DE3751908T2 - Chimärisches Murine-Mensch-Immunoglobulin, spezifisch für tumorassoziertes 17-1A Antigen - Google Patents
Chimärisches Murine-Mensch-Immunoglobulin, spezifisch für tumorassoziertes 17-1A AntigenInfo
- Publication number
- DE3751908T2 DE3751908T2 DE3751908T DE3751908T DE3751908T2 DE 3751908 T2 DE3751908 T2 DE 3751908T2 DE 3751908 T DE3751908 T DE 3751908T DE 3751908 T DE3751908 T DE 3751908T DE 3751908 T2 DE3751908 T2 DE 3751908T2
- Authority
- DE
- Germany
- Prior art keywords
- murine
- specific
- antigen
- tumor
- human chimeric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1084—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin
- A61K51/1087—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin the immunoglobulin comprises domains from different animal species, e.g. chimeric immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3046—Stomach, Intestines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88249286A | 1986-07-07 | 1986-07-07 | |
US6941487A | 1987-07-01 | 1987-07-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3751908D1 DE3751908D1 (de) | 1996-10-24 |
DE3751908T2 true DE3751908T2 (de) | 1997-02-06 |
Family
ID=26750032
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3751908T Expired - Lifetime DE3751908T2 (de) | 1986-07-07 | 1987-07-07 | Chimärisches Murine-Mensch-Immunoglobulin, spezifisch für tumorassoziertes 17-1A Antigen |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0256654B1 (de) |
JP (1) | JPH1070991A (de) |
AT (1) | ATE143052T1 (de) |
CA (1) | CA1340456C (de) |
DE (1) | DE3751908T2 (de) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5336603A (en) * | 1987-10-02 | 1994-08-09 | Genentech, Inc. | CD4 adheson variants |
US6710169B2 (en) | 1987-10-02 | 2004-03-23 | Genentech, Inc. | Adheson variants |
GB8800077D0 (en) * | 1988-01-05 | 1988-02-10 | Ciba Geigy Ag | Novel chimeric antibodies |
US5843708A (en) * | 1988-01-05 | 1998-12-01 | Ciba-Geigy Corporation | Chimeric antibodies |
US5750375A (en) * | 1988-01-22 | 1998-05-12 | Zymogenetics, Inc. | Methods of producing secreted receptor analogs and biologically active dimerized polypeptide fusions |
US5567584A (en) * | 1988-01-22 | 1996-10-22 | Zymogenetics, Inc. | Methods of using biologically active dimerized polypeptide fusions to detect PDGF |
EP0325224B1 (de) * | 1988-01-22 | 1996-07-31 | ZymoGenetics, Inc. | Verfahren zur Herstellung von sekretierten Rezeptoranalogen |
US6018026A (en) * | 1988-01-22 | 2000-01-25 | Zymogenetics, Inc. | Biologically active dimerized and multimerized polypeptide fusions |
US4975369A (en) * | 1988-04-21 | 1990-12-04 | Eli Lilly And Company | Recombinant and chimeric KS1/4 antibodies directed against a human adenocarcinoma antigen |
US5290914A (en) * | 1988-04-28 | 1994-03-01 | Mycogen Corporation | Hybrid diphtheria-B.t. pesticidal toxins |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
PT92900A (pt) * | 1989-01-24 | 1990-07-31 | Sistema de vectores de expressao para a producao de anticorpos monoclonais quimericos | |
US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
CA2077348A1 (en) * | 1990-03-02 | 1991-09-03 | Stephen D. Gillies | Antibody constructs with enhanced binding affinity |
EP0528767B1 (de) * | 1991-08-21 | 2000-01-12 | Novartis AG | Antikörperderivate |
DE4133791A1 (de) * | 1991-10-11 | 1993-04-15 | Behringwerke Ag | Monoklonale antikoerper gegen tumorassoziierte antigene, verfahren zu ihrer herstellung und ihre verwendung |
US5635177A (en) | 1992-01-22 | 1997-06-03 | Genentech, Inc. | Protein tyrosine kinase agonist antibodies |
US6030797A (en) * | 1992-10-08 | 2000-02-29 | Dade Behring Marburg Gmbh | Monoclonal antibodies against tumor-associated antigens, processes for the preparation thereof and the use thereof |
US5877016A (en) | 1994-03-18 | 1999-03-02 | Genentech, Inc. | Human trk receptors and neurotrophic factor inhibitors |
DE19543039C1 (de) * | 1995-11-08 | 1996-11-21 | Medac Klinische Spezialpraep | Rekombinante Liganden für das menschliche Zellmembran-Antigen CD30 |
US6100071A (en) | 1996-05-07 | 2000-08-08 | Genentech, Inc. | Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production |
US7282205B2 (en) | 2001-11-07 | 2007-10-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Anti-hepatitis A virus antibodies |
ES2528384T3 (es) | 2001-12-12 | 2015-02-09 | The Government Of The United States Of America, As Represented By The Secretary Department Of Healt | Métodos de utilización de inhibidores del receptor de adenosina para potenciar la respuesta inmunitaria y la inflamación |
MXPA05003049A (es) | 2002-09-19 | 2005-11-17 | Us Gov Health & Human Serv | Polipeptidos de phlebotomus ariasi, polipeptidos de phlebotomus perniciosus y metodos de uso. |
ES2447843T3 (es) | 2002-10-29 | 2014-03-13 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Polip�ptidos de Lutzomyia longipalpis y m�todos de uso |
TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
ES2432091T5 (es) | 2005-03-25 | 2022-03-18 | Gitr Inc | Moléculas de unión GITR y usos de las mismas |
ES2547463T3 (es) | 2005-06-17 | 2015-10-06 | Merck Sharp & Dohme Corp. | Moléculas de unión a ILT3 y usos de las mismas |
EP2397852B1 (de) | 2006-03-14 | 2013-12-04 | Oregon Health and Science University | Methoden zur Detektion einer Mycobakterium tuberculosis Infektion |
US7777008B2 (en) | 2006-06-19 | 2010-08-17 | Tolerx, Inc. | ILT3 binding molecules and uses therefor |
EP2444410A3 (de) | 2007-02-28 | 2012-08-08 | The Govt. Of U.S.A. As Represented By The Secretary Of The Department Of Health And Human Services | Brachyurie-Polypeptide und Verwendungsverfahren |
ES2591281T3 (es) | 2007-07-12 | 2016-11-25 | Gitr, Inc. | Terapias de combinación que emplean moléculas de enlazamiento a GITR |
AU2009294850B2 (en) | 2008-09-22 | 2015-07-02 | Oregon Health & Science University | Methods for detecting a Mycobacterium tuberculosis infection |
US8664183B2 (en) | 2009-02-27 | 2014-03-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | SPANX-B polypeptides and their use |
US9181306B2 (en) | 2009-10-16 | 2015-11-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Insertion of foreign genes in rubella virus and their stable expression in a live, attenuated viral vaccine |
CN102713629B (zh) | 2009-11-20 | 2016-02-24 | 俄勒冈健康科学大学 | 用于检测结核分枝杆菌感染的方法 |
EP2591006B1 (de) | 2010-07-09 | 2019-04-24 | Bioverativ Therapeutics Inc. | Verarbeitbare einkettige moleküle und daraus hergestellte polypeptide |
AU2011295722B2 (en) | 2010-09-03 | 2016-04-21 | Abbvie Stemcentrx Llc | Identification and enrichment of cell subpopulations |
WO2013119964A2 (en) | 2012-02-08 | 2013-08-15 | Stem Centrx, Inc. | Identification and enrichment of cell subpopulations |
ES2703780T3 (es) | 2011-05-17 | 2019-03-12 | Trion Res Gmbh | Preparación de una vacuna que contiene anticuerpos trifuncionales con propiedades potenciadoras de la inmunogenicidad del antígeno |
EP2524699A1 (de) | 2011-05-17 | 2012-11-21 | Trion Research GmbH | Impfstoffzubereitung mit trifunktionalen Antikörpern mit Antigenimmunogenität verbessernden Eigenschaften |
WO2012170969A2 (en) | 2011-06-10 | 2012-12-13 | Biogen Idec Ma Inc. | Pro-coagulant compounds and methods of use thereof |
US9738707B2 (en) | 2011-07-15 | 2017-08-22 | Biogen Ma Inc. | Heterodimeric Fc regions, binding molecules comprising same, and methods relating thereto |
EP2748198A2 (de) | 2011-09-27 | 2014-07-02 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Verfahren zur behandlung von multipler sklerose mittels intrathekalen abreicherung von b-zellen und biomarkern zur auswahl von patienten mit progressiver multipler sklerose |
PL2802606T3 (pl) | 2012-01-10 | 2018-09-28 | Biogen Ma Inc. | Udoskonalenie transportu cząsteczek terapeutycznych przez barierę krew-mózg |
US9566329B2 (en) | 2012-04-06 | 2017-02-14 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Live, attenuated rubella vector to express vaccine antigens |
US20150224181A1 (en) | 2012-09-14 | 2015-08-13 | The United States Of America As Represented By The Secretary Department Of Health And Human Se | Brachyury protein, non-poxvirus non-yeast vectors encoding brachyury protein, and their use |
CA2881559C (en) | 2012-09-24 | 2020-08-04 | Ventana Medical Systems, Inc. | Method of identifying treatment responsive non-small cell lung cancer using anaplastic lymphoma kinase (alk) as a marker |
US9221908B2 (en) | 2012-12-12 | 2015-12-29 | Vasculox, Inc. | Therapeutic CD47 antibodies |
SG11201504469XA (en) | 2012-12-12 | 2015-07-30 | Vasculox Inc | Therapeutic cd47 antibodies |
ES2639559T3 (es) | 2012-12-28 | 2017-10-27 | Ventana Medical Systems, Inc. | Análisis de imágenes para el pronóstico de cáncer de mama |
WO2014164472A1 (en) | 2013-03-10 | 2014-10-09 | The Board Of Regents Of The University Of Texas System | Biomarkers for chagas disease related cardiomyopathy |
WO2015070014A1 (en) | 2013-11-08 | 2015-05-14 | Biogen Idec Ma Inc. | Procoagulant fusion compound |
WO2015199976A1 (en) | 2014-06-24 | 2015-12-30 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Target activated microdissection |
AU2015300915B2 (en) | 2014-08-08 | 2020-09-24 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Photo-controlled removal of targets in vitro and in vivo |
EP4183806A3 (de) * | 2014-11-12 | 2023-08-02 | Seagen Inc. | Glycaninteragierende verbindungen und verfahren zur verwendung |
CN116425875A (zh) | 2015-09-18 | 2023-07-14 | 安驰肿瘤公司 | 治疗性cd47抗体 |
US11014088B2 (en) | 2016-03-09 | 2021-05-25 | The Board Of Regents Of The University Of Texas System | Sensitive ELISA for disease diagnosis on surface modified poly(methyl methacrylate) (PMMA) microfluidic microplates |
EP3529276A4 (de) | 2016-10-21 | 2020-06-17 | Arch Oncology, Inc. | Therapeutische cd47-antikörper |
US20200209241A1 (en) | 2017-09-15 | 2020-07-02 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods of classifying response to immunotherapy for cancer |
AU2018347796A1 (en) | 2017-10-10 | 2020-05-07 | Medicenna Therapeutics, Inc. | IL-4-fusion formulations for treatment of central nervous system (CNS) tumors |
EP4038222A4 (de) | 2019-10-02 | 2023-10-18 | Arizona Board of Regents on behalf of Arizona State University | Verfahren und zusammensetzungen zur identifizierung von neoantigenen zur verwendung bei der behandlung und vorbeugung von krebs |
WO2024044687A1 (en) | 2022-08-26 | 2024-02-29 | Valo Health, Inc. | Biomarker combinations for prognosis and management of diabetic retinopathy |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6147500A (ja) * | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
GB8422238D0 (en) * | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
JPS61134325A (ja) * | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
EP0247091B1 (de) * | 1985-11-01 | 1993-09-29 | Xoma Corporation | Modulare einheit von antikörpergenen, daraus hergestellte antikörper und verwendung |
-
1987
- 1987-07-07 EP EP87306006A patent/EP0256654B1/de not_active Expired - Lifetime
- 1987-07-07 CA CA000541501A patent/CA1340456C/en not_active Expired - Lifetime
- 1987-07-07 DE DE3751908T patent/DE3751908T2/de not_active Expired - Lifetime
- 1987-07-07 AT AT87306006T patent/ATE143052T1/de not_active IP Right Cessation
-
1997
- 1997-07-22 JP JP9228781A patent/JPH1070991A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP0256654A2 (de) | 1988-02-24 |
JPH1070991A (ja) | 1998-03-17 |
EP0256654A3 (de) | 1989-06-07 |
DE3751908D1 (de) | 1996-10-24 |
CA1340456C (en) | 1999-03-23 |
EP0256654B1 (de) | 1996-09-18 |
ATE143052T1 (de) | 1996-10-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |