DE3679920D1 - Spiro-3-heteroazolidinverbindungen und ihre salze, ihre herstellung und diese enthaltende pharmazeutische mittel. - Google Patents

Spiro-3-heteroazolidinverbindungen und ihre salze, ihre herstellung und diese enthaltende pharmazeutische mittel.

Info

Publication number
DE3679920D1
DE3679920D1 DE8686301530T DE3679920T DE3679920D1 DE 3679920 D1 DE3679920 D1 DE 3679920D1 DE 8686301530 T DE8686301530 T DE 8686301530T DE 3679920 T DE3679920 T DE 3679920T DE 3679920 D1 DE3679920 D1 DE 3679920D1
Authority
DE
Germany
Prior art keywords
heteroazolidine
spiro
salts
compounds
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8686301530T
Other languages
English (en)
Inventor
Masayasu Kurono
Takuji Yamaguchi
Toshinao Usui
Masato Fukushima
Kuniharu Mizuno
Akira Matsubara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanwa Kagaku Kenkyusho Co Ltd
Original Assignee
Sanwa Kagaku Kenkyusho Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanwa Kagaku Kenkyusho Co Ltd filed Critical Sanwa Kagaku Kenkyusho Co Ltd
Application granted granted Critical
Publication of DE3679920D1 publication Critical patent/DE3679920D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE8686301530T 1985-03-04 1986-03-04 Spiro-3-heteroazolidinverbindungen und ihre salze, ihre herstellung und diese enthaltende pharmazeutische mittel. Expired - Lifetime DE3679920D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP60041234A JPS61200991A (ja) 1985-03-04 1985-03-04 スピロ―３―ヘテロアゾリジン化合物、その製法及びそれを有効成分とする糖尿病合併症の予防及び治療剤

Publications (1)

Publication Number Publication Date
DE3679920D1 true DE3679920D1 (de) 1991-08-01

Family

ID=12602722

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686301530T Expired - Lifetime DE3679920D1 (de) 1985-03-04 1986-03-04 Spiro-3-heteroazolidinverbindungen und ihre salze, ihre herstellung und diese enthaltende pharmazeutische mittel.

Country Status (4)

Country Link
US (1) US4740517A (de)
EP (1) EP0193415B1 (de)
JP (1) JPS61200991A (de)
DE (1) DE3679920D1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3769066D1 (de) * 1986-08-28 1991-05-08 Sanwa Kagaku Kenkyusho Co Hydantoin-derivate zur behandlung von komplikationen bei diabetes.
JPS6357588A (ja) * 1986-08-28 1988-03-12 Sanwa Kagaku Kenkyusho Co Ltd ヒダントイン誘導体、その塩並びに該化合物を有効成分とする糖尿病合併症の予防及び治療剤
US4985573A (en) * 1986-08-28 1991-01-15 Sanwa Kagaku Kenkyusho Co., Ltd. Hydantoin derivatives for treating complications of diabetes
JPH0816107B2 (ja) * 1987-04-08 1996-02-21 株式会社三和化学研究所 （＋）―３，４―ジヒドロ―４―オキソ―２ｈ―１―ベンゾピラン―２―カルボン酸誘導体及びその製法
JPS63126881A (ja) * 1986-11-14 1988-05-30 Sanwa Kagaku Kenkyusho Co Ltd ヒダントイン誘導体、その塩、これらの製法並びに該化合物を有効成分とする糖尿病合併症の予防及び治療剤
JP2641879B2 (ja) * 1987-08-27 1997-08-20 株式会社 三和化学研究所 光学活性を有するヒダントイン誘導体の製法
JP2708507B2 (ja) * 1988-04-07 1998-02-04 株式会社三和化学研究所 （ｄ）‐６‐フルオロ‐２，３‐ジヒドロ‐２’，５’‐ジオキソ‐スピロ［４Ｈ‐１‐ベンゾピラン‐４，４’‐イミダゾリジン］‐２‐カルボキサミド誘導体、これらの製法及び用途
JP2688266B2 (ja) * 1989-02-22 1997-12-08 株式会社三和化学研究所 アルドース還元酵素阻害作用を有し且つ吸収性の良好な薬剤組成物
DE69004290T2 (de) * 1989-02-22 1994-05-26 Sanwa Kagaku Kenkyusho Co Pharmazeutische Zusammensetzung, die ein Hydantoin-Derivat enthält.
JPH0699308B2 (ja) * 1990-04-27 1994-12-07 株式会社三和化学研究所 ヒダントイン誘導体を有効成分とする循環器系疾患の予防及び治療剤並びに循環器系疾患と糖尿病合併症の同時的予防及び治療剤
US5164391A (en) * 1989-09-20 1992-11-17 Sanwa Kagaku Kenkyusho Co., Ltd. Hydantoin derivatives for treating complications of diabetes and circulatory diseases
JP2997894B2 (ja) * 1990-11-07 2000-01-11 株式会社三和化学研究所 循環器系疾患の予防及び治療剤
JP3049284B2 (ja) * 1990-11-07 2000-06-05 株式会社三和化学研究所 ヒダントイン誘導体並びにそれを有効成分とする糖尿病合併症及び循環器系疾患の予防及び治療剤
CA2113818A1 (en) * 1991-08-28 1993-03-18 Robert C. Gadwood Spirocyclic benzopyran imidazolines
JP4273406B2 (ja) * 2001-06-01 2009-06-03 小野薬品工業株式会社 アルドース還元酵素阻害剤を有効成分とする脱髄性疾患または脱髄を伴う疾患治療剤
US20060058310A1 (en) * 2002-11-14 2006-03-16 Yoshifumi Takenobu Remedies for vertebral canal stenosis
CN100537574C (zh) 2004-01-30 2009-09-09 株式会社三和化学研究所 糖尿病黄斑症的预防或治疗剂
US20070299119A1 (en) * 2004-02-20 2007-12-27 Sanwa Kagaku Kenkyusho Co., Ltd. Prophylactic or Therapeutic Agent for Severe Diabetic Retinopathy
US20080096923A1 (en) * 2004-07-23 2008-04-24 Aniz Girach Methods For Diagnosing And Treating Diabetic Microvascular Complications
ES2393271T3 (es) 2005-12-16 2012-12-19 Sanwa Kagaku Kenkyusho Co., Ltd Agente para la prevención y tratamiento de la insuficiencia renal aguda
EP1987829A4 (de) * 2006-02-20 2009-07-29 Sanwa Kagaku Kenkyusho Co Prophylaktikum bzw. therapeutikum für zerbrale ischämie oder eines durch zerebrale ischämie bedingten reperfusionsschadens bei apoplexie
DK2110141T3 (da) 2007-01-31 2013-06-17 Sanwa Kagaku Kenkyusho Co Middel til beskyttelse af retinalnerve eller synsnerve
WO2011072064A1 (en) * 2009-12-08 2011-06-16 Array Biopharma Inc. S piro [chroman - 4, 4 ' - imidazol] ones as beta - secretase inhibitors
RU2012134639A (ru) 2010-01-14 2014-02-20 Санва Кагаку Кенкюсо Ко., Лтд. Фармацевтический препарат для предупреждения и лечения нарушений, сопровождающихся глазным ангиогенезом и/или повышенной проницаемостью сосудов глаза
CA2791360A1 (en) * 2010-04-28 2011-11-03 Sanwa Kagaku Kenkyusho Co., Ltd. A pharmaceutical for preventing or treating an inner ear disorder

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB807678A (en) * 1956-01-16 1959-01-21 Harold Crowther Brimelow New substituted hydantoins and thiohydantoins
DE1940709A1 (de) * 1969-04-11 1970-11-05 Bitterfeld Chemie Fungizide Mittel
CA1088945A (en) * 1976-10-18 1980-11-04 Pfizer Limited Hydantoin derivatives as therapeutic agents
US4130714A (en) * 1977-05-23 1978-12-19 Pfizer Inc. Hydantoin therapeutic agents
US4200642A (en) * 1978-08-21 1980-04-29 Pfizer Inc. Spiro-oxazolidindiones
US4283409A (en) * 1979-10-29 1981-08-11 Pfizer Inc. Imidazolone derivatives
JPS5745185A (en) * 1980-07-21 1982-03-13 Eisai Co Ltd Hydantoin derivative and its preparation
JPS58213717A (ja) * 1982-01-20 1983-12-12 Eisai Co Ltd ヒダントイン誘導体を含有する治療用薬剤
US4464385A (en) * 1982-04-15 1984-08-07 Alcon Laboratories, Inc. Treatment of diabetic complications with hydantoins
DK277484A (da) * 1983-06-23 1984-12-24 Hoffmann La Roche Thiazolidinderivater
ZA844557B (en) * 1983-06-23 1985-02-27 Hoffmann La Roche Novel thiazolidine derivatives

Also Published As

Publication number Publication date
US4740517A (en) 1988-04-26
EP0193415A2 (de) 1986-09-03
EP0193415B1 (de) 1991-06-26
EP0193415A3 (en) 1987-09-02
JPH0372226B2 (de) 1991-11-18
JPS61200991A (ja) 1986-09-05

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: LINDNER BLAUMEIER & KOLLEGEN PATENT- UND RECHTSANW