DE2811849C2 - - Google Patents

Info

Publication number
DE2811849C2
DE2811849C2 DE2811849A DE2811849A DE2811849C2 DE 2811849 C2 DE2811849 C2 DE 2811849C2 DE 2811849 A DE2811849 A DE 2811849A DE 2811849 A DE2811849 A DE 2811849A DE 2811849 C2 DE2811849 C2 DE 2811849C2
Authority
DE
Germany
Prior art keywords
trimethyl
methano
test
hexahydro
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE2811849A
Other languages
German (de)
English (en)
Other versions
DE2811849A1 (de
Inventor
William Francis Averill Park N.Y. Us Michne
Thomas Richard Delmar N.Y. Us Lewis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STWB Inc
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/818,713 external-priority patent/US4119628A/en
Priority to US05/818,713 priority Critical patent/US4119628A/en
Priority to SE7710049A priority patent/SE443362B/xx
Priority to GB38944/77A priority patent/GB1551562A/en
Priority to CA286,972A priority patent/CA1095905A/en
Priority to NLAANVRAGE7710325,A priority patent/NL187630C/xx
Priority to BE1008388A priority patent/BE858866A/xx
Priority to DK418577A priority patent/DK153945C/da
Priority to CH81881A priority patent/CH626882A5/fr
Priority to DE19772742715 priority patent/DE2742715A1/de
Priority to LU78162A priority patent/LU78162A1/xx
Priority to CH1161877A priority patent/CH624939A5/fr
Priority to JP11452077A priority patent/JPS5340777A/ja
Priority to AU29030/77A priority patent/AU514085B2/en
Priority to FR7728584A priority patent/FR2375216A1/fr
Priority to FR7803369A priority patent/FR2378768A1/fr
Priority claimed from US05/877,166 external-priority patent/US4180667A/en
Priority to US05/877,166 priority patent/US4180667A/en
Priority to US05/878,308 priority patent/US4148794A/en
Priority to BE1008770A priority patent/BE864950A/xx
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Priority to DE19782811849 priority patent/DE2811849A1/de
Publication of DE2811849A1 publication Critical patent/DE2811849A1/de
Priority to CA361,860A priority patent/CA1110243A/en
Priority to US06/243,031 priority patent/US4335243A/en
Priority to JP59198393A priority patent/JPS60142963A/ja
Priority to JP59198392A priority patent/JPS60142962A/ja
Priority to SE8501168A priority patent/SE463420B/sv
Publication of DE2811849C2 publication Critical patent/DE2811849C2/de
Application granted granted Critical
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/82—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/08—Aza-anthracenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19782811849 1974-05-20 1978-03-17 2,6-methano-3-benzazocine, verfahren zu deren herstellung und arzneimittel Granted DE2811849A1 (de)

Priority Applications (24)

Application Number Priority Date Filing Date Title
US05/818,713 US4119628A (en) 1976-09-22 1977-07-25 Process for preparing hexahydro-11 (eq)-CH2 CH2 COR5 -2,6-methano-3-benzazocines
SE7710049A SE443362B (sv) 1976-09-22 1977-09-07 Forfarande for framstellning av hexahydro-2,6-metano-3-bensazociner
GB38944/77A GB1551562A (en) 1976-09-22 1977-09-19 2,5-methanobenzo (g) quinoline-3-carboxylate esters
CA286,972A CA1095905A (en) 1976-09-22 1977-09-19 2,5-methanobenzo¬g| quinoline-3-carboxylate esters
NLAANVRAGE7710325,A NL187630C (nl) 1976-09-22 1977-09-20 Werkwijze ter bereiding van benzazocinederivaten.
BE1008388A BE858866A (fr) 1976-09-22 1977-09-20 2,5-methanobenzo (g) quinoleine-3-carboxylates (esters)
DK418577A DK153945C (da) 1976-09-22 1977-09-21 Alkyl-3-acyl-1,2,3,4,4a,5,10,10a-octahydro-2,5-methanobenzo(g)quinolin-3-carboxylater til brug som mellemprodukter ved fremstilling af 11(eq)-(2-acylethyl)-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazociner, samt fremgangsmaade til fremstilling af de naevnte benzazociner
AU29030/77A AU514085B2 (en) 1976-09-22 1977-09-22 2, 5-Methanobenzo(g) Quinoline 3-carboxylate esters
DE19772742715 DE2742715A1 (de) 1976-09-22 1977-09-22 2,5-methanobenzo eckige klammer auf g eckige klammer zu chinolin-3-carboxylatester
LU78162A LU78162A1 (da) 1976-09-22 1977-09-22
CH1161877A CH624939A5 (da) 1976-09-22 1977-09-22
JP11452077A JPS5340777A (en) 1976-09-22 1977-09-22 2*55methnobenzo *g* quinolinee33carboxylic acid ester
CH81881A CH626882A5 (da) 1976-09-22 1977-09-22
FR7728584A FR2375216A1 (fr) 1976-09-22 1977-09-22 2,5-methanobenzo (g) quinoleine-3-carboxylates (esters)
FR7803369A FR2378768A1 (fr) 1976-09-22 1978-02-07 2,6-methano-3-benzazocines et leur utilisation comme medicaments
US05/877,166 US4180667A (en) 1974-05-20 1978-02-13 2-Azabicyclo[2.2.2]oct-5-enes
US05/878,308 US4148794A (en) 1976-09-22 1978-02-16 Lower-alkyl 3-R5 CO-octahydro-2,5-methanobenzo[g]quinoline-3-carboxylates
BE1008770A BE864950A (fr) 1976-09-22 1978-03-16 2,6-methano-3-benzazocines
DE19782811849 DE2811849A1 (de) 1976-09-22 1978-03-17 2,6-methano-3-benzazocine, verfahren zu deren herstellung und arzneimittel
CA361,860A CA1110243A (en) 1976-09-22 1980-10-08 2,5-methanobenzo [5] quinoline-3-carboxylate esters
US06/243,031 US4335243A (en) 1978-02-13 1981-03-12 Oximes of 11-(3-oxooctyl)-hexahydro-2,6-methano-3-benzazocines
JP59198393A JPS60142963A (ja) 1976-09-22 1984-09-21 ２，６−メタノ−３−ベンゾアゾシン誘導体およびその製造方法
JP59198392A JPS60142962A (ja) 1976-09-22 1984-09-21 ２，５−メタノベンゾ〔ｇ〕キノリン−３−カルボン酸エステルおよびその製造方法
SE8501168A SE463420B (sv) 1976-09-22 1985-03-08 Alkyl-3-acyl-oktahydro-2,5-metanobenso(g)kinolin-3-karboxylater, till anvaendning som mellanprodukter foer framstaellning av 11(eg)-(2-acyletyl)-hexahydro-2,6-metano-3-bensazociner, samt foerfarande foer deras framstaellning

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US72537176A 1976-09-22 1976-09-22
US78574677A 1977-04-08 1977-04-08
US05/818,713 US4119628A (en) 1976-09-22 1977-07-25 Process for preparing hexahydro-11 (eq)-CH2 CH2 COR5 -2,6-methano-3-benzazocines
US05/877,166 US4180667A (en) 1974-05-20 1978-02-13 2-Azabicyclo[2.2.2]oct-5-enes
DE19782811849 DE2811849A1 (de) 1976-09-22 1978-03-17 2,6-methano-3-benzazocine, verfahren zu deren herstellung und arzneimittel

Publications (2)

Publication Number Publication Date
DE2811849A1 DE2811849A1 (de) 1979-09-27
DE2811849C2 true DE2811849C2 (da) 1990-05-23

Family

ID=27510522

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19782811849 Granted DE2811849A1 (de) 1974-05-20 1978-03-17 2,6-methano-3-benzazocine, verfahren zu deren herstellung und arzneimittel

Country Status (2)

Country Link
BE (1) BE864950A (da)
DE (1) DE2811849A1 (da)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0019056A1 (en) * 1979-03-26 1980-11-26 Sterling Drug Inc. Process for preparing 11-lower alkylthio-3-oxo-lower-alkyl-hexahydro-2,6-methano-3-benzazocines

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3372165A (en) * 1960-12-01 1968-03-05 Sterling Drug Inc 1, 2, 3, 4, 5, 6-hexahydro-8-hydroxy-2, 6-methano-3-benzazocine derivatives
US3250678A (en) * 1963-01-16 1966-05-10 Sterling Drug Inc Analgesia producing benzazocines
US3345373A (en) * 1964-05-25 1967-10-03 Smith Kline French Lab 2-polymethylallyl-5, 9-dimethyl-6, 7-benzmorphans and derivatives
NL132139C (da) * 1966-05-20
US3932422A (en) * 1974-05-20 1976-01-13 Sterling Drug Inc. 8-Methylene-3-azabicyclo[3.3.1]non-6-en-4-ones
US4119628A (en) * 1976-09-22 1978-10-10 Sterling Drug Inc. Process for preparing hexahydro-11 (eq)-CH2 CH2 COR5 -2,6-methano-3-benzazocines

Also Published As

Publication number Publication date
DE2811849A1 (de) 1979-09-27
BE864950A (fr) 1978-09-18

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Legal Events

Date Code Title Description
8128 New person/name/address of the agent

Representative=s name: ZUMSTEIN SEN., F., DR. ASSMANN, E., DIPL.-CHEM. DR

8110 Request for examination paragraph 44
8125 Change of the main classification

Ipc: C07D221/26

8181 Inventor (new situation)

Free format text: MICHNE, WILLIAM FRANCIS, AVERILL PARK, N.Y., US LEWIS, THOMAS RICHARD, DELMAR, N.Y., US

D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee