 20
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 18
- 229940079593 drug Drugs 0.000 description 14
- 239000003814 drug Substances 0.000 description 14
- 239000004584 polyacrylic acid Substances 0.000 description 14
- 230000035807 sensation Effects 0.000 description 13
- 235000019615 sensations Nutrition 0.000 description 13
- 239000000523 sample Substances 0.000 description 11
- 235000011187 glycerol Nutrition 0.000 description 9
- 235000014113 dietary fatty acids Nutrition 0.000 description 8
- 239000000194 fatty acid Substances 0.000 description 8
- 229930195729 fatty acid Natural products 0.000 description 8
- 210000001519 tissue Anatomy 0.000 description 8
- 239000004359 castor oil Substances 0.000 description 7
- 235000019438 castor oil Nutrition 0.000 description 7
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
- 230000007774 longterm Effects 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- 239000003974 emollient agent Substances 0.000 description 4
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 3
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 3
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 3
- 210000002200 mouth mucosa Anatomy 0.000 description 3
- 239000000825 pharmaceutical preparation Substances 0.000 description 3
- 230000009993 protective function Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 210000000515 tooth Anatomy 0.000 description 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- JVTIXNMXDLQEJE-UHFFFAOYSA-N 2-decanoyloxypropyl decanoate 2-octanoyloxypropyl octanoate Chemical compound C(CCCCCCC)(=O)OCC(C)OC(CCCCCCC)=O.C(=O)(CCCCCCCCC)OCC(C)OC(=O)CCCCCCCCC JVTIXNMXDLQEJE-UHFFFAOYSA-N 0.000 description 2
- LVYLCBNXHHHPSB-UHFFFAOYSA-N 2-hydroxyethyl salicylate Chemical compound OCCOC(=O)C1=CC=CC=C1O LVYLCBNXHHHPSB-UHFFFAOYSA-N 0.000 description 2
- WLAMNBDJUVNPJU-UHFFFAOYSA-N 2-methylbutyric acid Chemical compound CCC(C)C(O)=O WLAMNBDJUVNPJU-UHFFFAOYSA-N 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
- 229920003114 HPC-L Polymers 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 229940125715 antihistaminic agent Drugs 0.000 description 2
- 239000000739 antihistaminic agent Substances 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 description 2
- XSXCZNVKFKNLPR-SDQBBNPISA-N carbazochrome Chemical compound NC(=O)N/N=C/1C(=O)C=C2N(C)CC(O)C2=C\1 XSXCZNVKFKNLPR-SDQBBNPISA-N 0.000 description 2
- 229960002631 carbazochrome Drugs 0.000 description 2
- 229960001747 cinchocaine Drugs 0.000 description 2
- PUFQVTATUTYEAL-UHFFFAOYSA-N cinchocaine Chemical compound C1=CC=CC2=NC(OCCCC)=CC(C(=O)NCCN(CC)CC)=C21 PUFQVTATUTYEAL-UHFFFAOYSA-N 0.000 description 2
- 229960000520 diphenhydramine Drugs 0.000 description 2
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 2
- 230000035622 drinking Effects 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 230000002439 hemostatic effect Effects 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 2
- 229960005015 local anesthetics Drugs 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 2
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 2
- 229960000401 tranexamic acid Drugs 0.000 description 2
- 229920003169 water-soluble polymer Polymers 0.000 description 2
- 239000001100 (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one Substances 0.000 description 1
- RDJGLLICXDHJDY-NSHDSACASA-N (2s)-2-(3-phenoxyphenyl)propanoic acid Chemical compound OC(=O)[C@@H](C)C1=CC=CC(OC=2C=CC=CC=2)=C1 RDJGLLICXDHJDY-NSHDSACASA-N 0.000 description 1
- SIACJRVYIPXFKS-UHFFFAOYSA-N (4-sulfamoylphenyl)methylazanium;chloride Chemical compound Cl.NCC1=CC=C(S(N)(=O)=O)C=C1 SIACJRVYIPXFKS-UHFFFAOYSA-N 0.000 description 1
- XIYOPDCBBDCGOE-IWVLMIASSA-N (4s,4ar,5s,5ar,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methylidene-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide Chemical compound C=C1C2=CC=CC(O)=C2C(O)=C2[C@@H]1[C@H](O)[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O XIYOPDCBBDCGOE-IWVLMIASSA-N 0.000 description 1
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 description 1
- CIVCELMLGDGMKZ-UHFFFAOYSA-N 2,4-dichloro-6-methylpyridine-3-carboxylic acid Chemical compound CC1=CC(Cl)=C(C(O)=O)C(Cl)=N1 CIVCELMLGDGMKZ-UHFFFAOYSA-N 0.000 description 1
- VZSRBBMJRBPUNF-UHFFFAOYSA-N 2-(2,3-dihydro-1H-inden-2-ylamino)-N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]pyrimidine-5-carboxamide Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C(=O)NCCC(N1CC2=C(CC1)NN=N2)=O VZSRBBMJRBPUNF-UHFFFAOYSA-N 0.000 description 1
- QVHDNNXTFDGCME-UHFFFAOYSA-N 2-(diethylamino)ethyl 4-amino-2-hydroxybenzoate;hydrochloride Chemical compound Cl.CCN(CC)CCOC(=O)C1=CC=C(N)C=C1O QVHDNNXTFDGCME-UHFFFAOYSA-N 0.000 description 1
- JIEKMACRVQTPRC-UHFFFAOYSA-N 2-[4-(4-chlorophenyl)-2-phenyl-5-thiazolyl]acetic acid Chemical compound OC(=O)CC=1SC(C=2C=CC=CC=2)=NC=1C1=CC=C(Cl)C=C1 JIEKMACRVQTPRC-UHFFFAOYSA-N 0.000 description 1
- XTIUAXFQEAMQRU-UHFFFAOYSA-N 2-[4-(butylamino)benzoyl]oxyethyl-diethylazanium;chloride Chemical compound [Cl-].CCCCNC1=CC=C(C(=O)OCC[NH+](CC)CC)C=C1 XTIUAXFQEAMQRU-UHFFFAOYSA-N 0.000 description 1
- WZFUQSJFWNHZHM-UHFFFAOYSA-N 2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperazin-1-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)N1CCN(CC1)CC(=O)N1CC2=C(CC1)NN=N2 WZFUQSJFWNHZHM-UHFFFAOYSA-N 0.000 description 1
- FSSICIQKZGUEAE-UHFFFAOYSA-N 2-[benzyl(pyridin-2-yl)amino]ethyl-dimethylazanium;chloride Chemical compound Cl.C=1C=CC=NC=1N(CCN(C)C)CC1=CC=CC=C1 FSSICIQKZGUEAE-UHFFFAOYSA-N 0.000 description 1
- ZXSGQNYQJIUMQN-UHFFFAOYSA-N 3-(2-methylpiperidin-1-ium-1-yl)propyl benzoate;chloride Chemical compound Cl.CC1CCCCN1CCCOC(=O)C1=CC=CC=C1 ZXSGQNYQJIUMQN-UHFFFAOYSA-N 0.000 description 1
- OBFSQMXGZIYMMN-UHFFFAOYSA-N 3-chloro-2-hexadecylpyridine Chemical compound CCCCCCCCCCCCCCCCC1=NC=CC=C1Cl OBFSQMXGZIYMMN-UHFFFAOYSA-N 0.000 description 1
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
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- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- DBAKFASWICGISY-BTJKTKAUSA-N Chlorpheniramine maleate Chemical compound OC(=O)\C=C/C(O)=O.C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 DBAKFASWICGISY-BTJKTKAUSA-N 0.000 description 1
- 239000004099 Chlortetracycline Substances 0.000 description 1
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- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 1
- OJMMVQQUTAEWLP-UHFFFAOYSA-N Lincomycin Natural products CN1CC(CCC)CC1C(=O)NC(C(C)O)C1C(O)C(O)C(O)C(SC)O1 OJMMVQQUTAEWLP-UHFFFAOYSA-N 0.000 description 1
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 description 1
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- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 description 1
- 239000004100 Oxytetracycline Substances 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
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- HCBIBCJNVBAKAB-UHFFFAOYSA-N Procaine hydrochloride Chemical compound Cl.CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 HCBIBCJNVBAKAB-UHFFFAOYSA-N 0.000 description 1
- 102000007327 Protamines Human genes 0.000 description 1
- 108010007568 Protamines Proteins 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 102000013265 Syntaxin 1 Human genes 0.000 description 1
- 108010090618 Syntaxin 1 Proteins 0.000 description 1
- PPWHTZKZQNXVAE-UHFFFAOYSA-N Tetracaine hydrochloride Chemical compound Cl.CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 PPWHTZKZQNXVAE-UHFFFAOYSA-N 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
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- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 229940124532 absorption promoter Drugs 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- ARHWPKZXBHOEEE-UHFFFAOYSA-N alclofenac Chemical compound OC(=O)CC1=CC=C(OCC=C)C(Cl)=C1 ARHWPKZXBHOEEE-UHFFFAOYSA-N 0.000 description 1
- 229960005142 alclofenac Drugs 0.000 description 1
- 125000005250 alkyl acrylate group Chemical class 0.000 description 1
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- 229960002117 triamcinolone acetonide Drugs 0.000 description 1
- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 1
- AISMNBXOJRHCIA-UHFFFAOYSA-N trimethylazanium;bromide Chemical compound Br.CN(C)C AISMNBXOJRHCIA-UHFFFAOYSA-N 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/58—Adhesives
- A61L15/585—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00655—Plasters adhesive
- A61F2013/0071—Plasters adhesive containing active agent
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Claims (17)
1. Klebeeinrichtung zur Anwendung an Körpergewebe,
bestehend aus: einer Klebeschicht mit einer am Körpergewebe
haftenden Oberfläche und
einer wasserunlöslichen oder in Wasser wenig löslichen
Rückschicht, die auf eine Oberfläche der Klebeschicht
abseitig von der klebenden Oberfläche aufgetragen ist,
wobei die Klebeschicht besteht aus einer Mischung aus
mindestens einem Acrylsäurepolymer, das unter
Klebewirkung in Wasser löslich oder quellbar ist, und einem
wasserunlöslichen Cellulosederivat.
2. Klebeeinrichtung gemäß Anspruch 1, wobei die Viskosität
des Acrylsäurepolymeren zwischen etwa 100 bis 200000
mPa.s(cp) in einer 10%igen w/w-Lösung in Wasser bei 25ºC
liegt.
3. Klebeeinrichtung gemäß Anspruch 1 oder 2, wobei das
wasserunlösliche Cellulosederivat umfaßt Ethylcellulose,
Carboxymethylcellulose, Celluloseacetat,
Celluloseacetophthalat oder Hydroxypropyl-methylcellulosephthalat.
4. Klebeeinrichtung gemäß einem jeden der vorangehenden
Ansprüche, wobei das Gewichtsverhältnis des
Acrylsäure-Polymeren zu dem wasserunlöslichen Cellulosederivat
zwischen etwa 99 : 1 und etwa 50 : 50 liegt.
5. Klebeeinrichtung gemäß einem jeden der vorangehenden An-
TEXTE FEHLT
Papier, Gewebe, Vliesgewebe oder einer Aluminiumschicht
besteht.
6. Klebeeinrichtung gemäß einem jeden der vorangehenden
Ansprüche 1 bis 4, wobei die Rückschicht ein Polymer ist
bestehend aus Ethylcellulose, Celluloseacetat,
Celluloseacetophthalat, Hydroxypropylmethyl-cellulosephthalat,
Venylacetatharz oder einem pharmakologisch annehmbaren
wasserunlöslichen Polymeren, das durch Vernetzung
unlöslich gemacht ist.
7. Klebeeinrichtung gemäß einem jeden der vorangehenden
Ansprüche, wobei die Dicke der Klebeschicht zwischen etwa
10 bis etwa 1000 um und die Dicke der Rückschicht
zwischen etwa 1 bis 100 um liegen.
8. Klebeeinrichtung gemäß Anspruch 7, wobei die Dicke der
Klebeschicht zwischen etwa 20 und 200 um und die Dicke
der Rückschicht zwischen etwa 5 bis 30 um liegen.
9. Klebeeinrichtung gemäß einem jeden der vorangehenden
Ansprüche, wobei die Klebeschicht weiterhin ein
pharmazeutisches Mittel enthält.
10. Klebeeinrichtung gemäß Anspruch 9, wobei das
pharmazeutische Mittel ein analgetisch entzündungshemmendes
Mittel, ein steroidales entzündungshemmendes Mittel, ein
Lokalanästhetikum, ein Bakterizid, ein
Desinfektionsmittel, ein gefäßverengendes Mittel, ein Hämostatikum, ein
Chemotherapeutikum oder Antibiotikum ist und das
pharmazeutische Mittel in der Klebeschicht in einer Menge
zwischen etwa 0,001 bis etwa 20 Gew.-% vorliegt.
11. Klebeeinrichtung gemäß Anspruch 10, wobei das
pharmazeutische Mittel Methyl-p-oxybenzoesäure ist.
12. Klebeeinrichtung gemäß Anspruch 10, wobei das
pharmazeutische Mittel Dibucainhydrochlorid ist.
13. Klebeeinrichtung gemäß Anspruch 10, wobei das
pharmazeutische Mittel Tranexisäure ist.
14. Chirurgische Packung, enthaltend eine Klebeeinrichtung
gemäß Anspruch 1.
15. Klebeeinrichtung mit einem pharmazeutischen Mittel gemäß
Anspruch 10 bis 13, vorgesehen zur Anwendung an
Körpergewebe, wobei durch die Berührung mit Körperflüssigkeit
das pharmazeutische Mittel progressiv an das
Körpergewebe und/oder die Körperflüssigkeit abgegeben wird.
16. Klebeeinrichtung gemäß Anspruch 15, vorgesehen zur
Anwendung in einer oralen Kavität, wobei durch die
Berührung mit Speichel das pharmazeutische Mittel progressiv
an das Körpergewebe und/oder den Speichel abgegeben
wird.
17. Klebeeinrichtung gemäß Anspruch 16, vorgesehen für die
Anwendung an gingivales Gewebe, Lippen-Gewebe oder
Zähne, wobei durch die Berührung mit Speichel das
pharmazeutische Mittel progressiv an das gingivale Gewebe,
das Lippen-Gewebe oder die Zähne und/oder den Speichel
abgegeben wird.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP61310993A JPH0744940B2 (ja) | 1986-12-24 | 1986-12-24 | 口腔貼付用基材 |
CA000557368A CA1327314C (en) | 1986-12-24 | 1988-01-26 | Adhesive device for application to body tissue |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3785571D1 DE3785571D1 (de) | 1993-05-27 |
DE3785571T2 true DE3785571T2 (de) | 1993-08-12 |
Family
ID=25671681
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8787119279T Expired - Lifetime DE3785571T2 (de) | 1986-12-24 | 1987-12-28 | Klebeinrichtung zur anwendung an koerpergewebe. |
Country Status (5)
Country | Link |
---|---|
US (1) | US4900554A (de) |
EP (1) | EP0275550B1 (de) |
JP (1) | JPH0744940B2 (de) |
CA (1) | CA1327314C (de) |
DE (1) | DE3785571T2 (de) |
Families Citing this family (148)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE65163B1 (en) * | 1987-06-29 | 1995-10-04 | Squibb & Sons Inc | Process for preparing a wound dressing comprising a hydrophilic acrylic adhesive layer |
US4983395A (en) * | 1987-11-12 | 1991-01-08 | Theratech Inc. | Device for administering an active agent to the skin or mucosa |
US5234957A (en) * | 1991-02-27 | 1993-08-10 | Noven Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
US5446070A (en) * | 1991-02-27 | 1995-08-29 | Nover Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
AU620439B2 (en) * | 1988-09-12 | 1992-02-20 | Johnson & Johnson Patient Care, Inc. | Antibacterial adhesive composition |
US5032384A (en) * | 1989-01-27 | 1991-07-16 | Block Drug Company, Inc. | Compositions and method for the treatment of disease |
JP2656338B2 (ja) * | 1989-01-31 | 1997-09-24 | 日東電工株式会社 | 口腔粘膜貼付製剤 |
JPH0645536B2 (ja) * | 1989-01-31 | 1994-06-15 | 日東電工株式会社 | 口腔粘膜貼付剤および口腔粘膜貼付製剤 |
JP2697884B2 (ja) * | 1989-02-08 | 1998-01-14 | 積水化学工業株式会社 | 口腔内貼付用バンデージ |
CA2018471A1 (en) * | 1989-07-28 | 1991-01-28 | Ian W. Kellaway | Mucoadhesive hydrogels delivery system |
US6017521A (en) * | 1989-10-31 | 2000-01-25 | Columbia Laboratories, Inc. | Use of polycarboxylic acid polymers to treat vaginal infections |
MC2204A1 (fr) * | 1989-10-31 | 1992-11-26 | Columbia Lab Inc | Composition et methode d'humidification de tissus |
US5084267A (en) * | 1989-11-17 | 1992-01-28 | The Procter & Gamble Company | Sustained release compositions for treating periodontal disease |
US5173299A (en) * | 1989-11-17 | 1992-12-22 | The Procter & Gamble Company | Sustained release compositions for treating periodontal disease |
CA2073254A1 (en) * | 1990-11-09 | 1992-05-10 | Mitsuji Akazawa | Procaterol-containing preparation for application to the skin |
US5332576A (en) * | 1991-02-27 | 1994-07-26 | Noven Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
US5264219A (en) * | 1992-08-07 | 1993-11-23 | Minnesota Mining And Manufacturing Company | Transdermal drug delivery backing |
GB2273044B (en) * | 1992-12-02 | 1997-04-09 | Pacific Chem Co Ltd | Medicinal patches for percutaneous administration |
EP0676962B9 (de) * | 1992-12-31 | 2002-04-03 | Sunkyong Industries Co., Ltd. | Pharmazeutische zusammensetzungen mit verbesserter perkutaner absorption für piroxicam |
US5447725A (en) * | 1993-06-11 | 1995-09-05 | The Procter & Gamble Company | Methods for aiding periodontal tissue regeneration |
US5578315A (en) * | 1993-12-01 | 1996-11-26 | Rutgers, The State University Of New Jersey | Mucosal adhesive device for long-acting delivery of pharmaceutical combinations in oral cavity |
DE4341572C1 (de) * | 1993-12-07 | 1995-06-22 | Univ Dresden Tech | Zahnriemengetriebe |
US5762955A (en) | 1994-02-04 | 1998-06-09 | Smith; Stephen Jay | Method for application and maintenance of medication on body tissue |
DE69625549T2 (de) * | 1995-06-27 | 2003-05-15 | Kao Corp | Pflaster mit wasserlöslicher Klebeschicht |
US5955097A (en) * | 1996-10-18 | 1999-09-21 | Virotex Corporation | Pharmaceutical preparation applicable to mucosal surfaces and body tissues |
US5800832A (en) * | 1996-10-18 | 1998-09-01 | Virotex Corporation | Bioerodable film for delivery of pharmaceutical compounds to mucosal surfaces |
DE19652188C2 (de) * | 1996-12-16 | 2002-02-14 | Lohmann Therapie Syst Lts | Flache Arzneizubereitung zur Applikation und Freisetzung von Buprenorphin oder einer pharmakologisch vergleichbaren Substanz in der Mundhöhle und Verfahren zu ihrer Herstellung |
KR100215027B1 (ko) * | 1997-01-27 | 1999-08-16 | 성재갑 | 스테로이드계 약물의 경피흡수투여용 조성물 및 이를 포함하는 경피흡수투여용 제형 |
EP0858805A3 (de) * | 1997-02-13 | 1998-09-02 | National Research Institute of Chinese Medicine | Transdermale Oxicamzubereitungen |
US20020018754A1 (en) * | 1999-03-15 | 2002-02-14 | Paul Albert Sagel | Shapes for tooth whitening strips |
US6582708B1 (en) | 2000-06-28 | 2003-06-24 | The Procter & Gamble Company | Tooth whitening substance |
US6136297A (en) * | 1997-06-06 | 2000-10-24 | The Procter & Gamble Company | Delivery system for an oral care substance using a strip of material having low flexural stiffness |
US5894017A (en) * | 1997-06-06 | 1999-04-13 | The Procter & Gamble Company | Delivery system for an oral care substance using a strip of material having low flexural stiffness |
US5879691A (en) * | 1997-06-06 | 1999-03-09 | The Procter & Gamble Company | Delivery system for a tooth whitener using a strip of material having low flexural stiffness |
US6096328A (en) * | 1997-06-06 | 2000-08-01 | The Procter & Gamble Company | Delivery system for an oral care substance using a strip of material having low flexural stiffness |
US5901706A (en) * | 1997-06-09 | 1999-05-11 | Kimberly-Clark Worldwide, Inc. | Absorbent surgical drape |
US6197331B1 (en) | 1997-07-24 | 2001-03-06 | Perio Products Ltd. | Pharmaceutical oral patch for controlled release of pharmaceutical agents in the oral cavity |
US6638603B1 (en) | 1997-08-15 | 2003-10-28 | Kimberly-Clark Worldwide, Inc. | Screen printed coating on water-sensitive film for water protection |
US20050048102A1 (en) * | 1997-10-16 | 2005-03-03 | Virotex Corporation | Pharmaceutical carrier device suitable for delivery of pharmaceutical compounds to mucosal surfaces |
US5981012A (en) | 1997-11-25 | 1999-11-09 | Kimberly-Clark Worldwide, Inc. | Flushable release liner comprising a release coating on a water-sensitive film |
US5985396A (en) * | 1997-11-25 | 1999-11-16 | Kimberly-Clark Worldwide, Inc. | Flushable release liners and methods of making the same |
US6530910B1 (en) | 1997-12-31 | 2003-03-11 | Kimberly-Clark Worldwide, Inc. | Flushable release film with combination wiper |
US6103266A (en) * | 1998-04-22 | 2000-08-15 | Tapolsky; Gilles H. | Pharmaceutical gel preparation applicable to mucosal surfaces and body tissues |
US20050147690A1 (en) * | 1998-09-25 | 2005-07-07 | Masters David B. | Biocompatible protein particles, particle devices and methods thereof |
US7662409B2 (en) * | 1998-09-25 | 2010-02-16 | Gel-Del Technologies, Inc. | Protein matrix materials, devices and methods of making and using thereof |
WO2000027327A1 (en) * | 1998-11-12 | 2000-05-18 | Polymer Biosciences, Inc. | Hemostatic polymer useful for rapid blood coagulation and hemostasis |
DE19905801B4 (de) * | 1999-02-12 | 2008-03-13 | Lts Lohmann Therapie-Systeme Ag | Verfahren zur Herstellung folienförmiger Darreichungsformen |
US6800329B2 (en) * | 1999-02-12 | 2004-10-05 | Lts Lohmann Therapie-Systeme Ag | Method for producing film-type dosage |
US6319510B1 (en) | 1999-04-20 | 2001-11-20 | Alayne Yates | Gum pad for delivery of medication to mucosal tissues |
WO2000074661A2 (en) * | 1999-06-05 | 2000-12-14 | Noven Pharmaceuticals, Inc. | Solubility enhancement of drugs in transdermal drug delivery systems and methods of use |
MXPA02000262A (es) | 1999-07-02 | 2005-08-16 | Procter & Gamble | Sistema de administracion para composiciones de cuidado oral que comprenden resinas de organosiloxano utilizando una tira de refuerzo removible. |
US6463335B1 (en) | 1999-10-04 | 2002-10-08 | Medtronic, Inc. | Temporary medical electrical lead having electrode mounting pad with biodegradable adhesive |
AR026073A1 (es) | 1999-10-20 | 2002-12-26 | Nycomed Gmbh | Composicion farmaceutica acuosa que contiene ciclesonida |
US6905672B2 (en) * | 1999-12-08 | 2005-06-14 | The Procter & Gamble Company | Compositions and methods to inhibit tartar and microbes using denture adhesive compositions with colorants |
US6432415B1 (en) | 1999-12-17 | 2002-08-13 | Axrix Laboratories, Inc. | Pharmaceutical gel and aerosol formulations and methods to administer the same to skin and mucosal surfaces |
US20020004065A1 (en) | 2000-01-20 | 2002-01-10 | David Kanios | Compositions and methods to effect the release profile in the transdermal administration of active agents |
US6682721B2 (en) * | 2000-03-17 | 2004-01-27 | Lg Household & Healthcare Ltd. | Patches for teeth whitening |
US8652446B2 (en) * | 2000-03-17 | 2014-02-18 | Lg Household & Healthcare Ltd. | Apparatus and method for whitening teeth |
US6689344B2 (en) | 2000-03-17 | 2004-02-10 | Lg Household & Healthcare Ltd. | Patches for teeth whitening |
US7785572B2 (en) * | 2000-03-17 | 2010-08-31 | Lg Household And Health Care Ltd. | Method and device for teeth whitening using a dry type adhesive |
JP4683168B2 (ja) * | 2000-05-17 | 2011-05-11 | ライオン株式会社 | 歯牙又は歯茎用貼付剤 |
CA2411055C (en) * | 2000-06-28 | 2015-07-14 | The Procter & Gamble Company | Structures and compositions increasing the stability of peroxide actives |
US7803392B2 (en) * | 2000-12-27 | 2010-09-28 | University Of Kentucky Research Foundation | pH-Sensitive mucoadhesive film-forming gels and wax-film composites suitable for topical and mucosal delivery of molecules |
US6514484B2 (en) | 2001-03-19 | 2003-02-04 | The Procter & Gamble Company | Systems for delivering a cosmetic and/or therapeutic active to oral surfaces using an integral carrier |
US6946142B2 (en) * | 2001-06-23 | 2005-09-20 | Lg Household & Healthcare Ltd. | Multi-layer patches for teeth whitening |
US6585997B2 (en) | 2001-08-16 | 2003-07-01 | Access Pharmaceuticals, Inc. | Mucoadhesive erodible drug delivery device for controlled administration of pharmaceuticals and other active compounds |
US20060073174A1 (en) * | 2001-08-16 | 2006-04-06 | Access Pharmaceuticals, Inc. | Adherent and erodible film to treat a moist surface of a body tissue |
DE60226249T2 (de) * | 2001-08-17 | 2009-05-14 | Smithkline Beecham P.L.C., Brentford | Streifen zur abgabe eines mundpflegewirkstoffes |
CA2460842A1 (en) * | 2001-09-20 | 2003-03-27 | Telemessenger Limited | An information transmission system |
US7666337B2 (en) * | 2002-04-11 | 2010-02-23 | Monosol Rx, Llc | Polyethylene oxide-based films and drug delivery systems made therefrom |
US8765167B2 (en) * | 2001-10-12 | 2014-07-01 | Monosol Rx, Llc | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
US8900497B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for making a film having a substantially uniform distribution of components |
US10285910B2 (en) | 2001-10-12 | 2019-05-14 | Aquestive Therapeutics, Inc. | Sublingual and buccal film compositions |
US20100021526A1 (en) * | 2001-10-12 | 2010-01-28 | Monosol Rx, Llc | Ph modulated films for delivery of actives |
US7425292B2 (en) * | 2001-10-12 | 2008-09-16 | Monosol Rx, Llc | Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom |
US11207805B2 (en) | 2001-10-12 | 2021-12-28 | Aquestive Therapeutics, Inc. | Process for manufacturing a resulting pharmaceutical film |
US20190328679A1 (en) | 2001-10-12 | 2019-10-31 | Aquestive Therapeutics, Inc. | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
US8663687B2 (en) | 2001-10-12 | 2014-03-04 | Monosol Rx, Llc | Film compositions for delivery of actives |
US20110033542A1 (en) | 2009-08-07 | 2011-02-10 | Monosol Rx, Llc | Sublingual and buccal film compositions |
US20060039958A1 (en) * | 2003-05-28 | 2006-02-23 | Monosolrx, Llc. | Multi-layer films having uniform content |
US20070154527A1 (en) * | 2001-10-12 | 2007-07-05 | Monosoirx, Llc | Topical film compositions for delivery of actives |
US8603514B2 (en) | 2002-04-11 | 2013-12-10 | Monosol Rx, Llc | Uniform films for rapid dissolve dosage form incorporating taste-masking compositions |
US8900498B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for manufacturing a resulting multi-layer pharmaceutical film |
US7910641B2 (en) * | 2001-10-12 | 2011-03-22 | Monosol Rx, Llc | PH modulated films for delivery of actives |
US20070281003A1 (en) | 2001-10-12 | 2007-12-06 | Fuisz Richard C | Polymer-Based Films and Drug Delivery Systems Made Therefrom |
US7357891B2 (en) * | 2001-10-12 | 2008-04-15 | Monosol Rx, Llc | Process for making an ingestible film |
US8017150B2 (en) * | 2002-04-11 | 2011-09-13 | Monosol Rx, Llc | Polyethylene oxide-based films and drug delivery systems made therefrom |
AU2003225212A1 (en) * | 2002-04-29 | 2003-11-17 | Gel-Del Technologies, Inc. | Biomatrix structural containment and fixation systems and methods of use thereof |
US6949240B2 (en) * | 2002-05-23 | 2005-09-27 | The Procter & Gamble Company | Tooth whitening products |
CA2505796C (en) * | 2002-07-22 | 2012-01-03 | Monosolrx Llc | Packaging and dispensing of rapid dissolve dosage form |
US8524200B2 (en) | 2002-09-11 | 2013-09-03 | The Procter & Gamble Company | Tooth whitening products |
US20050019277A1 (en) * | 2002-09-11 | 2005-01-27 | The Procter & Gamble Company | Tooth whitening products |
US20040120903A1 (en) * | 2002-09-11 | 2004-06-24 | The Procter & Gamble Company | Tooth whitening strips |
US20050100515A1 (en) * | 2002-09-11 | 2005-05-12 | The Procter & Gamble Company | Tooth whitening products |
DE10252726B4 (de) | 2002-11-13 | 2008-05-08 | Lts Lohmann Therapie-Systeme Ag | Mehrschichtiges transmucosales therapeutisches System |
US7306812B2 (en) * | 2003-05-09 | 2007-12-11 | Cephalon, Inc. | Dissolvable backing layer for use with a transmucosal delivery device |
US7276246B2 (en) * | 2003-05-09 | 2007-10-02 | Cephalon, Inc. | Dissolvable backing layer for use with a transmucosal delivery device |
US8465537B2 (en) * | 2003-06-17 | 2013-06-18 | Gel-Del Technologies, Inc. | Encapsulated or coated stent systems |
US8153591B2 (en) * | 2003-08-26 | 2012-04-10 | Gel-Del Technologies, Inc. | Protein biomaterials and biocoacervates and methods of making and using thereof |
WO2005055945A2 (en) * | 2003-12-08 | 2005-06-23 | Gel-Del Technologies, Inc. | Mucoadhesive drug delivery devices and methods of making and using thereof |
JP4128521B2 (ja) * | 2003-12-19 | 2008-07-30 | 信越化学工業株式会社 | ゲル状シート及びその製造方法 |
US20070098769A1 (en) * | 2004-04-16 | 2007-05-03 | Champion Mary J | Systems and methods for treating hot flashes associated with menopause |
EP1591106B1 (de) * | 2004-04-28 | 2009-07-22 | Shin-Etsu Chemical Co., Ltd. | Filmzubereitung und Verfahren zu deren Herstelllung |
US20060018845A1 (en) * | 2004-07-23 | 2006-01-26 | Edelstein Janette S | Tooth whitening |
EP2767163A1 (de) | 2005-02-17 | 2014-08-20 | Abbott Laboratories | Transmukosale Verabreichung von Arzneimittelzusammensetzungen zur Behandlung und Vorbeugung von Erkrankungen bei Tieren |
US20100323323A1 (en) * | 2005-06-24 | 2010-12-23 | Cao Group, Inc. | Pliable gingival isolation material |
JP2009523808A (ja) * | 2006-01-20 | 2009-06-25 | モノソル アールエックス リミテッド ライアビリティ カンパニー | 活性物質の粘膜投与のためのフィルム包帯 |
CA2636026A1 (en) * | 2006-01-20 | 2007-07-26 | Monosol Rx, Llc | Film lined pouch and method of manufacturing this pouch |
US20070192438A1 (en) * | 2006-02-10 | 2007-08-16 | Esmond Goei | System and method for on-demand delivery of media products |
US20070192182A1 (en) * | 2006-02-10 | 2007-08-16 | Tovin Monaco | Method of delivering coupons using customer data |
US20070192183A1 (en) * | 2006-02-10 | 2007-08-16 | Tovin Monaco | System and architecture for providing retail buying options to consumer using customer data |
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US20070248653A1 (en) * | 2006-04-20 | 2007-10-25 | Cochrum Kent C | Hemostatic compositions and methods for controlling bleeding |
ES2577390T3 (es) | 2006-07-21 | 2016-07-14 | Biodelivery Sciences International, Inc. | Dispositivos de administración transmucosa con mayor captación |
JP4739452B2 (ja) * | 2006-09-20 | 2011-08-03 | モノソル アールエックス リミテッド ライアビリティ カンパニー | 発泡を減じる風味付与剤を含む喫食可能な水溶性フィルム |
EP2077824A4 (de) * | 2006-09-29 | 2012-07-18 | Monosol Rx Llc | In folie eingebettete verpackung und herstellungsverfahren dafür |
US8299316B2 (en) * | 2007-12-18 | 2012-10-30 | Ethicon, Inc. | Hemostatic device |
US8629314B2 (en) * | 2007-12-18 | 2014-01-14 | Ethicon, Inc. | Surgical barriers having adhesion inhibiting properties |
CA2711001A1 (en) * | 2007-12-26 | 2009-07-09 | Gel-Del Technologies, Inc. | Biocompatible protein-based particles and methods thereof |
WO2009150596A1 (en) * | 2008-06-09 | 2009-12-17 | Densys Ltd | Intra-oral surface non-aqueous hydrophobic coating composition and method |
WO2010057177A2 (en) | 2008-11-17 | 2010-05-20 | Gel-Del Technologies, Inc. | Protein biomaterial and biocoacervate vessel graft systems and methods of making and using thereof |
US8475832B2 (en) * | 2009-08-07 | 2013-07-02 | Rb Pharmaceuticals Limited | Sublingual and buccal film compositions |
US9549842B2 (en) | 2011-02-04 | 2017-01-24 | Joseph E. Kovarik | Buccal bioadhesive strip and method of treating snoring and sleep apnea |
US8701671B2 (en) | 2011-02-04 | 2014-04-22 | Joseph E. Kovarik | Non-surgical method and system for reducing snoring |
EP2504019A2 (de) | 2009-11-25 | 2012-10-03 | ArisGen SA | Zusammensetzung zur verabreichung über die schleimhaut mit einem komplex aus einem peptid und einer kronenverbindung und/oder einem gegenion |
US9572773B2 (en) | 2010-04-26 | 2017-02-21 | Novartis A.G. | Layered drug delivery device |
EP2579844B1 (de) | 2010-06-10 | 2016-02-24 | Midatech Ltd. | Systeme zur freisetzung von nanopartikeln |
US9149959B2 (en) | 2010-10-22 | 2015-10-06 | Monosol Rx, Llc | Manufacturing of small film strips |
US11951140B2 (en) | 2011-02-04 | 2024-04-09 | Seed Health, Inc. | Modulation of an individual's gut microbiome to address osteoporosis and bone disease |
US11844720B2 (en) | 2011-02-04 | 2023-12-19 | Seed Health, Inc. | Method and system to reduce the likelihood of dental caries and halitosis |
US11951139B2 (en) | 2015-11-30 | 2024-04-09 | Seed Health, Inc. | Method and system for reducing the likelihood of osteoporosis |
US11998479B2 (en) | 2011-02-04 | 2024-06-04 | Seed Health, Inc. | Method and system for addressing adverse effects on the oral microbiome and restoring gingival health caused by sodium lauryl sulphate exposure |
CA2845634C (en) | 2011-08-18 | 2021-07-13 | Biodelivery Sciences International, Inc. | Abuse-resistant mucoadhesive devices for delivery of buprenorphine |
US9901539B2 (en) | 2011-12-21 | 2018-02-27 | Biodelivery Sciences International, Inc. | Transmucosal drug delivery devices for use in chronic pain relief |
BR112015008666B1 (pt) | 2012-10-17 | 2020-04-07 | Procter & Gamble | produto extensível para tratamento dental e método de aplicação de um ativo para tratamento bucal |
WO2014070485A1 (en) * | 2012-10-22 | 2014-05-08 | 2010 Mfi, Llc | Dissolvable strip for treatment of oral thermal burns |
US12005085B2 (en) | 2013-12-20 | 2024-06-11 | Seed Health, Inc. | Probiotic method and composition for maintaining a healthy vaginal microbiome |
US11998574B2 (en) | 2013-12-20 | 2024-06-04 | Seed Health, Inc. | Method and system for modulating an individual's skin microbiome |
US11969445B2 (en) | 2013-12-20 | 2024-04-30 | Seed Health, Inc. | Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH |
US11826388B2 (en) | 2013-12-20 | 2023-11-28 | Seed Health, Inc. | Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation |
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US11833177B2 (en) | 2013-12-20 | 2023-12-05 | Seed Health, Inc. | Probiotic to enhance an individual's skin microbiome |
US11980643B2 (en) | 2013-12-20 | 2024-05-14 | Seed Health, Inc. | Method and system to modify an individual's gut-brain axis to provide neurocognitive protection |
EP2889030A1 (de) | 2013-12-30 | 2015-07-01 | Uluru Inc. | Steuerung der Erosionsraten von mukoadhäsiven Vorrichtungen mit Lieferung von Wirkstoffen und anderen Verbindungen und Bereitstellung erhöhter und unterschiedlicher therapeutischer Blutwerte |
CN109310646A (zh) | 2016-05-05 | 2019-02-05 | 阿奎斯蒂弗医疗股份有限公司 | 增强递送的肾上腺素组合物 |
US11273131B2 (en) | 2016-05-05 | 2022-03-15 | Aquestive Therapeutics, Inc. | Pharmaceutical compositions with enhanced permeation |
JPWO2021015241A1 (de) * | 2019-07-22 | 2021-01-28 | ||
US10758329B1 (en) | 2019-08-20 | 2020-09-01 | Raymond L. Wright, III | Hydrating mouth guard |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU553343B2 (en) * | 1981-08-10 | 1986-07-10 | Advance Electrode Kabushikikaisya | Absorbent adhesive bandage with medicament release |
EP0186019B1 (de) * | 1984-12-22 | 1993-10-06 | Schwarz Pharma Ag | Wirkstoffpflaster |
JPS61280426A (ja) * | 1985-06-04 | 1986-12-11 | Ikeda Mohandou:Kk | 消炎鎮痛用貼付剤 |
DE3677983D1 (de) * | 1986-09-05 | 1991-04-11 | Braun Karl Otto Kg | Verwendung einer klebemasse fuer einen kohaesiven verbandstoff. |
-
1986
- 1986-12-24 JP JP61310993A patent/JPH0744940B2/ja not_active Expired - Lifetime
-
1987
- 1987-12-23 US US07/137,034 patent/US4900554A/en not_active Expired - Lifetime
- 1987-12-28 DE DE8787119279T patent/DE3785571T2/de not_active Expired - Lifetime
- 1987-12-28 EP EP87119279A patent/EP0275550B1/de not_active Expired - Lifetime
-
1988
- 1988-01-26 CA CA000557368A patent/CA1327314C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US4900554A (en) | 1990-02-13 |
EP0275550A1 (de) | 1988-07-27 |
CA1327314C (en) | 1994-03-01 |
JPS63160649A (ja) | 1988-07-04 |
JPH0744940B2 (ja) | 1995-05-17 |
DE3785571D1 (de) | 1993-05-27 |
EP0275550B1 (de) | 1993-04-21 |
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