DE3278402D1 - Ultrapurificated factor viii : c preparation - Google Patents
Ultrapurificated factor viii : c preparationInfo
- Publication number
- DE3278402D1 DE3278402D1 DE8282306677T DE3278402T DE3278402D1 DE 3278402 D1 DE3278402 D1 DE 3278402D1 DE 8282306677 T DE8282306677 T DE 8282306677T DE 3278402 T DE3278402 T DE 3278402T DE 3278402 D1 DE3278402 D1 DE 3278402D1
- Authority
- DE
- Germany
- Prior art keywords
- ultrapurificated
- preparation
- factor viii
- viii
- factor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229960000301 factor viii Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
- Y10S530/813—Carrier is a saccharide
- Y10S530/814—Cellulose or derivatives thereof
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
- Y10S530/83—Plasma; serum
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- External Artificial Organs (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/330,105 US4361509A (en) | 1981-12-14 | 1981-12-14 | Ultrapurification of factor VIII using monoclonal antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3278402D1 true DE3278402D1 (de) | 1988-06-01 |
Family
ID=23288328
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3280469T Expired - Lifetime DE3280469T2 (de) | 1981-12-14 | 1982-12-14 | Ultrareinigung des Faktors VIII. |
DE8282306677T Expired DE3278402D1 (de) | 1981-12-14 | 1982-12-14 | Ultrapurificated factor viii : c preparation |
DE1993175054 Active DE19375054I2 (de) | 1981-12-14 | 1982-12-14 | Ultragereinigte Faktor VIII: C-Zubereitung. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3280469T Expired - Lifetime DE3280469T2 (de) | 1981-12-14 | 1982-12-14 | Ultrareinigung des Faktors VIII. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE1993175054 Active DE19375054I2 (de) | 1981-12-14 | 1982-12-14 | Ultragereinigte Faktor VIII: C-Zubereitung. |
Country Status (10)
Country | Link |
---|---|
US (1) | US4361509A (de) |
EP (1) | EP0083483B2 (de) |
JP (4) | JPH0723321B2 (de) |
AR (1) | AR230954A1 (de) |
AU (1) | AU545770B2 (de) |
CA (1) | CA1208130A (de) |
DE (3) | DE3280469T2 (de) |
LU (1) | LU88333I2 (de) |
NL (1) | NL930118I2 (de) |
WO (1) | WO1983002114A1 (de) |
Families Citing this family (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5582824A (en) * | 1981-10-19 | 1996-12-10 | Genentech, Inc. | Recombinant DES-CYS-TYR-CYS human immune interferon |
US4361509A (en) * | 1981-12-14 | 1982-11-30 | Scripps Clinic And Research Foundation | Ultrapurification of factor VIII using monoclonal antibodies |
CA1209907A (en) * | 1982-04-12 | 1986-08-19 | Richard M. Bartholomew | Method of affinity purification employing monoclonal antibodies |
US4397841A (en) * | 1982-06-28 | 1983-08-09 | Monsanto Company | Production of blood coagulation factor VIII:C |
US4614795A (en) * | 1982-08-05 | 1986-09-30 | University Of Rochester | Deglycosylated Human Factor VIII:C |
US4495175A (en) * | 1982-08-05 | 1985-01-22 | University Of Rochester | Preparation of highly purified human antihemophilic factor |
US4558005A (en) * | 1982-09-13 | 1985-12-10 | University Patents, Inc. | Monoclonal anti-erythropoietin |
US5614500A (en) * | 1983-03-04 | 1997-03-25 | The Scripps Research Institute | Compositions containing highly purified factor IX proteins prepared by immunoaffinity chromatography |
US5055557A (en) * | 1983-03-04 | 1991-10-08 | Scripps Clinic & Research Foundation | Ultrapurification of factor IX and other vitamin K-dependent proteins |
EP0118256B1 (de) * | 1983-03-04 | 1992-05-13 | Scripps Clinic And Research Foundation | Immunoadsorbens und Verfahren zur Zurückgewinnung von Vitamin-K-abhängigen Proteinen mittels dieses Adsorbens |
WO1984003628A1 (en) | 1983-05-09 | 1984-09-27 | Nordisk Insulinlab | A concentrate of the antihemophilic factor viii and a process for producing it |
US4657894A (en) * | 1983-03-31 | 1987-04-14 | Scripps Clinic & Research Foundation | New factor VIII coagulant polypeptides |
AU572128B2 (en) * | 1983-03-31 | 1988-05-05 | Scripps Clinic And Research Foundation | New factor viii, coagulant polypeptides and monoclonal antibodies |
US4649132A (en) * | 1983-03-31 | 1987-03-10 | Scripps Clinic And Research Foundation | Treatment of Factor VIII inhibitors |
US5362854A (en) * | 1983-03-31 | 1994-11-08 | Scripps Clinic & Research Foundation | Factor VIII coagulant polypeptides: method of making |
AT379510B (de) * | 1983-05-20 | 1986-01-27 | Immuno Ag | Verfahren zur herstellung einer faktor viii (ahf) -haeltigen praeparation |
US4681930A (en) * | 1983-09-20 | 1987-07-21 | Hoffmann-La Roche Inc. | Immune interferon and a method for its extraction and purification |
US6258938B1 (en) | 1983-10-28 | 2001-07-10 | Ne Medical Center Hospital, Inc. | Method for the purification and isolation of blood clotting proteins using conformation specific antibodies |
JPS61500226A (ja) * | 1983-10-28 | 1986-02-06 | ニュ−・イングランド・メディカル・センタ−・ホスピタルズ・インコ−ポレ−テッド | コンホメ−ション特異性抗体を用いる血液凝固タンパク質の精製および単離法 |
WO1985001961A1 (en) * | 1983-10-28 | 1985-05-09 | Genetics Institute | Production of factor viii and related products |
US4945041A (en) * | 1983-11-17 | 1990-07-31 | Board Of Regents | Monoclonal antibodies for Mycoplasma pneumoniae and use for diagnosis of pneumonia |
US4469630A (en) * | 1983-11-25 | 1984-09-04 | J. T. Baker Chemical Co. | Purification of monoclonal antibodies |
US4508709A (en) * | 1983-12-05 | 1985-04-02 | Armour Pharmaceutical Company | Process for purifying factor VIII:C |
US4855238A (en) | 1983-12-16 | 1989-08-08 | Genentech, Inc. | Recombinant gamma interferons having enhanced stability and methods therefor |
MX9203641A (es) * | 1983-12-16 | 1992-07-01 | Genentech Inc | Interferones gamma recombinantes que poseen estabilidad mejorada y metodos biotecnologicos para su obtencion. |
US4568488A (en) * | 1984-01-11 | 1986-02-04 | Lee Huang Sylvia | Reverse immunoaffinity chromatography purification method |
US4716117A (en) * | 1984-10-26 | 1987-12-29 | Chiron Corporation | Monoclonal antibodies to factor VIIIC |
JPH0764879B2 (ja) * | 1984-01-12 | 1995-07-12 | チロン コ−ポレイシヨン | フアクタ−v▲iii▼cに対するモノクロ−ナル抗体 |
US5045455A (en) * | 1984-01-12 | 1991-09-03 | Chiron Corporation | Factor VIII:C cDNA cloning and expression |
US7138505B1 (en) | 1984-01-12 | 2006-11-21 | Novartis Vaccines And Diagnostics, Inc. | Factor VIII:C nucleic acid molecules |
US5004804A (en) * | 1984-01-12 | 1991-04-02 | Nordisk Gentofte | Method and composition for preparation of factor VIIIC |
GB8403473D0 (en) * | 1984-02-09 | 1984-03-14 | Special Trustees For St Thomas | Purification of factor viii |
ZA852099B (en) * | 1984-03-26 | 1985-12-24 | Meloy Lab | Recombinant factor viii-c. |
IL74909A (en) * | 1984-04-20 | 1992-01-15 | Genentech Inc | Preparation of functional human factor viii and dna sequences,expression vectors,transformed microorganisms and cell lines used therein |
US4965199A (en) * | 1984-04-20 | 1990-10-23 | Genentech, Inc. | Preparation of functional human factor VIII in mammalian cells using methotrexate based selection |
US4710381A (en) * | 1984-05-22 | 1987-12-01 | The Blood Center Of Southeastern Wisconsin | Method for maintaining intact, non-degraded factor VIII/von-Willebrand factor during blood processing |
US5149787A (en) * | 1984-05-22 | 1992-09-22 | The Blood Center Research Foundation | Method for maintaining intact, non-degraded factor VIII/von-Willebrand factor during blood processing |
US4604235A (en) * | 1984-05-23 | 1986-08-05 | J. T. Baker Chemical Company | Purification of monoclonal antibodies |
FI852866L (fi) * | 1984-07-27 | 1986-01-28 | Meloy Lab | Rekombinantfaktor viii-r. |
US4693985A (en) * | 1984-08-21 | 1987-09-15 | Pall Corporation | Methods of concentrating ligands and active membranes used therefor |
EP0182448A3 (de) * | 1984-08-24 | 1987-10-28 | Genetics Institute, Inc. | Verfahren zur Herstellung von Faktor VIII und verwandte Produkte |
FR2570276B1 (fr) * | 1984-09-18 | 1987-09-04 | Immunotech Sa | Procede d'obtention du complexe fviii/vwf a usage therapeutique et produits en resultant |
DK525384D0 (da) * | 1984-11-05 | 1984-11-05 | Nordisk Insulinlab | Praeparat paa basis af faktor viii til behandling af haemofili a inhibitorpatienter samt fremgangsmaade til fremstilling af et saadan praeparat |
US4560504A (en) * | 1984-12-06 | 1985-12-24 | Uop Inc. | Carboxyl anchored immobilized antibodies |
US4933280A (en) * | 1984-12-11 | 1990-06-12 | California Biotechnology Inc. | Recombinant DNA sequence encoding Alveolar Surfactant Protein |
SE8501050D0 (sv) * | 1985-03-05 | 1985-03-05 | Kabivitrum Ab | Biologically active fragments of human antihemophilic factor and method for preparation thereof |
GR860984B (en) * | 1985-04-17 | 1986-08-18 | Zymogenetics Inc | Expression of factor vii and ix activities in mammalian cells |
CA1297815C (en) * | 1985-06-07 | 1992-03-24 | Barry S. Coller | Fibrinogen blocking monoclonal antibody |
GB8516570D0 (en) * | 1985-07-01 | 1985-08-07 | Common Services Agency For The | Coupling reaction |
US4758657A (en) * | 1985-07-11 | 1988-07-19 | Armour Pharmaceutical Company | Method of purifying Factor VIII:C |
GB2178533B (en) * | 1985-07-22 | 1989-07-19 | Asahi Chemical Ind | Analytical method of enzyme precursors and device therefor |
DE3707213A1 (de) * | 1987-03-06 | 1988-09-15 | Behringwerke Ag | Verfahren zur herstellung von faktor viii:c-mangelplasma und ein so erhaltenes mangelplasma |
CA1339946C (en) * | 1987-03-31 | 1998-07-07 | Michael J. Griffith | Ultrapurification process for polypeptides |
US5043429B1 (en) * | 1987-05-01 | 1997-10-14 | Scripps Research Inst | Protein fragments containing factor VIII binding domain of von willebrand factor |
US4774323A (en) * | 1987-06-29 | 1988-09-27 | Rorer Pharmaceutical Corporation | Purification of von Willebrand Factor solutions using gel permeation chromatography |
US4831118A (en) * | 1987-08-07 | 1989-05-16 | Scripps Clinic And Research Foundation | Flouroplastic immunoaffinity columns for purification of blood proteins |
IL88309A0 (en) * | 1987-11-17 | 1989-06-30 | Scripps Clinic Res | Peptides for use in the purification of factor viii |
EP0321835B1 (de) * | 1987-12-21 | 1994-09-28 | Miles Inc. | Faktor VIII- Gelfiltration |
JP2761881B2 (ja) * | 1988-03-10 | 1998-06-04 | チッソ株式会社 | 抗体を固定化したアフイニテイクロマトグラフイ用担体 |
FR2632309B1 (fr) * | 1988-06-07 | 1990-08-24 | Lille Transfusion Sanguine | Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus |
DE3904354A1 (de) | 1989-02-14 | 1990-08-16 | Behringwerke Ag | Pasteurisiertes, gereinigtes von willebrand-faktor-konzentrat und verfahren zu seiner herstellung |
FR2644064B1 (fr) * | 1989-02-17 | 1994-05-27 | Aquitaine Dev Transf Sanguine | Procede de fabrication du facteur antihemophilique fviiic ayant une tres haute purete et facteur antihemophilique fviiic ainsi obtenu, ainsi que composition pharmaceutique le contenant |
US5252711A (en) * | 1989-06-01 | 1993-10-12 | The Gillette Company | Monoclonal antibodies useful in deodorizing skin and antibody fragments thereof |
DE69016656T2 (de) * | 1989-06-15 | 1995-05-24 | Smith Jun | Vorrichtung zur inaktivierung infektioeser erreger und zur verhinderung der koagulierung in biologischen flüssigkeiten. |
US5110907A (en) * | 1989-08-01 | 1992-05-05 | Alpha Therapeutic Corporation | Factor viii complex purification using heparin affinity chromatography |
DE3926034C3 (de) * | 1989-08-07 | 1996-11-21 | Behringwerke Ag | Verfahren zur Herstellung eines stabilen Faktors VIII |
FR2651437A1 (fr) * | 1989-09-05 | 1991-03-08 | Lille Transfusion Sanguine | Procede de preparation de concentre du complexe facteur viii-facteur von willebrand de la coagulation sanguine a partir de plasma total. |
IT1248723B (it) * | 1990-06-12 | 1995-01-26 | Scalvo S P A | Processo per la purificazione del fattore viii e fattore viii ottenuto con tale processo |
US5279956A (en) * | 1991-06-24 | 1994-01-18 | The Scripps Research Institute | Activated protein C polypeptides and anti-peptide antibodies, diagnostic methods and systems for inhibiting activated protein C |
US5321123A (en) * | 1991-07-02 | 1994-06-14 | The Scripps Research Institute | Protein S polypeptides and anti-peptide antibodies that inhibit protein S binding to C4B binding protein, diagnostic systems and therapeutic methods |
US5278289A (en) * | 1991-11-12 | 1994-01-11 | Johnson Alan J | Antihemophilic factor stabilization |
US5288853A (en) * | 1992-04-30 | 1994-02-22 | Alpha Therapeutic Corporation | Factor viii purification process |
GB9501040D0 (en) | 1995-01-19 | 1995-03-08 | Quadrant Holdings Cambridge | Dried composition |
AT405403B (de) | 1997-02-27 | 1999-08-25 | Immuno Ag | Reinigung von von willebrand-faktor durch kationenaustauscherchromatographie |
AT406867B (de) | 1997-02-27 | 2000-10-25 | Immuno Ag | Verfahren zur gewinnung von hochreinem vwf oder faktor viii/vwf-komplex |
US5994310A (en) * | 1998-09-03 | 1999-11-30 | Bayer Corporation | Peptide ligands for affinity purification of human Factor VIII |
US7112438B2 (en) * | 1999-01-04 | 2006-09-26 | Dyax Corp. | Binding molecules for human factor VIII and factor VIII-like proteins |
US7879621B2 (en) * | 2003-05-08 | 2011-02-01 | Phynexus, Inc. | Open channel solid phase extraction systems and methods |
DE10246125A1 (de) * | 2002-10-01 | 2004-04-15 | Aventis Behring Gmbh | Konzentrat eines Faktor VIII:C-haltigen von-Willebrand-Faktors und das dazu gehörige Verfahren |
CN103170309B (zh) * | 2013-03-12 | 2014-10-29 | 中国农业大学 | 一种莱克多巴胺抗体免疫亲和层析柱及其应用 |
CN110382547B (zh) * | 2016-12-14 | 2023-06-06 | 盼展生物技术有限公司 | 抗凝血因子viii抗体及其用途 |
WO2019083319A2 (ko) | 2017-10-27 | 2019-05-02 | 주식회사 녹십자홀딩스 | 본 빌리브란트 인자(vwf)의 함량 조절이 가능한 제8인자 및 본 빌리브란트 인자를 포함하는 조성물의 제조방법 |
US10934340B2 (en) | 2018-03-21 | 2021-03-02 | Baxalta Incorporated | Separation of VWF and VWF propeptide by chromatographic methods |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3652530A (en) * | 1967-08-28 | 1972-03-28 | American Nat Red Cross | Antihemophilic factor prepared from blood plasma using polyethylene glycol |
US3631018A (en) * | 1970-05-01 | 1971-12-28 | Baxter Laboratories Inc | Production of stable high-potency human ahf using polyethylene glycol and glycine to fractionate a cryoprecipitate of ahf concentrate |
US3682881A (en) * | 1970-10-02 | 1972-08-08 | Baxter Laboratories Inc | Fractionation of plasma using glycine and polyethylene glycol |
US4069216A (en) * | 1975-06-16 | 1978-01-17 | Edward Shanbrom, Inc. | Simplified methods for preparation of very high purity Factor VIII concentrate |
US4188318A (en) * | 1975-06-16 | 1980-02-12 | Edward Shanbrom | Simplified method for preparation of high yield, high purity Factor VIII concentrate |
FR2363577A1 (fr) * | 1976-09-03 | 1978-03-31 | Recherches Hematologiques | Procede simplifie pour preparer avec un rendement eleve du concentre de facteur antihemophilique pur |
US4137223A (en) * | 1977-05-16 | 1979-01-30 | Edward Shanbrom, Inc. | Method of preserving blood plasma II |
CA1074698A (en) * | 1977-12-19 | 1980-04-01 | Gail A. Rock | Method of collecting anti-hemophilic factor viii from blood and blood plasma |
US4361509A (en) * | 1981-12-14 | 1982-11-30 | Scripps Clinic And Research Foundation | Ultrapurification of factor VIII using monoclonal antibodies |
-
1981
- 1981-12-14 US US06/330,105 patent/US4361509A/en not_active Ceased
-
1982
- 1982-12-08 CA CA000417226A patent/CA1208130A/en not_active Expired
- 1982-12-10 WO PCT/US1982/001726 patent/WO1983002114A1/en unknown
- 1982-12-13 AU AU91456/82A patent/AU545770B2/en not_active Expired
- 1982-12-14 EP EP82306677A patent/EP0083483B2/de not_active Expired - Lifetime
- 1982-12-14 JP JP57217928A patent/JPH0723321B2/ja not_active Expired - Lifetime
- 1982-12-14 DE DE3280469T patent/DE3280469T2/de not_active Expired - Lifetime
- 1982-12-14 AR AR291580A patent/AR230954A1/es active
- 1982-12-14 DE DE8282306677T patent/DE3278402D1/de not_active Expired
- 1982-12-14 DE DE1993175054 patent/DE19375054I2/de active Active
-
1991
- 1991-07-18 JP JP3202313A patent/JPH0784480B2/ja not_active Expired - Lifetime
-
1993
- 1993-06-24 LU LU88333C patent/LU88333I2/fr unknown
- 1993-06-30 NL NL930118C patent/NL930118I2/nl unknown
-
1994
- 1994-10-06 JP JP6242965A patent/JP2554848B2/ja not_active Expired - Lifetime
-
1996
- 1996-05-07 JP JP8112373A patent/JPH08301787A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
DE3280469D1 (de) | 1995-08-31 |
JPH08301787A (ja) | 1996-11-19 |
EP0083483A1 (de) | 1983-07-13 |
DE19375054I2 (de) | 2005-05-12 |
DE3280469T2 (de) | 1996-01-04 |
JPS58131918A (ja) | 1983-08-06 |
JP2554848B2 (ja) | 1996-11-20 |
JPH0616700A (ja) | 1994-01-25 |
AU9145682A (en) | 1983-06-23 |
US4361509A (en) | 1982-11-30 |
NL930118I2 (nl) | 1995-05-16 |
JPH07238034A (ja) | 1995-09-12 |
NL930118I1 (nl) | 1993-11-01 |
EP0083483B1 (de) | 1988-04-27 |
CA1251152C (de) | 1989-03-14 |
AU545770B2 (en) | 1985-08-01 |
JPH0784480B2 (ja) | 1995-09-13 |
EP0083483B2 (de) | 1997-09-17 |
CA1208130A (en) | 1986-07-22 |
LU88333I2 (fr) | 1994-05-04 |
AR230954A1 (es) | 1984-08-31 |
WO1983002114A1 (en) | 1983-06-23 |
JPH0723321B2 (ja) | 1995-03-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE3278402D1 (de) | Ultrapurificated factor viii : c preparation | |
NO823019L (no) | Sjampo | |
DK163170C (da) | Tandbehandlingsmiddel | |
BR8203377A (pt) | Dentifricio | |
DE3274796D1 (de) | Dentifrice | |
FI821837A (fi) | Avlastningssystem foer avlastningsunderlag foer arkris i en kontinuerligt verksam arkformningsmaskin | |
FI820441L (fi) | Anordning i fartyg | |
AT382116B (de) | Geraeuschgedaempftes schienenrad | |
AR228298A1 (es) | Cubo-rompecabezas | |
BR8203559A (pt) | Dentifricio | |
AT372860B (de) | Schipaar | |
FI811403L (fi) | Kompakt pressparti i pappersmaskin | |
DK152219C (da) | Azopigmentpraeparater | |
FI821078A0 (fi) | Formskor foer torkpartiet i en pappersmaskin | |
FI821802A0 (fi) | Taetningsanordning foer drivaxeln i en hoegtryckspump | |
FI822144L (fi) | Foerbaettrat eloeverfoerings- och distributionssystem i vilket luftledning anvaendes | |
FI813942L (fi) | Anordning foer automatisk cirkulation i avloppsvattenpumpstation | |
FI822499L (fi) | Modellerings- eller formmassa | |
FI820686L (fi) | Anordning foer verktygsbyte i en traebearbetningsmaskin | |
FI820946L (fi) | Effektmatningskrets i 2-ledningstermostat | |
FI823491A0 (fi) | Kopplingsklaemma foer fasvalet i en stroemdistributionsledning | |
FI821938A0 (fi) | Foerbaettringar i filteranordningar | |
DK305782A (da) | Herbicidt praeparat | |
IT1198416B (it) | Procedimento di preparazione di mononitroclorobenzene | |
FI820701L (fi) | Anordning i potatisupptagningsanordning |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent | ||
V448 | Application of spc |
Free format text: PRODUCT NAME: AN BLUTGERINNUNGSFAKTOR VIII ANGEREICHERTE HUMANPLASMAFRAKTION MIT EINER BLUTGERINNUNGSFAKTOR-VIII-AKTIVITAET VON 250 I.E., 500 I.E., 1000 I.E.; REGISTRATION NO/DATE: 16471.00.00, 16471.01.00, 16471.02.00; 19900212 Spc suppl protection certif: 193 75 054 Filing date: 19930623 |
|
8327 | Change in the person/name/address of the patent owner |
Owner name: THE SCRIPPS RESEARCH INSTITUTE, LA JOLLA, CALIF., |
|
8366 | Restricted maintained after opposition proceedings | ||
V457 | Spc granted |
Free format text: PRODUCT NAME: AN BLUTGERINNUNGSFAKTOR VIII ANGEREICHERTE HUMANPLASMAFRAKTION MIT EINER BLUTGERINNUNGSFAKTOR-VIII-AKTIVITAET VON 250 I.E., 500 I.E., 1000 I.E.; REGISTRATION NO/DATE: 16471.00.00, 16471.01.00, 16471.02.00; 19900212 Spc suppl protection certif: 193 75 054 Filing date: 19930623 |
|
V464 | Spc expired |
Free format text: PRODUCT NAME: AN BLUTGERINNUNGSFAKTOR VIII ANGEREICHERTE HUMANPLASMAFRAKTION MIT EINER BLUTGERINNUNGSFAKTOR-VIII-AKTIVITAET VON 250 I.E., 500 I.E., 1000 I.E.; REGISTRATION NO/DATE: 16471.00.00, 16471.01.00, 16471.02.00; 19900212 Spc suppl protection certif: 193 75 054 Filing date: 19930623 |