DE156243T1 - Mittel mit gesteuerter freisetzung sowie dessen herstellung. - Google Patents

Mittel mit gesteuerter freisetzung sowie dessen herstellung.

Info

Publication number
DE156243T1
DE156243T1 DE198585102826T DE85102826T DE156243T1 DE 156243 T1 DE156243 T1 DE 156243T1 DE 198585102826 T DE198585102826 T DE 198585102826T DE 85102826 T DE85102826 T DE 85102826T DE 156243 T1 DE156243 T1 DE 156243T1
Authority
DE
Germany
Prior art keywords
isopropylpyrazolo
isobutyryl
preparation
pyridine
controlled release
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE198585102826T
Other languages
English (en)
Inventor
Jun Yokohama-Shi Kanagawa-Ken Imai
Tsutomu Nerima-Ku Tokyo Irikura
Masakatsu Shimotsuga-Gun Tochigi-Ken Komuro
Hiroshi Urawa-Shi Saitama-Ken Uchida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyorin Pharmaceutical Co Ltd
Original Assignee
Kyorin Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Pharmaceutical Co Ltd filed Critical Kyorin Pharmaceutical Co Ltd
Publication of DE156243T1 publication Critical patent/DE156243T1/de
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Claims (7)

PATENTANWÄLTE EUROPEAN PATENT ATTORNEYS u.Z.: T 621 EP EP 85 10 2826.6 KYORIN SEIYAKU KABUSHIKI KAISHA Deutsche Übersetzung der Patentansprüche nach Artikel 67(1) EPÜ 10 Patentansprüche:
1. Arzneimittel mit gesteuerter Wirkstoffabgabe von 3-Isobutyryl^-isopropylpyrazolo/f^-a/pyridin.
2. Arzneimittel nach Anspruch 1, in dem die Zubereitung mit gesteuerter Wirkstoffabgabe in Form eines Pulvers oder Granulates vorliegt, das 3-Isobutyryl-2-isopropylpyrazolo/'T^-a/pyridin enthält, beschichtet mit einem medizinisch nicht wirksamen Stoff.
3. Arzneimittel nach Anspruch 1, in dem 3-Isobutyryl-2-isopropylpyrazolo^T^-aZpyridin in Fettstoffe implantiert ist.
4. Arzneimittel nach Anspruch 1, in dem die Zubereitung mit gesteuerter Wirkstoffabgabe in Form eines 3-Isobutyryl-2-isopropylpyrazolo^T,5-a7pyridin enthaltenden rektal zu gebenden Suppositoriums vorliegt.
5. Verfahren zur Herstellung einer Zubereitung mit gesteuerter Wirkstoffabgabe nach Anspruch 1, umfassend die Granulierung von 3-Isobutyryl-2-isopropylpyrazolo-/T,5-a7pyridin und Beschichtung der erhaltenen Teilchen mit einem medizinisch nicht wirksamen Stoff.
L J
1
6. Verfahren zur Herstellung des Präparates mit gesteuerter Wirkstoffabgabe nach Anspruch 1, umfäsend die Implantierung von 3-Isobutyryl-2-isopropylpyrazolo^,5-a7-pyridin in Fettstoffe. 5
7. Verfahren zur Herstellung des Präparates mit gesteuerter Wirkstoffabgabe nach Anspruch 1, umfassend die Implantierung von 3-Isobutyryl-2-isopropylpyrazolo/T,5-§7-pyridin in ein rektal zu verabreichendes Suppositorium. 10
L J
DE198585102826T 1984-03-14 1985-03-12 Mittel mit gesteuerter freisetzung sowie dessen herstellung. Pending DE156243T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59048441A JPH0621066B2 (ja) 1984-03-14 1984-03-14 ３―イソブチリル―２―イソプロピルピラゾロ〔１，５―ａ〕ピリジンの徐放性医薬品組成物

Publications (1)

Publication Number Publication Date
DE156243T1 true DE156243T1 (de) 1986-05-22

Family

ID=12803438

Family Applications (2)

Application Number Title Priority Date Filing Date
DE8585102826T Expired - Lifetime DE3580774D1 (de) 1984-03-14 1985-03-12 Mittel mit gesteuerter freisetzung sowie dessen herstellung.
DE198585102826T Pending DE156243T1 (de) 1984-03-14 1985-03-12 Mittel mit gesteuerter freisetzung sowie dessen herstellung.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE8585102826T Expired - Lifetime DE3580774D1 (de) 1984-03-14 1985-03-12 Mittel mit gesteuerter freisetzung sowie dessen herstellung.

Country Status (11)

Country Link
US (1) US5151434A (de)
EP (2) EP0156243B1 (de)
JP (1) JPH0621066B2 (de)
KR (1) KR850006130A (de)
AU (1) AU582739B2 (de)
DE (2) DE3580774D1 (de)
DK (2) DK169421B1 (de)
IE (1) IE57853B1 (de)
NZ (1) NZ211424A (de)
PH (1) PH21996A (de)
ZA (1) ZA851830B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6263520A (ja) * 1985-09-14 1987-03-20 Kyorin Pharmaceut Co Ltd 抗リウマチ剤
JPH01153633A (ja) 1987-12-10 1989-06-15 Kyorin Pharmaceut Co Ltd 経皮吸収製剤
JPH01153634A (ja) * 1987-12-10 1989-06-15 Kyorin Pharmaceut Co Ltd 吸入剤
US5213800A (en) * 1989-02-09 1993-05-25 Diamond Scientific Company Chlorhexidine disinfectant granules
JPH0674206B2 (ja) * 1989-12-28 1994-09-21 田辺製薬株式会社 放出制御型製剤およびその製法
JP2558396B2 (ja) * 1990-06-28 1996-11-27 田辺製薬株式会社 放出制御型製剤
US6548084B2 (en) * 1995-07-20 2003-04-15 Smithkline Beecham Plc Controlled release compositions
US8293277B2 (en) 1998-10-01 2012-10-23 Alkermes Pharma Ireland Limited Controlled-release nanoparticulate compositions
WO2000018374A1 (en) * 1998-10-01 2000-04-06 Elan Pharma International, Ltd. Controlled release nanoparticulate compositions
US8236352B2 (en) 1998-10-01 2012-08-07 Alkermes Pharma Ireland Limited Glipizide compositions
US7198795B2 (en) 2000-09-21 2007-04-03 Elan Pharma International Ltd. In vitro methods for evaluating the in vivo effectiveness of dosage forms of microparticulate of nanoparticulate active agent compositions
US6720356B2 (en) * 2001-04-20 2004-04-13 Spencer Feldman Magnesium di-potassium EDTA complex and method of administration
JP4598399B2 (ja) 2002-02-04 2010-12-15 エラン ファーマ インターナショナル，リミティド 表面安定剤としてリゾチームを有するナノ粒子組成物
FR2891459B1 (fr) * 2005-09-30 2007-12-28 Flamel Technologies Sa Microparticules a liberation modifiee d'au moins un principe actif et forme galenique orale en comprenant
JP5352452B2 (ja) * 2006-06-06 2013-11-27 メディシノバ， インコーポレイテッド 置換ピラゾロ［１，５−ａ］ピリジン化合物およびその使用方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3784683A (en) * 1971-03-29 1974-01-08 Abbott Lab Tablet preparation
JPS5229318B2 (de) * 1972-03-30 1977-08-01
JPS5229318A (en) * 1975-09-01 1977-03-05 Nippon Telegraph & Telephone Type head for high speed printer or the like
CA1188505A (en) * 1982-08-24 1985-06-11 Kenneth L. Hurley Toner feeder system
US4540566A (en) * 1984-04-02 1985-09-10 Forest Laboratories, Inc. Prolonged release drug dosage forms based on modified low viscosity grade hydroxypropylmethylcellulose
JPS6263520A (ja) * 1985-09-14 1987-03-20 Kyorin Pharmaceut Co Ltd 抗リウマチ剤

Also Published As

Publication number Publication date
AU582739B2 (en) 1989-04-13
EP0156243B1 (de) 1990-12-05
EP0156243A2 (de) 1985-10-02
DK57993A (da) 1993-05-18
EP0156243A3 (en) 1987-03-25
KR850006130A (ko) 1985-10-02
JPH0621066B2 (ja) 1994-03-23
DK169421B1 (da) 1994-10-31
DK169096B1 (da) 1994-08-15
EP0375662A2 (de) 1990-06-27
US5151434A (en) 1992-09-29
IE850593L (en) 1985-09-14
DK106685A (da) 1985-09-15
PH21996A (en) 1988-05-02
ZA851830B (en) 1985-11-27
DK106685D0 (da) 1985-03-08
NZ211424A (en) 1988-09-29
DE3580774D1 (de) 1991-01-17
DK57993D0 (da) 1993-05-18
EP0375662A3 (de) 1990-11-07
IE57853B1 (en) 1993-04-21
AU3967685A (en) 1985-09-19
JPS60193913A (ja) 1985-10-02

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