DE3580134D1 - Benzoesaeurederivate. - Google Patents

Benzoesaeurederivate.

Info

Publication number
DE3580134D1
DE3580134D1 DE8585108383T DE3580134T DE3580134D1 DE 3580134 D1 DE3580134 D1 DE 3580134D1 DE 8585108383 T DE8585108383 T DE 8585108383T DE 3580134 T DE3580134 T DE 3580134T DE 3580134 D1 DE3580134 D1 DE 3580134D1
Authority
DE
Germany
Prior art keywords
benzoesaeur
derivatives
benzoesaeur derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8585108383T
Other languages
English (en)
Inventor
Koichi Prof Dr Shudo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RESEARCH FOUNDATION ITSUU LABORATORY, TOKIO/TOKYO,
Original Assignee
SHUDO KOICHI PROF DR CHEM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP14119484A external-priority patent/JPS6122047A/ja
Priority claimed from JP19708984A external-priority patent/JPS6176440A/ja
Application filed by SHUDO KOICHI PROF DR CHEM filed Critical SHUDO KOICHI PROF DR CHEM
Application granted granted Critical
Publication of DE3580134D1 publication Critical patent/DE3580134D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
    • C07C65/38—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
    • C07C65/40—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D303/40—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by ester radicals
DE8585108383T 1984-07-07 1985-07-05 Benzoesaeurederivate. Expired - Fee Related DE3580134D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP14119484A JPS6122047A (ja) 1984-07-07 1984-07-07 安息香酸誘導体
JP19708984A JPS6176440A (ja) 1984-09-19 1984-09-19 安息香酸誘導体

Publications (1)

Publication Number Publication Date
DE3580134D1 true DE3580134D1 (de) 1990-11-22

Family

ID=26473481

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585108383T Expired - Fee Related DE3580134D1 (de) 1984-07-07 1985-07-05 Benzoesaeurederivate.

Country Status (3)

Country Link
US (1) US4703110A (de)
EP (1) EP0170105B1 (de)
DE (1) DE3580134D1 (de)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62215581A (ja) * 1986-03-18 1987-09-22 Koichi Shiyudo フラボンカルボン酸誘導体
WO1987007835A1 (en) * 1986-06-21 1987-12-30 Dainippon Ink And Chemicals, Inc. Drug for treatment and prophylaxis of kidney and liver diseases
US4808631A (en) * 1986-11-07 1989-02-28 Hoffmann-La Roche Inc. Aromatic acid derivatives
US5264578A (en) * 1987-03-20 1993-11-23 Allergan, Inc. Disubstituted acetylenes bearing heterobicyclic groups and heteroaromatic or phenyl groups having retinoid like activity
US4939156A (en) * 1987-07-11 1990-07-03 Meiji Seika Kaisha, Ltd. New tetramethyl-cis-diaza-bicyclo{4.2.0}octane-3,5-dione derivatives having differentiation-inducing activity and antiviral activity
LU87039A1 (fr) * 1987-11-04 1989-06-14 Oreal Esters biaromatiques d'antibiotiques macrolidiques et lincosamidiques,leur procede de preparation et compositions pharmaceutiques et cosmetiques les contenant
LU87037A1 (fr) * 1987-11-04 1989-06-14 Oreal Esters polyaromatiques d'antibiotiques macrolidiques et lincosamidiques,leur procede de preparation et compositions pharmaceutiques et cosmetiques les contenant
JP2752630B2 (ja) * 1988-03-29 1998-05-18 大鵬薬品工業株式会社 新規安息香酸誘導体及びその製造方法
AU618590B2 (en) * 1988-04-11 1992-01-02 Allergan, Inc. Tetralin esters of phenols or benzoic acids having retinoid like activity
DE3830054A1 (de) * 1988-09-03 1990-03-15 Boehringer Mannheim Gmbh Phenylamide - verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
DE3903989A1 (de) * 1989-02-10 1990-09-20 Basf Ag Diphenylheteroalkylderivate, ihre herstellung und daraus hergestellte arzneimittel und kosmetika
US5527945A (en) * 1989-02-10 1996-06-18 Basf Aktiengesellschaft Diphenylheteroalkyl derivatives, the preparation thereof and drugs and cosmetics prepared therefrom
IT1232252B (it) * 1989-02-22 1992-01-28 Rotta Research Lab Derivati della n fenil benzamide ad attivita' antiulcera ed antiallerica e procedimento per la loro preparazione
CA2020887A1 (en) * 1989-07-28 1991-01-29 Michael Klaus Aromatic carboxylic amides
US5183827A (en) * 1989-09-19 1993-02-02 Allergan, Inc. Acetylenes disubstituted with a heteroaromatic group and a 2-substituted chromanyl, thiochromanyl or 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity
US5272156A (en) * 1989-09-19 1993-12-21 Allergan, Inc. Acetylenes disubstituted with a heteroaromatic group and a 2-substituted 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity
US5264456A (en) * 1989-12-29 1993-11-23 Allergan, Inc. Acetylenes disubstituted with a furyl group and a substituted phenyl group having retinoid like activity
US5668175A (en) * 1991-08-23 1997-09-16 The Salk Institute For Biological Studies Use of selective ligands for treatment of disease states responsive to steroid or steroid-like retinoids
WO1993003713A1 (en) * 1991-08-23 1993-03-04 The Salk Institute For Biological Studies Use of selective ligands for treatment of disease states responsive to steroid or steroid-like hormones
EP0617020A1 (de) * 1992-04-02 1994-09-28 Shudo, Koichi, Prof. Dr. Carbonsäure mit retinsäure-ähnlicher Wirkung
US5324840A (en) * 1992-06-11 1994-06-28 Allergan, Inc. Method of treatment with compounds having retinoid-like activity and reduced skin toxicity and lacking teratogenic effects
US5455265A (en) 1993-02-11 1995-10-03 Allergan, Inc. Method of treatment with compounds having selective agonist-like activity on RXR retinoid receptors
US6172115B1 (en) 1993-02-11 2001-01-09 Allergan Sales, Inc. Method for preventing onset of restenosis after angioplasty employing an RXR-specific retinoid
EP0619116A3 (en) * 1993-04-05 1994-11-23 Hoechst Japan Use of synthetic retinoids for osteopathy.
US5475022A (en) * 1993-10-18 1995-12-12 Allergan, Inc. Phenyl or heteroaryl and tetrahydronaphthyl substituted diene compounds having retinoid like biological activity
FR2713635B1 (fr) * 1993-12-15 1996-01-05 Cird Galderma Nouveaux composés propynyl bi-aromatiques, compositions pharmaceutiques et cosmétiques les contenant et utilisations.
US5426118A (en) * 1993-12-30 1995-06-20 Allergan, Inc. [4-(1,2-epoxycyclohexanyl)but-3-en-1-ynyl]aromatic and heteroaromatic acids and derivatives having retinoid-like biological activity
US5648385A (en) * 1994-01-03 1997-07-15 Bristol-Myers Squibb Co. Retinoid-like compounds
NZ292121A (en) * 1994-08-10 1998-10-28 Hoffmann La Roche 5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene-2-yl derivatives and pharmaceutical compositions thereof
US5498755A (en) * 1994-08-23 1996-03-12 Chandraratna; Roshantha A. Disubstituted aryl and heteroaryl imines having retinoid-like biological activity
US6133326A (en) 1994-08-31 2000-10-17 Pfizer Inc Compositions and methods for decreasing sebum production
US5977125A (en) 1994-10-31 1999-11-02 Eisai Co., Ltd. Mono-or polyenic carboxylic acid derivatives
US5618931A (en) * 1994-12-29 1997-04-08 Allergan Acetylenes disubstituted with a 5 substituted dihydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity
US5489584A (en) * 1994-12-29 1996-02-06 Allergan, Inc. Acetylenes disubstituted with a 5-amino or substituted 5-amino substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity
US5556996A (en) * 1994-12-29 1996-09-17 Allergan Oxiranyls disubstituted with a phenyl group and a substituted chromanyl or tetrahydroquinolinyl group having retinoid like activity
US5543534A (en) * 1994-12-29 1996-08-06 Allergan Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl or heteroaryl groups having retinoid-like biological activity
US5599967A (en) * 1994-12-29 1997-02-04 Allergan Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl of heteroaryl group having retinoid-like biological activity
US5534641A (en) * 1994-12-29 1996-07-09 Allergan Acetylenes disubstituted with 2-tetrahydropyranoxyaryl and aryl or heteroaryl groups having retinoid-like biological activity
US5514825A (en) * 1994-12-29 1996-05-07 Allergan, Inc. Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity
US5618943A (en) * 1994-12-29 1997-04-08 Allergan Acetylenes disubstituted with a 5 OXO substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity
US5559248A (en) * 1995-04-05 1996-09-24 Bristol-Myers Squibb Co. Retinoid-like heterocycles
US6025388A (en) 1995-04-26 2000-02-15 Allergan Sales, Inc. Method for inhibiting gene expression promoted by AP1 protein with RARβ selective retinoids and method for treatment of diseases and conditions with such retinoids
US5616712A (en) * 1995-05-16 1997-04-01 Allergan Acetylenes disubstituted with a phenyl or heteroaryl group and a 2-thio-1,2,3,4-tetrahdroquinolinyl, 2-alkylthio-3,4-dihydroquinolinyl or 2-alkoxy-3,4-dihydroquinolinyl group having retinoid-like biological activity
US5675033A (en) * 1995-06-06 1997-10-07 Allergan 2,4-pentadienoic acid derivatives having retinoid-like biological activity
JP3964478B2 (ja) * 1995-06-30 2007-08-22 エーザイ・アール・アンド・ディー・マネジメント株式会社 ヘテロ環含有カルボン酸誘導体及びそれを含有する医薬
AU7598596A (en) * 1995-11-01 1997-05-22 Allergan, Inc. Sulfides, sulfoxides and sulfones disubstituted with a tetrahydronaphthalenyl, chromanyl, thiochromanyl or tetrahydroquinolinyl and substituted phenyl or heteroaryl group, having retinoid-like biological activity
US5726191A (en) * 1995-11-16 1998-03-10 Hoffmann-La Roche Inc. Aromatic carboxylic acid esters
US5663357A (en) * 1995-11-22 1997-09-02 Allergan Substituted heteroarylamides having retinoid-like biological activity
US5675024A (en) * 1995-11-22 1997-10-07 Allergan Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4,-tetrahydroquinoline carboxylic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity
US5688957A (en) * 1995-12-29 1997-11-18 Allergan (3"-thioxacyclohex-1"-enyl)!-but-3'-ene-1'-ynyl!aryl and (3"-thioxacyclohex-1"-enyl)!-but-3'-ene-1'-ynyl!heteroaryl carboxylic acids and esters having retinoid-like biological activity
US5965606A (en) * 1995-12-29 1999-10-12 Allergan Sales, Inc. Methods of treatment with compounds having RAR.sub.α receptor specific or selective activity
US5747542A (en) * 1996-06-21 1998-05-05 Allergan Oxo-substituted tetrahydronaphthalene derivatives having retinold and/or retinoid antagonist-like biological activity
US5741896A (en) * 1996-06-21 1998-04-21 Allergan O- or S- substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US5723666A (en) * 1996-06-21 1998-03-03 Allergan Oxime substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US5808124A (en) * 1996-06-21 1998-09-15 Allergan O- or S-substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US5763635A (en) * 1996-06-21 1998-06-09 Allergan Tetrahydronaphthalene derivatives substituted in the 8 position with alkyhidene groups having retinoid and/or retinoid antagonist-like biological activity
JPH10158192A (ja) 1996-10-03 1998-06-16 Eisai Co Ltd 移植片対宿主疾患（ｇｖｈｄ）の治療および臓器移植時の移植片拒絶反応抑制のための医薬組成物
US5739338A (en) * 1996-11-05 1998-04-14 Allergan N-aryl substituted tetrahydroquinolines having retinoid agonist, retinoid antagonist or retinoid inverse agonist type biological activity
US5728846A (en) * 1996-12-12 1998-03-17 Allergan Benzo 1,2-g!-chrom-3-ene and benzo 1,2-g!-thiochrom-3-ene derivatives
US5760276A (en) * 1997-03-06 1998-06-02 Allergan Aryl-and heteroarylcyclohexenyl substituted alkenes having retinoid agonist, antagonist or inverse agonist type biological activity
US6037488A (en) * 1997-04-19 2000-03-14 Allergan Sales, Inc. Trisubstituted phenyl derivatives having retinoid agonist, antagonist or inverse agonist type biological activity
US5919970A (en) * 1997-04-24 1999-07-06 Allergan Sales, Inc. Substituted diaryl or diheteroaryl methanes, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological activity
US6008251A (en) * 1998-03-27 1999-12-28 Bristol-Myers Squibb Company Retinoid-like compounds
FR2779720B1 (fr) * 1998-06-12 2002-08-16 Galderma Rech Dermatologique Nouveaux composes diarylselenures et leur utilisation en medecine humaine ou veterinaire ainsi qu'en cosmetologie
US7321050B2 (en) 1999-12-06 2008-01-22 Welichem Biotech Inc. Anti-inflammatory and psoriasis treatment and protein kinase inhibition by hydroxy stilbenes and novel stilbene derivatives and analogues
DE60043120D1 (de) * 1999-12-06 2009-11-19 Welichem Biotech Inc Polyhydroxystilbene und -stilbenoxide als antipsoriasismittel und proteinkinasehemmer
US6387951B1 (en) 2000-08-29 2002-05-14 Allergan Sales, Inc. Compounds having activity as inhibitors of cytochrome P450RAI
US6369261B1 (en) 2000-08-29 2002-04-09 Allergan Sales, Inc. Compounds having activity as inhibitors of cytochrome P450RAI
US6380256B1 (en) 2000-08-29 2002-04-30 Allergan Sales, Inc. Compounds having activity as inhibitors of cytochrome P450RAI
US6313107B1 (en) 2000-08-29 2001-11-06 Allergan Sales, Inc. Methods of providing and using compounds having activity as inhibitors of cytochrome P450RAI
AU8441601A (en) 2000-09-01 2002-03-13 Toko Pharmaceutical Ind Co Ltd Process for the production of crystals of a benzoic acid derivative
US20050202055A1 (en) * 2004-03-11 2005-09-15 Koichi Shudo, Tokyo, Japan Anti-wrinkle agent
JP5042839B2 (ja) * 2005-09-09 2012-10-03 有限会社ケムフィズ 腸疾患の予防及び／又は治療のための医薬
JP2008081427A (ja) * 2006-09-27 2008-04-10 R&R Inc 分泌障害性疾患の予防及び／又は治療のための医薬
CN101200435B (zh) * 2006-12-12 2011-12-07 江苏恒瑞医药股份有限公司 他米巴罗汀ⅱ型结晶的制备方法
US7902260B2 (en) * 2007-02-28 2011-03-08 Kemphys Ltd. Medicament for preventive and/or therapeutic treatment of lower urinary tract symptom
GB0915196D0 (en) 2009-09-01 2009-10-07 King S College London Therapeutic compounds and their use
CN103664680A (zh) * 2012-09-26 2014-03-26 山东鲁北药业有限公司 一种他米巴罗汀合成的新工艺
WO2016161107A1 (en) 2015-03-31 2016-10-06 Syros Pharmaceuticals, Inc. METHODS OF STRATIFYING PATIENTS FOR TREATMENT WITH RETINOIC ACID RECEPTOR-α AGONISTS
US9868994B2 (en) 2016-04-08 2018-01-16 Syros Pharmaceuticals, Inc. Methods of stratifying patients for treatment with retinoic acid receptor-α agonists
CN115737821B (zh) 2016-04-08 2024-04-12 赛罗斯制药有限公司 用于治疗aml和mds的rara激动剂
AU2018365241B2 (en) 2017-11-10 2023-09-14 Dermavant Sciences GmbH Process for preparing tapinarof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1565229A (en) * 1925-12-08 Georg kalischer
US3190876A (en) * 1962-04-19 1965-06-22 Nat Starch Chem Corp Ethylenically unsaturated azobenzene derivatives
FR2172868A1 (en) * 1972-02-24 1973-10-05 Fabre Sa Pierre Carboxy substd benzophenone derivs - as analgesics and antiinflammatory agents
US4190671A (en) * 1977-03-17 1980-02-26 Biorex Laboratories Limited Chalcone derivatives
DK159967C (da) * 1977-12-22 1991-06-03 Hoffmann La Roche Analogifremgangsmaade til fremstilling af terapeutisk aktive stilbenderivater
DE3118374A1 (de) * 1981-05-09 1982-11-25 Agfa-Gevaert Ag, 5090 Leverkusen Verfahren zur herstellung von sulfoalkylquartaersalzen
JPS5973555A (ja) * 1982-10-20 1984-04-25 Seiko Epson Corp エステル−アゾキシ化合物

Also Published As

Publication number Publication date
EP0170105A3 (en) 1986-03-26
US4703110A (en) 1987-10-27
EP0170105A2 (de) 1986-02-05
EP0170105B1 (de) 1990-10-17

Similar Documents

Publication Publication Date Title
DE3580134D1 (de) Benzoesaeurederivate.
DE3581051D1 (de) Substituierte azolylmethyl-cyclopropyl-carbinol-derivate.
DE3585671D1 (de) 5-amino-4-hydroxyvalerylamid-derivate.
DE3579625D1 (de) Aminoalkylphenoxyderivate.
DE3583455D1 (de) Salbenbase.
DE3581430D1 (de) Detergens.
DE3576268D1 (de) Hoergeraet.
ATE41922T1 (de) Alkylsulfonamidophenylalkylamine.
DE3585265D1 (de) Fibronektinpraeparate.
DE3587525T2 (de) Stepmotor.
DE3581707D1 (de) Neigungsmesser.
DE3583080D1 (de) Mikrorechner.
DE3578421D1 (de) Glycidyloxydiketone.
DE3582060D1 (de) Homopropargylamine.
ATE32711T1 (de) Fluorallylaminderivate.
FI73926B (fi) Standardhastighetsregulator foer motorfordon.
FI854403A (fi) Flerskivsraffinator uppvisande boejliga ekerorgan.
DE3583726D1 (de) 5-fluoruracilderivate.
DE3584628D1 (de) Xenocoumacine.
DE3577708D1 (de) Diphenylhexafluorpropanabkoemmlinge.
DE3586085D1 (de) Antitumor-4-hydroxy-2-zyklopentenonen.
DE3482590D1 (de) Carboxyalkyl-peptid-derivate.
FI852064A0 (fi) Cykloalkan-inden-karboxi -imidamidderivat.
DE3579862D1 (de) Mikrorechner.
FI855103A (fi) Hjulkapsel foer fordon.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: RESEARCH FOUNDATION ITSUU LABORATORY, TOKIO/TOKYO,

8339 Ceased/non-payment of the annual fee