DE2760287C2 - - Google Patents
Info
- Publication number
- DE2760287C2 DE2760287C2 DE2760287A DE2760287A DE2760287C2 DE 2760287 C2 DE2760287 C2 DE 2760287C2 DE 2760287 A DE2760287 A DE 2760287A DE 2760287 A DE2760287 A DE 2760287A DE 2760287 C2 DE2760287 C2 DE 2760287C2
- Authority
- DE
- Germany
- Prior art keywords
- syn
- acid
- thiazolyl
- formula
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
- C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7601834A FR2346014A1 (fr) | 1976-01-23 | 1976-01-23 | Nouvelles oximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
FR7617743A FR2361893A2 (fr) | 1976-01-23 | 1976-06-11 | Nouvelles oximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
FR7625051A FR2361894A2 (fr) | 1976-01-23 | 1976-08-18 | Nouvelles oximes derivees de l'acide 7-aminothiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
Publications (1)
Publication Number | Publication Date |
---|---|
DE2760287C2 true DE2760287C2 (xx) | 1988-04-14 |
Family
ID=27250574
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE2702501A Expired DE2702501C2 (de) | 1976-01-23 | 1977-01-21 | Oximderivate von 7-Aminothiazolylacetamidocephalosporansäure (syn-Isomere), ihre Herstellung und pharmazeutische Zusammensetzungen |
DE2760287A Expired DE2760287C2 (xx) | 1976-01-23 | 1977-01-21 | |
DE2759895A Expired DE2759895C2 (de) | 1976-01-23 | 1977-01-21 | Verwendung von syn-Alkoxyiminoderivaten von Aminothiazolylessigsäuren zur Herstellung entsprechender 7-Aminothiazolyl-syn-alkoxyiminoacetamidocephalosporansäuren |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE2702501A Expired DE2702501C2 (de) | 1976-01-23 | 1977-01-21 | Oximderivate von 7-Aminothiazolylacetamidocephalosporansäure (syn-Isomere), ihre Herstellung und pharmazeutische Zusammensetzungen |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE2759895A Expired DE2759895C2 (de) | 1976-01-23 | 1977-01-21 | Verwendung von syn-Alkoxyiminoderivaten von Aminothiazolylessigsäuren zur Herstellung entsprechender 7-Aminothiazolyl-syn-alkoxyiminoacetamidocephalosporansäuren |
Country Status (31)
Country | Link |
---|---|
JP (3) | JPS52102293A (xx) |
AR (1) | AR231985A1 (xx) |
AT (2) | AT355205B (xx) |
AU (1) | AU511680B2 (xx) |
BE (1) | BE850662A (xx) |
CA (1) | CA1319682C (xx) |
CH (1) | CH622264A5 (xx) |
CY (1) | CY1123A (xx) |
DD (2) | DD128594A5 (xx) |
DE (3) | DE2702501C2 (xx) |
DK (1) | DK161082C (xx) |
ES (2) | ES455089A1 (xx) |
GB (2) | GB1580621A (xx) |
GE (1) | GEP19970783B (xx) |
GR (1) | GR70302B (xx) |
HK (1) | HK50381A (xx) |
HU (1) | HU173110B (xx) |
IE (1) | IE45015B1 (xx) |
IL (2) | IL51192A (xx) |
IT (1) | IT1104601B (xx) |
KE (1) | KE3365A (xx) |
LU (1) | LU76624A1 (xx) |
MX (1) | MX4407E (xx) |
MY (1) | MY8500417A (xx) |
NL (1) | NL7700706A (xx) |
NZ (1) | NZ183150A (xx) |
PL (1) | PL122698B1 (xx) |
PT (1) | PT66099B (xx) |
SE (2) | SE440655B (xx) |
SU (1) | SU822754A3 (xx) |
YU (3) | YU41060B (xx) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2408613A2 (fr) * | 1977-07-19 | 1979-06-08 | Roussel Uclaf | Nouvelles oximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
GB1576625A (en) * | 1976-04-12 | 1980-10-08 | Fujisawa Pharmaceutical Co | Syn isomer 3,7 disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof |
DK162391C (da) * | 1976-04-12 | 1992-03-09 | Fujisawa Pharmaceutical Co | Analogifremgangsmaade til fremstilling af syn-isomerer af 3,7-disubstituerede 3-cephem-4-carboxylsyreforbindelser |
DE2715385A1 (de) * | 1976-04-14 | 1977-11-10 | Takeda Chemical Industries Ltd | Cephalosporinderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel |
PH17188A (en) | 1977-03-14 | 1984-06-14 | Fujisawa Pharmaceutical Co | New cephem and cepham compounds and their pharmaceutical compositions and method of use |
ZA781502B (en) * | 1977-03-14 | 1979-09-26 | Fujisawa Pharmaceutical Co | New cephem and cepham compounds and processes for preparation thereof |
DE2714880A1 (de) * | 1977-04-02 | 1978-10-26 | Hoechst Ag | Cephemderivate und verfahren zu ihrer herstellung |
FR2400519A1 (fr) * | 1977-08-17 | 1979-03-16 | Roussel Uclaf | Forme cristalline du sel de sodium d'un derive oximine de l'acide 7-amino-thiazolyl acetamido cephalosporanique, son procede de preparation et son application comme medicament |
JPS5444695A (en) * | 1977-09-13 | 1979-04-09 | Fujisawa Pharmaceut Co Ltd | 3,7-disubstituted-3-cephem-4-carboxylic acid and its salt and their preparation |
FR2410655A1 (fr) * | 1977-12-05 | 1979-06-29 | Roussel Uclaf | Nouvelles oximes derivees de l'acide 3-substitue 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
JPS5498795A (en) * | 1978-01-13 | 1979-08-03 | Takeda Chem Ind Ltd | Cephalosporin derivative and its preparation |
FR2387235A1 (fr) * | 1978-01-23 | 1978-11-10 | Fujisawa Pharmaceutical Co | Procede de preparation de composes d'acide 3,7-disubstitue-3-cephem-4-carboxylique et nouveaux produits ainsi obtenus, ayant une forte activite antibacterienne |
FR2432521A1 (fr) * | 1978-03-31 | 1980-02-29 | Roussel Uclaf | Nouvelles oximes o-substituees derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
SE445350B (sv) * | 1978-04-14 | 1986-06-16 | Roussel Uclaf | Oximderivat av 3-azidometyl-7-amino-tiazolyl-acetamido-cefalosporansyra och dess anvendning som antibiotika |
US4284631A (en) * | 1978-07-31 | 1981-08-18 | Fujisawa Pharmaceutical Co., Ltd. | 7-Substituted cephem compounds and pharmaceutical antibacterial compositions containing them |
FR2448543A1 (fr) * | 1979-02-09 | 1980-09-05 | Roussel Uclaf | Nouvelles oximes o-substituees par un radical comportant un ammonium quaternaire et derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
FR2461713A1 (fr) * | 1979-07-19 | 1981-02-06 | Roussel Uclaf | Nouvelles alcoyloximes substituees derivees de l'acide 7-(2-amino 4-thiazolyl) acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
FR2461712A1 (fr) * | 1979-07-23 | 1981-02-06 | Hoechst Ag | Procede de preparation de derives de cepheme |
JPS57154175A (en) * | 1981-03-16 | 1982-09-22 | Mitsui Toatsu Chem Inc | 2-thiazoleamine derivative, its preparation, and drug composition comprising it |
FR2506307A1 (fr) * | 1981-05-22 | 1982-11-26 | Roussel Uclaf | Nouveaux derives substitues de l'acide 2-(2-amino 4-thiazolyl) 2-hydroxyimino acetique et leur procede de preparation |
JPS57163386A (en) * | 1981-08-13 | 1982-10-07 | Takeda Chem Ind Ltd | Cephalosporin derivative and its production |
EP0238060B1 (en) | 1986-03-19 | 1992-01-08 | Banyu Pharmaceutical Co., Ltd. | Cephalosporin derivatives, processes for their preparation and antibacterial agents |
HUT53892A (en) * | 1989-04-07 | 1990-12-28 | Technologishen Kom Za Promy Mi | Process for producing synaminothiazolyl and synaminooxazolyl derivatives |
CN112457271A (zh) * | 2020-11-18 | 2021-03-09 | 河北合佳医药科技集团股份有限公司 | 一种氨噻肟酸中间体的连续流合成方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2223375A1 (de) * | 1971-05-14 | 1972-11-23 | Glaxo Lab Ltd | Antibiotika und Verfahren zu ihrer Herstellung |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1536281A (en) * | 1975-06-09 | 1978-12-20 | Takeda Chemical Industries Ltd | Cephem compounds |
DK154939C (da) | 1974-12-19 | 1989-06-12 | Takeda Chemical Industries Ltd | Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf |
DE2760123C2 (de) | 1976-01-23 | 1986-04-30 | Roussel-Uclaf, Paris | 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen |
JPS6011713B2 (ja) | 1976-09-08 | 1985-03-27 | 武田薬品工業株式会社 | セフアロスポリン誘導体およびその製造法 |
-
1976
- 1976-12-29 SE SE7614678A patent/SE440655B/xx not_active IP Right Cessation
- 1976-12-31 IL IL51192A patent/IL51192A/xx unknown
-
1977
- 1977-01-15 ES ES455089A patent/ES455089A1/es not_active Expired
- 1977-01-18 SU SU772439818A patent/SU822754A3/ru active
- 1977-01-19 YU YU137/77A patent/YU41060B/xx unknown
- 1977-01-19 AR AR266241A patent/AR231985A1/es active
- 1977-01-20 MX MX775372U patent/MX4407E/es unknown
- 1977-01-20 IT IT47727/77A patent/IT1104601B/it active Protection Beyond IP Right Term
- 1977-01-21 DE DE2702501A patent/DE2702501C2/de not_active Expired
- 1977-01-21 BE BE174311A patent/BE850662A/xx not_active IP Right Cessation
- 1977-01-21 DD DD7700197036A patent/DD128594A5/xx unknown
- 1977-01-21 DD DD7700200629A patent/DD132869A5/xx unknown
- 1977-01-21 HU HU77RO909A patent/HU173110B/hu unknown
- 1977-01-21 GB GB2640/77A patent/GB1580621A/en not_active Expired
- 1977-01-21 CH CH78777A patent/CH622264A5/fr not_active IP Right Cessation
- 1977-01-21 CA CA000270375A patent/CA1319682C/fr not_active Expired - Lifetime
- 1977-01-21 NZ NZ183150A patent/NZ183150A/xx unknown
- 1977-01-21 JP JP504977A patent/JPS52102293A/ja active Granted
- 1977-01-21 GB GB15561/79A patent/GB1580623A/en not_active Expired
- 1977-01-21 DK DK023677A patent/DK161082C/da active
- 1977-01-21 CY CY1123A patent/CY1123A/xx unknown
- 1977-01-21 LU LU76624A patent/LU76624A1/xx unknown
- 1977-01-21 PT PT66099A patent/PT66099B/pt unknown
- 1977-01-21 DE DE2760287A patent/DE2760287C2/de not_active Expired
- 1977-01-21 DE DE2759895A patent/DE2759895C2/de not_active Expired
- 1977-01-22 PL PL1977195504A patent/PL122698B1/pl unknown
- 1977-01-22 GR GR52630A patent/GR70302B/el unknown
- 1977-01-24 AT AT41277A patent/AT355205B/de not_active IP Right Cessation
- 1977-01-24 IE IE148/77A patent/IE45015B1/en not_active IP Right Cessation
- 1977-01-24 AU AU21579/77A patent/AU511680B2/en not_active Expired
- 1977-01-24 NL NL7700706A patent/NL7700706A/xx not_active Application Discontinuation
-
1978
- 1978-02-01 ES ES466539A patent/ES466539A1/es not_active Expired
-
1979
- 1979-03-20 AT AT0209479A patent/AT373592B/de not_active IP Right Cessation
- 1979-05-31 IL IL57445A patent/IL57445A0/xx not_active IP Right Cessation
-
1981
- 1981-10-22 HK HK503/81A patent/HK50381A/xx unknown
-
1982
- 1982-08-26 SE SE8204893A patent/SE455307B/sv not_active IP Right Cessation
-
1983
- 1983-01-04 YU YU11/83A patent/YU43143B/xx unknown
- 1983-01-04 YU YU00012/83A patent/YU1283A/xx unknown
-
1984
- 1984-01-11 KE KE3365A patent/KE3365A/xx unknown
-
1985
- 1985-12-30 MY MY417/85A patent/MY8500417A/xx unknown
-
1990
- 1990-04-19 JP JP2101872A patent/JPH03204868A/ja active Pending
-
1993
- 1993-01-20 JP JP5023427A patent/JPH05247013A/ja active Pending
- 1993-09-09 GE GEAP19931537A patent/GEP19970783B/en unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2223375A1 (de) * | 1971-05-14 | 1972-11-23 | Glaxo Lab Ltd | Antibiotika und Verfahren zu ihrer Herstellung |
Non-Patent Citations (1)
Title |
---|
In Betracht gezogene ältere Patente: DE-PS 25 60 398 DE-PS 25 59 942 DE-PS 25 56 736 In Betracht gezogene ältere Anmeldung: DE-OS 25 56 736 * |
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
Q172 | Divided out of (supplement): |
Ref country code: DE Ref document number: 2760123 |
|
8110 | Request for examination paragraph 44 | ||
8181 | Inventor (new situation) |
Free format text: HEYMES, ANDRE, ROMAINVILLE, FR LUTZ, ANDRE, SRASSBURG, FR |
|
8181 | Inventor (new situation) |
Free format text: HEYMES, ANDRE, ROMAINVILLE, FR LUTZ, ANDRE, DR., STRASSBURG, FR |
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AC | Divided out of |
Ref country code: DE Ref document number: 2760123 Format of ref document f/p: P |
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D2 | Grant after examination | ||
8364 | No opposition during term of opposition |