DE3779856D1 - Antibakterielle, 2-substituierte alkyl-carbapeneme. - Google Patents

Antibakterielle, 2-substituierte alkyl-carbapeneme.

Info

Publication number
DE3779856D1
DE3779856D1 DE8787308873T DE3779856T DE3779856D1 DE 3779856 D1 DE3779856 D1 DE 3779856D1 DE 8787308873 T DE8787308873 T DE 8787308873T DE 3779856 T DE3779856 T DE 3779856T DE 3779856 D1 DE3779856 D1 DE 3779856D1
Authority
DE
Germany
Prior art keywords
carbapeneme
antibacterial
substituted alkyl
substituted
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8787308873T
Other languages
English (en)
Other versions
DE3779856T2 (de
Inventor
Ronald W Ratcliffe
Mary F Woods
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE3779856D1 publication Critical patent/DE3779856D1/de
Publication of DE3779856T2 publication Critical patent/DE3779856T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE8787308873T 1986-10-16 1987-10-07 Antibakterielle, 2-substituierte alkyl-carbapeneme. Expired - Fee Related DE3779856T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91972586A 1986-10-16 1986-10-16

Publications (2)

Publication Number Publication Date
DE3779856D1 true DE3779856D1 (de) 1992-07-23
DE3779856T2 DE3779856T2 (de) 1993-03-25

Family

ID=25442542

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787308873T Expired - Fee Related DE3779856T2 (de) 1986-10-16 1987-10-07 Antibakterielle, 2-substituierte alkyl-carbapeneme.

Country Status (3)

Country Link
EP (1) EP0265117B1 (de)
JP (1) JPS63126879A (de)
DE (1) DE3779856T2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5132300A (en) * 1989-06-01 1992-07-21 Pfizer Inc. Beta-lactam elastase inhibitors
US5258509A (en) * 1989-11-21 1993-11-02 Banyu Pharmaceutical Co., Ltd. Process for producing 2-carbon-substituted carbapenem derivatives
EP0430037A3 (en) * 1989-11-21 1992-05-27 Banyu Pharmaceutical Co., Ltd. Process for producing 2-carbon-substituted carbapenem derivatives
US5068232A (en) * 1990-04-10 1991-11-26 American Cyanamid Company Novel 2-substituted alkyl-3-carboxy carbapenems as antibiotics and a method of producing them

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59106489A (ja) * 1982-12-10 1984-06-20 Sanraku Inc 新規β−ラクタム誘導体及びその製造方法

Also Published As

Publication number Publication date
DE3779856T2 (de) 1993-03-25
EP0265117A1 (de) 1988-04-27
EP0265117B1 (de) 1992-06-17
JPS63126879A (ja) 1988-05-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee