DE3674569D1 - 2-((3,5-dihalo-4-aminobenzyl))imidazole. - Google Patents
2-((3,5-dihalo-4-aminobenzyl))imidazole.Info
- Publication number
- DE3674569D1 DE3674569D1 DE8686115057T DE3674569T DE3674569D1 DE 3674569 D1 DE3674569 D1 DE 3674569D1 DE 8686115057 T DE8686115057 T DE 8686115057T DE 3674569 T DE3674569 T DE 3674569T DE 3674569 D1 DE3674569 D1 DE 3674569D1
- Authority
- DE
- Germany
- Prior art keywords
- aminobenzyl
- dihalo
- imidazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/24—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/807,921 US4665095A (en) | 1985-12-11 | 1985-12-11 | Use of 2-[(3,5-dihalo-4-aminobenzyl)]imidazolines to stimulate alpha-1 adrenergic receptors and to treat nasal congestion |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3674569D1 true DE3674569D1 (de) | 1990-10-31 |
Family
ID=25197433
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8686115057T Expired - Fee Related DE3674569D1 (de) | 1985-12-11 | 1986-10-30 | 2-((3,5-dihalo-4-aminobenzyl))imidazole. |
Country Status (9)
Country | Link |
---|---|
US (1) | US4665095A (de) |
EP (1) | EP0230532B1 (de) |
JP (1) | JPH07116038B2 (de) |
AU (1) | AU591740B2 (de) |
CA (1) | CA1282334C (de) |
DE (1) | DE3674569D1 (de) |
FI (1) | FI865025A (de) |
NO (1) | NO864993L (de) |
NZ (1) | NZ218334A (de) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4970240A (en) * | 1989-10-18 | 1990-11-13 | Schering Corporation | Fruity flavored nasal decongestant composition |
US5114979A (en) * | 1989-10-18 | 1992-05-19 | Schering Corporation | Fruity flavored nasal decongestant composition |
JP4096363B2 (ja) * | 1997-03-14 | 2008-06-04 | 日本新薬株式会社 | 鼻又は眼の充血治療剤 |
SG72827A1 (en) * | 1997-06-23 | 2000-05-23 | Hoffmann La Roche | Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives |
WO1999057131A1 (en) * | 1998-05-06 | 1999-11-11 | Duke University | Method of treating bladder and lower urinary tract syndromes |
JP2009524617A (ja) * | 2006-01-27 | 2009-07-02 | エフ.ホフマン−ラ ロシュ アーゲー | 置換2−イミダゾール又はイミダゾリン誘導体の使用 |
KR101172940B1 (ko) * | 2006-10-19 | 2012-08-10 | 에프. 호프만-라 로슈 아게 | 트레이스 아민 관련 수용체에 대해 친화도를 갖는 아미노메틸-2-이미다졸 |
KR101176699B1 (ko) * | 2006-10-19 | 2012-08-23 | 에프. 호프만-라 로슈 아게 | 아미노메틸-4-이미다졸 |
ATE533755T1 (de) * | 2006-11-02 | 2011-12-15 | Hoffmann La Roche | Substituierte 2-imidazole als modulatoren der mit spurenaminen assoziierten rezeptoren |
RU2456281C2 (ru) * | 2006-11-16 | 2012-07-20 | Ф. Хоффманн-Ля Рош Аг | Замещенные 4-имидазолы, способ их получения и их применение |
BRPI0720047A2 (pt) * | 2006-12-13 | 2013-12-24 | Hoffmann La Roche | 2-imidazóis como ligantes para receptores associados a aminas de traço (taar) |
US20080146523A1 (en) * | 2006-12-18 | 2008-06-19 | Guido Galley | Imidazole derivatives |
CA2675221C (en) * | 2007-02-02 | 2016-02-23 | F. Hoffmann-La Roche Ag | Novel 2-aminooxazolines as taar1 ligands |
KR101222412B1 (ko) * | 2007-02-15 | 2013-01-15 | 에프. 호프만-라 로슈 아게 | Taar1 리간드로서의 2-아미노옥사졸린 |
WO2009003868A2 (en) | 2007-07-02 | 2009-01-08 | F. Hoffmann-La Roche Ag | 2 -imidazolines having a good affinity to the trace amine associated receptors (taars) |
CA2691704A1 (en) * | 2007-07-03 | 2009-01-08 | F. Hoffmann-La Roche Ag | 4-imidazolines and their use as antidepressants |
BRPI0813837A2 (pt) * | 2007-07-27 | 2015-01-06 | Hoffmann La Roche | 2-azetidinametanoaminas e 2-pirrolidinametanoaminas como ligantes de taar |
WO2009016088A1 (en) * | 2007-08-02 | 2009-02-05 | F. Hoffmann-La Roche Ag | The use of benzamide derivatives for the treatment of cns disorders |
JP5341084B2 (ja) * | 2007-08-03 | 2013-11-13 | エフ.ホフマン−ラ ロシュ アーゲー | Taar1リガンドとしてのピリジンカルボキシアミド及びベンズアミド誘導体 |
DK2207537T3 (en) * | 2007-10-02 | 2017-10-02 | Fremont Group Ltd | Systemic pro-haemostatic effect of sympathomimetics with agonistic effects on alpha-adrenergic and / or beta-adrenergic receptors in the sympathetic nervous system, related to improved clot strength |
US8242153B2 (en) * | 2008-07-24 | 2012-08-14 | Hoffmann-La Roche Inc. | 4,5-dihydro-oxazol-2YL derivatives |
RU2513086C2 (ru) * | 2008-07-24 | 2014-04-20 | Ф.Хоффманн-Ля Рош Аг | Производные 4,5-дигидро-оксазол-2-ила |
US20100311798A1 (en) * | 2009-06-05 | 2010-12-09 | Decoret Guillaume | 2-aminooxazolines as taar1 ligands |
US8354441B2 (en) * | 2009-11-11 | 2013-01-15 | Hoffmann-La Roche Inc. | Oxazoline derivatives |
US9452980B2 (en) | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
AU2017234042B2 (en) | 2016-03-17 | 2020-11-19 | F. Hoffmann-La Roche Ag | 5-ethyl-4-methyl-pyrazole-3-carboxamide derivative having activity as agonist of TAAR |
AU2018280236B2 (en) | 2017-06-07 | 2024-06-06 | Shifamed Holdings, Llc | Intravascular fluid movement devices, systems, and methods of use |
US11511103B2 (en) | 2017-11-13 | 2022-11-29 | Shifamed Holdings, Llc | Intravascular fluid movement devices, systems, and methods of use |
CN112004563A (zh) | 2018-02-01 | 2020-11-27 | 施菲姆德控股有限责任公司 | 血管内血泵以及使用和制造方法 |
US11964145B2 (en) | 2019-07-12 | 2024-04-23 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of manufacture and use |
WO2021016372A1 (en) | 2019-07-22 | 2021-01-28 | Shifamed Holdings, Llc | Intravascular blood pumps with struts and methods of use and manufacture |
US11724089B2 (en) | 2019-09-25 | 2023-08-15 | Shifamed Holdings, Llc | Intravascular blood pump systems and methods of use and control thereof |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2731471A (en) * | 1956-01-17 | Nxg hi | ||
US2868802A (en) * | 1959-01-13 | Nxchj | ||
DE1617618B2 (de) * | 1966-06-18 | 1976-05-20 | Merck Patent Gmbh, 6100 Darmstadt | Schleimhautabschwellende mittel zur lokalen applikation |
DE1618005A1 (de) * | 1966-09-22 | 1971-09-09 | Thomae Gmbh Dr K | Verfahren zur Herstellung von neuen Amino-dihalogen-phenyl-aethylaminen |
US3660423A (en) * | 1970-02-13 | 1972-05-02 | Dow Chemical Co | 2-(substituted benzyl)methyl-2-imidazolines |
US3922282A (en) * | 1975-01-17 | 1975-11-25 | American Home Prod | 2-Aryl-2-imidazoline-1-propionic acids and their esters |
AU1623483A (en) * | 1978-02-01 | 1983-10-13 | Wellcome Foundation Limited, The | Formulations of imidazole derivatives |
US4506074A (en) * | 1982-11-08 | 1985-03-19 | Merck & Co., Inc. | 2-[2-Pyridinyloxy(thio or amino)methyl]-1H-imidazoles and derivatives |
US4461914A (en) * | 1983-02-01 | 1984-07-24 | American Cyanamid Company | Method for the preparation of 1-(4'-amino-3',5'-dichlorophenyl)-2-alkyl(or dialkyl)aminoethanols |
FR2549049B1 (fr) * | 1983-07-13 | 1986-06-20 | Chauvin Blache Lab | Nouvelles amidines, leur procede de preparation et leur application therapeutique |
-
1985
- 1985-12-11 US US06/807,921 patent/US4665095A/en not_active Expired - Fee Related
-
1986
- 1986-10-30 DE DE8686115057T patent/DE3674569D1/de not_active Expired - Fee Related
- 1986-10-30 EP EP86115057A patent/EP0230532B1/de not_active Expired - Lifetime
- 1986-11-19 NZ NZ218334A patent/NZ218334A/xx unknown
- 1986-11-28 JP JP61282192A patent/JPH07116038B2/ja not_active Expired - Lifetime
- 1986-12-02 CA CA000524368A patent/CA1282334C/en not_active Expired - Fee Related
- 1986-12-09 AU AU66319/86A patent/AU591740B2/en not_active Ceased
- 1986-12-10 NO NO864993A patent/NO864993L/no unknown
- 1986-12-10 FI FI865025A patent/FI865025A/fi not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JPS62145067A (ja) | 1987-06-29 |
NO864993L (no) | 1987-06-12 |
JPH07116038B2 (ja) | 1995-12-13 |
FI865025A0 (fi) | 1986-12-10 |
NO864993D0 (no) | 1986-12-10 |
FI865025A (fi) | 1987-06-12 |
AU591740B2 (en) | 1989-12-14 |
AU6631986A (en) | 1987-06-18 |
US4665095A (en) | 1987-05-12 |
NZ218334A (en) | 1989-03-29 |
EP0230532B1 (de) | 1990-09-26 |
CA1282334C (en) | 1991-04-02 |
EP0230532A1 (de) | 1987-08-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |