DE3621844C2 - Injizierbare, Doxorubicin-enthaltende Lösung und Verfahren zur Herstellung derselben - Google Patents
Injizierbare, Doxorubicin-enthaltende Lösung und Verfahren zur Herstellung derselbenInfo
- Publication number
- DE3621844C2 DE3621844C2 DE3621844A DE3621844A DE3621844C2 DE 3621844 C2 DE3621844 C2 DE 3621844C2 DE 3621844 A DE3621844 A DE 3621844A DE 3621844 A DE3621844 A DE 3621844A DE 3621844 C2 DE3621844 C2 DE 3621844C2
- Authority
- DE
- Germany
- Prior art keywords
- acid
- solution
- doxorubicin
- vials
- physiologically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Revoked
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
Description
- - aliphatische Amide, z. B. N,N-Dimethylacetamid, N-Hydroxy-2-ethyl-lactamid,
- - Alkohole, z. B. Ethanol, Benzylalkohol,
- - Glykole und Polyalkohole, z. B. Propylenglykol, Glycerin,
- - Ester von Polyalkoholen, z. B. Diacetin, Triacetin,
- - Polyglycole oder Polyether, z. B. Polyethylenglykol 400, Propylenglykolmethelether,
- - Dioxolane, z. B. Isopropylenglycerin,
- - Dimethylisosorbid,
- - Pyrrolidonderivate, z. B. 2-Pyrrolidon, N-Methyl-2-pyrrolidon, Polyvinylpyrrolidon.
Flüssigchromatograph: | |
Varian Modell 5010 | |
Spektrophotometrischer Detektor: | Knauer Modell 8700 |
Integrierender Schreiber: | Varian Modell CDS 401 |
Injektionsventil: | Rheodyne Modell 7125, versehen mit einer 10 µl-Probenschlaufe |
Chromatographische Säule: | Waters µ-Bondapak C18 (Länge=300 mm; Innendurchmesser=3,9 mm; durchschnittliche Partikelgröße=10 µm) |
Säulentemperatur: | Umgebungstemperatur (ca. 22°C±2°C) |
Mobile Phase: | Wasser : Acetonitril (Volumenverhältnis 69 : 31), mit Phosphorsäure auf pH 2 eingestellt, filtriert (Glassinterfilter, 1 µm oder feinerporös) und entlüftet |
Strömungsgeschwindigkeit der mobilen Phase: | 1,5 ml/min. |
Analytische Wellenlänge: | 254±1 nm |
Empfindlichkeit des integrierenden Schreibers: | 512 |
Geschwindigkeit des Diagrammpapiers: | 1 cm/min |
Claims (8)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3645281A DE3645281C2 (de) | 1985-08-02 | 1986-06-30 | Injizierbare, 4-Desmethoxy-daunorubicin- oder Daunorubicin enthaltende Lösung und Verfahren zur Herstellung derselben |
DE3645269A DE3645269C2 (de) | 1985-08-02 | 1986-06-30 | Injizierbare, Epirubicin-enthaltende Lösung und Verfahren zur Herstellung derselben |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB858519452A GB8519452D0 (en) | 1985-08-02 | 1985-08-02 | Injectable solutions |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3621844A1 DE3621844A1 (de) | 1987-03-05 |
DE3621844C2 true DE3621844C2 (de) | 1994-02-17 |
Family
ID=10583216
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3621844A Revoked DE3621844C2 (de) | 1985-08-02 | 1986-06-30 | Injizierbare, Doxorubicin-enthaltende Lösung und Verfahren zur Herstellung derselben |
Country Status (34)
Country | Link |
---|---|
US (1) | US4946831A (de) |
JP (1) | JPH0655667B2 (de) |
KR (1) | KR920001773B1 (de) |
CN (1) | CN1064531C (de) |
AT (1) | AT397463B (de) |
BE (1) | BE905202A (de) |
BG (1) | BG60425B2 (de) |
CA (1) | CA1291037C (de) |
CH (2) | CH668911C1 (de) |
CS (1) | CS277561B6 (de) |
CY (1) | CY1592A (de) |
DE (1) | DE3621844C2 (de) |
DK (1) | DK167557B1 (de) |
ES (1) | ES8801580A1 (de) |
FI (1) | FI86800C (de) |
FR (1) | FR2585569B1 (de) |
GB (2) | GB8519452D0 (de) |
GR (1) | GR861556B (de) |
HK (1) | HK93990A (de) |
HU (1) | HU196123B (de) |
IE (1) | IE59297B1 (de) |
IL (1) | IL79129A (de) |
IT (1) | IT1204906B (de) |
NL (2) | NL191507C (de) |
NO (1) | NO170913C (de) |
NZ (1) | NZ216604A (de) |
PH (1) | PH22332A (de) |
PT (1) | PT82865B (de) |
RU (2) | RU1837883C (de) |
SE (1) | SE466383C (de) |
SG (1) | SG80690G (de) |
UA (1) | UA29383C2 (de) |
YU (1) | YU44788B (de) |
ZA (1) | ZA864792B (de) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19544532A1 (de) * | 1995-11-29 | 1997-06-05 | Pharma Dynamics Gmbh | Doxorubicin-Lyophilisat |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5977082A (en) | 1985-08-02 | 1999-11-02 | Pharmacia & Upjohn Company | Injectable ready-to-use solutions containing an antitumor anthracycline glycoside |
US5124317A (en) * | 1985-08-02 | 1992-06-23 | Farmitalia Carlo Erba S.P.A. | Injectable ready-to-use solutions containing an antitumor anthracycline glycoside |
US5124318A (en) * | 1985-08-02 | 1992-06-23 | Farmitalia Carlo Erba S.R.L. | Injectable ready-to-use solutions containing an antitumor anthracycline glycoside |
EP0438183B1 (de) * | 1986-12-05 | 1995-11-08 | PHARMACIA S.p.A. | Anthracyclin-Glucosid enthaltende einspritzbare gebrauchsfertige Lösungen gegen Krebs |
FI883338A (fi) * | 1987-07-16 | 1989-01-17 | Bristol Myers Co | Vattenloesningar av doxorubicinhydroklorid. |
FI883337A (fi) * | 1987-07-16 | 1989-01-17 | Bristol Myers Co | Icke-vattenloesningar av doxorubicinhydroklorin. |
DE3801178A1 (de) * | 1988-01-18 | 1989-07-27 | Hoechst Ag | Stabilisierte trockenzubereitung zytostatisch wirksamer anthracyclin-antibiotika und verfahren zu ihrer herstellung |
JPH02200636A (ja) * | 1988-12-05 | 1990-08-08 | Bristol Myers Squibb Co | ドキソルビシン非水溶液 |
FI895733A0 (fi) * | 1988-12-05 | 1989-11-30 | Bristol Myers Squibb Co | Vattenloesningar av doxorubicin. |
GB9200247D0 (en) * | 1992-01-07 | 1992-02-26 | Erba Carlo Spa | Pharmaceutical compositions containing polymer derivative-bound anthracycline glycosides and a method for their preparation |
PT848009E (pt) * | 1996-12-16 | 2000-11-30 | Pharmachemie Bv | Processo para a preparacao de epirubicina ou seus sais de adicao de acido a partir de daunorubicina |
DE69737510T2 (de) | 1996-12-30 | 2007-12-06 | Battelle Memorial Institute, Columbus | Verwendung eines unverkapselten Antikrebs-Arzneimittels zur Herstellung einer Zubereitung zur Behandlung von Neoplasmen durch Inhalation |
US20090253220A1 (en) * | 2003-10-28 | 2009-10-08 | Sukanta Banerjee | Absorbing Biomolecules into Gel-Shell Beads |
JP2008513519A (ja) * | 2005-05-11 | 2008-05-01 | シコール インコーポレイティド | 安定した凍結乾燥されたアントラサイクリングリコシド |
WO2013063286A1 (en) * | 2011-10-25 | 2013-05-02 | Nektar Therapeutics | Treatment of patients suffering from cancer |
CN102614118B (zh) * | 2012-03-15 | 2014-04-30 | 北京协和药厂 | 注射用盐酸表柔比星制剂的制备方法及制剂 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
YU33730B (en) * | 1967-04-18 | 1978-02-28 | Farmaceutici Italia | Process for preparing a novel antibiotic substance and salts thereof |
GB1457632A (en) * | 1974-03-22 | 1976-12-08 | Farmaceutici Italia | Adriamycins |
GB1500421A (en) * | 1975-01-22 | 1978-02-08 | Farmaceutici Italia | Optically active anthracyclinones |
US4039663A (en) * | 1975-03-19 | 1977-08-02 | Societa' Farmaceutici Italia S.P.A. | Daunomycins, process for their uses and intermediates |
FR2314726A1 (fr) * | 1975-06-16 | 1977-01-14 | Rhone Poulenc Ind | Nouveaux derives du naphtagene, leur preparation et les compositions qui les contiennent |
GB1511559A (en) * | 1975-09-26 | 1978-05-24 | Farmaceutici Italia | Anthracycline glycosides |
FR2397425A1 (fr) * | 1977-07-11 | 1979-02-09 | Rhone Poulenc Ind | Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent |
DE2738656A1 (de) * | 1977-08-26 | 1979-03-08 | Microbial Chem Res Found | Anthracyclinglycoside, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
GB2007645B (en) * | 1977-10-17 | 1982-05-12 | Stanford Res Inst Int | Benzyl anthracyclines and pharmaceutical compositions containing them |
US4177264A (en) * | 1977-10-17 | 1979-12-04 | Sri International | N-benzyl anthracyclines |
FR2430425A1 (fr) * | 1978-07-07 | 1980-02-01 | Rhone Poulenc Ind | Nouveaux derives de la daunorubicine, leur preparation et les compositions pharmaceutiques qui les contiennent |
FR2433027A1 (fr) * | 1978-08-08 | 1980-03-07 | Rhone Poulenc Ind | Nouveau procede de preparation de derives de la doxorubicine |
US4325947A (en) * | 1981-05-12 | 1982-04-20 | Farmitalia Carlo Erba S.P.A. | 4-Demethoxy-4'-deoxydoxorubicin |
US4438105A (en) * | 1982-04-19 | 1984-03-20 | Farmaitalia Carlo Erba S.P.A | 4'-Iododerivatives of anthracycline glycosides |
US4464529A (en) * | 1982-07-20 | 1984-08-07 | Sri International | Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin |
JPS6092212A (ja) * | 1983-10-26 | 1985-05-23 | Kyowa Hakko Kogyo Co Ltd | ドキソルビシン塩の製剤 |
EP0438183B1 (de) * | 1986-12-05 | 1995-11-08 | PHARMACIA S.p.A. | Anthracyclin-Glucosid enthaltende einspritzbare gebrauchsfertige Lösungen gegen Krebs |
-
1985
- 1985-08-02 GB GB858519452A patent/GB8519452D0/en active Pending
-
1986
- 1986-06-16 YU YU1035/86A patent/YU44788B/xx unknown
- 1986-06-16 GR GR861556A patent/GR861556B/el unknown
- 1986-06-17 IL IL79129A patent/IL79129A/xx not_active IP Right Cessation
- 1986-06-17 IE IE159886A patent/IE59297B1/en not_active IP Right Cessation
- 1986-06-18 GB GB8614800A patent/GB2178311B/en not_active Expired
- 1986-06-19 SE SE8602743A patent/SE466383C/sv not_active IP Right Cessation
- 1986-06-19 FI FI862629A patent/FI86800C/fi not_active IP Right Cessation
- 1986-06-19 ES ES556291A patent/ES8801580A1/es not_active Expired
- 1986-06-20 NZ NZ216604A patent/NZ216604A/xx unknown
- 1986-06-20 FR FR868608964A patent/FR2585569B1/fr not_active Expired - Lifetime
- 1986-06-20 HU HU862614A patent/HU196123B/hu unknown
- 1986-06-24 CH CH2534/86A patent/CH668911C1/de not_active IP Right Cessation
- 1986-06-24 CH CH02158/99A patent/CH690490C2/de not_active IP Right Cessation
- 1986-06-25 CS CS864708A patent/CS277561B6/cs not_active IP Right Cessation
- 1986-06-26 IT IT20917/86A patent/IT1204906B/it active Protection Beyond IP Right Term
- 1986-06-26 NO NO19862587A patent/NO170913C/no not_active IP Right Cessation
- 1986-06-27 PT PT82865A patent/PT82865B/pt unknown
- 1986-06-27 CA CA000512613A patent/CA1291037C/en not_active Expired - Lifetime
- 1986-06-27 JP JP61149878A patent/JPH0655667B2/ja not_active Expired - Lifetime
- 1986-06-27 UA UA5011936A patent/UA29383C2/uk unknown
- 1986-06-27 RU SU864027713A patent/RU1837883C/ru active
- 1986-06-27 NL NL8601698A patent/NL191507C/nl not_active IP Right Cessation
- 1986-06-27 ZA ZA864792A patent/ZA864792B/xx unknown
- 1986-06-27 DK DK306286A patent/DK167557B1/da not_active IP Right Cessation
- 1986-06-28 CN CN86104283A patent/CN1064531C/zh not_active Expired - Lifetime
- 1986-06-28 KR KR1019860005231A patent/KR920001773B1/ko not_active IP Right Cessation
- 1986-06-30 AT AT0176886A patent/AT397463B/de active Protection Beyond IP Right Term
- 1986-06-30 PH PH33966A patent/PH22332A/en unknown
- 1986-06-30 DE DE3621844A patent/DE3621844C2/de not_active Revoked
- 1986-07-31 BE BE0/216997A patent/BE905202A/fr not_active IP Right Cessation
-
1989
- 1989-07-27 US US07/385,999 patent/US4946831A/en not_active Expired - Lifetime
-
1990
- 1990-10-04 SG SG806/90A patent/SG80690G/en unknown
- 1990-11-15 HK HK939/90A patent/HK93990A/xx not_active IP Right Cessation
-
1992
- 1992-04-03 CY CY1592A patent/CY1592A/xx unknown
- 1992-06-24 RU SU5011936A patent/RU2110263C1/ru active
-
1993
- 1993-12-21 BG BG98321A patent/BG60425B2/bg unknown
-
2000
- 2000-07-18 NL NL300011C patent/NL300011I1/nl unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19544532A1 (de) * | 1995-11-29 | 1997-06-05 | Pharma Dynamics Gmbh | Doxorubicin-Lyophilisat |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8127 | New person/name/address of the applicant |
Owner name: FARMITALIA CARLO ERBA S.R.L., MAILAND/MILANO, IT |
|
8128 | New person/name/address of the agent |
Representative=s name: EITLE, W., DIPL.-ING. HOFFMANN, K., DIPL.-ING. DR. |
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8110 | Request for examination paragraph 44 | ||
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D2 | Grant after examination | ||
8363 | Opposition against the patent | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: PHARMACIA S.P.A., MAILAND/MILANO, IT |
|
8325 | Change of the main classification |
Ipc: A61K 31/71 |
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