DE19882746T1 - Enzymvermittelte Modifikation von Fibrin für das Gewebs-Engineering - Google Patents
Enzymvermittelte Modifikation von Fibrin für das Gewebs-EngineeringInfo
- Publication number
- DE19882746T1 DE19882746T1 DE19882746T DE19882746T DE19882746T1 DE 19882746 T1 DE19882746 T1 DE 19882746T1 DE 19882746 T DE19882746 T DE 19882746T DE 19882746 T DE19882746 T DE 19882746T DE 19882746 T1 DE19882746 T1 DE 19882746T1
- Authority
- DE
- Germany
- Prior art keywords
- fibrin
- enzyme
- tissue engineering
- mediated modification
- mediated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/043—Proteins; Polypeptides; Degradation products thereof
- A61L31/046—Fibrin; Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/106—Fibrin; Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/225—Fibrin; Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0068—General culture methods using substrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
- A61F2310/00377—Fibrin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/56—Fibrin; Thrombin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Surgery (AREA)
- Dermatology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Vascular Medicine (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4214397P | 1997-04-03 | 1997-04-03 | |
PCT/US1998/006617 WO1998043686A1 (en) | 1997-04-03 | 1998-04-02 | Enzyme-mediated modification of fibrin for tissue engineering |
US09/057,052 US6331422B1 (en) | 1997-04-03 | 1998-04-08 | Enzyme-mediated modification of fibrin for tissue engineering |
Publications (1)
Publication Number | Publication Date |
---|---|
DE19882746T1 true DE19882746T1 (de) | 2001-10-18 |
Family
ID=26718917
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19882746T Withdrawn DE19882746T1 (de) | 1997-04-03 | 1998-04-02 | Enzymvermittelte Modifikation von Fibrin für das Gewebs-Engineering |
Country Status (7)
Country | Link |
---|---|
US (2) | US6331422B1 (de) |
EP (1) | EP1124590B1 (de) |
AU (1) | AU7245598A (de) |
CA (1) | CA2307954C (de) |
DE (1) | DE19882746T1 (de) |
GB (1) | GB2348426B (de) |
WO (1) | WO1998043686A1 (de) |
Families Citing this family (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7485440B2 (en) | 1995-09-27 | 2009-02-03 | The United States Of America As Represented By The Department Of Health And Human Services | Production of attenuated respiratory syncytial virus vaccines involving modification of M2 ORF2 |
US20020168718A1 (en) * | 1997-04-03 | 2002-11-14 | California Institute Of Technology | Enzyme-mediated modification of fibrin for tissue engineering |
US6894022B1 (en) * | 1998-08-27 | 2005-05-17 | Eidgenossische Technische Hochschule Zurich | Growth factor modified protein matrices for tissue engineering |
US7601685B2 (en) * | 1998-08-27 | 2009-10-13 | Eidgenossische Technische Hochschule Zurich | Growth factor modified protein matrices for tissue engineering |
US7241730B2 (en) | 1998-08-27 | 2007-07-10 | Universitat Zurich | Enzyme-mediated modification of fibrin for tissue engineering: fibrin formulations with peptides |
DE19945487A1 (de) * | 1999-09-22 | 2001-03-29 | Henkel Kgaa | Verfahren zur Restrukturierung keratinischer Fasern |
GB0011356D0 (en) * | 2000-05-12 | 2000-06-28 | Univ Nottingham Trent | Medical implant materials |
WO2001089584A2 (en) * | 2000-05-23 | 2001-11-29 | Amersham Health As | Contrast agents |
US6506365B1 (en) | 2000-09-25 | 2003-01-14 | Baxter Aktiengesellschaft | Fibrin/fibrinogen binding conjugate |
ES2321068T3 (es) | 2001-04-25 | 2009-06-02 | Eidgenossische Technische Hochschule Zurich | Matrices de suministro de farmacos para mejorar la curacion de heridas. |
NL1017994C2 (nl) * | 2001-05-04 | 2002-11-05 | Tno | Hechting van vlees- en visproducten. |
JP2002369877A (ja) * | 2001-06-14 | 2002-12-24 | Japan Science & Technology Corp | 神経再建生体材料およびその製造方法 |
IL144446A0 (en) * | 2001-07-19 | 2002-05-23 | Prochon Biotech Ltd | Plasma protein matrices and methods for their preparation |
US8815793B2 (en) | 2001-07-20 | 2014-08-26 | Northwestern University | Polymeric compositions and related methods of use |
US7858679B2 (en) | 2001-07-20 | 2010-12-28 | Northwestern University | Polymeric compositions and related methods of use |
US7618937B2 (en) | 2001-07-20 | 2009-11-17 | Northwestern University | Peptidomimetic polymers for antifouling surfaces |
JP2003126125A (ja) * | 2001-10-24 | 2003-05-07 | Katsuko Sakai | 人工血管及びその製造方法 |
FI20012082A0 (fi) | 2001-10-26 | 2001-10-26 | Paeivi Liesi | Biologisesti aktiiviset peptidit hermovauroiden korjaamiseksi |
CA2468187A1 (en) * | 2001-11-28 | 2003-06-05 | Becton, Dickinson And Company | Peptides with growth inhibitory action |
EP1864681A1 (de) | 2001-12-18 | 2007-12-12 | Eidgenössische Technische Hochschule Zürich | Wachstumsfaktormodifizierte Proteinmatrizes zur Geweberekonstruktion |
US7247609B2 (en) | 2001-12-18 | 2007-07-24 | Universitat Zurich | Growth factor modified protein matrices for tissue engineering |
AU2003215280A1 (en) | 2002-02-15 | 2003-09-09 | Northwestern University | Self-assembly of peptide-amphiphile nanofibers under physiological conditions |
US8911831B2 (en) | 2002-07-19 | 2014-12-16 | Northwestern University | Surface independent, surface-modifying, multifunctional coatings and applications thereof |
WO2004016167A1 (en) * | 2002-08-16 | 2004-02-26 | The General Hospital Corporation | Non-invasive functional imaging of peripheral nervous system activation in humans and animals |
US20060140914A1 (en) * | 2002-10-31 | 2006-06-29 | The General Hospital Corporation | Repairing or replacing tissues or organs |
WO2004042068A2 (en) * | 2002-10-31 | 2004-05-21 | Northwestern University | Injectable and bioadhesive polymeric hydrogels as well as related methods of enzymatic preparation |
US7554021B2 (en) | 2002-11-12 | 2009-06-30 | Northwestern University | Composition and method for self-assembly and mineralization of peptide amphiphiles |
US7067123B2 (en) | 2003-04-29 | 2006-06-27 | Musculoskeletal Transplant Foundation | Glue for cartilage repair |
US7901457B2 (en) | 2003-05-16 | 2011-03-08 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
US20080050812A1 (en) * | 2003-05-30 | 2008-02-28 | Cox James W | Micropositioning Cells For Tissue Engineering |
CA2527728A1 (en) | 2003-05-30 | 2004-12-16 | Board Of Regents, The University Of Texas System | Micropositioning cells for tissue engineering |
KR20060032140A (ko) * | 2003-05-30 | 2006-04-14 | 센토코 인코포레이티드 | 트랜스글루타미나아제를 이용한 신규 에리트로포이에틴접합체의 형성 |
US7338517B2 (en) | 2003-06-04 | 2008-03-04 | University Of South Carolina | Tissue scaffold having aligned fibrils and artificial tissue comprising the same |
CN102225964A (zh) | 2003-12-05 | 2011-10-26 | 西北大学 | 自组装的肽两亲物和用于生长因子传递的相关方法 |
WO2005072764A2 (en) * | 2004-01-16 | 2005-08-11 | Novocell, Inc. | Fibrin-bound angiogenic factors to stimulate vascularization of transplant site of encapsulated cells |
ES2293753B1 (es) * | 2004-04-28 | 2009-03-16 | Lipotec, S.A. | Uso de peptidos xikvav en preparacion de composiciones cosmeticas para mejorar la firmeza de la piel mediante el aumento de la adhesion celular. |
US20090319045A1 (en) | 2004-10-12 | 2009-12-24 | Truncale Katherine G | Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles |
US7837740B2 (en) | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
WO2006050213A2 (en) * | 2004-10-29 | 2006-05-11 | Michalow Alexander E | Methods of promoting healing of cartilage defects and method of causing stem cells to differentiate by the articular chondrocyte pathway |
KR101206345B1 (ko) | 2004-12-10 | 2012-12-06 | 스트라우만 홀딩 에이쥐 | 신규한 단백질 배합물 |
MX2007007732A (es) * | 2004-12-22 | 2007-10-08 | Kuros Biosurgery Ag | Hidrogeles peg con grupos funcionales para la reaccion de adicion tipo michael con biofactores incorporados con el factor xiiia. |
WO2006073711A2 (en) * | 2005-01-06 | 2006-07-13 | Kuros Biosurgery Ag | Use of a matrix comprising a contrast agent in soft tissues |
BRPI0606409A2 (pt) | 2005-01-06 | 2009-06-23 | Kuros Biosurgery Ag | matrizes suplementadas para o reparo de fraturas ósseas |
US8575101B2 (en) | 2005-01-06 | 2013-11-05 | Kuros Biosurgery Ag | Supplemented matrices for the repair of bone fractures |
US7815926B2 (en) | 2005-07-11 | 2010-10-19 | Musculoskeletal Transplant Foundation | Implant for articular cartilage repair |
EP1926459B1 (de) | 2005-09-19 | 2015-01-07 | Histogenics Corporation | Zellunterstützende matrix mit eng definierter, gleichmässig senkrecht und nicht zufällig organisierter porosität und porendichte und verfahren zur herstellung davon |
US7732539B2 (en) | 2006-02-16 | 2010-06-08 | National Science Foundation | Modified acrylic block copolymers for hydrogels and pressure sensitive wet adhesives |
US8865869B2 (en) * | 2006-03-20 | 2014-10-21 | Worcester Polytechnic Institute | Collagen and fibrin microthreads in a discrete thread model of in vitro ACL scaffold regeneration |
EP2064251B1 (de) | 2006-08-04 | 2017-10-25 | Kensey Nash Corporation | Biomimetische verbindungen und syntheseverfahren dafür |
US8563117B2 (en) | 2006-08-04 | 2013-10-22 | Phillip B. Messersmith | Biomimetic modular adhesive complex: materials, methods and applications therefore |
EP2111239B1 (de) | 2006-12-15 | 2013-03-06 | Lifebond Ltd. | Hämostatische gelatin-transglutaminase-verbände und dichtungsstoffe |
US8673286B2 (en) | 2007-04-09 | 2014-03-18 | Northwestern University | DOPA-functionalized, branched, poly(aklylene oxide) adhesives |
US8383092B2 (en) * | 2007-02-16 | 2013-02-26 | Knc Ner Acquisition Sub, Inc. | Bioadhesive constructs |
US8435551B2 (en) | 2007-03-06 | 2013-05-07 | Musculoskeletal Transplant Foundation | Cancellous construct with support ring for repair of osteochondral defects |
DK2136850T3 (da) | 2007-04-13 | 2012-04-10 | Kuros Biosurgery Ag | Polymervævforsegling |
US8076295B2 (en) * | 2007-04-17 | 2011-12-13 | Nanotope, Inc. | Peptide amphiphiles having improved solubility and methods of using same |
JP4966084B2 (ja) | 2007-04-25 | 2012-07-04 | エスアイアイ・プリンテック株式会社 | インクジェットヘッドの駆動方法、インクジェットヘッドおよびインクジェット記録装置 |
WO2009033774A2 (en) * | 2007-09-11 | 2009-03-19 | Mondobiotech Laboratories Ag | Use of a laminin nonapeptide as a therapeutic agent |
JP2011511651A (ja) * | 2007-10-12 | 2011-04-14 | クロス・バイオサージェリー・アクチェンゲゼルシャフト | 組織増強のための注入可能な放射線不透過組成物 |
JP2012512812A (ja) | 2007-12-28 | 2012-06-07 | クロス・バイオサージェリー・アクチェンゲゼルシャフト | フィブリンフォームに組込まれたpdgf融合タンパク質 |
CA2721477A1 (en) * | 2008-04-18 | 2009-12-03 | Kuros Biosurgery Ag | Dispensing device, kit containing the device, and method of operating the device |
CN102124058B (zh) | 2008-06-18 | 2014-05-28 | 生命连结有限公司 | 改进的交联组合物 |
EP2419116A1 (de) | 2009-04-13 | 2012-02-22 | North Western University | Neue peptidbasierte gerüste für knorpelregenerierung und anwendungsverfahren dafür |
US20100316764A1 (en) * | 2009-06-10 | 2010-12-16 | Engrain, LLC | Flour supplement compositions and methods for preparing wheat flour |
AU2010334412B2 (en) | 2009-12-22 | 2016-02-04 | Lifebond Ltd | Modification of enzymatic crosslinkers for controlling properties of crosslinked matrices |
WO2011100460A2 (en) * | 2010-02-11 | 2011-08-18 | Ecole Polytechnique Federale De Lausanne | Ccr7 ligand delivery and co-delivery in immunotherapy |
ITPD20100155A1 (it) | 2010-05-19 | 2011-11-20 | Univ Padova | Metodo per la preparazione di coniugati mediante transglutaminasi |
AU2011287215B2 (en) | 2010-08-05 | 2015-09-10 | Lifebond Ltd. | Dry composition wound dressings and adhesives |
US9320826B2 (en) | 2010-11-09 | 2016-04-26 | Kensey Nash Corporation | Adhesive compounds and methods use for hernia repair |
EP2686027B1 (de) | 2011-03-16 | 2021-05-05 | Kuros Biosurgery AG | Pharmazeutische formulierung zur verwendung für die wirbelsäulenfusion |
US20150104427A1 (en) * | 2011-11-10 | 2015-04-16 | The Regents Of The University Of California | Enzyme-assisted spatial decoration of biomaterials |
US9879062B2 (en) | 2012-07-03 | 2018-01-30 | Ecole Polytechnique Federale De Lausanne | Protein-binding peptide isolated from placenta growth factor |
US9540428B2 (en) | 2012-07-03 | 2017-01-10 | Ecole Polytechnique Federale De Lausanne (Epfl) | Extracellular matrix heparin-binding domains |
US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
US10322206B2 (en) | 2016-03-29 | 2019-06-18 | Worcester Polytechnic Institute | Compositions and methods for wound healing |
EP3453722A1 (de) * | 2017-09-06 | 2019-03-13 | Julius-Maximilians-Universität Würzburg | Pharmazeutika und vorrichtungen für kovalente immobilisierung an der extrazellulären matrix durch transglutaminase |
EP3710466A2 (de) | 2017-11-13 | 2020-09-23 | The University of Chicago | Verfahren und zusammensetzungen zur behandlung von wunden |
EP3569614A1 (de) * | 2018-05-18 | 2019-11-20 | Julius-Maximilians-Universität Würzburg | Verbindungen und verfahren zur immobilisierung von myostatin-inhibitoren auf der extrazellulären matrix durch transglutaminase |
US11998654B2 (en) | 2018-07-12 | 2024-06-04 | Bard Shannon Limited | Securing implants and medical devices |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE8200751L (sv) | 1982-02-09 | 1983-08-10 | Olle Larm | Forfarande for kovalent koppling for framstellning av konjugat och hervid erhallna produkter |
ATE185376T1 (de) | 1987-07-06 | 1999-10-15 | Biopool Int Inc | Verfahren zur messung von gewebeplasminogenaktivator, antithrombin-iii und lösliches fibrin |
EP0325639A4 (en) * | 1987-07-07 | 1990-10-24 | Cytrx Biopool Ltd. | Fibrin-binding compound and method |
US5504001A (en) * | 1987-11-25 | 1996-04-02 | Zymogenetics, Inc. | Hybrid plasminogen activator |
US5100668A (en) | 1988-06-14 | 1992-03-31 | Massachusetts Institute Of Technology | Controlled release systems containing heparin and growth factors |
EP0406357B1 (de) * | 1988-11-09 | 1998-01-07 | Protein Polymer Technologies, Inc. | Funktionelles, durch ein rekombinantes verfahren hergestelltes synthetisches proteinpolymer |
SE9101853D0 (sv) * | 1991-06-17 | 1991-06-17 | Jonas Wadstroem | Improved tissue ashesive |
US5428014A (en) * | 1993-08-13 | 1995-06-27 | Zymogenetics, Inc. | Transglutaminase cross-linkable polypeptides and methods relating thereto |
US5773577A (en) * | 1994-03-03 | 1998-06-30 | Protein Polymer Technologies | Products comprising substrates capable of enzymatic cross-linking |
US5693341A (en) | 1995-03-16 | 1997-12-02 | Collagen Corporation | Affinity bound collagen matrices for the delivery of biologically active agents |
US5561982A (en) | 1995-05-02 | 1996-10-08 | Universal Vortex, Inc. | Method for energy separation and utilization in a vortex tube which operates with pressure not exceeding atmospheric pressure |
US5958874A (en) * | 1998-02-18 | 1999-09-28 | The Research Foundation Of State University Of New York | Recombinant fibronectin-based extracellular matrix for wound healing |
-
1998
- 1998-04-02 EP EP98919729A patent/EP1124590B1/de not_active Expired - Lifetime
- 1998-04-02 GB GB0009882A patent/GB2348426B/en not_active Expired - Fee Related
- 1998-04-02 CA CA2307954A patent/CA2307954C/en not_active Expired - Lifetime
- 1998-04-02 DE DE19882746T patent/DE19882746T1/de not_active Withdrawn
- 1998-04-02 WO PCT/US1998/006617 patent/WO1998043686A1/en active Application Filing
- 1998-04-02 AU AU72455/98A patent/AU7245598A/en not_active Abandoned
- 1998-04-08 US US09/057,052 patent/US6331422B1/en not_active Expired - Lifetime
-
2000
- 2000-10-24 US US09/695,466 patent/US6607740B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US6607740B1 (en) | 2003-08-19 |
EP1124590A1 (de) | 2001-08-22 |
GB2348426A (en) | 2000-10-04 |
CA2307954C (en) | 2010-07-13 |
GB0009882D0 (en) | 2000-06-07 |
WO1998043686A1 (en) | 1998-10-08 |
GB2348426B (en) | 2001-06-27 |
AU7245598A (en) | 1998-10-22 |
EP1124590B1 (de) | 2009-06-17 |
CA2307954A1 (en) | 1998-10-08 |
US6331422B1 (en) | 2001-12-18 |
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