DE3769872D1 - Herstellung von rekombinantem protein. - Google Patents
Herstellung von rekombinantem protein.Info
- Publication number
- DE3769872D1 DE3769872D1 DE8787109276T DE3769872T DE3769872D1 DE 3769872 D1 DE3769872 D1 DE 3769872D1 DE 8787109276 T DE8787109276 T DE 8787109276T DE 3769872 T DE3769872 T DE 3769872T DE 3769872 D1 DE3769872 D1 DE 3769872D1
- Authority
- DE
- Germany
- Prior art keywords
- production
- recombinant protein
- lipoprotein
- culturing
- enhanced
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Revoked
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88441286A | 1986-07-11 | 1986-07-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3769872D1 true DE3769872D1 (de) | 1991-06-13 |
Family
ID=25384571
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8787109276T Revoked DE3769872D1 (de) | 1986-07-11 | 1987-06-27 | Herstellung von rekombinantem protein. |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0254076B1 (de) |
JP (1) | JPH0630610B2 (de) |
AT (1) | ATE63335T1 (de) |
DE (1) | DE3769872D1 (de) |
DK (1) | DK359487A (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5198349A (en) * | 1986-01-03 | 1993-03-30 | Genetics Institute, Inc. | Method for producing factor VIII:C and analogs |
JP2525022B2 (ja) * | 1986-01-03 | 1996-08-14 | ジェネティックス・インスチチュ−ト・インコ−ポレ−テッド | ▲VIII▼:c因子型タンパク質の改良生産方法 |
US5595886A (en) * | 1986-01-27 | 1997-01-21 | Chiron Corporation | Protein complexes having Factor VIII:C activity and production thereof |
US6060447A (en) * | 1987-05-19 | 2000-05-09 | Chiron Corporation | Protein complexes having Factor VIII:C activity and production thereof |
JP3045307B2 (ja) * | 1989-08-11 | 2000-05-29 | ザイモジェネティクス,インコーポレイティド | 活性化プロテインcを生成するための細胞培養法 |
FR2657884B1 (fr) * | 1990-02-05 | 1994-09-02 | Tm Innovation | Procede pour la preparation du facteur viii humain et d'analogues du facteur viii. |
DK53792D0 (da) * | 1992-04-24 | 1992-04-24 | Novo Nordisk As | Fremgangsmaade til fremstilling af proteiner |
EP0679192A1 (de) * | 1992-11-17 | 1995-11-02 | Novo Nordisk A/S | Verbesserte rekombinante produktion von proteinen welche faktor viii:c aktivität haben |
US5952198A (en) * | 1995-05-04 | 1999-09-14 | Bayer Corporation | Production of recombinant Factor VIII in the presence of liposome-like substances of mixed composition |
US6358703B1 (en) | 1998-12-10 | 2002-03-19 | Bayer Corporation | Expression system for factor VIII |
EP1707634A1 (de) | 2005-03-29 | 2006-10-04 | Octapharma AG | Verfahren zur Isolierung von rekombinant hergestellten Proteinen |
EP1739179A1 (de) | 2005-06-30 | 2007-01-03 | Octapharma AG | Serumfreie stabile Transfektion und Produktion von rekombinanten humanen Proteinen in humanen Zelllinien |
EP1988101A1 (de) * | 2007-05-04 | 2008-11-05 | Novo Nordisk A/S | Verbesserung von Faktor-VIII-Polypeptid-Titern in Zellkulturen |
WO2011095604A1 (en) | 2010-02-04 | 2011-08-11 | Octapharma Biopharmaceuticals Gmbh | Half-life prolongation of proteins |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2125409B (en) | 1982-08-04 | 1985-11-13 | Nat Res Dev | Genetic engineering |
EP0162067B1 (de) | 1983-10-28 | 1992-07-15 | Genetics Institute, Inc. | Herstellung des faktors viii und damit verwandte erzeugnisse |
DE3588242T2 (de) | 1984-01-12 | 2004-03-11 | Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville | Für Faktor-VIIIc kodierende DNA-Sequenzen und verwandte DNA-Konstruktionen |
ZA852099B (en) | 1984-03-26 | 1985-12-24 | Meloy Lab | Recombinant factor viii-c. |
FI86885C (fi) * | 1984-04-20 | 1992-10-26 | Genentech Inc | Foerfarande foer framstaellning av human rekombinantfaktor viii och nukleinsyrasekvenser och vektorer anvaend daertill |
JPS6163283A (ja) * | 1984-09-03 | 1986-04-01 | Teijin Ltd | ハイブリ−ド−マの培養方法 |
-
1987
- 1987-06-27 DE DE8787109276T patent/DE3769872D1/de not_active Revoked
- 1987-06-27 EP EP87109276A patent/EP0254076B1/de not_active Expired - Lifetime
- 1987-06-27 AT AT87109276T patent/ATE63335T1/de not_active IP Right Cessation
- 1987-07-09 JP JP62169926A patent/JPH0630610B2/ja not_active Expired - Lifetime
- 1987-07-10 DK DK359487A patent/DK359487A/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JPS6342699A (ja) | 1988-02-23 |
DK359487A (da) | 1988-01-12 |
DK359487D0 (da) | 1987-07-10 |
ATE63335T1 (de) | 1991-05-15 |
EP0254076A1 (de) | 1988-01-27 |
JPH0630610B2 (ja) | 1994-04-27 |
EP0254076B1 (de) | 1991-05-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent | ||
8331 | Complete revocation |