DE1095076T1 - Ineinandergreifendes polymernetzwerk aus hydrophilen hydrogelen für kontaktlinsen - Google Patents
Ineinandergreifendes polymernetzwerk aus hydrophilen hydrogelen für kontaktlinsenInfo
- Publication number
- DE1095076T1 DE1095076T1 DE1095076T DE99933826T DE1095076T1 DE 1095076 T1 DE1095076 T1 DE 1095076T1 DE 1095076 T DE1095076 T DE 1095076T DE 99933826 T DE99933826 T DE 99933826T DE 1095076 T1 DE1095076 T1 DE 1095076T1
- Authority
- DE
- Germany
- Prior art keywords
- polymer
- hydrogel composition
- group
- methacrylate
- dry weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920000642 polymer Polymers 0.000 title claims 20
- 239000000017 hydrogel Substances 0.000 title claims 16
- 239000000203 mixture Substances 0.000 claims 15
- 239000000178 monomer Substances 0.000 claims 6
- 239000003431 cross linking reagent Substances 0.000 claims 5
- -1 dimethyldiphenylmethylvinylsiloxane Chemical class 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 4
- 150000003462 sulfoxides Chemical class 0.000 claims 4
- NYEZZYQZRQDLEH-UHFFFAOYSA-N 2-ethyl-4,5-dihydro-1,3-oxazole Chemical compound CCC1=NCCO1 NYEZZYQZRQDLEH-UHFFFAOYSA-N 0.000 claims 2
- SOGAXMICEFXMKE-UHFFFAOYSA-N Butylmethacrylate Chemical compound CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 claims 2
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims 2
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 2
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Chemical compound CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 claims 2
- GYDSPAVLTMAXHT-UHFFFAOYSA-N pentyl 2-methylprop-2-enoate Chemical compound CCCCCOC(=O)C(C)=C GYDSPAVLTMAXHT-UHFFFAOYSA-N 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 229920002554 vinyl polymer Polymers 0.000 claims 2
- OSSNTDFYBPYIEC-UHFFFAOYSA-N 1-ethenylimidazole Chemical compound C=CN1C=CN=C1 OSSNTDFYBPYIEC-UHFFFAOYSA-N 0.000 claims 1
- XXVUSJBWYAWVQV-UHFFFAOYSA-N 1-ethenylpiperidine-2,6-dione Chemical compound C=CN1C(=O)CCCC1=O XXVUSJBWYAWVQV-UHFFFAOYSA-N 0.000 claims 1
- VOCDJQSAMZARGX-UHFFFAOYSA-N 1-ethenylpyrrolidine-2,5-dione Chemical compound C=CN1C(=O)CCC1=O VOCDJQSAMZARGX-UHFFFAOYSA-N 0.000 claims 1
- ZSZRUEAFVQITHH-UHFFFAOYSA-N 2-(2-methylprop-2-enoyloxy)ethyl 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CC(=C)C(=O)OCCOP([O-])(=O)OCC[N+](C)(C)C ZSZRUEAFVQITHH-UHFFFAOYSA-N 0.000 claims 1
- SFPNZPQIIAJXGL-UHFFFAOYSA-N 2-ethoxyethyl 2-methylprop-2-enoate Chemical compound CCOCCOC(=O)C(C)=C SFPNZPQIIAJXGL-UHFFFAOYSA-N 0.000 claims 1
- IEVADDDOVGMCSI-UHFFFAOYSA-N 2-hydroxybutyl 2-methylprop-2-enoate Chemical compound CCC(O)COC(=O)C(C)=C IEVADDDOVGMCSI-UHFFFAOYSA-N 0.000 claims 1
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 claims 1
- GNSFRPWPOGYVLO-UHFFFAOYSA-N 3-hydroxypropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCCO GNSFRPWPOGYVLO-UHFFFAOYSA-N 0.000 claims 1
- DBCAQXHNJOFNGC-UHFFFAOYSA-N 4-bromo-1,1,1-trifluorobutane Chemical compound FC(F)(F)CCCBr DBCAQXHNJOFNGC-UHFFFAOYSA-N 0.000 claims 1
- OVTLUDLKKUSJCU-UHFFFAOYSA-N 4-carboxyoxybut-3-enyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCC=COC(=O)O OVTLUDLKKUSJCU-UHFFFAOYSA-N 0.000 claims 1
- MSRJEBGZJWLQOC-UHFFFAOYSA-N 4-ethenyl-5-methylmorpholin-3-one Chemical compound CC1COCC(=O)N1C=C MSRJEBGZJWLQOC-UHFFFAOYSA-N 0.000 claims 1
- KFDVPJUYSDEJTH-UHFFFAOYSA-N 4-ethenylpyridine Chemical compound C=CC1=CC=NC=C1 KFDVPJUYSDEJTH-UHFFFAOYSA-N 0.000 claims 1
- VJOWMORERYNYON-UHFFFAOYSA-N 5-ethenyl-2-methylpyridine Chemical compound CC1=CC=C(C=C)C=N1 VJOWMORERYNYON-UHFFFAOYSA-N 0.000 claims 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 1
- 102100026735 Coagulation factor VIII Human genes 0.000 claims 1
- GDFCSMCGLZFNFY-UHFFFAOYSA-N Dimethylaminopropyl Methacrylamide Chemical compound CN(C)CCCNC(=O)C(C)=C GDFCSMCGLZFNFY-UHFFFAOYSA-N 0.000 claims 1
- IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical compound OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 claims 1
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 claims 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 1
- 125000000815 N-oxide group Chemical group 0.000 claims 1
- HQCFGIFFVCFWGT-UHFFFAOYSA-N OC(=O)C(C)=CC1CCC(C(C)(C)C)CC1O Chemical compound OC(=O)C(C)=CC1CCC(C(C)(C)C)CC1O HQCFGIFFVCFWGT-UHFFFAOYSA-N 0.000 claims 1
- OKKRPWIIYQTPQF-UHFFFAOYSA-N Trimethylolpropane trimethacrylate Chemical compound CC(=C)C(=O)OCC(CC)(COC(=O)C(C)=C)COC(=O)C(C)=C OKKRPWIIYQTPQF-UHFFFAOYSA-N 0.000 claims 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims 1
- 239000011358 absorbing material Substances 0.000 claims 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 claims 1
- 230000002421 anti-septic effect Effects 0.000 claims 1
- 229940064004 antiseptic throat preparations Drugs 0.000 claims 1
- CQEYYJKEWSMYFG-UHFFFAOYSA-N butyl acrylate Chemical compound CCCCOC(=O)C=C CQEYYJKEWSMYFG-UHFFFAOYSA-N 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 239000003086 colorant Substances 0.000 claims 1
- 125000001303 disiloxanyl group Chemical group [H][Si]([*])([H])O[Si]([H])([H])[H] 0.000 claims 1
- UIWXSTHGICQLQT-UHFFFAOYSA-N ethenyl propanoate Chemical compound CCC(=O)OC=C UIWXSTHGICQLQT-UHFFFAOYSA-N 0.000 claims 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims 1
- 150000002734 metacrylic acid derivatives Chemical class 0.000 claims 1
- VOAWOIGCXMLYFY-UHFFFAOYSA-N n-(2-oxoethyl)prop-2-enamide Chemical compound C=CC(=O)NCC=O VOAWOIGCXMLYFY-UHFFFAOYSA-N 0.000 claims 1
- OCMFIRSRLNISHF-UHFFFAOYSA-N n-[4-(dimethylamino)-2-methylbutan-2-yl]prop-2-enamide Chemical compound CN(C)CCC(C)(C)NC(=O)C=C OCMFIRSRLNISHF-UHFFFAOYSA-N 0.000 claims 1
- YPHQUSNPXDGUHL-UHFFFAOYSA-N n-methylprop-2-enamide Chemical compound CNC(=O)C=C YPHQUSNPXDGUHL-UHFFFAOYSA-N 0.000 claims 1
- ULDDEWDFUNBUCM-UHFFFAOYSA-N pentyl prop-2-enoate Chemical compound CCCCCOC(=O)C=C ULDDEWDFUNBUCM-UHFFFAOYSA-N 0.000 claims 1
- 239000003505 polymerization initiator Substances 0.000 claims 1
- NHARPDSAXCBDDR-UHFFFAOYSA-N propyl 2-methylprop-2-enoate Chemical compound CCCOC(=O)C(C)=C NHARPDSAXCBDDR-UHFFFAOYSA-N 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- PNXMTCDJUBJHQJ-UHFFFAOYSA-N propyl prop-2-enoate Chemical compound CCCOC(=O)C=C PNXMTCDJUBJHQJ-UHFFFAOYSA-N 0.000 claims 1
- 229920001567 vinyl ester resin Polymers 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F291/00—Macromolecular compounds obtained by polymerising monomers on to macromolecular compounds according to more than one of the groups C08F251/00 - C08F289/00
- C08F291/18—Macromolecular compounds obtained by polymerising monomers on to macromolecular compounds according to more than one of the groups C08F251/00 - C08F289/00 on to irradiated or oxidised macromolecules
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F265/00—Macromolecular compounds obtained by polymerising monomers on to polymers of unsaturated monocarboxylic acids or derivatives thereof as defined in group C08F20/00
- C08F265/04—Macromolecular compounds obtained by polymerising monomers on to polymers of unsaturated monocarboxylic acids or derivatives thereof as defined in group C08F20/00 on to polymers of esters
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F271/00—Macromolecular compounds obtained by polymerising monomers on to polymers of nitrogen-containing monomers as defined in group C08F26/00
- C08F271/02—Macromolecular compounds obtained by polymerising monomers on to polymers of nitrogen-containing monomers as defined in group C08F26/00 on to polymers of monomers containing heterocyclic nitrogen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F283/00—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F283/00—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G
- C08F283/12—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G on to polysiloxanes
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
- G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
- G02B1/041—Lenses
- G02B1/043—Contact lenses
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Eyeglasses (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Claims (14)
- • · · ■···■#DE/EP 1 095 076 T1Anmeldungs-Nr. 99 933 826.2 UBVeröffentlichungs-Nr.Patentansprüche
1. Hydrogel-Zusammensetzung, umfassend:I. Wenigstens ein Polymer undII. wenigstens ein Mittel zur Erzeugung eines interpenetrierenden Polymernetzwerkes, das das wenigstens eine Polymer interpenetriert, ausgewählt aus der Gruppe bestehend aus:(A) wenigstens einem Polymer, umfassend eine oder mehrere Monomereinheiten, die wenigstens eine =N-C(=O)—Gruppe umfassen;(B) wenigstens einem Polymer, umfassend eine oder mehrere Einheiten, die wenigstens eine IM-Oxid-Gruppe umfassen;(C) wenigstens einem Polymer, das sowohl =N-C(=O)—Gruppen als auch N-Oxid-Gruppen von (A) und (B) umfasst, und(D) Mischungen davon undIII. gegebenenfalls wenigstens ein Material, das aus der aus Monomeren, polymeren Vernetzungsmitteln, Polymerisationsinitiatoren, Ultraviolett absorbierenden Materialien, farbgebenden Mitteln, Antiseptika bestehenden Gruppe und Kombinationen davon ausgewählt ist.VEfEP T 095076 Tl - 2. Hydrogel-Zusammensetzung nach Anspruch 1, wobei das wenigstens eine Polymer wenigstens ein Polymer umfasst, das wenigstens ein Monomer umfasst, das ausgewählt ist aus der Gruppe bestehend aus: 2-Hydroxyethylmethacrylat, 2-Hydroxyethylacrylat, Methylmethacrylat; Methylacrylamid; Methacrylamid; &Ngr;,&Ngr;-Dimethyldiacetonacrylamid; 2-Phosphatoethylmethacrylat; Di-, Tri-, Tetra-, Penta-, ... Polyethylenglycolmonoacrylat und -Methacrylat; 4- und 2-Methyl-5-vinylpyridin; N-(3-methacrylamidopropyl)-N,N-dimethylamin; N-(3-methacrYlamidopropyl)-N,N,N-trimethylamin; 1-Vinyl- und 2-Methyl-l-vinylmidazol; N-(3-acrylamido-3-methylbutyl)-N,N-dimethylamin; N-Methylacrylamid; 3-Hydroxypropylmethacrylat; N-Vinylimidazol; N-Vinylsuccinimid; N-Vinyldiglycolylimid; N-Vinylglutarimid; N-Vinyl-3-morphoIinon; N-Vinyl-5-methyl-3-morpholinon; Propylmethacrylat; Propylacrylat; Butylmethacrylat; Butylacrylat; Pentylacrylat; Pentylmethacrylat; Dimethyldiphenylmethylvinylsiloxan; N-(I7I-dimethyl-3-oxobutyl)acrylamid; 2-Ethyl-2-(hydroxymethyl)-l,3-propandioltrimethacrylat; X-(Dimethylvinylsilyl)-(d-[(dimethylvinylsilyl)oxy]-dimethyldiphenylmethylvinylsiloxan; Butyl(meth)acrylat; 2-Hydroxybutylmethacrylat; Vinylacetat; Pentyl methacrylat; Vinylpropionat; 3-Hydroxy-2-naphthylmethacrylat; Vinylalkohol; N-(formylmethyl)acrylamid; 2-Ethoxyethylmethacrylat; 4-t-Butyl-2-hydroxycyclohexylmethacrylat; 2-(Methacryloyloxy)ethylvinylcarbonat; VinylCS-CS^^-trimethyl-l^-bisCtrimethylsiloxy)disiloxanyl]propyl]carbonat; 4,4'-(tetrapentacontmethylheptacosasiloxanylen)di-l-butanol; N-Carboxy-ß-alanin-N-vinylester; 2-Methacryloyloxyethylphosphorylcholin und Kombinationen davon.
- 3. Hydrogel-Zusammensetzung nach Anspruch 1, wobei das wenigstens eine Mittel zur Erzeugung eines interpenetrierenden Polymernetzwerkes etwa 1 %, bezogen auf die Trockenmasse, bis etwa 14 %, bezogen auf die Trockenmasse, und vorzugsweise etwa 5 %, bezogen auf die Trockenmasse, bis etwa 10 %, bezogen auf die Trockenmasse, der Hydrogel-Zusammensetzung umfasst."3" DE/EP 1 O95 O76 T1
- 4. Hydrogel-Zusammensetzung nach Anspruch 1, weiterhin umfassend wenigstens ein Sulfoxid enthaltendes Material, das aus der Gruppe bestehend aus Sulfoxid enthaltenden Methacrylaten, Sulfoxid enthaltenden Acrylaten und Kombinationen davon ausgewählt ist.
- 5. Hydrogel-Zusammensetzung nach Anspruch 1, wobei das wenigstens eine Mittel zur Erzeugung eines interpenetrierenden Polymernetzwerkes eine Molmasse umfasst, die höher als etwa 10 000 ist.
- 6. Hydrogel-Zusammensetzung nach Anspruch 1, wobei das polymere Vernetzungsmittel wenigstens eine Verbindung umfasst, die aus der aus wenigstens einem Monomer und wenigstens einem Polymer bestehenden Gruppe ausgewählt ist.
- 7. Hydrogel-Zusammensetzung nach Anspruch 6, wobei das wenigstens eine polymere Vernetzungsmittel ein Polymer mit einer Molmasse von etwa 300 bis etwa 1500 umfasst.
- 8. Hydrogel-Zusammensetzung nach Anspruch 6, wobei das wenigstens eine polymere Vernetzungsmittel etwa 0,1 %, bezogen auf die Trockenmasse, bis etwa 8 %, bezogen auf die Trockenmasse, und vorzugsweise etwa 0,5 %, bezogen auf die Trockenmasse, bis etwa 4 %, bezogen auf die Trockenmasse, des Hydrogels umfasst.
- 9. Hydrogel-Zusammensetzung nach Anspruch 6, wobei das polymere Vernetzungsmittel wenigstens eine Verbindung umfasst, die aus der aus Polyethylenglycoldimethacrylat und Ethylenglycoldimethacrlyat bestehenden Gruppe ausgewählt ist.
- 10. Hydrogel-Zusammensetzung nach Anspruch 1, wobei die optionalen Monomere wenigstens ein Monomer umfassen, das aus der aus Methylmethacrylat und N-Vinyllactamen bestehenden Gruppe ausgewählt ist.-«- DE/EP 1 O95 O78T1
- 11. Hydrogel-Zusammensetzung nach Anspruch 10, wobei das N-Vinyllactam N-Vinylpyrrolidon umfasst.
- 12. Hydrogel-Zusammensetzung nach Anspruch 1, wobei das Mittel zur Erzeugung eines interpenetrierenden Netzwerkes wenigstens ein Mittel umfasst, das aus der aus Polyvinylpyrrolidon, Polyvinylpyrrolidoniod, PoIy-2-ethyl-2-oxazolin und Poly(4-vinylpyridin-N-oxid) bestehenden Gruppe ausgewählt ist.
- 13. Interpenetrierendes Polymernetzwerk, umfassend wenigstens ein Polymer und wenigstens ein Mittel zur Erzeugung eines interpenetrierenden Polymernetzwerkes, das das wenigstens eine Polymer interpenetriert, wobei das interpenetrierende Polymernetzwerk einen Wasserverlust von weniger als etwa 5,0 Gew.-% nach 5 min bei etwa 75 % Feuchtigkeit und etwa 24 °C aufweist, wobei das wenigstens eine Polymer vorzugsweise wenigstens eine Verbindung umfasst, die aus der aus HEMA und MAA bestehenden Gruppe ausgewählt ist und das Mittel vorzugsweise wenigstens eine Verbindung umfasst, die aus der aus Polyvinylpyrrolidon, Polyvinylpyrrolidoniod, Poly-2-ethyl-2-oxazolin und Poly(4-vinylpyridin-N-oxid) bestehenden Gruppe ausgewählt ist.
- 14. Hydrogel-Zusammensetzung, umfassend ein Sulfoxid umfassendes, interpenetrierendes Polymemetzwerk.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9210098P | 1998-07-08 | 1998-07-08 | |
PCT/US1999/015532 WO2000002937A1 (en) | 1998-07-08 | 1999-07-08 | Interpenetrating polymer network hydrophilic hydrogels for contact lens |
Publications (1)
Publication Number | Publication Date |
---|---|
DE1095076T1 true DE1095076T1 (de) | 2002-04-04 |
Family
ID=22231556
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE1095076T Pending DE1095076T1 (de) | 1998-07-08 | 1999-07-08 | Ineinandergreifendes polymernetzwerk aus hydrophilen hydrogelen für kontaktlinsen |
Country Status (5)
Country | Link |
---|---|
US (2) | US20010044482A1 (de) |
EP (1) | EP1095076A4 (de) |
AU (1) | AU4980199A (de) |
DE (1) | DE1095076T1 (de) |
WO (1) | WO2000002937A1 (de) |
Families Citing this family (92)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070043140A1 (en) * | 1998-03-02 | 2007-02-22 | Lorenz Kathrine O | Method for the mitigation of symptoms of contact lens related dry eye |
US7052131B2 (en) | 2001-09-10 | 2006-05-30 | J&J Vision Care, Inc. | Biomedical devices containing internal wetting agents |
US6822016B2 (en) | 2001-09-10 | 2004-11-23 | Johnson & Johnson Vision Care, Inc. | Biomedical devices containing internal wetting agents |
WO2000002937A1 (en) | 1998-07-08 | 2000-01-20 | Sunsoft Corporation | Interpenetrating polymer network hydrophilic hydrogels for contact lens |
US6372815B1 (en) | 2000-04-18 | 2002-04-16 | Ocular Sciences Inc | Ophthalmic lenses and compositions, and methods for producing same |
JP2001316589A (ja) * | 2000-05-02 | 2001-11-16 | Dow Corning Corp | 相互貫入ポリマーネットワークを含んでなる組成物 |
US20030234459A1 (en) * | 2000-05-19 | 2003-12-25 | Nandu Mahendra P. | Method for the manufacture of molded polymeric devices using variable frequency microwaves |
WO2003093327A1 (fr) * | 2002-05-01 | 2003-11-13 | Hokkaido Technology Licensing Office Co., Ltd. | Gel ayant une structure multiple en réseau et procédé de production |
US7511083B2 (en) * | 2002-10-02 | 2009-03-31 | Coloplast A/S | Hydrogel |
WO2004097504A1 (en) | 2003-04-24 | 2004-11-11 | Ocular Sciences Inc. | Hydrogel contact lenses and package systems and production methods for same |
US8425926B2 (en) * | 2003-07-16 | 2013-04-23 | Yongxing Qiu | Antimicrobial medical devices |
EP1513358B1 (de) * | 2003-09-03 | 2007-03-07 | Research In Motion Limited | Verfahren und Vorrichtungen zur Anzeige eines Heimnetzwerknamens |
WO2006013612A1 (ja) * | 2004-06-18 | 2006-02-09 | Hokkaido Technology Licensing Office Co., Ltd. | 人工半月板 |
US7857447B2 (en) * | 2004-10-05 | 2010-12-28 | The Board Of Trustees Of The Leland Stanford Junior University | Interpenetrating polymer network hydrogel contact lenses |
US20090088846A1 (en) | 2007-04-17 | 2009-04-02 | David Myung | Hydrogel arthroplasty device |
US8821583B2 (en) * | 2004-10-05 | 2014-09-02 | The Board Of Trustees Of The Leland Stanford Junior University | Interpenetrating polymer network hydrogel |
US7909867B2 (en) * | 2004-10-05 | 2011-03-22 | The Board Of Trustees Of The Leland Stanford Junior University | Interpenetrating polymer network hydrogel corneal prosthesis |
US7857849B2 (en) * | 2004-10-05 | 2010-12-28 | The Board Of Trustees Of The Leland Stanford Junior Iniversity | Artificial corneal implant |
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US20050148682A1 (en) | 2005-07-07 |
AU4980199A (en) | 2000-02-01 |
EP1095076A4 (de) | 2002-11-06 |
US20010044482A1 (en) | 2001-11-22 |
EP1095076A1 (de) | 2001-05-02 |
US7279507B2 (en) | 2007-10-09 |
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