FR2172868A1 - Carboxy substd benzophenone derivs - as analgesics and antiinflammatory agents - Google Patents

Carboxy substd benzophenone derivs - as analgesics and antiinflammatory agents

Info

Publication number
FR2172868A1
FR2172868A1 FR7206402A FR7206402A FR2172868A1 FR 2172868 A1 FR2172868 A1 FR 2172868A1 FR 7206402 A FR7206402 A FR 7206402A FR 7206402 A FR7206402 A FR 7206402A FR 2172868 A1 FR2172868 A1 FR 2172868A1
Authority
FR
France
Prior art keywords
acid
alkyl
substd
cmpds
dicarboxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7206402A
Other languages
French (fr)
Other versions
FR2172868B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre SA
Original Assignee
Pierre Fabre SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BE795722D priority Critical patent/BE795722A/en
Application filed by Pierre Fabre SA filed Critical Pierre Fabre SA
Priority to FR7206402A priority patent/FR2172868A1/en
Priority to DE19732308553 priority patent/DE2308553A1/en
Priority to CH268873A priority patent/CH563954A5/xx
Priority to ES411993A priority patent/ES411993A1/en
Priority to GB933773A priority patent/GB1420355A/en
Publication of FR2172868A1 publication Critical patent/FR2172868A1/en
Application granted granted Critical
Publication of FR2172868B1 publication Critical patent/FR2172868B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
    • C07C65/34—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
    • C07C65/40—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Abstract

Cmpds. (I) and their salts:- (where A is CH2, NH, a branched alkyl residue e.g. -CH(Me)-; a, b and c = 0,1 or 2, provided that if b=0, c=other than 0 and vice versa; R is H, alkyl or glyceryl; R1 and R2 are H, OH, alkyl, alkoxy, acyloxy or halogen; R3 and R4 are H, halogen, alkyl, CF3, alkoxy, carboxyl or CH2COOH and R5 is H, or alkyl). Antiinflammatory and analgesic agents. (A) Friedel Crafts reactions by splitting the anhydride e.g. homophthalic or by acylation of a benzene nucleus with a substd. phenylacetic acid chloride. (B) Condensation of an acid chloride with a homophthalic anhydride carbonion. (C) Intermolecular acylation e.g. 2 moles 4-methoxyphenyl acetic acid using polyphosphoric acid to remove water. (D) Gabriels reaction. (E) Esterification or salification of free acids. Of the 13 cmpds. the following are typical: 5-(alpha-phenyl-alpha-ethylacetyl)-orthocresotinic acid; 3,4-dimethylbenzoyl-orthotoluic acid; O-acetyl 5-phenacetyl orthorcresotinic acid; 2,2'-dicarboxy dibenzyl ketone; 2,2'-dicarboxy desoxybenzoin.
FR7206402A 1972-02-24 1972-02-24 Carboxy substd benzophenone derivs - as analgesics and antiinflammatory agents Granted FR2172868A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
BE795722D BE795722A (en) 1972-02-24 NEW DERIVATIVES WITH ANTI-INFLAMMATORY AND ANTALGIC ACTIVITY
FR7206402A FR2172868A1 (en) 1972-02-24 1972-02-24 Carboxy substd benzophenone derivs - as analgesics and antiinflammatory agents
DE19732308553 DE2308553A1 (en) 1972-02-24 1973-02-21 AROMATIC KETONE DERIVATIVES
CH268873A CH563954A5 (en) 1972-02-24 1973-02-23
ES411993A ES411993A1 (en) 1972-02-24 1973-02-23 Carboxy-containing diphenyl ketones and processes for preparing them
GB933773A GB1420355A (en) 1972-02-24 1973-02-26 Carboxy-containing diphenyl ketones and processes for preparing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7206402A FR2172868A1 (en) 1972-02-24 1972-02-24 Carboxy substd benzophenone derivs - as analgesics and antiinflammatory agents

Publications (2)

Publication Number Publication Date
FR2172868A1 true FR2172868A1 (en) 1973-10-05
FR2172868B1 FR2172868B1 (en) 1975-06-13

Family

ID=9094117

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7206402A Granted FR2172868A1 (en) 1972-02-24 1972-02-24 Carboxy substd benzophenone derivs - as analgesics and antiinflammatory agents

Country Status (1)

Country Link
FR (1) FR2172868A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0170105A2 (en) * 1984-07-07 1986-02-05 Koichi Prof. Dr. Shudo Benzoic acid derivatives
DE3615339A1 (en) * 1985-05-07 1986-11-13 Oreal TOPICAL SKIN TREATMENT PRODUCTS BASED ON SALICYL ACID DERIVATIVES
EP0514264A1 (en) * 1991-05-13 1992-11-19 Centre International De Recherches Dermatologiques Galderma, ( Cird Galderma) Biaromatic compounds derived from compounds having a salicylic configuration, their preparation process and their use in human and veterinary medicine and in cosmetics

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0170105A2 (en) * 1984-07-07 1986-02-05 Koichi Prof. Dr. Shudo Benzoic acid derivatives
EP0170105A3 (en) * 1984-07-07 1986-03-26 Koichi Prof. Dr. Shudo Benzoic acid derivatives
DE3615339A1 (en) * 1985-05-07 1986-11-13 Oreal TOPICAL SKIN TREATMENT PRODUCTS BASED ON SALICYL ACID DERIVATIVES
FR2581542A1 (en) * 1985-05-07 1986-11-14 Oreal TOPICAL COMPOSITIONS FOR THE TREATMENT OF SKIN BASED ON SALICYLIC ACID DERIVATIVES
US4767750A (en) * 1985-05-07 1988-08-30 L'oreal Topical compositions intended for skin treatment containing salicylic acid derivatives
EP0514264A1 (en) * 1991-05-13 1992-11-19 Centre International De Recherches Dermatologiques Galderma, ( Cird Galderma) Biaromatic compounds derived from compounds having a salicylic configuration, their preparation process and their use in human and veterinary medicine and in cosmetics
FR2676439A1 (en) * 1991-05-13 1992-11-20 Cird Galderma NOVEL BI-AROMATIC COMPOUNDS DERIVED FROM SALICYLIC MOTIF, PROCESS FOR THEIR PREPARATION AND THEIR USE IN HUMAN AND VETERINARY MEDICINE AS WELL AS IN COSMETICS
WO1992020643A1 (en) * 1991-05-13 1992-11-26 Centre International De Recherches Dermatologiques Galderma (Cird Galderma) Novel bi-aromatic compounds derived from a salicilic pattern, method of preparation and use in human and veterinary medecine and in cosmetics
US5476860A (en) * 1991-05-13 1995-12-19 Centre International De Recherches Dermatologiques (Cird Galderma) Diaromatic compounds derived from a salicylic unit and their use in human and veterinary medicine and in cosmetics
US5654331A (en) * 1991-05-13 1997-08-05 Centre International De Recherches Dermatologiques Galderma (Cird Galderma) Diaromatic compounds derived from a salicylic unit and their use in human and veterinary medicine and in cosmetics

Also Published As

Publication number Publication date
FR2172868B1 (en) 1975-06-13

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Legal Events

Date Code Title Description
CA Change of address
ST Notification of lapse