DE3769502D1 - Phenyl- und heterocyclische tetrahydropyridyl- und piperazinyl-alkoxy-benzheterocyclische verbindungen als antipsychotische heilmittel. - Google Patents

Phenyl- und heterocyclische tetrahydropyridyl- und piperazinyl-alkoxy-benzheterocyclische verbindungen als antipsychotische heilmittel.

Info

Publication number
DE3769502D1
DE3769502D1 DE8787101928T DE3769502T DE3769502D1 DE 3769502 D1 DE3769502 D1 DE 3769502D1 DE 8787101928 T DE8787101928 T DE 8787101928T DE 3769502 T DE3769502 T DE 3769502T DE 3769502 D1 DE3769502 D1 DE 3769502D1
Authority
DE
Germany
Prior art keywords
benzheterocyclic
tetrahydropyridyl
piperazinyl
heterocyclic
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8787101928T
Other languages
English (en)
Inventor
Bradley W Caprathe
Horace A Dewald
Juan C Jaen
Lawrence D Wise
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of DE3769502D1 publication Critical patent/DE3769502D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE8787101928T 1986-02-13 1987-02-12 Phenyl- und heterocyclische tetrahydropyridyl- und piperazinyl-alkoxy-benzheterocyclische verbindungen als antipsychotische heilmittel. Expired - Fee Related DE3769502D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82903686A 1986-02-13 1986-02-13
US06/924,627 US4704390A (en) 1986-02-13 1986-11-05 Phenyl and heterocyclic tetrahydropyridyl alkoxy-benzheterocyclic compounds as antipsychotic agents

Publications (1)

Publication Number Publication Date
DE3769502D1 true DE3769502D1 (de) 1991-05-29

Family

ID=27125236

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787101928T Expired - Fee Related DE3769502D1 (de) 1986-02-13 1987-02-12 Phenyl- und heterocyclische tetrahydropyridyl- und piperazinyl-alkoxy-benzheterocyclische verbindungen als antipsychotische heilmittel.

Country Status (6)

Country Link
US (1) US4704390A (de)
EP (1) EP0237781B1 (de)
CA (1) CA1280750C (de)
DE (1) DE3769502D1 (de)
ES (1) ES2028802T3 (de)
GR (1) GR3001853T3 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4806552A (en) * 1980-03-01 1989-02-21 John Wyeth & Brother, Limited Pyridyl- and/or pyridoyl-(piperid-4-yl) ureas and analogues thereof
EP0233728A1 (de) * 1986-02-11 1987-08-26 Takeda Chemical Industries, Ltd. 1,4-Benzoxazin-Derivate, ihre Herstellung und Verwendung
US4788290A (en) * 1987-12-11 1988-11-29 American Home Products Corporation Serotonergic pyrazine derivatives
JP2779240B2 (ja) * 1987-12-11 1998-07-23 三井化学株式会社 新規アミン類およびその用途
SE8803429D0 (sv) * 1988-09-28 1988-09-28 Pharmacia Ab Novel pyridyl- and pyrimidyl derivatives
US5149817A (en) * 1990-03-05 1992-09-22 Shionogi & Co., Ltd. Teirahydropyridine derivatives
US5332733A (en) * 1990-11-24 1994-07-26 Kali-Chemie Pharma Gmbh Heterocyclically substituted piperazinoakylbenzoxazine and piperazinoalkylbenzothiazine compounds, processes for preparing them, and medicaments containing them
US5235055A (en) * 1992-09-02 1993-08-10 American Home Products Corporation Antipsychotic quinoline derivatives of benzodioxanmethylamine
US5245051A (en) * 1992-09-03 1993-09-14 American Home Products Corporation Antipsychotic chroman derivatives of benzodioxanmethylamine
WO1996010571A1 (en) * 1994-09-30 1996-04-11 Pfizer Inc. 2,7-SUBSTITUTED OCTAHYDRO-1H-PYRIDO[1,2-a]PYRAZINE DERIVATIVES
US5741789A (en) * 1995-01-17 1998-04-21 Eli Lilly And Company Compounds having effects on serotonin-related systems
US5576321A (en) * 1995-01-17 1996-11-19 Eli Lilly And Company Compounds having effects on serotonin-related systems
EP0913395A1 (de) * 1995-12-08 1999-05-06 Ube Industries, Ltd. N-phenylcarbamat-verbindungen, verfahren zu ihrer herstellung und bakterizide fur landwirtschaft und gartenbau
AU746717B2 (en) * 1997-02-18 2002-05-02 Wyeth 4-aminoalkoxy-1H-benzimidazole derivatives, their preparation and their use as dopamine autoreceptor (D2) agonists
US6127380A (en) * 1997-02-18 2000-10-03 American Home Products Corporation 4-aminoalkoxy-1H-benzoimidazoles
EA004508B1 (ru) * 1999-10-22 2004-04-29 Санофи-Синтелябо Фенил- и пиридил-тетрагидропиридины, обладающие ингибирующей активностью в отношении фактора некроза опухоли (фно)
SE9903997D0 (sv) * 1999-11-03 1999-11-03 Astra Ab New compounds
SE9903998D0 (sv) 1999-11-03 1999-11-03 Astra Ab New compounds
DE10041574A1 (de) * 2000-08-24 2002-03-07 Merck Patent Gmbh Chromenonderivate
US7314937B2 (en) * 2002-03-21 2008-01-01 Eli Lilly And Company Non-imidazole aryl alkylamines compounds as histamine H3 receptor antagonists, preparation and therapeutic uses
AU2003260882A1 (en) * 2002-09-26 2004-04-19 Warner-Lambert Company Llc Heterocyclic substituted piperazines for the treatment of schizophrenia
EP1687299A1 (de) * 2003-11-20 2006-08-09 Eli Lilly And Company Heterocyclische verbindungen als modulatoren von durch den peroxisomproliferator aktivierten rezeptoren, die sich zur behandlung und/oder prävention von durch einen ppar modulierten erkrankungen eignen
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
CN104059046B (zh) * 2013-03-18 2017-02-08 江苏恩华药业股份有限公司 黄酮类衍生物及其应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2337461A1 (de) * 1973-07-24 1975-02-06 Boehringer Mannheim Gmbh Neue indolderivate und verfahren zu deren herstellung
NL7513616A (en) * 1975-11-21 1977-05-24 Beecham Group Ltd (Thio)chroman and tetralin basic ethers - with anorexigenic and antidepressant activity
IL48897A (en) * 1976-01-23 1979-05-31 Beecham Group Ltd 2,2-dimethyl-7-(dialkylaminoethoxy)-4-naphthyl-chroman or-naphthalene derivatives,their preparation and pharmaceutical compositions containing them
WO1980000152A1 (en) * 1978-07-03 1980-02-07 Sandoz Ag 3-aminopropoxy-aryl derivates,preparation and use thereof
DE2901336A1 (de) * 1979-01-15 1980-07-24 Boehringer Mannheim Gmbh Neue arylether, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
DE3034237A1 (de) * 1979-09-18 1981-04-16 Otsuka Pharmaceutical Co. Ltd., Tokyo Carbostyrilderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende, antihistaminisch wirkende mittel
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
DE3236243A1 (de) * 1982-09-30 1984-04-05 Merck Patent Gmbh, 6100 Darmstadt Schwefelhaltige indolderivate
JPS5970675A (ja) * 1982-10-15 1984-04-21 Otsuka Pharmaceut Co Ltd ベンゾオキサジン誘導体
DE3427985A1 (de) * 1984-07-28 1986-01-30 Boehringer Mannheim Gmbh, 6800 Mannheim Neue 2h-l-benzopyran-2-on-derivate, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
US4701456A (en) * 1984-09-19 1987-10-20 Warner-Lambert Company Aminoalkoxybenzopyranones as antipsychotic and anxiolytic agents
US4678787A (en) * 1985-01-30 1987-07-07 Warner-Lambert Company 4H-1-benzopyran-4-ones and their sulfur containing analogs

Also Published As

Publication number Publication date
CA1280750C (en) 1991-02-26
ES2028802T3 (es) 1992-07-16
US4704390A (en) 1987-11-03
EP0237781A3 (en) 1987-12-16
EP0237781A2 (de) 1987-09-23
EP0237781B1 (de) 1991-04-24
GR3001853T3 (en) 1992-11-23

Similar Documents

Publication Publication Date Title
DE3769502D1 (de) Phenyl- und heterocyclische tetrahydropyridyl- und piperazinyl-alkoxy-benzheterocyclische verbindungen als antipsychotische heilmittel.
DE3769049D1 (de) Heterocyclische verbindungen.
DE3881970D1 (de) Heterocyclische verbindungen.
DE69005858T3 (de) Heterocyclische Verbindungen.
DE3856434D1 (de) Benzoheterocyclische Verbindungen
NO893304L (no) Heterocykliske forbindelser.
DK93887A (da) Heterocycliske forbindelser
NL970016I2 (nl) Heterocyclische verbindingen.
NO861080L (no) Heterosykliske forbindelser.
DE3682711D1 (de) Als fungizide verwendbare heterocyclische verbindungen.
NO872039D0 (no) Nitrogenholdige heterocykliske forbindelser.
FI871632A (fi) Heterocykliska karboxamider.
DK287688D0 (da) Heterocycliske forbindelser
NO883613L (no) Heterocykliske forbindelser.
DK227487A (da) Substituerede heterocycliske forbindelser
DE3884007D1 (de) Arylpiperazinylalkylenphenylheterocyclische Verbindungen.
DE68924751D1 (de) Azacyclische Verbindungen, verwendbar als Arzneimittel.
NO880553D0 (no) Heterosykliske forbindelser.
DE3682873D1 (de) Heterocyclische verbindungen.
DK499987D0 (da) Heterocycliske forbindelser
DE3575720D1 (de) Heterocyclische verbindungen.
DE3783951D1 (de) Heterozyklische verbindungen.
IT8619233A0 (it) Composti eterociclici.
ATE123280T1 (de) Heterocyclische verbindungen.
ATE85329T1 (de) Heterozyklische verbindungen.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee