DE3782785T2 - Piperidinderivate, ihre herstellung und ihre verwendung. - Google Patents

Piperidinderivate, ihre herstellung und ihre verwendung.

Info

Publication number
DE3782785T2
DE3782785T2 DE8787111470T DE3782785T DE3782785T2 DE 3782785 T2 DE3782785 T2 DE 3782785T2 DE 8787111470 T DE8787111470 T DE 8787111470T DE 3782785 T DE3782785 T DE 3782785T DE 3782785 T2 DE3782785 T2 DE 3782785T2
Authority
DE
Germany
Prior art keywords
chem
alkyl
production
independently
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8787111470T
Other languages
English (en)
Other versions
DE3782785D1 (de
Inventor
Leif Helth Jensen
Per Sauerberg
Frank Waetjen
Jens William Kindtler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK426986A external-priority patent/DK426986D0/da
Priority claimed from DK597186A external-priority patent/DK597186D0/da
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Application granted granted Critical
Publication of DE3782785D1 publication Critical patent/DE3782785D1/de
Publication of DE3782785T2 publication Critical patent/DE3782785T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE8787111470T 1986-09-08 1987-08-07 Piperidinderivate, ihre herstellung und ihre verwendung. Expired - Fee Related DE3782785T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK426986A DK426986D0 (da) 1986-09-08 1986-09-08 Piperidine forbindelser, deres fremstilling og anvendelse
DK597186A DK597186D0 (da) 1986-12-12 1986-12-12 Heterocykliske forbindelser, deres fremstilling og anvendelse

Publications (2)

Publication Number Publication Date
DE3782785D1 DE3782785D1 (de) 1993-01-07
DE3782785T2 true DE3782785T2 (de) 1993-04-01

Family

ID=26067417

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787111470T Expired - Fee Related DE3782785T2 (de) 1986-09-08 1987-08-07 Piperidinderivate, ihre herstellung und ihre verwendung.

Country Status (17)

Country Link
US (2) US4837241A (de)
EP (1) EP0259621B1 (de)
JP (1) JPH0662616B2 (de)
KR (1) KR950009366B1 (de)
AT (1) ATE82751T1 (de)
AU (1) AU603603B2 (de)
CA (1) CA1340937C (de)
DE (1) DE3782785T2 (de)
ES (1) ES2043624T3 (de)
FI (1) FI86424C (de)
GR (1) GR3007053T3 (de)
IE (1) IE62485B1 (de)
IL (1) IL83275A (de)
NO (1) NO169285C (de)
NZ (1) NZ221672A (de)
PH (1) PH23584A (de)
PT (1) PT85650B (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ219646A (en) * 1986-03-27 1990-10-26 Merck Sharp & Dohme Oxadiazole derivatives of azacyclics for treating cns disorders
GB8714789D0 (en) * 1987-06-24 1987-07-29 Lundbeck & Co As H Heterocyclic compounds
IL88156A (en) * 1987-11-13 1997-02-18 Novo Nordisk As Azacyclic compounds their preparation and pharmaceutical compositions containing them
EP0322034A3 (de) * 1987-12-22 1991-01-02 Merck Sharp & Dohme Ltd. Methyltetrahydropyridyloxadiazole
IL88846A0 (en) * 1988-01-08 1989-07-31 Merck Sharp & Dohme Lipophilic oxadiazoles,their preparation and pharmaceutical compositions containing them
DK162892C (da) * 1988-07-04 1992-05-11 Novo Nordisk As 1,2,5,6-tetrahydropyridinforbindelser, deres fremstilling og farmaceutiske praeparater indeholdende disse
US5260311A (en) * 1989-02-22 1993-11-09 Novo Nordisk A/S Piperidine compounds and their use
US5264444A (en) * 1989-02-22 1993-11-23 Novo Nordisk A/S Piperidine compounds and use
US5328925A (en) * 1989-02-22 1994-07-12 Novo Nordisk A/S Piperidine compounds and their use
US5043345A (en) * 1989-02-22 1991-08-27 Novo Nordisk A/S Piperidine compounds and their preparation and use
EP0459568A3 (en) * 1990-05-31 1992-09-30 Merck Sharp & Dohme Ltd. Substituted oxadiazoles and thiadiazoles for use in the treatment of glaucoma and novel compounds having such use
IE912760A1 (en) * 1990-08-06 1992-02-12 Smith Kline French Lab Compounds
DK198490D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
EP0561913B1 (de) * 1990-11-29 1998-04-01 Allergan, Inc. Verwendung von pyridine derivate zur behandlung der okulären hypertomie
US5175166A (en) * 1991-08-27 1992-12-29 The University Of Toledo Muscarinic agonists
AU3171493A (en) * 1991-12-31 1993-07-28 Fujisawa Pharmaceutical Co., Ltd. Oxadiazole derivatives having acetylcholinesterase-inhibitory and muscarinic agonist activity
US5424301A (en) * 1993-02-01 1995-06-13 Warner-Lambert Company Starch stabilized o-substituted tetrahydropyridine oxime cholinergic agents
ATE180780T1 (de) * 1993-08-05 1999-06-15 Hoechst Marion Roussel Inc 2-(piperidin-4-yl, pyridin-4-yl und tetrahydropyridin-4-yl)-benzofuran-7-carbamat derivate, ihre herstellung und verwendung als acetylcholinesterase inhibitoren
US5753683A (en) * 1993-08-19 1998-05-19 Novo Nordisk A/S Antipsychotic method
US5605908A (en) * 1994-10-24 1997-02-25 Eli Lilly And Company Heterocyclic compounds and their use
US5929247A (en) * 1994-10-24 1999-07-27 Eli Lilly And Company Heterocyclic compounds and their preparation and use
US5998404A (en) 1994-10-24 1999-12-07 Eli Lilly And Company Heterocyclic compounds and their use
US5574028A (en) * 1994-10-31 1996-11-12 Eli Lilly And Company Method for treating anxiety
US5726193A (en) * 1994-10-31 1998-03-10 Eli Lilly And Company Method for treating anxiety
US5488056A (en) * 1994-10-31 1996-01-30 Eli Lilly And Company Method for treating anxiety
AU7639598A (en) 1997-05-29 1998-12-30 H. Lundbeck A/S Treatment of schizophrenia and psychosis
WO1999032486A1 (en) * 1997-12-23 1999-07-01 Alcon Laboratories, Inc. Muscarinic agents and use thereof to treat glaucoma, myopia and various other conditions
US6107313A (en) * 1998-10-02 2000-08-22 Combichem, Inc. Dopamine receptor antagonists
US7332508B2 (en) 2002-12-18 2008-02-19 Novo Nordisk A/S Substituted homopiperidine, piperidine or pyrrolidine derivatives
US20070185100A1 (en) * 2004-02-18 2007-08-09 Astrazeneca Ab Poly-heterocyclic compounds and their use as metabotropic glutamate receptor antagonists
EP1720874A4 (de) * 2004-02-24 2010-03-03 Bioaxone Therapeutique Inc 4-substituierte piperidinderivate
US8084473B2 (en) 2007-04-24 2011-12-27 Solvay Pharmaceuticals B.V. Heterocyclic compounds with affinity to muscarinic receptors
MX2009011499A (es) * 2007-04-24 2009-11-09 Solvay Pharm Bv Compuestos heterociclicos con afinidad por los receptores muscarinicos.
WO2009140483A1 (en) 2008-05-15 2009-11-19 University Of Toledo Muscarinic agonists as cognitive enhancers
WO2012149524A1 (en) 2011-04-29 2012-11-01 The University Of Toledo Muscarinic agonists as enhancers of working memory and cognitive flexibility
US10106525B2 (en) 2015-01-26 2018-10-23 BioAxone BioSciences, Inc. Rho kinase inhibitor BA-1049 (R) and active metabolites thereof
US10857157B2 (en) 2015-01-26 2020-12-08 BioAxone BioSciences, Inc. Treatment of cerebral cavernous malformations and cerebral aneurysms with rho kinase inhibitors
US10149856B2 (en) 2015-01-26 2018-12-11 BioAxone BioSciences, Inc. Treatment of cerebral cavernous malformations and cerebral aneurysms with rho kinase inhibitors
US11198680B2 (en) 2016-12-21 2021-12-14 BioAxone BioSciences, Inc. Rho kinase inhibitor BA-1049 (R) and active metabolites thereof
US10537567B2 (en) 2017-07-11 2020-01-21 BioAxone BioSciences, Inc. Kinase inhibitors for treatment of disease
US20220152005A1 (en) * 2019-04-04 2022-05-19 Andrew Coop Methods of using muscarinic antagonists in the treatment of depression

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3966748A (en) * 1975-05-08 1976-06-29 American Cyanamid Company Para-fluorophenyl-N-heterocyclic substituted butanes
US4518601A (en) * 1982-06-16 1985-05-21 Ciba Geigy Corporation 2-(3-Pyridyl)-1,3,4-oxadiazoles and use thereof in pest control
NZ219646A (en) * 1986-03-27 1990-10-26 Merck Sharp & Dohme Oxadiazole derivatives of azacyclics for treating cns disorders

Also Published As

Publication number Publication date
PT85650A (en) 1987-10-01
EP0259621B1 (de) 1992-11-25
PH23584A (en) 1989-09-11
NZ221672A (en) 1990-09-26
US4837241A (en) 1989-06-06
AU603603B2 (en) 1990-11-22
IE872173L (en) 1989-03-08
IE62485B1 (en) 1995-02-08
EP0259621A2 (de) 1988-03-16
FI86424C (fi) 1992-08-25
NO169285B (no) 1992-02-24
NO873731D0 (no) 1987-09-07
GR3007053T3 (de) 1993-07-30
FI873809A0 (fi) 1987-09-02
ES2043624T3 (es) 1994-01-01
JPH0662616B2 (ja) 1994-08-17
NO169285C (no) 1992-06-03
JPS6377877A (ja) 1988-04-08
KR950009366B1 (ko) 1995-08-21
IL83275A (en) 1994-02-27
NO873731L (no) 1988-03-09
AU7816587A (en) 1988-03-31
PT85650B (pt) 1990-05-31
FI86424B (fi) 1992-05-15
CA1340937C (en) 2000-03-28
ATE82751T1 (de) 1992-12-15
US4933353A (en) 1990-06-12
FI873809A (fi) 1988-03-09
IL83275A0 (en) 1987-12-31
KR880003939A (ko) 1988-06-01
DE3782785D1 (de) 1993-01-07
EP0259621A3 (en) 1988-10-12

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee