DE3685275D1 - Herstellung von 5-fluor-2'-deoxyuridin estern zur intravenoesen verabreichung. - Google Patents
Herstellung von 5-fluor-2'-deoxyuridin estern zur intravenoesen verabreichung.Info
- Publication number
- DE3685275D1 DE3685275D1 DE8686901491T DE3685275T DE3685275D1 DE 3685275 D1 DE3685275 D1 DE 3685275D1 DE 8686901491 T DE8686901491 T DE 8686901491T DE 3685275 T DE3685275 T DE 3685275T DE 3685275 D1 DE3685275 D1 DE 3685275D1
- Authority
- DE
- Germany
- Prior art keywords
- deoxyuridine
- fluor
- esters
- preparation
- intravenous administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- ODKNJVUHOIMIIZ-RRKCRQDMSA-N floxuridine Chemical class C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(F)=C1 ODKNJVUHOIMIIZ-RRKCRQDMSA-N 0.000 title 1
- 238000001990 intravenous administration Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP60028431A JPS61189215A (ja) | 1985-02-18 | 1985-02-18 | 5−フルオロ−2′−デオキシウリジンエステル類の油状医薬組成物 |
PCT/JP1986/000071 WO1986004816A1 (en) | 1985-02-18 | 1986-02-17 | Preparation of 5-fluoro-2'-deoxyuridine esters for intraarterial administration |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3685275D1 true DE3685275D1 (de) | 1992-06-17 |
Family
ID=12248470
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8686901491T Expired - Lifetime DE3685275D1 (de) | 1985-02-18 | 1986-02-17 | Herstellung von 5-fluor-2'-deoxyuridin estern zur intravenoesen verabreichung. |
Country Status (5)
Country | Link |
---|---|
US (1) | US4943564A (de) |
EP (1) | EP0214299B1 (de) |
JP (1) | JPS61189215A (de) |
DE (1) | DE3685275D1 (de) |
WO (1) | WO1986004816A1 (de) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2575372B2 (ja) * | 1987-02-12 | 1997-01-22 | 三井東圧化学株式会社 | 制ガン剤 |
JPH0794377B2 (ja) * | 1987-07-22 | 1995-10-11 | 呉羽化学工業株式会社 | エストラジオール誘導体を含有する注射剤 |
USRE38416E1 (en) | 1988-09-28 | 2004-02-03 | Epoch Biosciences, Inc. | Cross-linking oligonucleotides |
US5849482A (en) * | 1988-09-28 | 1998-12-15 | Epoch Pharmaceuticals, Inc. | Crosslinking oligonucleotides |
US5824796A (en) * | 1988-09-28 | 1998-10-20 | Epoch Pharmaceuticals, Inc. | Cross-linking oligonucleotides |
EP0472648A4 (en) * | 1989-05-18 | 1992-09-16 | Microprobe Corporation | Crosslinking oligonucleotides |
US6136601A (en) * | 1991-08-21 | 2000-10-24 | Epoch Pharmaceuticals, Inc. | Targeted mutagenesis in living cells using modified oligonucleotides |
WO1993018795A1 (en) * | 1992-03-19 | 1993-09-30 | Daikin Industries, Ltd. | Mri contrast medium and diagnostic method |
ATE272392T1 (de) * | 1999-02-08 | 2004-08-15 | Alza Corp | Verfahren zur kontrolle der liposomengrösse |
US8563592B2 (en) | 2001-11-01 | 2013-10-22 | Spectrum Pharmaceuticals, Inc. | Bladder cancer treatment and methods |
CA2466148C (en) | 2001-11-01 | 2013-01-08 | Spectrum Pharmaceuticals, Inc. | Medical compositions for intravesical treatment of bladder cancer |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3397268A (en) * | 1965-09-01 | 1968-08-13 | Upjohn Co | Process of treating herpes simplex with 1-beta-d-arabinofuranosylcytosine |
JPS6053005B2 (ja) * | 1976-12-22 | 1985-11-22 | 株式会社オカダライフコ−ポレイション | 制ガン油性製剤 |
JPS54122719A (en) * | 1978-03-16 | 1979-09-22 | Sankyo Co Ltd | Carcinostatic agent for oral administration |
JPS5550023A (en) * | 1978-10-04 | 1980-04-11 | Diafoil Co Ltd | Preparation of polyester |
US4490336A (en) * | 1981-05-27 | 1984-12-25 | Prodeco, Inc. | Process for stripping uranium from an alkyl pyrophosphoric acid |
JPS5849315A (ja) * | 1981-09-18 | 1983-03-23 | Mitsui Pharmaceut Inc | 抗腫瘍剤 |
DE3263939D1 (en) * | 1981-12-09 | 1985-07-04 | Teijin Ltd | 5-fluoro-2'-deoxyuridine derivatives and a process for the preparation thereof |
JPS58124714A (ja) * | 1982-01-20 | 1983-07-25 | Yamanouchi Pharmaceut Co Ltd | 抗腫瘍物質の油性組成物 |
JPS5913717A (ja) * | 1982-07-16 | 1984-01-24 | Asahi Chem Ind Co Ltd | エマルジヨン製剤 |
JPS5993096A (ja) * | 1982-11-19 | 1984-05-29 | Teijin Ltd | 5−フルオロ−2′−デオキシウリジン誘導体及びその製造法 |
JPS6028916A (ja) * | 1983-07-13 | 1985-02-14 | Yamanouchi Pharmaceut Co Ltd | アクラルビシンまたはその塩酸塩の油性組成物 |
JPS6023398A (ja) * | 1983-07-20 | 1985-02-05 | Teijin Ltd | 5−フルオロ−2′−デオキシウリジン誘導体その製造法およびそれを有効成分とする抗腫瘍剤 |
WO1985000608A1 (en) * | 1983-07-20 | 1985-02-14 | Teijin Limited | Antineoplastic agent |
US4684631A (en) * | 1984-10-09 | 1987-08-04 | Toyama Chemical Co., Ltd. | Novel 5-fluoro-2-deoxyuridine derivatives and salts thereof, process for producing the same, and antitumor agents containing the same |
JPH0623398A (ja) * | 1992-07-07 | 1994-02-01 | Hitachi Plant Eng & Constr Co Ltd | 汚泥の消化方法 |
-
1985
- 1985-02-18 JP JP60028431A patent/JPS61189215A/ja active Granted
-
1986
- 1986-02-17 DE DE8686901491T patent/DE3685275D1/de not_active Expired - Lifetime
- 1986-02-17 EP EP86901491A patent/EP0214299B1/de not_active Expired - Lifetime
- 1986-02-17 US US06/928,226 patent/US4943564A/en not_active Expired - Fee Related
- 1986-02-17 WO PCT/JP1986/000071 patent/WO1986004816A1/ja active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
JPS61189215A (ja) | 1986-08-22 |
JPH0434964B2 (de) | 1992-06-09 |
EP0214299A4 (de) | 1988-08-23 |
EP0214299A1 (de) | 1987-03-18 |
WO1986004816A1 (en) | 1986-08-28 |
EP0214299B1 (de) | 1992-05-13 |
US4943564A (en) | 1990-07-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |