DE3767839D1 - Pyrrolidinamid-derivate mit antipropylendopeptidase-wirkung, zusammenstellungen, die sie enthalten, verfahren zu ihrer herstellung und heilmittel, die sie enthalten. - Google Patents
Pyrrolidinamid-derivate mit antipropylendopeptidase-wirkung, zusammenstellungen, die sie enthalten, verfahren zu ihrer herstellung und heilmittel, die sie enthalten.Info
- Publication number
- DE3767839D1 DE3767839D1 DE8787117003T DE3767839T DE3767839D1 DE 3767839 D1 DE3767839 D1 DE 3767839D1 DE 8787117003 T DE8787117003 T DE 8787117003T DE 3767839 T DE3767839 T DE 3767839T DE 3767839 D1 DE3767839 D1 DE 3767839D1
- Authority
- DE
- Germany
- Prior art keywords
- derivatives
- production
- antipropylene
- opeptidase
- pyrrolidinamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP61274355A JPH08806B2 (ja) | 1986-11-18 | 1986-11-18 | プロリルエンドペプチダ−ゼ阻害作用を有する新規ピロリジンアミド誘導体 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3767839D1 true DE3767839D1 (de) | 1991-03-07 |
Family
ID=17540501
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8787117003T Expired - Lifetime DE3767839D1 (de) | 1986-11-18 | 1987-11-17 | Pyrrolidinamid-derivate mit antipropylendopeptidase-wirkung, zusammenstellungen, die sie enthalten, verfahren zu ihrer herstellung und heilmittel, die sie enthalten. |
Country Status (9)
Country | Link |
---|---|
US (1) | US4810721A (de) |
EP (1) | EP0268281B1 (de) |
JP (1) | JPH08806B2 (de) |
AT (1) | ATE60579T1 (de) |
AU (1) | AU591860B2 (de) |
CA (1) | CA1326033C (de) |
DE (1) | DE3767839D1 (de) |
ES (1) | ES2036562T3 (de) |
GR (1) | GR3001405T3 (de) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3712365A1 (de) * | 1987-04-11 | 1988-10-27 | Hoechst Ag | Neue 2-acylpyrrolidin-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel sowie deren verwendung |
DE3712364A1 (de) * | 1987-04-11 | 1988-10-27 | Hoechst Ag | Neue pyrrolidin-2-(1,3-dicarbonyl)-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel sowie deren verwendung |
CA2004028C (en) * | 1988-12-08 | 1998-09-22 | Motoki Torizuka | Condensed benzene derivative |
EP0419683A4 (en) * | 1989-04-13 | 1992-03-11 | Japan Tobacco Inc. | New amino acid derivatives having prolylendopeptidase inhibitor activity |
US5073549A (en) * | 1990-03-22 | 1991-12-17 | Bristol-Myers Squibb Company | BU-4164E - A and B, prolyl endopeptidase inhibitors and their methods of use |
US4999349A (en) * | 1990-03-22 | 1991-03-12 | Bristol-Myers Squibb Co. | BU-4164E - A and B, prolyl endopeptidase inhibitors |
US5506256A (en) * | 1990-07-27 | 1996-04-09 | Yoshitomi Pharmaceutical Industries, Ltd. | Proline derivatives possessing prolyl endopeptidase-inhibitory activity |
IT1249728B (it) * | 1991-11-06 | 1995-03-09 | Sigma Tau Ind Farmaceuti | Derivati delle prolinammide quali attivatori della memoria e dei processi di apprendimento e composizioni farmaceutiche che li contengono |
IT1254471B (it) * | 1992-02-27 | 1995-09-25 | Magis Farmaceutici | Derivati ammidici della (r)-glicerofosforil-(s)-serina o del suo diacil derivato, un processo per la loro preparazione e relative composizioni farmaceutiche per il potenziamento dei processi di apprendimento |
JP3810097B2 (ja) * | 1993-01-15 | 2006-08-16 | 明治製菓株式会社 | ピロリジン−2−イルカルボニル複素環式化合物誘導体 |
DE602004026289D1 (de) | 2003-05-05 | 2010-05-12 | Probiodrug Ag | Glutaminylcyclase-hemmer |
ZA200603165B (en) | 2003-11-03 | 2007-07-25 | Probiodrug Ag | Combinations useful for the treatment of neuronal disorders |
AU2005210004B2 (en) | 2004-02-05 | 2010-10-28 | Probiodrug Ag | Novel inhibitors of glutaminyl cyclase |
WO2008055945A1 (en) | 2006-11-09 | 2008-05-15 | Probiodrug Ag | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
WO2008065141A1 (en) | 2006-11-30 | 2008-06-05 | Probiodrug Ag | Novel inhibitors of glutaminyl cyclase |
ZA200905537B (en) | 2007-03-01 | 2010-10-27 | Probiodrug Ag | New use of glutaminyl cyclase inhibitors |
JP5667440B2 (ja) | 2007-04-18 | 2015-02-12 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体 |
US8524654B2 (en) * | 2007-05-21 | 2013-09-03 | The Uab Research Foundation | Prolyl endopeptidase inhibitors for reducing or preventing neutrophilic inflammation |
MX2012002993A (es) | 2009-09-11 | 2012-04-19 | Probiodrug Ag | Derivados heterociclicos como inhibidores de ciclasa glutaminilo. |
JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
MX2012010470A (es) | 2010-03-10 | 2012-10-09 | Probiodrug Ag | Inhibidores heterociclicos d ciclasa de glutaminilo (qc, ec .3 2. 5). |
US8541596B2 (en) | 2010-04-21 | 2013-09-24 | Probiodrug Ag | Inhibitors |
WO2012123563A1 (en) | 2011-03-16 | 2012-09-20 | Probiodrug Ag | Benz imidazole derivatives as inhibitors of glutaminyl cyclase |
EP3461819B1 (de) | 2017-09-29 | 2020-05-27 | Probiodrug AG | Hemmer der glutaminylcyclase |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4483991A (en) * | 1983-01-17 | 1984-11-20 | American Home Products Corporation | Hypotensive agents |
JPS60172929A (ja) * | 1984-02-17 | 1985-09-06 | Yakult Honsha Co Ltd | 抗健忘症剤 |
JPS60188317A (ja) * | 1984-03-09 | 1985-09-25 | Yakult Honsha Co Ltd | 抗健忘症剤 |
JPS6137764A (ja) * | 1984-07-31 | 1986-02-22 | Suntory Ltd | 抗プロリルエンドペプチダ−ゼ活性を有する新規生理活性化合物 |
IN164086B (de) * | 1984-10-23 | 1989-01-14 | Siemens Ag | |
JPH0680077B2 (ja) * | 1985-02-08 | 1994-10-12 | サントリー株式会社 | プロリンエンドペプチダ−ゼインヒビタ−活性を有する新規ペプチド化合物 |
JPH0623190B2 (ja) * | 1985-04-16 | 1994-03-30 | サントリー株式会社 | インヒビタ−活性を有するn−アシルピロリジン誘導体及びその製法並びに用途 |
JPH0651677B2 (ja) * | 1985-12-23 | 1994-07-06 | サントリー株式会社 | ジペプチド誘導体及びその製法並びに用途 |
JPH0764834B2 (ja) * | 1985-11-29 | 1995-07-12 | サントリー株式会社 | プロリルエンドペプチダーゼ阻害活性を有する新規ピロリジンアミド誘導体およびその製法並びに用途 |
DE3780344T2 (de) * | 1986-03-27 | 1993-01-28 | Sumitomo Pharma | Beta-lactam-verbindungen und deren herstellung. |
JPH0780883B2 (ja) * | 1986-03-27 | 1995-08-30 | 住友製薬株式会社 | 新規なβ−ラクタム化合物 |
-
1986
- 1986-11-18 JP JP61274355A patent/JPH08806B2/ja not_active Expired - Lifetime
-
1987
- 1987-11-13 CA CA000551797A patent/CA1326033C/en not_active Expired - Fee Related
- 1987-11-17 EP EP87117003A patent/EP0268281B1/de not_active Expired - Lifetime
- 1987-11-17 DE DE8787117003T patent/DE3767839D1/de not_active Expired - Lifetime
- 1987-11-17 ES ES198787117003T patent/ES2036562T3/es not_active Expired - Lifetime
- 1987-11-17 AT AT87117003T patent/ATE60579T1/de not_active IP Right Cessation
- 1987-11-17 US US07/121,887 patent/US4810721A/en not_active Expired - Fee Related
- 1987-11-18 AU AU81336/87A patent/AU591860B2/en not_active Ceased
-
1991
- 1991-01-31 GR GR90400722T patent/GR3001405T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
JPS63130579A (ja) | 1988-06-02 |
EP0268281B1 (de) | 1991-01-30 |
US4810721A (en) | 1989-03-07 |
AU8133687A (en) | 1988-05-19 |
JPH08806B2 (ja) | 1996-01-10 |
ES2036562T3 (es) | 1993-06-01 |
GR3001405T3 (en) | 1992-09-25 |
CA1326033C (en) | 1994-01-11 |
EP0268281A2 (de) | 1988-05-25 |
EP0268281A3 (en) | 1989-01-18 |
AU591860B2 (en) | 1989-12-14 |
ATE60579T1 (de) | 1991-02-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE3767839D1 (de) | Pyrrolidinamid-derivate mit antipropylendopeptidase-wirkung, zusammenstellungen, die sie enthalten, verfahren zu ihrer herstellung und heilmittel, die sie enthalten. | |
ATE25974T1 (de) | Acyl-substituierte derivate von 1,2,3,4tetrahydroisochinolin-3-carboxysaeuren, ihre salze, diese enthaltende arzneimittel und verfahren zu ihrer herstellung. | |
MX9604378A (es) | Amidas de acido quinolin-2-carboxilico sustituidas, su preparacion y su empleo como medicamentos, asi como productos intermedios. | |
ATE133667T1 (de) | Thiazolderivate, verfahren zur ihrer herstellung und pharmazeutische zusammensetzungen, die sie enthalten | |
FR2371436A1 (fr) | Nouveaux derives de morpholine ou de piperidine utiles comme medicaments et comme fongicides | |
IL123002A0 (en) | 1-Phenyl-2- phenylacetoxy- ethanone derivatives | |
HUT40811A (en) | Process for preparing difluoro-ketone-peptide derivatives | |
HUT42080A (en) | Process for producing labdane derivatives and pharmaceutical compositions containing them | |
ATE302778T1 (de) | N-substituierte 4-aminopteridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel | |
KR0148213B1 (en) | Phenyla lkan(en)oic acid and pharmaceutical composition comprising the same | |
ZA806399B (en) | New 2-hydroxyalkyl-3,4,5-trihydroxypiperidine compounds, their production and their medicinal use | |
MY105538A (en) | Derivatives of thieno-triazolo-diazepine, a preparation process of the same and therapeutic compositions containing them. | |
DE3476392D1 (en) | Purine derivatives | |
AU6306190A (en) | Novel substituted alkyl piperidines and their use as inhibitors of cholesterol synthesis | |
DE3768529D1 (de) | Isohexid-nukleoside, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel. | |
ITMI920082A1 (it) | Derivati solforati di acidi biliari | |
DE68920022T2 (de) | Indolessigsäure-derivate, verfahren zur herstellung sowie arzneimittel, die diese als aktive mittel enthalten. | |
IL106934A (en) | Heteroarenylpiperazines a process for their preparation and pharmaceutical compositions comprising them | |
ATE49003T1 (de) | Pregnane derivate, verfahren zu ihrer herstellung und pharmazeutische zusammenstellungen, die sie enthalten. | |
ATE3295T1 (de) | Clavulansaeure-derivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische praeparate. | |
DE3784883D1 (de) | Fluor enthaltende makrolid-verbindungen, pharmazeutische zusammensetzungen, welche diese enthalten und ihre verwendung fuer die herstellung von arzneimitteln. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |