DD297970A5

DD297970A5 - PROCESS FOR THE PREPARATION OF BE1- (1H-INDOL-3-YL) -maleimide-DERIVATIVES AND THEIR USE

Info

Publication number: DD297970A5
Application number: DD90340398A
Authority: DD
Inventors: Hubert Barth; Johannes Hartenstein; Claus Rudolph; Christoph Schaechtele; Hans-Juergen Betche; Hartmut Osswald; Reinhard Reck
Original assignee: Goedecke Aktiengesellschaft,Wb
Priority date: 1989-05-05
Filing date: 1990-05-04
Publication date: 1992-01-30
Also published as: DE3914764A1; ZA903409B

Abstract

Die Erfindung betrifft Verfahren zur Herstellung von * der allgemeinen Formel * worin die verschiedenen Substituenten die in der Beschreibung angegebene Bedeutung haben. Die in analoger Weise zu bekannten Verfahren erfindungsgemaesz hergestellten Verbindungen eignen sich als Arzneimittel zur Praevention oder Behandlung von Herz- und Gefaeszkrankheiten, wie Thrombosen, Arteriosklerose, Hypertension, von Entzuendungsprozessen, Allergien, Krebs und bestimmten degenerativen Schaeden des Zentralnervensystems sowie von Krankheiten des Immunsystems und viralen Erkrankungen. Formel (I)The invention relates to processes for the preparation of the general formula wherein the various substituents have the meaning given in the description. The compounds prepared in an analogous manner to known processes according to the invention are suitable as medicaments for the prevention or treatment of cardiac and vascular diseases, such as thromboses, arteriosclerosis, hypertension, inflammatory processes, allergies, cancer and certain degenerative disorders of the central nervous system as well as diseases of the immune system and viral diseases. Formula (I)

Description

-i--i-

AP C 07 D/340 398 4 GÖDECKE AGAP C 07 D / 340 398 4 GÖDECKE AG

Verfahren zur Herstellung von Bis- (lH-indol-3-yl)maleinimid-Djerivaten und deren VerwendungProcess for the preparation of bis (1H-indol-3-yl) maleimide derivatives and their use

Anwendungsgebiet der ErfindungField of application of the invention

Die Erfindung betrifft ein Verfahren zur Herstellung von Bis-(lH-indol-3-yl)-maleinimid-Derivaten, die als Arzneimittel zur Prävention und/oder Behandlung von Herz- und Gefäßkrankheiten, wie Thrombosen, Arteriosklerose, Hypertonien, von Entzündungsprozessen, Allergien, Krebs und bestimmten degenerativen Schaden des Zentralnervensystems sowie von Krankheiten des Immunsystems und viralen Erkrankungen verwendet werden.The invention relates to a process for the preparation of bis (1H-indol-3-yl) -maleimide derivatives which are used as medicaments for the prevention and / or treatment of cardiovascular diseases such as thrombosis, arteriosclerosis, hypertension, inflammatory processes, allergies , Cancer and certain degenerative damage to the central nervous system, as well as from diseases of the immune system and viral diseases.

Charakteristik des bekannten Standes der Technik Veröffentlichungen, die der vorliegenden Erfindung als Stand der Technik zugrunde liegen, sind zur Zeit nicht bekannt. DESCRIPTION OF THE PRIOR ART Publications which underlie the present invention as a prior art are currently unknown.

Ziel der Erfindung _OI- Mit der vorliegenden Erfindung werden Verfahren zur Her-OBJECT OF THE INVENTION _OI - With the present invention, methods for producing

stellung neuer Bis-(lH-indol-3-yl)-maleinimid-Derivate bereitgestellt, die interessante pharmakologische Eigenschaften aufweisen. Insbesondere hemmen sie die Proteinkinase C, ein calcium- und phospholipidabhängigesprovided new bis (lH-indol-3-yl) -maleinimid derivatives which have interesting pharmacological properties. In particular, they inhibit protein kinase C, a calcium- and phospholipid-dependent

Schlüsselenzym, das bei der intrazellulären Signalketten-30Key enzyme involved in intracellular signaling chain-30

transduktion ein,e entscheidende Rolle spielt und eng mit der Regulation von kontraktilen, sekretorischen und proliferativen Prozessen verknüpft ist.transduction, plays a crucial role and is closely linked to the regulation of contractile, secretory and proliferative processes.

Darlegung des Wesens der ErfindungExplanation of the essence of the invention

Der vorliegenden Erfindung liegt die Aufgabe zugrunde, neue Verbindungen mit wertvollen pharmakologischen Eigenschaften aufzufinden und Verfahren zu deren Herstellung bereitzustellen .The present invention has for its object to find new compounds with valuable pharmacological properties and to provide methods for their preparation.

-2--2-

Erfindungsgemäß werden neue Bis-(lH-indol-3-yl)maleinimid-Derivate der allgemeinen Formel I,According to the invention, new bis (1H-indol-3-yl) maleimide derivatives of the general formula I

(D(D

1 hergestellt, in welcher R und R gleich oder verschieden sind und Wasserstoff, eine geradkettige oder verzweigte Alkylgruppe mit 1 bis 18 C-Atomen, eine unsubstituierte oder mit bis zu drei C₁_₄~Alkylgruppen, C₁_₄-Alkoxygruppen oder Halogenatomen substituierte Benzylgruppe, eine Aminoalkylgruppe mit bis zu C-Atomen, die am Stickstoffatom unsubstituiert oder mono- oder disubstituiert durch Benzyl- oder Alkylreste mit 1 bis 4 C-Atomen ist, oder bei der die Substituenten zusammen mit dem Stickstoffatom einen heterozyklischen Ring mit 3 bis 6 C-Atomen bilden, wobei die Alkylkette durch weitere C-j^-Alkylreste, eine Hydroxygruppe oder eine Cj^-Alkoxygruppe substituiert sein kann, eine Amidinothioalkylgruppe mit bis zu 12 C-Atomen, eine Nitroguanidinoalkylgruppe mit bis zu 12 C-Atomen, eine Isothiocyanoalkylgruppe mit bis zu 12 C-Atomen, einen Epoxyalkylrest mit bis zu 6 C-Atomen, einen Alkoxycarbonylalkylrest mit bis zu 6 C-Atomen, einen Rest -CH₂-CO-NR¹¹R¹², bei dem R¹¹ und R¹² gleich oder verschieden sind und für Wasserstoff, eine Alkylgruppe mit 1 bis 6 C-Atomen oder eine Benzylgruppe stehen, einen Halogenalkyl- oder Hydroxyalkylrest, der gegebenenfalls mit einem Halogenatom oder iuit einer Hydroxygruppe substituiert sein kann, oder einen gegebenenfalls mit bis zu drei Hydroxygruppen substituierten Alkoxycilkylrest mit jeweils bis zu 6 C-Atomen, eine Acylgruppe mit 1 bis 4 C-Atomen, oder einen Glycosidrest bedeuten, R³, R , R⁵, R⁶, R⁷, R⁸, R⁹ und R¹⁰ unabhängig voneinander Wasserstoff, C₁_₄-Alkyl, C_1-4-AIkOXy, C_1-4-ACyIoXy, Kalogen, eine Nitrogruppe, eine unsubstituierte oder durch Benzyl- oder1 was prepared, in which R and R are identical or different and are hydrogen, a linear or branched alkyl group having 1 to 18 carbon atoms, an unsubstituted or with up to three C ₁ _ ₄ ~ alkyl groups, C ₁ _ ₄ alkoxy groups or halogen atoms substituted benzyl group, an aminoalkyl group having up to carbon atoms which is unsubstituted or monosubstituted or disubstituted by benzyl or alkyl radicals having 1 to 4 carbon atoms on the nitrogen atom, or wherein the substituents together with the nitrogen atom, a heterocyclic ring with 3 to Form 6 C atoms, wherein the alkyl chain may be substituted by further Cj ^ -alkyl radicals, a hydroxy group or a Cj ^ alkoxy group, an amidinothioalkyl group having up to 12 C atoms, a Nitroguanidinoalkylgruppe having up to 12 C atoms, an isothiocyanoalkyl group with up to 12 C atoms, an epoxyalkyl radical having up to 6 C atoms, an alkoxycarbonylalkyl radical having up to 6 C atoms, a radical -CH ₂ -CO-NR ¹¹ R ¹² , in which R ¹¹ and R ^{12 are the} same or different and are hydrogen, an alkyl group having 1 to 6 carbon atoms or a benzyl group, a haloalkyl or hydroxyalkyl radical which may be optionally substituted with a halogen atom or iuit a hydroxy group, or optionally with up to three Hydroxy groups substituted Alkoxycilkylrest each having up to 6 C atoms, an acyl group having 1 to 4 carbon atoms, or a glycoside radical, R ³ , R, R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ and R ^{10 are} independent represent hydrogen, C ₁ _ ₄ alkyl, C _1-4 -alkoxy, C _1-4 -ACyIoXy, Kalogen, a nitro group, an unsubstituted or benzyl or

Alkylreste mit 1 bis 4 C-Atomen mono- oder disubstituierte Aminogruppe, eine Benzyloxygruppe, eine nydroxygruppe, eine Aminoalkoxygruppe mit bis zu 12 C-Atomen, die am Stickstoffatom unsubstituiert oder mono- oder disubstituiert durch Benzyl- oder Alkylreste mit 1 bis 4 C-Atomen sein kann oder bei der die Substituenten zusammen mit dem Stickstoffatom einen heterozyklischen Ring mit 3 bis 6 C-Atomen bilden, wobei die Alkylkette durch weitere C^^-Alkylreste, eine Hydroxygruppe oder eine C₁_₄-Alkoxygruppe substituiert sein kann, eine Trifluormethylgruppe oder zwei benachbarte Reste zusammen eine Methylendioxygruppe bedeuten, mit der Maßgabe, daß nicht alle Reste R¹ bis R¹⁰ gleich Wasserstoff sind oder, wenn R⁴ bzw. R⁴ und R⁹ gleich Hydroxyl sind, alle übrigen Reste nicht gleich Wasserstoff sind, und deren pharmakologisch unbedenkliche Salze sowie Arzneimittel mit einem Gehalt an mindestens einer der Verbindungen I.Alkyl radicals having 1 to 4 carbon atoms mono- or di-substituted amino group, a benzyloxy group, a hydroxy group, an aminoalkoxy group having up to 12 carbon atoms unsubstituted on the nitrogen atom or mono- or disubstituted by benzyl or alkyl radicals having 1 to 4 carbon atoms may be atoms or in which the substituents form a heterocyclic ring having 3 to 6 carbon atoms together with the nitrogen atom, wherein the alkyl chain through more C ^^ - ₄ alkoxy group may be substituted alkyl radicals, a hydroxy group or a C ₁ _, a Trifluoromethyl group or two adjacent radicals together denote a methylenedioxy group, with the proviso that not all radicals R ¹ to R ¹⁰ are hydrogen or, when R ⁴ or R ⁴ and R ⁹ are hydroxyl, all other radicals are not equal to hydrogen, and their pharmacologically acceptable salts and medicaments containing at least one of the compounds I.

Bevorzugt werden Verbindungen der Formel I hergestellt, in welcher R und R gleich oder verschieden sind und Wasserstoff, eine geradkettige oder verzweigte Alkylgruppe mit 1 bis 4 C-Atomen, eine Aminoalkylgruppe mit 1 bis 4 C-Atomen in der Alkylgruppe, die an der Alkylgruppe durch Alkoxygruppen mit 1 bis 4 C-Atomen oder durch Hydroxygruppen substituiert sein kann, und die am Stickstoffatom unsubstituiert oder mono- oder disubstituiert durch Alkylreste mit 1 bis 4 C-Atomen sein kann oder bei der die Substituenten zusammen mit dem Stickstoffatom einen heterozyklischen Ring mit 3 bis 6 C-Atomen bilden, bedeuten, R³, R⁶, R⁷ und Rⁱ⁰ Wasserstoff bedeuten und R⁴, R⁵, R⁸ und R⁹ unabhängig voneinander Wasserstoff, C_1-4-Al¹KyI, C_1-4-AIkOXy, Halogen, eine Benzyloxygruppe, eine Hydroxygruppe, eine 0 Aminoalkoxygruppe mit 1 bis 4 C-Atomen in der Alkylgruppe, die an der Alkylgruppe durch Alkoxygruppen mit 1 bis 4 C-Atomen substituiert sein kann, und die am Stickstoffatom unsubstituiert oder mono- oder disubstituiert durch Alkylreste mit 1 bis 4 C-Atomen sein kann oder bei der die Substituenten 5 zusammen mit dem Stickstoffatom einen heterozyklischen Ring mit 3 bis 6 C-Atomen bilden, bedeuten oder zwei benachbarte Reste R⁴, R⁵, R⁸ und R⁹ bedeuten zusammen eine Methylendioxygruppe.Preference is given to preparing compounds of the formula I in which R and R are identical or different and are hydrogen, a straight-chain or branched alkyl group having 1 to 4 C atoms, an aminoalkyl group having 1 to 4 C atoms in the alkyl group, and the alkyl group may be substituted by alkoxy groups having 1 to 4 carbon atoms or by hydroxy groups, and which may be unsubstituted or mono- or disubstituted on the nitrogen atom by alkyl radicals having 1 to 4 carbon atoms or in which the substituents together with the nitrogen atom having a heterocyclic ring 3 to 6 carbon atoms, R ³ , R ⁶ , R ⁷ and R ^{i0 are} hydrogen and R ⁴ , R ⁵ , R ⁸ and R ⁹ independently of one another are hydrogen, C _1-4 -Al ¹ KyI, C _{1 -4} -alkoxy, halogen, a benzyloxy group, a hydroxy group, a 0 aminoalkoxy group having 1 to 4 carbon atoms in the alkyl group, which may be substituted on the alkyl group by alkoxy groups having 1 to 4 carbon atoms, and unsubstitu on the nitrogen atom or mono- or disubstituted by alkyl radicals having 1 to 4 carbon atoms or in which the substituents 5 together with the nitrogen atom form a heterocyclic ring having 3 to 6 carbon atoms, or two adjacent radicals R ⁴ , R ⁵ , R ⁸ and R ⁹ together represent a methylenedioxy group.

-4--4-

Ganz besonders bevorzugt werden Bis-(lH-indol-3-yl)-maleinimide der allgemeinen Formel I hergestellt,Very particular preference is given to preparing bis (1H-indol-3-yl) -maleimides of the general formula I

1 21 2

in denen R und/oder R Wasserstoff,in which R and / or R are hydrogen,

' Methyl-, Ethyl-, n-Propyl-, Isopropyl-, η-Butyl-, Senzyl-, δ Acetyl-, Methoxycarbonylmethyl-, 2-Methoxyethyl-, 2-Aminoethyl, 3-Aminopropyl-, Ι-ΑΐΛΪηο-2-propyl-, 2-Dimethylaminoethyl-, 3-Dimethylamino-l-propyl-, 3-Dimethylamino-2-propyl-, 2-Diethylaminoethyl-, 2-(N-Benzyl-N-methylamino) ethyl, 3-(N-Benzyl-N-methylamino)propyl-, 3-Dimethylamino-2-hydroxy-1-propyl-, 2-Piperidinoethyl-, 3-Piperidinopropyl-, 2-Pyrrolidinoethyl-, 3-Pyrrolidinopropyl-, 2-Morpholinoethyl-, 3-Moirpholinopropyl-, Pyrrolidin-2-ylmethyl-, N-Methyl-pyrrolidin-2-ylmethyl-, Glucosyl-, Rhamnosyl-, Ribosyl-, Deoxyribosyl-, Aminoglycosyl-, 3-Hydroxypropyl-, 2-Carboxyethyl-, 2-Dimethylaminoethylcarbonyl-, Dimethylaminomethylcarbonyl-, 2-Hydroxyethoxymethyl-, (2-Hydroxy-l-hydroxymethyl)ethoxymethyl- oder (3-Hydroxy-l-hydroxymethyl)propoxymethylgruppen bedeuten und R⁵ und/oder R⁸ Wasserstoff, Chlor, Brom, Fluor oder Trifluormethyl-, Methyl-, Ethyl-, Hydroxy-, Benzyloxy-,'Methyl, ethyl, n-propyl, isopropyl, η-butyl, senzyl, δ acetyl, methoxycarbonylmethyl, 2-methoxyethyl, 2-aminoethyl, 3-aminopropyl, Ι-ΑΐΛΪηο-2 propyl, 2-dimethylaminoethyl, 3-dimethylamino-1-propyl, 3-dimethylamino-2-propyl, 2-diethylaminoethyl, 2- (N -benzyl-N-methylamino) ethyl, 3- (N-benzyl N-methylamino) propyl, 3-dimethylamino-2-hydroxy-1-propyl, 2-piperidinoethyl, 3-piperidinopropyl, 2-pyrrolidinoethyl, 3-pyrrolidinopropyl, 2-morpholinoethyl, 3-Moirpholinopropyl , Pyrrolidin-2-ylmethyl, N-methylpyrrolidin-2-ylmethyl, glucosyl, rhamnosyl, ribosyl, deoxyribosyl, aminoglycosyl, 3-hydroxypropyl, 2-carboxyethyl, 2-dimethylaminoethylcarbonyl, dimethylaminomethylcarbonyl -, 2-hydroxyethoxymethyl, (2-hydroxy-1-hydroxymethyl) ethoxymethyl or (3-hydroxy-1-hydroxymethyl) propoxymethyl and R ⁵ and / or R ^{8 is} hydrogen, chlorine, bromine, fluorine or trifluoromethyl, methyl , Ethyl, hydroxy, benzyloxy,

Methoxy-, Amino-, Dimethyl ami no-, 2-Aminoethoxy-, l-Ammo-2-propoxy-, 3-Aminopropoxy-, 2-Dimethylaminoethoxy-, 3-Dimethylamino-1-propoxy-, 3-Dimethylamino-2-propoxy-, 2-Diethylaminoethoxy-, 2-[N-Benzyl-N-methylamino]ethoxy-, 3-[N-Benzyl-N-methylamino]propoxy-, 3-Dimethylamino-2-hydroxy-1-Methoxy, amino, dimethylamino, 2-aminoethoxy, 1-amino-2-propoxy, 3-aminopropoxy, 2-dimethylaminoethoxy, 3-dimethylamino-1-propoxy, 3-dimethylamino-2-one propoxy, 2-diethylaminoethoxy, 2- [N -benzyl-N-methylamino] ethoxy, 3- [N-benzyl-N-methylamino] propoxy, 3-dimethylamino-2-hydroxy-1

propoxy-, 2-Piperidmoethoxy-, 3-Piperidinopropoxy-, 2-Pyrrolidinoethoxy-, 3-Pyrrolidinopropoxy, Pyrrolidin-2-ylmethoxy-, 2-Morpholinoethcxy-, 3-Morpholinopropoxy-, 2-Piperazinoethoxy-, 3-Piperazinopropoxy- oder N-Methyl-propoxy, 2-piperidmoethoxy, 3-piperidinopropoxy, 2-pyrrolidinoethoxy, 3-pyrrolidinopropoxy, pyrrolidin-2-ylmethoxy, 2-morpholinoethoxy, 3-morpholinopropoxy, 2-piperazinoethoxy, 3-piperazinopropoxy or N -Methyl-

pyrrolidin-2-ylmethoxygruppen oder R⁴ und R und/oder R und R 30pyrrolidin-2-ylmethoxy groups or R ⁴ and R and / or R and R 30

zusammen eine Methylendioxygruppe darstellen.together represent a methylenedioxy group.

-s--s

Die erfindungsgemäß erhaltenen Verbindungen der allgemeinen Formel I einschließlich solcher, bei denen R bis RThe compounds of general formula I obtained according to the invention including those in which R to R

4 4 9 Wasserstoff oder bei denen R bzw. R und R glaich Hydroxyl und die übrigen Reste R bis R Wasserstoff sind, werden zur Herstellung von Arzneimitteln für die -Prävention oder Behandlung von Krankheiten, bei denen die Hemmung der Proteinkinase C von Bedeutung ist, eingesetzt.4 hydrogen or in which R or R and R are hydroxyl and the other radicals R to R are hydrogen, are used for the preparation of medicaments for the prevention or treatment of diseases in which the inhibition of protein kinase C is important, used.

Die Erfindung betrifft nun Verfahren zur Herstellung von Bis-(lH-indol-3-yl)-maleinimid-Derivaten der allgemeinen Formel I, welche dadurch gekennzeichnet sind, daß man entwederThe invention now relates to processes for the preparation of bis (1H-indol-3-yl) -maleimide derivatives of the general formula I, which are characterized in that either

A) ein Dibrommaleinimid der allgemeinen Formel II,A) a Dibrommaleinimid the general formula II,

Z 15 ^.Z 15 ^.

0=<0 = <

Brbr

in welcher Z eine geeignete abspaltbare Schutzgruppe ist, mit einem Indol-Grignardreagenz der allgemeinen Formel A,in which Z is a suitable cleavable protecting group, with an indole Grignard reagent of the general formula A,

R 'R '

(A)(A)

Mg HaiMg shark

in welcher R⁷, R⁸, R⁹ und R^ltt die oben genannte Bedeutung haben, nicht jedoch Hydroxy ader Acyloxy sind, nach an sich bekannten Methoden umsetzt, und das erhaltene Produkt der allgemeinen Formel III,in which R ⁷ , R ⁸ , R ⁹ and R ^{ltt have} the abovementioned meaning, but are not hydroxy or acyloxy, is reacted by methods known per se, and the product of general formula III obtained,

(III)(III)

-β--β-

bei der R Wasserstoff bedeutet, gegebenenfalls am Indolstickstoff mit einem Alkylierungsmittel R^3--X, wobei R¹ mit Ausnahme von Wasserstoff die oben genannten Bedeutungen hat, nicht jedoch funktioneile Gruppen enthält, die die nachfolgenden Umsetzungen stören wurden, und X für eine leicht austretende Gruppe, wie z.B. Chlor oder Brom, steht, in an sich bekannter Weise alkyliert, wobei ein Produkt der allgemeinen Formel III erhalten wird, bei dem R¹ verschieden von Wasserstoff ist, und anschließend Produkt III mit einem Indolgrignardreagenz der allgemeinen Formel (B),in which R is hydrogen, optionally at the indole nitrogen with an alkylating agent R ³ -X, wherein R ¹ except the hydrogen has the abovementioned meanings, but does not contain functional groups that would disturb the subsequent reactions, and X is a readily exiting Group, such as chlorine or bromine, is alkylated in a conventional manner to give a product of general formula III is obtained in which R ^{1 is} different from hydrogen, and then product III with a Indolgrignardreagenz the general formula (B),

(B)(B)

Mr HaiMr. Hai

in welcher R³, R⁴, R⁵ und R⁶ die oben genannte Bedeutung haben, nicht jedoch Hydroxy oder Acyloxy sind, umsetzt und gegebenenfalls anschließend mit einem Alkylierungsmittel der allgemeinen Formel R²-X, in der R² mit Ausnahme von Wasserstoff die oben genannten Bedeutungen hat, nicht jedoch funktionelle Gruppen enthält, die die nachfolgenden Umsetzungen stören würden und X die oben genannte Bedeutung hat, alkyliert zu einem Produkt der allgemeinen Formel IV,in which R ³ , R ⁴ , R ⁵ and R ^{6 have} the abovementioned meaning, but are not hydroxy or acyloxy, and if appropriate subsequently reacted with an alkylating agent of the general formula R ² -X, in which R ² with the exception of hydrogen has the abovementioned meanings but does not contain functional groups which would disturb the subsequent reactions and X has the abovementioned meaning, alkylated to give a product of general formula IV,

(IV)(IV)

wonach man die substituierte Imidgruppe in die unsubstituierte Imidgruppe der Verbindung der allgemeinen Formel I überführt,after which the substituted imide group is converted into the unsubstituted imide group of the compound of general formula I,

oderor

B) ein Produkt der allgemeinen Formel VB) a product of general formula V

-7--7-

(V)(V)

bei der S und Z eine geeignete abspaltbare Schutzgruppe bedeuten, mit einem Indolgrignardreagenz der allgemeinen Formel (B)in which S and Z represent a suitable cleavable protecting group, with an indole-Grignard reagent of the general formula (B)

(B)(B)

Mg HaiMg shark

in welcher R³, R⁴, R⁵ und R⁶ die oben genannte Bedeutung haben, nicht jedoch Hydroxy oder Acyloxy sind, umsetzt und gegebenenfalls anschließend mit einem Alkylierungsmittel der allgemeinen Formel R²-X, in der R² mit Ausnahme von Wasserstoff die oben genannten Bedeutungen hat, nicht jedoch funktioneile Gruppen enthält, die die nachfolgenden Umsetzungen stören wurden und X die oben genannte Bedeutung hat, alkyliert zu einem Produkt der allgemeinen Formel VIin which R ³ , R ⁴ , R ⁵ and R ^{6 have} the abovementioned meaning, but are not hydroxy or acyloxy, and if appropriate subsequently reacted with an alkylating agent of the general formula R ² -X, in which R ² with the exception of hydrogen has the abovementioned meanings, but does not contain functional groups which would disturb the subsequent reactions and X has the abovementioned meaning, alkylated to give a product of the general formula VI

(VI)(VI)

wonach man die geschützte Indolgruppe in die freie Indolgruppe und die substituierte Imidgruppe in die unsubstituxerte Imidgruppe der Verbindung der allgemeinen Formel I überführt, wobei R¹ für Wasserstoff steht, und R² bis R¹⁰ die oben genannte Bedeutung haben,according to which the protected indole group is converted into the free indole group and the substituted imide group into the unsubstituxed imide group of the compound of the general formula I where R ^{1 is} hydrogen and R ² to R ^{10 have} the abovementioned meaning,

-¹J-- ^{1 year}

oderor

C) ein Dibrommaleinimid der allgemeinen Formel IIC) a Dibrommaleinimid the general formula II

(H)(H)

in welcher Z eine geeignete abspaltbars Schutzgruppe ist, mit einem Überschuß an Indolgrignardreagenz der allgemeinen Formel (A)in which Z is a suitable cleavable protecting group, with an excess of Indolgrignardreagenz the general formula (A)

(A)(A)

Mg HaiMg shark

7 ft Q 1Π7 ft Q 1Π

in welcher R , R , R und R^iU die oben genannte Bedeutung haben, nicht jedoch Hydroxy oder Acyloxy sind, umsetzt und das erhaltene Produkt der allgemeinen Formel VIIin which R, R, R and R ^{iU have} the abovementioned meaning, but are not hydroxy or acyloxy, and the resulting product of the general formula VII

(VII)(VII)

1010

gegebenenfalls am Indolstickstoff mit einem Alkylierungsmittel R^-X₁ wobei R¹ mit Ausnahme von Wasserstoff die oben genannten Bedeutungen hat, nicht jedoch funktionelle Gruppen enthält, die die nachfolgenden Umsetzungen stören wurden und X für eine leicht austretende Gruppe, wie z.B. Chlor oder Brom, steht, alkyliert, wobei ein Produkt der allgemeinen Formel VIIIoptionally on the indole nitrogen with an alkylating agent R 1 -X ₁ where R ¹ , except for hydrogen, has the abovementioned meanings but does not contain functional groups which would disturb the subsequent reactions and X is a readily leaving group, such as, for example, chlorine or bromine, is alkylated, wherein a product of general formula VIII

-8a--8a-

(VIII)(VIII)

erhalten wird, bei der R¹ verschieden von Wasserstoff und R² gleich Wasserstoff und R⁷ bis R¹⁰ eine der eben genannten Bedeutungen besitzen, nicht jedoch für Hydroxy oder Acyloxy stehen, wonach man die substituierte Imidgruppe in die unsubstituierte Imidgruppe der Verbindung der allgemeinen Formel I überführt.is obtained, wherein R ^{1 is} different from hydrogen and R ² is hydrogen and R ⁷ to R ^{10 have} one of the meanings just mentioned, but not hydroxy or acyloxy, after which the substituted imide group in the unsubstituted imide group of the compound of general formula I convicted.

Die Darstellung der Verbindungen der allgemeinen Formel I gemäß Anspruch 1 erfolgt in Analogie zu den in der Literatur beschriebenen Verfahren (Tetrahedron 1988, 44, 2887); Tetrahedron Lett. 1985, 4015; EP-A-O 269 0 25) oder durch geeignete Abwandlungen dieser Verfahren.The preparation of the compounds of general formula I according to claim 1 is carried out in analogy to the methods described in the literature (Tetrahedron 1988, 44, 2887); Tetrahedron Lett. 1985, 4015; EP-A-0 269 0 25) or by suitable modifications of these methods.

Produkte der allgemeinen Formel VIII, in denen R¹ verschieden von Wasserstoff ist und R² gleich Wasserstoff ist, können mit einem Alkylierungsmittel R²-X, wobei R² mit Ausnahme von Wasserstoff die oben genannten Bedeutungen hat und von R¹ verschieden ist und X für eine leicht austretende Gruppe, wie z.B. Chlor oder Brom, steht, zu einem Produkt der allgemeinen Formel VIII umgesetzt werden wobei R¹ ungleich R^?> und beide Reste verschieden von Wasserstoff sind.Products of the general formula VIII in which R ^{1 is} different from hydrogen and R ² is hydrogen can be reacted with an alkylating agent R ² -X, where R ^2, with the exception of hydrogen, has the abovementioned meanings and is different from R ¹ and X is a readily leaving group, such as chlorine or bromine, to be converted to a product of general formula VIII wherein R ^{1 are} different R ^?> and both radicals are different from hydrogen.

Nach überführung der substituierten Imidgruppe in VII bzw. VIII in die freie Imidgruppe gelangt man zu Verbindungen der allgemeinen Formel I, in der R¹ bis R¹⁰ die oben genannten Bedeutungen besitzen und R³ gleich R¹⁰, R⁴ gleich R⁹, R⁵ gleich R³ und R⁶ gleich R⁷ sind.After conversion of the substituted imide group into VII or VIII in the free imide group leads to compounds of general formula I in which R ¹ to R ^{10 have} the meanings mentioned above and R ³ is R ¹⁰ , R ⁴ is R ⁹ , R ⁵ R ³ and R ^{6 are} equal to R ⁷ .

-9--9-

Symmetrisch substituierte Bisindolylmaleinimide der allgemeinen Formel I, bei der R¹ und R² Wasserstoff sind, und R³ glsich R¹⁰, R⁴ gleich R⁹, R⁵ gleich R⁸, R⁶ gleich R⁷ sir.d und die oben angegebene Bedeutungen haben, nicht jedoch Hydroxyl oder Acyloxy sind, können auch durch Umsetzung von Dibrommaleinimid mit einem Überschuß an Indolgrignardreagenz der allgemeinen Formel A erhalten werden.Symmetrically substituted bisindolylmaleimides of the general formula I in which R ¹ and R ^{2 are} hydrogen, and R ³ is R ¹⁰ , R ⁴ is R ⁹ , R ⁵ is R ⁸ , R ⁶ is R ⁷ sir.d and the meanings given above have, but are not hydroxyl or acyloxy, can also be obtained by reacting Dibrommaleinimid with an excess of Indolgrignardreagenz the general formula A.

-ίο--ίο-

Die in den Verfahren A bis C beschriebene Überführung der substituierten Imide in die freien Imide kann in Analogie zu den in der Literatur beschriebenen Verfahren erfolgen. Bedeutet Z z.B. Methyl, so wird durch Umsetzung mit einer Lösung von Kaliumhydroxid in Wasser/Methanol und anschließendem Ansäuern zunächst das entsprechende cyclische Anhydrid hergestellt und dieses durch Erhitzen mit Ammoniumacetat oder ethanolischer Ammoniaklösung in das freie Imid übergeführt. (Tetrahedron 44, 1988, 2887). Bedeutet Z z.B. Benzyloxymethyl, so wird die Überführung ins freie Imid durch Hydrierung über Palladium/Kohle durchgeführt. (Tetrahedron Lett. 26, 1985, 4015).The conversion of the substituted imides into the free imides described in processes A to C can be carried out analogously to the processes described in the literature. If Z is e.g. Methyl, the corresponding cyclic anhydride is first prepared by reaction with a solution of potassium hydroxide in water / methanol and subsequent acidification and this converted by heating with ammonium acetate or ethanolic ammonia solution in the free imide. (Tetrahedron 44, 1988, 2887). If Z is e.g. Benzyloxymethyl, the conversion into the free imide is carried out by hydrogenation over palladium / carbon. (Tetrahedron Lett. 26, 1985, 4015).

Als Schutzgruppe S in Verfahren B eignen sich besonders die tert.-Butoxycarbonylgruppe (BOC-Gruppe), der p-Toluolsulfonsäurerest (Tosyl-Rest) und die Trimethylsilylethoxymethylgruppe (SEM-Gruppe). Die BOC-Gruppe und der Tosylrest werden bei der Überführung des substituierten Imids ins freie Imid abgespalten, die SEM-Gruppe kann mit Tetra-n-butylammonivunfluorid leicht abgespalten werden (J. Org.Suitable protecting group S in process B are especially the tert-butoxycarbonyl group (BOC group), the p-toluenesulfonic acid residue (tosyl residue) and the trimethylsilylethoxymethyl group (SEM group). The BOC group and the tosyl radical are split off during the conversion of the substituted imide into the free imide, the SEM group can be easily cleaved off with tetra-n-butylammoniumfluoride (J. Org.

Chem. 49, 1984, 205).Chem. 49, 1984, 205).

Zur Durchführung der Alkylierungen nach Verfahren A bis C mit Verbindungen R^-X bzw. R-X besonders geeignete Basen sind Hydride, Carbonate, Amide, Hydroxide, Oxide oder Alkoxide der Alkali- oder Erdalkalimetalle oder lithiumorganische Verbindungen. Als Lösungsmittel eignen sich insbesondere dipolare aprotische Lösungsmittel wie Aceton, Dimethylsulfoxid, Dimethylformamid oder Tetrahydrofuran. Die Glycosidierung erfolgt unter Verwendung geeigneter O-acylierter Glycosylhalogenide.For carrying out the alkylations according to methods A to C with compounds R ^ -X or R-X particularly suitable bases are hydrides, carbonates, amides, hydroxides, oxides or alkoxides of alkali or alkaline earth metals or organolithium compounds. Suitable solvents are in particular dipolar aprotic solvents such as acetone, dimethyl sulfoxide, dimethylformamide or tetrahydrofuran. The glycosidation is carried out using suitable O-acylated glycosyl halides.

Verbindungen der allgemeinen Formel I, bei denen R^x und/oder R einen Alkoxycarbonylalkylrest bedeuten, können nach Verfahren A bis C, ausgehend von N-Benzyloxymethyldibrommaleinimid und unter Vorwendung geeigneter Alkoxycarbonylalkylhalogenide hergestellt werden. Die Alkylierung erfolgt in diesem Falle 5 nach Durchführung der Reaktionen mit dem Indolgrignardreagenz. Durch Reaktion an der Alkoxycarbonylgruppe mit geeignetenCompounds of the general formula I in which R ^x and / or R represent an alkoxycarbonylalkyl radical can be prepared by processes A to C, starting from N-benzyloxymethyldibromaleimide and using appropriate alkoxycarbonylalkyl halides. The alkylation takes place in this case 5 after carrying out the reactions with the Indolgrignardreagenz. By reaction at the alkoxycarbonyl group with suitable

Aminen können hieraus nach an sich bekannten Methoden die entsprechenden Amide hergestellt werden.Amines can be prepared therefrom according to methods known per se, the corresponding amides.

Verbindungen der allgemeinen Formel I, bei denen R¹ und/oder R² einen Halogenaij-.ylrest bedeuten, werden aus den entsprechenden Hydroxyalkylverbindungen nach an sich bekannten Methoden zur Überführung eines Alkohols in ein Halogenid hergestellt.Compounds of the general formula I in which R ¹ and / or R ² signify a haloalkyl radical are prepared from the corresponding hydroxyalkyl compounds by methods known per se for converting an alcohol into a halide.

Verbindungen der allgemeinen Formel I, bei denen R¹ und/oder R² einen Amidinothioalkylrest bedeuten, werden aus den entsprechenden Halogenalkylverbindungen durch Umsetzung mit Thioharnstoff erhalten.Compounds of the general formula I in which R ¹ and / or R ² denote an amidinothioalkyl radical are obtained from the corresponding haloalkyl compounds by reaction with thiourea.

Verbindungen der allgemeinen Formel I, bei denen R¹ und/oder R² eine Nitroguanidinoalkylgruppe bedeuten, v/erden aus den entsprechenden Aminoalkylverbindungen durch Umsetzung mit 1-Nitroguanyl-3,4-dimethylpyrazol erhalten.Compounds of the general formula I in which R ¹ and / or R ² denote a nitroguanidinoalkyl group are obtained from the corresponding aminoalkyl compounds by reaction with 1-nitroguanyl-3,4-dimethylpyrazole.

Verbindungen der allgemeinen Formel I, bei denen R¹ und/oder R² eine Isothiocyanatoalkylgruppe bedeuten, werden aus den entsprechenden Aminoalkylverbindungen durch Umsetzung mit Thiocarbonyldiimidazol erhalten.Compounds of the general formula I in which R ¹ and / or R ² signify an isothiocyanatoalkyl group are obtained from the corresponding aminoalkyl compounds by reaction with thiocarbonyldiimidazole.

Verbindungen der allgemeinen Formel I, bei denen R¹ und/oder R² gleich Acyl bedeutet, werden aus den Verbindungen derCompounds of the general formula I in which R ¹ and / or R ² is acyl are selected from the compounds of the

allgemeinen Formel I mit R¹ und/oder R² gleich Wasserstoff durch Acylierung unter Verwendung eines geeigneten Acylhalogenids oder Anhydrids in einem geeigneten Lösungsmittel wie z.B. Pyridin hergestellt.general formula I with R ¹ and / or R ² equal to hydrogen by acylation using a suitable acyl halide or anhydride in a suitable solvent such as pyridine.

Verbindungen der allgemeine Formel I, bei denen R und/oder R einen Epoxyalkylrest bedeutet, werden aus Verbindungen der allgemeinen Formel I, bei der R¹ und/oder R² gleich Wasserstoff sind und R³ bis R¹⁰ die angegebene Bedeutung besitzen, nicht jedoch für Hydroxyl stehen, durch Umsetzung mit einem geeigneten Halogenepoxyalkan hergestellt. Erfolgt die Umsetzung von Halogenepoxyalkanen mit Verbindungen der aligemeinen Formel VI oder VII und steht Z für Methyl, so wird der Epoxidring bei dt c Überfühirung des substituierten Imids ins freie Imid unter Bildung von vicinalen Diolen geöffnet und man erhältCompounds of the general formula I in which R and / or R is an epoxyalkyl radical are not compounds of the general formula I in which R ¹ and / or R ² are hydrogen and R ³ to R ^{10 have} the meaning indicated for hydroxyl, prepared by reaction with a suitable halo-epoxyalkane. If the reaction of haloalkoxyalkanes with compounds of the general formula VI or VII and Z is methyl, the epoxide ring is opened in dt c Überfühirung of the substituted imide in the free imide to form vicinal diols and obtained

2999ΨΟ2999ΨΟ

Verbindungen der allgemeinen Formel I, bei denen R¹ und/oder R² für einen Dihydroxyalkylrest steht. Der Epoxidring kann auch vor der Abspaltung der Schutzgruppe Z mit Aminen geöffnet werden. Nach überführung der substituierten Imidgruppe in die freie Imidgruppe erhält man Verbindungen der allgemeinen Formel I, in welcher R¹ und/oder R² für einen Aminohydroxyalkylrest stehen.Compounds of the general formula I in which R ¹ and / or R ^{2 is} a dihydroxyalkyl radical. The epoxide ring can also be opened with amines before the removal of the protective group Z. After conversion of the substituted imide group into the free imide group, compounds of the general formula I in which R ¹ and / or R ^{2 represent} an aminohydroxyalkyl radical are obtained.

Verbindungen der allgemeinen Formel I, in welcher einer oder bis zu vier der Reste R³ bis R¹⁰ für eine Hydroxygruppe stehen, ^Λ können in an sich bekannter Weise durch Etherspaltung von Verbindungen der allgemeinen Formel I, in welcher einer oder mehrere der Reste R³ bis R¹⁰ für eine Cl-C4-Alkoxygruppe stehen, hergestellt werden.Compounds of general formula I in which one or up to four of the radicals R ³ to R ¹⁰ is a hydroxy group, ^Λ can in manner known per se by ether cleavage of compounds of general formula I in which one or more of the radicals R ³ until R ^{10 is} a C 1 -C 4 alkoxy group.

Verbindungen der allgemeinen Formel I, in welcher einer oder bis zu vier der Reste R³ bis R¹⁰ für eine unsubstituierte oder substituierte Aminoalkoxygruppe bzw. Acyloxygruppe stehen, können in an sich bekannter Weise durch Aminoalkylierung bzw. Acylierung von Verbindungen der allgemeinen Formel I, in welcher einer oder bis zu vier der Reste R³ bis R¹⁰ für eine Hydroxygruppe stehen, hergestellt werden.Compounds of the general formula I in which one or up to four of the radicals R ³ to R ^{10 represent} an unsubstituted or substituted aminoalkoxy group or acyloxy group can be prepared in a manner known per se by aminoalkylation or acylation of compounds of the general formula I, in which are one or up to four of the radicals R ³ to R ^{10 is} a hydroxy group, are prepared.

Die Verbindungen gemäß Anspruch 1 können auch nach den in der EP-A-O 328 026 genannten Verfahren hergestellt werden.The compounds according to claim 1 can also be prepared by the processes mentioned in EP-A-0 328 026.

Verbindungen der allgemeinen Formel I, die ein chirales Zentrum aufweisen, können als Stereoisomerengemische oder in Form der Enantiomeren verwendet v/erden. Die Enantiomeren können nach den für optische Trennungen von Stereoisomeren verwendeten üblichen Verfahren erhalten werden.Compounds of the general formula I which have a chiral center can be used as stereoisomer mixtures or in the form of the enantiomers. The enantiomers can be obtained by the conventional methods used for optical separations of stereoisomers.

Verbindungen der allgemeinen Formel I können gegebenenfalls als Regioisomerengemische anfallen, die nach allgemein bekannten 0 Verfahren in die Einzelverbindungen aufgetrennt werden können.If appropriate, compounds of general formula I can be obtained as regioisomer mixtures which can be separated into the individual compounds by generally known methods.

Gegenstand der vorliegenden Erfindung sind daher auch die Enantiomeren der Stereoisomerengemische sowie die Einzelverbindungen der Regioisomerengemi.sche.The present invention therefore also relates to the enantiomers of the stereoisomer mixtures and to the individual compounds of the regioisomer mixtures.

-U--U-

Basische Verbindungen der allgemeinen Formel 1, welche ein basisches Zentrum an mindestens einem der Reste R¹ bis R¹⁰ aufweisen, werden zum Zwecke der Reinigung und aus galenischen Gründen bevorzugt in kristalline, pharmakologisch verträgliche Salze übergeführt. Die Salze werden in üblicher Weise durch Neutralisation der Basen mit entsprechenden anorganischen oder organischen Säuren erhalten. Als Säuren kommen z.B. Salzsäure, Schwefelsäure, Phosphorsäure, Bromwasserstoffsäure, Essigsäure, Weinsäure, Milchsäure, Zitronensäure, Äpfelsäure, Salicylsäure, Ascorbinsäure, Malonsäure, Fumarsäure, Oxalsäure oder Bernsteinsäure in Frage. Die Säureadditionssalze werden in der Regel in an sich bekannter Weise durch Mischen der freien Base oder deren Lösungen mit der entsprechenden Säure oder· deren Lösungen in einem organischen Lösungsmittel, beispielsweise einem niederen Alkohol wie Methanol, Ethanol oder 2-Propanol oder einem niederen Keton wie Aceton oder 2-Butanon oder einem Ether wie Diethylether, Diisopropylether, Tetrahydrofuran oder Dioxan, erhalten.Basic compounds of the general formula 1 which have a basic center on at least one of the radicals R ¹ to R ¹⁰ are preferably converted into crystalline, pharmacologically acceptable salts for the purpose of purification and for galenic reasons. The salts are obtained in the usual way by neutralization of the bases with corresponding inorganic or organic acids. Examples of suitable acids are hydrochloric acid, sulfuric acid, phosphoric acid, hydrobromic acid, acetic acid, tartaric acid, lactic acid, citric acid, malic acid, salicylic acid, ascorbic acid, malonic acid, fumaric acid, oxalic acid or succinic acid. The acid addition salts are generally prepared in a manner known per se by mixing the free base or its solutions with the corresponding acid or its solutions in an organic solvent, for example a lower alcohol such as methanol, ethanol or 2-propanol or a lower ketone such as acetone or 2-butanone or an ether such as diethyl ether, diisopropyl ether, tetrahydrofuran or dioxane.

Die erfindungsgemäßen Verbindungen sind potente Inhibitoren der Proteinkinase C. überraschernderweise wirken sie {selektiv, denn man benötigt sehr viel höhere Konzentrationenen an erfindungsgemäßen Verbindungen, um andere Kinasen wie z.B. die A-Kinase, die G-Kinase oder die MLC-Kinase zu hemmen. Dies trifft insbesondere für Verbindungen der allgemeinen Formel I zu, bei denen der eine Indolrest am Indolstickstoff unsubstituiert ist, während der andere Indolres . am Indolstickstoff und im Benzoteil geeignet substituiert ist. So zeigt z.B. die Verbindung von Beispiel 1 im Enzym-Assay der Proteinkinase C eine 50%ige Inhibierung bei einer Konzentration 0 von 0,14 μιηοΙ/Liter, während die IC50-Werte gegenüber der A-Kinase, der G-Kinase und der MLC-Kinase 77 μιηοΙ/Liter, 15 μιηοΐ/liter bzw. 4,5 μΐηοΐ/liter betragen.The compounds of the invention are potent inhibitors of protein kinase C. Surprisingly, they act {selectively, because much higher concentrations of compounds of the invention are required to produce other kinases, e.g. to inhibit A kinase, G kinase or MLC kinase. This is especially true for compounds of general formula I in which one indole residue is unsubstituted at the indole nitrogen, while the other indole. is suitably substituted on the indole nitrogen and in the benzo portion. Thus, e.g. the compound of Example 1 in the enzyme assay of protein kinase C 50% inhibition at a concentration 0 of 0.14 μιηοΙ / liter, while the IC50 values compared to the A-kinase, G-kinase and MLC kinase 77th μιηοΙ / liter, 15 μιηοΐ / liter or 4.5 μΐηοΐ / liter amount.

Die Proteinkinase C spielt für die intracelluläre T.j.gnaltransduktion eine wichtige Schlüsselrolle und ist eng mit der Regulation von kontraktilen, sekretorischen und proliferativen Prozessen verknüpft. Aufgrund dieser Eigenschaften können die erfindungsgemäßen Verbindungen zur Bahandlung von Herz- und Gefäßkrankheiten wie Thrombosen,Protein kinase C plays an important key role in the intracellular T.j.gnal transduction and is closely linked to the regulation of contractile, secretory and proliferative processes. Because of these properties, the compounds according to the invention can be used for the treatment of cardiovascular diseases such as thromboses,

Arteriosklerose, Hypertension, von Entzündungsprozessen, Allergien, Krebs und bestimmten degenerativen Schaden des Zentralnervensystems sowie von Krankheiten des Immunsystems sowie viralen Erkrankungen verwendet werden. Die Verbindungen können in der jeweils geeigneten Formulierung enteral oder parenteral in Dosen von 1 bis 500 mg/kg, bevorzugt 1 bis 50 mg/kg verabreicht werden. Aufgrund der aufgefundenen guten bis . hervorragenden Selektivität gegenüber PKC im Vergleich zu anderen Proteinkinasen besitzen die erfindungsgemäßen Verbindungen sehr viel weniger Nebenwirkungen beim Einsatz gegen die genannten Krankheiten.Atherosclerosis, hypertension, of inflammatory processes, allergies, cancer and certain degenerative damage of the central nervous system as well as diseases of the immune system as well as viral diseases. The compounds may be administered enterally or parenterally in dosages of 1 to 500 mg / kg, preferably 1 to 50 mg / kg, in the appropriate formulation. Due to the found good up. excellent selectivity to PKC compared to other protein kinases, the compounds of the invention have much fewer side effects when used against the diseases mentioned.

Die erfindungsgemäßen Verbindungen der allgemeinen Formel I können in flüssiger oder fester Form oral oder parenteral appliziert werfen. Als Injektionslösung kommt vor allem Wasser zur Anwendung, welches die bei Injektionslösungen üblichen Zusätze wie Stabilisierungsmittel, Lösungsvermittler oder Puffer enthält. Derartige Zusätze sind z.B. Tartrat- und Citrat-Puffer, Ethanol, Komplexbildner (wit Äthylendiamintetraessigsäure und deren nicht-toxische Salze) sowie hochmolekulare Polymere (wie flüssiges Polyäthylenoxid) zur Viskositätsregulierung. Feste Trägerstoffe sind z.B. Stärke, Lactose, Mannit, Methylcellulose, Talkum, hochdisperse Kieselsäuren, höher molekulare Fettsäuren (wie Stearinsäure), Gelatine, Agar-Agar, Calciumphosphat, Magnesiumstearat,The compounds of the general formula I according to the invention can be administered orally or parenterally in liquid or solid form. As injection solution, especially water is used, which contains the usual additives for injection solutions such as stabilizers, solubilizers or buffers. Such additives are e.g. Tartrate and citrate buffer, ethanol, complexing agent (with ethylenediaminetetraacetic acid and its non-toxic salts) and high molecular weight polymers (such as liquid polyethylene oxide) for viscosity regulation. Solid carriers are e.g. Starch, lactose, mannitol, methylcellulose, talc, fumed silica, higher molecular weight fatty acids (such as stearic acid), gelatin, agar-agar, calcium phosphate, magnesium stearate,

.5 tierische und pflanzliche Fette, feste hochmolekulare Polymere (vie Polyäthylenglykol); für orale Applikation geeignete Zubereitungen können gewünschtenfalls zusätzliche Geschmacks- und/oder Süßstoffe enthalten..5 animal and vegetable fats, solid high molecular weight polymers (such as polyethylene glycol); If desired, preparations suitable for oral administration may contain additional flavorings and / or sweeteners.

Die folgenden Beispiele dienen der näheren Erläuterung dar 0 Erfindung.The following examples serve to illustrate in more detail 0 invention.

Beispiel 1example 1

2-(lH-Indol-3-yl)-3-(l-methyl-lH-indol-3-yl)-maleinimid2- (lH-indol-3-yl) -3- (l-methyl-lH-indol-3-yl) maleimide

0,3 g (0,87 mmol) 2-(lH-Indol-3-yl)-3-(l-methyl-lH-indol-3-yl)maleinsäureanhydrid und 15 g Ammoniumacetat werden 30 min.0.3 g (0.87 mmol) of 2- (1H-indol-3-yl) -3- (1-methyl-1H-indol-3-yl) maleic anhydride and 15 g of ammonium acetate are added for 30 min.

-15--15-

auf 140*C erhitzt. Nach dem Abkühlen wird die Reaktionsmischung mit viel Wasser verrührt, der rote Niederschlag wird abgesaugt, mit Wasser gut ausgewaschen und im Vakuum bei 0,1 Torr und 120'C getrocknet. Man erhält 0,25 g (83%) rotes Produkt vom Schmelzpunkt 210*C (zers.). RF 0,40 (Toluol:Ethanol = 10:2).heated to 140 * C. After cooling, the reaction mixture is stirred with plenty of water, the red precipitate is filtered off with suction, washed well with water and dried in vacuo at 0.1 Torr and 120'C. This gives 0.25 g (83%) of red product of melting point 210 * C (decomp.). RF 0.40 (toluene: ethanol = 10: 2).

Das als Ausgangsmaterial verwendete 2-(lH-Indol-3-yl)-3-(l-' methyl-lH-indol-3-yl)maleinsäureanhydrid wird wie folgt hergestellt: 0,5 g (1,4 mmol) 2-(lH-Indol-3-yl)-3-(l-methyllH-indol-3-yl)-N-methylmaleinimid und eine Lösung von 10 gThe starting 2- (1H-indol-3-yl) -3- (1-methyl-1H-indol-3-yl) maleic anhydride is prepared as follows: 0.5 g (1.4 mmol) 2- (1H-Indol-3-yl) -3- (1-methyl-1H-indol-3-yl) -N-methylmaleimide and a 10 g solution

'Ί Kaliumhydroxid in 100 ml Methanol/Wasser (1+1) werden 1 Stunde unter Rückfluß erhitzt. Nach dem Abkühlen wird die rote Reaktionsmischung mit halbkonz. Salzsäure angesäuert und mit Chloroform extrahiert. Nach dem Trocknen über Natriumsulfat wird das Extraktionsmittel am Rotavapor entfernt und der Rückstand mit wenig Toluol verrieben. Das rote Produkt wird abgesaugt und im Vakuum bei 0,1 Torr und 70*C getrocknet. Man erhält 0,38 g (79%) rote Kristalle vom Schmelzpunkt 234⁰C (zers.). RF = 0,60 (Toluol:Ethanol = 10:1).Potassium hydroxide in 100 ml of methanol / water (1 + 1) is refluxed for 1 hour. After cooling, the red reaction mixture with semiconc. Hydrochloric acid and extracted with chloroform. After drying over sodium sulfate, the extractant is removed on a rotary evaporator and the residue triturated with a little toluene. The red product is filtered off with suction and dried in vacuo at 0.1 Torr and 70 ° C. This gives 0.38 g (79%) red crystals of melting point 234 ⁰ C (dec.). RF = 0.60 (toluene: ethanol = 10: 1).

Das als Ausgangsmateri?l verwendete 2-(lH-Indol-3-yl)-3-(lmethyl-lH-indol-3-yl) -N-methylinaleinimid wird wie folgt hergestellt:The 2- (1H-indol-3-yl) -3- (1-methyl-1H-indol-3-yl) -N-methyl-1-enyimide used as the starting material is prepared as follows:

Eine Lösung von 9,1 mmol Ethylmagnesiumbromid in 10 ml Tetrahydrofuran wird mit einer Lösung von 1,1 g (9,1 mmol) Indol in 10 ml Tetrahydrofuran versetzt. Man rührt 1 Stunde bei 5 Raumtemperatur, versetzt mit einer Lösung von 1,2 g (3,7 mmol) 2-Brom-3-(l-methyl-lH-indol-3-yl)-N-methylraaleinimid in 10 ml Tetrahydrofuran und erhitzt 4 Stunden unter Rückfluß. Man läßt abkühlen, zersetzt die Reaktionsmischung mit einer gesättigten Lösung von Ammoniumchlorid in Wasser und extrahiert mit Essigester. Nach dem Trocknen über Natriumsulfat wird der Essigester am Rotavapor entfernt und der Rückstand an Kieselgel (Merck Art. 7734) flash chromatographiert, als Elutionsmittel wird eine Mischung aus Toluol und Ethanol (10+0,5) verwendet. Zuerst werden nicht umgesetzte Ausgangsprodukte eluiert, dann das gewünschte Produkt. Die produkthaltigen Fraktionen werden vereinigt, das Elutionsmittel wird abgezogen und der Rückstand mit wenig Toluol/Petrolether verrieben. Man erhält nach demTo a solution of 9.1 mmol of ethylmagnesium bromide in 10 ml of tetrahydrofuran is added a solution of 1.1 g (9.1 mmol) of indole in 10 ml of tetrahydrofuran. The mixture is stirred for 1 hour at room temperature, treated with a solution of 1.2 g (3.7 mmol) of 2-bromo-3- (1-methyl-1H-indol-3-yl) -N-methylraaleinimid in 10 ml of tetrahydrofuran and heated at reflux for 4 hours. It is allowed to cool, the reaction mixture is decomposed with a saturated solution of ammonium chloride in water and extracted with ethyl acetate. After drying over sodium sulfate, the ethyl acetate is removed on a rotary evaporator and the residue is flash chromatographed on silica gel (Merck Art. 7734) using as eluent a mixture of toluene and ethanol (10 + 0.5). First, unreacted starting products are eluted, then the desired product. The product-containing fractions are combined, the eluent is stripped off and the residue is triturated with a little toluene / petroleum ether. You get after the

Absaugen und Trocknen im Vakuum (0,1 Torr / 70'C) 0,6 g rote Kristalle (45%) vom Schmelzpunkt 205'C. RF = 0,32 (Toluol+Ethanol = 10+2).Vacuum-suction and drying (0.1 torr / 70 ° C.) 0.6 g of red crystals (45%) of melting point 205 ° C. RF = 0.32 (toluene + ethanol = 10 + 2).

Das als Ausgangsmaterial verwendete 2-Brom-3-(l-methyl IH-. indol-3-yl)-N-methylmaleinimid wird wie folgt hergestellt:The starting 2-bromo-3- (1-methyl-1H-indol-3-yl) -N-methylmaleimide is prepared as follows:

' 1,4 g (5 mmol) 2-Brom-3-(lH-indol-3-yl)maleinimid werden in 20 ml Dimethylformamid gelöst und unter Stickstoff vorsichtig mit 0,3 g Natriumhydrid (80%ige Suspension in Paraffinöl) versetzt. Man rührt 1 Stunde bei Raumtemperatur weiter, versetzt mit einer Lösung von 1,6 g (ll,2mmol) Methyljodid in 5 ml Dimethylformamid und erwärmt 6 Stunden auf 60*C. Nach dem Abkühlen wird das Lösungsmittel im Wasserstrahlvakuum abdestilliert und der Rückstand mit Wasser verrieben. Der orangefarbene Niederschlag wird abgesaugt und aus wenig Methanol kristallisiert.'1.4 g (5 mmol) of 2-bromo-3- (1H-indol-3-yl) maleimide are dissolved in 20 ml of dimethylformamide and treated under nitrogen carefully with 0.3 g of sodium hydride (80% suspension in paraffin oil) , The mixture is stirred for 1 hour at room temperature, treated with a solution of 1.6 g (ll, 2mmol) of methyl iodide in 5 ml of dimethylformamide and heated to 60 * C for 6 hours. After cooling, the solvent is distilled off in a water jet vacuum and the residue triturated with water. The orange precipitate is filtered off with suction and crystallized from a little methanol.

Man erhält 1,3 g (81%) orangefarbene Kristalle vom Schmelzpunkt 167⁰C. RF = 0,48 (Hexan:Ethylacetat = 1:1).1.3 g (81%) of orange crystals of melting point 167 ^° C. are obtained. RF = 0.48 (hexane: ethyl acetate = 1: 1).

Das als Ausgangsmaterial verwendete 2-Brom-3-(lH-indol-J-yl)-maleinimid wird wie folgt erhalten:The starting 2-bromo-3- (1H-indol-1-yl) -maleimide is obtained as follows:

Eine Lösung von 49,3 mmol Ethylmagnesiumbromid in 30 ml Tetrahydrofuran wird mit einer Lösung von 5,8 g (49,5 mmol) Indol in 50 ml Toluol versetzt. Man rührt 1 Stunde bei Raumtemperatur, tropft dann langsam eine Lösung von 2,5 g (9,0 mmol) Dibrommaleinimid in 20 ml Tetrahydrofuran / 50 ml Toluol hinzu und erhitzt 30 Stunden unter Rückfluß. Nach dem Abkühlen wird die Reaktionsmischung mit einer gesättigten Lösung von Ammoniumchlorid in Wasser zersetzt, die Produkte werden mit Essigester extrahiert und die organische Phase wird schließlich über Natriumsulfat getrocknet. Nach dem Einengen wird der rote Rückstand mit wenig Dichlormethan verrieben, abgesaugt und im Vakuum bei 0,1 Torr und 70*C getrocknet. Man erhält 2,2 g (75%) orangefarbenes Produkt vom Schmelzpunkt 196*C. RF = 0,35 (Hexan:Ethylacetat = 1:1).A solution of 49.3 mmol of ethylmagnesium bromide in 30 ml of tetrahydrofuran is treated with a solution of 5.8 g (49.5 mmol) of indole in 50 ml of toluene. The mixture is stirred for 1 hour at room temperature, then slowly added dropwise a solution of 2.5 g (9.0 mmol) Dibrommaleinimid in 20 ml of tetrahydrofuran / 50 ml of toluene and heated for 30 hours under reflux. After cooling, the reaction mixture is decomposed with a saturated solution of ammonium chloride in water, the products are extracted with ethyl acetate and the organic phase is finally dried over sodium sulfate. After concentration, the red residue is triturated with a little dichloromethane, filtered off and dried in vacuo at 0.1 Torr and 70 * C. 2.2 g (75%) of orange product of melting point 196 ° C. are obtained. RF = 0.35 (hexane: ethyl acetate = 1: 1).

Beispiel 2 Example 2

299990299990

-17- :-17-:

2-(lH-Indol-3-yl)-3-[l-(3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimicl2- (lH-indol-3-yl) -3- [l- (3-dimethylaminopropyl) -lH-indol-3-yl] -maleinimicl

0,20 g (0,44 mmol) 2-(lH-Indol-3-yl)-3-[l-(3-dimethylaminopropyl)-lH-indol-3-yl]maleinsäureanhydrid Hydrochlorid und 10 g Ammoniumacetat werden 30 min. auf 14O⁰C erhitzt. Nach dem Abkühlen wird mit Wasser versetzt und mit .Essigester extrahiert. Die organische Phase wird mit Natriumbicarbonatlösung und danach mit Wasser gut ausgewaschen und über Natriumsulfat getrocknet. Der Essigester wird abrotiert, der rote Rückstand mit wenig Wasser verrührt und das ausgefallene rote Produkt abgesaugt. Nach dem Trocknen im Vakuum bei 0,1 Torr / 140*C erhält man 0,165 g (91%) rotes Produkt vom Schmelzpunkt ca. 280*C (zers.). RF = 0,16 (Chloroform:Methanol = 10:2).0.20 g (0.44 mmol) of 2- (1H-indol-3-yl) -3- [1- (3-dimethylaminopropyl) -1H-indol-3-yl] maleic anhydride hydrochloride and 10 g of ammonium acetate are added for 30 min , heated to 14O ⁰ C. After cooling, water is added and extracted with .Essigester. The organic phase is washed well with sodium bicarbonate solution and then with water and dried over sodium sulfate. The ethyl acetate is removed by rotary evaporation, the red residue is stirred with a little water and the precipitated red product is filtered off with suction. After drying in vacuo at 0.1 Torr / 140 * C to obtain 0.165 g (91%) of red product of melting point about 280 * C (decomp.). RF = 0.16 (chloroform: methanol = 10: 2).

Das als Ausgangsmaterial verwendete 2-(lH-Indol-3-yl)-3-[l-(3-dimethylaminopropyl)-lH-indol-3-yl]maleinsäuroanhydrid Hydrochlorid wird wie folgt hergestellt:The starting 2- (1H-indol-3-yl) -3- [1- (3-dimethylaminopropyl) -1H-indol-3-yl] maleic anhydride hydrochloride is prepared as follows:

0,5 g (0,95 mnol) 2-(1-tert.-Butoxycarbonyl-lH-indol-3-yl)-3-[1-(3-dimethylaminopropyl)-lH-indol-3-yl]-N-methylmaleinimid und 50 ml 10%ige Kaliumhydroxidlösung (Methanol/Wasrer 1+1) werden 30 min. unter Rückfluß erhitzt. Nach dem Abkühlen v/ird vorsichtig mit konz. Salzsäure angesäuert und mit Chloroform extrahiert.0.5 g (0.95 mmol) of 2- (1-tert-butoxycarbonyl-1H-indol-3-yl) -3- [1- (3-dimethylaminopropyl) -1H-indol-3-yl] -N Methylmaleimide and 50 ml of 10% potassium hydroxide solution (methanol / Wasrer 1 + 1) are 30 min. heated to reflux. After cooling, carefully stir with conc. Hydrochloric acid and extracted with chloroform.

Die organische Phase wird mit Wasser ausgewaschen und zur Trockene eingeengt. Der rote Rückstand wird mit wenig Methanol/Toluol verrieben, abgesaugt und bei 80'C getrocknet. Man erhält 0,34 g (79,5%) dunkelrotes Produkt vom Schmelzpunkt 232-234'C (zers.).The organic phase is washed with water and concentrated to dryness. The red residue is triturated with a little methanol / toluene, filtered off with suction and dried at 80 ° C. This gives 0.34 g (79.5%) of dark red product of melting point 232-234'C (decomp.).

Das als Ausgangsmaterial verwendete 2-(1-tert.-ButoxycarbonyllH-indol-3-yl)-3-[l-(3-dimethylaminopropyl)-lH-indol-3-yl]-N- methylmaleinimid wird wie folgt hergestellt:The starting 2- (1-tert-butoxycarbonylH-indol-3-yl) -3- [1- (3-dimethylaminopropyl) -1H-indol-3-yl] -N-methylmaleimide is prepared as follows:

Eine Mischung aus 0,9 g (2,03 mmol) 2-(1-tert.-Butoxycarbony1-lH-indol-3-yl)-3-(lH-indol-3-yl)-N-methylmaleinimid (Tetrahedron 44, 2887, 1988), 0,3 g Kaliumcarbonat und 0,3 gA mixture of 0.9 g (2.03 mmol) of 2- (1-tert-butoxycarbonyl-1H-indol-3-yl) -3- (1H-indol-3-yl) -N-methylmaleimide (Tetrahedron 44 , 2887, 1988), 0.3 g of potassium carbonate and 0.3 g

(2,4 mmol) 3-Dimethylaminopropylchlorid in 10 ml Aceton wird 12 Stunden bei Raumtemperatur und 8 Stunden unter Rückfluß gerührt. Nach dem Abkühlen wird die Reaktionsmischung in Wasser gegossen und mit Essigester extrahiert. Der rote Extrakt wird eingeengt und der Rückstand an Kieselgel (Merck Art. 7734) flash chromatographiert. Als Elutionsmittel wird eine Mischung aus Toluol/Ethanol 10+1,5 verwendet. Das gewünschte Produkt wird als rotes Öl erhalten und so in obige Reaktion eingesetzt. Ausbeute 0,8 g (74%). RF = 0,20 (Toluol:Ethanol = 1:2).(2.4 mmol) of 3-dimethylaminopropyl chloride in 10 ml of acetone is stirred for 12 hours at room temperature and 8 hours under reflux. After cooling, the reaction mixture is poured into water and extracted with ethyl acetate. The red extract is concentrated and the residue flash chromatographed on silica gel (Merck Art. 7734). The eluent used is a mixture of toluene / ethanol 10 + 1.5. The desired product is obtained as a red oil and used in the above reaction. Yield 0.8 g (74%). RF = 0.20 (toluene: ethanol = 1: 2).

Beispiel 3Example 3

2-(5-Hydroxy-lH-indol-3-yl)-3-(lH-indol-3-yl)maleinimid2- (5-hydroxy-lH-indol-3-yl) -3- (lH-indol-3-yl) maleimide

0,15 g (0,34 mmol) 2-(5-Benzyloxy-lH-indol-3-yl)-3-(lH-indol-3-yl)maleinimid und 4,0g (34 mmol) Pyridinium Hydrochlorid werden unter Stickstoff 1 Stunde auf 150'C erhitzt. Nach dem Abkühlen wird die Reaktionsmischung mit Eiswasser verdünnt und mit Essigester extrahiert. Die organische Phase wird mit Wasser ausgewaschen und zur Trockene eingeengt. Der feste Rückstand wird mit wenig Wasser verrührt, abgesaugt und im Vakuum bei 0,1 Torr / 80*C getrocknet. Man erhält 85 mg (73%) dunkelrotes Produkt vom Schmelzpunkt 200-205'C. RF =· 0,29 (Toluol/Ethanol = 10:2).0.15 g (0.34 mmol) of 2- (5-benzyloxy-1H-indol-3-yl) -3- (1H-indol-3-yl) -maleimide and 4.0 g (34 mmol) of pyridinium hydrochloride are added Nitrogen heated to 150'C for 1 hour. After cooling, the reaction mixture is diluted with ice-water and extracted with ethyl acetate. The organic phase is washed with water and concentrated to dryness. The solid residue is stirred with a little water, filtered off and dried in vacuo at 0.1 Torr / 80 * C. This gives 85 mg (73%) dark red product of melting point 200-205'C. RF = · 0.29 (toluene / ethanol = 10: 2).

Beispiel 4Example 4

2-(5-Benzyloxy-lH-indol-3-yl)-3-(iH-indol-3-yl)maleinimid2- (5-benzyloxy-lH-indol-3-yl) -3- (iH-indol-3-yl) maleimide

0,7 g (1,6 mmol) 2-(5-Benzyloxy-lH-indol-3-yl)-3-(lH-indol-3-yl)maleinsäureanhydrid und 9,5 g Ammoniumacetat werden 30 min. auf 140*C erhitzt. Nach dem Abkühlen wird die Reaktionsmischung mit Wasser verrührt, der ausgefallene Niederschlag wird abgesaugt, gut mit Wasser ausgewaschen und im Vakuum bei 0,1 Torr / 80¹C getrocknet. Man erhält 0,54 g (78%) orangefarbenes0.7 g (1.6 mmol) of 2- (5-benzyloxy-1H-indol-3-yl) -3- (1H-indol-3-yl) maleic anhydride and 9.5 g of ammonium acetate are added for 30 min. heated to 140 * C. After cooling, the reaction mixture is stirred with water, the precipitate is filtered off with suction, washed well with water and dried in vacuo at 0.1 Torr / 80 ¹ C. 0.54 g (78%) of orange is obtained

-19--19-

Produkt vom Schmelzpunkt 308-312'C. RF = 0,29 (Hexan:Ethylacetat = 1:1).Product of melting point 308-312'C. RF = 0.29 (hexane: ethyl acetate = 1: 1).

Das als Ausgangsmaterial verwendete 2-(5-Benzyloxy-lH-indol-3-yl)-3-(lH-indol-3-yl)maleinsäureanhydrid wird wie folgt hergestellt:The starting 2- (5-benzyloxy-1H-indol-3-yl) -3- (1H-indol-3-yl) maleic anhydride is prepared as follows:

•Eine Lösung von 1,0 g (1,83 mmol) 2-(5-Benzyloxy-lH-indol-3-ylJ-S-fl-tert.-butoxycarbonyl-lH-indol-S-ylJ-N-methylmaleinimid in 100 ml 10%iger Kaliumhydroxidlösung (Methanol/Wasser 1+1) wird 1 Stunde unter Rückfluß erhitzt. Nach dem Abkühlen wird die Reaktionsmischung vorsichtig mit halbkonz. Salzsäure angesäuert, wobei ein roter Niederschlag ausfällt. Der Niederschlag wird abgesaugt, gut mit Wasser ausgewaschen und an der Luft getrocknet. Man erhält 0,7 g (87%) orangefarbenes Produkt, Schmelzpunkt 236*C. RF = 0,43 (Hexan:Ethylacetat = l:i).A solution of 1.0 g (1.83 mmol) of 2- (5-benzyloxy-lH-indol-3-ylJ-S-fl-tert-butoxycarbonyl-1H-indol-S-ylJ-N-methylmaleimide in 100 ml of 10% strength potassium hydroxide solution (methanol / water 1 + 1) is refluxed for 1 hour After cooling, the reaction mixture is carefully acidified with half-concentrated hydrochloric acid, whereupon a red precipitate precipitates out The precipitate is filtered off with suction, washed well with water and washed dried in air, giving 0.7 g (87%) of an orange product, mp 236 ° C., RF = 0.43 (hexane: ethyl acetate = 1: 1).

Das als Ausgangsmaterial verwendete 2-(5-Benzyloxy-lH-indol-3-yl)-3-(1-tert.-butoxycarbonyl-lH-indol-3-yl)-N-methylmaleinimid wird wie folgt hergestellt:The starting 2- (5-benzyloxy-1H-indol-3-yl) -3- (1-tert-butoxycarbonyl-1H-indol-3-yl) -N-methylmaleimide is prepared as follows:

Eine Lösung von 20 mmol Ethylmagno&iumbromid in 30 ml 0 Tetrahydrofuran wird mit einer Lösung von 4,46 g (20 mmol) 5-Benzyloxyindol in 20 ml Tetrahydrofuran versetzt. Man hält die Reaktionsmischung 1 Stunde bei 50*C und tropft dann innerhalb Stunde eine Lösung von 3,0 g (7,4 mmol) 2-Brom=3-[1-tert.-butoxycar'jonyl-lH-indol-3-yl ] -N-raethylmaleinimid (Tetrahedron 44, 1988, 2887) in 40 ml Tetrahydrofuran hinzu. Man erhitzt 2 Stunden unter Rückfluß, läßt abkühlen und versetzt die Reaktionsraischung mit einer gesättigten Lösung von Ammoniumchlorid in Wasser. Man extrahiert die Reaktionsprodukte mit Essigester,'trocknet die organische Phase über Natriumsulfat und engt zur Trockene ein. Der Rückstand wird an Kieselgel¹. (Merck Art. 7734) flash chromatographiert, als Elutionsnittel wird Dichlonaethan verwendet. Nach Elution von nicht umgesetztem Ausgangsmaterial wird das gewünschte Produkt durch Einengen der entsprechenden Fraktionen und Verrühren des roten Rückstandes mit wenig Toluol erhalten. Man isoliert 1,3 g (32%) rote Kristalle vom Schmelzpunkt 123*C.To a solution of 20 mmol of ethylmagnomide in 30 ml of tetrahydrofuran is added a solution of 4.46 g (20 mmol) of 5-benzyloxyindole in 20 ml of tetrahydrofuran. The reaction mixture is kept at 50 ° C. for 1 hour and then a solution of 3.0 g (7.4 mmol) of 2-bromo = 3- [1-tert-butoxy-carjonyl-1H-indole-3] is added dropwise within one hour. yl] -N-ethylaluminum imide (Tetrahedron 44, 1988, 2887) in 40 ml of tetrahydrofuran. The mixture is refluxed for 2 hours, allowed to cool and the reaction mixture is mixed with a saturated solution of ammonium chloride in water. The reaction products are extracted with ethyl acetate, the organic phase is dried over sodium sulfate and concentrated to dryness. The residue is chromatographed on silica gel ¹ . (Merck Art. 7734) flash chromatographed, as eluent is used Dichlonaethan. After elution of unreacted starting material, the desired product is obtained by concentrating the appropriate fractions and stirring the red residue with a little toluene. 1.3 g (32%) of red crystals of melting point 123 * C are isolated.

Beispiel 5Example 5

2,3-Bis(5-methoxy-lH-indol-3-yl)maleinimid2,3-bis (5-methoxy-lH-indol-3-yl) maleimide

Eine Lösung von 22 mmol Ethylmagnesiumbromid in 30 ml Tetrahydrofuran wird bei Raumtemperatur mit einer Lösung von · 2,8 g (19 mmol) 5-Methoxyindol in 50 ml Toluol versetzt und 1 Stunde bei Raumtemperatur gerührt. Unter Stickstoff tropft man dann eine Lösung von 1,5 g (5,8 mmol) Dibrommaleinimid in 20 ml Tetrahydrofuran / 50 ml Toluol hinzu und erhitzt 20 Stunden unter Rückfluß. Nach dem Abkühlen wird die ReaktionsmischungA solution of 22 mmol of ethylmagnesium bromide in 30 ml of tetrahydrofuran is treated at room temperature with a solution of 2.8 g (19 mmol) of 5-methoxyindole in 50 ml of toluene and stirred for 1 hour at room temperature. A solution of 1.5 g (5.8 mmol) of dibromomaleimide in 20 ml of tetrahydrofuran / 50 ml of toluene is then added dropwise under nitrogen, and the mixture is refluxed for 20 hours. After cooling, the reaction mixture

xO mit einer gesättigten Lösung von Ammoniumchlorid in Wasser zersetzt, die Produkte werden mit Essigester extrahiert und die organische Phase über Natriumsulfat getrocknet. Nach dem Einengen wird der rote Rückstand mit wenig Methanol verrieben, das ausgefallene rote Produkt wird abgesaugt und im Vakuum bei 0,1 Torr und 100⁰C getrocknet. Man erhält 0,9 g (36%) rote Kristalle, Schmelzpunkt 336⁰C unt=r Zersetzung. RF = 0,30 (Toluol:Ethanol = 10:2).xO is decomposed with a saturated solution of ammonium chloride in water, the products are extracted with ethyl acetate and the organic phase dried over sodium sulfate. After concentration, the red residue is triturated with a little methanol, the precipitated red product is filtered off and dried in vacuo at 0.1 Torr and 100 ⁰ C. This gives 0.9 g (36%) of red crystals, melting point 336 ⁰ C unt = r decomposition. RF = 0.30 (toluene: ethanol = 10: 2).

Beispiel 6 Example 6

2-(lH-Indol-3-yl)-3-(5,6-methylendioxy-lH-indol-3-yl)maleinimid2- (lH-indol-3-yl) -3- (5,6-methylenedioxy-lH-indol-3-yl) maleimide

0,8 g (= 2,1 mmol) 2-(lH-Indol-3-yl)-3-(5,6-methylendioxy-lH-indol-3-yl)-maleinsäureanhydrid werden zusammen mit 20 g Aumoniumacetat lh auf 140⁰C (= Schmelze) erhitzt. Nach dem Abkühlen versetzt man mit 150 ml Wasser und saugt den rotbraunen Niederschlag ab. Zur Reinigung wird an Kieselgel mit CH₂Cl₂ : EtOAa =3:1 als Laufmittel chromatographiert.0.8 g (= 2.1 mmol) of 2- (1H-indol-3-yl) -3- (5,6-methylenedioxy-1H-indol-3-yl) -maleic anhydride are added together with 20 g of ammonium acetate 1 h 140 ⁰ C (= melt) heated. After cooling, 150 ml of water are added and the red-brown precipitate is filtered off with suction. For purification is chromatographed on silica gel with CH ₂ Cl ₂ : EtOAa = 3: 1 as the eluent.

Man erhält 0,40 g (= 45% d. Th.) 2-(lH-Indol-3-yl)-3-(5,6-methylendioxy-lH-indol-3-yl)maleinimid als rote Kristalle vom Schmp. 150°C (Zers.) und RF = 0.4 (CH₂Cl₂:Et0Ac = 3:1).This gives 0.40 g (= 45% of theory) of 2- (1H-indol-3-yl) -3- (5,6-methylenedioxy-1H-indol-3-yl) maleimide as red crystals of mp 150 ° C (dec.) And RF = 0.4 (CH ₂ Cl ₂ : EtOAc = 3: 1).

Das als Ausgangsmaterial verwendete 2-(lH-Indol-3-yl)-3-(5,6-methylendioxy-lH-indol-3-yl)maleinsäureanhydrid wird wie folgt hergestellt:The starting 2- (1H-indol-3-yl) -3- (5,6-methylenedioxy-1H-indol-3-yl) maleic anhydride is prepared as follows:

4,0 g (= 10,4 nunol) 2-(lH-Indol-3-yl)-3-(5,6-methylendioxy-lH-indol-3-yl)-N-methylmaleinimid werden zusammen mit einer Lösung von ICO g KOH in 1600 ml Wasser 30 min am Rückfluß erhitzt. Die • zuerst rote Suspension geht dabei in eine braune Lösung über. Man läßt abkühlen, säuert mit konz. HCl an und saugt den roten Niederschlag ab.4.0 g (= 10.4 mmol) of 2- (1H-indol-3-yl) -3- (5,6-methylenedioxy-1H-indol-3-yl) -N-methylmaleimide are added together with a solution of ICO g KOH heated in 1600 ml of water for 30 min at reflux. The red suspension first turns into a brown solution. It is allowed to cool, acidified with conc. HCl and sucks off the red precipitate.

..0 Man erhält 3,40 g (= 88% d. Th.) 2-(lH-Indol-3-yl) -3-(5,6-methylendioxy-lH-indol-3-yl)-maleinsäureanhydrid, hellrote Kristalle (aus Methanol) vom Schmp. « 200*C (Zers.) und RF = 0.70 (CH₂Cl₂ ! EtOAc = 3:1).0.40 g (= 88% of theory) of 2- (1H-indol-3-yl) -3- (5,6-methylenedioxy-1H-indol-3-yl) -maleic acid anhydride are obtained. bright red crystals (from methanol) of mp. "200 * C (dec.) and RF = 0.70 (CH ₂ Cl ₂ ! EtOAc = 3: 1).

Das als Ausgangsmaterial verwendete 2-(lH-Indol-3-yl)-3-(5,6-raethylendioxy-lH-indol-3-yl)-N-methylmaleinimid wird wie folgt hergestellt:The starting 2- (1H-indol-3-yl) -3- (5,6-ethylenedioxy-1H-indol-3-yl) -N-methylmaleimide is prepared as follows:

8,06 g (= 50 nunol) 5,6-Methylendioxyindol werden in 400 ml Toluol gelöst und bei 60'C mit 25 ml einer 2 M Lösung von EtMgBr in THF (Aldrich) versetzt. Nach 1 h bei 60*C tropft man eine Lösung von 8,1 g (=20 mmol) 2-Brom-3-(l-tert.-butyloxycarbonyl-lH-indol-3-yl)-N-methylmaleinimid in 100 ml Toluol hinzu und erhitzt 3h am Rückfluß. Nach dem Abkühlen auf Raumtemperatur hydrolysiert man durch Zugabe von ICO ml ges. Ammoniumchlorid-Lösung. Man trennt die org. Phase ab, schüttelt die wäßrige Phase mit Essigester aus, löst die Rückstände in Essigester, trocknet die vereinigten organischen Phasen, engt ein und chromatographiert den Rückstand an 600 g Kieselgel mit CH₂Cl₂ : EtOAc =3:1 als Laufmittel.8.06 g (= 50 mmol) of 5,6-methylenedioxyindole are dissolved in 400 ml of toluene and treated at 60 ° C. with 25 ml of a 2 M solution of EtMgBr in THF (Aldrich). After 1 h at 60 ° C., a solution of 8.1 g (20 mmol) of 2-bromo-3- (1-tert-butyloxycarbonyl-1H-indol-3-yl) -N-methylmaleimide in 100 ml is added dropwise Added toluene and heated for 3h at reflux. After cooling to room temperature is hydrolyzed by the addition of ICO ml sat. Ammonium chloride solution. One separates the org. Phase, the aqueous phase is extracted with ethyl acetate, the residue is dissolved in ethyl acetate, the combined organic phases are dried, concentrated and the residue is chromatographed on 600 g of silica gel with CH ₂ Cl ₂ : EtOAc = 3: 1 as the eluent.

Man isoliert 3,75 g 5,6-Methylendioxyindol vom Schmp. 104-106*C, 0,55 g 2-Brora-3-(lH-indol-3-yl)-N-methylmaleinimid und 7,27 g (94 % d.Th.j von 2-(lH-indol-3-yl)-3-(5,6-methylendioxylH-indol-3-yl)-N-methylmaleinimid als rote Kristalle vom Schmp. 140*C (Zers.) und RF = 0,6 (CH₂Cl₂ : EtOAc = 3:1).3.75 g of 5,6-methylenedioxyindole of the mp 104-106 * C, 0.55 g of 2-bromo-3- (1H-indol-3-yl) -N-methylmaleimide and 7.27 g (94 % of theory of 2- (1H-indol-3-yl) -3- (5,6-methylenedioxylH-indol-3-yl) -N-methylmaleimide as red crystals of mp 140 * C (calc. ) and RF = 0.6 (CH ₂ Cl ₂ : EtOAc = 3: 1).

~²²" Beispiel 7~ ²² "Example 7

2-(lH-Indol-3-yl)-3-(5_/6-dimethoxy-lH-indol-3-yl)maleinimid2- (1H-Indol-3-yl) -3- (5 _/ 6-dimethoxy-1H-indol-3-yl) -maleimide

3,0 g (=: 7,72 mmol) 2-(lH-indol-3-yl)-3-(5,6-Dimethoxy-lH-indol-3-yl)maleinsäureanhydrid werden zusammen mit 75 g 'Ammoniumacetat 1 h auf 140'C erhitzt. Nach dem Abkühlen versetzt man mit 1,5 1 Wasser und saugt den dunkelroten Niederschlag ab. Man erhält 2,61 g Rohausbeute. Zur Reinigung werden davon 1 "S g an Kieselgel mit CH₂Cl₂ : EtOAc =8:1 als Laufmittel chromatographiert.3.0 g (= 7.72 mmol) of 2- (1H-indol-3-yl) -3- (5,6-dimethoxy-1H-indol-3-yl) maleic anhydride are added together with 75 g of ammonium acetate 1 h heated to 140'C. After cooling, it is mixed with 1.5 1 of water and sucks off the dark red precipitate. This gives 2.61 g crude yield. For this purpose, 1 "S g of silica gel with CH ₂ Cl ₂ : EtOAc = 8: 1 as the eluent chromatographed.

Man erhält 1,20 g 2-(lH-indol-3-yl)-3-(5,6-Dimethoxy-lH-indol-3-yl)maleinimid · 1/2 EtOAc als dunkelrote Kristalle vom Schmp. 120'C (Zers.) und RF = 0.32 (CH₂Cl₂ : EtOAc = 3:1). Ausbeute: 54% d. Th.1.20 g of 2- (1H-indol-3-yl) -3- (5,6-dimethoxy-1H-indol-3-yl) -maleimide-1/2-EtOAc are obtained as dark red crystals of melting point 120 ° C. (Dec.) And RF = 0.32 (CH ₂ Cl ₂ : EtOAc = 3: 1). Yield: 54% d. Th.

Das als Ausgangsmaterial verwendete 2-(lH-Indol-3-yl)-3-(5,6-dimethoxy-lH-indol-3-yl)maleinsäureanhydrid wird wie folgt hergestellt:The starting 2- (1H-indol-3-yl) -3- (5,6-dimethoxy-1H-indol-3-yl) -maleic anhydride is prepared as follows:

10 g (= 25 mmol) 2-(lH-indol-3-yl)-3-(5,6-dimethoxy lH-indol-3-yl)-N-methylmaleinimid werden in 4000 ml 10%iger KOH 30 min am Rückfluß erhitzt. Die zuerst rote Suspension geht dabei in eine 0 braune Lösung über. Nach dem Abkühlen säuert man mit konz. HCl an und saugt dem roten Niederschlag ab. Man erhitzt den Niederschlag in Methanol und filtriert.10 g (= 25 mmol) of 2- (1H-indol-3-yl) -3- (5,6-dimethoxy-1H-indol-3-yl) -N-methylmaleimide are dissolved in 4000 ml of 10% KOH for 30 min Reflux heated. The first red suspension turns into a brown solution. After cooling, acidify with conc. HCl and sucks off the red precipitate. The precipitate is heated in methanol and filtered.

Man erhält 8,48 g 2-(lH-Indol-3-yl)-3-(5,6-dimethoxy lH-indol-3-yl)maleinsäureanhydrid (= 87,6 % d.Th.) als dunkelrote Kristalle vom Schmp. « 320*C (Zers.) und RF = 0.50 (CH₂Cl₂ : EtOAc = 3:1).This gives 8.48 g of 2- (1H-indol-3-yl) -3- (5,6-dimethoxy-1H-indol-3-yl) maleic anhydride (= 87.6% of theory) as dark red crystals of Mp 320 * C (dec.) And RF = 0.50 (CH ₂ Cl ₂ : EtOAc = 3: 1).

Das als Ausgangsmaterial verwendete 2-(lH-Indol-3-yl)-3-(5,6-dimethoxy-lH-indol-3-yl)-N-methylmaleinimid wird wie folgt hergestellt:The starting 2- (1H-indol-3-yl) -3- (5,6-dimethoxy-1H-indol-3-yl) -N-methylmaleimide is prepared as follows:

22,15 g (= 0,125 m) 5,6-Dimethoxyindol werden in 1000 ml Toluol gelöst und bei 40'C mit 62,5 ml einer 2 M Lösung von EtMgBr in22.15 g (= 0.125 m) of 5,6-dimethoxyindole are dissolved in 1000 ml of toluene and at 40'C with 62.5 ml of a 2 M solution of EtMgBr in

THF (Aldrich) versetzt. Nach 1 h bei 60*C tropft man eine Lösung von 20,26 g (= 0,05 m) 2-Brom-3-(ltert.butyloxycarbonyl-lH-indol-3-yl)-N-methylmaleinimid in 250 ml Toluol hinzu und erhitzt anschließend 3 h am Rückfluß. Nach dem Abkühlen hydrolysiert man durch Zugabe von ges.THF (Aldrich) spiked. After 1 h at 60 * C is added dropwise a solution of 20.26 g (= 0.05 m) of 2-bromo-3- (tert-butyloxycarbonyl-lH-indol-3-yl) -N-methylmaleimide in 250 ml of toluene and then heated for 3 h at reflux. After cooling, hydrolyzed by addition of sat.

Ammoniumchlorid-Lösung. Der gebildete rote Niederschlag wird abfiltriert und an Kieselgel mit CH₂Cl₂:EtOAc = 10:1 als Laufmittel chromatographiert.Ammonium chloride solution. The resulting red precipitate is filtered off and chromatographed on silica gel with CH ₂ Cl ₂ : EtOAc = 10: 1 as the eluent.

Man isoliert 6,51 g von 2-(lH-Indol-3-yl)-3-(5,6-dimethoxy-lH-IC indol-3-yl)-N-methylmaleinimid (= 32% d.Th.) als rote Kristalle vom Schmp. 258*C und RF = 0.44 (CH₂Cl₂ : EtOAc =3:1) und 7,16 g (« 35 % d.Th.) rote Kristalle der gleichen, aber leicht verunreinigten Verbindung mit dem Schmp. 250-254⁰C.6.51 g of 2- (1H-indol-3-yl) -3- (5,6-dimethoxy-1H-indol-indol-3-yl) -N-methylmaleimide (= 32% of theory) are isolated. as red crystals of mp 258 * C and RF = 0.44 (CH ₂ Cl ₂ : EtOAc = 3: 1) and 7.16 g ("35% of theory) of red crystals of the same but slightly contaminated compound with the M.p. 250-254 ⁰ C.

Beispiel 8Example 8

2,3-Bis-(5,6-methylendioxy-lH-indol-3-yl)raaleinimid2,3-bis- (5,6-methylenedioxy-lH-indol-3-yl) raaleinimid

6,44 g (= 40 mmol) 5,6-Methylendioxyindol werden in 300 ml abs. Toluol gelöst und bei 60°C tropfenweise mit 20 ml einer 2 M Lösung von EtMgBr in THF (Aldrich) versetzt. Nach beendeter Zugabe tropft man eine Lösung von 1,7 g (= 6,67 mmol) 0 Dibrommaleinimid in 50 ml Toluol (unter Zusatz der zur Lösung benötigten Minimalmenge an abs. THF) hinzu und erhitzt 18 h am Rückfluß. Nach dem .Abkühlen versetzt man mit ges. Ammoniumchlorid-Lösung, trennt die organische Phase 3b, extrahiert die wäßr. Phase 3 mal mit Toluol und 1 mal mit Essigester. Die vereinigten org. Phasen werden getrocknet, einrotiert und an Kieselgel chromatographiert (Laufmittel: CH₂Cl₂: EtOAc = 30:1) .6.44 g (= 40 mmol) of 5,6-methylenedioxyindole are dissolved in 300 ml of abs. Dissolved toluene and treated dropwise at 60 ° C with 20 ml of a 2 M solution of EtMgBr in THF (Aldrich). After the addition has ended, a solution of 1.7 g (= 6.67 mmol) of 0-dibromomaleimide in 50 ml of toluene (with the addition of the minimum amount of absolute THF required for the solution) is added dropwise and the mixture is heated at reflux for 18 hours. After the .Cooling mixed with ges. Ammonium chloride solution, separating the organic phase 3b, extracts the aq. Phase 3 times with toluene and once with ethyl acetate. The united org. Phases are dried, concentrated by rotary evaporation and chromatographed on silica gel (mobile phase: CH ₂ Cl ₂ : EtOAc = 30: 1).

Man isoliert 1,27 g (= 56 % d.Th.) 2-Brom-3-(5,6-methylendioxylH-indol-3-yl)maleinimid vom Schmp. « 185"C (Zers.) und RF = 0.50 (CH₂Cl₂ : EtOAc = 3:1) und 0,63 g (= 22,5% d.TH) 2,3-Bis(5,6-methylendioxy-lH-indol-3-yl)maleinimid als rote Kristalle vom Schmp. « 270*C (Zers.) (aus Propanol) und RF = 0.36 (CH₂C₁₂ : EtOAc = 3:1).1.27 g (= 56% of theory) of 2-bromo-3- (5,6-methylenedioxyH-indol-3-yl) maleimide of the mp "185" C (dec.) And RF = 0.50 are isolated (CH ₂ Cl ₂ : EtOAc = 3: 1) and 0.63 g (= 22.5% d.TH) of 2,3-bis (5,6-methylenedioxy-1H-indol-3-yl) maleimide as red Crystals of mp. "270 * C (dec.) (From propanol) and RF = 0.36 (CH ₂ C ₁₂ : EtOAc = 3: 1).

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Beispjel 9 Beispjel 9

2,3-Bis-(lH-indol-3-yl)maleinimid wurde nach Literatur (Tetrahedron 44, 1988, 2887) e.vhalten.2,3-Bis (1H-indol-3-yl) maleimide was obtained according to literature (Tetrahedron 44, 1988, 2887).

Beispiel 10Example 10

2-(6-Hydroxy-lH-indol-3-yl)-3-(lH-indol-3-yl)maleinimid wurde nach Literatur (Tetrahedron 44, 1988, 2887) erhalten.2- (6-Hydroxy-1H-indol-3-yl) -3- (1H-indol-3-yl) -maleimide was obtained according to literature (Tetrahedron 44, 1988, 2887).

In analoger Weise zu den Beispielen 1 bis 10 und den angegebenen Verfahren erhält man:In a manner analogous to Examples 1 to 10 and the indicated processes, the following are obtained:

11.) 2-(5-Benzyloxy-lH-indol-3-yl)-3-[l-(3-dimethylaminopropyl)-lH-indol-3-yl]maleinimid, 188-189⁰C;11) 2- (5-benzyloxy-lH-indol-3-yl) -3- [l- (3-dimethylaminopropyl) -lH-indol-3-yl] maleimide, 188-189 ⁰ C;

12.) 2-[5-Benzyloxy-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)maleinimid, 240-241*C;12.) 2- [5-Benzyloxy-1- (3-dimethylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) maleimide, 240-241 * C;

13.) 2-(5-Methoxy-lH-indol-3-yl)-3-[5-methoxy-l-(3-dimethylaminopropyl)-lH-indol-3-yl]maleinimid, 250-251⁰C;13) 2- (5-methoxy-lH-indol-3-yl) -3- [5-methoxy-l- (3-dimethylaminopropyl) -lH-indol-3-yl] maleimide, 250-251 ⁰ C;

14.) (±)-2-(lH-Indol-3-yl)-3-[l-(3-dimethylamino-2-methoxypropyl)-lH-indol-3-yl]maleinimid, 218*C, Zers.;14.) (±) -2- (1H-Indol-3-yl) -3- [1- (3-dimethylamino-2-methoxypropyl) -1H-indol-3-yl] maleimide, 218 * C, dec. ;

15.) 2-(lH-Indol-3-yl)-3-[5-(3-dimethylaminopropyloxy)-IH-indol-3-yl]maleinimid, 235*C;15.) 2- (1H-Indol-3-yl) -3- [5- (3-dimethylaminopropyloxy) -1H-indol-3-yl] maleimide, 235 * C;

16.) 2,3-Bis-(5-fluor-lH-indol-3-yl)maleinimiJ_/ 320*C, Zers.;16.) 2,3-Bis (5-fluoro-1H-indol-3-yl) maleimide _/ 320 * C, Zers .;

17.) 2-(5-Fluor-lH-indoi-3-yl)-3-[5-fluor-l-(3-dimethylaminopropyl)-lH-indol-3-yl]maleinimid, 283-285'C;17.) 2- (5-Fluoro-1H-indol-3-yl) -3- [5-fluoro-1- (3-dimethylaminopropyl) -1H-indol-3-yl] maleimide, 283-285 ° C;

18.) 2,3-Bis-(5-benzyloxy-lH-indol-3-yl)maleinimid, 130*C, Zers.;18.) 2,3-Bis (5-benzyloxy-1H-indol-3-yl) maleimide, 130 * C, Zers .;

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19.) 2-(5-Benzyloxy-lH-indol-3-yl)-3-[5-benzyloxy-l-(3-dimethylaminopropyl-lH-indol-3-yl]maleinimid, 277*C, Zers.;19.) 2- (5-Benzyloxy-1H-indol-3-yl) -3- [5-benzyloxy-1- (3-dimethylaminopropyl-1H-indol-3-yl] -maleimide, 277 * C, Zers .;

20.) 2-(5-Benzyloxy-l-methyl-lH-indol-3-yl)-3-(l-methyl-lH-indol-3-yl)maleinimid;20.) 2- (5-Benzyloxy-1-methyl-1H-indol-3-yl) -3- (1-methyl-1H-indol-3-yl) -maleimide;

21.) 2-[5-Benzyloxy-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-3-(l-methyl-lH-indol-3-yl)maleinimid, 181-182"C;21.) 2- [5-Benzyloxy-1- (3-dimethylaminopropyl) -1H-indol-3-yl] -3- (1-methyl-1H-indol-3-yl) maleimide, 181-182 ° C;

22.) 2,3-Bis-(5-chlor-lH-indol-3-yl)maleinimid, 279-281'C, Zers.;22.) 2,3-Bis (5-chloro-1H-indol-3-yl) maleimide, 279-281'C, Zers .;

23.) 2-(5-Chlor-lH-indol-3-yl)-3-[5-chlor-l-(3-dimethylaminopropyl)-lH-indol-3-yl]maleinimid, 255-257"C, Zers.;23.) 2- (5-chloro-1H-indol-3-yl) -3- [5-chloro-1- (3-dimethylaminopropyl) -1H-indol-3-yl] maleimide, 255-257 ° C, dec .;

24.) 2,3-Bis-(5-methyl-lH-indol-3-yl)maleinimid, 180°C, Zers.;24.) 2,3-Bis (5-methyl-1H-indol-3-yl) maleimide, 180 ° C, Zers .;

25.) 2-(5-Methyl-lH-indol-3-yl)-3-[5-methyl-l-(3-dimethylaminopropyl)-lH-indo]-3-yl]maleinimid, 215°C;25.) 2- (5-Methyl-1H-indol-3-yl) -3- [5-methyl-1- (3-dimethylaminopropyl) -1H-indo] -3-yl] maleimide, 215 ° C;

26.) 2,3-Bis-(5-brom-lH-indol-3-yl)maleinimid, 351⁰C;26) 2,3-bis (5-bromo-lH-indol-3-yl) maleimide, 351 ⁰ C;

27.) 2-(5-Brom-lH-indol-3-yl)-3-[5-brom-l-(3-dimethylaminopropyl)-lH-indol-3-yl]maleinimid, 257-258⁰C;27) 2- (5-bromo-lH-indol-3-yl) -3- [5-bromo-l- (3-dimethylaminopropyl) -lH-indol-3-yl] maleimide, 257-258 ⁰ C;

28.) 2-(lH-Indol-3-yl)-3-[l-(3-dimethylaminoethyl)-lH-indol-3-yl]-maleinimid, hellrote Kr., 246-248*C, zers., hergestellt nach Verfahren C.28.) 2- (1H-indol-3-yl) -3- [1- (3-dimethylaminoethyl) -lH-indol-3-yl] -maleimide, bright red Kr., 246-248 * C, decomp., prepared according to method C.

29.) 2-(lH-Indol-3-yl)-3-[l-(3-(l-piperidino)propyl)-lH-indol-3-yl]-maleinimid, hellorange Kr., 2O4'C hergestellt nach Verfahren C.29.) 2- (1H-Indol-3-yl) -3- [1- (3- (1-piperidino) propyl) -1H-indol-3-yl] -maleimide, light orange Kr., 2O4'C according to method C.

30.) 2-(lH-Indol-3-yl)-3-[l-(3-(4-morpholino)propyl)-lH-inclol-3-yl]-malei amid, hellorange Kr., 285-287*C, zers., hergestellt nach Verfahren C.30.) 2- (1H-Indol-3-yl) -3- [1- (3- (4-morpholino) propyl) -1H-inclol-3-yl] -maleimide, light orange Kr., 285-287 * C, decomp., Prepared according to method C.

31.) 2-[l-(3-Diethylaminopropyl)-iH-indul-3->l]-3-(UI-indol-3-yl)-maleinimid, hellorange Kr., 241-242'C, zers., hergestellt nach Verfahren C.31.) 2- [1- (3-diethylaminopropyl) -iH-indul-3-> 1] -3- (UI-indol-3-yl) -maleimide, light orange Kr., 241-242 ° C, calc. prepared according to method C.

2.) (±)-2-[l-(3-Diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid, dunkelrote Kr., 158'C, hergestellt nach Verfahren C unter Verwendung von 1,1-Diethyl-3-hydroxyazet.idiniumchlorid als Alkylierungsmittel,.2.) (±) -2- [1- (3-diethylamino-2-hydroxypropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide, dark red Kr., 158 'C, prepared by Method C using 1,1-diethyl-3-hydroxyacetyl chloride as the alkylating agent.

33.) 2-(5-Methoxy-lH-indol-3-yl)-3-[l-(3-dimethylaminopropyl)-LO lH-indol-3-yl]-maleinimid, hellorange Kr., 224-225^eC, hergestellt nach Verfahren C unter Verwendung der SEM-Schutzgruppe.33.) 2- (5-Methoxy-1H-indol-3-yl) -3- [1- (3-dimethylaminopropyl) -LO 1 H-indol-3-yl] -maleimide, light orange Kr., 224-225 ^e C, prepared by Method C using the SEM protecting group.

34.) 2-(lH-Indol-3-yl)-3-[5-methoxy-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid, hellrote Kr., 234-236*C, hergestellt nach Verfahren B unter Verwendung der SEM-Schutzgruppe.34.) 2- (1H-Indol-3-yl) -3- [5-methoxy-1- (3-dimethylaminopropyl) -1H-indol-3-yl] -maleimide, light red Kr., 234-236 * C prepared according to Method B using the SEM protecting group.

35.) (±)-2-[l-(2,3-Dihydroxypropyl)-lH-indol-3~yl]-3-(lH-indol-3-yl)-maleinimid, dunkelrote Kr., 135*C, hergestellt nach Verfahren B unter Verwendung der BOC-Schutzgruppe und Epibromhydrin als Alkylierungsmittel.35.) (±) -2- [1- (2,3-Dihydroxypropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide, dark red Kr., 135 * C prepared according to Method B using the BOC protecting group and epibromohydrin as the alkylating agent.

36.) 2"(5-Methoxy-lH-indol-3-yl)-3-[l-(j-(4-morpholino)propyl)-lH-indol-3-yl]-maleinimid und36.) 2 "(5-methoxy-1H-indol-3-yl) -3- [1- (j- (4-morpholino) propyl) -1H-indol-3-yl] -maleimide and

37.) 2-(lH-Indol-3-yl)-3-[5-methoxy-l-(3-(4-morpholino)-propyl)-lH-indol-3-yl]-maleinimid, als Regioisomerenmischung im Verhältnis 1:1, orangefarb. Kr., 132-135'C, hergestellt nach Verfahren B unter Verwendung der BOC-Schutζgruppe.37.) 2- (1H-Indol-3-yl) -3- [5-methoxy-1- (3- (4-morpholino) -propyl) -1H-indol-3-yl] -maleimide, as a regioisomeric mixture in the 1: 1 ratio, orange. Kr., 132-135'C, prepared according to Method B using the BOC protection group.

38.) (±)-2-[l-(3-Ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid, dunkelrote Kr., 130-134'C erhalten nach Verfahren B unter Verwendung der BOC-Schutzgruppe und Epibromhydrin als Alkylierungsmittel.38.) (±) -2- [1- (3-Ethoxy-2-hydroxypropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide, dark red Kr., 130 -134'C obtained by Method B using the BOC protecting group and epibromohydrin as the alkylating agent.

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39.) (±)-2-[l-(2-Hydroxy-3-(l-piperidino)-propyi)-lri-indol-3~ yl]-3-(lH-indol-3-yl)-maleinimid, dunkelrote Kr._; 142'C, zers., hergestellt nach Verfahren B unter Verwandung der BOC-Schutzgruppe und Epibromhydrin als Alkylierungsmittel.39.) (±) -2- [1- (2-Hydroxy-3- (1-piperidino) -propyl) -1-indol-3-yl] -3- (1H-indol-3-yl) -maleimide , dark red Kr _.; 142'C, zers., Prepared by method B with the BOC protective group and epibromohydrin as alkylating agent.

40.) (±)-2-[l-(3-Diethylamino-2-hydroxypropyl)-5-methoxy-lH-indol-3-y.\]-3-(lH-indol-3-yi) -maleinimid und40.) (±) -2- [1- (3-Diethylamino-2-hydroxypropyl) -5-methoxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide and

41.) (±)-2-[l-(3-Diethylaraino-2-hydroxypropyl)-lH-indol-3-yl]-3-(5-methoxy-lH-indol-3-yl)-mF.leinimid, air; Regioisomerenmischung im Verhältnis 4:1, dunkelrote Kr., ab 150"C zers., hergestellt nach Verfahren B unter Verwendung der BOC-Schutzgruppe und 1,l-Diethyl-3-hydroxyazetidiniumchlorid als Alkylierr.ngsmittel.41.) (±) -2- [1- (3-diethylaraino-2-hydroxypropyl) -1H-indol-3-yl] -3- (5-methoxy-1H-indol-3-yl) -mF.-imide , air; Regioisomerenmischung in the ratio 4: 1, dark red Kr., From 150 "C zers., Prepared by Method B using the BOC protective group and 1, l-diethyl-3-hydroxyazetidiniumchlorid as Alkylierr.ngsmittel.

42.) 2-(lH-Indol-3-yl)-3-[5-methoxy-l-(3-(l-piperidino)propyl) lH-indol-3-yl]-maleinimid, 257-258*C und zusammen mit42.) 2- (1H-Indol-3-yl) -3- [5-methoxy-1- (3- (1-piperidino) propyl) -1H-indol-3-yl] -maleimide, 257-258 * C and together with

43.) 2-(5-Methoxy-lH-indol-3-yl)-3-[l-(3-(l-piperidino)propyl)-lH-indol-3-yl]-maleinimid, als Regioisomerenmischung im Verhältnis 1:1, orangefarb. Kr., 150*C, hergestellt nach Verfahren B unter Verwendung der BOC-Schutzgruppe.43.) 2- (5-Methoxy-1H-indol-3-yl) -3- [1- (3- (1-piperidino) propyl) -1H-indol-3-yl] -maleimide as a regioisomeric mixture in proportion 1: 1, orange. Kr., 150 * C, prepared by Method B using the BOC protecting group.

44.) 2-[l-(3-Diethylaminopropyl)-5-methoxy-lH-indol-3-yl]-3-(5,6-dimethoxy-l-methyl-lH-indol-3-yl)-maleinimid, hellrote Kr., 165-166'C, hergestellt nach Verfahren A.44.) 2- [1- (3-Diethylaminopropyl) -5-methoxy-1H-indol-3-yl] -3- (5,6-dimethoxy-1-methyl-1H-indol-3-yl) -maleimide , light red Kr., 165-166'C, prepared according to method A.

45.) 2-[l-(3-Diethylaminopropyl)-5-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleiniraid und45.) 2- [1- (3-diethylaminopropyl) -5-methoxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleiniraid and

46.) 2-[l-(3-Diethylaminopropyl)-lH-indol-3-yl)--3-(5-methoxylH-indol-3-yl)-maleinimid, als Regioisomerenmischung im Verhältnis'3:2, hellrote Kr., 206-208'C, zers., hergestellt nach Verfahren B unter Verwendung der BOC-Schutzgruppe.46.) 2- [1- (3-diethylaminopropyl) -1H-indol-3-yl) -3- (5-methoxy-H-indol-3-yl) -maleimide, as a mixture of regioisomers in the ratio 3: 2, light red Kr., 206-208 ° C, produced by Method B using the BOC protecting group.

47.) 2-[l-(3-Diethylaminopropyl)-lH-indol-3-yl]-3-(5-methoxylH-indol-3-yl)-maleinimid und47.) 2- [1- (3-diethylaminopropyl) -1H-indol-3-yl] -3- (5-methoxy-H-indol-3-yl) -maleimide and

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48.) 2-[ 1- (3-Diethylaminopropyl) -S-iaethoxy-IH-indol-S-yl] -3-(lH-indol-3-yl)-maleinimid, als Regioisomerenmischung im Verhältnis 3:1, hellrote Kr., 185-190'C, hergestellt nach Verfahren B.48.) 2- [1- (3-diethylaminopropyl) -S-iethoxy-IH-indol-S-yl] -3- (1H-indol-3-yl) -maleimide, as a regioisomeric mixture in the ratio 3: 1, light red Kr., 185-190'C, prepared according to method B.

49.) 2-[1-(3-Diethylaminopropyl)-5-methoxy-lH-indol-3-yl]-3-(6-methoxy-lH-indol-3-yl)-maleinimid und49.) 2- [1- (3-diethylaminopropyl) -5-methoxy-1H-indol-3-yl] -3- (6-methoxy-1H-indol-3-yl) -maleimide and

50.) 2-[1-(3-Diethylaminopropyl)-6-methoxy-IH-indol-3-yl]-3-(5-methoxy-lH-indol-3-yl)-maleinimid, als Regioisomerenmischung im Verhältnis 5:1, rote Kr., 176-182'C, hergestellt nach Verfahren B.50.) 2- [1- (3-diethylaminopropyl) -6-methoxy-1H-indol-3-yl] -3- (5-methoxy-1H-indol-3-yl) -maleimide, as a regioisomer mixture in a ratio of 5 : 1, red Kr., 176-182'C, prepared according to method B.

51.) 2-[5-Fluor-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid und51.) 2- [5-fluoro-1- (3-dimethylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide and

52.) 2-(5-Fluor-lH-indol-3-yl)-3-[l-(3-dimethylaminoplopyl)-lH-indol-3-yl]-maleinimid, als Regioisomerenmischung im Verhältnis 3:1, 230-235'C.52.) 2- (5-Fluoro-1H-indol-3-yl) -3- [1- (3-dimethylaminoplopyl) -1H-indol-3-yl] -maleimide, as a mixture of regioisomers in the ratio 3: 1, 230 -235'C.

In entsprechender Weise werden die folgenden Verbindungen je nach Wahl der Substituenten nach einem der genannten Verfahren hergestellt:Likewise, depending on the choice of substituents, the following compounds are prepared by one of the following methods:

2-[1-(3-(Amidinothio)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-0 maleinimid;2- [1- (3- (amidinothio) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -0-maleimide;

2-[l-(2-Aminoethyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (2-aminoethyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-Aminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-aminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-tl-(2-Diethylaminoethyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2-tl (2-diethylaminoethyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[1-(3-Ethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (3-ethylaminopropyl) -lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

297990 -29- 297990 -29-

(±)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-lh-indol-3-ylj-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3-dimethylaminopropyl) -lh-indol-3-YLJ-3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(2-hydroxy-3-dimethylaminopropyl) l- -lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

(+.) -2-[l-[2-Hydroxy-3-(4-morpholino)propyl]-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+.) -2- [1- [2-Hydroxy-3- (4-morpholino) propyl] -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[l-[2-Hydroxy-3-(4-morpholino)propyl]-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- [2-hydroxy-3- (4-morpholino) propyl] -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[l-[2-Hydroxy-3-(4-morpholino)propyl]-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [l- [2-hydroxy-3- (4-morpholino) propyl] -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[1-(3-Hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-raaleinimii;2- [1- (3-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) -raaleinimii;

2-(lH-Indol-3-yl)-3-[l-(3-isothiocyanatopropyl)-lH-indol-3-yl] maleinimid;2- (1H-indol-3-yl) -3- [1- (3-isothiocyanatopropyl) -1H-indol-3-yl] -maleimide;

(±)-2-(lH-Indol-3-yl)-3-[l-(2-methoxy-3-dimethylaminopropyl)-].H-indol-3-yl ] -maleinimid ;(±) -2- (1H-indol-3-yl) -3- [1- (2-methoxy-3-dimethylaminopropyl) -]. H-indol-3-yl] -maleimide;

-2-(lH-Indol-3-yl)-3-[l-(2-methoxy-3-dimethylaminopropyl)-IH-indol-3-yl]-maleinimid;-2- (lH-indol-3-yl) -3- [l- (2-methoxy-3-dimethylaminopropyl) -IH-indol-3-yl] -maleimide;

(-)-2-(lH-Indol-3-yl)-3-[l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-raaleinimid;(-) - 2- (lH-indol-3-yl) -3- [l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -raaleinimid;

2-(lH~Indol-3-yl)-3-[l-(3-dimethylaminopropyl)-lH-indol-3-yl] maleinimid;2- (1H-indol-3-yl) -3- [1- (3-dimethylaminopropyl) -1H-indol-3-yl] maleimide;

5 2-(lH-Indol-3-yl)-3-[l-(3-methylaminopropyl)-lH-indol-3-yl]-maleinimid;5 2- (1H-indol-3-yl) -3- [1- (3-methylaminopropyl) -1H-indol-3-yl] -maleimide;

29?9?ο29? 9? Ο

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2-(lH-Indol-3-yl)-3-[l-[3-(2-nitroguaniaino)propyl]-lH-indol-3 yl]-maleinimid;2- (1H-indol-3-yl) -3- [1- [3- (2-nitroguano-1-amino) -propyl] -1H-indol-3-yl] -maleimide;

2-(4-Acetylamino-lH-indol-3-yl)-3-(lH-indol-3-yl)-maleinimid;2- (4-acetylamino-lH-indol-3-yl) -3- (lH-indol-3-yl) maleimide;

. 2-(5-Acetylamino-lH-indol-3-yl)-3-(lH-indol-3-yl)-maleinimid; 2-(6-Acetylamino-lH-indol-3-yl)-3-(lH-indol-3-yl)-maleinimid; 2-(7-Acetylamino-lH-indol-3-yl)-3-(lH--indol-3-yl)-inaleinimid; 2-(4-Amino-lH-indol-3-yl)-3-(lH-indol-3-yl)-maleinimid; 2-(5-Amino-lH-indol-3-yl)-3-(lH-indol-3-yl)-maleinimid; 2-(6-Amino-lH-indol-3-yl)-3-(lH-indol-3-yl)-maleinimid; 2-(7-Amino-lH-indol-3-yl)-3-(lH-indol-3-yl)-maleinimid; 2-(4-Benzyloxy-lH-indol-3~yl)-3-(lH-indol-3-yl)-maleinimid; 2-(5-Benzyloxy-lH-indol-3-yl)-3-(lH-indol-3-yl)-maleinimid; 2-(6-Benzyloxy-lH-indol-3-yl)-3-(lH-indol-3-yl)-maleinimid; 2-(7-Benzyloxy-lH-indol-3-yl)-3-(lH-indol-3-yl)-maleinimid; 2-(4-Brom-lH-indol-3-yl)-3-(lH-indol-3-yl)-maleinimid; 2-(5-Brom-lH-indol-3-yl)-3-(lH-indol-3-yl)-maleinimid; 2-(6-Brom-lH-indol-3-y.l)-3-(lH-indol-3-yl)-maleinimid; 2-(7-Brom-lH-indol-3-yl)-3-(lH-indol-3-yl)-maleinimid; 2-(4-Chlor-lH-indol-3-yl)-3-(lH-indol-3-yl)-maleinimid; 2-(5-Chlor-lH-indol-3-yl)-3-(lH-indol-3-yl)-maleinimid; 2-(6-Chlor-lH-indol-3-yl)-3-(lH-.indol-3-yl)-maleinimid;, 2- (5-acetylamino-lH-indol-3-yl) -3- (lH-indol-3-yl) maleimide; 2- (6-acetylamino-lH-indol-3-yl) -3- (lH-indol-3-yl) maleimide; 2- (7-acetylamino-lH-indol-3-yl) -3- (lH - indole-3-yl) -inaleinimid; 2- (4-amino-lH-indol-3-yl) -3- (lH-indol-3-yl) maleimide; 2- (5-amino-lH-indol-3-yl) -3- (lH-indol-3-yl) maleimide; 2- (6-amino-lH-indol-3-yl) -3- (lH-indol-3-yl) maleimide; 2- (7-amino-lH-indol-3-yl) -3- (lH-indol-3-yl) maleimide; 2- (4-benzyloxy-lH-indol-3 ~ yl) -3- (lH-indol-3-yl) maleimide; 2- (5-benzyloxy-lH-indol-3-yl) -3- (lH-indol-3-yl) maleimide; 2- (6-benzyloxy-lH-indol-3-yl) -3- (lH-indol-3-yl) maleimide; 2- (7-benzyloxy-lH-indol-3-yl) -3- (lH-indol-3-yl) maleimide; 2- (4-bromo-lH-indol-3-yl) -3- (lH-indol-3-yl) maleimide; 2- (5-bromo-lH-indol-3-yl) -3- (lH-indol-3-yl) maleimide; 2- (6-bromo-lH-indol-3-y.l) -3- (lH-indol-3-yl) maleimide; 2- (7-bromo-lH-indol-3-yl) -3- (lH-indol-3-yl) maleimide; 2- (4-chloro-lH-indol-3-yl) -3- (lH-indol-3-yl) maleimide; 2- (5-chloro-lH-indol-3-yl) -3- (lH-indol-3-yl) maleimide; 2- (6-chloro-lH-indol-3-yl) -3- (lH-.indol-3-yl) maleimide;

2--(7-Chlor-lH-indol-3-yl)-3-(lH-indol-3-yl)-iuaieinimid; 2· (4-Fluor-lH-indol-3-yl)-3-(lH-indol-3-yl)-maleinimid; 2-(5-Fluor-lH-indol-3-yl)-3-(lH-indol-3-yl)-maleinimid; 2-(6-Fluor-lH-indol-3-yl) -3-(lH~indol--3-yl) -maleinimid; 2~(7-Fluor-lH-indol-3-yl)-3-(lH-indol-3-yl)-maleinimid; 2-(4-Hydroxy-lH-indol-3-yl)-3-(lH-indol-3-yl)-maleinimid; 2-(5-Hydroxy-lH-indol-3-yl)-3-(lH-indol-3-yl)»maleinimid; 2-(6-Hydroxy-lH-indol-3-yl)-3-(lH-indol-3-yl)»maleinimid; 2-(7-Hydroxy-lH-indol-3-yl)-3-(lH-indol-3-yl)-maleinimid;2 - (7-chloro-lH-indol-3-yl) -3- (lH-indol-3-yl) -iuaieinimid; 2 x (4-fluoro-1H-indol-3-yl) -3- (1H-indol-3-yl) -maleimide; 2- (5-fluoro-lH-indol-3-yl) -3- (lH-indol-3-yl) maleimide; 2- (6-fluoro-1H-indol-3-yl) -3- (1H-indol-3-yl) -maleimide; 2 ~ (7-fluoro-lH-indol-3-yl) -3- (lH-indol-3-yl) maleimide; 2- (4-hydroxy-lH-indol-3-yl) -3- (lH-indol-3-yl) maleimide; 2- (5-hydroxy-lH-indol-3-yl) -3- (lH-indol-3-yl) 'maleimide; 2- (6-hydroxy-lH-indol-3-yl) -3- (lH-indol-3-yl) 'maleimide; 2- (7-hydroxy-lH-indol-3-yl) -3- (lH-indol-3-yl) maleimide;

2-(4-Trifluormethyl-lH-indol-3-yl)-3-(lH-indol-3-yl)-maleinimid;2- (4-trifluoromethyl-lH-indol-3-yl) -3- (lH-indol-3-yl) maleimide;

2-(5-Trifluormethyl-lH-indol-3-yl)-3-(lH-indd-3-yl)-maleinimid;2- (5-trifluoromethyl-lH-indol-3-yl) -3- (lH-indd-3-yl) maleimide;

2-(6-Triflucrmethyl-lH-indol-3-yl)-3-(lH-indol-3-yl)-maleinimid;2- (6-Triflucrmethyl-lH-indol-3-yl) -3- (lH-indol-3-yl) maleimide;

2-(7-Trifluonnethyl-lH-indol-3-yl)-3-(lH-indol-3-yl)-maleinimid;2- (7-Trifluonnethyl-lH-indol-3-yl) -3- (lH-indol-3-yl) maleimide;

2-(lH-Indol-3-yl)-3-(4-methoxy-lH-indol-3-yl)-maleinimid; 2-(lH-Indol-3-yl)-3-(5-methoxy-lH-indol-3-yl)-maleinimid; 2-(lH-Indol-3-yl)-3-(6-methoxy-lH-indol-3-yl)-maleinimid; 2-(lH-Indol-3-yl)-3-(7-methoxy-lH-indol-3-yl)-maleinimid;2- (lH-indol-3-yl) -3- (4-methoxy-lH-indol-3-yl) maleimide; 2- (lH-indol-3-yl) -3- (5-methoxy-lH-indol-3-yl) maleimide; 2- (lH-indol-3-yl) -3- (6-methoxy-lH-indol-3-yl) maleimide; 2- (lH-indol-3-yl) -3- (7-methoxy-lH-indol-3-yl) maleimide;

2-(lH-Indol-3-yl)-3-(4,5-methylendioxy-lH-indol-3-yl)-maleinimid;2- (lH-indol-3-yl) -3- (4,5-methylenedioxy-lH-indol-3-yl) maleimide;

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2-(lH-Indol-3-yl)-3-(5,6-methylendioxy-lH-indol-3-yl)-maleinimid;2- (lH-indol-3-yl) -3- (5,6-methylenedioxy-lH-indol-3-yl) maleimide;

2-(lH-Indol-3-yl)-3-(6, 7-methylendio;ry-lH-indol-3-yl) maleinimid;2- (1H-indol-3-yl) -3- (6,7-methylenedioyl-1H-indol-3-yl) maleimide;

2-(lH-Indol-3-yl)-3-(4-methyl-lH-indol-3-yi)-müleinimid; 2-(lH-Indol-3-yl)-3-(5-methyl-lH-indol-3-yl)-maleinimid; 2-(lH-Indol-3-yl)-3-(6-methyl-lH-indol-3-yl)-maleinimid; 2-(lH-Indol-3-yl)-3-(7-methyl-lH-indol-3-yl)-maleinimid; 2-(lH-Indol-3-yl)-3-(4-nitro-lH-indol-3-yl)-maleinimid; 2-(lH-Indol-3-yl)-3-(5-nitro-lH-indol-3-yl)-maleinimid; 2-(lH-Indol-3-yl)-3-(6-nitro-lH-indol-3-yl)-maleinimid; 2-(lH-Indol-3-yl)-3-(7-nitro-lH-indol-3-yl)-maleinimid?2- (lH-indol-3-yl) -3- (4-methyl-lH-indol-3-yl) -müleinimid; 2- (lH-indol-3-yl) -3- (5-methyl-lH-indol-3-yl) maleimide; 2- (lH-indol-3-yl) -3- (6-methyl-lH-indol-3-yl) maleimide; 2- (lH-indol-3-yl) -3- (7-methyl-lH-indol-3-yl) maleimide; 2- (lH-indol-3-yl) -3- (4-nitro-lH-indol-3-yl) maleimide; 2- (lH-indol-3-yl) -3- (5-nitro-lH-indol-3-yl) maleimide; 2- (lH-indol-3-yl) -3- (6-nitro-lH-indol-3-yl) maleimide; 2- (lH-indol-3-yl) -3- (7-nitro-lH-indol-3-yl) maleimide?

2-(lH-Indol-3-yl)-3-(4-methylthio-lH-indol-3-yl)-maleinimid; 2-(lH-Indol-3-yl)-3-(5-methylthio-lK-indol-3-yl)-maleinimid; 2-(lH-li»ilül-3-yl)-3-(6-methylthio-lH-indol-3-yl) -maleinimid; 2-(lH-Indol-3--yl)-3-(7-methylthio-lH-indol-3-yl)-maleininid; 2-(lH-Indol-3-yl)-3-(4,5-dimethoxy-lH-indol-3-yl)-maleinimid; 2-(lH-Indol-3-yl)-3-(5,6-dimethoxy-lH-indol-3-yl)-maleinimid; 2-(lH-Indol-3-yl)-3-(e,7-dimethoxy-lH-indol-3-yl)-maleinimid;2- (lH-indol-3-yl) -3- (4-methylthio-lH-indol-3-yl) maleimide; 2- (lH-indol-3-yl) -3- (5-methylthio-lK-indol-3-yl) maleimide; 2- (1H-1-indol-3-yl) -3- (6-methylthio-1H-indol-3-yl) -maleimide; 2- (lH-indol-3 - yl) -3- (7-methylthio-lH-indol-3-yl) -maleininid; 2- (lH-indol-3-yl) -3- (4,5-dimethoxy-lH-indol-3-yl) maleimide; 2- (lH-indol-3-yl) -3- (5,6-dimethoxy-lH-indol-3-yl) maleimide; 2- (lH-indol-3-yl) -3- (e, 7-dimethoxy-lH-indol-3-yl) maleimide;

2-[4-Acetylamino-l-(3-(amidinothio)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [4-acetylamino-l- (3- (amidinothio) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

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2-[5-Acetylamino-l-(3-(amidinothio)propyl)-lH-indol-3-yj.]-3-(lH-indol-3-yl)-maleinimid;2- [5-Acetylamino-l- (3- (amidinothio) propyl) -lH-indole-3-yj.] - 3- (lH-indol-3-yl) maleimide;

2-f >' A.-etylamino-l-( 3-(amidinothio) propyl) -lH-indol-3-yl]-3-(lH-indol-3-yl)-maleiniraid;2-f "'A.-etylamino-1- (3- (amidinothio) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleiniraid;

2-[7-Acetylamino-l--( 3-(amidinothio) propyl )-lH-indol-3-yl]-3-. (lH-indol-3-yl)-maleinimid;2- [7-Acetylamino-1- (3- (amidinothio) propyl) -1H-indol-3-yl] -3-. (LH-indol-3-yl) maleimide;

2-[1-(3-(Amidinothio)propyl)-4-amino-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -4-amino-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[1-(3-(Amidinothio)propyl)-5-amino-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -5-amino-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[l-(3-(Amidinothio)propyl)-ö-amino-lH-indol-S-yl]-3-(IH-indol-3-yl)-maleinimid;2- [l- (3- (amidinothio) propyl) -o-amino-lH-indol-S-yl] -3- (IH-indol-3-yl) maleimide;

2-[1-(3-(Amidinothio)propyl)-V-amino-lH-indol-S-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -V-amino-lH-indol-S-yl] -3- (IH-indol-3-yl) maleimide;

2-[l-(3-(Amidinothio)propyl)-4-benzyloxy-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [l- (3- (amidinothio) propyl) -4-benzyloxy-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[1-(3-(Amidinothio)propyl)-5-benzyloxy-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -5-benzyloxy-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[1-(3-(Amidinothio)propyl)-6-benzyloxy-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -6-benzyloxy-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2- [ 1- (3- (Amidinothio) propyl) -7-benzylox^'-lH-indol-3-yl ] -3- (IH-indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -7-benzyloxy] -1H-indol-3-yl] -3- (IH-indol-3-yl) -maleimide;

2-[l-(3-(Amidinothio)pi apyl)-4-broni-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (3- (Amidinothio) -piphenyl) -4-bromo-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2- [ 1- (3- (Am:ldinothio) propyl) -S-brom-lH-indol-S -yl ] -3- (lH-indol· 3-yl)-maleinimid;2- [1- (3- (Am: ldinothio) propyl) -S-bromo-1H-indol-S -yl] -3- (1H-indol-3-yl) -maleimide;

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2-[1-(3-(Amidinothio)propyl)-ö-brom-lH-indor-S-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -o-bromo-lH-indor-S-yl] -3- (lH-indol-3-yl) maleimide;

2-[:i-( 3-(Amidinothio) propyl )-7-brom-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinittid;2 - [: i- (3- (amidinothio) propyl) -7-bromo-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleinide;

2-[1-(3-(Amidinothio)propyl)-4-chlor-lH-indol-3-yl]-3-(IH-. indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -4-chloro-1H-indol-3-yl] -3- (IH-indol-3-yl) -maleimide;

2-[l-(3-(Amidinothio)propyl)-5-cbicr-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [l- (3- (amidinothio) propyl) -5-cbicr-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[1-(3-(Amidinothio)propyl)-6-chlor-]H-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -6-chloro] H-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[1-(3-(Amidinothio)propyl)-7-chlor-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -7-chloro-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-tl~(3-(Amidinothio)propyl)-4-fluor-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2-tl ~ (3- (amidinothio) propyl) -4-fluoro-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[1-(3-(Amidinothio)propyl)-5-fluor-lH-indol-3-yl]-3-(IH-iiidol-3-yl) -maleinimid;2- [1- (3- (Amidinothio) propyl) -5-fluoro-1H-indol-3-yl] -3- (IH-2-idol-3-yl) -maleimide;

2-[1-(3-(Amidinothio)propyl)-6-fluor-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -6-fluoro-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[1-(3-(Amidinothio)propyl)-7-fluor-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -7-fluoro-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[1-(3-(Amidinothio)propyl)-4-hydroxy-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -4-hydroxy-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[1-(3-(Amidinothio)propyl)-5-hydroxy-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -5-hydroxy-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[1-(3-(Amidinothio)propyl)-6-hydroxy-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -6-hydroxy-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

-35--35-

2- [ 1- (3- (Amidinothio) propyl) ^-hydroxy-lH-indol^-yi ] -3·- (IH-indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -1-hydroxy-1H-indol-yl] -3 · - (IH-indol-3-yl) -maleimide;

2-[1-(3-(Amidinothio)propyl)-4-trifluormethyl-lH-indol-3-yl]-3 (lH-indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -4-trifluoromethyl-1H-indol-3-yl] -3 (1H-indol-3-yl) -maleimide;

2-[l-(3-(Amidinothio)propyl)-5-trifluormethyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3- (amidinothio) propyl) -5-trifluoromethyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2- [ 1- (3- (Amidinothio) propyl) -6-trif luorm<2thyl«lH-indol-3-yl] -3· (lH-indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -6-trifluoromethyl <1H-indol-3-yl] -3 · (1H-indol-3-yl) -maleimide;

2-[l-(3-(Amidinothio)propyl)-7-trifluormethyl-lH-indol-3-yl]-3· (lH-indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -7-trifluoromethyl-1H-indol-3-yl] -3 · (1H-indol-3-yl) -maleimide;

2-L1-(3-(Amidinothio)propyl)-4-methoxy-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2-L1 (3- (amidinothio) propyl) -4-methoxy-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2- [ 1- (3- (Amidinothio) propyl) -S-methoxy- IH- indo¹ -3-yl ] -3- (IH-indol-r-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -S-methoxy-IH-indo ¹ -3-yl] -3- (IH-indol-r-yl) -maleimide;

2- [ 1- (3-· (Amidinothio) propyl) -6-methoxy-lH-indol-3-yl ] -3- (IH-indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -6-methoxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[1-(3-(Amidinothio)propyl)-7-methoxy-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -7-methoxy-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[1-(3-(Amidinothio)propyl)-4,5-methylendioxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -4,5-methylenedioxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[1-(3-(Amidinothio)propyl)-5,6-methylendioxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -5,6-methylenedioxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[1-(3 ~(Amidinothio)propyl)-6,7-methylendioxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (3 ~ (amidinothio) propyl) -6,7-methylenedioxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[1-(3-(Amidinothio)propyl)-4-methyl-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -4-methyl-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

-36--36-

2- [ 1- (3- (Amidinothio) propyl) -5-methyl-lH-inclol-3-yl ] -3- (IH-indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -5-methyl-1H-inclol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[1-(3-(Amidinothio)propyl)-ö-methyl-lH-indol-S-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -o-methyl-lH-indol-S-yl] -3- (IH-indol-3-yl) maleimide;

2-[l-(3-(Amidinothio)propyl)-V-methyl-lH-indol-S-yl]-3-(IH-indol-3-yl)-maleinimid;2- [l- (3- (amidinothio) propyl) -V-methyl-lH-indol-S-yl] -3- (IH-indol-3-yl) maleimide;

2-[1-(3-(Amidinothio)propyl)-4-nitro-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -4-nitro-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[1-(3-(Amidinothio)propyl)-S-nitro-lH-indol-S-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -S-nitro-lH-indol-S-yl] -3- (IH-indol-3-yl) maleimide;

2-[l-(3-(Amidinothio)propyl)-ö-nitro-lH-indol-S-yl]-3-(IH-indol-3-yl)-maleinimid;2- [l- (3- (amidinothio) propyl) -o-nitro-lH-indol-S-yl] -3- (IH-indol-3-yl) maleimide;

2-[1-(3-(Amidinothio)propyl)-V-nitro-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -V-nitro-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[1-(3-(Amidinothio)propyl)-4-methylthio-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -4-methylthio-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[l-(3-(Amidinothio)propyl)-5-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3- (amidinothio) propyl) -5-methylthio-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[1-(3-(Amidinothio)propyl)-ö-methylthio-lH-indol-S-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -o-methylthio-lH-indol-S-yl] -3- (IH-indol-3-yl) maleimide;

2-[1-(3-(Amidinothio)propyl)-T-methylthio-lH-indol-S-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -T-methylthio-lH-indol-S-yl] -3- (IH-indol-3-yl) maleimide;

2-[l-(3-(Amidinothio)propyl)-4,5-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-y1)-maleinimid;2- [l- (3- (amidinothio) propyl) -4,5-dimethoxy-lH-indol-3-yl] -3- (lH-indol-3-y1) maleimide;

2-[1-(3-(Amidinothio)propyl)-5,6-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -5,6-dimethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

-37- :-37-:

2-tl-(3-(Amidinothio)propyl)-6,7-dimethoxy-iH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2-tl- (3- ( amidinothio) propyl) -6,7-dimethoxy-iH-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[4-A atylamino-l-(2-aminoethyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [4-Aylamino-1- (2-aminoethyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[5-Acetylamino-l-(2-aminoethyl)-lH-indol-3-yl]-3-(lH-indol-3-. yl)-maleinimid;2- [5-acetylamino-1- (2-aminoethyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[6-Acetylamino-l-(2-aminoethyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [6-acetylamino-l- (2-aminoethyl) -lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

2-[7-Acetylamino-l-(2-aminoethyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [7-acetylamino-l- (2-aminoethyl) -lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

2-[4-Amino-l-(2-aminoethyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [4-amino-l- (2-aminoethyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[5-Amino-l-(2-aminoethyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [5-amino-l- (2-aminoethyl) -lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

2-[6-Amino-l-(2-aminoethyl)-lH-indol-3-yl]-3-(lH-indol-3--yl)-maleinimid;2- [6-amino-l- (2-aminoethyl) -lH-indol-3-yl] -3- (lH-indol-3 - yl) maleimide;

2-[7-amino-l-(2-aminoethyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [7-amino-l- (2-aminoethyl) -lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

2-[l-(2-Aminoethyl)-4-benzyloxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (2-aminoethyl) -4-benzyloxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-t1-(2-Aminoethyl)-S-benzyloxy-lH-indol-S-yl]-3-(lH-indol-3-yl)-maleinimid;2-t1- (2-aminoethyl) -S-benzyloxy-lH-indol-S-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(2-Aminoethyl )-6-benzyloxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (2-aminoethyl) -6-benzyloxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[1-(2-Aminoethyl)-7-benzyloxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (2-Aminoethyl) -7-benzyloxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

-33- ;-33-;

2-t1-(2-Aminoethyl)-4-brom-lH-inaol-3-yl]-3-(lH-indol-3-yl) maleinimid;2-t1- (2-aminoethyl) -4-bromo-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[l-(2--Aminoethyl) -5-brom-lH-indol-3-yl]-3-(lH-indol-3-y]) maleinimid;2- [1- (2-aminoethyl) -5-bromo-1H-indol-3-yl] -3- (1H-indol-3-yl)) maleimide;

2-[l-(2-Aminoethyl)-6-brom-lH-indol-3-yl]-3-(lH-indol-3-yl) -maleinimid;2- [1- (2-aminoethyl) -6-bromo-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[l-(2-Aminoethyl)-T-brom-lH-indol-S-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (2-aminoethyl) -T-bromo-lH-indol-S-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(2-Aminoethyl) -4-chlor-lH-.lndol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (2-aminoethyl) -4-chloro-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[l-(2-Aminoethyl)-5-chlor-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (2-aminoethyl) -5-chloro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[1-(2-Aminoethyl)-ö-chlor-lH-indol-a-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (2-aminoethyl) -o-chloro-lH-indol-a-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(2-Aminoethyl)-V-chlor-lH-indol-S-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (2-aminoethyl) -V-chloro-lH-indol-S-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(2-Aminoethyl)-4-fluor-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (2-aminoethyl) -4-fluoro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[1-(2-Aminoethyl)-5-fluor-lH-indol-3-yl]-3-(lH-indol-3-yl)-0 maleinimid;2- [1- (2-aminoethyl) -5-fluoro-1H-indol-3-yl] -3- (1H-indol-3-yl) -0-maleimide;

2-[l-(2-Aminoethyl)-6-fluor-lH-indol-3~yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (2-aminoethyl) -6-fluoro-lH-indol-3 ~ yl] -3- (lH-indol-3-yl) maleimide;

2-[1-(2-Aminoethyl)-7-fluor-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (2-aminoethyl) -7-fluoro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(2-Aminoethyl)-4-hydroxy-lH-indol-3-yl]-3-(lH-indol-3-yl) maleinimid;2- [1- (2-aminoethyl) -4-hydroxy-1H-indol-3-yl] -3- (1H-indol-3-yl) maleimide;

2-(i-(2-Aminoethyl)-5-hydroxy-lH-indol-3-y'l]-3-(lH-indol-3-yl)-maleinimid;2- (i- (2-aminoethyl) -5-hydroxy-lH-indol-3-y'l] -3- (lH-indol-3-yl) maleimide;

2-[i-(2-Aminoethyl)-6-hydroxy-lH-indol-3-yl]-3-(iH-ir.^ol-3-yl)-maleinimid;2- [i- (2-aminoethyl) -6-hydroxy-lH-indol-3-yl] -3- (iH-ir ^ ol-3-yl.) Maleimide;

2-[l-(2-Aminoethyl)-7-hydroxy-lH-indol-3-yl]-3"{.lH-indol-3-yl)-. maleinimid;2- [1- (2-aminoethyl) -7-hydroxy-1H-indol-3-yl] -3 "{. LH-indol-3-yl) -maleimide;

2-[l-(2-Aminoethyl)-4-trifluci;methyl-lH-indoi-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [l- (2-aminoethyl) -4-trifluci; methyl-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[l-(2-Aminoethyl)-5-trifluormethyl-lH-indol-3-yl]-3-(lH-indol~3-yl)-maleinimid;2- [l- (2-aminoethyl) -5-trifluoromethyl-lH-indol-3-yl] -3- (lH-indol ~ 3-yl) maleimide;

2-[1-(2-Aminoethyl)-6-trifluormethyl-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (2-aminoethyl) -6-trifluoromethyl-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[1-(2-Aminoethyl)-7-trifluormethyl-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (2-aminoethyl) -7-trifluoromethyl-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[1-(2-Aminoethyl)-4-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl) maleinimid;2- [1- (2-aminoethyl) -4-methoxy-1H-indol-3-yl] -3- (1H-indol-3-yl) maleimide;

2-[l-(2-Aminoethyl)-5-iut.\:hoxy-lH-indol-3-yl]-3-(lH-indol-3-yl) raalemimid;2- [1- (2-aminoethyl) -5-iuto: hoxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -aalemimide;

2-[l-(2-Aminoethyl)-ö-methoxy-lH-indol-S-yl]-3-(lH-indol-3-yl) maleinimid;2- [1- (2-aminoethyl) -ö-methoxy-1H-indol-S-yl] -3- (1H-indol-3-yl) -maleimide;

2-[l-(2-Aminoetiiyl)-7-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl) roaleinimid;2- [1- (2-aminoethyl) -7-methoxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -roalimide;

2-[l-(2-An>.inoethyl)-4,5-methylendioxy-lH-indol-3-yl]-3-(lH- -icaleinimid?2- [1- (2-An> .inoethyl) -4,5-methylenedioxy-1H-indol-3-yl] -3- (1H-cicalimide?

2-fl-(2-Aminoethyl)-5,e-methylendioxy-lH-indol-S-yl]-3-(IH-indol-3-yl)-maleinimid;2-fl- (2-aminoethyl) -5, e-methylenedioxy-lH-indol-S-yl] -3- (IH-indol-3-yl) maleimide;

-⁴⁰~- ⁴⁰ ~

2-[1-(2-Aminoethyl)-6,T-methylendioxy-lH-indol-B-yl]-3-(IH-indol-3-yI)-maleinimid;2- [1- (2-aminoethyl) -6, T-methylenedioxy-lH-indole-B-yl] -3- (IH-indol-3-yl) maleimide;

2-[l-(2-Aminoethyl)-4~methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (2-aminoethyl) -4 ~ methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(2-Aminoethyl)-5-methyl-lH-indol-3-yl]-3-(lH-indol-3-yi)-maleinimid;2- [l- (2-aminoethyl) -5-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(2-Aminoethyl)-6-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (2-aminoethyl) -6-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[1-(2-Aminoethyl)-7-inethyl-lH-indol-3-yl]-3-(lH-indol-3~yl)-maleinimid;2- [1- (2-aminoethyl) -7-inethyl-lH-indol-3-yl] -3- (lH-indol-3 ~ yl) maleimide;

2-[1-(2-Aminoethyl)-4-nitro-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (2-aminoethyl) -4-nitro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(2-Aminoethyl)-5-nitro-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (2-aminoethyl) -5-nitro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[1-(2-Aminoethyl)-6-nitro-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (2-aminoethyl) -6-nitro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2- [1- (2-Aminoethyl) -7-nitro-lH-indol-3-yl] -3- (lH-indol-3-yl¹.-maleinimid;2- [1- (2-aminoethyl) -7-nitro-1H-indol-3-yl] -3- (1H-indol-3-yl ^{) 1} -maleinimide;

2-[l-(2-Aminoethyl)-4-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (2-aminoethyl) -4-methylthio-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[1-(2-Aminoethyl)-5-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (2-aminoethyl) -5-methylthio-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(2-Aminoethyl)-e-methylthio-lH-indol-S-yl]-3-(lH-indol-3· yl)-maleinimid;2- [1- (2-aminoethyl) -e-methylthio-1H-indol-S-yl] -3- (1H-indol-3-yl) -maleimide;

2-[l-( 2-Aminoethyl )-7-methylthio-lH-indol--3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (2-aminoethyl) -7-methylthio-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[i-(2-Aminoethyl)-4,5-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleiniicid;2- [i- (2-aminoethyl) -4,5-dimethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) -maleiniicid;

2-[1-(2-Aminoethyl)-5,6-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (2-aminoethyl) -5,6-dimethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[1-(2-Aminoethyl)-6,7-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (2-aminoethyl) -6,7-dimethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[4-Acetylamino-l-(3-aminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [4-acetylamino-l- (3-aminopropyl) -lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

2-[5-Acetylaraino-l-(3-aminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [5-Acetylaraino-l- (3-aminopropyl) -lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

2-[6-Acetylamino-l-(3-aminopropyl)-lH-indol-3-yl]-3-(iH-indol-3-yl)-maleinimid;2- [6-acetylamino-l- (3-aminopropyl) -lH-indol-3-yl] -3- (iH-indol-3-yl) maleimide;

2-[7-Acetylamino-l-(3-aminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [7-acetylamino-l- (3-aminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[4-Amino-l-(3-aminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-raaleinimid;2- [4-amino-l- (3-aminopropyl) -lH-indol-3-yl] -raaleinimid -3- (lH-indol-3-yl);

2-[5-Amino-l-(3-aminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [5-Amino-l- (3-aminopropyl) -lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

2-[6-Amino-l-(3-aminopropyl)-lH-indoi-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [6-amino-l- (3-aminopropyl) -lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

2-[7-Amino-l-(3-aminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-raaleinimid;2- [7-amino-l- (3-aminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) -raaleinimid;

2-[1-(3-Aminopropyl)-A-benzyloxy-lH-indol-S-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (3-aminopropyl) -A-benzyloxy-lH-indol-S-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-Aminopropyl)-5-benzyloxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-aminopropyl) -5-benzyloxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

299970 -⁴"- 299970 -⁴"-

2-[1-(3-Aminopropyl)-e-benzyloxy-lH-indol-O-yl]-3-(lK-indol-3-yl)-maleinimid;2- [1- (3-aminopropyl) -e-benzyloxy-lH-indol-O-yl] -3- (lK-indol-3-yl) maleimide;

2-[l-( 3-Aminopropyl )-7-benzyloxy-lH-ir.dol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (3-aminopropyl) -7-benzyloxy-lH-ir.dol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[l-(3-Aminopropyl)-4-brom-lH-indol-3-yl]-3-(lH-indol-3-yl)-.maleinimid;2- [l- (3-aminopropyl) -4-bromo-lH-indol-3-yl] -3- (lH-indol-3-yl) - maleimide.

2-[l-(3-Aminopropyl)-5-brom-lH-indol-3-yl]-3-(iH-indol-3-yl)-maleinimid;2- [l- (3-aminopropyl) -5-bromo-lH-indol-3-yl] -3- (iH-indol-3-yl) maleimide;

2-[l-(3-Aminopropyl)-6-brom-lH-i .dol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (3-aminopropyl) -6-bromo-1H-i -dol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[1-(3-Aminopropyl)-T-brom-lH-indol-S-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (3-aminopropyl) -T-bromo-lH-indol-S-yl] -3- (lH-indol-3-yl) maleimide;

2-[1-(3-Aminopropyl)-4-chlor-lH-indol-3-yl]-3-(lH-indol-3-yl) maleinimid;2- [1- (3-aminopropyl) -4-chloro-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[l-(3-Aminopropyl)-5-chlor-lH-indol-3-yl]-3-(lH-indol-3-yl)· maleinimid;2- [1- (3-aminopropyl) -5-chloro-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[1-(3-Aminopropyl)-6-chlor-lH-indol-3-yl]-3-(lH-indol-3-yl) · maleinimid;2- [1- (3-aminopropyl) -6-chloro-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[l-(3-Aminopropyl)-7-chlor-lH-indol-3-yl]-3-(lH-indol-3-yl)· maleinimid;2- [1- (3-aminopropyl) -7-chloro-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[l-( 3-Aminopropyl )-4-fluor-lH-indol-3-yl]-3-(:.H-indol-3-yl) maleinimid;2- [1- (3-aminopropyl) -4-fluoro-1H-indol-3-yl] -3- (: H-indol-3-yl) maleimide;

2-[l-(3-Aminopropyl)-5-fluor-lH-indol-3-yl]-3-(lH-indol-3-yl) maleinimid;2- [1- (3-aminopropyl) -5-fluoro-1H-indol-3-yl] -3- (1H-indol-3-yl) maleimide;

2-[l-(3-Aminopropyl)-6-fluor-lH-indol-3-yl]-3-(lH-indol-3-yl) maleinimid;2- [1- (3-aminopropyl) -6-fluoro-1H-indol-3-yl] -3- (1H-indol-3-yl) maleimide;

-42--42-

2-[l-(3-Aminopropyl)-7-fluor-lH-indol-3-yl]-3-(lH-indol-3-yl) maleinimid;2- [1- (3-aminopropyl) -7-fluoro-1H-indol-3-yl] -3- (1H-indol-3-yl) maleimide;

2-[l-(3-Aminopropyl)-4-hydroxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-aminopropyl) -4-hydroxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[1-(3-Aminopropyl)-S-hydroxy-lH-indol-S-yl]-3-(lH-indcl-3-yl)-maleinimid;2- [1- (3-aminopropyl) -S-hydroxy-lH-indol-S-yl] -3- (lH-indcl-3-yl) maleimide;

2-[l-(3-Aminopropyl) -6-hy.roxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (3-aminopropyl) -6-hydroxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[l- (3-^.minopropyl) -7-hydroxy-lH-indol-3-yl]-3-(lH-indol-3-yl) -ma.l 11uimid;2- [l- (. 3 - ^ minopropyl) -7-hydroxy-lH-indol-3-yl] -3- (lH-indol-3-yl) -ma.l 1 1uimid;

2-r:i - (3-Aminopropyl) -4-trifluorTT-thyl-lH-indol-3-yl] -3- (IH-indol-3-yl)-maleinimid;2-r: i - (3-aminopropyl) -4-trifluoro-TT-methyl-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[1-(3-Aminopropyl)-5-trifluonnethyl-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (3-aminopropyl) -5-trifluonnethyl-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[1-(3-Aminopropyl)-ό-trifluormethyl-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (3-aminopropyl) -ό-trifluoromethyl-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[l-(3-Aminopropyl)-7-trifluormethyl-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [l- (3-aminopropyl) -7-trifluoromethyl-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[l-(3-Aminopropyl)-4-methoxy-iH-indol-3-yl]-3-(lH-indol-3-0 yl)-maleinimid;2- [1- (3-aminopropyl) -4-methoxy-iH-indol-3-yl] -3- (1H-indol-3-o-yl) -maleimide;

2-[I-(3-Aminopropyl)-S-methoxy-lH-indol-S-ylJ-S-ilH-indol-S-yl)-maleinimid;2- [I- (3-aminopropyl) -S-methoxy-lH-indol-S-S-YLJ-ILH-indol-S-yl) maleimide;

2-[l-(3-Aminopropyi)-6-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-Aminopropyi) -6-methoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-Aminopropyl)-7-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-aminopropyl) -7-methoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[1-(3-Aminopropyl)-4,5-methylendioxy-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (3-aminopropyl) -4,5-methylenedioxy-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[1-(3-Aminopropyl)-5,6-methylendioxy-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (3-aminopropyl) -5,6-methylenedioxy-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[l-(3-Aminopropyl)-6,7-methylendioxy-lH-indol-3-yl]-3-(lH-. indol-3-yl)-maleinimid;2- [1- (3-aminopropyl) -6,7-methylenedioxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[l-(3-Aminopropyl)-4-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl) maleinimid;2- [1- (3-aminopropyl) -4-methyl-1H-indol-3-yl] -3- (1H-indol-3-yl) maleimide;

2-[l-(3-Aminopropyl)-5-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl) maleinimid;2- [1- (3-aminopropyl) -5-methyl-1H-indol-3-yl] -3- (1H-indol-3-yl) maleimide;

2-[1-(3-Aminopropyl)-6-methyl-¹H-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (3-aminopropyl) ^-6-methyl-1 H-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-Aminopropyl)-7-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-aminopropyl) -7-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-Aminopropyl)-4-nitro-lH-.indol-3-yl]-3-(lH-indol-3-yl)-raaleinimid;2- [l- (3-aminopropyl) -4-nitro-lH-.indol-3-yl] -3- (lH-indol-3-yl) -raaleinimid;

2-[l-(3-Aminopropyl)-5-nitro-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-aminopropyl) -5-nitro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-Aminopropyl)-6-nitro~lH-indol-3-yl]-3-(lH-indoi-3-yl)-0 maleinimid;2- [1- (3-aminopropyl) -6-nitro-1H-indol-3-yl] -3- (1H-indo-3-yl) -0-maleimide;

2-[l-(3-Aminoprüpyl)-7-n-.tro-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-Aminoprüpyl) -7-n-.tro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-Aminopropyl)-4-methylthio-lH-indol-3-yl]-3-(lH-i.ndol-3-yl)-maleinimid;2- [l- (3-aminopropyl) -4-methylthio-lH-indol-3-yl] -3- (lH-i.ndol-3-yl) maleimide;

2-[l-(3-Aminopropyl)-5-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-aminopropyl) -5-methylthio-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

-45--45-

2-[1-(3-Aminopropyl)-ö-methylthio-lH-indol-S-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (3-Aminopropyl) -o-methylthio-lH-indol-S-yl] -3- (lH-indol-3-yl) maleimide;

2-(l"(3-Amir.opropyl)-7-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- (l "(3-Amir.opropyl) -7-methylthio-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2- [1-(3-Aminopropyl)-4,5-dimethoxy-lH-indol-3-yl]-3-(lH-indol-" 3-yl)-maleinimid;2- [1- (3-aminopropyl) -4,5-dimethoxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[1-(3-Aminopropyl)-5,6-dimethoxy-lH-indol~3-yl]~3-(lH-indol-3-yλ)-maleinimid;2- [1- (3-aminopropyl) -5,6-dimethoxy-lH-indol ~ 3-yl] ~ 3- (lH-indol-3-yλ) maleimide;

2-[1-(3-Aminopropyl)-6,7-dimethoxy-lH-indol-3-yl1-3-(lH-indol-3-yl)-maleinimid;2- 1- (3-aminopropyl) maleimide -6,7-dimethoxy-lH-indol-3-yl1-3- (lH-indol-3-yl) [;

(±)-2-[4-Acetylamino-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [4-acetylamino-l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[5-Acetylamino-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [5-acetylamino-l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[6-Acetylamino-l-(3-ethoxy-2-hydroxypropyl)-lK-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [6-acetylamino-l- (3-ethoxy-2-hydroxypropyl) -LK-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[7-Acetylamino-l-(3-ethoxy-2-hydro\ypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [7-acetylamino-l- (3-ethoxy-2-hydro \ ypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[4-Amino-l-(3~ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3 (lH-indol-3-yl)-maleinimid;(±) -2- [4-amino-1- (3-ethoxy-2-hydroxypropyl) -1H-indol-3-yl] -3 (1H-indol-3-yl) -maleimide;

(±)-2-[5-Amino-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3 (lH-indol-3-yl)-maleinimid;(±) -2- [5-amino-1- (3-ethoxy-2-hydroxypropyl) -1H-indol-3-yl] -3 (1H-indol-3-yl) -maleimide;

(±)-2-[6-Amino-l-(3-ethoxy-2-hydrcxypropyl)-lH-indol-3-yl]-3 (lH-indol-3-yl)-maleinimid;(±) -2- [6-amino-1- (3-ethoxy-2-hydroxypropyl) -1H-indol-3-yl] -3 (1H-indol-3-yl) -maleimide;

(±)-2-[7-Amino-i-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3 (lH-indol-3-yl)-maleinimid;(±) -2- [7-amino-i- (3-ethoxy-2-hydroxypropyl) -1H-indol-3-yl] -3 (1H-indol-3-yl) -maleimide;

-46--46-

(±)-2-[4-Benzyloxy-l-(3-ethoxy~2-hydroxypropyl)-lH-indol-3-yl]· 3-(lH-indol-3-yl)-maleinimid;(±) -2- [4-Benzyloxy-1- (3-ethoxy-2-hydroxypropyl) -1H-indol-3-yl] .3- (1H-indol-3-yl) -maleimide;

(±)-2-[5-Benzyloxy-l-(3-ethoxy-2-hydroxypropy1)-lH-indol-3-yl] 3-(lH-indol-3-yl)-maleinimid;(±) -2- [5-Benzyloxy-1- (3-ethoxy-2-hydroxypropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±)-2-[6-Benzyloxy-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]· - 3-(lH-indol-3-yl)-maleinimid;(±) -2- [6-Benzyloxy-1- (3-ethoxy-2-hydroxypropyl) -1H-indol-3-yl].-3- (1H-indol-3-yl) -maleimide;

(±)-2-[7-Benzyloxy-l-(3-ethoxy-2-hydroxypropy1) -lH-indol-3-yl] 3-(lH-indol-3-yl)-maleinimid;(±) -2- [7-Benzyloxy-1- (3-ethoxy-2-hydroxypropyl) -1H-indol-3-yl] 3- (1H-indol-3-yl) -maleimide;

(±)-2-[4-Brom-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [4-bromo-l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[5-Brom-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [5-bromo-l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[6-Brom-l-(3-ethoxy-2-hydroxyprop;₁.¹ -LH-indol-3-yl ]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [6-bromo-1- (3-ethoxy-2-hydroxyprop; ₁ : ¹ -LH-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(i)-2-[7-Brom-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(I) -2- [7-bromo-l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[4-Chlor-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [4-chloro-l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[5-Chlor-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-malei»->imid;(±) -2- [5-chloro-l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) -malei »-> imide;

(±)-2-[6-Chlor-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yi) -maieiniinid;(±) -2- [6-chloro-1- (3-ethoxy-2-hydroxypropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maieniniinide;

(±)-2-[7-Chlor-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [7-chloro-l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(3-Ethoxy-2-hydroxypropyl)-4-fluor-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-ethoxy-2-hydroxypropyl) -4-fluoro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

-47--47-

(±) -2-(l-(3-Ethoxy-2-hydroxypropyl)-5-fluor-lH-indol-:- (lH-indol-3-yl)-maleinimid;(±) -2- (1- (3-ethoxy-2-hydroxypropyl) -5-fluoro-1H-indole -: - (1H-indol-3-yl) -maleimide;

(±)-2-[l-(3-Ethoxy-2-hydroxypropyl)-6-fluor-lH-indol-3-yI]-3 (lH-indol-3-yl)-maleinimid;(±) -2- [1- (3-ethoxy-2-hydroxypropyl) -6-fluoro-1H-indol-3-yl] -3 (1H-indol-3-yl) -maleimide;

(±) -2-[l-(3-Ethoxy-2-hydroxypropyl) -7~fluor-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [1- (3-ethoxy-2-hydroxypropyl) -7-fluoro-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±)-2-[1-(3-Ethoxy-2-hydroxypropy1)-4-hydroxy-iK-indol-3-y1]-3 (lH-indol-3-yl)-maleinimid;(±) -2- [1- (3-ethoxy-2-hydroxypropyl) -4-hydroxy-1K-indol-3-yl] -3 (1H-indol-3-yl) -maleimide;

(±)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5-hydroxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-ethoxy-2-hydroxypropyl) -5-hydroxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(3-Ethoxy-2-hydroxypropyl)-6-hydroxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-ethoxy-2-hydroxypropyl) -6-hydroxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(3-Ethoxy-2-hydroxypropyl)-7-hydroxy-lH-indol-3-yl]-3-(lH-indol-3=yl)-maleinimid;(±) -2- [l- (3-ethoxy-2-hydroxypropyl) -7-hydroxy-lH-indol-3-yl] -3- (lH-indol-3 = yl) maleimide;

(±)-2-[l-(3-Ethoxy-2-hydroxypropyl)-4-trifluormethyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-ethoxy-2-hydroxypropyl) -4-trifluoromethyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5-trifluormethyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-ethoxy-2-hydroxypropyl) -5-trifluoromethyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(3-Ethoxy-2-hydroxypropyl)-6-trifluormethyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-ethoxy-2-hydroxypropyl) -6-trifluoromethyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(3-Ethoxy-2-hydroxypropyl)-7-trifluormethyl-lH-indol-3-yl)-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-ethoxy-2-hydroxypropyl) -7-trifluoromethyl-lH-indol-3-yl) -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(3-Ethoxy-2-hydroxypropyl)-4-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-ethoxy-2-hydroxypropyl) -4-methoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[1-(3-Ethoxy-2-hydroxypropy1)-5-methoxy-lH-indol-3-yl]-3 · (lH-indol-3-yl)-maleinimid;(±) -2- [1- (3-ethoxy-2-hydroxypropyl) -5-methoxy-1H-indol-3-yl] -3 · (1H-indol-3-yl) -maleimide;

(±)-2-[l-(3-Ethoxy-2-hydroxypropyi)-6-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-ethoxy-2-hydroxypropyl) -6-methoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(3-Ethoxy-2-hydroxypropyl)-7-methoxy-lH-indol--3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-ethoxy-2-hydroxypropyl) -7-methoxy-lH-indol - 3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(3-Ethoxy-2-hydroxypropyl)-4,5-methylendioxy-lH-indol-'3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-ethoxy-2-hydroxypropyl) -4,5-methylenedioxy-lH-indol-'3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(3~Ethoxy-2-hydroxypropyl)-5,6-methylendioxy-lH-indol-3-/l]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (3 ~ ethoxy-2-hydroxypropyl) -5,6-methylenedioxy-lH-indole-3- / l] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(3-Ethoxy-2-hydroxypropyl)-6,7-methylendioxy-lH-indol· 3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [1- (3-ethoxy-2-hydroxypropyl) -6,7-methylenedioxy-1H-indole-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±)-2-[l-(3-Ethoxy-2-hydroxypropyl)-4-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-ethoxy-2-hydroxypropyl) -4-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-ethoxy-2-hydroxypropyl) -5-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(3-Ethoxy-2-hydroxypropyl)-6-methyl-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(±) -2- [l- (3-ethoxy-2-hydroxypropyl) -6-methyl-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

(±)-2-[l-(3-Ethoxy-2-hydroxypropyl)-7-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-ethoxy-2-hydroxypropyl) -7-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(3-Ethoxy-2-hydroxypropyl)-4-nitro-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-ethoxy-2-hydroxypropyl) -4-nitro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5-nitro-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-ethoxy-2-hydroxypropyl) -5-nitro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[1-(3-Ethoxy-2-hydroxypropyl)-6-nitro-lH-indol-3-yl]-3-(lH-indol-3-yi)-maleinimid;(±) -2- [1- (3-ethoxy-2-hydroxypropyl) -6-nitro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(3-Ethoxy-2-hydroxypropyl)-7-nitro-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-ethoxy-2-hydroxypropyl) -7-nitro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

-49--49-

(±) -2-[l-(3-Ethoxy-2-hydroxypropyl)^-m yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [1- (3-ethoxy-2-hydroxypropyl) -m-yl] -3- (1H-indol-3-yl) -maleimide;

(±)-2-[l-(3-Ethoxy-2-hydroxypropyl)-S-methylthio-lH-indol-S-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-ethoxy-2-hydroxypropyl) -S-methylthio-lH-indol-S-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(3-Ethoxy-2-hydroxypropyl)-6-methy.lthio-lH-indol-3- - yl]-3-(lH-indol-3-yl) --maleinimid;(±) -2- [1- (3-ethoxy-2-hydroxypropyl) -6-methylthio-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±)-2-[l-(3-Ethoxy=2-hydroxypropyl)-7-methylthio-lH-indol-3-yl ]-3-(lH-indol-3-y.\)-maleinimid;(±) -2- [1- (3-ethoxy-2-hydroxypropyl) -7-methylthio-1H-indol-3-yl] -3- (1H-indol-3-yl) maleimide;

(±)-2-[l-(3-Ethoxy-2-hydroxypropyl)-4,5-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-ethoxy-2-hydroxypropyl) -4,5-dimethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[1-(3-Ethoxy-2-hydroxypropy1)-5,6-dimethoxy-lH-indol-3 yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [1- (3-ethoxy-2-hydroxypropyl) -5,6-dimethoxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±)-2-[l-(3-Ethoxy-2-hydroxypropyl)-6,7-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-ethoxy-2-hydroxypropyl) -6,7-dimethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[4-Acetylamino-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleiniraid;(+) - 2- [4-acetylamino-l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) -maleiniraid;

(+)-2-[5-Acetylamino-l-(3~ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [5-Acetylamino-l- (3 ~ ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[6-Acetylamino-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [6-acetylamino-l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[7-Acetylamino-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [7-acetylamino-l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

-2-[4-Amino-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;-2- [4-amino-l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

(+)-2-[5-Amino-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yX)-maleinimid;(+) - 2- [5-Amino-l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yX) maleimide;

-50- ; ;-50-; ;

-2-[6-Amino-l-(3-ethoxy-2-hydroxypropyl)-lH-iridol-3-yl]-3· (lH-indol-3-yl)-maleinimid;-2- [6-Amino-1- (3-ethoxy-2-hydroxypropyl) -1H-iridol-3-yl] -3 · (1H-indol-3-yl) -maleimide;

2-[7-Amino-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [7-amino-l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

(+)-2-[4-Benzylo>y-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]· 3-(lH-indol-3-yl)-maleinimid;(+) - 2- [4-Benzylo] y- 1- (3-ethoxy-2-hydroxypropyl) -1H-indol-3-yl] .3- (1H-indol-3-yl) -maleimide;

-2-[5-Benzyloxy-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;-2- [5-benzyloxy-l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[6-Benzyloxy-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-y]] 3-(lH-indol-3-yl)-maleinimid;(+) - 2- [6-Benzyloxy-1- (3-ethoxy-2-hydroxypropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[7-Benzyloxy-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl] 3-(lH-indol-3-yl)-maleinimid;(+) - 2- [7-Benzyloxy-1- (3-ethoxy-2-hydroxypropyl) -1H-indol-3-yl] 3- (1H-indol-3-yl) -maleimide;

(+)-2-[4-Brom-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [4-bromo-l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[5-Brom-l-(3-ethoxy-2-hydroxypropyl)-lH-indol--3-yl]-3 (lH-indol-3-yl)-maleinimid;(+) - 2- [5-bromo-1- (3-ethoxy-2-hydroxypropyl) -1H-indol-3-yl] -3 (1H-indol-3-yl) -maleimide;

(+)-2-[6-Brom-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3 (lH-indol-3-yl)-maleinimid;(+) - 2- [6-bromo-1- (3-ethoxy-2-hydroxypropyl) -1H-indol-3-yl] -3 (1H-indol-3-yl) -maleimide;

-2-[7-Brom-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;-2- [7-bromo-l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[4-Chlor-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3 (lH-indol-3-yl)-maleinimid;(+) - 2- [4-chloro-1- (3-ethoxy-2-hydroxypropyl) -1H-indol-3-yl] -3 (1H-indol-3-yl) -maleimide;

-2-[5-Chlor-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3 (lH-indol-3-yl)-maleinimid;-2- [5-chloro-1- (3-ethoxy-2-hydroxypropyl) -1H-indol-3-yl] -3 (1H-indol-3-yl) -maleimide;

(+)-2-[6-Chlor-l-(3-ethoxy-2-hydruxypropyl)-lH-indol-3-yl]-3 (lH-indol-3-yl)-maleinimid;(+) - 2- [6-chloro-1- (3-ethoxy-2-hydroxypropyl) -1H-indol-3-yl] -3 (1H-indol-3-yl) -maleimide;

-51--51-

( + )-2-[7-Chlor-l-(3-ethoxy-2-hydro\Typropyl)-lH-ir.doi-3-yl]-3-(lH-indol-3-yl)-malei."imid;(+) -2- [7-Chloro-1- (3-ethoxy-2-hydroxyppropyl) -lH-ir.doi-3-yl] -3- (1H-indol-3-yl) -malei. "imide;

(+)-2-[l-(3-Ethoxy-2-hydroxypropyl)-4-fluor-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-ethoxy-2-hydroxypropyl) -4-fluoro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5-fluor-lH-indol-3-yl]-3-•(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-ethoxy-2-hydroxypropyl) -5-fluoro-lH-indol-3-yl] -3- • (lH-indol-3-yl) maleimide;

( + )-2~[l-(3-Ethoxy-2-hydroxypropy;., ~6- fiuor-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2 - [1- (3-Ethoxy-2-hydroxypropyl;., ~ 6 -fluoro-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[1-(3 -Ethoxy-2-hydroxypropyl)-7-fluor-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [1- (3-ethoxy-2-hydroxypropyl) -7-fluoro-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[l-(3-Ethoxy-2-hydroxypropyl)-4-hydroxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-ethoxy-2-hydroxypropyl) -4-hydroxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5-hydroxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-ethoxy-2-hydroxypropyl) -5-hydroxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(3-Ethoxy=2=hydroxypropyi;-6-hydroxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-Ethoxy = 2 = hydroxypropyl; -6-hydroxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

-2-[l-(3-Ethoxy-2-hydroxypropyl) -7-hydroxy-3.H-indol-3-yl]-3· (lH-indol-3-yl)-maleinimid;-2- [1- (3-ethoxy-2-hydroxypropyl) -7-hydroxy-3 H -indol-3-yl] -3 · (1H-indol-3-yl) -maleimide;

(+)-2-[l-(3-Ethoxy-2-hydroxypropyl)-4-trifluormethyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-ethoxy-2-hydroxypropyl) -4-trifluoromethyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5-trifluormethyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-ethoxy-2-hydroxypropyl) -5-trifluoromethyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(3-Ethoxy-2-hydrüxypropyl)-6-trifluormethyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;( +) -2- [1- (3-ethoxy-2-hydroxypropyl) -6-trifluoromethyl-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[1-(3-Ethoxy-2-hydroxypropyl)-7-trifluormethyl-lH-indol-3-yl]-3-(lH-indol-3-y1)-maleinimid;(+) - 2- [1- (3-ethoxy-2-hydroxypropyl) -7-trifluoromethyl-lH-indol-3-yl] -3- (lH-indol-3-y1) maleimide;

( + ) -2-[l-(3-Ethoxy-2-hydroxypropyl) ~4-me\:noxy-iH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) -2- [1- (3-ethoxy-2-hydroxypropyl) -4-methoxy-iH-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-ethoxy-2-hydroxypropyl) -5-methoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+) -2-[1- (3-Ethoxy-2-hydroxypropyl) -6-iQ«thoxy-iH-indol-3-yl ] -3-(lH-indol-3-yl)-maleinimid;(+) -2- [1- (3-ethoxy-2-hydroxypropyl) -6-i-quethoxy-iH-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[l-(3-Ethoxy-2-hydroxypropyl)-7-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-icualeinimid;(+) - 2- [l- (3-ethoxy-2-hydroxypropyl) -7-methoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) -icualeinimid;

(+)-2-[1-(3-Ethoxy-2-hydroxypropyl)-4, ^K -methylendioxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [1- (3-Ethoxy-2-hydroxypropyl) -4, ^K -methylenedioxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+) ~2--[l-(3-Ethoxy-2-hydroxypropyl) -5, 6-inothylendioxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2 - [1- (3-Ethoxy-2-hydroxypropyl) -5,6-inothylene dioxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[l-(3-Ethoxy-2-hydroxypropy' -e/Z-methylendioxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-mdleinimid;(+) - 2- [1- (3-Ethoxy-2-hydroxypropyl-e / Z-methylenedioxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[l-(3-Ethoxy-2-hydroxypropyl)-4-mathyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-ethoxy-2-hydroxypropyl) -4-mathyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleiniuid;(+) - 2- [l- (3-ethoxy-2-hydroxypropyl) -5-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) -maleiniuid;

(+)-2-[l-(3-Ethoxy-2-hydroxypropyl)-6-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-ethoxy-2-hydroxypropyl) -6-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+) -2- [i-( 3 -Ethoxy-2 -hydroxypropyl) -7 -methyl-lH-indol-3-yl] -3·- (lH-indol-3-yl)-maleinimid;(+) -2- [i- (3-ethoxy-2-hydroxypropyl) -7-methyl-1H-indol-3-yl] -3 · - (1H-indol-3-yl) -maleimide;

(+)-2-[l-(3-Ethoxy-2-hydro>.ypropyl)-4-nitro-lH-indol-3-yl]-3-(lH-indol-3-y1)-maleinimid;(+) - 2- [l- (3-ethoxy-2-hydro> .ypropyl) -4-nitro-lH-indol-3-yl] -3- (lH-indol-3-y1) maleimide;

(+)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5-nitro-lH-indol-3-yl]-3-(lH-indol-3-y1)-maleinimid;(+) - 2- [l- (3-ethoxy-2-hydroxypropyl) -5-nitro-lH-indol-3-yl] -3- (lH-indol-3-y1) maleimide;

-53- ;-53-;

(+)-2-[l-(3-Ethoxy-2-hydroxypropyl)-6-nitro-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-ethoxy-2-hydroxypropyl) -6-nitro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(3-Ethoxy-2-hydroxypropyl)-7-nitro-lH-indol-3-yl]-3-(lH-indol-3-yi)-maleinimid;(+) - 2- [l- (3-ethoxy-2-hydroxypropyl) -7-nitro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

( + )-2-[l-(3-Ethoxy-2-hydroxypropyl) -A-metnylthio-lH-indol^- yl]-3-(lH-indol-3-yl)-maleinimid;(+) -2- [1- (3-ethoxy-2-hydroxypropyl) -A-methylthio-1H-indol-1-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[l-(3-Ethoxy-2-bydroxypropyl)-5-methylthio-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-ethoxy-2-bydroxypropyl) -5-methylthio-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

(+)-2-[l-(3-Ethoxy-2-hydroxypropyl)-6-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-ethoxy-2-hydroxypropyl) -6-methylthio-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(3-Ethoxy-2-hydroxypropyl)-7-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-ethoxy-2-hydroxypropyl) -7-methylthio-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(3-Ethoxy-2-hydroxypropyl)-4,5-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-ethoxy-2-hydroxypropyl) -4,5-dimethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5_;6-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [1- (3-ethoxy-2-hydroxypropyl) -5 _; 6-dimethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(3-Ethoxy-2-hyurcxypropyl)-6,7-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yi)-maleinimid;(+) - 2- [l- (3-ethoxy-2-hyurcxypropyl) -6,7-dimethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[4-Acetylamino-.-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [4-acetylamino -.- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[5-Acetylamino-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [5-Acetylamino-l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

{-) -2-[o-Acetylamino-l-(3-ethoxy-2-hy^.roxypropyl) -lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;{-) -2- [o-acetylamino-1- (3-ethoxy-2-hydroxypropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(-)-2-[7-Acetylamino-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3"(lH-indol-3-yl)-maleinimid;(-) - 2- [7-acetylamino-l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -3 '(lH-indol-3-yl) maleimide;

2919?O -54- 2919? O -54-

(-)-2-[4-Amino-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [4-amino-l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-) -2-[5-Amino-l-(3-ethoxy-2-hydroxypropy 1) -lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) -2- [5-Amino-1- (3-ethoxy-2-hydroxypropyl-1) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(-)-2-[6-Amino-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [6-amino-l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[7-Amino-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [7-amino-l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[4-Benzyloxy-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]· 3-(lH-indol-3-yl)-maleinimid;(-) - 2- [4-Benzyloxy-1- (3-ethoxy-2-hydroxypropyl) -1H-indol-3-yl] .3- (1H-indol-3-yl) -maleimide;

(-)-2-[5-Benzyloxy-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]· 3-(lH-indol-3-yl)-maleinimid;(-) - 2- [5-Benzyloxy-1- (3-ethoxy-2-hydroxypropyl) -1H-indol-3-yl] .3- (1H-indol-3-yl) -maleimide;

(-)-2-[6-Benzyloxy-l-(3-ethoxy-2-hydroxyprcpyl)-lH-indol-3-yl] 3-(lH-indol-3-yl)-maleinimid;(-) - 2- [6-Benzyloxy-1- (3-ethoxy-2-hydroxypropyl) -1H-indol-3-yl] 3- (1H-indol-3-yl) -maleimide;

(••)-2-[7-Bsnzyloxy-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl] 3-(lH-indol-3-yl)-maleinimid;(••) -2- [7-Bsnzyloxy-1- (3-ethoxy-2-hydroxypropyl) -1H-indol-3-yl] 3- (1H-indol-3-yl) -maleimide;

(-)-2-[4-Brca-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [4-Brca-l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[5-Brom-l-(3-ethoxy-2-hydroxypropy1)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [5-bromo-l- (3-ethoxy-2-hydroxypropy1) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[6-Brom-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [6-bromo-l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[7-Brom-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-y1)-aaleinimid;(-) - 2- [7-bromo-l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-y1) -aaleinimid;

(-)-2-[4-Chlor-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3 (lH-indcl-3-yl)-maleinimid;(-) - 2- [4-chloro-1- (3-ethoxy-2-hydroxypropyl) -1H-indol-3-yl] -3 (1H-indcl-3-yl) -maleimide;

-55--55-

(-)-2-[5-Chlor-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [5-chloro-l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[6-Chlor-l-(3-ethoxy-2-hydroxypropyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [6-chloro-l- (3-ethoxy-2-hydroxypropyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[7-Chlor-l-(3-ethoxy-2-hydr rxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-naleinimid;(-) - 2- [7-chloro-1- (3-ethoxy-2-hydroxypropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -naleinimide;

(-)-2-[l-(3-Ethoxy-2-hydroxypropyl)-4-fluor-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(3-ethoxy-2-hydroxypropyl) -4-fluoro-l- lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

(-)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5-fluor-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(3-ethoxy-2-hydroxypropyl) -5-fluoro-l-lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

(-)-2-[l-(3-Ethoxy-2-hydroxypropyl)-6-fluor-.iH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(3-ethoxy-2-hydroxypropyl) -6-fluoro-l- .iH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

(-)-2-[l-(3-Ethoxy-2-hydroxypropyl)-7-fluor-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(3-ethoxy-2-hydroxypropyl) -7-fluoro-l-lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

(-)-2-[l-(3-Ethoxy-2-hydroxypropyl)-4-hydroxy-lH-indol-3-yl]-3 (lH-indol-3-yl)-maleinimid;(-) - 2- [1- (3-Ethoxy-2-hydroxypropyl) -4-hydroxy-1H-indol-3-yl] -3 (1H-indol-3-yl) -maleimide;

(-)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5-hydroxy-lH-indol-3~yl]-3 (lH-indol-3-yl)-maleinimid;(-) - 2- [1- (3-Ethoxy-2-hydroxypropyl) -5-hydroxy-1H-indol-3-yl] -3 (1H-indol-3-yl) -maleimide;

(lH-indol-3-_ri)-maleinimid; _{(lH-indol-3-r} i) maleimide;

(-)-2-[1-(3-Ethoxy-2-hydroxypropy1)-T-hydrcxy-lH-indol-S-yl]-2 (lH-indol-3-yl)-maleinimid;(-) - 2- [1- (3-Ethoxy-2-hydroxypropyl) T -hydroxy-1H-indol-S-yl] -2 (1H-indol-3-yl) -maleimide;

(-)-2-[l-(3-Ethoxy-2-hydroxypropyl)-4-trifluormethyl-lH-indol-3-yl]-2-(lH-indol-3-yl)-maleinimid;(-) - 2- [(3-ethoxy-2-hydroxypropyl) -4-l- trifluoromethyl-lH-indol-3-yl] -maleimide -2- (lH-indol-3-yl);

(-)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5-trifluormethyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(3-ethoxy-2-hydroxypropyl) -5-l- trifluoromethyl-lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

-56--56-

(-)-2-(l-(3-Ethoxy-2-hydroxypropyl)-6-trifluormethyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- (l- (3-ethoxy-2-hydroxypropyl) maleimide -6-trifluoromethyl-lH-indol-3-yl] -3- (lH-indol-3-yl);

(-)-2-[l-(3-Ethoxy-2-hydroxypropyl)-7-trifluormethyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(3-ethoxy-2-hydroxypropyl) -7-l- trifluoromethyl-lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

(-)-2-[l-(3-Ethoxy-2-hydroxypropyl)-4-methoxy-lH-indol-3-yl]-3-tlH-indol-3-yl)-maleinimid;(-) - 2- [(3-ethoxy-2-hydroxypropyl) -4-l- methoxy-lH-indol-3-yl] -3-maleimide TLH-indol-3-yl);

(-)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5-r\ethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(3-ethoxy-2-hydroxypropyl) -5-l- r \ ethoxy-lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

(-)-2-[l-(3-Ethoxy-2-hydroxypropyl)-6-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(3-ethoxy-2-hydroxypropyl) -6-methoxy-l-lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

(-)-2-[1-(3-Ethoxy-2-hydroxypropy1)-7-methoxy-IH-indol-3-y1]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [1- (3-ethoxy-2-hydroxypropy1) -7-methoxy-IH-indol-3-y1] -3- (lH-indol-3-yl) maleimide;

(-)-2-[l-(3-Ethoxy-2-hydroxypropyl)-4,5-raethylendioxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(3-ethoxy-2-hydroxypropyl) -4,5-l- raethylendioxy-lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

(-)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5,6-methylendioxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(3-ethoxy-2-hydroxypropyl) -5,6-methylenedioxy-l-lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

(-)-2-[l-(3-Ethoxy-2-hydroxypropyl)-6_/7-methylendioxy-lH-indol-3-yl ]-3-(lH-indo:i-3-yl)-maleinimid ;(-) - 2- [1- (3-Ethoxy-2-hydroxypropyl) -6 _/ 7-methylenedioxy-1H-indol-3-yl] -3- (1H-indo-i-3-yl) -maleimide;

(-)-2-tl-(3-Ethoxy-2-hydroxypropyl)-4-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2-tl (3-ethoxy-2-hydroxypropyl) -4-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5-methy^.-lH-indol-3-yl]-3-(lH-indol-3-yl) -inaleinimid;(-) - 2- [1- (3-Ethoxy-2-hydroxypropyl) -5-methyl-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(-)-2-[l-(3-Ethoxy-2-hydroxypropyl)-6-methyl-lH-indol-3-yl]-3-(lK-indol-3-yl)-maleinimid;(-) - 2- [(3-ethoxy-2-hydroxypropyl) -6-methyl-l- lH-indol-3-yl] -maleimide -3- (lK-indol-3-yl);

(-)-2-[l-(3-Ethoxy-2-hydroxypropyl)-7-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(3-ethoxy-2-hydroxypropyl) -7-l- methyl-lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

29797O -57- 29797O -57-

(-)-2-[l-(3-Ethoxy-2-hydroxypropyl)-4-nitro-iH-indol-3-yl]-3-(lH-indul-3-yl) -inaleiniinid;(-) - 2- [1- (3-Ethoxy-2-hydroxypropyl) -4-nitro-iH-indol-3-yl] -3- (1H-indul-3-yl) -allyine diimide;

(-)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5-nitro-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(3-ethoxy-2-hydroxypropyl) -5-nitro-l-lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

(-)-2-[l-(3-Ethoxy-2-hydroxypropyl)-6-nitro-lH-indol-3-yl]-3-'(lH-indol-3-yl) -maleinimid;(-) - 2- [1- (3-Ethoxy-2-hydroxypropyl) -6-nitro-1H-indol-3-yl] -3 - '(1H-indol-3-yl) -maleimide;

(-)-2-[l-(3-Ethoxy-2-hydroxypropyl)-7-nitro-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(3-ethoxy-2-hydroxypropyl) l- -7-nitro-lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

(-)-2-[l-(3-Ethoxy-2-hydroxypropyl)-4-m-vthylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(3-ethoxy-2-hydroxypropyl) -4-l- m-vthylthio-lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

(-)-2-[l-(3-Ethoxy-2-hydroxypropyl)-S-mtthylthio-lH-indol-S-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(3-ethoxy-2-hydroxypropyl) -S-l- mtthylthio-lH-indol-S-yl] -maleimide -3- (lH-indol-3-yl);

(-)-2-[l-(3-Ethoxy-2-hydroxypropyl)-6-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(3-ethoxy-2-hydroxypropyl) -6-methylthio-l-lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

(-)-2-[l-(3-Ethoxy-2-hydroxypropyl)-7-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(3-ethoxy-2-hydroxypropyl) -7-methylthio-l-lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

(-)-2-[l-(3-Ethoxy-2-hydroxypropyl)-4,5-dimethoxy-lH-indol-3-y1]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(3-ethoxy-2-hydroxypropyl) -4,5-dimethoxy-l-lH-indol-3-y1] maleimide -3- (lH-indol-3-yl);

(-)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5,e-dimethoxy-lH-indol-S-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [l- (3-ethoxy-2-hydroxypropyl) -5, e-dimethoxy-lH-indol-S-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[l-(3-Ethoxy-2-hydroxypropyl)-6,7-dimethoxy-iH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [l- (3-ethoxy-2-hydroxypropyl) -6,7-dimethoxy-iH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[4-Acetylamino-l-(2-diethylaminoethyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [4-acetylamino-l- (2-diethylaminoethyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[5-Acetylamino-l-(2-diethylaminoethyl)-lH-indol-3-yl]-3-(;LH· indol-3-yl)-maleinimid;2- [5-Acetylamino-1- (2-diethylaminoethyl) -1H-indol-3-yl] -3 - (; LH -indol-3-yl) -maleimide;

-58--58-

2- [ 6-Acetylamino-l- (2-diethylaminoethyl) -lH-indol-3-yl ] -·3- (IH-indol-3-yl)-maleinimid;2- [6-acetylamino-1- (2-diethylaminoethyl) -1H-indol-3-yl] -. 3- (IH-indol-3-yl) -maleimide;

2- [7-Acätylamino-l-( 2-diethy laminoethyl)-lH-indol-3-yl ] -2- (:.H-indol-3-yl)-maleinimid;2- [7-acetylamino-1- (2-diethylaminoethyl) -1H-indol-3-yl] -2- (: .H-indol-3-yl) -maleimide;

2-[4-Amino-1-(2-diethylaminoethyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [4-amino-1- (2-diethylaminoethyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[5-Amino-l-(2-diethylaminoethyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [5-amino-l- (2-diethylaminoethyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[6-Amino-l-(2-diethylaminoethyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [6-amino-l- (2-diethylaminoethyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[7-Amino-l-(2-diethylaminoethyl)-lH-indol-3-yl]-3-(lH-indol-3-y1)-maleinimid;2- [7-amino-l- (2-diethylaminoethyl) -lH-indol-3-yl] -3- (lH-indol-3-y1) maleimide;

2-[4-Benzyloxy-l-(2-diethylaminoethyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [4-benzyloxy-l- (2-diethylaminoethyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[5-Benzyloxy-l-(2-diethylaminoethyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [5-benzyloxy-l- (2-diethylaminoethyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[6-Benzyloxy-l-(2-diethylaminoethyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [6-benzyloxy-l- (2-diethylaminoethyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[7-Benzyloxy-l-(2-diethylaminoethyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [7-benzyloxy-l- (2-diethylaminoethyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[4-Brom-l-(2-diethylaminoethyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [4-bromo-l- (2-diethylaminoethyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[5-Brom-l-(2-diethylaminoethyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [5-bromo-l- (2-diethylaminoethyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[6-Brom-l-(2-dif»^ylaminoethyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [6-bromo-l- (2-dif »^ ylaminoethyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

-59--59-

2-(7-Brom-l-(2-diethylaminoethyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- (7-bromo-l- (2-diethylaminoethyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-^-Chlor-l-f2-diethylaminoethyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;maleimide chloro-l-f2-diethylaminoethyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) 2 - - ^;

2-[S-Chlor-l-(2-diethylaminoethyl)-lH-indol-3-yl]-j-(lH-indol ' 3-yl)-maleinimid;2- [S-chloro-1- (2-diethylaminoethyl) -1H-indol-3-yl] -j- (1H-indol-3-yl) -maleimide;

2-[6-Chlor-l-(2-diethylaminoethyl)-lH-indol-3-yl]-3-(lH-indol-3-y1)-maleinimid;2- [6-chloro-l- (2-diethylaminoethyl) -lH-indol-3-yl] -3- (lH-indol-3-y1) maleimide;

2-[7-Chlor-l-(2-diethylaminoethyl)-lH-indol-3-yl]-3-(lH-indol 3-yl)-maleinimid;2- [7-chloro-1- (2-diethylaminoethyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[l-(2-Diethylaminoethyl)-4-fluor-lH-indol-3-yl]-3-(lH-indol 3-yl)-maleinimid;2- [1- (2-diethylaminoethyl) -4-fluoro-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[l-(2-Diethylaminoethyl)-5-fluor-lH-indol-3-yl]-3-(lH-indol 3-y1)-maleinimid;2- [1- (2-diethylaminoethyl) -5-fluoro-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[1-(2-Diethylaminoethyl)-6-fluor-lH-indol-3-yl]-3-(lH-indol 3-yl)-maleinimid;2- [1- (2-diethylaminoethyl) -6-fluoro-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[l-(2-Diethylaminoethyl)-7-fluor-lR-indol-3-yl]-3-(lH-indol 3-yl)-maleinimid;2- [1- (2-diethylaminoethyl) -7-fluoro-1 R -indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[l-(2-Diethylaminoethyl)-4-hydroxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-roaleinimid;2- [l- (2-diethylaminoethyl) -4-hydroxy-lH-indol-3-yl] -3- (lH-indol-3-yl) -roaleinimid;

2-[l-(2-Diethylaminoethyl)-5-hydroxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (2-diethylaminoethyl) -5-hydroxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(2-Diethylaminoethyl)-6-hydroxy-lH-indol-3--yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (2-diethylaminoethyl) -6-hydroxy-lH-indol-3 - yl] -3- (lH-indol-3-yl) maleimide;

2-[1-(2-Diethylaminoethyl)-7-hydroxy-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (2-diethylaminoethyl) -7-hydroxy-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

-60--60-

2-(l-(2-Diethylaminoethyl)-n-trifluormethyi-lh-indoi-i-yl]-3-(lH-indol-3-yl)-maleinimid;2- (l- (2-diethylaminoethyl) -N-trifluormethyi-lh-indol-i-yl] -3- (lH-indol-3-yl) maleimide;

2-[1-(2-Diethylaminoethyl)-5-trifluormethyl-iH-indol-3-yl] -3-(lH-indol-3-yl)-maleinimid;2- [1- (2-diethylaminoethyl) -5-trifluoromethyl-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[l-(2-Diethylaminoethyl)-ö-trifluormethyl-lH-indol-S-yl]-3- (lH-indol-3-yl)-maleinimid;2- [1- (2-diethylaminoethyl) -O-trifluoromethyl-1H-indol-S-yl] -3- (1H-indol-3-yl) -maleimide;

2-[1-(2-Diethylaminoethyl)-7-trifluormethyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (2-diethylaminoethyl) -7-trifluoromethyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[1-(2-Diethylaminoethyl)-4-methoxy-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (2-diethylaminoethyl) -4-methoxy-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[1-(2-Diethylaminoethyl)-S-methoxy-lH-indol-S-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (2-diethylaminoethyl) -S-methoxy-lH-indol-S-yl] -3- (IH-indol-3-yl) maleimide;

2-[l-(2-Diethylaminoethyl)-6-methoxy-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [l- (2-diethylaminoethyl) -6-methoxy-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[l-(2-Diethylaminoethyl)-T-methoxy-lH-indol-S-yl]-3-(IH-indol-3-yl)-maleinimid;2- [l- (2-diethylaminoethyl) -T-methoxy-lH-indol-S-yl] -3- (IH-indol-3-yl) maleimide;

2-[l-(2-Diethylaminoethyl)-4,5-methylendioxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid:2- [l- (2-diethylaminoethyl) -4,5-methylenedioxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide:

2-[l-(2-Diethylaminoethyl)-5, 6-.nethylendioxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (2-diethylaminoethyl) -5,6-ethylenedioxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[l-(2-Diethylaminoethyl;-6,7-methyleniiioxy-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [l- (2-diethylaminoethyl; -6,7-methyleniiioxy-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[1-(2-Diethylaminoethyl)-4-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (2-diethylaminoethyl) -4-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(2-Diethylaminoethyl)-5-methyl-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [l- (2-diethylaminoethyl) -5-methyl-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

49797ο -6i- 49797o -6i

2-[1-(2-Diethylaminoethyl)-6-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (2-diethylaminoethyl) -6-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[1-(2-Diethylaminoethyl)-T-methyl-lH-indol-O-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (2-diethylaminoethyl) -T-methyl-lH-indol-O-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(2-Diethylaminoethyl)-4-nitro-IH-indol-3-yl]-3-(lH-indol-'3-yl)-maleinimid;2- [l- (2-diethylaminoethyl) -4-nitro-IH-indol-3-yl] -3- (lH-indol-'3-yl) maleimide;

2-[l-(2-Diethylaminoethyl)-5-nitro-lH-indol-3-yl]-3-(lK-indol-3-yl)-maleinimid;2- [l- (2-diethylaminoethyl) -5-nitro-lH-indol-3-yl] -3- (lK-indol-3-yl) maleimide;

2-[1-(2-Diethylaminoethyl)-6-nitro-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (2-diethylaminoethyl) -6-nitro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(2-Diethylaminoethyl)-7-nitro-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (2-diethylaminoethyl) -7-nitro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(2-Diethylaminoethyl)-4-methylthio-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [l- (2-diethylaminoethyl) -4-methylthio-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[ 1-(2-Diethylaminoethyl) -5-methylthio-lH-indol--3-yl]-3-(IH-indol-3-yl)-naleinimid;2- [1- (2-diethylaminoethyl) -5-methylthio-1H-indol-3-yl] -3- (1H-indol-3-yl) -naleinimide;

2-[l-(2-Diethylaminoethyl)-6-methylthio-lH-indol-3-yl]-3-(IH-indol-3-yl)-raaleinimid;2- [l- (2-diethylaminoethyl) -6-methylthio-lH-indol-3-yl] -3- (IH-indol-3-yl) -raaleinimid;

2-[1-(2-Diethylaminoethyl)-7-methylthio-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (2-diethylaminoethyl) -7-methylthio-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[1-(2-Diethylaminoethyl)-4,5-dimethoxy-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (2-diethylaminoethyl) -4,5-dimethoxy-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[l-(2-Diethylaminoethyl)-5,6-dimethoxy-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [l- (2-diethylaminoethyl) -5,6-dimethoxy-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-t1-(2-Diethylaminoethyl)-6,7-dimethoxy-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2-t1- (2-diethylaminoethyl) -6,7-dimethoxy-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

-62--62-

(±)-2-[4-Acetylamino-l-(3-diethylamino-2-hydroxypropyl;-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleiniinid;(±) -2- [4-acetylamino-l- (3-diethylamino-2-hydroxypropyl; -IH-indol-3-yl] -3- (lH-indol-3-yl) -maleiniinid;

(±)-2-[5-Acetylamino-l-(3-diethylamino-2-hydroxypropyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [5-acetylamino-l- (3-diethylamino-2-hydroxypropyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2"[6-Acätylamino-l-(3-diethylamino-2-hydroxypropyl)-IH-• indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2 "[6-acetylamino-1- (3-diethylamino-2-hydroxypropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±)-2-[7-Acetylamino-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [7-acetylamino-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[4-Amino-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [4-amino-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[5=Ainino-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indo:.-3-yl)-maleinimid;(±) -2- [5 = Ainino-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indo: .- 3-yl) maleimide;

(±)-2-[6-Amino-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [6-Amino-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[7-Amino-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [7-amino-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±) -2-[4-Benzyloxy-l-(3-diethylaTQino-2-hydroxypropyl) -lH-indol· 3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [4-Benzyloxy-1- (3-diethyl-t-quino-2-hydroxypropyl)-1H-indole-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±)-2-[5-Benzyloxy-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleininid;(±) -2- [5-benzyloxy-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) -maleininid;

(±)-2-[6-Benzyloxy-l-(3-diethylamino-2-hydroxypropyl)-lH-indol· 3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [6-Benzyloxy-1- (3-diethylamino-2-hydroxypropyl) -1H-indole-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±)-^• [7-Benzyloxy-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) - ^ • [7-Benzyloxy-1- (3-diethylamino-2-hydroxypropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

( + ) --2-[4-Brom-l-(3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [4-bromo-1- (3-diethylamino-2-hydroxypropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

-63--63-

(±)--2-[5-Brom-l-(3-diethylamino-2-hydroxypropyl)-lII-iiidol-3-yl]-3-(lH-indol-3-yl)-Tialeinimid;(±) - 2- [5-bromo-l- (3-diethylamino-2-hydroxypropyl) -LiI-iiidol-3-yl] -3- (lH-indol-3-yl) -Tialeinimid;

(±)-2-[6-Brom-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [6-bromo-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[7-Brom-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [7-bromo-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[4-Chlor-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [4-chloro-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[5-Chlor-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [5-chloro-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[6-Chlor-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [6-chloro-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[7-Chlor-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yJ)-naleinimid;(±) -2- [7-chloro-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yJ) -naleinimid;

(±)-2-[l-(3-Diethylamino-2-hydroxypropyl)-4-fluor-lH -indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [1- (3-diethylamino-2-hydroxypropyl) -4-fluoro-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±)-2-[1-(3-Diethylamino-2-hydroxypropyl)-5-fluor-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [1- (3-diethylamino-2-hydroxypropyl) -5-fluoro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(3-Diethylamino-2-hydroxypropyl)-e-fluor-lH-indol-S-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-diethylamino-2-hydroxypropyl) -e-fluoro-lH-indol-S-yl] -3- (lH-indol-3-yl) maleimide;

(±) -2-[l-(3-Diethylamino-2-hydroxypropyl) ~7-fluo?r-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [1- (3-diethylamino-2-hydroxypropyl) -7-fluoro-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±)-2-[l-(3-Diethylamino-2-hydroxypropyl)-4-hydroxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-diethylamino-2-hydroxypropyl) -4-hydroxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(3-Diethylamino-2-hydroxypropyl)-5-hydroxy-lH-indol-3· yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [1- (3-diethylamino-2-hydroxypropyl) -5-hydroxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±)-2-[l-(3-Diethylamino-2-hydroxypiropyl)-6-hydroj:y-lH-iridol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-diethylamino-2-hydroxypiropyl) -6-hydroj: y-lH-iridol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(3-Diethylamino-2-hydroxypropyl)-7-hydroxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-diethylamino-2-hydroxypropyl) -7-hydroxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(3-Diethylamino-2-hydroxypropyl)-4-trifluormethyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-diethylamino-2-hydroxypropyl) -4-trifluoromethyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(3-Diethylamino-2-hydroxypropyl)-5-trifluormetnyl-lH-indol-3-yll-3-flH-indol-3-yl)-maleiniaid;(±) -2- [l- (3-diethylamino-2-hydroxypropyl) -5-trifluormetnyl-lH-indol-3-yll-3-flH-indol-3-yl) -maleiniaid;

(±)-2-[l-(3-Diethylamino-2-hydroxypropyl)-6-trifluorMethyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-diethylamino-2-hydroxypropyl) -6-trifluoromethyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(3-Diethylamino-2-hydroxypropyl)-7-trifluormethyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimia;(±) -2- [l- (3-diethylamino-2-hydroxypropyl) -7-trifluoromethyl-lH-indol-3-yl] -3- (lH-indol-3-yl) -maleinimia;

(±)-2-[l-(3-Diethylamino-2-hydroxypropyl)-4-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-diethylamino-2-hydroxypropyl) -4-methoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(3-Diethylamino-2-hydroxyprcpyl)-eyl] -3- (lH-indol-3-yl) --maleinimid;(±) -2- [1- (3-diethylamino-2-hydroxypropyl) -eyl] -3- (1H-indol-3-yl) -maleimide;

(±)-2-[l-(3-Diethylamino-2-hydroxypropyl)-T-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-diethylamino-2-hydroxypropyl) -t-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(3-Diethylamino-2-hydroxypropyl)-4,5-methylendioxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-diethylamino-2-hydroxypropyl) -4,5-methylenedioxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(3-Diethylamino-2-hydroxypropyl)-5,6~methylendioxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-diethylamino-2-hydroxypropyl) -5,6-methylenedioxy ~ lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[1-(3-Diethylamino-2-hydroxypropyl)-6,7-methylendioxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [1- (3-diethylamino-2-hydroxypropyl) -6,7-methylenedioxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(3-Diethylamino-2-hydroxypropyl)^- yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [1- (3-diethylamino-2-hydroxypropyl) -yl] -3- (1H-indol-3-yl) -maleimide;

-6h>-6h> -

(±)-2-[l-(3-Diethylamino-2-hydroxypropyl)-5-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-diethylamino-2-hydroxypropyl) -5-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±) -2-[l-(3-Diethylamino-2-hydroxypropy.l)-6-methyl-lH-indol-3-yl ] -3- (lH--indol-3-yl) -maleinimid;(±) -2- [1- (3-diethylamino-2-hydroxypropyl) -6-methyl-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±)-2-[l-(3-Diethylamino-2-hydroxypropyl)-T-. yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-diethylamino-2-hydroxypropyl) -T-. maleimide yl] -3- (lH-indol-3-yl);

(±)-2-[l-(3-Diethylamino-2-hydroxypropyl)-4-nitro-lH-indol-3 yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [1- (3-diethylamino-2-hydroxypropyl) -4-nitro-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±)-2-[l-(3-Diethylamino-2-hydroxypropyl)-S-nitro-lH-indol-S yl]-3-(lH-indol-3-yl)-maleinimid ?(±) -2- [1- (3-Diethylamino-2-hydroxypropyl) -S-nitro-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide?

(±)-2-[l-(3-Diethylamino-2-hydroxypropy1)-e-nitro-lH-indol-S yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [1- (3-diethylamino-2-hydroxypropyl) -e-nitro-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±)-2-[l-(3-Diethylamino-2-hydroxypropyl)-7-nitro-lH-indol-3 y1]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [1- (3-diethylamino-2-hydroxypropyl) -7-nitro-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±)-2-[l-(3-Diethylamino-2-hydroxypropyl)-4-methylthio-lH-indol-.i-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-diethylamino-2-hydroxypropyl) -4-methylthio-lH-indol-.i-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(3-Diethylamino-2-hydroxypropyl)-5-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid?(±) -2- [l- (3-diethylamino-2-hydroxypropyl) -5-methylthio-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide?

(±)-2--p.-(3-Diethylamino-2-hydroxypropyl)-6-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2 - p .- (3-diethylamino-2-hydroxypropyl) -6-methylthio-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(3-Diethylamino-2-hydroxypropyl)-7-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-diethylamino-2-hydroxypropyl) -7-methylthio-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(3-Diethylamino-2-hydroxypropy1)-4,5-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-diethylamino-2-hydroxypropy1) -4,5-dimethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(3-Diethylamino-2-hydroxypropyl)-5,6-dimethoxy-lH-indol-3-yl]-3-Ci.H-indol-3-yl)-maleinimid;(±) -2- [l- (3-diethylamino-2-hydroxypropyl) -5,6-dimethoxy-lH-indol-3-yl] -3-Ci.H-indol-3-yl) maleimide;

-66--66-

(±)-2-[l-(3-Diethylamino-2-hydroxypropyl)-6,7-dimeLhoxy-lH indol-3-yl]-3-(lK-indol-3-yl)-maleinimid;(±) -2- [1- (3-diethylamino-2-hydroxypropyl) -6,7-dimethoxy-1H-indol-3-yl] -3- (1K-indol-3-yl) -maleimide;

-2-[4-Acetylamino-l-(3-diethylamino-2-hydroxypropyl)--1H indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;-2- [4-acetylamino-1- (3-diethylamino-2-hydroxypropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[5-Acetylamino-l-(3-diethylamino-2-hydroxypropyl)-IH indol-3-y"i.'"3-(lH-indol-3-yl) -maleinimid;(+) - 2- [5-Acetylamino-1- (3-diethylamino-2-hydroxypropyl) -IH-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

( + )-2-[6-Acetylamino-l-(3-diethy.lamino-2-hydroxypropyl) -IH indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) -2- [6-Acetylamino-1- (3-diethylamino-2-hydroxypropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

-2-[7-Acetylamino-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;-2- [7-acetylamino-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[4-Amino-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [4-amino-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[5-Amino-l-(3-diethylamino-2-hydroxypropyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [5-Amino-l- (3-diethylamino-2-hydroxypropyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[6-Amino-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [6-amino-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[7-Amino-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [7-amino-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[4-Benzyloxy-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [4-benzyloxy-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

-2-[5-Benzyloxy-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;-2- [5-benzyloxy-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[6-Benzyloxy-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [6-benzyloxy-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[7-Benzyloxy-i-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinJ.aiid;(+) - 2- [7-benzyloxy-i- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) -maleinJ.aiid;

-67--67-

( + )-2-[4-Brom-l-(3-diethylaminO"2-hydroxypx.-opyi)-iH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) -2- [4-Bromo-1- (3-diethylaminoO "2-hydroxypoxy-opyl) -iH-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[5-Brom-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-?- yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [5-bromo-1- (3-diethylamino-2-hydroxypropyl) -1H-indol-.-Yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[6-Brom-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [6-bromo-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[7-Brom-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [7-bromo-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[4-Chlor-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [4-chloro-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[5-Chlor-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [5-chloro-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[6-Chlor-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [6-chloro-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[7-Chlor-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [7-chloro-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(3-Diethylamino-2-hydroxypropyl)-4-fluor-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-diethylamino-2-hydroxypropyl) -4-fluoro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(3-Diethylamino-2-hydroxypropyl)-5-fluor-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-diethylamino-2-hydroxypropyl) -5-fluoro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(3-Diethylamino-2-hydroxypropyl)-6-fluor-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-diethylamino-2-hydroxypropyl) -6-fluoro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

-2-[l-(3-Diethylamino-2-hydroxypropyl)-7-fluor-lH-indol-3-yl]-3~(lH-indol-3-yl)-maleinimid;-2- [l- (3-diethylamino-2-hydroxypropyl) -7-fluoro-lH-indol-3-yl] -3 ~ (lH-indol-3-yl) maleimide;

(+)-2-[l-(3-Diethylamino-2-hydroxypropyl)-4-hydroxy-lH-indol-3· yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [1- (3-diethylamino-2-hydroxypropyl) -4-hydroxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

-68--68-

( + )-2-[l-(3-Diethylamino-2-hydi.-oxypropyl)-5-hydroxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) -2- [1- (3-diethylamino-2-hydroxy-oxypropyl) -5-hydroxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[l-(3-Diethylamino-2-hydroxypropyl)-G-hydroxy-lH-indol-S-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-diethylamino-2-hydroxypropyl) -G-hydroxy-lH-indol-S-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(3-Diethylamino-2-hydroxypropyl)-7-hydroxy-lH-indol-3-.yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-diethylamino-2-hydroxypropyl) -7-hydroxy-lH-indol-3-.yl] -3- (lH-indol-3-yl) maleimide;

( + )-2-[l-(3-Diethylcimino-2-hydroxypropyl)-4-trifluormethyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) -2- [1- (3-diethylcimino-2-hydroxypropyl) -4-trifluoromethyl-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[l-(3-Diethylamino-2-hydroxypropyl)-5-trifluormethyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-diethylamino-2-hydroxypropyl) -5-trifluoromethyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(3-Diethylamino-2-hydroxypropyl)-6-trifluormethyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-diethylamino-2-hydroxypropyl) -6-trifluoromethyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(3-Diethylamino-2-hydroxypropyl)-7-trifluormethyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-diethylamino-2-hydroxypropyl) -7-trifluoromethyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(3-Diethylamino-2-hydroxypropyl)-4-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-diethylamino-2-hydroxypropyl) -4-methoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(3-Diethylamino-2-hydroxypropyl)-5-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-diethylamino-2-hydroxypropyl) -5-methoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(3-Diethylamino-2-hydroxypropyl)-6-methoxy-lH-indol-3-0 y1]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [1- (3-diethylamino-2-hydroxypropyl) -6-methoxy-1H-indol-3-O-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[l-(3-Diethylamino-2-hydroxypropyl)-7-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-diethylamino-2-hydroxypropyl) -7-methoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[1-(3-Diethylamino-2-hydroxypropyl)-4,5-methylendioxy-lH· indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [1- (3-diethylamino-2-hydroxypropyl) -4,5-methylenedioxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[l-(3-Diethylamino-2-hydroxypropyl)-5,6-methylendioxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-diethylamino-2-hydroxypropyl) -5,6-methylenedioxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

-69--69-

(+)-2-[l-(3-Diethylamino-2-hydioxypropyl;-6,7-methylendioxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-diethylamino-2-hydioxypropyl; -6,7-methylenedioxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(3-Diethylamino-2-hydroxypropyl)-4-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-diethylamino-2-hydroxypropyl) -4-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[.i-(3-Diethylamino-2-hydroxypropyl)-5-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2 - -3- (lH-indol-3-yl) maleimide; [i- (3-diethylamino-2-hydroxypropyl) -5-methyl-lH-indol-3-yl.]

(+)-2-[l-(3-Diethylamino-2-hydroxypropyl)-6-methyl-lH-indol-3-yl]-3-(lH-indol~3-yl)-maleinimid;(+) - 2- [l- (3-diethylamino-2-hydroxypropyl) -6-methyl-lH-indol-3-yl] -3- (lH-indol ~ 3-yl) maleimide;

(+)-2-[l-(3-Diethylamino-2-hydroxypropyl)-7-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-diethylamino-2-hydroxypropyl) -7-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(3-Diethylamino-2-hydroxypropyl) -4-ni<,:ro-lH-indol-3-yl]-3-(lH-indol-3~yl)-maleinimid;(+) - 2- [1- (3-diethylamino-2-hydroxypropyl) -4-ni <: ro-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[l-(3-Diethylamino-2-hydroxypropyl)-S-nitro-lH-indol-S-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-diethylamino-2-hydroxypropyl) -S-nitro-lH-indol-S-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(3-Diethylamino-2-hydroxypropyl)-6-nitro-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-diethylamino-2-hydroxypropyl) -6-nitro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[1-(3-Diethylamino-2-hydroxypropyl)-V-nitro-lH-indol-S-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [1- (3-diethylamino-2-hydroxypropyl) -V-nitro-lH-indol-S-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(3-Diethylamino-2-hydroxypropyl)-4-methylthio-lH-indol-3-yl]-3-(lH~indol-3-yl)-maleinimid;(+) - 2- [l- (3-diethylamino-2-hydroxypropyl) -4-methylthio-lH-indol-3-yl] -3- (lH ~ indol-3-yl) maleimide;

(+)-2-[1-(3-Diethylamino-2-hydroxypropyl)-5-methylthio-lH-indcl-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [1- (3-diethylamino-2-hydroxypropyl) -5-methylthio-lH-indcl-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(3-Diethylamino-2-hydroxypropyl)-6-methylthio-lH-indol O-(+) - 2- [1- (3-diethylamino-2-hydroxypropyl) -6-methylthio-1H-indole O-

(+)-2-[l-(3-Diethylamino-2-hydroxypropyl)-7-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-diethylamino-2-hydroxypropyl) -7-methylthio-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2379?° -ve- 2379? ° -ve

(+)-2-[1-(3-Diethylamino-2-hydroxypropyl)-4,5-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [1- (3-diethylamino-2-hydroxypropyl) -4,5-dimethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(3-Diethylamino-2-hydroxypropyl)-5,6-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-diethylamino-2-hydroxypropyl) -5,6-dimethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(3-Diethylamino-2-hydroxypropyl)-6,7-dimethoxy-lH-•indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-diethylamino-2-hydroxypropyl) -6,7-dimethoxy-LH • indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[4-Acetylaraino-l-(3-diethylamino-2-hydroxypropyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [4-Acetylaraino-l- (3-diethylamino-2-hydroxypropyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[5-Acetylamino-l-(3-diethylamino-2-hydroxypropy1)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [5-Acetylamino-l- (3-diethylamino-2-hydroxypropy1) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2 -[6-Acetylamino-l-(3-diethylamino-2-hydroxypropyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)"maleinimid;(-) - 2 - [6-Acetylamino-1- (3-diethylamino-2-hydroxypropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(-)-2-[7-Acetylamino-l-(3-diethylamino-2-hydroxypropyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maloinimid;(-) - 2- [7-acetylamino-l- (3-diethylamino-2-hydroxypropyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) -maloinimid;

(-)-2-[4-Amino-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [4-amino-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[5-Amino-l~(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [5-amino-l ~ (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[6-Amino-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [6-amino-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[7-Amino-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [7-amino-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[4-Benzyloxy-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [4-benzyloxy-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[5-Benzyloxy-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [5-benzyloxy-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

-71--71-

(-) -2-[6-Benzyloxy-l-(3-diethyiamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) -2- [6-Benzyloxy-1- (3-diethylamino-2-hydroxypropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(-)-2-[7-Benzyloxy-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimi"· (-) - 2- [7-Benzyloxy-1- (3-diethylamino-2-hydroxypropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimine "

(-) -2-[4-Brom-l-(3-diethylamino-2~hydroxypropyl)-iH-indol-3-.yl]-3-(lH-indol-3-yl)-maleinimid;(-) -2- [4-Bromo-1- (3-diethylamino-2-hydroxypropyl) -iH-indol-3-.yl] -3- (1H-indol-3-yl) -maleimide;

(-)-2-[5-Brom-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [5-bromo-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[6-Brom-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [6-bromo-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[7-Brom-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [7-bromo-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[4-Chlor-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [4-chloro-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[5-Chlor-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [5-chloro-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[6-Chlor-l-(3-diethylamino-2-bydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [6-chloro-l- (3-diethylamino-2-bydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[7-Chlor-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [7-chloro-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

(-)-2-[l-(3-Diethylamino-2-hydroxypropyl)-4-fluor-lH-indcl-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(3-diethylamino-2-hydroxypropyl) -4-fluoro-l- lH-indcl-3-yl] -maleimide -3- (lH-indol-3-yl);

(-)-2-[l-(3-Diethylamino-2-hydroxypropyl)-5-fluor-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(3-diethylamino-2-hydroxypropyl) -5-fluoro-l-lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

(-)-2-[l-(3-Diethylamino-2-hydroxypropyl)-6-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [l- (3-diethylamino-2-hydroxypropyl) -6-yl] -3- (lH-indol-3-yl) maleimide;

-72--72-

(-)-2-[l-(3-Diethylamino-2-hyaroxypropyl)-T-l yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [1- (3-Diethylamino-2-hyaroxypropyl) -T-1-yl] -3- (1H-indol-3-yl) -maleimide;

(-)-2-[l-(3-Diethylamino-2-hydroxypropyl)-4-hydroxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(3-diethylamino-2-hydroxypropyl) -4-hydroxy-l-lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

(-)-2-[l-(3-Diethylamino-2-hydroxypropyl)-S-hydroxy-lH-indol-S-. yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [l- (3-diethylamino-2-hydroxypropyl) -S-hydroxy-lH-indole-S-. maleimide yl] -3- (lH-indol-3-yl);

(-)-2-[l-(3-Diethylamino-2-hydroxypropyl)-6-hydroxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(3-diethylamino-2-hydroxypropyl) -6-hydroxy-l-lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

(-)-2-[l-(3-Diethylamino-2-hydroxypropyl)-7-hydroxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(3-diethylamino-2-hydroxypropyl) l- -7-hydroxy-lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

(-)-2-[l-(3-Diethylamino-2-hydroxypropyl)-4-trifluormethyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(3-diethylamino-2-hydroxypropyl) -4-l- trifluoromethyl-lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

(-)-2-[l-(3-Diethylamino-2-hydroxypropyl)-5-trifluormethyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(3-diethylamino-2-hydroxypropyl) -5-l- trifluoromethyl-lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

(-)-2-[l-(3-Diethylamino-2-hydroxypropyl)-6-trifluormethyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(3-diethylamino-2-hydroxypropyl) -6-l- trifluoromethyl-lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

(-)-2-[l-(3-Diethylamino-2-hydroxypropyl)-7-trifluormethyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(3-diethylamino-2-hydroxypropyl) -7-l- trifluoromethyl-lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

(-)-2-[l-(3-Diethylamino-2-hydroxypropyl)-4-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(3-diethylamino-2-hydroxypropyl) -4-l- methoxy-lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

(-)-2-[l-(3-Diethylamino-2-hydroxypropyl)-S-methoxy-lH-indol-S-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(3-diethylamino-2-hydroxypropyl) l -S-methoxy-lH-indol-S-yl] -maleimide -3- (lH-indol-3-yl);

(-)-2-[l-(3-Diethylamino-2-hydroxypropyl)-ö-methoxy-lH-indol-S-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(3-diethylamino-2-hydroxypropyl) -o l-methoxy-lH-indol-S-yl] -maleimide -3- (lH-indol-3-yl);

(-)-2-[l-(3-Diethylamino-2-hydroxypropyl)-V-methoxy-lH-indol-S-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(3-diethylamino-2-hydroxypropyl) -V l--methoxy-lH-indol-S-yl] -maleimide -3- (lH-indol-3-yl);

-73--73-

(-)-2-[l-(3-Diethylamino-2-hydioxypropylj-4,5-methylendioxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [l- (3-diethylamino-2-hydioxypropylj-4,5-methylenedioxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-fl-(3-Diethylamino-2-hydroxypropyl)-5,6-methylendioxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2-fl- (3-diethylamino-2-hydroxypropyl) maleimide -5,6-methylenedioxy-lH-indol-3-yl] -3- (lH-indol-3-yl);

(-)-2-[1-(3-Diethylamino-2-hydroxypropyl)-6,7-methylendioxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [1- (3-diethylamino-2-hydroxypropyl) -6,7-methylenedioxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[l-(3-Diethylamino-2-hydroxypropyl) ^-methyl.-lH-indol-S-yl]-3-(lH-indol-3-yl)-maleinimid,·(-) - 2- [1- (3-Diethylamino-2-hydroxypropyl) -1-methyl-1H-indol-5-yl] -3- (1H-indol-3-yl) -maleimide.

(-)-2-[l-(3-Diethylamino-2-hydroxypropyl)-S-methyl-lH-indol-S-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(3-diethylamino-2-hydroxypropyl) l -S-methyl-lH-indol-S-yl] -maleimide -3- (lH-indol-3-yl);

(-)-2-[l-(3-Diethylamino-2-hydroxypropyl)-6~methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [l- (3-diethylamino-2-hydroxypropyl) -6 ~ methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[l-(3-Diethylan:ino-2-hydroxypropyl)-7-methyl-lH~indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [l- (3-Diethylan: ino-2-hydroxypropyl) -7-methyl-lH ~ indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[l-(3-Diethylamino-2-hydroxypropyl)-4-nitrc-lH-indol-3-yl]-3-(lH-inQDl-3-yl)-maleinimid;(-) - 2- [(3-diethylamino-2-hydroxypropyl) -4-nitrc-l- lH-indol-3-yl] -maleimide -3- (lH-inQDl-3-yl);

(-) -2-[l- (3-Diethylamino-2-hydroxypropyl) -S-nitro-lH-iridolO-yl ]-3-(l:.T"indol-3-yl)-maleinimid;(-) -2- [1- (3-diethylamino-2-hydroxypropyl) -S-nitro-1H-iridol O-yl] -3- (1: t-indol-3-yl) -maleimide;

(-)-2-[l-(3-Diethylamino-2-hydroxypropyl)-e-nitro-lH-0 y1]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [1- (3-Diethylamino-2-hydroxypropyl) -e-nitro-1H-O-yl] -3- (1H-indol-3-yl) -maleimide;

(-)-2-[l-(3-Diethylamino-2-hydroxypropyl)-7-nitro-lH-indol-3 yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [1- (3-Diethylamino-2-hydroxypropyl) -7-nitro-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(-)-2-[l-(3-Diethylamino-2-hydroxypropyl)-4-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(3-diethylamino-2-hydroxypropyl) -4-methylthio-l-lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

(-)-2-[l-(3-Diethylamino-2-hydroxypropyl)-5-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(3-diethylamino-2-hydroxypropyl) -5-methylthio-l-lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

(-)-2-[l-(3-Diethylamino-2-hydroxypropyl)-6-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(3-diethylamino-2-hydroxypropyl) -6-methylthio-l-lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

(-)-2-[l-(3-Diethylamino-2-hydroxypropyl)-7-methylthio-lH-ir.dol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(3-diethylamino-2-hydroxypropyl) -7-methylthio-l-lH-ir.dol-3-yl] -maleimide -3- (lH-indol-3-yl);

(-)-2-[l-(3-Diethylamino-2-hydroxypropyl)-4,5-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(3-diethylamino-2-hydroxypropyl) -4,5-dimethoxy-l-lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

(-) -2-[l-(3-Diethylamino-2-hydroxypropyl) -5, 6-diraethoxy--lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) -2- [1- (3-diethylamino-2-hydroxypropyl) -5,6-direthoxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(-)-2-[l-(3-Diethylamino-2-hydroxypropyl)-6,7-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-naleinimid;(-) - 2- [(3-diethylamino-2-hydroxypropyl) -6,7-dimethoxy-l-lH-indol-3-yl] -naleinimid -3- (lH-indol-3-yl);

2-[4-Acetylamino-l-(3-diethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)·naleinimid;2- [4-acetylamino-l- (3-diethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) · naleinimid;

2-[5-Acetylamino-l-(3-diethylaminopropyl)-lH-indol-3-yl]-3-(IH-indol-3~yl)-maleinimid;2- [5-Acetylamino-l- (3-diethylaminopropyl) -lH-indol-3-yl] -3- (IH-indol-3 ~ yl) maleimide;

2-[6-Acetylamino-l-(3-diethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [6-acetylamino-l- (3-diethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[7-Acetylamino-l-(3-diethylaminopropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;maleimide 2- [7-acetylamino-l- (3-diethylaminopropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl);

2-[4-Amino-l-(3-diethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [4-amino-l- (3-diethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[5-Amino-l-(3-diethylaminopropyl)-lH-indol-3~yl]-3-(lH-indol-3-yl)-maleinimid;2- [5-Amino-l- (3-diethylaminopropyl) -lH-indol-3 ~ yl] -3- (lH-indol-3-yl) maleimide;

2-[6-Amino-l-(3-diethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [6-amino-l- (3-diethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[7-Amino-l-(3-diethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;maleimide 2- [7-amino-l- (3-diethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl);

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2-[4-Benzyloxy-l-(3-diethylaminoprOpyl)-lh-inaol-3-ylj-3-(IH-indol-3-yl) -inaleinimid;2- [4-Benzyloxy-1- (3-diethylaminoprOpyl) -1h-inaol-3-ylj-3- (IH-indol-3-yl) -maleimide;

2-(5-Benzyloxy-l-(3-diethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- (5-benzyloxy-l- (3-diethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[6-Benzyloxy-l-(3-diethylaminopropyl)-lH-indol-3-yl]-3-(lH- indol-3-yl) -maleinimid;2- [6-Benzyloxy-1- (3-diethylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[7-Benzyloxy-l-(3-diethylaminopiOpyl)-lK-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;maleimide 2- [7-benzyloxy-l- (3-diethylaminopiOpyl) -LK-indol-3-yl] -3- (lH-indol-3-yl);

2-[4-Brom-l-(3-diethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [4-bromo-l- (3-diethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[5-Brom-l-(3-diethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [5-bromo-l- (3-diethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[6-Brom-l-(3-diethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [6-bromo-l- (3-diethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[7-Brom-l-(3-diethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;maleimide 2- [7-bromo-l- (3-diethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl);

2-[4-Chlor-l-(3-diethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [4-chloro-l- (3-diethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

3-yl)-maleinimid;3-yl) maleimide;

2-[7-Chlor-l-(3-Diethylaminopropyl)-lH"indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [7-chloro-l- (3-diethylaminopropyl) -lH "indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-Diethylaminopropyl)-4-flaor-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-diethylaminopropyl) -4-flaor-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

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2-[l-(3-Diethylaminopropyl)-5-fluor-lH-indol-2-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-diethylaminopropyl) -5-fluoro-lH-indol-2-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-Diethylaminopropyl)-6-fluor-lH-indol-3-yl]-3-(lH-indol-3-y1)-maleinimid;2- [l- (3-diethylaminopropyl) -6-fluoro-lH-indol-3-yl] -3- (lH-indol-3-y1) maleimide;

2-[l-(3-Diethylaminopropyl)-7-fluor-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-diethylaminopropyl) -7-fluoro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[1-(3-Diethylaminopropyl)-4-hydroxy-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (3-diethylaminopropyl) -4-hydroxy-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[l-(3-Diethylaminopropyl)-5-hydroxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-diethylaminopropyl) -5-hydroxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2~[l-(3-Diethylaminopropyl)-6-hydroxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2 ~ [l- (3-diethylaminopropyl) -6-hydroxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-Diethylaminopropyl)-7-hydroxy-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [l- (3-diethylaminopropyl) -7-hydroxy-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[l-(3-Diethylaminopropyl)-4-trifluormethyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-diethylaminopropyl) -4-trifluoromethyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-Diethylaminopropyl)-5-trifluormethyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-diethylaminopropyl) -5-trifluoromethyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2~[l-(3-Diethylaminopropyl)-6-trifluormethyl-lH-indol-3-yl]-3-(lH~indoi-3-yl)-maleinimid;2 ~ [l- (3-diethylaminopropyl) -6-trifluoromethyl-lH-indol-3-yl] -3- (lH ~ indol-3-yl) maleimide;

2-[l-(3-Diethylaminopropyl)-7-trifluormethyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-diethylaminopropyl) -7-trifluoromethyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-Diethylaminopropyl)-4-methoxy-lH-ind61-3-yl]-3-(lH-indol-3-yl) -iualeinimid;2- [1- (3-diethylaminopropyl) -4-methoxy-1H-indinyl-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[l-(3-Diethylaminopropyl)-6-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-diethylaminopropyl) -6-methoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

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2-[l-(3-Diethylaminopropyl)-7-methoxy-lH-indoi-3-yl]-j-(1H-indol-3-yl)-maleinimid;2- [l- (3-diethylaminopropyl) -7-methoxy-lH-indol-3-yl] -j- (1H-indol-3-yl) maleimide;

2-[1-(3-Diethylaminopropyl)-4,5-methylendioxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (3-diethylaminopropyl) -4,5-methylenedioxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-Diethylaminopropyl)-5,6-methylendioxy-lH-indol-3-yl]-3-• (lH-indol-3-yl)-maleinimid;2- [1- (3-diethylaminopropyl) -5,6-methylenedioxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[ 1- (3'-Diethylaminopropyl) -6,7-methylendioxy-lH-indol-3-yl] -3-(lH-indol-3-yl)-maleinimid;2- [1- (3'-diethylaminopropyl) -6,7-methylenedioxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[l-(3-Diethylaminopropyl)-4-methyl-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [l- (3-diethylaminopropyl) -4-methyl-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[1-(3-Diethylaminopropyl)-5-methyl-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (3-diethylaminopropyl) -5-methyl-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[l-{3-Diethylaminopropyl)-6-methyl-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [l- {3-diethylaminopropyl) -6-methyl-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[l-(3-Diethylaminopropyl)-7-methyl-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [l- (3-diethylaminopropyl) -7-methyl-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[l-(3-Diethylaminopropyl)-4-nitro-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-diethylaminopropyl) -4-nitro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-Diethylaminopropyl)-5-nitro-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-diethylaminopropyl) -5-nitro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-Diethylaminopropyl)-6-nitro-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-diethylaminopropyl) -6-nitro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[1-{3-Diethylaminopropyl)-V-nitro-lH-indol-S-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- {3-diethylaminopropyl) -V-nitro-lH-indol-S-yl] -3- (lH-indol-3-yl) maleimide;

5 2-[l-(3-Diethylami;.ropropyl)-4-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;5 2- [1- (3-diethylamino-propyl) -4-methylthio-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

_₇₈__ ₇₈ _

2-[l-(3-Diethylaminopropyl)-5-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-diethylaminopropyl) -5-methylthio-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-Diethylaminopropyl)-6-methylthio-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [l- (3-diethylaminopropyl) -6-methylthio-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[l-(3-Diethylaminopropyl)-7-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-diethylaminopropyl) -7-methylthio-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-Diethylaminopropyl)-4,5-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-diethylaminopropyl) -4,5-dimethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-D.iethylaminopropyl)-5,6-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-y.l)-maleinimid;2- [l- (3-D.iethylaminopropyl) -5,6-dimethoxy-lH-indol-3-yl] -3- (lH-indol-3-y.l) maleimide;

2-[l-(3-Diethylaminopropyl)-6,7-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl) -nnaleinimid;2- [1- (3-diethylaminopropyl) -6,7-dimethoxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -nalalimide;

2-[4-Acetylamino-l-(3-ethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [4-acetylamino-l- (3-ethylaminopropyl) -lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

2-[5-Acetylamino-l-(3-ethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [5-Acetylamino-l- (3-ethylaminopropyl) -lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

2-[6-Acetylamino-l-(3-ethylaiainopropyi)-lH-indol-3-yl]-3"(lH-indol-3-yl)-maleinimid;2- [6-acetylamino-l- (3-ethylaiainopropyi) -lH-indol-3-yl] -maleimide -3 "(lH-indol-3-yl);

2-[7-Acetylamino-l-(3-ethylaminop]opyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [7-acetylamino-l- (3-ethylaminop] opyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[4-Amino-l-(3-ethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [4-amino-l- (3-ethylaminopropyl) -lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

2-t5-Amino-l-(3-ethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2-t5-amino-l- (3-ethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[6-Amino-l-(3-ethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [6-amino-l- (3-ethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

-79--79-

2-[7-Amino-l-(3-ethylaminopropyl) -lH--indol-3 -yl] -3-(lH-indol-3-yl)-maleinimid;2- [7-amino-1- (3-ethylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[4-Benzyloxy-l-(3-ethylaminopropyl)-iH-indol-3-yl]-3-(1H-indol-3-yl)-maleinimid;2- [4-benzyloxy-l- (3-ethylaminopropyl) -IH-indol-3-yl] -3- (1H-indol-3-yl) maleimide;

2-[5-Benzyloxy-l-(3-ethylaminopropyl)-lH-indol-3-yl]-3-(IH- -indol-3-yl)-maleinimid;2- [5-Benzyloxy-1- (3-ethylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[6-Benzyloxy-l"(3-ethylaminopropyl)-lH~indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [6-benzyloxy-l "(3-ethylaminopropyl) -lH ~ indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[7-Benzyloxy-l-(3-ethylaminopropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [7-benzyloxy-l- (3-ethylaminopropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[4-Brom-l-(3-ethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [4-bromo-l- (3-ethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[5-Brom-l-(3-ethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [5-bromo-l- (3-ethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[6-Brom-l-(3-ethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [6-bromo-l- (3-ethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[7-Brom-l-(3-ethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [7-bromo-l- (3-ethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[4-Chlor-l-(3-ethylaminopropyl)-lH-indol-3-yl]-3-(1Η-ίη·:ίο1-3-yl)-maleinimid;2- [4-chloro-l- (3-ethylaminopropyl) -lH-indol-3-yl] -3- (1Η-ίη ·: ίο1-3-yl) maleimide;

2-[5-Chlor-l-(3-ethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3 yl)-maleinimid;2- [5-chloro-1- (3-ethylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[6-Chlor-l-(3-ethylaminopropyl)-lH-indol-3-yl]-3-(lH-ir:dol-3-yl)-maleinimid;2- [6-chloro-l- (3-ethylaminopropyl) -lH-indol-3-yl] -3- (lH-ir: dol-3-yl) maleimide;

2-[7-Chlor-l-(3-ethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [7-chloro-l- (3-ethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

-80--80-

2-[l-(3-Ethylaminopropyl)-4-fluor-lK-indol-3 -yl] -3-(lH-indol-3-yl)-maleinimid;2- [1- (3-ethylaminopropyl) -4-fluoro-1K-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[l-(3-Ethylaminopropyl)-5-fluor-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-ethylaminopropyl) -5-fluoro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-Ethylaminopropyl)-6-fluor-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-ethylaminopropyl) -6-fluoro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[1-(3-Ethylaminopropyl)-7-fluor-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (3-ethylaminopropyl) -7-fluoro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-Ethylaminopropyl)-4-hydroxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-ethylaminopropyl) -4-hydroxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-Ethylaminopropyl)-5-hydroxy-lH-indol-3-yl]-3-(lH-indol-3-y1)-maleinimid;2- [l- (3-ethylaminopropyl) -5-hydroxy-lH-indol-3-yl] -3- (lH-indol-3-y1) maleimide;

2-[1-(3-Ethylaminopropyl)-6-hydroxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (3-ethylaminopropyl) -6-hydroxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2- [ 1- (3-Ethylaminopropyl) -'; -hydroxy-lH-indol-3-yl ] -3- (IH-indol-3-yl)-maleinimid;2- [1- (3-ethylaminopropyl) - '; -hydroxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[1-(3-Ethylaminopropyl)-4-trifluormethyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (3-ethylaminopropyl) -4-trifluoromethyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-( 3-Ethylaminopropyl )-5--trifluormethyl-lH-indo.¹.-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (3-ethylaminopropyl) -5-trifluoromethyl-1H-indo. . ^1-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-Ethylaminopropyl)-6-trifluormethyl-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [l- (3-ethylaminopropyl) -6-trifluoromethyl-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[l-(3-Ethylaminopropyl)-7-trifluormethyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-ethylaminopropyl) -7-trifluoromethyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-Ethylaminopropyl)-4-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-ethylaminopropyl) -4-methoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[1-(3-Ethylaminopropyl)-5-methoxy-lH-inddi-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (3-ethylaminopropyl) -5-methoxy-lH-inddi-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-Ethylaminopropyl)-6-methoxy~lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-ethylaminopropyl) -6-methoxy ~ lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-Ethylaminopropyl)-7-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-ethylaminopropyl) -7-methoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-Ethylaminopropyl)-4,5-methylendioxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-ethylaminopropyl) -4,5-methylenedioxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[1-(3-Ethylaminopropyl)-5,6-methylendioxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (3-ethylaminopropyl) -5,6-methylenedioxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[1-(3-Ethylaminopropyl)-6,7-methylendioxy-lH-indol-3-yl]-3-(IH-indol-3-y1)-maleinimid;2- [1- (3-ethylaminopropyl) -6,7-methylenedioxy-lH-indol-3-yl] -3- (IH-indol-3-y1) maleimide;

2-[1-(3-Ethylaminopropyl)-4-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (3-ethylaminopropyl) -4-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-Ethylaminopropyl)-5-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-ethylaminopropyl) -5-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-Ethylaminopropyl)-6-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-ethylaminopropyl) -6-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-Ethylaminopropyl)-7-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-ethylaminopropyl) -7-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-Ethylaminopropyl)-4-nitro-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-ethylaminopropyl) -4-nitro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-Ethylaminopropyl)-S-nitro-lH-indol-S-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-ethylaminopropyl) -S-nitro-lH-indol-S-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-Ethylaminopropyl)-6-nitro-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-ethylaminopropyl) -6-nitro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

297 9 ?o297 9? O

-82--82-

2-[1-(3-Ethylaminopropyl)-7-nitrO"lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (3-ethylaminopropyl) -7-Nitro "lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[l-(3-Ethylaminopropyl)-4-methylthio-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [l- (3-ethylaminopropyl) -4-methylthio-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[1-(3-Ethylaminopropyl)-S-methylthio-lH-indol-S-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (3-ethylaminopropyl) -S-methylthio-lH-indol-S-yl] -3- (IH-indol-3-yl) maleimide;

2-[ 1- (3-Ethylaminopropyl) -ö-methylthio-lH-indol^-yl]-3- (IH-indol-3-yl)-maleinimid;2- [1- (3-ethylaminopropyl) -omethylthio-1H-indol-1-yl] -3- (1H-indol-3-yl) -maleimide;

2-[l-(3-Ethylaminopropyl)^-raethylthio-lH-indol-S-yl]-3-(IH-indoI-3-yJ.)-maleinimid;2- [l- (3-ethylaminopropyl) ^ - raethylthio-lH-indol-S-yl] -3- (IH-indol-3-yJ.) - maleimide;

2-[1-(3-Sthylaminopropy1)-4,5-dimethoxy-lH-indol-3-yl]-3-(IH-indol--3-yl) -maleinimid;2- [1- (3-Methylaminopropyl) -4,5-dimethoxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[l-(3-Ethylaminopropyl)-5,6-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-ethylaminopropyl) -5,6-dimethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-Ethylaminopropyl)-6,7-dimethoxy-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [l- (3-ethylaminopropyl) -6,7-dimethoxy-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

(±) -2-[4-Acetylamino-l-(2-hydroxy-3-dimethylamir.opropyl) -IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [4-Acetylamino-1- (2-hydroxy-3-dimethylamiropropyl) -IH-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±)-2-[5-Acetylamino-l-(2-hy-Jroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [5-acetylamino-l- (2-hy-Jroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[6-Acetylamino-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [6-acetylamino-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[7-Acetylamino-l-(2-hydroxy-3-dimethylaminopropyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [7-acetylamino-l- (2-hydroxy-3-dimethylaminopropyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[4-Amino-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3 yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [4-amino-1- (2-hydroxy-3-dimethylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

-83--83-

(±)-2-[5-Amino-l-(2-hydroxy-3-diincrnyiamiriopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [5-amino-l- (2-hydroxy-3-diincrnyiamiriopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[6-Amino-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maluinimid;(±) -2- [6-amino-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) -maluinimid;

(±) -2-[7-Amino-l- (2~hydroxy-3-dimethy.laminopropyl) -lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [7-amino-1- (2-hydroxy-3-dimethyl-aminopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±)-2-[4-Benzyloxy-l-(2-hydroxy-3-dimethylaminopropyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [4-benzyloxy-l- (2-hydroxy-3-dimethylaminopropyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[5-Benzyloxy-l-(2-hydroxy-3-dimfithylaminopropyl)-lH-iri(Jol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [5-benzyloxy-l- (2-hydroxy-3-dimfithylaminopropyl) -lH-iri (Jol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[6-Benzylo>y-l-(2-hydroxy-3-öimethylaminopropy1)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [6-Benzylo> y-l- (2-hydroxy-3-öimethylaminopropy1) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[7-Benzyloxy-1-(2-hydroxy-3-dimethylaminopropy1)-IH-indol-3-yl ] -3 ·· (lH-indol-3-yl) -maleinimid;(±) -2- [7-Benzyloxy-1- (2-hydroxy-3-dimethylaminopropyl) -IH-indol-3-yl] -3 ·· (1H-indol-3-yl) -maleimide;

(±)-2-[4-Brom-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol~3-yl)-maleinimid;(±) -2- [4-bromo-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol ~ 3-yl) maleimide;

(±)-2-[5-Brom-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [5-bromo-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[6-Brom-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [6-bromo-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[7-Brom-l-(2-hydroxy-3-dimethylarainopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [7-bromo-l- (2-hydroxy-3-dimethylarainopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[4-Chlor-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [4-chloro-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±) -2-[5-Chlor-l- (2-hydroxy-3-dimethylaiiiinopropyl) -lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [5-chloro-1- (2-hydroxy-3-dimethyl-niacinopropyl)-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±)-2-[6-Chlor-l-(2-hydroxy-3-diiaethylaminopropyl) -lh-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [6-chloro-1- (2-hydroxy-3-di-ethylaminopropyl) -l-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±)-2-[7-Chlor-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [7-chloro-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[4-Fluor-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-' yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [4-fluoro-1- (2-hydroxy-3-dimethylaminopropyl) -1H-indol-3'-yl] -3- (1H-indol-3-yl) -maleimide;

(±)-2-[5-Fluor-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [5-fluoro-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[6-Fluor-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [6-fluoro-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-t7-Fluor-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2-t7-fluoro-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[4-Hydroxy-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [4-hydroxy-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[5-Hydroxy-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [5-hydroxy-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[6-Hydroxy-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [6-hydroxy-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[7-Hydroxy-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [7-hydroxy-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[4-Trifluormethyl-l-(2-hydroxy-3-dimethylaminopropyl)-IH-indol~3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [4-trifluoromethyl-l- (2-hydroxy-3-dimethylaminopropyl) -IH-indol ~ 3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[5-^r.rifluormethyl-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [5- ^r- trifluoromethyl-1- (2-hydroxy-3-dimethylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±)-2-[6-Trifluormethyl-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [6-trifluoromethyl-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[7-Trifluormethyl-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(±) -2- [7-trifluoromethyl-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

(±)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-4-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3-dimethylaminopropyl) -4-methoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-5-methoxy-iH-indol-3.-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3-dimethylaminopropyl) -5-methoxy-iH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±) -2-[l-( 2-Hydroxy-3-dimethy Il aminopropyl)-6-methoxy-lH-indol-3-yl]-3-(11;-indol-3-yl)-maleinimid;(±) -2- [1- (2-Hydroxy-3-dimethyl-2-aminopropyl) -6-methoxy-1H-indol-3-yl] -3- (11; -indol-3-yl) -maleimide;

(±)-2-[1-(2-Hydro:cy-3-dimethylaminopropyl)-7-methoxy-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(±) -2- [1- (2-Hydro: cy-3-dimethylaminopropyl) -7-methoxy-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

(±)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-4,5-methylendioxylH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3-dimethylaminopropyl) -4,5-methylendioxylH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-5,6-methylendioxylH-indol-3-yl]-3-(lH-indol-3-yl)-maieinimid;(±) -2- [l- (2-hydroxy-3-dimethylaminopropyl) -5,6-methylendioxylH-indol-3-yl] -3- (lH-indol-3-yl) -maieinimid;

(±)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-6,7-methylendioxylH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3-dimethylaminopropyl) -6,7-methylendioxylH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)~4-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3-dimethylaminopropyl) ~ 4-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(2--Hydroxy-3-dimethylaminopropyl)-5-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2 - hydroxy-3-dimethylaminopropyl) -5-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-6-methyl-.lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3-dimethylaminopropyl) -6-methyl-.lh-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-7-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3-dimethylaminopropyl) -7-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-4-nitro-iH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3-dimethylaminopropyl) -4-nitro-IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(2-Hydroxy-3-dimethylaminopropyi)-5-nitro-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3-dimethylaminopropyi) -5-nitro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-ö-nitro-lH-indol-S-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3-dimethylaminopropyl) -o-nitro-lH-indol-S-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-7-nitro-lH-indol-3-•y 1 ] -3- (lH-indol-3-yl) -maleinimid;(±) -2- [1- (2-hydroxy-3-dimethylaminopropyl) -7-nitro-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-4-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3-dimethylaminopropyl) -4-methylthio-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±) -2-[l-(2-Hydroxy-3-dimethylaminopropyl)-5-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [1- (2-hydroxy-3-dimethylaminopropyl) -5-methylthio-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±) -2-[l-(2-Hydroxy-3-dimethylaminopropy?.)-6-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid: (±) -2- [1- (2-Hydroxy-3-dimethylaminopropyl) -6-methylthio-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide :

(±)-2-[1-(2-Hydroxy-3-dimethylaminopropyl)-7-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [1- (2-hydroxy-3-dimethylaminopropyl) -7-methylthio-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[1-(2-Hydroxy-3-dimethylaminopropyl)-4,5-dimethoxy-lH indöi-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [1- (2-hydroxy-3-dimethylaminopropyl) -4,5-dimethoxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-5,6-dimethoxy-lH indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [1- (2-hydroxy-3-dimethylaminopropyl) -5,6-dimethoxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±)-2-[1-(2-Hydroxy-3-dimethylaminopropyl)-6,7-dimethoxy-lH indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [1- (2-hydroxy-3-dimethylaminopropyl) -6,7-dimethoxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[4-Acetylamino-l-(2-hydroxy-3-dimethylaminopropyl)-lH indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [4-Acetylamino-1- (2-hydroxy-3-dimethylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[5-Acetylamino-l-(2-hydroxy-3-dimethylaminopropyl)-lH indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [5-Acetylamino-1- (2-hydroxy-3-dimethylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[6-Acetylamino-l-(2-hydroxy-3-dimethylaminopropyl)-lH indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [6-Acetylamino-1- (2-hydroxy-3-dimethylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

-2-[7-Acetylamino-l-(2-hydroxy-3-dimethylaminopropyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;-2- [7-acetylamino-l- (2-hydroxy-3-dimethylaminopropyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[4-Amino-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [4-amino-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[5-Amino-l-(2-hydroxy-3-dimethylaminopropyl)-iH-indoi-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [5-amino-l- (2-hydroxy-3-dimethylaminopropyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+) -2-[6-Aiiino-l-(2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(+) -2- [6-Ailino-1- (2-hydroxy-3-dimethylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[7-Amino-l-(2-hydroxy-3-dimethylaminopropyl)~lH-inaol-3· yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [7-amino-1- (2-hydroxy-3-dimethylaminopropyl) -1H-inaol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[4-Benzyloxy-l-(2-hydroxy-3-dimethylaminopropyl)-IH-indol-3-yl]-3-v'lH-indol-3-yl}-maleinimid;(+) - 2- [4-benzyloxy-l- (2-hydroxy-3-dimethylaminopropyl) -IH-indol-3-yl] -3-v'lH-indol-3-yl} -maleimide;

(+)-2-[5-Benzyloxy-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [5-benzyloxy-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[6-Benzyloxy-l-(2-hydroxy-3-dimethylaminopropyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [6-benzyloxy-l- (2-hydroxy-3-dimethylaminopropyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

( + )-2-[7~Benzyloxy-l-(2-hydroxy-3-dimethylaminopropyl)-3.H-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) -2- [7-benzyloxy-1- (2-hydroxy-3-dimethylaminopropyl) -3H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[4-Brom-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [4-bromo-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+) -2-[5-Brom-l-(2-hydroxy-3-dimethylaminopropyl) -lii-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) -2- [5-bromo-1- (2-hydroxy-3-dimethylaminopropyl) -li-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[6-Brom-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [6-bromo-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[7-Brom-l-(2-hydroxy-J-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [7-bromo-l- (2-hydroxy-J-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

-68--68-

(+)-2-[4-Chlor-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [4-chloro-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[5-Chlor-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [5-chloro-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[6-Chlor-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [6-chloro-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[7-Chlor-l-(2-hydroxy-3-dimethylaminopropy\)-lH-indoi-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [7-chloro-l- (2-hydroxy-3-dimethylaminopropyl \) - lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[4-Fluor-l~(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indoi-3-yl)-maleinimid;(+) - 2- [4-fluoro-l ~ (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[5-Fluor-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [5-fluoro-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[6-Fluor-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indoi-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [6-fluoro-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[7-Fluor-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-naleinimid;(+) - 2- [7-fluoro-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) -naleinimid;

(+)-2-[4-Hydroxy-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [4-hydroxy-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[5-Hydroxy-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [5-hydroxy-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[6-Hydroxy-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [6-hydroxy-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[7-Hydroxy-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [7-hydroxy-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[4-Trifluormethyl-l-(2-hydroxy-3-dimethylaminopropyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [4-trifluoromethyl-l- (2-hydroxy-3-dimethylaminopropyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

-89--89-

(+)-2-[5-Trifluormethyl-l-(2-hydroxy-3-dimetbyla!ninopropyl)-lH indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [5-trifluoromethyl-1- (2-hydroxy-3-dimetylborinopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

-2 ·.ι *rifluorm(2thyl-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2-fluoro (2-ethyl-1- (2-hydroxy-3-dimethylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[7-Trifluormethyl-l-(2-hydroxy-3-dimethylaminopropyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [7-trifluoromethyl-l- (2-hydroxy-3-dimethylaminopropyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-4-methoxy-lH-indol-3-yl]-3~(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3-dimethylaminopropyl) -4-methoxy-lH-indol-3-yl] -3 ~ (lH-indol-3-yl) maleimide;

(+)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-5-methoxy-lH-indol-3-yl]-3-(lH-indoi-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3-dimethylaminopropyl) -5-methoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-6-Tiethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3-dimethylaminopropyl) -6-Tiethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-7-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3-dimethylaminopropyl) -7-methoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(2-Hydroxy-3-dimsthylaminopropyl)-4,5-methylendioxylH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3-dimsthylaminopropyl) -4,5-methylendioxylH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-5,6-methylendioxy lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;-2- [1- (2-hydroxy-3-dimethylaminopropyl) -5,6-methylenedioxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

-2-[l-(2-Hydroxy-3-dimfjthylaminopropyl)-6_/7-methylendioxylH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;-2- [1- (2-hydroxy-3-dimphthylaminopropyl) -6 _/ 7-methylenedioxyH-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-4-methyl-lH-indol-3 yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [1- (2-hydroxy-3-dimethylaminopropyl) -4-methyl-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[l-(2-Hydroxy-3-diiethylaminopropyl)-S yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [1- (2-hydroxy-3-diiethylaminopropyl) -Sily] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[l-(2-Hydroxy-3-dimethylamihopropyl)-e yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [1- (2-hydroxy-3-dimethylami-propyl) -e-yl] -3- (1H-indol-3-yl) -maleimide;

-90--90-

(+)-2-[l-(2-Hydroxy-3-dimethylaninopropyl)-7-^inethyl-iH-indol-3-yl]-3-(lH-indol-3-yl)-raaleinimid;(+) - 2- [l- (2-hydroxy-3-dimethylaninopropyl) -7- ^ inethyl-IH-indol-3-yl] -3- (lH-indol-3-yl) -raaleinimid;

(-i-)-2-[l-(2-Hydroxy-3-diinethylaminopropyl)-4-nitro-lH-indol-3-(-I -) - 2- [l- (2-hydroxy-3-diinethylaminopropyl) -4-nitro-lH-indol-3-

( + ) -2-[l-(2-Hydroxy-3-dimethylaiainopropyl)-5-nitro-llv-indol-3 yl]-3-(lH-indol-3-yl)-maleinimid;(+) -2- [1- (2-hydroxy-3-dimethylaiopropyl) -5-nitro-llv-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-6-nitro-iH-indol-3 yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [1- (2-hydroxy-3-dimethylaminopropyl) -6-nitro-iH-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-V-nitro-lH-indol-S yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [1- (2-hydroxy-3-dimethylaminopropyl) -V-nitro-1H-indol-5-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-4-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleiniinid;(+) - 2- [l- (2-hydroxy-3-dimethylaminopropyl) -4-methylthio-lH-indol-3-yl] -3- (lH-indol-3-yl) -maleiniinid;

(+)-2-[1-(2-Hydroxy-3-dimethylaminopropyl)-5-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [1- (2-hydroxy-3-dimethylaminopropyl) -5-methylthio-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

( + )-2-[l-(2-Hyd?;oxy-3-dimethylaminopropyl)-6-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) -2- [1- (2-hydroxy-3-dimethylaminopropyl) -6-methylthio-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-7-methylthio-lH-indol-3-yl]-3-(lK-indol-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3-dimethylaminopropyl) -7-methylthio-lH-indol-3-yl] -3- (lK-indol-3-yl) maleimide;

(+)-2-[ J.-(2-Hydroxy-3-dimethylaminopropyl) -4,5-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [J .- (2-hydroxy-3-dimethylaminopropyl) -4,5-dimethoxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[1-(2-Hydroxy-3-dimethylaminopropy])-5,6-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [1- (2-hydroxy-3-dimethylaminopropyl]) - 5,6-dimethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-6,7-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3-dimethylaminopropyl) -6,7-dimethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-) -2- [ 4-Acetylamino-1- (2-hydroxy-.?-dimethylaminopropy 1) -IH-indol-3-yl]-3-(lH-indol--3-yl)-inalei.nim;.c\;(-) -2- [4-Acetylamino-1- (2-hydroxy-.dimethyl-amino-propyl-1) -IH-indol-3-yl] -3- (1H-indol-3-yl) -incalene.nim ; .c \;

-91--91-

(-)-2-[5-Acetylamino-l-(2-hyclroxy-3-dimcthyla:nincpropyi)-lH·- indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [5-Acetylamino-1- (2-hydroxyxy-3-dimethyl-2-naphthyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(-)-2-[6-Acetylamino-l-(2-hydroxy-3-dimethylaminopropyl)-λΗ-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [6-acetylamino-l- (2-hydroxy-3-dimethylaminopropyl) -λΗ-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[7-Acetylamino-l-(2-hydroxy-3-dimethylaminopropyl)-IH-.indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;maleimide 2- [7-acetylamino-l- (2-hydroxy-3-dimethylaminopropyl) -IH-.indol-3-yl] -3- (lH-indol-3-yl) - (-);

(-)-2-[4-Amino-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yi]-3-(IH-indol-3-yl)-maleinimid;(-) - 2- [4-amino-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

(-)-2-[5-Amino-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [5-amino-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[6-Amino-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [6-amino-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-) -2-[7-Amino-l- (2-hydroxy-3-dimethylaminopropyl) -lH--indol-3-(-) -2- [7-Amino-1- (2-hydroxy-3-dimethylaminopropyl) -LH-indole-3-one

(-)-2-[4-Benzyloxy-l-(2-hydroxy-3-dimethylaminopropyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [4-benzyloxy-l- (2-hydroxy-3-dimethylaminopropyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[5-Benzyloxy-l-(2-hydroxy-3-dimethylaminopropyl)-lH~ indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [5-Benzyloxy-1- (2-hydroxy-3-dimethylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(-)-2-[6-Benzyloxy-l-(2-hydroxy-3-dimethylaminopropyI)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [6-benzyloxy-l- (2-hydroxy-3-dimethylaminopropyI) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[7-Benzyloxy-l-(2-hydroxy-3-dimethylaminopropyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;maleimide 2- [7-benzyloxy-l- (2-hydroxy-3-dimethylaminopropyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) - (-);

(-)-2-[4-Brom-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3 yl]-3-(lH-indol~3-yl)-maleinimid?(-) - 2- [4-Bromo-1- (2-hydroxy-3-dimethylaminopropyl) -1H-indol-3-yl] -3- (1H-indole-3-yl) -maleimide?

(-)-2-[5-Brom-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3 yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [5-Bromo-1- (2-hydroxy-3-dimethylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

-92--92-

yl]-3-(lH-indol-3-yl)-maleinimid;maleimide yl] -3- (lH-indol-3-yl);

(-)-2-17-Brom-1-(2-hydroxy-3-dimethylaminopropy1)-IH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(-) - 2-17-bromo-1- (2-hydroxy-3-dimethylaminopropy1) -IH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

(-)-2-[4-Chlor-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-.yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [4-chloro-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-.yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[5-Chlor-l-(2-hydroxy-3-dimethylaminopropyl)-iH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [5-chloro-l- (2-hydroxy-3-dimethylaminopropyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[6-Chlor-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [6-chloro-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[7-Chlor-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [7-chloro-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[4-Fluor-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [4-fluoro-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[5-Fluor-l-(2-hydroxy-3-dimethyiaminopropyi)-lH-indol-3-yl ] -3- (lH-indwj.-3-yl) -maleinimid;(-) - 2- [5-Fluoro-1- (2-hydroxy-3-dimethylaminopropyl) -1H-indol-3-yl] -3- (1H-indwj.-3-yl) -maleimide;

(-)-2-[6-Fluor-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [6-fluoro-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[7-Fluor-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [7-fluoro-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[4-Hydroxy-l-(2-hydroxy-3-dimethylaminopropyl)-IH-indol 3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [4-Hydroxy-1- (2-hydroxy-3-dimethylaminopropyl) -IH-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(-)-2-[5-Hydroxy-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [5-hydroxy-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[6-Hydroxy-l-(2-hydroxy-3-dimethylatt'inopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [6-hydroxy-l- (2-hydroxy-3-dimethylatt'inopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

-93--93-

(-)-2-[7-Hydroxy-l-(2-hydroxy~3-aimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [7-hydroxy-l- (2-hydroxy ~ 3-aimethylaminopropyl) -lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

(-) —2-[4 i.¹rifluormethyl-l-(2-hydroxy-3-dimethylaminopropyl) -IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) -2- [4 i. ¹ rifluoromethyl-1- (2-hydroxy-3-dimethylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(-)-2-[5-Trifluormethyl-1-(2-hydroxy-3-dimethylaminopropyl)-IH-. indol-3-yl ] -3- (lH-indol-3-yl) -maleiniinid;(-) - 2- [5-trifluoromethyl-1- (2-hydroxy-3-dimethylaminopropyl) -IH-. indol-3-yl] -3- (1H-indol-3-yl) -maleinidine;

(")-2-[6-Trifluormethy1-1-(2-hydroxy-3-dimethylaminopropyl)-IH-mdol-3-yl]-3-(lH-indol-3-yl)-maleinimid;( "S) -2- [6-Trifluormethy1-1- (2-hydroxy-3-dimethylaminopropyl) -IH-mdol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[7-Trifluormethyl-l-(2-hydroxy-3-dimethylaminopropyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;maleimide 2- [7-trifluoromethyl-l- (2-hydroxy-3-dimethylaminopropyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) - (-);

(-)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-4-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(2-hydroxy-3-dimethylaminopropyl) l- -4-methoxy-lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

(-)-2-[1-(2-Hydroxy-3-dimethylaminopropyl)-5-methoxy-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [1- (2-hydroxy-3-dimethylaminopropyl) -5-methoxy-IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(~)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-6-methoxy-lH"indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(~) -2- [l- (2-hydroxy-3-dimethylaminopropyl) -6-methoxy-lH 'indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[l-(2-Hydroxy-3-dimethylaminopropyi)-7-methox3^-lH~indol-3-y.l]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [l- (2-hydroxy-3-dimethylaminopropyi) -7-methox3 ^ -lH ~ indol-3-y.l] -3- (lH-indol-3-yl) maleimide;

(-)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-4,5-methylendioxylH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(2-hydroxy-3-dimethylaminopropyl) -4,5-l- methylendioxylH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

(-)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-5,6-methylendioxylH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(2-hydroxy-3-dimethylaminopropyl) -5,6-l- methylendioxylH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

(-)-2-[1-(2-Hydroxy-3-dimethylaminopropyl)-6,7-methylendioxylH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [1- (2-hydroxy-3-dimethylaminopropyl) -6,7-methylendioxylH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

(-)-2-tl-(2-Hydroxy-3-dimethylaminopropyl)-4-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2-tl (2-hydroxy-3-dimethylaminopropyl) -4-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[l-(2-Hydroxy-3-dimethyian!inopropyl)-5-inethyl-lH-ir;dol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [l- (2-hydroxy-3-dimethyian inopropyl!) -5-inethyl-lH-ir; dol-3-yl] -3- (lH-indol-3-yl) maleimide;

( •)-2-[l-(2-Hydroxy-3-dimethylaminopropyl) -e-methyl-lH-indol-O-yl]-3-(lH-indol-3-yl)-maleinimid;(•) -2- [1- (2-hydroxy-3-dimethylaminopropyl) -e-methyl-1H-indol-O-yl] -3- (1H-indol-3-yl) -maleimide;

(-)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-V-. yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [l- (2-hydroxy-3-dimethylaminopropyl) -V-. maleimide yl] -3- (lH-indol-3-yl);

(-)-2-[l-(2--Hydroxy-3-dimethylaminopropyl)-4-nitro-lH-indol-3 yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [1- (2-Hydroxy-3-dimethylaminopropyl) -4-nitro-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(-)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-5-nitro-lH-indol-3 yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [1- (2-Hydroxy-3-dimethylaminopropyl) -5-nitro-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(-)-2-[l-(2-Hydroxy-3-dimethylaminopropy1)-6-nitro-lH-indol-3 3-(lH indol-3-yl)-maleinimid;(-) - 2- [1- (2-Hydroxy-3-dimethylaminopropyl) -6-nitro-1H-indol-3 3- (1H-indol-3-yl) -maleimide;

(-)-2-[1-(2-Hydroxy-3-dimethylaminopropy1)-7-nitro-lH-indol-3 yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [1- (2-Hydroxy-3-dimethylaminopropyl) -7-nitro-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(-) -2-[l-(2-Hydroxy-3-dimethylamir:opropyl)-4-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) -2- [1- (2-Hydroxy-3-dimethylamino-propyl) -4-methylthio-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(-)-2-[1-(2-Hydroxy-3-dimethylaminopropyl)-5-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [1- (2-hydroxy-3-dimethylaminopropyl) -5-methylthio-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-6-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(2-hydroxy-3-dimethylaminopropyl) l- -6-methylthio-lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

(-)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-7-methylthio-lH-indol-3-yl]-3-^lH-indol-3-yl)-maleinimid;(-) - 2- [(2-hydroxy-3-dimethylaminopropyl) l- -7-methylthio-lH-indol-3-yl] -3- maleimide ^ lH-indol-3-yl);

(-)-2-[l-(2-Hydroxy-3-dimethylaminopropy1)-4,5-dimethoxy-lH-indol-3-yl]-3-(lK-indol-3-yl)-maleinimid;(-) - 2- [(2-hydroxy-3-dimethylaminopropy1) -4,5-dimethoxy-l-lH-indol-3-yl] -maleimide -3- (lK-indol-3-yl);

(-)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-5,6-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [(2-hydroxy-3-dimethylaminopropyl) -5,6-dimethoxy-l-lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

(-)-2-[l-(2-Hydroxy-3-dimethyiaxinopropyl)-6,7-dimethoxy-lH-indol-3 -yl] -3-(lH-indol-3-yl)-maleinimid;(-) - 2- [1- (2-Hydroxy-3-dimethyiaxinopropyl) -6,7-dimethoxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±)-.?-[4-Acetylamino-.l-(2-hydroxy-3-(4-morpholino) propyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -β- [4-Acetylamino-1- (2-hydroxy-3- (4-morpholino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) maleimide;

(±)-2-[5-Acetylamino-l-(2-hydroxy-3-(4-morpholino)propyl)-IH-•indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [5-acetylamino-l- (2-hydroxy-3- (4-morpholino) propyl) -IH- • indol-3-yl] -3- (lH-indol-3-yl) - maleimide;

(±)-2-[6-Acetylamino-l-(?-hydroxy-3~(4-morpholino)propyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [6-acetylamino-l - (? - hydroxy-3 ~ (4-morpholino) propyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[7-Acetylamino-l-(2-hydroxy-3-(4-morpholino)propyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [7-acetylamino-l- (2-hydroxy-3- (4-morpholino) propyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[4-Amino-1-(2-hydroxy-J-(4-morpholino)propyl)-IH-indol-3 yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [4-Amino-1- (2-hydroxy-J- (4-morpholino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±)-2-[5-Amino-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3· yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [5-Amino-1- (2-hydroxy-3- (4-morpholino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide ;

(±)-2-[6-Amino-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [6-amino-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[7-Amino-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [7-amino-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[4-Benzyloxy-l-(2-hydroxy-3-(4-morpholino)propyl)-IH-indol-3-yl]-3-(lH-Jndol-3-yl)-maleinimid;(±) -2- [4-benzyloxy-l- (2-hydroxy-3- (4-morpholino) propyl) -IH-indol-3-yl] -3- (lH-Jndol-3-yl) maleimide ;

(±)-2-[5-Benzyloxy~l-(2-hydroxy-3-(4-morpholino)propyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [5-benzyloxy ~ l- (2-hydroxy-3- (4-morpholino) propyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[6-Benzyloxy-l-(2-hydroxy-3-(4-morpholino)propyl)-IH-indol-3~yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [6-benzyloxy-l- (2-hydroxy-3- (4-morpholino) propyl) -IH-indol-3 ~ yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[7-Benzyloxy-l-(2-hydroxy-3-(4—morpholino)propyl)-IH-indol-3 -yl ] -3 -.(lH-indol-3 -yl) -maleinimid;(±) -2- [7-Benzyloxy-1- (2-hydroxy-3- (4-morpholino) propyl) -1H-indol-3-yl] -3 -. (1H-indol-3-yl) - maleimide;

(±)-2-[4-Brom-l-(2-hydroxy-J-{'»-inorphoiino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [4-bromo-l- (2-hydroxy-J - { ' "- inorphoiino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) - maleimide;

(±)-2-[5-Brom-l-(2-hydroxy-3-(4-morpholino)propyl)--lH-indol-3-yl] -3- (lH-indo.l-3-yl) -maleinimid;(±) -2- [5-Bromo-1- (2-hydroxy-3- (4-morpholino) propyl) -1H-indol-3-yl] -3- (1H-indo-1,3-yl ) -maleimide;

( + )-2-[6-Brom--l-(2-hydroxy-3-(4-F.orpholino)propyl)-iH-indol-3-yl]-3-(lH--indol-3-yl)-maleinimici;(+) -2- [6-Bromo-1- (2-hydroxy-3- (4-fluorophino) propyl) -iH-indol-3-yl] -3- (1H-indole-3-yl) yl) -maleinimici;

(±)-2~[7-Brom-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2 ~ [7-bromo-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[4-Chlor-1-(2-hydroxy-3-(4-morpholino)propy1)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [4-chloro-1- (2-hydroxy-3- (4-morpholino) propy1) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[5-Chlor-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [5-chloro-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[6-Chlor-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [6-chloro-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[7-Chlor-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [7-chloro-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[4-Fluor-1-(2-hydroxy-3-(4-morpholino)propy1)-lH-indol-3 yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [4-Fluoro-1- (2-hydroxy-3- (4-morpholino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±)-2-[5-Fluor-l-(2-Hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [5-fluoro-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[6-Fluor-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimii ?(±) -2- [6-fluoro-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) -maleinimii ?

(±)-2--[7-Fluor-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl ] -3-· (lH-indol-3-yl) -maleinimid ;(±) -2 - [7-Fluoro-1- (2-hydroxy-3- (4-morpholino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) maleimide;

(±)-2-[4-Hydroxy-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-νlH-indol-3-yl)-maleinimid;(±) -2- [4-hydroxy-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3-νlH-indol-3-yl) maleimide;

(±)-2-[5-Hydroxy-l-(2-hydroxy-3- (4-morpholinc)prcpyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [5-Hydroxy-1- (2-hydroxy-3- (4-morpholino) propropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide ;

(±)-2-[6-Hydroxy-l-(2-hydroxy-3-(4-morpholino)propyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [6-hydroxy-l- (2-hydroxy-3- (4-morpholino) propyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[7--Hydroxy-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl) -maleinimid; ,(±) -2- [7-Hydroxy-1- (2-hydroxy-3- (4-morpholino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) - maleimide; .

(±)-2-[4-Trifluormethyl-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [4-trifluoromethyl-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[5-Trifluormethyl-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [5-trifluoromethyl-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[6-Trifluormethyl-l-(2-hydrox.y-3-(4-morpholino) propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [6-Trifluoromethyl-1- (2-hydroxy-3- (4-morpholino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) maleimide;

(±)-2-[7-Trifluormethyl-l-(2-Hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [7-trifluoromethyl-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-4-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3- (4-morpholino) propyl) -4-methoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[l-{2-IIydroxy-3-(4-morpholino) propyl)-5-methoxy-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(±) -2- [1- {2-Hydroxy-3- (4-morpholino) propyl) -5-methoxy-1H-indol-3-yl] -3- (IH-indol-3-yl) -maleimide ;

(±)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-6-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3- (4-morpholino) propyl) -6-methoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[1-(2-Hydroxy-3-(4-morpholino)propyl)-7-methoxy-lK-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [1- (2-hydroxy-3- (4-morpholino) propyl) -7-methoxy-lK-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-4,5-methylendioxylH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3- (4-morpholino) propyl) -4,5-methylendioxylH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-5,6-methylendioxylH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3- (4-morpholino) propyl) -5,6-methylendioxylH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

-98- , ;-98-,;

< I<I

(±)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-6,7-methylendioxylH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3- (4-morpholino) propyl) -6,7-methylendioxylH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-4-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3- (4-morpholino) propyl) -4-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-5-methyl-lH-indol-. 3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3- (4-morpholino) propyl) -5-methyl-lH-indole. 3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-6-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3- (4-morpholino) propyl) -6-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-7-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3- (4-morpholino) propyl) -7-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-4-nitro-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3- (4-morpholino) propyl) -4-nitro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-S-nitro-lH-indol-S-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3- (4-morpholino) propyl) -S-nitro-lH-indol-S-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-6-nitro-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3- (4-morpholino) propyl) -6-nitro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-T-nitro-lH-indol-S-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3- (4-morpholino) propyl) -T-nitro-lH-indol-S-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-4-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3- (4-morpholino) propyl) -4-methylthio-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-5-met'iylthio-lH-indol-3-yl]-3-(lH-indol-J-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3- (4-morpholino) propyl) -5-met'iylthio-lH-indol-3-yl] -3- (lH-indole-J-yl) maleimide;

(±)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-6-methylthio-lH-indol-3-yl]-3-(lH-indoi-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3- (4-morpholino) propyl) -6-methylthio-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-7-methylthio-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3- (4-morpholino) propyl) -7-methylthio-IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

-99« :-99 «:

(±)-2-[l-(2-Hydroxy-3-(4-mornholino)propyl)-4,5-aimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3- (4-mornholino) propyl) -4,5-aimethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-5,6-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3- (4-morpholino) propyl) -5,6-dimethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±) -2- [ 1- (2-Hydroxy-3- (4-morpholine») propyl) -6,7-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [1- (2-Hydroxy-3- (4-morpholino) -propyl) -6,7-dimethoxy-1H-indol-3-yl] -3- (1H-indol-3-yl ) maleimide;

(+)-2-[4"Acetylamino-l-(2-hydroxy-3-(4-morpholino)propyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [4 "acetylamino-l- (2-hydroxy-3- (4-morpholino) propyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

-2-[5-Acetylamino-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;-2- [5-acetylamino-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[6-Acetylamino-1-(2-hydroxy-3-(4-morpholino)propyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid?(+) - 2- [6-acetylamino-1- (2-hydroxy-3- (4-morpholino) propyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ?

(+)-2-[7-Acetylamino-1-(2-hydroxy-3-(4-morpholino)propyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [7-Acetylamino-1- ( 2- hydroxy-3- (4-morpholino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide ;

(+)-2-[4-Amino-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [4-amino-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[5-Amino-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [5-amino-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[6-Amino-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [6-amino-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+) -2-[7-Amino-1-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) -2- [7-Amino-1- (2-hydroxy-3- (4-morpholino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide ;

(+)-2-[4-Benzyloxy-l-(2-hydroxy-3-(4-morpholino)propyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [4-benzyloxy-l- (2-hydroxy-3- (4-morpholino) propyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[5-Benzyloxy-l-(2-hydroxy-3-(4-morpholino)propyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [5-benzyloxy-l- (2-hydroxy-3- (4-morpholino) propyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

-100- ·\ ;-100- · \;

(+)-2-[6-Benzyloxy-1-(2-hydroxy-3-(4-mörpholino)propy1)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [6-benzyloxy-1- (2-hydroxy-3- (4-mörpholino) propy1) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[7-Benzyloxy-l-(2-hydroxy-3-(4-morpholino)propyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [7-benzyloxy-l- (2-hydroxy-3- (4-morpholino) propyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[4-Brom-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3 . yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [4-Bromo-1- (2-hydroxy-3- (4-morpholino) propyl) -1H-indole-3. maleimide yl] -3- (lH-indol-3-yl);

(+)-2-[5-Brom-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3 yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [5-bromo-1- (2-hydroxy-3- (4-morpholino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[6-Brom-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3 yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [6-bromo-1- (2-hydroxy-3- (4-morpholino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

-2-[7-Brom-l-(2-hydroxy-3-(,-morpholino)prcpyl) -·ΐΗ-ϊηαο1-3-yl]-3-(lH-indol-3-yl)-maleinimid;-2- [7-bromo-1- (2-hydroxy-3 - (, - morpholino) -propyl) -. Beta.

(+)-2-[4-Chlor-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [4-chloro-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[5-Chlor-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [5-chloro-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[6-Chlor-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol~3-yl)-maleinimid;(+) - 2- [6-chloro-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol ~ 3-yl) maleimide ;

(+)-2-[7-Chlor-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [7-chloro-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

-2-[4-Fluor-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl) maleinimid;-2- [4-fluoro-1- (2-hydroxy-3- (4-morpholino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) maleimide;

(+)-2-[5-Fluor-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3· yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [5-Fluoro-1- (2-hydroxy-3- (4-morpholino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide ;

(+)-2-[6-Fluor-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [6-fluoro-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

-ιοί- ;-ιοί-;

(+)-2-[7-Fluor-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [7-fluoro-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[4-Hydroxy-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [4-hydroxy-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[5-Hydroxy-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-• 3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [5-Hydroxy-1- (2-hydroxy-3- (4-morpholino) propyl) -1H-indole-3-yl] -3- (1H-indol-3-yl) - maleimide;

(+)-2-[6-Hydroxy-l-(2-hydroxy 3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [6-Hydroxy-1- (2-hydroxy-3- (4-morpholino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[7-Hydroxy-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol--3-yl)-maleinimid;(+) - 2- [7-hydroxy-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol - 3-yl) - maleimide;

-2-[4-Trifluormethyl-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;-2- [4-trifluoromethyl-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[5-Trifluormethyl-1-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [5-trifluoromethyl-1- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[6-Trifluormethyl-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [6-trifluoromethyl-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[7-Trifluormethyl-1-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol~3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [7-Trifluoromethyl-1- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol ~ 3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-4-methoxy-lH-indol-0 3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [1- (2-Hydroxy-3- (4-morpholino) propyl) -4-methoxy-1H-indol-0 3-yl] -3- (1H-indol-3-yl) - maleimide;

(+)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-5-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3- (4-morpholino) propyl) -5-methoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-6-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3- (4-morpholino) propyl) -6-methoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-7-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3- (4-morpholino) propyl) -7-methoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

»102-»102-

( + )-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-4,5-ni«lirhylendioxylH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) -2- [1- (2-Hydroxy-3- (4-morpholino) propyl) -4,5-ni-ethylenedioxylH-indol-3-yl] -3- (1H-indol-3-yl) maleimide;

(+)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-5,6-methylendioxylH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3- (4-morpholino) propyl) -5,6-methylendioxylH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-6,7-methylendioxy-XH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3- (4-morpholino) propyl) -6,7-methylenedioxy-XH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-4-methyl-lH-indol-1>-yl] -3- (lH-indol-3-yl) -maleinimid;(+) - 2- [1- (2-Hydroxy-3- (4-morpholino) propyl) -4-methyl-1H-indol-1> -yl] -3- (1H-indol-3-yl) - maleimide;

(+)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-5-methyl-lH-indol-3-yl]-3-(lH-indoi-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3- (4-morpholino) propyl) -5-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(4)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-6-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(4) -2- [l- (2-hydroxy-3- (4-morpholino) propyl) -6-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-7-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3- (4-morpholino) propyl) -7-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-4-nitro-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3- (4-morpholino) propyl) -4-nitro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-5-nitro-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3- (4-morpholino) propyl) -5-nitro-lH-indol-3-yl] -3- (lH-indol-3yl) maleimide ;

(+)-2-[l-(2-Hydroxy-3-(4-morpholino)propy.l)-6-nitro-lH-indol-3-0 yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [1- (2-Hydroxy-3- (4-morpholino) propyl) -6-nitro-1H-indol-3-O-yl] -3- (1H-indol-3-yl ) maleimide;

(+)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-7-nitro-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3- (4-morpholino) propyl) -7-nitro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-4-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-raaleinimid;(+) - 2- [l- (2-hydroxy-3- (4-morpholino) propyl) -4-methylthio-lH-indol-3-yl] -3- (lH-indol-3-yl) -raaleinimid ;

(+)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-5-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3- (4-morpholino) propyl) -5-methylthio-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

-103- , ;-103-;

-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-6-iuethylthxo-lkindol-3-yl]-3-(IH-indol-3-yl)-maleinimid;-2- [l- (2-hydroxy-3- (4-morpholino) propyl) -6-iuethylthxo-lkindol-3-yl] -3- (IH-indol-3-yl) maleimide;

(+)-2-[1-(2-Hydroxy-3-(4-morpholino)propy1)-7-methylthio-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [1- (2-hydroxy-3- (4-morpholino) propy1) -7-methylthio-IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-4,5-dirnethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3- (4-morpholino) propyl) -4,5-dirnethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)"5,6-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3- (4-morpholino) propyl) "5,6-dimethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[1-(2-Hydroxy-3-(4-morpholino)propy1)-6,7-dimethoxy-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [1- (2-hydroxy-3- (4-morpholino) propy1) -6,7-dimethoxy-IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-) -2- [ 4·-Acetylamino-1- (2-hydroxy-3- (4-morpholino) propy 1) -IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) -2- [4-Acetylamino-1- (2-hydroxy-3- (4-morpholino) propyl] -1H-indol-3-yl] -3- (1H-indol-3-yl) maleimide;

(-)-2-[5-Acetylamino-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [5-Acetylamino-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[6-Acetylamino-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [6-acetylamino-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[7-Acetylamino-l-(2-hydroxy-3-(4-morpholino)propyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [7-acetylamino-l- (2-hydroxy-3- (4-morpholino) propyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[4-Amino-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [4-amino-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[5-Amino-l-(2~hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [5-amino-l- (2 ~ hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[6-Amino-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [6-amino-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[7-Amino-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [7-amino-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

-104- ι-104-

(-)-2-[4-Benzyloxy-l-(2-hydroxy-3-(4-morpholino)propyl)-iH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [4-benzyloxy-l- (2-hydroxy-3- (4-morpholino) propyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-) -2-[5-Benzyloxy-l-(2-hydroxyO-(4-iaorpholino)propyl) -IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) -2- [5-Benzyloxy-1- (2-hydroxy-O- (4-ia-morpholino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(-)-2-[6-Benzyloxy-l-(2-hydroxy-3~(4-mcrpholino)propyl)-IH-' indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [6-Benzyloxy-1- (2-hydroxy-3 - (4-mcrpholino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) - maleimide;

(-)-2-[7-Benzyloxy-l-(2-hydroxy-3-(4-morpholino)propyl)-IH-i idol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [7-Benzyloxy-1- (2-hydroxy-3- (4-morpholino) propyl) -1H-idol-3-yl] -3- (1H-indol-3-yl) - maleimide;

(-)-2-[4-Brora-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [4-Brora-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[5-Brom-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleirämid;(-) - 2- [5-bromo-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) -maleirämid ;

(-)-2-[6-Brom-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(-) - 2- [6-bromo-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide ;

(-)-2-[7-Brom-l-(2-hydroxy-3-(4-morpholino'propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [7-bromo-l- (2-hydroxy-3- (4-morpholino'propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[4-Chlor-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [4-chloro-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[5-Chlor-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [5-chloro-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[6-Chlor-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [6-chloro-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[7-Chlor-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [7-chloro-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[4-Fluor-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(-) - 2- [4-fluoro-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide ;

297920 -105- 297920 -105-

(-) -2-[5-Fluor-l-(2-hydroxy-3-(4-morpholino)propyl)-iK-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) -2- [5-Fluoro-1- (2-hydroxy-3- (4-morpholino) propyl) -ki-indol-3-yl] -3- (1H-indol-3-yl) -maleimide ;

(-)-2-[6-Fluor-l-(2-hydroxy-3-(4-morpholino)propyl)-lH~indol-3-yl]-3-(lH~indol-3-yl)-maleini.aid;(-) - 2- [6-fluoro-l- (2-hydroxy-3- (4-morpholino) propyl) -lH ~ indol-3-yl] -3- (lH ~ indol-3-yl) -maleini .AID;

(-)-2-[7-Fluor-l-(2-hydroxy-3-(4-m.rpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [7-fluoro-l- (2-hydroxy-3- (4-m.rpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(~)-2-[4-Hydroxy -l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl ] -3- (lH-indol-3-γ..) -maleinimid;(~) -2- [4-Hydroxy-1- (2-hydroxy-3- (4-morpholino) propyl) -1H-indol-3-yl] -3- (1H-indole-3-yr ..) maleimide;

( -) -2- [ 5-Hydroxy-1- (2-hydroxy-3- (4-luorpholino) propyl) -IH-indol 3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) -2- [5-Hydroxy-1- (2-hydroxy-3- (4-luoropholino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(-)-2-[6-Hydroxy-l-(2-hydroxy-3-(4-morpholino)propyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid; (-) -2- [6-Hydroxy-1- (2-hydroxy-3- (4-morpholino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide ;

(-)-2-[7-Hydroxy-l-(2-hydroxy-3-(4-Liorpholino) propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid,·(-) - 2- [7-Hydroxy-1- (2-hydroxy-3- (4-liorpholino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide ·

(-)-2-[4-Trifluormethyl-1-(2-hydroxy-3-(4~morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [4-trifluoromethyl-1- (2-hydroxy-3- (4 ~ morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[5-Tri fluormethy1-1-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [5-trifluoromethyl] -1- (2-hydroxy-3- (4-morpholino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) - maleimide;

(-)-2-[6-TrifluorT(nethyl-l-(2-hydroxy-3-(4-morpholino) propyl) lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [6-TrifluoroT (ethyl-1- (2-hydroxy-3- (4-morpholino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) - maleimide;

(-)-2-[7-Trifluormethyl-1-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [7-Trifluoromethyl-1- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl,-4-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [l- (2-hydroxy-3- (4-morpholino) propyl, -4-methoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-5-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [l- (2-hydroxy-3- (4-morpholino) propyl) -5-methoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

297 9?O -106- : : . : 297 9? O -106-::. :

(-) -2-[l-(2-Hydroxy-3-(4-morpholino)propyl) -6-methoxy-lH-indo.l-3-yl]-3-(IH-indol-3-yl)-maleinimid;(-) -2- [1- (2-Hydroxy-3- (4-morpholino) propyl) -6-methoxy-1H-indol-1,3-yl] -3- (1H-indol-3-yl) maleimide;

(-·) -2-[l-(2-Hydroxy-3~(4-morpholino)propyl)-7-methoxy-lH-indol-3-yl]-3-(lH-indoI-3-yl)-maleinimid;(- ·) -2- [1- (2-Hydroxy-3 - (4-morpholino) propyl) -7-methoxy-1H-indol-3-yl] -3- (1H-indol-3-yl) - maleimide;

(-)-2-[l-(2-Hydroxy-3-(4-morpholino)propy.l)-4,5-methylendioxylH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(-) - 2- [l- (2-hydroxy-3- (4-morpholino) propy.l) -4,5-methylendioxylH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

(-)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-5,6-methylendioxylH-indol-3-yl]-3-(lH-indol-3-yl)-maleini-inid;(-) - 2- [l- (2-hydroxy-3- (4-morpholino) propyl) -5,6-methylendioxylH-indol-3-yl] -3- (lH-indol-3-yl) -maleini -inid;

(-)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-6,7-methylendioxylH-indo.\-3-yl1-3-(lH-indol-3-yl) -maleinimid;(-) - 2- [1- (2-Hydroxy-3- (4-morpholino) propyl) -6,7-methylenedioxyH-indo-3-yl1-3- (1H-indol-3-yl) - maleimide;

(-)-2-[l-(2-Hydroxy-3-(4-morpholino)propy1)-4-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [l- (2-hydroxy-3- (4-morpholino) propy1) -4-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[l-(2-Hydroxy-3-(4-morpholino)pxOpyl)-5-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [l- (2-hydroxy-3- (4-morpholino) pxOpyl) -5-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-6-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [l- (2-hydroxy-3- (4-morpholino) propyl) -6-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-7-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [l- (2-hydroxy-3- (4-morpholino) propyl) -7-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[1-(2-Hydroxy-3-(4-morpholino)propy1)-4-nitro-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [1- (2-hydroxy-3- (4-morpholino) propy1) -4-nitro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-5-nitro-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [l- (2-hydroxy-3- (4-morpholino) propyl) -5-nitro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-6-nitro-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [l- (2-hydroxy-3- (4-morpholino) propyl) -6-nitro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-7-nitro-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [l- (2-hydroxy-3- (4-morpholino) propyl) -7-nitro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[l-(2-Hydroxy-3-(4-morphalinc)propyi)-4-methylthio-lH-indol-3-yi]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [l- (2-hydroxy-3- (4-morphalinc) propyl) -4-methylthio-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-5-i ethylthio-lH-inc;ol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [1- (2-Hydroxy-3- (4-morpholino) propyl) -5-i ethylthio-1H-ol; 3-yl] -3- (1H-indol-3-yl ) maleimide;

(· ) ~2-[l-(2-Hydroxy-3-(4-morpholino)propyl) -6-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-iV.a."'.einimid;( - ) - 2- [1- (2-Hydroxy-3- (4-morpholino) propyl) -6-methylthio-1H-indol-3-yl] -3- (1H-indol-3-yl) -vi .a "'einimid..;

(-) -2-[ 1- (2-Hydroxy-3- (4-morpholino) propyl) -7-mp.thylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) -2- [1- (2-Hydroxy-3- (4-morpholino) propyl) -7-methylthio-1H-indol-3-yl] -3- (1H-indol-3-yl) maleimide;

(-)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-4,5-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [l- (2-hydroxy-3- (4-morpholino) propyl) -4,5-dimethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-5,6-diinet.hoxy-lH·- indol-3-yl]-3-(lH-indol-3-yl)-maleiniuid;(-) - 2- [1- (2-Hydroxy-3- (4-morpholino) propyl) -5,6-di-ethoxy-1H-indol-3-yl] -3- (1H-indole-3 -yl) -maleiniuid;

(-)-2-[1-(2-Hydroxy-3-(4-morpholino)propyl)-6,7-dimethoxy-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [1- (2-hydroxy-3- (4-morpholino) propyl) -6,7-dimethoxy-IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±) -2-[4-Acetylamino-l-(2-hydroxy-3-(l-piperidino)propy.l) -IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [4-Acetylamino-1- (2-hydroxy-3- (1-piperidino) propyl] -1H-indol-3-yl] -3- (1H-indol-3-yl) maleimide;

(±)-2-[5-Acetylamino-l-(2-hydroxy-3-(1-piperidino)propyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [5-acetylamino-l- (2-hydroxy-3- (1-piperidino) propyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±) -2-[6-Acei;ylamino-l~(2-hydroxy-3-(1-piperidino)propyl) -IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [6-acylamino-1- (2-hydroxy-3- (1-piperidino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) maleimide;

(±)-2-[7-Acetylamino-l-(2-hydroxy-3-(l-piperidino)propyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [7-acetylamino-l- (2-hydroxy-3- (l-piperidino) propyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[4-Amino-1-(2-hydroxy-3-(1-piperidino)propyl)-lH-indol-3· yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [4-Amino-1- (2-hydroxy-3- (1-piperidino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide ;

(±)-2-[5-Amino-l-(2-hydro)cy-3-( 1-piperidino) propyl)-lH-indol-3· yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [5-Amino-1- (2-hydro) cy-3- (1-piperidino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) maleimide;

-108--108-

(±)-2-[6-Amino-l-(2-hydroxy-3-(l-piperidino)propyl)-iH--indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [6-amino-l- (2-hydroxy-3- (l-piperidino) propyl) -IH - indol-3-yl] -3- (lH-indol-3-yl) - maleimide;

(±)-2-[7-Amino-l-(2-hydroxy-3-(l-pioeridino)propyl)-lH-indol-3-yl]-3"(lH-indol-3-yl)-maleinimid;(±) -2- [7-amino-l- (2-hydroxy-3- (l-pioeridino) propyl) -lH-indol-3-yl] -3 '(lH-indol-3-yl) maleimide ;

(±)-2-[4-Benzyloxy-l-(2-hydroxy-3-(l-piperidino)propyl)-IH-indol-3-yl]-3-(lH-indol-3 -yl)-maleinimid;(±) -2- [4-Benzyloxy-1- (2-hydroxy-3- (1-piperidino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide ;

(±)-2-[5-Benzyloxy-l-(2-hydroxy-3-(!-piperidino)propyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [5-benzyloxy-l- (2-hydroxy-3 - (- piperidino) propyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[6-Benzyloxy-l-(2-hydroxy-3-(l-p.v:erJdino)propyl)-lH-indol-3-yl]-3-(lH-:.ndol-3-yl)-maleinimi.l;(±) -2- [6-benzyloxy-l- (2-hydroxy-3- (lp.v: erJdino) propyl) -lH-indol-3-yl] -3- (lH - :. ndol-3- yl) -maleinimi.l;

(±)-2-[7-Benzyloxy-l-(2-hydroxy~3-(l-pip -idino)propyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [7-Benzyloxy-1- (2-hydroxy-3- (1-pipidino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) maleimide;

(±)-2-[4-Brom-l-(2-hydroxy-3-(l-p-peridi.. j)propyi)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [4-Bromo-1- (2-hydroxy-3- (lp -peridi .. j) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl ) maleimide;

(±)-2-[5-Brom-l-(2-hydroxy-3-(l-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl),-maleinimid ;(±) -2- [5-bromo-l- (2-hydroxy-3- (l-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) - maleimide;

(±)-2-[6-Brom-l--(2-hydroxy-3-(l-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [6-bromo-l - (2-hydroxy-3- (l-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) - maleimide;

(±)-2-[7-Brom-l-(2-hydroxy-3-(1-piperidino)propy1)-lH-indol-3-ylj-3-(lH-indol-3-yl)-maleinimid;(±) -2- [7-bromo-l- (2-hydroxy-3- (1-piperidino) propy1) -lH-indol-3-YLJ-3- (lH-indol-3-yl) maleimide;

(±)-2-[4-Chlor-l-(2-hydroxy-3-(l-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [4-chloro-l- (2-hydroxy-3- (l-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[5-Chlor-l-(2-hydroxy-3-(l-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [5-chloro-l- (2-hydroxy-3- (l-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[6-Chlor-l-(2-hydroxy-3-(l-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [6-chloro-l- (2-hydroxy-3- (l-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-LV-ChIOr-I-(2-hydroxy-3-(l-piperidino)propyl)-iii-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2-LV-chloro-I- (2-hydroxy-3- (l-piperidino) propyl) -III-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[4-Fluor-l-(2-hydroxy-3-(1-piperidino)propyl)-lH-indol-3-yl]-3-(lH-Indol-3-yl)-maleinimid;(±) -2- [4-fluoro-l- (2-hydroxy-3- (1-piperidino) propyl) -lH-indol-3-yl] -3- (lH-Indol-3-yl) maleimide ;

(+)-2-[5-Fluor-l-(2-hydroxy-3-(1-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [5-fluoro-l- (2-hydroxy-3- (1-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±) -2-[6-Fluor-Γ-(.2-hydroxy-3-(1-piperidino)propyl) -lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [6-Fluoro-Γ - (2-hydroxy-3- (1-piperidino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) - maleimide;

(±)-2-[7-Fluor-l-(2-hydroxy-3-(1-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [7-fluoro-l- (2-hydroxy-3- (1-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[4-Hydroxy-l-(2-hydroxy-3-(1-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [4-hydroxy-l- (2-hydroxy-3- (1-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[5-Hydroxy-l-(2-hydroxy-3-(1-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [5-hydroxy-l- (2-hydroxy-3- (1-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[6-Hydroxy-l-(2-hydroxy-3-(l-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-ma]einimid;(±) -2- [6-hydroxy-l- (2-hydroxy-3- (l-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) -ma ] einimid;

(±)-2-[7-Hydroxy-l-(2-hydroxy-3-(1-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [7-hydroxy-l- (2-hydroxy-3- (1-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[4-Trifluormethyl-l-(2-hydroxy-3-(1-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [4-trifluoromethyl-l- (2-hydroxy-3- (1-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[5-Trifluormethyl-l-(2-hydroxy-3-(1-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [5-trifluoromethyl-l- (2-hydroxy-3- (1-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[6-Trifluormethyl-l-(2-hydroxy-3-(l-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [6-trifluoromethyl-l- (2-hydroxy-3- (l-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[7-Trifluormethyl-l-(2-hydroxy-3-(l-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [7-trifluoromethyl-l- (2-hydroxy-3- (l-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

-lio--lio-

(±)-2-[l-(2-Hydroxy-3-( 1-piperidino) propyl)-4-met.hoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [1- (2-Hydroxy-3- (1-piperidino) propyl) -4-methoxy-1H-indol-3-yl] -3- (1H-indol-3-yl) maleimide;

(±)-2-[l-(2-Hydroxy-3-(!-piperidino)propyl)-5-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3 - (- piperidino) propyl) -5-methoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±) -2-[l-(2-Hydroxy-3-(l-piperidino)propyl)-6-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [1- (2-Hydroxy-3- (1-piperidino) propyl) -6-methoxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide ;

(±)-2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-7-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3- (1-piperidino) propyl) -7-methoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-4,5-methylendioxylH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3- (1-piperidino) propyl) -4,5-methylendioxylH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[1-(2-Hydroxy-3-(1-piperidino)propyl)-5,6-methylendioxylH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [1- (2-hydroxy-3- (1-piperidino) propyl) -5,6-methylendioxylH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[1-(2-Hydroxy-3-(1-piperidino)propyl)-6,7-methylendioxylH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid'(±) -2- [1- (2-hydroxy-3- (1-piperidino) propyl) -6,7-methylendioxylH-indol-3-yl] -3- (lH-indol-3-yl) maleimide '

(±)-2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-4-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3- (1-piperidino) propyl) -4-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[l-(2-Hydroxy-3-(l-piperidino)propyl)-5-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3- (l-piperidino) propyl) -5-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-6-methyl-lH-indol-0 3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [1- (2-Hydroxy-3- (1-piperidino) propyl) -6-methyl-1H-indol-0 3-yl] -3- (1H-indol-3-yl) - maleimide;

(±)-2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-7-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3- (1-piperidino) propyl) -7-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[l-(2-Hydroxy-3-(l-piperidino)propyl)-4-nitro-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3- (l-piperidino) propyl) -4-nitro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[l-(2-Hydroxy-3-(l-piperidino)propyl)-5-nitro-lH-indol-3-yl]-3-(3.H-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3- (l-piperidino) propyl) -5-nitro-lH-indol-3-yl] -3- (3.H-indol-3-yl) maleimide;

-iii--iii-

(±)-2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-6-nitro-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3- (1-piperidino) propyl) -6-nitro-IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-7-nitro-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3- (1-piperidino) propyl) -7-nitro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-4-methylthio-lH-' indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [1- (2-Hydroxy-3- (1-piperidino) propyl) -4-methylthio-1H-indol-3-yl] -3- (1H-indol-3-yl) - maleimide;

(±)-2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-5-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3- (1-piperidino) propyl) -5-methylthio-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[1-(2-Hydroxy-3-(1-piperidino)propyl)-6-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [1- (2-hydroxy-3- (1-piperidino) propyl) -6-methylthio-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(±)-2-[l-(2-Hydroxy-3-(l-piperidino)propyl)-7-methylthio-lH-indol-3-yl]-o-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3- (l-piperidino) propyl) -7-methylthio-lH-indol-3-yl] -o- (lH-indol-3-yl) maleimide ;

(±)-2-[1-(2-Hydroxy-3-(1-piperidino)propyl)-4,5-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [1- (2-hydroxy-3- (1-piperidino) propyl) -4,5-dimethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-5,6-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3- (1-piperidino) propyl) -5,6-dimethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-6,7-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3- (1-piperidino) propyl) -6,7-dimethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[4-Acetylamino-l-(2-hydroxy-3-(1-piperidino)propyl)-IH-indol-3-ylj-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [4-acetylamino-l- (2-hydroxy-3- (1-piperidino) propyl) -IH-indol-3-YLJ-3- (lH-indol-3-yl) maleimide;

(+)-2-[5-Acetylamino-l-(2-hydroxy-3-· (1-piperidino)propyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [5-Acetylamino-1- (2-hydroxy-3- (1-piperidino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) - maleimide;

(+)-2-[6-Acetylamino-l-(2-hydroxy-3-(1-piperidino)propyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [6-acetylamino-l- (2-hydroxy-3- (1-piperidino) propyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[7-Acetylamino-l-(2-hydroxy-3-(1-piperidino)propyl)-IH-indol-3-yl]-3"(lH~indol-3-yl)-maleinimid;(+) - 2- [7-acetylamino-l- (2-hydroxy-3- (1-piperidino) propyl) -IH-indol-3-yl] -3 '(lH ~ indol-3-yl) maleimide ;

-112--112-

(+)-2-[4-Amino-1-(2-hydroxy-3-(l-piperidino)propyl)-lri-inaol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [4-amino-1- (2-hydroxy-3- (l-piperidino) propyl) -lri-inaol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[5-Amino-l-(2-hydroxy-3-(1-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [5-amino-l- (2-hydroxy-3- (1-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[6-Amino-l-(2-hydroxy-3-(l-pJperidino)propyl)-lH-indol-3-• yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [6-Amino-1- (2-hydroxy-3- (1- p -peridino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) - maleimide;

(+)"2-[7-Amino-l-(2-hydroxy-3-(l-piperidino)propyl)-lH-indol-3 yl]-3-(lH-indol-3-yl)-maleinimid;(+) "2- [7-Amino-1- (2-hydroxy-3- (1-piperidino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[4-Benzyloxy-l-(2-hydroxy-3-(1-piperidino)propyl)-IH-indol~3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [4-benzyloxy-l- (2-hydroxy-3- (1-piperidino) propyl) -IH-indol ~ 3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[5-Benzyloxy-l-(2-hydroxy-3-(1-piperidino)propyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [5-benzyloxy-l- (2-hydroxy-3- (1-piperidino) propyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[6-Benzyloxy-l-(2-hydroxy-3-(1-piperidino)propyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-inaleinimid;(+) - 2- [6-benzyloxy-l- (2-hydroxy-3- (1-piperidino) propyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) -inaleinimid ;

(+)-2-[7-Benzyloxy-l-(2-hydroxy-3-(l-piperidino)propyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [7-benzyloxy-l- (2-hydroxy-3- (l-piperidino) propyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[4-Brom-l-(2-hydroxy-3-(1-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [4-bromo-l- (2-hydroxy-3- (1-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[5-Brom-l-(2-hydroxy-3-(l-piperidino)propyl)-lH-indol-3-0 yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [5-bromo-1- (2-hydroxy-3- (1-piperidino) propyl) -1H-indol-3-o-yl] -3- (1H-indol-3-yl) - maleimide;

(-:·) -2- [6-Brom-l-( 2-hydroxy-3-( 1-piperidino) propyl )-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-: ·) -2- [6-Bromo-1- (2-hydroxy-3- (1-piperidino ) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) maleimide;

(+)-2-[7-Brom-l-(2-hydroxy-3-(1-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [7-bromo-l- (2-hydroxy-3- (1-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[4-Chlor-l-(2-hydroxy-3-(l-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [4-chloro-l- (2-hydroxy-3- (l-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

-113--113-

(+)-2-[5-Chlor-l-(2-hydroxy-3-(l-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [5-chloro-l- (2-hydroxy-3- (l-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[6-Chlor-l-(2-hydroxy-3-(l-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [6-chloro-l- (2-hydroxy-3- (l-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[7-Chlor-l-(2-hydroxy-3-(l-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid,·(+) - 2- [7-chloro-l- (2-hydroxy-3- (l-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ·

(+)-2-[4-Fluor-l-(2-hydroxy-3-(l-piperidino)propyl)-iH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [4-fluoro-l- (2-hydroxy-3- (l-piperidino) propyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[6-Fluor-l-(2-hydroxy-3-(1-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [6-fluoro-l- (2-hydroxy-3- (1-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-17-Fluor-l-(2-hydroxy-3-(l-piperidino^ propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2-17-Fluoro-1- (2-hydroxy-3- (1-piperidino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[4-Hydroxy-l-(2-hydroxy-3-(l-piperidino)propyl)-lK-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [4-hydroxy-l- (2-hydroxy-3- (l-piperidino) propyl) -LK-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[5-Hydroxy-l-(2-hydroxy-3-(1-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [5-hydroxy-l- (2-hydroxy-3- (1-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[6-Hydroxy-l-(2-hydroxy-3-(1-piperidino)propyl)-lH-indol-0 3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [6-Hydroxy-1- (2-hydroxy-3- (1-piperidino) propyl) -1H-indol-0 3-yl] -3- (1H-indol-3-yl) - maleimide;

(+)-2-[7-Hydroxy-l-(2-hydroxy-3-(1-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [7-hydroxy-l- (2-hydroxy-3- (1-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

-2-[4-Trifluormethyl-l-(2-hydroxy-3-(l-piperidino)propyl) lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;-2- [4-trifluoromethyl-1- (2-hydroxy-3- (1-piperidino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

5 (+)-2-[5-Trifluormethyl-1-(2-hydroxy-3-(1-piperidino)propyl) lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;5 (+) - 2- [5-Trifluoromethyl-1- (2-hydroxy-3- (1-piperidino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide ;

( + )-2-16-Trifluormethyl-1-(2-hydroxy-3-(1-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) -2-16-Trifluoromethyl-1- (2-hydroxy-3- (1-piperidino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[7-Trifluornethyl-l-(2-hydroxy-3-(1-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [7-Trifluornethyl-l- (2-hydroxy-3- (1-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[l-(2-Hydroxy-3-(l-piperidino)propyl)-4-methoxy-lH-indol-•3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3- (l-piperidino) propyl) -4-methoxy-lH-indole • 3-yl] -3- (lH-indol-3-yl) - maleimide;

(+)-2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-5-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3- (1-piperidino) propyl) -5-methoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-6-methoxy-lH-indol· 3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [1- (2-Hydroxy-3- (1-piperidino) propyl) -6-methoxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide ;

(+)-2-[1-(2-Hydroxy-3-(1-piperidino)propyl)-7-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [1- (2-hydroxy-3- (1-piperidino) propyl) -7-methoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-4,5-methylendioxylH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3- (1-piperidino) propyl) -4,5-methylendioxylH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[l-(2-Hydroxy-3-(l-piperidino)propyl)-5,6-methylendioxylH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3- (l-piperidino) propyl) -5,6-methylendioxylH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-6,7-methylendioxylH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3- (1-piperidino) propyl) -6,7-methylendioxylH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[1-(2-Hydioxy-3-(1-piperidino)propyl)-4-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [1- (2-Hydioxy-3- (1-piperidino) propyl) -4-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[1··(2-Hydroxy-3-(1-piperidino)propyl)-5-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [1 ·· (2-hydroxy-3- (1-piperidino) propyl) -5-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) - maleimide;

(+)-2-[l-(2-Hydroxy-3-(l-piperidino)propyl)-6-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3- (l-piperidino) propyl) -6-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[1-(2-Hydroxy-3-(1-piperidino)propyl)-7-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [1- (2-hydroxy-3- (1-piperidino) propyl) -7-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

-ns- ,-ns-,

(+)-2-[l-(2-Hydroxy-3-(l-piperidino)propyl)-4-nitro-iH-indol-3-yl]-3-(lH-indol-3-y.l) -maleinimid;(+) - 2- [1- (2-Hydroxy-3- (1-piperidino) propyl) -4-nitro-iH-indol-3-yl] -3- (1H-indol-3-yl) -maleimide ;

(+)-2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-S-nitro-lH-indol-S-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3- (1-piperidino) propyl) -S-nitro-lH-indol-S-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[l-(2-Hydroxy-3-(l-piperidim)propyl)-ö-nitro-lH-indol^· y.l]-3-(lH-indol-3-yl) -maleinimid;(+) - 2- [1- (2-Hydroxy-3- (1-piperidino) propyl) -ö-nitro-1H-indol-1-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-7-nitro-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3- (1-piperidino) propyl) -7-nitro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-4-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3- (1-piperidino) propyl) -4-methylthio-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(+)-2-[1-(2-Hydroxy-3-(1-piperiaino)propyl)-5-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [1- (2-hydroxy-3- (1-piperiaino) propyl) -5-methylthio-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(.+ ) -2- [ 1- (2-Hydroxy-3- (1-piperidino) propyl) -6-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(. + -) -2- [1- (2-Hydroxy-3- (1-piperidino) propyl) -6-methylthio-1H-indol-3-yl] -3- (1H-indol-3-yl) - maleimide;

(+)-2~[l-(2-Hydroxy-3-(1-piperidino)propyl)-V-mathylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-n.aleinimid;(+) - 2 ~ [l- (2-hydroxy-3- (1-piperidino) propyl) -V-mathylthio-lH-indol-3-yl] -3- (lH-indol-3-yl) -N .aleinimid;

(+)-2-t1-(2-Hydroxy-3-(1-piperidino)propyl)-4,5-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2-t1- (2-hydroxy-3- (1-piperidino) propyl) -4,5-dimethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) - maleimide;

(+)-2-[1-(2-Hydroxy-3-(1-piperidino)propyl)-5,6-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [1- (2-hydroxy-3- (1-piperidino) propyl) -5,6-dimethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[1-(2-Hydroxy-3-(1-piperidino)propyl)-6,7-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [1- (2-hydroxy-3- (1-piperidino) propyl) -6,7-dimethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[4-Acetylamino-l-(2-hydroxy-3-(1-piperidino)propyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [4-acetylamino-l- (2-hydroxy-3- (1-piperidino) propyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-·) -2-[5-Acetylamino-l-(2-hydroxy-3-(l-piperidino)propyl) -IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) -2- [5-Acetylamino-1- (2-hydroxy-3- (1-piperidino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) - maleimide;

(-) -2-[6-Acetylamino-l-(2-hydroxy-3-(l-piperidino) propyl)'-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) -2- [6-Acetylamino-1- (2-hydroxy-3- (1-piperidino) propyl) -H-indol-3-yl] -3- (1H-indol-3-yl) - maleimide;

(-) -2-[7-Acetylamino-l-(2-hydroxy-3-(1-piperidino) propyl) -IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) -2- [7-Acetylamino-1- (2-hydroxy-3- (1-piperidino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide ;

(-)-2-[4-Amino-l-(2--hydroxy-3-( 1-piperidino) propyl)-lH-indol-3· "yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [4-Amino-1- (2-hydroxy-3- (1-piperidino) propyl) -1H-indole-3-yl] -3- (1H-indol-3-yl) maleimide;

(-) -2- [5-Amino-l-(2-hydroxy-3-( 1-piperidino) propyl)-lH-j.ndol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) -2- [5-Amino-1- (2-hydroxy-3- (1-piperidino) propyl) -1H-j-indol-3-yl] -3- (1H-indol-3-yl) maleimide;

(-)-2-[6-Amino-l-(2-hydroxy-3-(1-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [6-amino-l- (2-hydroxy-3- (1-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[7-Amino-l-(2-hydroxy-3-(1-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [7-amino-l- (2-hydroxy-3- (1-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[4-Benzyloxy-l-(2-hydroxy-3-(1-piperidino)propyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [4-benzyloxy-l- (2-hydroxy-3- (1-piperidino) propyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[5-Benzyloxy-l-(2-hydroxy-3-(l-piperidino)propyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [5-benzyloxy-l- (2-hydroxy-3- (l-piperidino) propyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[6-Benzyloxy-l-(2-hydroxy-3-(1-piperidino)propyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [6-benzyloxy-l- (2-hydroxy-3- (1-piperidino) propyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[7-Benzyloxy-l-(2-hydroxy-3-(1-piperidino)propyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [7-benzyloxy-l- (2-hydroxy-3- (1-piperidino) propyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[4-Brom-l-(2-hydroxy-3-(1-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [4-bromo-l- (2-hydroxy-3- (1-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[5-Brom-l-(2-hydroxy-3-(1-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [5-bromo-l- (2-hydroxy-3- (1-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[6-Brom-l-(2-hydroxy-3-(l-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [6-bromo-l- (2-hydroxy-3- (l-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

-117--117-

I-(2-hydroxy-3-( l-piperidir^) propyl )-lH-ir.dol-3-yl]-3-(lH-indol-3-yl)-maleinimid;1- (2-hydroxy-3- (1-piperidir ^) propyl) -1H-ir.dol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(-)-2-[4-Chlor-l-(2-hydroxy-3-(l-piperidino)propyl)-lH-indol-3-yl ] -3- (lH-indol-3-yl) -maleinimi.d;(-) - 2- [4-Chloro-1- (2-hydroxy-3- (1-piperidino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide .d;

(-)-2-[5-Chlor-l-(2-hydroxy-3-(1-piperidino)propyl)-IH-indol-3-yi]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [5-chloro-l- (2-hydroxy-3- (1-piperidino) propyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[6-Chlor-l-(2-hydroxy-3-(1-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3"yl)-maleinimid;(-) - 2- [6-chloro-l- (2-hydroxy-3- (1-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3 "yl) maleimide ;

(-)-2-[7-Chlor-l-(2-hydroxy-3-(l-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleiniroid;(-) - 2- [7-chloro-l- (2-hydroxy-3- (l-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) -maleiniroid ;

(-)-2-[4-Fluor-l-(2-hydroxy-3-(l-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [4-fluoro-l- (2-hydroxy-3- (l-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[5-Fluor-l-(2-hydroxy-3-(l-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [5-fluoro-l- (2-hydroxy-3- (l-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[6-Fluor-l-(2-hydroxy-3-(!-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [6-fluoro-l- (2-hydroxy-3 - (- piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[7-Fluor-l-(2-hydroxy-3-(1-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [7-fluoro-l- (2-hydroxy-3- (1-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[4-Hydroxy-l-(2-hydroxy-3-(l-pit^ridino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [4-hydroxy-l- (2-hydroxy-3- (l-pit ^ ridino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[5-Hydroxy-l-(2-hydroxy-3-(1-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol~3-yl)-maleinimid;(-) - 2- [5-hydroxy-l- (2-hydroxy-3- (1-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol ~ 3-yl) maleimide ;

(-)-2-[6-Hydroxy-l-(2-hydroxy-3-(l-piperidino)propyl)-lH-indol-3-ylj-3-(lH-indol-3-yl)-maleinimid?(-) - 2- [6-hydroxy-l- (2-hydroxy-3- (l-piperidino) propyl) -lH-indole-3-YLJ-3- (lH-indol-3-yl) maleimide?

(-)-2-[7-Hydroxy-l-(2-hydroxy-3-(1-piperidino)propyl)-7-hydroxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [7-hydroxy-l- (2-hydroxy-3- (1-piperidino) propyl) -7-hydroxy-lH-indol-3-yl] -3- (lH-indol-3- yl) maleimide;

-118--118-

(-) -2-[4-Trifluormethyl-l-(2-hydroxy-.^-(3.-pipe.ridino^rooyl) -4-trifluormethyl-lH-indol-3-yl]-3-(lH-inlol-3-yl)-maleinimid;(-) -2- [4-trifluoromethyl-1- (2-hydroxy-. ^ - (3-piperridino-roroyl) -4-trifluoromethyl-1H-indol-3-yl] -3- (1H- inlol-3-yl) maleimide;

(-)-2-[5-Trifluormethyl-l-(2-hydroxy-3-(l-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [5-trifluoromethyl-l- (2-hydroxy-3- (l-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[6-Trifluormethyl-l-(2-hydroxy-3~(l-piperidino)propyl)-6-trifluoriuethyl-lH-indol-3-yl ]-3-(lH-indol-3-yl)-maleinimid ;(-) - 2- [6-Trifluoromethyl-1- (2-hydroxy-3 - (1-piperidino) propyl) -6-trifluoro-ethyl-1H-indol-3-yl] -3- (1H-indole-3-yl) yl) -maleimide;

(-)-2-[7-Trifluormethyl-l-(2-hydroxy--3-( 1-piperidino) propyl) lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [7-Trifluoromethyl-1- (2-hydroxy-3- (1-piperidino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide ;

(-)-2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-4-nethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [l- (2-hydroxy-3- (1-piperidino) propyl) -4-nethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-5-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [l- (2-hydroxy-3- (1-piperidino) propyl) -5-methoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-) -2-[l-(2-Hydroxy-3-( 1-piperidino) propyl) --6-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) -2- [1- (2-Hydroxy-3- (1-piperidino) propyl) -6-methoxy-1H-indol-3-yl] -3- (1H-indol-3-yl) - maleimide;

(-)-2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-7-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [l- (2-hydroxy-3- (1-piperidino) propyl) -7-methoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-4,5-methylendioxylH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [l- (2-hydroxy-3- (1-piperidino) propyl) -4,5-methylendioxylH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-5,6-methylendioxylH-indol-3-yl]-3-(lH'-indol-3-yl)-maleinimid;(-) - 2- [l- (2-hydroxy-3- (1-piperidino) propyl) -5,6-methylendioxylH-indol-3-yl] -3- (lH'-indol-3-yl) - maleimide;

(-)-2-[1-(2-Hydroxy-3-(1-piperidino)propyl)-6,7-methylendioxylH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [1- (2-hydroxy-3- (1-piperidino) propyl) -6,7-methylendioxylH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-4-methyl-lH-indol-3-yl]-3-(lH-indo: -3-yl)-maleinimid;(-) - 2- [1- (2-Hydroxy-3- (1-piperidino) propyl) -4-methyl-1H-indol-3-yl] -3- (1H-indo-3-yl) - maleimide;

(-)-2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-5-methyl-lH-indol-3-y1]-3-(lH-indol-3-y1)-maleinimid;(-) - 2- [l- (2-hydroxy-3- (1-piperidino) propyl) -5-methyl-lH-indol-3-y1] -3- (lH-indol-3-y1) maleimide ;

-119--119-

(-) 2-[l-(2-Hydroxy-3-(l--piperidino)propyl) - 6-methyl-lH-indol-3-yl]-3-(lH--indol-3-yl)-maleinimid;(-) 2- [1- (2-Hydroxy-3- (1-piperidino) propyl) -6-methyl-1H-indol-3-yl] -3- (1H-indol-3-yl) - maleimide;

(-)- 2-· [l-( 2-Hydroxy-3-( 1-piperidino) propyl )-7-methyl-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- · [1- (2-Hydroxy-3- (1-piperidino) propyl) -7-methyl-1H-indol-3-yl] -3- (1H-indol-3-yl) - maleimide;

(-)-2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-4-nitro-lH-indol-3 yl]-3-(lH-indol-3~yl)-maleinimid;(-) - 2- [1- (2-Hydroxy-3- (1-piperidino) propyl) -4-nitro-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(-)-2-[l-(2-Hydroxy-3-(l-piperidino)propyl)-S-nitro-lH-indol-S-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [l- (2-hydroxy-3- (l-piperidino) propyl) -S-nitro-lH-indol-S-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-6-nitro-lH-indol-2-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [l- (2-hydroxy-3- (1-piperidino) propyl) -6-nitro-lH-indol-2-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-7-nitro-lH-indol-3 yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [1- (2-Hydroxy-3- (1-piperidino) propyl) -7-nitro-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(-)-2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-4-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-aialeinimid;(-) - 2- [l- (2-hydroxy-3- (1-piperidino) propyl) -4-methylthio-lH-indol-3-yl] -3- (lH-indol-3-yl) -aialeinimid ;

(-)-2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-5-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [l- (2-hydroxy-3- (1-piperidino) propyl) -5-methylthio-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide ;

(-)-2-[1-(2-Hydroxy-3-(1-piperidino)propyl)-6-methylthio-lH-indol-3-yl]-3-(lH-indol~3-yl)-maleinimid;(-) - 2- [1- (2-hydroxy-3- (1-piperidino) propyl) -6-methylthio-lH-indol-3-yl] -3- (lH-indol ~ 3-yl) maleimide ;

(-)-2-[l-( 2-F.ydroxy-3-( 1-piperidino) propyl )-7-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maloinimid;(-) - 2- [1- (2-F-hydroxy-3- (1-piperidino) propyl) -7-methylthio-1H-indol-3-yl] -3- (1H-indol-3-yl) -maloinimid;

(-)-2-[1-(2-Hydroxy-3-(1-piperidino)propyl)-4,5-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [1- (2-hydroxy-3- (1-piperidino) propyl) -4,5-dimethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[1-(2-Hydroxy-3-(1-piperidino)propyl)-5,6-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [1- (2-hydroxy-3- (1-piperidino) propyl) -5,6-dimethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[l-(2-Hydroxy-3-(l-piperidinc)propyl)-6,7-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [l- (2-hydroxy-3- (l-piperidinc) propyl) -6,7-dimethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

-120--120-

(±)-2-[4-Acetylamino-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3~yl)-maleinimid;(±) -2- [4-acetylamino-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3 ~ yl) maleimide;

(±)-2-[5-Acetylamino-l-(2,3-dihydroxypropyl)-IH-indol-3~yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [5-acetylamino-l- (2,3-dihydroxypropyl) -IH-indol-3 ~ yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[6-Acetylamino-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3· . (lH-indol-3-yl)-maleinimid;(±) -2- [6-Acetylamino-1- (2,3-dihydroxypropyl) -1H-indol-3-yl] -3. (LH-indol-3-yl) maleimide;

(±)-2-[7-Acetylamino-l-(2_/3-dihydroxypropyl)~lH-indol-3-yl]~3-(lH-indoJ-3-yl)-maleinimid;(±) -2- [7-acetylamino-1- (2 _/ 3-dihydroxypropyl) -1H-indol-3-yl] -3- (1H-indo-3-yl) -maleimide;

(±)-2-[4-Amino-l-(2,3-dihydroxypropyl)-lH-indol-3-yli-3-(lH-indol-3-yl)-maleinimid;(±) -2- [4-amino-l- (2,3-dihydroxypropyl) -lH-indol-3-yli-3- (lH-indol-3-yl) maleimide;

(±)-2-[5-Amino-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(±) -2- [5-amino-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

(±)-2-[6-Amino-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [6-Amino-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[7-Amino-l-(2,3-dihydroxypropy¹)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(±) -2- [7-Amino-1- (2,3-dihydroxypropyl- ¹ ) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±)-2-[4-Benzyloxy-i-(2,3-dihydroxypropy L)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [4-Benzyloxy-i- (2,3-dihydroxypropyl L) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±)-2-[5-Benzyloxy-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl) -maleinimid;(±) -2- [5-benzyloxy-l- (2, 3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[6-Benzylo>y-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [6-Benzylo> y-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[7-Benzyloxy-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [7-benzyloxy-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[4-Brom-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [4-bromo-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[5-Brom-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-\IH-indol-3-yl)-maleinimid;(±) -2- [5-bromo-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- \ IH-indol-3-yl) maleimide;

(±)-2-[6-Brom-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(±) -2- [6-bromo-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

(±)-2-[7-Brom-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [7-bromo-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[4-Chlor-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-( .H-indol-3-yl)-Maleinimid;(±) -2- [4-chloro-1- (2,3-dihydroxypropyl) -1H-indol-3-yl] -3- (.H-indol-3-yl) -maleimide;

(±)-2-[5-Chlor-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]'-3-(lH-indol-3-yl)-maleinimid;(±) -2- [5-chloro-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] '- 3- (lH-indol-3-yl) maleimide;

(±)-2-[6-Chlor-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(±) -2- [6-chloro-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

(±)-2-[7-Chlor-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(iH-indol-3-yl)-maleinimid;(±) -2- [7-chloro-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (iH-indol-3-yl) maleimide;

(±)-2-[4-Fluor-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [4-fluoro-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[5-Fluor-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [5-fluoro-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[6-Fluor-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [6-fluoro-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[7-Fluor-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [7-fluoro-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[4-Hydroxy-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [4-hydroxy-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[5-Hydroxy-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-malexnimid;(±) -2- [5-hydroxy-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) -malexnimid;

-122--122-

(±)-2-[6-Hydroxy-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(±) -2- [6-hydroxy-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

(±)-2-[7-Hydroxy-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(±) -2- [7-hydroxy-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

(±)-2-[4-Trifluormethyl-l-(2,3-dihydroxypropyl)-lH-indol-3-yl] 3-(lH-indol-3-yl)-maleinimid;(±) -2- [4-trifluoromethyl-1- (2,3-dihydroxypropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±) -2-[^!3-Trifluormethyl-l-(2,3-dihydroxypropyl) -lH-indol-3-yl] 3-(lH-indol-3-yl)-maleinimid;(±) -2- [ ^! 3-trifluoromethyl-1- (2,3-dihydroxypropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±)-2-[6-Trifluormethyl-l-(2,3-dihydroxypropyl)-lH-indol-3-yl] 3-(lH-indol-3-yl)-maleinimid;(±) -2- [6-trifluoromethyl-1- (2,3-dihydroxypropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±)-2-[7-Trifluormethyl-l-(2,3-dihydroxypropyl)-lH-indol-3-yl] 3-(lH-indol-3-yl)-maleinimid;(±) -2- [7-trifluoromethyl-1- (2,3-dihydroxypropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±)-2-[l-(2,3-Dihydroxypropyl)-4-methoxy-lH-indol-3-yl]-3-(l'-indol-3-yl)-maleinimid;(±) -2- [l- (2,3-dihydroxypropyl) -4-methoxy-lH-indol-3-yl] -3- (l'-indol-3-yl) maleimide;

(±)-2-[l-(2,3-Dihydroxypropyl)-5-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2,3-dihydroxypropyl) -5-methoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(2_/3-Dihydroxypropyl)-6-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [1- (2 _/ 3-dihydroxypropyl) -6-methoxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±)-2-t1-(2,3-Dihydroxypropyl)-V-methoxy-lH-indol-S-yl]-3-(IH-indol-3-yl)-maleinimid;(±) -2-t1- (2,3-dihydroxypropyl) -V-methoxy-lH-indol-S-yl] -3- (IH-indol-3-yl) maleimide;

(±)-2-[l-(2,3-Dihydroxypropyl)-4,5-methylendioxy-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(±) -2- [l- (2,3-dihydroxypropyl) -4,5-methylenedioxy-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

(±)-2-[1-(2,3-Dihydroxypropyl)-5,6«methylendioxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [1- (2,3-dihydroxypropyl) -5,6 'methylenedioxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

5 (±)-2-[l-(2,3-Dihydroxypropyl} -e^-methylendioxy-lH-indol-S-yl]-3-(lH-indol-3-yl)-malein.tTuid;5 (±) -2- [1- (2,3-dihydroxypropyl) -e-methylenedioxy-1H-indol-S-yl] -3- (1H-indol-3-yl) -malein.tTuide;

-123--123-

(±)-2-[l-(2,3-Dihydroxypropyl)-4-methyl-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(±) -2- [l- (2,3-dihydroxypropyl) -4-methyl-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

(±)-2-[l-( 2, 3-Dihydroxypropyl )-5-methyl-lH-indol-3~yl]--3-( IH-indol-3-yl)-maleinimid;(±) -2- [1- (2, 3-dihydroxypropyl) -5-methyl-1H-indol-3-yl] -3- (IH-indol-3-yl) -maleimide;

(±)-2-[l-(2,3-Dihydroxypropyl)-6-methyl-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(±) -2- [l- (2,3-dihydroxypropyl) -6-methyl-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

(±)-2-[l-(2,3-Dihydroxypropyl)-7-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl) -iaaleinimid;(±) -2- [1- (2,3-dihydroxypropyl) -7-methyl-1H-indol-3-yl] -3- (1H-indol-3-yl) -alAlmaleimide;

(±)-2-[l-(2,3~DihydroxyFropyl)-4-nit':o-lH-indol-3-yl]-3-(lH-indol-3-yl)-maieinimid;(±) -2- [l- (2,3 ~ DihydroxyFropyl) -4-nit ': o-lH-indol-3-yl] -3- (lH-indol-3-yl) -maieinimid;

(±)-2-[l-(2_/3-Dihydroxypropyl)-5-nitro-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [1- (2 _/ 3-dihydroxypropyl) -5-nitro-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(•J-)-2-[l-(2,3-Dihydroxypropyl)-6-nitro-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(J • -) - 2- [l- (2,3-dihydroxypropyl) -6-nitro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(2,3-Dihydroxypropyl)-7-nitro-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2,3-dihydroxypropyl) -7-nitro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-tl-(2,3-Dihydroxypropyl)-4-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2-tl (2,3-dihydroxypropyl) -4-methylthio-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(2,3-Dihydroxypropyl)-5-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2,3-dihydroxypropyl) -5-methylthio-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[1-(2,3-Dihydroxypropyl)-ö-methylthio-lH-indol-S-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [1- (2,3-dihydroxypropyl) -o-methylthio-lH-indol-S-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(2,3-Dihydroxypropyl)-7-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2,3-dihydroxypropyl) -7-methylthio-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[1-(2,3-Dihydroxypropyl)-4,5-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [1- (2,3-dihydroxypropyl) -4,5-dimethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

29797° -124- 29797 ° -124-

(±)-2-[l-(2,3-Dihydroxypropyl)-5,6-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [l- (2,3-dihydroxypropyl) -5,6-dimethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)~2-[l-(2,3-Dihydroxypropyl)-6,7-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) ~ 2- [l- (2,3-dihydroxypropyl) -6,7-dimethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[4-Acetylamino-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [4-acetylamino-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[5-Acetylamino-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3· (lH-indol-3-yl)-maleinimid;(+) - 2- [5-Acetylamino-1- (2,3-dihydroxypropyl) -1H-indol-3-yl] -3 · (1H-indol-3-yl) -maleimide;

(+)-2-[6-·Acetylamino-l-(2, 3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [6- * acetylamino-1- (2,3-dihydroxypropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[7-Acetylamino-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3· (lH-indol-3-yl)-maleinimid;(+) - 2- [7-Acetylamino-1- (2,3-dihydroxypropyl) -1H-indol-3-yl] -3 · (1H-indol-3-yl) -maleimide;

(+)-2-[4-Amino-l-(2,3-dihydroxypropyl)-lH-i ndol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(+) - 2- [4-amino-1- (2,3-dihydroxypropyl) -1H-i-nol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[5-Amino-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [5-amino-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[6-Amino-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [6-amino-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[7-Amino-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [7-amino-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[4-Benzyloxy-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [4-benzyloxy-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[5-Benzyloxy-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [5-benzyloxy-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[6-Benzyloxy-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [6-benzyloxy-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

-125--125-

(+)-2-[7-Benzyloxy-l-(2,3-dihydroxypropyl)-lH-indol-3-yI]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [7-benzyloxy-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[4-Brom-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(+) - 2- [4-bromo-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

(4)-2-[5--Brom-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(4) 2- [5 - bromo-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[6-Brom-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(+) - 2- [6-bromo-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

(+)-2-[7-Brom-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [7-bromo-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[4-Chlor-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(+) - 2- [4-chloro-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

(+)-2-[5-Chlor-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(+) - 2- [5-chloro-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

(+)-2-[6-Chlor-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [6-chloro-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[7-Chlor-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(+) - 2- [7-chloro-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

(+)-2-[4-Fluor-l-(2_/3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [4-fluoro-1- (2 _/ 3-dihydroxypropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[5-Fluor-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(+) - 2- [5-fluoro-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

(+)-2-[6-Fluor-l-(2,3-dihydroxypropyl)-IH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(+) - 2- [6-fluoro-l- (2,3-dihydroxypropyl) -IH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

5 (+)-2-[7-Fluor-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-mrileinim.id;5 (+) - 2- [7-Fluoro-1- (2,3-dihydroxypropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -milinimide;

-126--126-

(+)-2-[4-Hydroxy-l-(2,3-dihydroxypropyl)-lH-indol-3-ylJ-3-(IH-indol-3-yl)-maleinimid;(+) - 2- [4-hydroxy-l- (2,3-dihydroxypropyl) -lH-indol-3-YLJ-3- (IH-indol-3-yl) maleimide;

(+)-2~[5-Hydroxy-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl) -maleitiimid;(+) - 2 ~ [5-Hydroxy-1- (2,3-dihydroxypropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleitiimide;

(+)-2-[6-Hydroxy-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [6-hydroxy-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[7-Hydroxy-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [7-hydroxy-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[4-Trifluormethyl-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]· 3-(lH-indol-3-yl)-maleinimid;(+) - 2- [4-trifluoromethyl-1- (2,3-dihydroxypropyl) -1H-indol-3-yl] .3- (1H-indol-3-yl) -maleimide;

(+)-2-[5-Trifluormethyl-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [5-trifluoromethyl-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

( + )-2-16-Trifluormethyl-1-(2,3-dihydroxypropyl)-lH-indol-3-yl] 3-(lH-indol-3-yl)-maleinimid;(+) -2-16-trifluoromethyl-1- (2,3-dihydroxypropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[7-Trifluormethyl-1-(2,3-dihydroxypropyl)-lH-indol-3-yl]· 3-(lH-indol-3-yl)-maleinimid;(+) - 2- [7-trifluoromethyl-1- (2,3-dihydroxypropyl) -1H-indol-3-yl] .3- (1H-indol-3-yl) -maleimide;

(+) -2~[ 1-(2,3-Dihydroxypropyl) -iJ-methoxy-lH-indol-S-yl]-3-(IH-indol-3-yl)-maleinimid;(+) -2 - [1- (2,3-dihydroxypropyl) -i, J -methoxy-1H-indol-S-yl] -3- (IH-indol-3-yl) -maleimide;

(+)-2-[1-(2,3-Dihydroxypropyl)-5-methoxy-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(+) - 2- [1- (2,3-dihydroxypropyl) -5-methoxy-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

(+)-2-[l-(2,3-Dihydroxypropyl)-6-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2,3-dihydroxypropyl) -6-methoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(2,3-Dihydroxypropyl)-7-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2,3-dihydroxypropyl) -7-methoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[1-(2,3-Dihydroxypropyl)-4,5~methylendioxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [1- (2,3-dihydroxypropyl) -4,5 ~ methylenedioxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[1-(2,3-Dihydroxypropyl)-5, e-methylendioxy-lK-indol^- yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [1- (2,3-dihydroxypropyl) -5, e -methylenedioxy-1K-indol-1-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[I-(2,3-Dihydroxypropyl)-6,7-methylendioxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [I- (2,3-dihydroxypropyl) -6,7-methylenedioxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(2,3-Dihydroxypropyl)-4-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2,3-dihydroxypropyl) -4-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[1-(2,3-Dihydroxypropyl)-S-methyl-lH-indol-S-yl]-3-(IH-indol-3-yl)-maleinimid;(+) - 2- [1- (2,3-dihydroxypropyl) -S-methyl-lH-indol-S-yl] -3- (IH-indol-3-yl) maleimide;

(+)-2-[1-(2,3-Dihydroxypropyl)-6-methyl-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(+) - 2- [1- (2,3-dihydroxypropyl) -6-methyl-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

(+)-2-[1-(2,3-Dihydroxypropyl)-7-methyl-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(+) - 2- [1- (2,3-dihydroxypropyl) -7-methyl-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

(+)-2-[1-(2,3-Dihydroxypropyl)-4-nitro-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(+) - 2- [1- (2,3-dihydroxypropyl) -4-nitro-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

(+)-2-[1-(2,3-Dihydroxypropyl)-5-nitro-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(+) - 2- [1- (2,3-dihydroxypropyl) -5-nitro-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

(+)-2-[1-(2,3-Dihydroxypropyl)-6-nitro-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(+) - 2- [1- (2,3-dihydroxypropyl) -6-nitro-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

(+)-2-[1-(2,3-Dihydroxypropyl)-7-nitro-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(+) - 2- [1- (2,3-dihydroxypropyl) -7-nitro-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

(+)-2-[1-(2,3-Dihydroxypropyl)-4-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [1- (2,3-dihydroxypropyl) -4-methylthio-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[1-(2,3-Dihydroxypropyl)-S-methylthio-lH-indol-S-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [1- (2,3-dihydroxypropyl) -S-methylthio-lH-indol-S-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[1-(2,3-Dihydroxypropyl)-e-methylthio-lH-indol-S-yl]-3-(lH-indo.l -3-yl) -maleinimid;(+) - 2- [1- (2,3-dihydroxypropyl) -e-methylthio-1H-indol-S-yl] -3- (1H-indol-1,3-yl) -maleimide;

_!28-_! 28-

(+)-2-[l-(2,3-Dihydroxypropyl)-7-methylthio-lh-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2,3-dihydroxypropyl) -7-methylthio-lh-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[1-(2,3-Dihydroxypropyl)-4,5-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [1- (2,3-dihydroxypropyl) -4,5-dimethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(2,3-Dihydroxypropyl)-5,6-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2,3-dihydroxypropyl) -5,6-dimethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[1-(2,3-Dihydroxypropyl)-6,7-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [1- (2,3-dihydroxypropyl) -6,7-dimethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[4-Acetylamino-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [4-acetylamino-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[5-Acetylamino-l-(2,3-dihirlroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [5-Acetylamino-l- (2,3-dihirlroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[6-Acetylamino-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3· (lH-indol-3-yl)-maleinimid;(-) - 2- [6-Acetylamino-1- (2,3-dihydroxypropyl) -1H-indol-3-yl] -3 · (1H-indol-3-yl) -maleimide;

(-)-2=[7-Acetylamino-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2 = [7-acetylamino-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[4-Amino-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(-) - 2- [4-amino-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

(-)-2-[5-Amino-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [5-amino-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[6-Amino-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(-) - 2- [6-amino-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

(-)-2-[7-Amino-l-(2_/3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [7-Amino-l- (2 _/ 3-dihydroxypropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(-)-2-[4-Benzyloxy-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3· (lH-indol-3-yl)-maleinimid;(-) - 2- [4-Benzyloxy-1- (2,3-dihydroxypropyl) -1H-indol-3-yl] -3 · (1H-indol-3-yl) -maleimide;

-129--129-

(-)-2-[5-Benzyloxy-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [5-benzyloxy-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[6-Benzyloxy-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [6-benzyloxy-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[7-Benzyloxy-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [7-benzyloxy-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[4-Brom-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [4-bromo-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[5-Brom-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(-) - 2- [5-bromo-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

(-)-2-[6-Brom-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(-) - 2- [6-bromo-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

(-)-2-[7-Brom-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [7-bromo-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[4-Chlor-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [4-chloro-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[5-Chlor-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [5-chloro-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[6-Chlor-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [6-chloro-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[7-Chlor-l-(2_/3-dihydroxypropyl)~lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [7-chloro-L- (2 _/ 3-dihydroxypropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(-)-2-[4-Fluor-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(-) - 2- [4-fluoro-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

(-)-2-[5-Fluor-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [5-fluoro-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

-130--130-

(-)-2-[6-Fluor-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(iH-indol-3-yl)-maleinimid;(-) - 2- [6-fluoro-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (iH-indol-3-yl) maleimide;

(-)-2-[7"Fluor-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [7 "fluoro-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[4-Hydroxy-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(IH-.indol-3-yl)-maleinimid;(-) - 2- [4-hydroxy-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (IH-.indol-3-yl) maleimide;

(-)-2-[5-Hydroxy-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(-) - 2- [5-Hydroxy-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

(-)-2-[6-Hydroxy-l-(2,3~dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [6-hydroxy-l- (2,3 ~ dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[7-Hydroxy-l-(2,3-dihydroxypropyl)-IH-indol-3-yl]-3-(1H-indol-3-yl)-maleinimid;(-) - 2- [7-hydroxy-l- (2,3-dihydroxypropyl) -IH-indol-3-yl] -3- (1H-indol-3-yl) maleimide;

(-)-2-[4-Trifluormethyl-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [4-trifluoromethyl-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[5-Trifluormethyl-l-(2,3-dihydroxypropyl)-lH-indol-3-yl] 3-(lH-indol-3-yl)-naleinimid;(-) - 2- [5-Trifluoromethyl-1- (2,3-dihydroxypropyl) -1H-indol-3-yl] 3- (1H-indol-3-yl) -naleinimide;

(-)-2-[6-Trifluormethyl-l-(2_;3-dihydroxypropyl)-lH-indol-3-yl]· 3-(lH-indol-3-yl)-maleinimid;(-) - 2- [6-trifluoromethyl-1- (2 _: 3-dihydroxypropyl) -1H-indol-3-yl] .3- (1H-indol-3-yl) -maleimide;

(-)-2-[7-Trifluormethyl-l-(2,3-dihydroxypropyl)-lH-indol-3-yl] 3-(lH-indol-3-yl)-maleinimid;(-) - 2- [7-Trifluoromethyl-1- (2,3-dihydroxypropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(-)-2-[1-(2,3-Dihydroxypropyl)-4-methcxy-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(-) - 2- [1- (2,3-dihydroxypropyl) -4-methcxy-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

(-)-2-[l-(2,3-Dihydroxypropyl)-5-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [l- (2,3-dihydroxypropyl) -5-methoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[1-(2,3-Dihydroxypropyl)-ö-methoxy-lH-indol-S-yl]-3-(IH-indol-3-yl)-maleinimid;(-) - 2- [1- (2,3-dihydroxypropyl) -o-methoxy-lH-indol-S-yl] -3- (IH-indol-3-yl) maleimide;

297S7O -131- 297S7O -131-

{ -) -2-[ 1- (2_; 3-Dihydroxypropyl) -7-metheexy-lH-ihdor-3-y"l ] -¹J- (IH-indol-3-yl)-maleinimid;{-) -2- [1- (2 _: 3-dihydroxypropyl) -7-methexyl-1H-i-iodo-3-yl] ^-1- J- (1H-indol-3-yl) -maleimide;

(-)-2-[l-(2,3-Dihydroxypropyl)-4,5-methylendioxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [l- (2,3-dihydroxypropyl) -4,5-methylenedioxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[1-(2,3-Dihydroxypropyl)-5,6-methylendioxy-lH-indol-3-" yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [1- (2,3-Dihydroxypropyl) -5,6-methylenedioxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(-)-2-[l-(2,3-Dihydroxypropyl)-6,7-methylendioxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [l- (2,3-dihydroxypropyl) -6,7-methylenedioxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-) -2-[ 1- (2, 3-Dihydroxypropyl) -4-mp.thyl-lH-indol-3-yl]-3- (IH-indol-3-yl)-maleinimid;(-) -2- [1- (2, 3-Dihydroxypropyl) -4-methyl-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(-)-2-[l-(2,3-Dihydroxypropyl)-5-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [l- (2,3-dihydroxypropyl) -5-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[1-(2,3-Dihydroxypropyl)-e-methyl-lH-indol-S-yl]-3-(IH-indol-3-yl)-maleinimid;(-) - 2- [1- (2,3-dihydroxypropyl) -e-methyl-lH-indol-S-yl] -3- (IH-indol-3-yl) maleimide;

(-)-2-[l-(2_/3-Dihydroxypropyl)-7-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-taleinimid;(-) - 2- [1- (2 _/ 3-Dihydroxypropyl) -7-methyl-1H-indol-3-yl] -3- (1H-indol-3-yl) -thaleinimide;

(-)-2-[1-(2,3-Dihydroxypropyl)-4-nitro-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(-) - 2- [1- (2,3-dihydroxypropyl) -4-nitro-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

(-)-2-[1-(2,3-Dihydroxypropyl)-5-nitro-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(-) - 2- [1- (2,3-dihydroxypropyl) -5-nitro-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

(-)-2-tl-(2,3-Dihydroxypropyl)"6-nitro-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2-tl (2,3-dihydroxypropyl) "6-nitro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[1-(2,3-Dihydroxypropyl)-7-nitro-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid; (-) -2- [1- (2,3-dihydroxypropyl) -7-nitro-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(-)-2-[l-(2,3-Dihydroxypropyl)-4-methylthio-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(-) - 2- [l- (2,3-dihydroxypropyl) -4-methylthio-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

-¹³²"- ¹³² "

(-)-2-[l-(2,3-Dihydroxypropyl)-5-methyltnio"lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- maleimide [l- (2,3-dihydroxypropyl) -5-methyltnio "lH-indol-3-yl] -3- (lH-indol-3-yl);

(-)-2-[l-(2_/3-Dihydroxypropyl)-6-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleiniroid;(-) - 2- [1- (2 _/ 3-Dihydroxypropyl) -6-methylthio-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleiniroid;

(-)-2-[l-(2,3-Dihydroxypropyl)-7-methylthio-lH-indol-3-yl]-3-' (lH-indol-3-yl)-maleiniraid;(-) - 2- [1- (2,3-Dihydroxypropyl) -7-methylthio-1H-indol-3-yl] -3- '(1H-indol-3-yl) -maleiniraid;

(-)-2-[1-(2,3-Dihydroxypropy1)-4,5-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [1- (2,3-Dihydroxypropy1) -4,5-dimethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[1-(2,3-Dihydroxypropy1)-5,6-dimethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-malfjinimid;(-) - 2- [1- (2,3-Dihydroxypropy1) -5,6-dimethoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) -malfjinimid;

(-) -2- [ 1« (2 , 3-Dihydroxypropyl) -6,7-dimethoxy-lH-indol-3-y.l j -3-(IH-: idol-3-yl)-maleinimid;(-) -2- [1 "(2, 3-Dihydroxypropyl) -6,7-dimethoxy-1H-indol-3-yl-3-yl (IH-idol-3-yl) -maleimide;

2-[4-Acetylamino-l-(3-hydroxypropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [4-acetylamino-l- (3-hydroxypropyl) -lH-indol-3-yl] -maleimide -3- (IH-indol-3-yl);

2-[5-Acetylamino-l-(3-hydroxypropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [5-Acetylamino-l- (3-hydroxypropyl) -lH-indol-3-yl] -maleimide -3- (IH-indol-3-yl);

2-[6-Acetylamino-l-(3-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [6-acetylamino-l- (3-hydroxypropyl) -lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

2-[7-Acetylamino-l-(3-hydroxypropyl)-lH-indol-3-yl]-3-(IH-inciol-3-yl)-maleinimid;2- [7-acetylamino-l- (3-hydroxypropyl) -lH-indol-3-yl] -3- (IH-inciol-3-yl) maleimide;

2-[4-Amino-l-(3-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [4-amino-l- (3-hydroxypropyl) -lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

2-[5-Amino-l-(3-hydroxypropyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [5-Amino-l- (3-hydroxypropyl) -IH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

2- [ 6-Amino-l- (3-hydroxypropyl) -lH-indol-3-y.\ ] -3- (lH-indol-3-yl)-maleinimid;2- [6-amino-1- (3-hydroxypropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

-133--133-

2-[7-Amino-l-(3-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl) -rnaleinimid;2- [7-amino-1- (3-hydroxypropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -incaleinimide;

ii-[4-Benzyloxy-l-(3-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;ii- [4-benzyloxy-l- (3-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[5-Benzyloxy-l-(3-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol- 3-yl)-maleinimid;2- [5-Benzyloxy-1- (3-hydroxypropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[6-Benzyloxy-l-(3-hydroxypropyl)-lH-indol-3-ylj-3-(lH-indol-3-yl)-roaleinimid;2- [6-benzyloxy-l- (3-hydroxypropyl) -lH-indol-3-YLJ-3- (lH-indol-3-yl) -roaleinimid;

2-[7-Benzyloxy-l-(3-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [7-benzyloxy-l- (3-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[4-Brom-l-(3-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [4-bromo-l- (3-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[5-Brom-l-(3-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [5-bromo-l- (3-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[6-Brom-l-(3-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [6-bromo-l- (3-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[7-Brom-l-(3-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [7-bromo-l- (3-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[4-Chlor-l-(3-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-0 y1)-maleinimid;2- [4-chloro-1- (3-hydroxypropyl) -1H-indol-3-yl] -3- (1H-indol-3-o-yl) -maleimide;

2-[5-Chlor-l-(3-hydroxypropyl)-lH-ir.dol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [5-chloro-l- (3-hydroxypropyl) -lH-ir.dol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[6-Chlor-l-(3-hydroxypropyl)-lH-indol-3-yl]-3-(lH~indol-3-yl)-maleinimid;2- [6-chloro-l- (3-hydroxypropyl) -lH-indol-3-yl] -3- (lH ~ indol-3-yl) maleimide;

2-[7-Chlor-l-(3-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [7-chloro-l- (3-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

-134--134-

2-[4-Fluor-l-(3-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-ialeinimid;2- [4-fluoro-l- (3-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) -ialeinimid;

2-[5-Fluor-l-(3-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [5-fluoro-l- (3-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[6-Fluor-l-(3-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-. yl)-maleinimid;2- [6-fluoro-1- (3-hydroxypropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[7-Fluor-l-(3-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl) -maleinimic¹ ·2- [7-Fluoro-1- (3-hydroxypropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleinimic ¹ ·

2-[4-Hydroxy-l-(3-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [4-hydroxy-l- (3-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[5-Hydroxy-l-(3-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [5-hydroxy-l- (3-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[6-Hydroxy-l-(3-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [6-hydroxy-l- (3-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[7-Hydroxy-l-(3-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [7-hydroxy-l- (3-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[4-Trifluormethyl-l-(3-hydroxypropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [4-trifluoromethyl-l- (3-hydroxypropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[5-Trifluormethyl-l-(3-hydroxyp/opyl)-5-trifluormethyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleiniraid;2- [5-trifluoromethyl-l- (3-hydroxycymenes / opyl) -5-trifluoromethyl-lH-indol-3-yl] -3- (lH-indol-3-yl) -maleiniraid;

2-[6-Trifluormethyl-l~(3-hydroxypropyl)-6-trifIuormethyl-1H-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [6-trifluoromethyl-l ~ (3-hydroxypropyl) -6-trifIuormethyl-1H-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[7-Trifluormethyl-1-(3-hydroxypropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [7-Trifluoromethyl-1- (3-hydroxypropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[l-(3-Hydroxypropyl)-4~methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-hydroxypropyl) -4 ~ methoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

29?9?O -135- 29? 9? O -135-

>.-[ l-( 3-Hydroxypropy l)-5-methoxy-lH-ir.dol-3-y i]-3- (lH-indol-3-/1)-maleinimid; > - [1- (3-hydroxypropyl) -5-methoxy-1H-diol-3-yl] -3- (1H-indole-3/1) -maleimide;

2-[l-(3-Hydroaypropyl)-6-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-Hydroaypropyl) -6-methoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

L¹I 2-[l-(3-Hydroxypropyl)-7-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;L ¹ I 2- [1- (3-hydroxypropyl) -7-methoxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[l-(3-Hydroxypropyl)-4,5-methylendioxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-hydroxypropyl) -4,5-methylenedioxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[1-(3-Hydroxypropyl)-5,ö-methylendioxy-lH-indol-S-yl·]-3-(IH-indol-3-yl)-maleinimid;2- [1- (3-hydroxypropyl) -5, ö-methylenedioxy-lH-indol-S-yl ·] -3- (IH-indol-3-yl) maleimide;

2-[l-(3-Hydroxypropyl)-6,7-methylendioxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-hydroxypropyl) -6,7-methylenedioxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-Hydroxypropyl)-4-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-hydroxypropyl) -4-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-Hydroxypropyl)-5-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-hydroxypropyl) -5-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-Hydroxypropyl)-6-methyl-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-hydroxypropyl) -6-methyl-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-Hydroxypropyl)-7-methyl-lH-indol-J-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-hydroxypropyl) -7-methyl-lH-indole-J-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-Hydroxypropyl)-4-nitro-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-hydroxypropyl) -4-nitro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-Hydroxypropyl)-5-n..tro-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-hydroxypropyl) -5-n..tro-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

5 2-[l-(3-Hydroxypropyl)-6-nitro-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;5 2- [1- (3-hydroxypropyl) -6-nitro-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

-136--136-

2-[l-(3-Hydroxypropyl)-7-nitro-lH-indol-3-ylj-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-hydroxypropyl) -7-nitro-lH-indol-3-YLJ-3- (lH-indol-3-yl) maleimide;

2-[l-(3-Hydroxypropyl)-4-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3-hydroxypropyl) -4-methylthio-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-Hydroxypropyl)-5-methylthio-lH-indol~j· yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (3-hydroxypropyl) -5-methylthio-1H-indol-1-yl] -3- (1H-indol-3-yl) -maleimide;

2-[1-(3-Hydroxypropyl)-6-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (3-hydroxypropyl) -6-methylthio-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[1-(3-Hydroxypropyl)-7-methylthio-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [1- (3-hydroxypropyl) -7-methylthio-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[1-(3-Hydroxypropyl)-4,5-dimethoxy-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (3-hydroxypropyl) -4,5-dimethoxy-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[l-(3-Hydroxypropyl) -5, 6-diiaetho::y-lH-indol-3-yl] -3- (IH-indol-3-yl)-maleinimid;2- [1- (3-hydroxypropyl) -5,6-diiaetho-y-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[1-(3-Hydroxypropyl)-6,7-dimethoxy-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (3-hydroxypropyl) -6,7-dimethoxy-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[4-Acetylamino-l-(3-isothiocyanatopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [4-acetylamino-l- (3-isothiocyanatopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[5-Acetylamino-l-(3-isothiocyanatopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleiniraid;2- [5-Acetylamino-l- (3-isothiocyanatopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) -maleiniraid;

2-[6-Acetylamino-l-(3~isothiocyanatopropyl)-IH indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [6-Acetylamino-1- (3-isothiocyanatopropyl) -IH-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[7-Acetylamino-l-(3-isothiocyanatopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [7-acetylamino-l- (3-isothiocyanatopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[4-Amino-l-(3-isothiocyanatopropyl)-lH-indol-3-yl]-3-(lH-indol~3-yl) -maleiniiaid;2- [4-Amino-l- (3-isothiocyanatopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleiniaide;

Z9797O -137- Z9797O -137-

2-[5-Amino-l-(3-isothiocyanatopropyl)-lH-indol-j-yl]-3-(lH-indol-3-yl)-maleinimid;2- [5-Amino-l- (3-isothiocyanatopropyl) -lH-indol-j-yl] -3- (lH-indol-3-yl) maleimide;

2-[6-Amino-l-(3-lsothiocyanatopropy1)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [6-amino-l- (3-lsothiocyanatopropy1) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[7-Amino-1-(3-lsothiocyanatopropy1)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [7-amino-1- (3-lsothiocyanatopropy1) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[4-Benzyloxy-l-(3-isothiocyanatopropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [4-benzyloxy-l- (3-isothiocyanatopropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[5-Benzyloxy-]-(3-isothiocyanatopropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [5-benzyloxy -] - (3-isothiocyanatopropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[6-Benzyloxy-l-(3-isothiocyanatopropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [6-benzyloxy-l- (3-isothiocyanatopropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[7-Benzyloxy-l-(3-isothiocyanatopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [7-benzyloxy-l- (3-isothiocyanatopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[4-Brom-l-(3-isothiocyanatopropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [4-bromo-l- (3-isothiocyanatopropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[5-Brom-l-(3-isothiccyanatopropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [5-bromo-l- (3-isothiccyanatopropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[6-Brom-l-(3-isothiocyanatopropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [6-bromo-l- (3-isothiocyanatopropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[7-Brom-l-(3-isothiocyanatopropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [7-bromo-l- (3-isothiocyanatopropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[4-Chlor-l-(3-isothiocyanatopropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;maleimide 2- [4-chloro-l- (3-isothiocyanatopropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl);

2-[5-Chlor-l-(3-is jthiocyanatopropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [5-chloro-1- (3-isothiocyanatopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

-138--138-

2-[6-Chlor-l-(3-isothiocyanatopropyl)-lH-indol-3-yl]-J-(IH-indol-J-yl)-maleinimid;2- [6-chloro-l- (3-isothiocyanatopropyl) -lH-indol-3-yl] -J- (IH-indol-J-yl) maleimide;

2-[7-Chlor-l-(3-isothiocyanatopropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [7-chloro-l- (3-isothiocyanatopropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[4-Fluor-l-(3-isothiocyanatopropyl)-lH-indol-3-yl]-3-(IH-. indol-3-yl)-maleinimid;2- [4-fluoro-1- (3-isothiocyanatopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[5-Fluor-l-(3-isothiocyanatopropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-raaleinimid;2- [5-fluoro-l- (3-isothiocyanatopropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) -raaleinimid;

2-[6-Fluor-l-(3-isothiocyanatopropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-Maleinimid;2- [6-fluoro-l- (3-isothiocyanatopropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[7-Fluor--l-(3-isothiocyanatopropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [7-fluoro - l- (3-isothiocyanatopropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[4-Hydroxy-l-(3-isothiocyanatopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [4-hydroxy-l- (3-isothiocyanatopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[5-Hydroxy-l-(3-isothiocyanatopropyl)-lH-indol-3-yl]-3-(IH-indoi-3-yl)-maleinimid;2- [5-hydroxy-l- (3-isothiocyanatopropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[6-Hydroxy-1-(3-isothiocyanatopropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [6-hydroxy-1- (3-isothiocyanatopropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[7-Hydroxy-l-(3-isothiocyanatopropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [7-hydroxy-l- (3-isothiocyanatopropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[4-Trifluormethy].-l-(3-isothiocyanatopropyl) -lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [4-trifluoromethyl] .- 1- (3-isothiocyanatopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[5-Trifluormethyl-l-(3-isothiocyanatopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [5-trifluoromethyl-l- (3-isothiocyanatopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[6-Trifluormethyl-l-(3-isothiocyanatopropyl)-lH-indol-3-yl] 3-(lH-indol-3-yl)-maleinimid;2- [6-trifluoromethyl-1- (3-isothiocyanatopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

-₁₃₉-- ₁₃₉ -

2-[7-Trifluormethyl-l-(3-isothiocyan3topropyi)· IH-indol-3-yl] 3-(lH-indol-3-yl)-maleinimid;2- [7-trifluoromethyl-1- (3-isothiocyanato) propyl] -H-indol-3-yl] 3- (1H-indol-3-yl) -maleimide;

2-(lH-Indol-3-yl)-3-[l-(3-isothiocyanatopropyl)-4-methoxy-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [l- (3-isothiocyanatopropyl) -4-methoxy-lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[l-(3-isothiocyanatopropyl)-5-methoxy-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [l- (3-isothiocyanatopropyl) -5-methoxy-lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[l-(3-isothiocyanatopropyl)-6-methoxy-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [l- (3-isothiocyanatopropyl) -6-methoxy-lH-indol-3-yl] -maleimide;

2-(lH~Indol-3-yl)-3-[l-(3-isothiocyanatopropyl)-7-methoxy-lH-IC inaol-3-yl]-maleinimid;2- (1H-indol-3-yl) -3- [1- (3-isothiocyanatopropyl) -7-methoxy-1H-IC-inαol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-'J-[l-(3-isothiocyanatopropyl) -4,5-methylendioxy-lH-indol-3-yl]-maleinimid;2- (1H-indol-3-yl) - 'J- [1- (3-isothiocyanatopropyl) -4,5-methylenedioxy-1H-indol-3-yl] -maleimide;

2-(lH-Indol--3 yl) -3-[l-(3-isothiocyanatopropyl) -5,6-methylendioxy-lH-indol-3-yl]-maleinimid;2- (1H-indol-3- yl) -3- [1- (3-isothiocyanatopropyl) -5,6-methylenedioxy-1H-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[l-(3-isothiocyanatopropyl)-6,7-methylendioxy-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [l- (3-isothiocyanatopropyl) -6,7-methylenedioxy-lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-tl-(3-isothiocyanatopropyl)-4-methyl-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3-tl (3-isothiocyanatopropyl) -4-methyl-lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[l-(3-isothiocyanatopropyl)-5-methyl-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [l- (3-isothiocyanatopropyl) -5-methyl-lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[1-(3-isothiocyanatopropyl)-6-methyl-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [1- (3-isothiocyanatopropyl) -6-methyl-lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[l-(3-isothiocyanatopropyl)-7-methyl-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [l- (3-isothiocyanatopropyl) -7-methyl-lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[l-(3-isothiocyanatopropyl)-4-nitro-lH-indo\-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [l- (3-isothiocyanatopropyl) -4-nitro-lH-indo \ -3-yl] -maleimide;

-140--140-

2-(lH-Indol-3-yl)-3-[l-(3-isothiocyd'natupropyl;-5-nitro-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [l- (3-isothiocyd'natupropyl -5-nitro-lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[l-(3-isothiocyanatopropyl)-6-nitro-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [l- (3-isothiocyanatopropyl) -6-nitro-lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[l-(3-isothiocyanatopropyl)-7-nitro-lH-. indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [l- (3-isothiocyanatopropyl) -7-nitro-LH. indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3—[1-(3-isothiocyanatopropyl)-4-methylthiolH-indol-3-ylj-maleinimid;2- (lH-indol-3-yl) -3- [1- (3-isothiocyanatopropyl) -4-methylthiolH-indol-3-YLJ-maleimide;

2-(lH-Indol-3-yl)-3-[1-(3-isothiocyanatopropyl)-5-methylthiolH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [1- (3-isothiocyanatopropyl) -5-methylthiolH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[1-(3-isothiocyanatopropyl)-6-methylthiolH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [1- (3-isothiocyanatopropyl) -6-methylthiolH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[l-(3-isothiocyanatopropyl)-7-methylthiolH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [l- (3-isothiocyanatopropyl) -7-methylthiolH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[1-(3-isothiocyanatopropyl)-4,5-dimethoxylH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [1- (3-isothiocyanatopropyl) -4,5-dimethoxylH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[l-(3-isothiocyanatopropyl)-5,6-dimethoxylH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [l- (3-isothiocyanatopropyl) -5,6-dimethoxylH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[l-(3-isothiocyanatopropyl)-6,7-dimethoxylH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [l- (3-isothiocyanatopropyl) -6,7-dimethoxylH-indol-3-yl] -maleimide;

(±)-2-[4-Acetylamino-1-(2-methoxy-3-dimethylaminopropy1)-IH-indol-3-yl]-3-(lH-indcl-3-yl)-maleinimid;(±) -2- [4-acetylamino-1- (2-methoxy-3-dimethylaminopropy1) -IH-indol-3-yl] -3- (lH-indcl-3-yl) maleimide;

(±)-2-[5-Acetylamino-l-(2-methoxy-3-dimethylaminopropyl)-IH-indol-3-yl]-3-(iH-indol-3-yl)-maleinimid;(±) -2- [5-acetylamino-l- (2-methoxy-3-dimethylaminopropyl) -IH-indol-3-yl] -3- (iH-indol-3-yl) maleimide;

(±)-2-t6-Acetylamino-l-(2-methoxy-3-dimethylaminopropyl)-lH-iniol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2-t6-acetylamino-l- (2-methoxy-3-dimethylaminopropyl) -lH-iniol-3-yl] -3- (lH-indol-3-yl) maleimide;

-141--141-

(±) -2-[⁷-Acv?.tylainino-l- (2-methoxy-3-diii.ethyiaiuInopi:opyl) -IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [ ^7- Acv? .Tylainino-1- (2-methoxy-3-di (ethylenediol) opyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) maleimide;

(±)-2-[4-Amino-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [4-amino-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[5-Amino-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-. yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [5-amino-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-. maleimide yl] -3- (lH-indol-3-yl);

(±)-2-[6-Amino--l-( 2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl] -3- (lH-inci.· .-3-yl)-maleinimid;(±) -2- [6-Amino-1- (2-methoxy-3-dimethylaminopropyl) -1H-indol-3-yl] -3- (1H -inci-.3-yl) -maleimide;

(±)-2-[7-Amino-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [7-amino-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[4-Benzyloxy-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yi)-maleinimid;(±) -2- [4-benzyloxy-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[5-Benzyloxy-l-(2-methoxy-3-dimethylaminopropyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [5-benzyloxy-l- (2-methoxy-3-dimethylaminopropyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[6-Benzyloxy-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [6-benzyloxy-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[7-Benzyloxy-l-(2-methoxy-3-dimethylaminopropy1)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [7-benzyloxy-l- (2-methoxy-3-dimethylaminopropy1) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[4-Brom-1-(2-methoxy-3-dimethylaminopropy1)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [4-bromo-1- (2-methoxy-3-dimethylaminopropy1) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[5-Brom-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [5-bromo-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[6-Brom-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yi]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [6-bromo-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

5 (±)-2-[7-Brom-l-(2-methoxy-3-dimethylaminopropy1)-lH-indol-3-yl]-3 -(lH-indol-3-yl)-maleinimid;5 (±) -2- [7-bromo-1- (2-methoxy-3-dimethylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

-142--142-

(±) -2-[4-Chlor-l-(2-methoxy-3-dimethylciminoprcpyl) -lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [4-chloro-1- (2-methoxy-3-dimethylciminoprcyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±)-2-[5-Chlor-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [5-chloro-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[6-Chlov-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [6-Chlov-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[7-Chlor-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [7-chloro-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[4-Fluor-l"(2-methoxy-3-dimGthylaminopropyl)-lif-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [4-fluoro-l '(2-methoxy-3-dimGthylaminopropyl) -lif-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[5-Fluor-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3~yl)-maleinimid;(±) -2- [5-fluoro-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3 ~ yl) maleimide;

(±)-2-[6-Fluor-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [6-fluoro-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[7-Fluor-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [7-fluoro-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[4-Hydroxy-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [4-hydroxy-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[5-Hydroxy-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [5-hydroxy-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[6-Hydroxy-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [6-hydroxy-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[7-Hydroxy-l-(2-roethoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [7-hydroxy-l- (2-roethoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[4-Tri fluormethy1-1-(2-methoxy-3-dimethylaminopropy1)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [4-trifluoromethyl] -1- (2-methoxy-3-dimethylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

29197ο -143- 29197o -143-

(±)-2-[5-Trifluormethyl-l-(2-methoxy-3-dimethylami:iopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [5-trifluoromethyl-l- (2-methoxy-3-dimethylamino: iopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[6-Trifluormethyl-l-(2-methcxy-3-dimethylaminopropyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [6-trifluoromethyl-l- (2-methcxy-3-dimethylaminopropyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[7-Triflaormethyl-1-(2-methoxy-3-dimethylaminopropyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) -2- [7-Triflaormethyl-1- (2-methoxy-3-dimethylaminopropyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-(lH-Indol-3-yl)-3-[4-methoxy-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;(±) -2- (lH-indol-3-yl) -3- [4-methoxy-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide;

(±)-2-(lH-indol-3-yl)-3-[5-methoxy-l-(2-methoxy-3~ dimethylaminop ropyl)-lH-indol-3-yl]-maleinimid;(±) -2- (1H-indol-3-yl) -3- [5-methoxy-1- (2-methoxy-3-dimethylaminopropyl) -1H-indol-3-yl] -maleimide;

(±)-2-(lH-Indol-3-yl)-3-[6-methoxy-l-(2-methoxy-3-d iiiie thy 1 am inop ropyl) -lH-indol-3-yl] -maleinimid;(±) -2- (1H-Indol-3-yl) -3- [6-methoxy-1- (2-methoxy-3-d, thio 1-inopropyl) -1H-indol-3-yl] - maleimide;

(±)-2-(lH-Indol-3-yl)-3-[7-methoxy-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;(±) -2- (lH-indol-3-yl) -3- [7-methoxy-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide;

(±)-2-(lH-Indol-3-yl)-3-[l-(2-methoxy-3-dimethylaminopropyl)-4,5-methylendioxy-lH-indol-3-yl]-maleinimid;(±) -2- (lH-indol-3-yl) -3- [l- (2-methoxy-3-dimethylaminopropyl) -4,5-methylenedioxy-lH-indol-3-yl] -maleimide;

(±)-2-(lH-Indol-3-y1)-3-[1-(2-methoxy-3-dimethylaminopropy1)-5,6-methylendioxy-lK-indol-3-yl]-maleinimid;(±) -2- (lH-indol-3-y1) -3- [1- (2-methoxy-3-dimethylaminopropy1) -5,6-methylenedioxy-lK-indol-3-yl] -maleimide;

(±)-2-(lH~Indol-3-yl)-3-[l-(2-methoxy-3-dimethylaminopropyl)-6,7-methylendioxy-lH-indol-3-yl]-maleinimid;(±) -2- (lH ~ indol-3-yl) -3- [l- (2-methoxy-3-dimethylaminopropyl) -6,7-methylenedioxy-lH-indol-3-yl] -maleimide;

(±)-2-(lH-Indol-3-yl)-3-[l-(2-methoxy-3-dimethylaminopropyl)-4-methyl-lH-indol-3-yl]-maleinimid;(±) -2- (lH-indol-3-yl) -3- [l- (2-methoxy-3-dimethylaminopropyl) -4-methyl-lH-indol-3-yl] -maleimide;

(±)-2-(lH-Indol-3-yl)-3-[l-(2-roethoxy-3-dimethylaminopropyl)-5-methyl-lH-indol-3-yl]-maleinimid;(±) -2- (lH-indol-3-yl) -3- [l- (2-roethoxy-3-dimethylaminopropyl) -5-methyl-lH-indol-3-yl] -maleimide;

(±)-2-(lH-Indol-3-yl)-3-[l-(2-methoxy-3-dimethylaminopropyl)-6-methyl-lH-indol-3-yl]-maleinimid;(±) -2- (lH-indol-3-yl) -3- [l- (2-methoxy-3-dimethylaminopropyl) -6-methyl-lH-indol-3-yl] -maleimide;

-144--144-

(±)-2-(lH-Indol-3-yl)-3-[l-(2-methoxy-3-dimethylaminopropy])-7-methyl-lH-indol-3-yl]-maleinimid;(±) -2- (1H-indol-3-yl) -3- [1- (2-methoxy-3-dimethylaminopropyl) -7-methyl-1H-indol-3-yl] -maleimide;

(±) -2-(lH-Indol-3-yl) -3-[l-(2-methoxy-^-dimethylaminopropyl) -4-nitro-lH-indol-3-yl]-maleinimid;(±) -2- (1H-indol-3-yl) -3- [1- (2-methoxy-1-dimethylaminopropyl) -4-nitro-1H-indol-3-yl] -maleimide;

(±)-2-(lH-Indol-3-yl)-:i-[l-(2-methoxy-3-dimethylaminopropyl)-5-nitro-IH-i ndol-3-yl]-maleinimid;(±) -2- (1H-indol-3-yl) -: i- [1- (2-methoxy-3-dimethylaminopropyl) -5-nitro-1H-i-indol-3-yl] -maleimide;

(±)-2-(lH-Indol-3-yl)-3-[l-(2-methoxy-3-dimethylaminopropyl)-6-nitro-lH-indol-3-yl]-maleinimid;(±) -2- (lH-indol-3-yl) -3- [l- (2-methoxy-3-dimethylaminopropyl) -6-nitro-lH-indol-3-yl] -maleimide;

(±)-2-(lH-Indol-3-yl)-3-[l-(2-methoxy-3-dimethylamin6propyJ)-7-nitro-lH-indol-3-yl]-maleinimid;(±) -2- (lH-indol-3-yl) -3- [l- (2-methoxy-3-dimethylamin6propyJ) -7-nitro-lH-indol-3-yl] -maleimide;

(±)-2-(lH-Indol-3-yl)-3-[l-(2-methoxy-3-dimethylaminopropyl)-4-methylthio-lH-indol-3-yl]-maleinimid;(±) -2- (lH-indol-3-yl) -3- [l- (2-methoxy-3-dimethylaminopropyl) -4-methylthio-lH-indol-3-yl] -maleimide;

(±)-2-(lH-Indol-3-yl)-3-[l-(2-methoxy-3-dimethylaminopropyl)-5· methylthio-lH-indol-3-yl]-maleinimid;(±) -2- (1H-indol-3-yl) -3- [1- (2-methoxy-3-dimethylaminopropyl) -5-methylthio-1H-indol-3-yl] -maleimide;

(±)-2-(lH-Indol-3-yl)-3-[l-(2-methoxy-3-dimethylaminopropyl)-6-methyithio-lH-indol-3-yl]-maleinimid;(±) -2- (lH-indol-3-yl) -3- [l- (2-methoxy-3-dimethylaminopropyl) -6-methylthio-lH-indol-3-yl] -maleimide;

(±)-2-(lH-Indol-3-yl)-3-[l-(2-methoxy-3-dimethylaminopropyl)-7 methylthio-lH-indol-3-yl]-maleinimid;(±) -2- (1H-indol-3-yl) -3- [1- (2-methoxy-3-dimethylaminopropyl) -7-methylthio-1H-indol-3-yl] -maleimide;

(±)-2-(lH-Indol-3-yl)-3-[4,5-dimethoxy-l-(2-methoxy-3-0 dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;(±) -2- (1H-indol-3-yl) -3- [4,5-dimethoxy-1- (2-methoxy-3-dimethylaminopropyl) -1H-indol-3-yl] -maleimide;

(±)-2-(lH-Indol-3-yl)-3-[5,6-dimethoxy-l-(2-methoxy~3·- dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;(±) -2- (1H-indol-3-yl) -3- [5,6-dimethoxy-1- (2-methoxy-3-dimethylaminopropyl) -1H-indol-3-yl] -maleimide;

(±)-2-(lH-Indol-3-yl)-3-[6,7-dimethoxy-l-(2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl]-n>aleinimid;(±) -2- (1H-indol-3-yl) -3- [6,7-dimethoxy-1- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -n-α-imide;

(+)-2-[4-Acetylamino-l-(2-methoxy-3-dimethylaminopropyl/-lH-indol-3-y1]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [4-acetylamino-l- (2-methoxy-3-dimethylaminopropyl / -lH-indol-3-y1] -3- (lH-indol-3-yl) maleimide;

299970 -145- 299970 -145-

(+)-2-[5-Acetylamino-l-(2-methoxy-3-dimethylaminopropyl)-IH-indol-3-vl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [5-Acetylamino-l- (2-methoxy-3-dimethylaminopropyl) -IH-indol-3-vl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[6-Acetylamino-l-(2-methoxy-3-dimethylaminopropyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [6-acetylamino-l- (2-methoxy-3-dimethylaminopropyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[7-Acetylamino-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-2-yl]-3-(lH-indol-3~yl)-maleinimid;(+) - 2- [7-acetylamino-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-2-yl] -3- (lH-indol-3 ~ yl) maleimide;

(+)-2-[4-Amino-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [4-amino-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[5-Amino-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [5-amino-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[6-Amino-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3· yl]-3- (lH-indol-3-yl)-maleinimid;(+) - 2- [6-amino-1- (2-methoxy-3-dimethylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[7-Amino-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3· ylJ-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [7-amino-1- (2-methoxy-3-dimethylaminopropyl) -1H-indol-3-ylJ-3- (1H-indol-3-yl) -maleimide;

(+)-2-[4-Benzyloxy-l-(2-methoxy-3-dimethylaminopropyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [4-benzyloxy-l- (2-methoxy-3-dimethylaminopropyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[5-Berizyloxy-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [5-Berizyloxy-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

-2-[6-Benzyloxy-l-(2-methoxy-3-dimethylaminopropyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;-2- [6-benzyloxy-l- (2-methoxy-3-dimethylaminopropyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[7-Benzyloxy-l-(2-methox}-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [7-benzyloxy-l- (2-Methox} -3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[4-Brom-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3 yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [4-Bromo-1- (2-methoxy-3-dimethylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[5-Brom-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3 yl]-3-(lH-indol-3~yl)-maleinimid;(+) - 2- [5-Bromo-1- (2-methoxy-3-dimethylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

-146--146-

(+)-2-[6-Brom-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [6-bromo-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[7-Brom-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl] -3- (lH-indol-3-yl) -maleiniioid;(+) - 2- [7-Bromo-1- (2-methoxy-3-dimethylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleic acid;

(+)-2-[4-Chlor-l-(2-methoxy-3-diaethylaminopropyl)-lH-indol-3-.yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [4-chloro-l- (2-methoxy-3-diaethylaminopropyl) -lH-indol-3-.yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[5-Chlor-l-(2-methoxy-3-dimethylaminopropyI)-IK-indol-3-y1]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [5-chloro-l- (2-methoxy-3-dimethylaminopropyI) -IK-indol-3-y1] -3- (lH-indol-3-yl) maleimide;

(+)-2-[6-Chlor-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [6-chloro-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[7-Chlor-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [7-chloro-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[4-Fluor-l-(2-methoxy-3-dimethylaminopropy1)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [4-fluoro-l- (2-methoxy-3-dimethylaminopropy1) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[5-Fluor-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [5-fluoro-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[6-Fluor-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [6-fluoro-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[7-Fluor-l-(2-methoxy~3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [7-fluoro-l- (2-methoxy ~ 3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[4-Hydroxy-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol· 3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [4-Hydroxy-1- (2-methoxy-3-dimethylaminopropyl) -1H-indole-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[5-Hydroxy-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl] -',- (lH-indol-3-yl) -maleinimid;(+) - 2- [5-Hydroxy-1- (2-methoxy-3-dimethylaminopropyl) -1H-indol-3-yl] -, - (1H-indol-3-yl) -maleimide;

(+)-2-[6-Hydroxy-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-ylj-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [6-hydroxy-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-YLJ-3- (lH-indol-3-yl) maleimide;

-147--147-

( + ) -2-[7-Hydroxy-l- (2.-methoxy-3-diniethylaininoprc>pyl) -lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) -2- [7-Hydroxy-1- (2-methoxy-3-diniethyl-ininopropyl) -pH-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

( + ) -2-[4-Trifluormethyl-l-(2-methoxy-3-dimethylaininopropyl) -IH-indol-3-yl]-3-(lH-indol-3-yl)-nialeinimid;(+) -2- [4-trifluoromethyl-1- (2-methoxy-3-dimethylaminopropyl) -IH-indol-3-yl] -3- (1H-indol-3-yl) -ialeinimide;

( + ) -2-[5-TrifIuormethyl-l-(2-methoxy-3-dimethylaminopropyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) -2- [5-trifluoromethyl-1- (2-methoxy-3-dimethylaminopropyl) -IH-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[6-Trifluonnethyl-l-(2-methoxy-3-diniethylaininopro{iyl) -IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [6-trifluoro-ethyl-1- (2-methoxy-3-diniethyl-in-n-ethyl-i-H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[7-Trifluormethyl-l-(2-methoxy-3-dimethylaminopropyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) - 2- [7-trifluoromethyl-l- (2-methoxy-3-dimethylaminopropyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-(lH-Indol-3-yl)-3-[4-methoxy-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;(+) - 2- (lH-indol-3-yl) -3- [4-methoxy-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide;

(+)-2~(lH-Indol-3-yl)-3-[5-methoxy-l-(2-methox/-3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;(+) - 2 ~ (lH-Indol-3-yl) -3- [5-methoxy-l- (2-Methox / -3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide;

(+)-2-(lH-Indol-3-yl)-3-[6-methoxy-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;(+) - 2- (lH-indol-3-yl) -3- [6-methoxy-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide;

-2-(lH-Indol-3-yl)-3-[7-methoxy-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;-2- (lH-indol-3-yl) -3- [7-methoxy-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide;

(+)-2-(lH-Indol-3-y1)-3-[1-(2-methoxy-3-dimethylaminopropyl) 4,5-methylendioxy~lH-indol-3-yl]-maleinimid;(+) - 2- (1H-indol-3-yl) -3- [1- (2-methoxy-3-dimethylaminopropyl) 4,5-methylenedioxy-1H-indol-3-yl] -maleimide;

-2-(lH-Indol-3-yl)-3-[l-(2-methoxy-3-dimethylaminopropyl) 5,6-methylendioxy-lH-indol-3-yl]-maleinimid;-2- (1H-indol-3-yl) -3- [1- (2-methoxy-3-dimethylaminopropyl) -5,6-methylenedioxy-1H-indol-3-yl] -maleimide;

-3-[l-(2-methoxy-3-dimethylaminopropyl)-6,7-methylendioxy-lH-indol-3-yl]-maleinimid;-3- [l- (2-methoxy-3-dimethylaminopropyl) -6,7-methylenedioxy-lH-indol-3-yl] -maleimide;

(+)-2-(lH-Indol-3-yl)-3-tl-(2-methoxy-3-dimethylaminopropyl)-4-methyl-lH-indol-3-yl]-maleinimid;(+) - 2- (lH-indol-3-yl) -3-tl (2-methoxy-3-dimethylaminopropyl) -4-methyl-lH-indol-3-yl] -maleimide;

-148--148-

-2-(lH-Indol-3-yl)-3-[l-(2-methoxy-3-dimethylaminopropyl)-5-methyl-lH-indol-3-yl]-maleinimid;-2- (lH-indol-3-yl) -3- [l- (2-methoxy-3-dimethylaminopropyl) -5-methyl-lH-indol-3-yl] -maleimide;

(+)-2-(lH-Indol-3-yl)-3-[l-(2-methoxy-3-dimethylaminopropyl)-6-methyl-lH-indol-3-yl]-maleinimid;(+) - 2- (lH-indol-3-yl) -3- [l- (2-methoxy-3-dimethylaminopropyl) -6-methyl-lH-indol-3-yl] -maleimide;

(+)-2-(lH-Indcl-3-yl)-3-[l-(2-methoxy-3-dimethylaminopropyl)-7-methyl-lH-indol-3-yl]-maleinimid;(+) - 2- (lH-Indcl-3-yl) -3- [l- (2-methoxy-3-dimethylaminopropyl) -7-methyl-lH-indol-3-yl] -maleimide;

(+)-2-(lH-Indol-3-yl)-3-[l-(2-methoxy-3-dimethylaminopropyl)-4-nitro-lH-indol-3-yl]-maleinimid;(+) - 2- (lH-indol-3-yl) -3- [l- (2-methoxy-3-dimethylaminopropyl) -4-nitro-lH-indol-3-yl] -maleimide;

(+)-2-(lH-Indol-3-yl)-3-[l-(2-methoxy-3-dimethylaminopropyl)-5-nitro-lH-indol-3-yl]-inaleinimid;(+) - 2- (lH-indol-3-yl) -3- [l- (2-methoxy-3-dimethylaminopropyl) -5-nitro-lH-indol-3-yl] -inaleinimid;

(+)-2-(lH-Indol-3-yl)-3-[l-(2-methoxy-3-dimethylaminopropyl)-6-nitro-lH-indol-3-yl]-roaleinimid;(+) - 2- (lH-indol-3-yl) -3- [l- (2-methoxy-3-dimethylaminopropyl) -6-nitro-lH-indol-3-yl] -roaleinimid;

(+)-2-(lH-Indol-3-yl)-3-[l-(2-methoxy-3-dimethylaminopropyl)-7-nitro-lH-indol-3-yl]-maleinimid;(+) - 2- (lH-indol-3-yl) -3- [l- (2-methoxy-3-dimethylaminopropyl) -7-nitro-lH-indol-3-yl] -maleimide;

(+ )-2-(lH-Indol-3-yl)-3-[l-(2-methoxy-3-dimethylaminopropy1)-4 methylthio-lH-indol-3-yl]-maleinimid;( +) - 2- (1H-Indol-3-yl) -3- [1- (2-methoxy-3-dimethylaminopropyl) -4-methylthio-1H-indol-3-yl] -maleimide;

(+)-2-(lH-Indol-3-yl)-3-[l-(2-methoxy-3-dimethylaminopropyl)-5-methylthio-lH-indol-3-yl]-maleinimid;(+) - 2- (lH-indol-3-yl) -3- [l- (2-methoxy-3-dimethylaminopropyl) -5-methylthio-lH-indol-3-yl] -maleimide;

(+)-2-(lH-Indol-3-yl)-3-[l-(2-methoxy-3-dimethylaminopropyl)-6-methyithio-lH-indol-3-yl]-maleinimid;(+) - 2- (lH-indol-3-yl) -3- [l- (2-methoxy-3-dimethylaminopropyl) -6-methylthio-lH-indol-3-yl] -maleimide;

( + )-2-(lH-Indol-3-yl)-3-[l-(2-methoxy-3-dimethylaminopropy1)-7-methylthio-lH-indol-3-yl]-maleinimid;(+) -2- (1H-Indol-3-yl) -3- [1- (2-methoxy-3-dimethylaminopropyl) -7-methylthio-1H-indol-3-yl] -maleimide;

(+)-2-(lH-Indol-3-yl)-3-[4_;5-dimethoxy-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;(+) - 2- (1H-indol-3-yl) -3- [4 _; 5-dimethoxy-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide;

(+)-2-(lH-Indol-3-yl)-3-[5,6-dimethoxy-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;(+) - 2- (lH-indol-3-yl) -3- [5,6-dimethoxy-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide;

-149--149-

(+)-2-(lH-Tndol-3-yl)-3-[6,7-dimethoxy-l-(2-methoxy-3-dimethylaininopropyl)-lH-indol-3-yl]-maleinimid;(+) - 2- (lH-Tndol-3-yl) -3- [6,7-dimethoxy-l- (2-methoxy-3-dimethylaininopropyl) -lH-indol-3-yl] -maleimide;

(-)-2-[4-Acetylamino-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [4-acetylamino-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[5-Acetylamino-l-(2-methoxy-3-dimethylaminopropyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [5-Acetylamino-l- (2-methoxy-3-dimethylaminopropyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-) -2-[6-Acetylamino-l-(2-methoxy-3-ditnethylaminopropyl) -IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid; (-) -2- [6-Acetylamino-1- (2-methoxy-3-dinethylaminopropyl) -IH-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(-)-2-[7-Acetylamino-1-(2-methoxy-3-dimethylaminopropy1)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [7-acetylamino-1- (2-methoxy-3-dimethylaminopropy1) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[4-Amino-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3· yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [4-Amino-1- (2-methoxy-3-dimethylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(-)-2-[5-Amino-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [5-amino-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-l6-Amino-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2-l6-amino-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[7-Amino-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [7-amino-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[4-Benzyloxy-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [4-benzyloxy-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[5-Benzyloxy-l-(2-methoxy-3-dimethylaminopropyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [5-benzyloxy-l- (2-methoxy-3-dimethylaminopropyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[6-Benzyloxy-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [6-benzyloxy-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-L7-Benzyloxy-l-(2-methoxy-3-dimethylaminopropyl)-IH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;maleimide 2-L7-benzyloxy-l- (2-methoxy-3-dimethylaminopropyl) -IH-indol-3-yl] -3- (IH-indol-3-yl) - (-);

-150--150-

(-) -2-[4-Brom-l- (;j-methoxy-3-dimethyIaminopropyl) -lH-ii.dol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(-) -2- [4-Bromo-1- (1-methoxy-3-dimethylaminopropyl) -lH-ii.dol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(-) -2-[5-Brom-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3~(lH-indol-3-yl)-maleinimid;(-) -2- [5-Bromo-1- (2-methoxy-3-dimethylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(-) -2-[6-Broir-l-(2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl]-3-(lH-indol-3-yl) -inaleinimid;(-) -2- [6-Broir-1- (2-methoxy-3-dimethylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(-)-2-[7-Brom-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-malfeinimid;(-) - 2- [7-bromo-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) -malfeinimid;

(-) -2-[4--Chlor-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) -2- [4-chloro-1- (2-methoxy-3-dimethylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(-)-2-[5-Chlor-l-(2-methoxy-3-dimethylaminopropyl)-lH~indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [5-chloro-l- (2-methoxy-3-dimethylaminopropyl) -lH ~ indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[6-Chlor-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [6-chloro-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[7-Chlor-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [7-chloro-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

{-)-2-[4-Fluor-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;{-) - 2- [4-fluoro-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-) -2-[5-Fluor-l- (2-methoxy-3-dimf;thylaminopropyl)-lH-indol"3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) -2- [5-Fluoro-1- (2-methoxy-3-dimethyl-aminopropyl) -H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(-)-2-[6-Fluor-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indul-3-yl)-maleinimid;(-) - 2- [6-fluoro-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indul-3-yl) maleimide;

(-)-2-[7-Fluor-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [7-fluoro-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2~[4-Hydroxy-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2 ~ [4-hydroxy-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

-151--151-

(-)-2-[5-Hydroxy-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [5-hydroxy-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[6-Hydroxy-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH~indol-3-yl)-maleinimid;(-) - 2- [6-hydroxy-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH ~ indol-3-yl) maleimide;

(-)-2-[7-Hydroxy-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-. 3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [7-hydroxy-l- (2-methoxy-3-dimethylaminopropyl) -lH-indole. 3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[4-Trifluormethyl-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [4-trifluoromethyl-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[5-Trifluormethy1-1-(2-methoxy-3-dimethylaminopropyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [5-Trifluormethy1-1- (2-methoxy-3-dimethylaminopropyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[6-Trifluormethy1-1-(2-methoxy-3-dimethylaminopropyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [6-Trifluormethy1-1- (2-methoxy-3-dimethylaminopropyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-[7-trifluormethyl-l-(2-methoxy-3-dimethylaminopropyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(-) - 2- [7-trifluoromethyl-l- (2-methoxy-3-dimethylaminopropyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-)-2-(lH-Indol-3-yl)-3-[4-methoxy-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;(-) - 2- (lH-indol-3-yl) -3- [4-methoxy-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide;

(-)-2-(lH-Indol-3-yl)-3-i;f-methoxy-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;(-) - 2- (lH-indol-3-yl) -3-i; f-methoxy-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide;

(-)-2-(lH-Indol-3-yl)-3-[6-methoxy-l-(2-methoxy-3-0 diiiethylaminopropyl) -lH-indol-3-yl ] -maleinimid ;(-) - 2- (1H-Indol-3-yl) -3- [6-methoxy-1- (2-methoxy-3-0-diethylaminopropyl) -1H-indol-3-yl] -maleimide;

(-)-2-(lH-Indol-:ⁱ-yl)-3-[7-methoxy-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;(-) - 2- (1H-indol- ⁱ -yl) -3- [7-methoxy-1- (2-methoxy-3-dimethylaminopropyl) -1H-indol-3-yl] -maleimide;

(-)-2-(lH-Indol-3-yl)-3-[l-(2-methoxy-3-dimethylaminopropyl)-4,5-nethylendicxy-lH-indol-3-yl]-maleinimid;(-) - 2- (lH-indol-3-yl) -3- [l- (2-methoxy-3-dimethylaminopropyl) -4,5-nethylendicxy-lH-indol-3-yl] -maleimide;

(-)-2-(lH-Indol-3-yl)-3-[l-(2-methoxy-3-dimethylaminopropyl)-5, 6-methylend:.oxy-lH-indol-3-yl] -maleinimid;(-) - 2- (1H-Indol-3-yl) -3- [1- (2-methoxy-3-dimethylaminopropyl) -5,6-methylene: .oxy-1H-indol-3-yl] -maleimide ;

(-)-2-(lH-Indol-3-yl)-3-[l-(2-methoxy-3-dimethylaminopropyl)-6,7-methylendioxy-lH-indol-3-yl]-maleinimid;(-) - 2- (lH-indol-3-yl) -3- [l- (2-methoxy-3-dimethylaminopropyl) -6,7-methylenedioxy-lH-indol-3-yl] -maleimide;

(-)-2-(lH-Indol-3-yl)-3-[l-(2-raethoxy-3-dimethylaminopropyl)-4-methyl-lH-indol-3-yl]-maleiniin:.d;(-) - 2- (lH-indol-3-yl) -3- [l- (2-raethoxy-3-dimethylaminopropyl) -4-methyl-lH-indol-3-yl] -maleiniin: .d;

(-)-2-(lH-Indol-3-yl)-3-[l-(2-methoxy-3-dimethylaminopropyl)-5- -methyl-lH-indol-3-yl]-maleinimid;(-) - 2- (1H-Indol-3-yl) -3- [1- (2-methoxy-3-dimethylaminopropyl) -5-methyl-1H-indol-3-yl] -maleimide;

(-)-2-(lH-Indol-3-yl)-3-[l-(2-methoxy-3-dimethylaminopropyl)-6-methyl-IH-indol-3-yl]-maleinimid;(-) - 2- (lH-indol-3-yl) -3- [l- (2-methoxy-3-dimethylaminopropyl) -6-methyl-IH-indol-3-yl] -maleimide;

(-)-2-(lH-Indol-3-yl)-3-[l-(2-methoxy-3-dimethylarainopropyl)-7-methyl-lH-indol-3-yl]-maleinimid;(-) - 2- (lH-indol-3-yl) -3- [l- (2-methoxy-3-dimethylarainopropyl) -7-methyl-lH-indol-3-yl] -maleimide;

-3-[l-(2-methoxy-3-dimethylaminopropyl)-4-nitro-lH-indol-3-yl]-maleinimid;-3- [l- (2-methoxy-3-dimethylaminopropyl) -4-nitro-lH-indol-3-yl] -maleimide;

(-)-2-(lH-Indol-3-yl)-3-[l-(2-methoxy-3-dimethylaminopropyl)-5-nitro-lH-indol-3-yl]-maleinimid;(-) - 2- (lH-indol-3-yl) -3- [l- (2-methoxy-3-dimethylaminopropyl) -5-nitro-lH-indol-3-yl] -maleimide;

(-)-2-(lH-Indol-3-yl)-3-[l-(2-methoxy-3-dimethylaminopropyl)-6-nitro-lH-indol-3-yl]-maleinimid;(-) - 2- (lH-indol-3-yl) -3- [l- (2-methoxy-3-dimethylaminopropyl) -6-nitro-lH-indol-3-yl] -maleimide;

(-)-2-(lH-Indol-3-yl)-3~ri-(2-methoxy-3-dimethylaminopropyl)-7-nitro-lK-indol-3-yl]-maieinimid;(-) - 2- (lH-indol-3-yl) -3 ~ ri- (2-methoxy-3-dimethylaminopropyl) -7-nitro-lK-indol-3-yl] -maieinimid;

(-)-2-(lH-T.ndol-3-yi)-3-[l--(2-methoxy-3-dimethylaminopropyl)-4-methylthio-lH-indol-3-yl]-maleinimid;(-) - 2- (lH-T.ndol-3-yl) -3- [l - (2-methoxy-3-dimethylaminopropyl) -4-methylthio-lH-indol-3-yl] -maleimide;

(-)-2-(lH-Indol-3-yl)-3-ri-(2-methcxy-3-dimethylaminopropyl)-5-methylthiO"lH-indol-3-yl]-maleinimid;(-) - 2- (lH-indol-3-yl) -3-ri- (2-methcxy-3-dimethylaminopropyl) -5-methylthio 'lH-indol-3-yl] -maleimide;

(-)-2-(lH-Indol-3-yl)-3-[l-(2-methoxy-3-dimethylaminopropyl)-6-methylthio-lH-indol-3-yl]-maleinimid;(-) - 2- (lH-indol-3-yl) -3- [l- (2-methoxy-3-dimethylaminopropyl) -6-methylthio-lH-indol-3-yl] -maleimide;

(-)-2-(lH-Indol-3-yl)-3-[l-(2-methoxy-3-dimethylaminopropyl)-7-methylthio-lH-indol-3-yl]-maleinimid;(-) - 2- (lH-indol-3-yl) -3- [l- (2-methoxy-3-dimethylaminopropyl) -7-methylthio-lH-indol-3-yl] -maleimide;

-₁₅₃_- ₁₅₃ _

(-)-2-(lH-Indol-3-yl)-3-[4,5-dimethoxy-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;(-) - 2- (lH-indol-3-yl) -3- [4,5-dimethoxy-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide;

(-)-2-(lH-Indol-3-yl)-3-[5,6-dimethoxy-l-(2-methoxy-3-dimethylaminopropy1)-lH-indol-3-yl]-maleinimid;(-) - 2- (lH-indol-3-yl) -3- [5,6-dimethoxy-l- (2-methoxy-3-dimethylaminopropy1) -lH-indol-3-yl] -maleimide;

(-)-2-(lH-Indol-3-yl)-3-[6,7-dimethoxy-l-(2-methoxy-3-.dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;(-) - 2- (lH-indol-3-yl) -3- [6,7-dimethoxy-l- (2-methoxy-3-.dimethylaminopropyl) -lH-indol-3-yl] -maleimide;

2-[4-Acetylamino-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [4-acetylamino-l- (2-dimethylaminoethyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[5-Acetylamino-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [5-Acetylamino-l- (2-dimethylaminoethyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[6-Acetylamino-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [6-acetylamino-l- (2-dimethylaminoethyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[7-Acetylamino-l-(2-dimethylaminoethyl)-iH-indol-3-yl]-3-(lH-indol-3-yl)-maleiniuid;2- [7-acetylamino-l- (2-dimethylaminoethyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) -maleiniuid;

2-[4-Amino-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-3-(lH-indol" 3-yl)-maleinimid;2- [4-Amino-1- (2-dimethylaminoethyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[5-Amino-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [5-amino-l- (2-dimethylaminoethyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[6-Amino-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-3-(lH-indol" 3-yl)-maleinimid;2- [6-Amino-1- (2-dimethylaminoethyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[7-Amino-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [7-amino-l- (2-dimethylaminoethyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[4-Benzyloxy-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [4-benzyloxy-l- (2-dimethylaminoethyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

5 2-[5-Benzyloxy-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;5 2- [5-Benzyloxy-1- (2-dimethylaminoethyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[6-Benzyloxy-l-(2-dimethylaminoethyi)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [6-benzyloxy-l- (2-dimethylaminoethyi) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[7-Benzyloxy-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [7-benzyloxy-l- (2-dimethylaminoethyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[4-Brom-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [4-bromo-l- (2-dimethylaminoethyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[5-Brom-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [5-bromo-l- (2-dimethylaminoethyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[6-Brom-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [6-bromo-l- (2-dimethylaminoethyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[7-Brom-l-(2-dimethylami noethyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [7-bromo-1- (2-dimethylaminoethyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[4-Chlor-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [4-chloro-l- (2-dimethylaminoethyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[5-Chlor-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [5-chloro-l- (2-dimethylaminoethyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[6-Chlor-l-(2-dimethylaminoethyl)-lH-.\ndol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [6-chloro-l- (2-dimethylaminoethyl) -lH - \ ndol-3-yl.] -3- (lH-indol-3-yl) maleimide;

2-[7-Chlor-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-3-(lH-indol-0 3-y1)-maleinimid;2- [7-chloro-1- (2-dimethylaminoethyl) -1H-indol-3-yl] -3- (1H-indol-0 3-yl) -maleimide;

2-[4-Fluor-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-3-(.lH-indol-3-yl)-maleinimid;2- [4-fluoro-l- (2-dimethylaminoethyl) -lH-indol-3-yl] -3 - (lH-indol-3-yl.) Maleimide;

2-[5-Fluor-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [5-fluoro-l- (2-dimethylaminoethyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[6-Fluor-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [6-fluoro-l- (2-dimethylaminoethyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

_₁₅₅__ ₁₅₅ _

2-[7-Fluor-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [7-fluoro-l- (2-dimethylaminoethyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2- [ 4-Hydroxy-l- (2-dimethylamii.oethyl) -lH-indol-3-yl ] -3- (IH-indol-3-yl)-maleinimid;2- [4-hydroxy-1- (2-dimethylaminoethyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[5-Hydroxy-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-3-(IH-• indol-3-yl)-maleinimid;2- [5-hydroxy-1- (2-dimethylaminoethyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[6-Hydroxy-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [6-hydroxy-l- (2-dimethylaminoethyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-(7-Hydroxy-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- (7-hydroxy-l- (2-dimethylaminoethyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[4-Trifluormethyl-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [4-trifluoromethyl-l- (2-dimethylaminoethyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-(5-Trifluormethyl-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- (5-trifluoromethyl-l- (2-dimethylaminoethyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[6-Trifluormethyl-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [6-trifluoromethyl-l- (2-dimethylaminoethyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[7-Trifluormethyl-l-(2-dimethylaminoethyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;maleimide 2- [7-trifluoromethyl-l- (2-dimethylaminoethyl) -IH-indol-3-yl] -3- (lH-indol-3-yl);

2-(lH-Indol-3-yl)-3-[4-methoxy-l-(2-dimethylaminoethyl)-IH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [4-methoxy-l- (2-dimethylaminoethyl) -IH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[5-methoxy-l-(2-dimethylaminoethyl)-IH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [5-methoxy-l- (2-dimethylaminoethyl) -IH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[6-methoxy-l-(2-dimethylaminoethyl)-IH-indoi-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [6-methoxy-l- (2-dimethylaminoethyl) -IH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[7-methoxy-l-(2-dimethylaminoethyl)-IH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [7-methoxy-l- (2-dimethylaminoethyl) -IH-indol-3-yl] -maleimide;

_₁₅₆__ ₁₅₆ _

2~(lH-Indol-3-yl)-3-[l~(2-dimethylaminoethyl)-4,5-methylendioxy-lH-indol-3-yl]-maleinimid;2 ~ (lH-Indol-3-yl) -3- [l ~ (2-dimethylaminoethyl) -4,5-methylenedioxy-lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[1-(2-dimethylaminoethyl)-5,6-methylendioxy-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [1- (2-dimethylaminoethyl) -5,6-methylenedioxy-lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[l-(2-dimethylaminoethyl)-6_/7-methylendioxy-lH-indol-3-yl]-maleinimid;2- (1H-indol-3-yl) -3- [1- (2-dimethylamino-ethyl) -6 _/ 7-methylenedioxy-1H-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[4-methyl-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [4-methyl-l- (2-dimethylaminoethyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[5-methyl-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [5-methyl-l- (2-dimethylaminoethyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-t6-Tnethyl-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3-t6-Tnethyl-l- (2-dimethylaminoethyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[7-methyl-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [7-methyl-l- (2-dimethylaminoethyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[l-(2-dimethylaminoethyl)-4-nitro-lH-indol-3-y1]-maleinimid;2- (lH-indol-3-yl) -3- [l- (2-dimethylaminoethyl) -4-nitro-lH-indol-3-y1] maleimide;

2-(lH-Indol-3-yl)-3-[l-(2-dimethylaminoethyl)-5-nitro-lH-indol-3-y1]-maleinimid;2- (lH-indol-3-yl) -3- [l- (2-dimethylaminoethyl) -5-nitro-lH-indol-3-y1] maleimide;

2-(lH-Indol-3-yl)-3-[l-(2-dimethylaminoethyl)-6-nitro-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [l- (2-dimethylaminoethyl) -6-nitro-lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)»3-[l-(2-dimethylaminoethyl)-7-nitro-lH-indol-3-yl] -maleinimid;2- (1H-indol-3-yl) -3- [1- (2-dimethylaminoethyl) -7-nitro-1H-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[l-(2-dimethylaminoethyl)-4-Äethylthio-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [l- (2-dimethylaminoethyl) -4-Äethylthio-lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[l-(2-dimethylaminoethyl)-5-methylthio-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [l- (2-dimethylaminoethyl) -5-methylthio-lH-indol-3-yl] -maleimide;

_₁₅₇._ ₁₅₇ .

2-(lH-Irdol-3-y].)-3-[l-(2-diioethylaminoethyl)-6--iaethylthio-lH-indol-3-yl]-maleinimid;2- (. LH-Irdol-3-y]) - 3- [l- (2-diioethylaminoethyl) -6 - iaethylthio-lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[l-(2-dimethylaminoethyl)-7-methylthio-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [l- (2-dimethylaminoethyl) -7-methylthio-lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[4,5-dimethoxy-l-(2-dimethylaminoethyl)-IH-•indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [4,5-dimethoxy-l- (2-dimethylaminoethyl) -IH- • indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[5,6-dimethoxy-l-(2-dimethylaminoethyl)-IH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [5,6-dimethoxy-l- (2-dimethylaminoethyl) -IH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[6,7-dimethoxy-l-(2-dimethylaminoethyl)-IH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [6,7-dimethoxy-l- (2-dimethylaminoethyl) -IH-indol-3-yl] -maleimide;

2-[4-Acetylamino-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [4-acetylamino-l- (3-dimethylaminopropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[5-Acetylamino-l-(3-dimethylaminopropyl)-2.H-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [5-Acetylamino-l- (3-dimethylaminopropyl) -2.H-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[6-Acetylamino-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [6-acetylamino-l- (3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[7-Acetylamino-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;maleimide 2- [7-acetylamino-l- (3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl);

2-[4-Amino-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [4-amino-l- (3-dimethylaminopropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[5-Amino-l"(3-dimethylaminopropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [5-amino-l "(3-dimethylaminopropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[6-Aadno-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [6-Aadno-l- (3-dimethylaminopropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[7-Amino-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;maleimide 2- [7-amino-l- (3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl);

_₁₅₈__ ₁₅₈ _

2-[4-Benzyloxy-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [4-benzyloxy-l- (3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[5-Benzyloxy-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indo.\-3-yl) -maleinimid;2- [5-Benzyloxy-1- (3-dimethylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[6-Benzyloxy-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-•indol-3-yl)-maleinimid;2- [6-benzyloxy-l- (3-dimethylaminopropyl) -lH-indol-3-yl] -3- (LH • indol-3-yl) maleimide;

2-[7-Benzyloxy-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;maleimide 2- [7-benzyloxy-l- (3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl);

2-[4-&rom-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [4- & rom-l- (3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[5-Brom-l--(3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [5-bromo-l - (3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-Γ 6-Brom-l-(3-dimethylaminopropyi)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2-Γ 6-bromo-1- (3-dimethylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[7-Brom-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;maleimide 2- [7-bromo-l- (3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl);

2-[4-Chlor-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [4-chloro-l- (3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[5-Chlor-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [5-chloro-l- (3-dimethylaminopropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[6-Chlor-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [6-chloro-l- (3-dimethylaminopropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[7-Chlor-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [7-chloro-l- (3-dimethylaminopropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[4-Fluor-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH~ indol-3-yl)-maleinimid;2- [4-fluoro-1- (3-dimethylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[6-Fluor-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [6-fluoro-l- (3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[7-Fluor-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [7-fluoro-l- (3-dimethylaminopropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[4-Hydroxy-l~(3~dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-.indol-3-yl)-maleinimid;2- [4-hydroxy-l ~ (3 ~ dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-.indol-3-yl) maleimide;

2-[5-Hydroxy-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [5-hydroxy-l- (3-dimethylaminopropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[6-Hydroxy-l-(3-dimethylaminopropyj.)-lH-indol-3-yl]'-3-(lH-indol-3-yl)-maleinimid;2- [6-hydroxy-l- (. 3-dimethylaminopropyj) - lH-indol-3-yl] '- 3- (lH-indol-3-yl) maleimide;

2-[7-Hydroxy-l-(J-dimethylaminopropyl)-lH-indoi-3-yl]-3-(lH-indoi-3-yl)-maleinimid;2- [7-hydroxy-l- (J-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[4-Trifluormethyl-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [4-trifluoromethyl-l- (3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[5-Tri::iuormethyl-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [5-tri :: iuormethyl-l- (3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[6-Trifluormethyl-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [6-trifluoromethyl-l- (3-dimethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[7-Trifluormethyl-l-(3-diinethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [7-trifluoromethyl-l- (3-diinethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-(lH-Indol-3-yl)--3-[4^e-ChOXy-I-(3-dimethylaminopropyl)-IH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) - 3- [4 ^ e-ChOXy-I- (3-dimethylaminopropyl) -IH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[6-methoxy-l-(T-dim«thylaminopropyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [6-methoxy-l- (T-dim "thylaminopropyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indoi-3-yl)-3-[7-methoxy-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [7-methoxy-l- (3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide;

-160--160-

2-(lH-Indol-3-yl)-3-[1-(3-dimethylaminopropyi)-4,5-methylendioxy-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [1- (3-dimethylaminopropyi) -4,5-methylenedioxy-lH-indol-3-yl] -maleimide;

2-(lH-Indol~3-yl)-3-[l-(3-dimethylamr.opropyl)--5,6-methylendioxy-lH-indol-3-yl]-mal*?..ini!Jiid;2- (lH-indole ~ 3-yl) -3- [l- (3-dimethylamr.opropyl) - 5,6-methylenedioxy-lH-indole-3-yl] times * .. ini Jiid?;!

2-(lH-Indol-3-yl)-3-[l-(3-diiuethylaminopropyl)-6,7-. methy.lendioxy-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [l- (3-diiuethylaminopropyl) -6,7. methy.lendioxy-lH-indol-3-yl] -maleimide;

2-(iH-Indoi-3-yl)-3-[4-methyl-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;2- (iH-indol-3-yl) -3- [4-methyl-l- (3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[5-n5sthyl"l-(3=diinethylainiriopropyl)-lH-indol-3-yl]-maleinim.id;2- (lH-indol-3-yl) -3- [5-n5sthyl "l- (3 = diinethylainiriopropyl) -lH-indol-3-yl] -maleinim.id;

2-(lH-Indol-3-yl)-3-[6-methyl-l-(3-dimethylaminopropyl)-lK-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [6-methyl-l- (3-dimethylaminopropyl) -LK-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[7-methyl-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [7-methyl-l- (3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide;

;>-(lH-Indol-3-yl)-3-[l-(3-dimethylaminopropyl)-4-nitro-lH-i.ndol-3 -yl ] -maleinimid;; - (1H-indol-3-yl) -3- [1- (3-dimethylaminopropyl) -4-nitro-1H-i-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[l-(3-dimethylaminopropyl)-5-nitro-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [l- (3-dimethylaminopropyl) -5-nitro-lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[1-(3-dimethylaminopropyl)-6-nitro-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [1- (3-dimethylaminopropyl) -6-nitro-lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[l-(3-dimethylaminopropyl)-7=nitro-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [l- (3-dimethylaminopropyl) -7 = nitro-lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[1-(3-dimethylaminopropyl)-4-methylthio-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [1- (3-dimethylaminopropyl) -4-methylthio-lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[1-l3-dimethylaminopropyl)-5-methylthio-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [1-l3-dimethylaminopropyl) -5-methylthio-lH-indol-3-yl] -maleimide;

-161--161-

2-(lH-Indol-3-yl)-3-[l-(3-dimethylami)iopi-opyl)-6-methyli:nio-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [l- (3-dimethylamino) iopi-opyl) -6-methyli: nio-lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[l-(3-d;.wethylaminopropyl)-7-methylthio-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [l- (3-d; .wethylaminopropyl) -7-methylthio-lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[4,5-dimsthoxy-l-(3-dim'ithylaminopropy.l.)-.lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [(. 3-dim'ithylaminopropy.l). 4,5-dimsthoxy-l - lH-indol-3-yl] -maleimide;

2-(i.H-Indol-3-yl) -3-[5,6-dimethoxy-l-(3-dimethylaminopropyl) lH-indol-3-yl]-maleiniraid;2- (i.H-indol-3-yl) -3- [5,6-dimethoxy-1- (3-dimethylaminopropyl) -1H-indol-3-yl] -maleiniride;

2-(lH-Indol-3-yl)-3-r6_;7-dimethoxy-l-(3-dLmethylaaiino"propyl)-lH-indol-3-yl]-maleinimid;2- (1H-indol-3-yl) -3-r6 _; 7-dimethoxy-l- (3-dLmethylaaiino "propyl) -lH-indol-3-yl] -maleimide;

2-[4-Acetylamino-l-(3-methylaminopropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [4-acetylamino-l- (3-methylaminopropyl) -lH-indol-3-yl] -maleimide -3- (IH-indol-3-yl);

2-[5-Acetylamino-l-(3-methylaminopropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleiniraid;2- [5-Acetylamino-l- (3-methylaminopropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) -maleiniraid;

2-[6-Acetylamino-l-(3-methylaminopropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [6-acetylamino-l- (3-methylaminopropyl) -lH-indol-3-yl] -maleimide -3- (IH-indol-3-yl);

2-[7-Acetylamino-l-(3-methylaminopropyl)-lH-indol-3-ylj-3-(IH-indol-3-yl)-maleinimid;2- [7-acetylamino-l- (3-methylaminopropyl) -lH-indol-3-YLJ-3- (IH-indol-3-yl) maleimide;

2-[4-Amino-l-(3-methylaminopropyl)-lH-inclol-3-yl]-3-(lH-indol-3-y1)-maleinimid;2- [4-amino-l- (3-methylaminopropyl) -lH-inclol-3-yl] -maleimide -3- (lH-indol-3-y1);

2-[5-Amino-l-(3-methylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [5-Amino-l- (3-methylaminopropyl) -lH-indol-3-yl] -maleimide -3- (lH-indol-3-yl);

2-(6-Amino-l-(3-methylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- (6-amino-l- (3-methylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2- [7-Amino-l- (3-methylaminopropyl) -lH-inclol-3-yl] -3- (lH-indol-3-yl)-maleinimid;2- [7-amino-1- (3-methylaminopropyl) -1H-inclol-3-yl] -3- (1H-indol-3-yl) -maleimide;

-162--162-

2-[4-Benzyloxy--l-( 3-methylaminopropyl )-iH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [4-Benzyloxy-1- (3-methylaminopropyl) -iH-indol-3-yl] -3- (IH-indol-3-yl) -maleimide;

2-[5-Benzyloxy-i-(3-methylaminopropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [5-benzyloxy-i- (3-methylaminopropyl) -lH-indol-3-yl] -maleimide -3- (IH-indol-3-yl);

2-[6-Benzyloxy-l-(3-methylaminopropyl)-lH-indol-3-yl]-3-(IH- indol-3-yl)-maleinimid;2- [6-Benzyloxy-1- (3-methylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[7-Benzyloxy-l-(3-methylaminopropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [7-benzyloxy-l- (3-methylaminopropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2- i'4-Brom-l-( 3-methylaminopropyl )-lH-indol-3-yl] -3- (lH-indol-3-y1)-maleinimid;2-i'4-bromo-1- (3-methylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[5-Brom-l-(3-methylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3· yl)-maleinimid;2- [5-bromo-1- (3-methylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[6-Brom-l-(3~methylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3· yl)-maleinimid;2- [6-bromo-1- (3-methylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[7~Brom-l-(3-methylaminopropy]_r)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [7 ~ bromo-l- (3-methylaminopropy] _r) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[4-Chlor-l-(3-methylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid; 2- [4-chloro-1- (3-methylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[5-Chlor-l-(3-methylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [5-chloro-l- (3-methylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-Γ 6-Chlot-l-(3-methylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2-Γ 6-chloro-1- (3-methylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[7-Chlor-l-(3-methylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleiniraid;2- [7-chloro-l- (3-methylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) -maleiniraid;

2-[4-Fluor-l-(3-methylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [4-fluoro-l- (3-methylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[5-Fluor-l-(3-methylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [5-fluoro-l- (3-methylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[6-Fluor-l-(3-methylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-.> yl)-maleinimid;2- [6-fluoro-1- (3-methylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-.-Yl) -maleimide;

2-[7-Fluor-l-(3-methylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-. 3-yl)-maleiniaid;2- [7-Fluoro-1- (3-methylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-.3-yl) -maleic acid;

2-[4-Hydroxy-l-(3-methylaminopropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [4-hydroxy-l- (3-methylaminopropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[5-Hydroxy-l-(3-methylaminopropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [5-hydroxy-l- (3-methylaminopropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[6-Hydroxy-l-(3-methylaminopropyl)-lH-indol-3-yl] -3-(1H-indol-3-yl)-maleinioid;2- [6-hydroxy-1- (3-methylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleinioid;

2-[7-Hydroxy-l-(3-methylaminopropyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [7-hydroxy-l- (3-methylaminopropyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[4-Trifluormethyl-l-(3-methylaaiinopropyl)-lH-indol-3-yl]-3-(lH-indol-3=yl)-maleinimid;2- [4-trifluoromethyl-l- (3-methylaaiinopropyl) -lH-indol-3-yl] -3- (lH-indol-3 = yl) maleimide;

2-[5-Trifluormethyl-l-"( 3-methylaminopropyl )-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [5-trifluoromethyl-1- (3-methylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[6-Trifluormethyl-l-(3-methylaminopropyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [6-trifluoromethyl-l- (3-methylaminopropyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[7-Trifluormethyl-l-(3-methylaminopropyl)-lH-indol-3-yl]-3-(lH~indol-3-yl)-naleinimid;2- [7-trifluoromethyl-l- (3-methylaminopropyl) -lH-indol-3-yl] -3- (lH ~ indol-3-yl) -naleinimid;

2-(lH-Indol-3-yl)-3-[4-methoxy-l-(3-methylaminopropyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [4-methoxy-l- (3-methylaminopropyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[5-methoxy-l-(3-methylaminopropyl)-IH-indol-3-yl]-maleinimid; 2- (1H-indol-3-yl) -3- [5-methoxy-1- (3-methylaminopropyl) -IH-indol-3-yl] -maleimide;

_₁₆₄-_ ₁₆₄ -

2-(lH-Indol-3-yl)-3-[6~methoxy-l-(3-methylaminopropyl)-iH-indol-3-yl ] -maleinim.' d;2- (1H-Indol-3-yl) -3- [6-methoxy-1- (3-methylaminopropyl) -iH-indol-3-yl] -maleimide. d;

2-(lH-Indol»3-yl)-3-[7-methoxy-l-(3~methylaminopropyl)-iH-indol-3-yl]-maleinimid;2- (lH-Indol »3-yl) -3- [7-methoxy-l- (3 ~ methylaminopropyl) -IH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[l-(3-methylaminopropyl)-4,5-methylendioxy-•lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [l- (3-methylaminopropyl) -4,5-methylenedioxy-• lH-indol-3-yl] -maleimide;

2-(lH-Indol--3-yl)-3-[1-(3-ii'Stuy?>aminopropyl)-5,6-methylendioxylH-indol-3-yl]-maleinimid;2- (lH-indole - 3-yl) -3- [1- (3-ii'Stuy> aminopropyl?) -5,6-methylendioxylH-indole-3-yl] maleimide;

2-(lH-Indol-3-yl)-3-[1-(3-mothylaminopropyl)-6,7-methylendioxylH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [1- (3-mothylaminopropyl) -6,7-methylendioxylH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[4-methyl-l-(3-methylaminopropyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [4-methyl-l- (3-methylaminopropyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[5-methyl-l-(3-methylaminopropyl)-lII-indol-3 -yl]-maleinimid;2- (1H-indol-3-yl) -3- [5-methyl-1- (3-methylaminopropyl) -II-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[6-methyl-l-(3-methylaminopropyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [6-methyl-l- (3-methylaminopropyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[7-methyl-l-(3-methylaroinopropyl)-lH-indol-3-y1]-maleinimid;2- (lH-indol-3-yl) -3- [7-methyl-l- (3-methylaroinopropyl) -lH-indol-3-y1] maleimide;

2-(lH-Indol-3-yl)-3-[l-(3-methylaminopropyl)-4-nitro-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [l- (3-methylaminopropyl) -4-nitro-lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[l-(3-methylaminopropyl)-5-nitro-lH-indol-3-y1]-maleinimid;2- (lH-indol-3-yl) -3- [l- (3-methylaminopropyl) -5-nitro-lH-indol-3-y1] maleimide;

2-(lH-Indol-3-yl)-3-[l-(3-methylaminopropyl)-6-nitro-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [l- (3-methylaminopropyl) -6-nitro-lH-indol-3-yl] -maleimide;

2-(lH-Iridol-3-yl)-3-[l-(3-methylan.inopropyl)-7-nitro-lH-indol-3-y1]-maleinimid;2- (lH-Iridol-3-yl) -3- [l- (3-methylan.inopropyl) -7-nitro-lH-indol-3-y1] maleimide;

2-(lH-Indol-3-yl)-3-[l-(3-methylaminopvüpyl)-4-inethyithio-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [l- (3-methylaminopvüpyl) -4-inethyithio-lH-indol-3-yl] -maleimide;

2-(lH-IndoI-3-yl)-3-[1-(3-methylaminopropyl)-5-methylthio-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [1- (3-methylaminopropyl) -5-methylthio-lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[l-(3-methylaminopropyl)-6-methylthio-lH-.indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [l- (3-methylaminopropyl) -6-methylthio-lH-.indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[1-(3-methylaminopropyl)-7-methylthio-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [1- (3-methylaminopropyl) -7-methylthio-lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[4,5-dimethoxy-l-(3-methylaminopropyl)-IH-indol-3-yl]-maleinimid; 2- (1H-indol-3-yl) -3- [4,5-dimethoxy-1- (3-methylaminopropyl) -IH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[5,6-dimethoxy-l-(3-methylaminopropyl)-IH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [5,6-dimethoxy-l- (3-methylaminopropyl) -IH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[6,7-dimethoxy-l-(3-methylaminopropyl)-IH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [6,7-dimethoxy-l- (3-methylaminopropyl) -IH-indol-3-yl] -maleimide;

2-[4-Acetylamino-l-(3"(4-morpholino)propyl)-lH-indol-3-yl]~3-(lH-indol-3-yl)-maleinimid;2- [4-acetylamino-l- (3 '(4-morpholino) propyl) -lH-indol-3-yl] ~ 3- (lH-indol-3-yl) maleimide;

2-[5-Acetylamino-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleininid;2- [5-Acetylamino-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) -maleininid;

2-[6-Acetylamino-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [6-acetylamino-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[7-Acetylamino-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [7-acetylamino-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[4-Amino-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [4-amino-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[5-Amino-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [5-Amino-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

-166--166-

2-[6-Amino-l-(3-(4-morpholino)propyl)-Ιή-ίηάοΙ-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [6-amino-l- (3- (4-morpholino) propyl) -Ιή-ίηάοΙ-3-yl] -3- (IH-indol-3-yl) maleimide;

2-L7-Amino-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2-L7-Amino-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-(4-Benzyloxy-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(IH- - indol-3-yl)-maleinimid;2- (4-Benzyloxy-1- (3- (4-morpholino) propyl) -1H-indol-3-yl] -3- (IH- - indol-3-yl) -maleimide;

2-[5-Benzyloxy-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleininid;2- [5-benzyloxy-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) -maleininid;

2-[6-Benzyloxy-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [6-benzyloxy-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[7-Benzyloxy-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [7-benzyloxy-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[4-Brom-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [4-bromo-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[5-Brom-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-3~(lH-indol-3-yl)-maleinimid;2- [5-bromo-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -3 ~ (lH-indol-3-yl) maleimide;

2-[6-Brom-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [6-bromo-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[7-BrOm-I-(3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleiniEid;2- [7-bromo-I- (3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) -maleiniEid;

2-[4-Chlor-l-(3-(4-morpholino)propyl)-lH-indol-3--yl]-3-(lH-indol-3-yl)-maleinimid;2- [4-chloro-l- (3- (4-morpholino) propyl) -lH-indol-3 - yl] -3- (lH-indol-3-yl) maleimide;

2-[5-Chlor-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [5-chloro-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[6-Chlor-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid; 2- [6-chloro-1- (3- (4-morpholino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

Z9?9?OZ9? 9? O

2-[7-Chlor-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [7-chloro-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[4-Fluor-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [4-fluoro-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

Si 2-[5-Fluor-l-(3-(4-morpholino)pi.Opyl)-lH-indol-3-yl]-3-(lH-.indol-3-yl)-maleinimid;Si 2- [5-fluoro-1- (3- (4-morpholino) -pi.-octyl) -1H-indol-3-yl] -3- (1H-.indol-3-yl) -maleimide;

2-[6-Fluoi-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [6-Fluoi-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[7-Fluor-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [7-fluoro-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[4-Hydroxy-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [4-hydroxy-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[5-Hydroxy-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [5-hydroxy-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[6-Hydroxy-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [6-hydroxy-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[7-Hydroxy-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [7-hydroxy-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[4-Trifluormethyl-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]· 3-(lH-indol-3-yl)-maleinimid;2- [4-trifluoromethyl-1- (3- (4-morpholino) propyl) -1H-indol-3-yl] .3- (1H-indol-3-yl) -maleimide;

2-[5-Trifluormethyl-1-(3-(4-morpholino)propyl)-lH-indol-3-yl] 3-(lH-indol-3-yl) -maleinimid;2- [5-trifluoromethyl-1- (3- (4-morpholino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[6-Trifluormethyl-1-(3-(4-morpholino)propyl)-lH-indol-3-yl] 3-(lH-indol-3-yl)-maleinimid;2- [6-trifluoromethyl-1- (3- (4-morpholino) propyl) -1H-indol-3-yl] 3- (1H-indol-3-yl) -maleimide;

2-[7-Trifluormethyl-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [7-Trifluoromethyl-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

_₁₆₈__ ₁₆₈ _

2-(lH-Indol-3-yl)-3-[4-methoxy-l-(3-(4-morpholino)propyl)-IH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [4-methoxy-l- (3- (4-morpholino) propyl) -IH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[6-methoxy-l-(3-(4-morpholino)propyl)-IH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [6-methoxy-l- (3- (4-morpholino) propyl) -IH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[7-methoxy-l-(3-(4-morpholino)propyl)-lH-.indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [7-methoxy-l- (3- (4-morpholino) propyl) -lH-.indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[4,5-methylendioxy-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [4,5-methylenedioxy-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[5,6-methylendioxy-l-(3-(4-morpholino) propyl)-lH-indol-3-yl]-maleinijnid;2- (1H-indol-3-yl) -3- [5,6-methylenedioxy-1- (3- (4-morpholino) -propyl) -1H-indol-3-yl] -maleinijnide;

2-(lH-Indol-3-yl)-3-[6_/7-methylendioxy-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- _{[6/7-methylenedioxy-l-} (3- (4-morpholino) propyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[4-methyl-l-(3-(4-morpholino)propyl)-Ihindol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [4-methyl-l- (3- (4-morpholino) propyl) -Ihindol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[5-methyl-l-(3-(4-morpholino)propyl)-IH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [5-methyl-l- (3- (4-morpholino) propyl) -IH-indol-3-yl] -maleimide;

2--(lH-Indol-3-yl)-3-[6-methyl-l-(3-(4-morpholino)propyl)-lH-.indol-3-yl ]-maleinimid;2 - (1H-indol-3-yl) -3- [6-methyl-1- (3- (4-morpholino) -propyl) -1H-.indol-3-yl] -maleimide;

2- (lH-Indol-3-yl) -3- [7-methyl-l-'_v 3- (4-morpholino) propyl) -IH-indol-3-yl]-maleinimid;2- (1H-indol-3-yl) -3- [7-methyl-1- _v 3- (4-morpholino) propyl) -1H-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[1-(3-(4-morpholino)propyl)-4-nitro-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [1- (3- (4-morpholino) propyl) -4-nitro-lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[l-(3-(4-morpholino)propyl)-5-nitro--lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [l- (3- (4-morpholino) propyl) -5-nitro - lH-indol-3-yl] -maleimide;

2-(lH-Indol-3~yl)-3-[l-(3-(4-moj.-pholino)propyl)-6-nitro-lH-indol-3-yl]-maleinimid;2- (lH-Indol-3 ~ yl) -3- [l- (3- (4-moj.-pholino) propyl) -6-nitro-lH-indol-3-yl] -maleimide;

-169--169-

2-(lH-Indol-3-yl)-3-[1-(3-(4-morpholino)propyl)-7-nitro-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [1- (3- (4-morpholino) propyl) -7-nitro-lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[4-methylthio-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [4-methylthio-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[5-methylthio-l-(3-(4-morpholino)propyl)-•lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [5-methylthio-l- (3- (4-morpholino) propyl) - • lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[6-methylthio-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [6-methylthio-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[7-methylthio-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [7-methylthio-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[4,5-dimethoxy-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [4,5-dimethoxy-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[5,6-dimethoxy-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [5,6-dimethoxy-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[6,7-dimethoxy-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [6,7-dimethoxy-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -maleimide;

2-[4-Acetylamino-l-(3-(2-nitroguanidino)propyl)-JH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [4-acetylamino-l- (3- (2-nitroguanidino) propyl) -JH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[5-Acetylamino-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [5-Acetylamino-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[6-Acet.ylamino-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [6-Acet.ylamino-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[7-Acetylamino-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [7-acetylamino-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[4-Amino-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimidι 2- [4-Amino-1- (3- (2-nitroguanidino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide ι

2-[5-Amino-l-(3-(2-nitroguanidino)propyl)-IH-indol-3-yl] -3-(1H-indol-3-yl)-maleinimid;2- [5-amino-1- (3- (2-nitroguanidino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[6-Amino-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [6-amino-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[7-Amino-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [7-amino-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[4-Benzyloxy-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [4-benzyloxy-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[5-Benzyloxy-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [5-benzyloxy-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[6-Ben2yloxy-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [6-Ben2yloxy-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[7-Benzyloxy-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [7-benzyloxy-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[4-Brom-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [4-bromo-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[5-Brom-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [5-bromo-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[6-Brom-i.-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [6-bromo-i .- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[7-Brom-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [7-bromo-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[4-Chlor-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [4-chloro-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[5-Chlor-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-3~(lH-indol-3-yl)-maleinimid;2- [5-chloro-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -3 ~ (lH-indol-3-yl) maleimide;

-171--171-

2-[6-Chlor-l-(3-(2-nitroguanid.no)propyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-raaleinimid;2- [6-chloro-l- (3- (2-nitroguanid.no) propyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) -raaleinimid;

2-[7-Chlor-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [7-chloro-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2- [ 4-Fluor-l- (3 - (2 -nitroguanidine) propyl) -lH-.indol -3 -y 1 ] -3 - (IH-• indol-3-yl)-maleinimid;2- [4-fluoro-1- (3 - (2-nitroguanidine) propyl) -1H-.indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[5-Fluor-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [5-fluoro-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[6-Fluor-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [6-fluoro-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[7-Fluor-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid; 2- [7-Fluoro-1- (3- (2-nitroguanidino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[4-Hydroxy-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [4-hydroxy-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[S-Hydroxy-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid; 2- [S -hydroxy-1- (3- (2-nitroguanidino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[6-Hydroxy-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid; 2- [6-Hydroxy-1- (3- (2-nitroguanidino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[7-Hydroxy-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [7-hydroxy-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2- [4-Trif ).uormethyl-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [4-Trif) .uormethyl-1- (3- (2-nitroguanidino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[5-Trifluormethyl-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [5-trifluoromethyl-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[6-Trifluormethyl-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [6-trifluoromethyl-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

-172--172-

2-[7-Trifluormethyl-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [7-Trifluoromethyl-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-(lH-Indol-3-yl)-3-[4"methoxy-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-ylJ-maleinimid;2- (lH-indol-3-yl) -3- [4 'methoxy-l- (3- (2-nitroguanidino) propyl) -lH-indole-3-YLJ-maleimide;

2-(lH-Indol~3-yl)-3-[5-methoxy-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol ~ 3-yl) -3- [5-methoxy-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[6-methoxy-l-( 3-(2-nitroguanidino) pt-opyi)-lH-indol-3-yl]-maleinimid;2- (1H-indol-3-yl) -3- [6-methoxy-1- (3- (2-nitroguanidino) pt-opyl) -1H-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[7-methoxy-l-(3-(2-nitroguanidinö)propyl)-lH-indol-3-yl]-maleininid;2- (lH-indol-3-yl) -3- [7-methoxy-l- (3- (2-nitroguanidinö) propyl) -lH-indol-3-yl] -maleininid;

2-(lH-Indol-3-yl)-3-[4,5-methylendioxy-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [4,5-methylenedioxy-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3--[5,6-methylündioxy-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3 - [5,6-methylündioxy-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[6,7-methylendioxy-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [6,7-methylenedioxy-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[4-methyl-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [4-methyl-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[5-methyl-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [5-methyl-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[6-methyl-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-n)dleinimid;2- (lH-indol-3-yl) -3- [6-methyl-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -n) dleinimid;

2-(lH-Indol-3-yl)-3-[7-methyl-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-y1]-maleinimid;2- (lH-indol-3-yl) -3- [7-methyl-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-y1] maleimide;

2-(lH-Indol-3-yl)-3-[4-nitro-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [4-nitro-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -maleimide;

-173--173-

2~(lH-Indol-3-yl)-3-[5-nitro-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-mcileinimid;2 ~ (lH-Indol-3-yl) -3- [5-nitro-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -mcileinimid;

2-(lH-Indol-3-yl)-3-[6-nitro-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [6-nitro-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[7-nitro-l-(3-(2-nitroguanidino)propyl)-lH-• indol-3-yl]-maleinimid;2- (1H-indol-3-yl) -3- [7-nitro-1- (3- (2-nitroguanidino) propyl) -1H-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[4-methylthio-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [4-methylthio-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[5-methylthio-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [5-methylthio-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[6-methylthio-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [6-methylthio-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[7-methylthio-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [7-methylthio-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[4,5-dimethoxy-l-(3-(2-nitroguanidino)propyl)-IH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [4,5-dimethoxy-l- (3- (2-nitroguanidino) propyl) -IH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[5,6-dimethoxy-l-(3-(2-nitroguanidino)propyl)-lH-indol~3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [5,6-dimethoxy-l- (3- (2-nitroguanidino) propyl) -lH-indol ~ 3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-t6,7-dimethoxy-l-(3-(2-0 nitroguanidino) propyl) - "> H-indol-3-y 1 ] -maleinimid;2- (1H-indol-3-yl) -3-t6,7-dimethoxy-1- (3- (2-0-nitroguanidino) propyl) - "> H-indol-3-yl] -maleimide;

2-[4-Acetylamino-l-(3-(l-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [4-acetylamino-l- (3- (l-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[5-Acetylamino-l-(3-(l-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [5-Acetylamino-l- (3- (l-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[6-Acetylaroino-l-(3-(l-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [6-Acetylaroino-l- (3- (l-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

-174--174-

2-[7-Acetylamino-l- (3- (l-piperidino) piopy 1) -lH-indol-3-yl] -3-· (lH-indol-3-yl)-maleinimid;2- [7-acetylamino-1- (3- (1-piperidino) -piopy1) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[4-Amino-l-(3-(1-piperidino)propyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [4-amino-l- (3- (1-piperidino) propyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[5-Amino-l-(3-(l-piperidino)propyl)-lH-indol-3~yl]-3-(lH-. indol-3-yl)-maleinimid;2- [5-amino-1- (3- (1-piperidino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[6-Amino-l-(3-(1-piperidino)propyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [6-amino-l- (3- (1-piperidino) propyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[7-Amino-l-(3-(1-piperidino)propyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [7-amino-l- (3- (1-piperidino) propyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[4-Benzyloxy-l-(3-(1-piperidino)propyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [4-benzyloxy-l- (3- (1-piperidino) propyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[5-Benzyloxy-l-(3-(1-piperidino)propyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [5-benzyloxy-l- (3- (1-piperidino) propyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[6-Benzyloxy-l-(3-(1-piperidino)propyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [6-benzyloxy-l- (3- (1-piperidino) propyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[7-Benzyloxy-l-(3-(1-piperidino)propyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [7-benzyloxy-l- (3- (1-piperidino) propyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[4-Brom-l-(3-(1-piperidino)propyl)-lH-indol-3~yl]-3-(IH-indol-3-yl)-maleinimid;2- [4-bromo-l- (3- (1-piperidino) propyl) -lH-indol-3 ~ yl] -3- (IH-indol-3-yl) maleimide;

2-[5-Brom-l-(3-(1-piperidino)propyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [5-bromo-l- (3- (1-piperidino) propyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[6-Brom-l-(3-(1-piperidino)propyl)-lH-indol-3-yl]-3-(IK-indol-3-yl) -maleir.imid;2- [6-bromo-1- (3- (1-piperidino) propyl) -1H-indol-3-yl] -3- (1K-indol-3-yl) -maleimide;

2-[7-Brom-l-(3-(1-piperidino)propyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-waleinimid;2- [7-bromo-l- (3- (1-piperidino) propyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) -waleinimid;

2-[4-Chlor-l-(3-(l"piperidinc)propyl)-lH-indol-3-yl]-3-(lH-indo3.-3~yl) -maleinimid;2- [4-chloro-1- (3- (1-piperidine) propyl) -1H-indol-3-yl] -3- (1H-indo-3,3-yl) -maleimide;

2-[5-Chlor-l-(3-(l-piperidino)propyl)-lH~indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [5-chloro-l- (3- (l-piperidino) propyl) -lH ~ indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[6-Chlor-l-(3-(l-piperidino)propyl)-lH-indol-3-yi]-3-(IH-indol-3-yl)-maleinimid;2- [6-chloro-l- (3- (l-piperidino) propyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[7-Chlor-l-(3-(l-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [7-chloro-l- (3- (l-piperidino) propyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[4-Fluor-l-(3-(l-piperidino)propyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [4-fluoro-l- (3- (l-piperidino) propyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[5-Fluor-l-(3-(l-piperidino)propyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [5-fluoro-l- (3- (l-piperidino) propyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[6-Fluor-l-(3-(l-piperidino)propyl)-IH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [6-fluoro-l- (3- (l-piperidino) propyl) -IH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[7-Fluor-l-(3-(l-piperidino)propyl)-lH-indol-3-yl]-3-(lH-indol-3-yl) -raaleiriimid;2- [7-Fluoro-1- (3- (1-piperidino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -raaleirimide;

2-[4-Hydroxy-1-(3-(l-piperidino)propyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [4-hydroxy-1- (3- (l-piperidino) propyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[5-Hydroxy-l-(3-(l-piperidino)propyl)-IH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [5-hydroxy-l- (3- (l-piperidino) propyl) -IH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[6-Hydroxy-l-(3-(l-piperidino)prcpyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [6-hydroxy-l- (3- (l-piperidino) prcpyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[7-Hydroxy-l-(3-(l-piperidino)propyl)-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [7-hydroxy-l- (3- (l-piperidino) propyl) -lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[4-Trifluormethyl-l-(3-(l-piperidino)propyl)-IH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [4-trifluoromethyl-l- (3- (l-piperidino) propyl) -IH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[5-Trifluormethyl-l-(3-(l-piperidinojpropyl) -lll-indol- 3-yl]-3-(lH-indol-3-yl)-malsinimid;2- [5-trifluoromethyl-1- (3- (1-piperidino-propyl) -11-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[6-Trifluormethyl-1-(3-(!-piperidino)propyl)-lH-indol-3-yl] · 3-(lH-indol-3-yl)-maleinimid;2- [6-trifluoromethyl-1- (3 - (- (piperidino) propyl) -1H-indol-3-yl] .3- (1H-indol-3-yl) -maleimide;

2-[7-Trifluormethyl-l-(3-(1-piperidino)propyl)-lH-indol-3-yl] .3-(lH-indol-3-yl)-maleinimid;2- [7-trifluoromethyl-1- (3- (1-piperidino) propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-(lH-Indol-3-yl)-3-[4-methoxy-l-(3-(1-piperidino)propyl)-IH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [4-methoxy-l- (3- (1-piperidino) propyl) -IH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[5-methoxy-l-(3-(!-piperidino)propyl)-IH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- maleimide [5-methoxy-l- -IH-indol-3-yl (3 - - (piperidino) propyl!)];

2-(lH-Indol-3-yl)-3-[6-methoxy-l-(3-(1-piperidino)propyl)-IH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [6-methoxy-l- (3- (1-piperidino) propyl) -IH-indol-3-yl] -maleimide;

2-(lH-Indoi-l-f±)-3-[7-methoxy-l-(3-(1-piperidino)propyl)-IH-indol-3-' /.. -maleinimid;2- (1H-Indo-1- ol) -3- [7-methoxy-1- (3- (1-piperidino) propyl) -IH-indole-3- '' -. -Maleimide;

2-(lH-Indol-3-yl)-3-[4,5-methylendioxy-l-(3-(1-piperidino)propyl)-lH-indol-3-y1]-maleinimid;2- (lH-indol-3-yl) -3- [4,5-methylenedioxy-l- (3- (1-piperidino) propyl) -lH-indol-3-y1] maleimide;

2-(lH-Indol-3-yl)-3-[5,6-methylendioxy-l-(3-(1-piperidino)propyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [5,6-methylenedioxy-l- (3- (1-piperidino) propyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[6,7-methylendioxy-l-(3-(lpiperidino)propyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [6,7-methylenedioxy-l- (3- (lpiperidino) propyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[4-methyl-l-(3-(1-piperidino)propyl)-IH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [4-methyl-l- (3- (1-piperidino) propyl) -IH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[5-methyl-l-(3-(1-piperidino)propyl)-IH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [5-methyl-l- (3- (1-piperidino) propyl) -IH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[6-methyl-l-(3-(1-piperidino)propyl)-IH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [6-methyl-l- (3- (1-piperidino) propyl) -IH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[7-methyl-l-(3-(l-piperidino)propyl)-iH-indo.l-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [7-methyl-l- (3- (l-piperidino) propyl) -IH-indo.l-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[4-nitro-l-(3-(!--piperidino) propyl)-IH-indol-3-yl]-maleinimid;2- (1H-indol-3-yl) -3- [4-nitro-1- (3 - (- (piperidino) propyl) -1H-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[5-nitro-l-(3-(1-piperidino)propyl)-IH-indol-3-yl]-maleininid;2- (lH-indol-3-yl) -3- [5-nitro-l- (3- (1-piperidino) propyl) -IH-indol-3-yl] -maleininid;

2-(lH-Indol-3-yl)-3-[6-nitro-1-(3-(1-piperidino)propyl)-IH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [6-nitro-1- (3- (1-piperidino) propyl) -IH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[7-nitro-l-(3-(1-piperidino)propyl)-IH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [7-nitro-l- (3- (1-piperidino) propyl) -IH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[4-methylthio-l-(3-(1-piperidino)propyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [4-methylthio-l- (3- (1-piperidino) propyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[5-methylthio-l-(3-(1-piperidino)propyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [5-methylthio-l- (3- (1-piperidino) propyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[6-methylthio-l-(3-(1-piperidino)propyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [6-methylthio-l- (3- (1-piperidino) propyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[7-methylthio-l-(3-(1-piperidino)propyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [7-methylthio-l- (3- (1-piperidino) propyl) -lH-indol-3-yl] -maleimide;

2- (lH-Indol-3-yl) -3-[4,5-dimethoxy-l- (3- (.!-piperidino) propyl) lH-indol-3-yl]-maleinimid;2- (1H-Indol-3-yl) -3- [4,5-dimethoxy-1- (3- (.! - piperidino) -propyl) -1H-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[5,6-dimethoxy-l-(3-(1-piperidino)propyl) lH-indol-3-yl]-maleinimid;2- (1H-indol-3-yl) -3- [5,6-dimethoxy-1- (3- (1-piperidino) -propyl) -1H-indol-3-yl] -maleimide;

2-(lH-Indoi-3-yl)-3-[6,7-dimethoxy-l-(3-(1-piperidino)propyl) lH-indol-3-yl]-maleinimid; Bis-2,3-(4-acetylamino-lH-indol-3-yl)-maleinimid; Bis-2,3-(ö-acetylamino-lH-indol-S-yl)-maleinimid;2- (1H-Indo-3-yl) -3- [6,7-dimethoxy-1- (3- (1-piperidino) -propyl) -1H-indol-3-yl] -maleimide; Bis-2,3- (4-acetylamino-lH-indol-3-yl) maleimide; Bis-2,3- (o-acetylamino-lH-indol-S-yl) maleimide;

-173-Bis-2,3-(ö-acetylamino-lH-indol-j-yl)-maleinimid;-173-bis-2,3- (o-acetylamino-lH-indol-j-yl) maleimide;

Bis-2,3-(7-acetylamino-lH-indol-3-yl)-maleinimid; Bis-2,3-(4-amino-lH-indol-3-yl)-maleinimid; Bis-2,3-(5-amino-lH-indol-3-yl)-maleinimid; Bis-2,3-(6-amino-lH-indol"3-yl)-maleinimid; Bis-2,3-(7-amino-lH-indol-3-yl)-maleinimid; Bis-2,3-(4-benzyloxy-lH-indol-3-yl)-maleinimid; Bis-2,3-(6-benzyloxy-lH-indol-3-yl)-maleinimid; Bis-2,3-(7-benzyloxy-lH-indol-3-yl)-maleinimid; Bis-2,3-(4-brom-lH-indol-3-yl)-maleinimid;Bis-2,3- (7-acetylamino-lH-indol-3-yl) maleimide; Bis-2,3- (4-amino-lH-indol-3-yl) maleimide; Bis-2,3- (5-amino-lH-indol-3-yl) maleimide; Bis-2,3- (6-amino-1H-indol-3-yl) -maleimide; bis-2,3- (7-amino-1H-indol-3-yl) -maleimide; bis-2,3- (4-benzyloxy-1H-indol-3-yl) -maleimide; bis-2,3- (6-benzyloxy-1H-indol-3-yl) -maleimide; bis-2,3- (7-benzyloxy-1H; -indol-3-yl) -maleimide; bis-2,3- (4-bromo-1H-indol-3-yl) -maleimide;

Bis-2,3-(6-brom-lH-indol-3-yl)-maleinimid;Bis-2,3- (6-bromo-lH-indol-3-yl) maleimide;

Bis-2,3-(7-brom-lH-indol-3-yl)-maleinimid;Bis-2,3- (7-bromo-lH-indol-3-yl) maleimide;

Bis-2,3-(4-chlor-lH-indol-3-yl)-maleinimid; Bis-2,3-(6-chlor-lH-indol-3-yl)-maleinimid; Bis-2,3-(7-chlor-lH-indol-3-yl)-maleinimid; Bis-2,3-(4-fluor-lH-indol-3-yl)-maleinimid; Bis-2,3-(S -fluor-lH-indol-3-yl)-maleinimid; Bis-2,3-(7-fluor-lH-indol-3-yl)-maleinimid;Bis-2,3- (4-chloro-lH-indol-3-yl) maleimide; Bis-2,3- (6-chloro-lH-indol-3-yl) maleimide; Bis-2,3- (7-chloro-lH-indol-3-yl) maleimide; Bis-2,3- (4-fluoro-lH-indol-3-yl) maleimide; Bis-2,3- (S -fluoro-1H-indol-3-yl) -maleimide; Bis-2,3- (7-fluoro-lH-indol-3-yl) maleimide;

Bis-2,3-(4-hydroxy-lH-indol-3-yl)-maleinimid; 2υ Bis-2,3-(5-hydroxy-lH-indol-3-yl)-maleinimid?Bis-2,3- (4-hydroxy-lH-indol-3-yl) maleimide; 2υ bis-2,3- (5-hydroxy-1H-indol-3-yl) -maleimide?

-179--179-

Bis-2,3-(7-hydroxy-lH-indol-3-yl)-maleinimid; Bis-2,3-(4-trifluormethyl-lH-indol-3-yl)-maleinimid; Bis-2,3-(5-trifluormethyl-lH-indol-3-yl)-maleinimid; Bis-2,3-(6-trifluormethyl-lH-indol-3-yl)-maleinimid; Bis-2,3-(7-trifluormethyl-lH-indol-3-yl)-maleinimid; Bis-2,3-(4-methoxy-lH-indol-3-yl)-maleinimid; Bis-2,3-(6-methoxy-lH-indol-3-yl)-maleinimid; Bis-2,3-(7-methoxy-lH-indul-3-yl)-maleinimid; 3is-2,3-(4,S-methylendioxy-lH-indol-S-yl)-maleinimid; Bis-2,3-(6,7-methylendioxy-lH-indol-3-yl)-maleinimid; Bis-2,3-(4-methyl-lH-indol-3-yl)-maleinimid; Bis-2,3-(6-methyl-lH-indol-3-yl)-maleinimid; Bis-2,3-(7-methyl-lH-indol-3-yl)-maleinimid; Bis-2,3-(4-nitro-lH-indol-3-yl)-maleinimid; Bis-2,3-(5-nitro-lH-indol-3-yl)-maleinimid; Bis-2,3-(6-nitro-lH-indol-3-yl)-ualeinimid; Bis-2,3-(7-nitro-lH-indol-3-yl)-maleinimid; Bis-2,3-(4-methylthio-lH-indol-3-yl)-maleinimid; 0 Bis-2,3-(5-methylthio-lH-indol-3-yl)-maleinimid;Bis-2,3- (7-hydroxy-lH-indol-3-yl) maleimide; Bis-2,3- (4-trifluoromethyl-lH-indol-3-yl) maleimide; Bis-2,3- (5-trifluoromethyl-lH-indol-3-yl) maleimide; Bis-2,3- (6-trifluoromethyl-lH-indol-3-yl) maleimide; Bis-2,3- (7-trifluoromethyl-lH-indol-3-yl) maleimide; Bis-2,3- (4-methoxy-lH-indol-3-yl) maleimide; Bis-2,3- (6-methoxy-lH-indol-3-yl) maleimide; Bis-2,3- (7-methoxy-lH-indul-3-yl) maleimide; 3IS-2,3- (4, S-methylenedioxy-lH-indol-S-yl) maleimide; Bis-2,3- (6,7-methylenedioxy-lH-indol-3-yl) maleimide; Bis-2,3- (4-methyl-lH-indol-3-yl) maleimide; Bis-2,3- (6-methyl-lH-indol-3-yl) maleimide; Bis-2,3- (7-methyl-lH-indol-3-yl) maleimide; Bis-2,3- (4-nitro-lH-indol-3-yl) maleimide; Bis-2,3- (5-nitro-lH-indol-3-yl) maleimide; Bis-2,3- (6-nitro-lH-indol-3-yl) -ualeinimid; Bis-2,3- (7-nitro-lH-indol-3-yl) maleimide; Bis-2,3- (4-methylthio-lH-indol-3-yl) maleimide; 0 bis-2,3- (5-methylthio-1H-indol-3-yl) -maleimide;

-₁₈ο-- ₁₈ o-

Bis-2,3- (6-n>ethylthio-lH-indol-3-yl j -ialeinimid; Bis-2,3-(7-methylthio-lH-indol-3-yl)-maleinimid; Bis-2,3-(4,5-dimethoxy-lH-indol-3-yl)-maleinimid; Bis-2,3-(5,6-dimethoxy-lH-indol-3-yl)-maleinimid; Bis-2,3-(6,7-dimethoxy-lH-indol-3-yl)-maleinimid;Bis-2,3- (6-n-ethylthio-1H-indol-3-yl) -ialeinimide; bis-2,3- (7-methylthio-1H-indol-3-yl) -maleimide; bis-2, 3- (4,5-dimethoxy-1H-indol-3-yl) -maleimide; bis-2,3- (5,6-dimethoxy-1H-indol-3-yl) -maleimide; bis-2,3- (6,7-dimethoxy-lH-indol-3-yl) maleimide;

2-[5-Acetylamino-l-(3-(amidinothio)propyl)-lH-indol-3-yl]-3-(5-acetylamino-lH-indol-3-yl)-maleinimid;2- [5-Acetylamino-l- (3- (amidinothio) propyl) -lH-indol-3-yl] -3- (5-acetylamino-lH-indol-3-yl) maleimide;

2-[l-(3-(Amidinothio)propyl)-5-amino-lH-indol-3-yl]-3-(5-aminolH-indol-3-yl)-maleinimid;2- [l- (3- (amidinothio) propyl) -5-aminolH-indol-3-yl] -3- (5-aminolH-indol-3-yl) maleimide;

2-[1-(3-(Amidinothio)propyl)-S-benzyloxy-lH-indol-S-yl]-3-(5-benzyloxy-lH-indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -S-benzyloxy-lH-indol-S-yl] -3- (5-benzyloxy-lH-indol-3-yl) maleimide;

2-[1-(3-(Amidinothio)propyl)-5-brom-lH-indol-3-yl]-3-(5-bromlH-indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -5-bromlH-indol-3-yl] -3- (5-bromlH-indol-3-yl) maleimide;

2-[1-(3-(Amidinothio)propyl)-S-chlor-lH-indol-S-yl]-3-(5-chlor-IH-indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -S-chloro-lH-indol-S-yl] -3- (5-chloro-IH-indol-3-yl) maleimide;

2-[1-(3-(Amidinothio)propyl)-5-fluor-lH-indol-3-yl]-3-(5-fluorlH-indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -5-fluorlH-indol-3-yl] -3- (5-fluorlH-indol-3-yl) maleimide;

2-[1-(3-(Amidinothio)propyl)-5-hydroxy-lH-indol-3-yl]-3-(5-byJroxy-lH-indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -5-hydroxy-lH-indol-3-yl] -3- (5-byJroxy-lH-indol-3-yl) maleimide;

2-[l-(3-(Amidinothio)propyl)-S-trifluormethyl-lH-indol-s-yl]-3-(5-trifluormethyl-lH-indol-3-yl)-maleinimid;2- [l- (3- (amidinothio) propyl) -S-trifluoromethyl-lH-indol-s-yl] -3- (5-trifluoromethyl-lH-indol-3-yl) maleimide;

2-[l-(3-(Amidinothio)propyl)-5-methoxy-lH-indol-3-yl]-3-(5-methoxy-lH-indol-3-yl)-maleinimid;2- [l- (3- (amidinothio) propyl) -5-methoxy-lH-indol-3-yl] -3- (5-methoxy-lH-indol-3-yl) maleimide;

2-[1~(3-(Amidinothio)propyl)-4,S-methylendioxy-lH-indol-S-yl]-3-(4,5-methylendioxy-lH-indol-3-yl)-maleinimid; 2- [1- (3- (amidinothio) propyl) -4, S -methylenedioxy-1H-indol-S-yl] -3- (4,5-methylenedioxy-1H-indol-3-yl) -maleimide;

-181--181-

2-[l-( 3-(Amidinothio) propyl)-5,6-n>.etnylendioxy-lH-indol-3-yl]-3-(5,6-methylendioxy-lH-indol-3-yl)-maleinimid;2- [1- (3- (Amidinothio) propyl) -5,6-n> .ethnylenedioxy-1H-indol-3-yl] -3- (5,6-methylenedioxy-1H-indol-3-yl) - maleimide;

2-[1-(3-(Amidinothio)propyl)-5-methyl-lH-indol-3-yl]-3-(5-methyl-lH-indol-o-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -5-methyl-lH-indol-3-yl] -3- (5-methyl-lH-indol-o-yl) maleimide;

' 2-[1-(3-(Amidinothio)propyl)-5-nitro-lH-indol-3-yl]-3-(5-nitro-. lH-ind.ol-3-yl) -maleinimid;'2- [1- (3- (amidinothio) propyl) -5-nitro-1H-indol-3-yl] -3- (5-nitro-1H-indol-3-yl) -maleimide;

2-[1-(3-(Amidinothio)propyl)-5-methylthio-lH-indol-3-yl]-3-(5-methylthio-lH-indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -5-methylthio-lH-indol-3-yl] -3- (5-methylthio-lH-indol-3-yl) maleimide;

2-[1-(3-(Amidinothio)propyl)-4,5-dimethoxy-lH-indol-3-yl]-3-(4,5-dimethoxy-lH~indol-3-yl)-maleinimid;2- [1- (3- (amidinothio) propyl) -4,5-dimethoxy-lH-indol-3-yl] -3- (4,5-dimethoxy-lH ~ indol-3-yl) maleimide;

2-t1-(3-(Amidinothio)propyl)-5,6-dimethoxy-lH-indol-3-yl]-3-(5,6-dimethoxy-lH-indol-3-yl)-naleinimid;2-t1- (3- (amidinothio) propyl) -5,6-dimethoxy-lH-indol-3-yl] -3- (5,6-dimethoxy-lH-indol-3-yl) -naleinimid;

2-[5-Acetylamino-l-(2-aminoethyl)-lH-indol-3-yl]-3-(5-acetylamino-lH-indol-3-yl)-maleinimid;2- [5-Acetylamino-l- (2-aminoethyl) -lH-indol-3-yl] -3- (5-acetylamino-lH-indol-3-yl) maleimide;

2-[5-Amino-l-(2-aminoethyl)-lH-indol-3-yl]-3-(5-amino-lH-indol-3-yl)-maleinimid;2- [5-amino-l- (2-aminoethyl) -lH-indol-3-yl] -3- (5-amino-lH-indol-3-yl) maleimide;

2-[l-(2-Aminoethyl)-5-benzyloxy-lH-indol-3-yl]-3-(5-benzyloxylH-indol-3-yl)-maleinimid;2- [l- (2-aminoethyl) -5-benzyloxylH-indol-3-yl] -3- (5-benzyloxylH-indol-3-yl) maleimide;

2-[l-(2-Aminoethyl)-5-brom-lH-indol-3-yl]-3-(5-brom-lH-indol-3-0 yl)-maleinimid;2- [1- (2-aminoethyl) -5-bromo-1H-indol-3-yl] -3- (5-bromo-1H-indol-3-o-yl) -maleimide;

2-[l-(2-Aminoethyl)-5-chlor-lH-indol-3-yl]-3-(5-chlor-lH-indol-3-yl)-maleinimid;2- [l- (2-aminoethyl) -5-chloro-lH-indol-3-yl] -3- (5-chloro-lH-indol-3-yl) maleimide;

2-[l-(2-Aminoethyl)-5-fluor-lH-indol-3-yl]-3-(5-fluor-lH-indol-3-yl)-maleinimid;2- [l- (2-aminoethyl) -5-fluoro-lH-indol-3-yl] -3- (5-fluoro-lH-indol-3-yl) maleimide;

2-[l-(2-Aminoethyl)-5-hydroxy-lH-indol-3-yl]-3-(5-hydroxy-lH-indol-3-yl)-maleinimid;2- [l- (2-aminoethyl) -5-hydroxy-lH-indol-3-yl] -3- (5-hydroxy-lH-indol-3-yl) maleimide;

2 -182- 2 -182-

2- [1- (2-Aminoethyl) -5-trif luormetnyl-lH-ir.dol- 3-yi] -3- (5-trifluormethyl-lH-indol-3-yl)-maleinimid;2- [1- (2-aminoethyl) -5-trifluoromethenyl-1H-di-ol-3-yl] -3- (5-trifluoromethyl-1H-indol-3-yl) -maleimide;

2-[1-(2-Aminoethyl)-S-methoxy-lH-indol-S-yl]-3-(5-methoxy-lH-indol-3-yl)-maleinimid;2- [1- (2-aminoethyl) -S-methoxy-lH-indol-S-yl] -3- (5-methoxy-lH-indol-3-yl) maleimide;

2-[1-(2-Aminoethyl)-4,5-methylendioxy-lH-indol-3-yl]-3-(4,5-.methylendioxy-lH-indol-3-yl)-maleinimid;2- [1- (2-Aminoethyl) -4,5-methylenedioxy-lH-indol-3-yl] -3- (4,5-.methylendioxy-lH-indol-3-yl) maleimide;

2-[1-(2-Aminoethyl)-5,6-methylendioxy-lH-indol-3-yl]-3-(5, methylendioxy-lH-indol-3-yl)-maleinimid;2- [1- (2-aminoethyl) -5,6-methylenedioxy-1H-indol-3-yl] -3- (5-methylenedioxy-1H-indol-3-yl) -maleimide;

2-[l-(2-Aminoethyl)-S-methyl-lH-indol-S-yl]-3-(5-methyl-lH-indol-3-yl)-maleinimid;2- [l- (2-aminoethyl) -S-methyl-lH-indol-S-yl] -3- (5-methyl-lH-indol-3-yl) maleimide;

2-[1-(2-Aminoethyl)-5-nitro-lH-indol-3-yl]-3-(5-nitro-lH-indol-3-yl)-maleinimid;2- [1- (2-aminoethyl) -5-nitro-lH-indol-3-yl] -3- (5-nitro-lH-indol-3-yl) maleimide;

2-[1-(2-Aminoethyl)-5-methylthio-IH-indcl-3-yl]-3-(5-methylthio-lH-indol-3-yl)-maleinimid;2- [1- (2-aminoethyl) -5-methylthio-IH-indcl-3-yl] -3- (5-methylthio-lH-indol-3-yl) maleimide;

2-[1-(2-Aminoethyl)-4,5-dimethoxy-lH-indol-3-yl]-3-(4,5-dimethoxy-lH-indol-3-yl)-maleinimid;2- [1- (2-aminoethyl) -4,5-dimethoxy-lH-indol-3-yl] -3- (4,5-dimethoxy-lH-indol-3-yl) maleimide;

2-[1-(2-Aminoethyl)-5,6-dimethoxy-lH-indol-3-yl]-3-(5,6-dimethoxy-lH-indol-3-yl)-maleinimid;2- [1- (2-aminoethyl) -5,6-dimethoxy-lH-indol-3-yl] -3- (5,6-dimethoxy-lH-indol-3-yl) maleimide;

2-[5-Acetylamino-l-(3-aminopropyl)-lK-indol-3-yl]-3-(5-acetylamino-lH-indol-3~yl)-maleinimid;2- [5-Acetylamino-l- (3-aminopropyl) -LK-indol-3-yl] -3- (5-acetylamino-lH-indol-3 ~ yl) maleimide;

2-[5-Amino-l-(3-aminopropyl)-lH-indol-3-yl]-3-(5-amino-lH-indol-3-yl)-maleinimid;2- [5-Amino-l- (3-aminopropyl) -lH-indol-3-yl] -3- (5-amino-lH-indol-3-yl) maleimide;

2-[1-(3-Aminopropyl)-5-benzyloxy-lH-indol-3-yl]-3-(5-benzyloxy-IH-indol-3-yl)-maleinimid;2- [1- (3-aminopropyl) -5-benzyloxy-lH-indol-3-yl] -3- (5-benzyloxy-IH-indol-3-yl) maleimide;

2-[l-(3-Aminopropyl)-5-brom-lH-indol-3-yl]-3-(5-brom-lH-indol-3-yl)-maleinimid;2- [l- (3-aminopropyl) -5-bromo-lH-indol-3-yl] -3- (5-bromo-lH-indol-3-yl) maleimide;

-183--183-

2-[l-(3-Aminopropyl)-5-chlor-lH-indoi"3-yl]-2-(5-chlo£-lH-indol-3-yl)-maleinimid;2- [l- (3-aminopropyl) -5-chloro-lH-indol "3-yl] -2- (5-chlo £ -lH-indol-3-yl) maleimide;

2-[1-(3-Aminopropyl)-5-fluor-lH-indol-3-yl]-3-(5-fIuor-1H-indol-3-yl)-maleinimid;2- [1- (3-aminopropyl) -5-fluoro-lH-indol-3-yl] -3- (5-fluoro-1H-indol-3-yl) maleimide;

2-[l-(3-Aminopropyl)-5-hydroxy-lH-indol-3-yl]-3-(5-hydroxy-lH-indol-3-yl) -maleinixiiid;2- [1- (3-aminopropyl) -5-hydroxy-1H-indol-3-yl] -3- (5-hydroxy-1H-indol-3-yl) -maleinixide;

2-[1-(3-Aminopropyl)-S-trifluormethyl-lH-indol-S-yl]-3-(5-trifluormethyl-lH-indol-3-yl)-maleiniaid;2- [1- (3-aminopropyl) -S-trifluoromethyl-lH-indol-S-yl] -3- (5-trifluoromethyl-lH-indol-3-yl) -maleiniaid;

2-[l-(3-Aminopropyl)-5-methoxy-lH-indol-3-yl]-3-(5-methoxy-lH-indol-3-yl)-maleinimid;2- [l- (3-aminopropyl) -5-methoxy-lH-indol-3-yl] -3- (5-methoxy-lH-indol-3-yl) maleimide;

2-[1-(3-Aminopropyl)-4,5-methylendioxy-lH-indol-3-yl]-3-(4,5-methylendioxy-lH-indol-3-yl)-maleinimid;2- [1- (3-aminopropyl) -4,5-methylenedioxy-lH-indol-3-yl] -3- (4,5-methylenedioxy-lH-indol-3-yl) maleimide;

2-[1-(3-Aminopropyl)-5,6-methylendioxy-lH-indol-3-yl]-3-(5,6-methylendioxy-lH-indol-3-yl)-maleinimid;2- [1- (3-aminopropyl) -5,6-methylenedioxy-lH-indol-3-yl] -3- (5,6-methylenedioxy-lH-indol-3-yl) maleimide;

2-[1-(3-Aminopropyl)-S-methyl-lH-indol-S-yl]-3-(5-methyl-lH-indol-3-yl)-maleinimid;2- [1- (3-aminopropyl) -S-methyl-lH-indol-S-yl] -3- (5-methyl-lH-indol-3-yl) maleimide;

2-[I-(3-Aminopropyl)-S-nitro-lH-indol-3-yl]-3-(5-nitro-lH-indol-3-yl)-maleinimid;2- [I- (3-aminopropyl) -S-nitro-lH-indol-3-yl] -3- (5-nitro-lH-indol-3-yl) maleimide;

2-[1-(3-Aminopropyl)-S-methylthio-lH-indol-S-yl]-3-(5-methylthio-lH-indol-3-yl)-maleinimid;2- [1- (3-aminopropyl) -S-methylthio-lH-indol-S-yl] -3- (5-methylthio-lH-indol-3-yl) maleimide;

2-[l-(3-Aminopropyl)-4,5-dimethoxy-lH-indol-3-yl]-3-(4,5-dimethoxy-lH-indol-3-yl)-maleinimid;2- [l- (3-aminopropyl) -4,5-dimethoxy-lH-indol-3-yl] -3- (4,5-dimethoxy-lH-indol-3-yl) maleimide;

2-[l-(3-Aminoprcpyl)-5,6-dimethoxy-lH-indol-3-yl]-3-(5,6-dimethoxy-lH-indol-3-yl)-maleinimid;2- [l- (3-Aminoprcpyl) -5,6-dimethoxy-lH-indol-3-yl] -3- (5,6-dimethoxy-lH-indol-3-yl) maleimide;

(±)-2-[5-Acetylamino-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(S-acetylamino-lH-indol-?-vl)-maleinimid;(±) -2- [5-acetylamino-l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -3- (S-acetylamino-lH-indol - - vl?) Maleimide;

(±)-2-[5-Amino-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(5-amino-lH-indol-3-yl)-maleinimid;(±) -2- [5-amino-l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -3- (5-amino-lH-indol-3-yl) maleimide;

(±)-2-[5-Benzyloxy-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(5-benzyloxy-lH-indol-3-yl)-maleinimid;(±) -2- [5-benzyloxy-l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -3- (5-benzyloxy-lH-indol-3-yl) maleimide;

(±)-2-[5-Brom-l-(3-ethoxy-2-hydroxypropyl)-lIi-indoI-3-yl]-3-(5- -brom-lH-indol-3-yl)-maleinimid;(±) -2- [5-Bromo-1- (3-ethoxy-2-hydroxypropyl) -li-indol-3-yl] -3- (5-bromo-1H-indol-3-yl) -maleimide ;

(±)-2-[5-Chlor-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(5-chlor-lH-indol-3-yl)-mal'3inimid;(±) -2- [5-chloro-l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -3- (5-chloro-lH-indol-3-yl) times' 3inimid;

(±)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5-fluor-lh-indo¹"3-yl]-3-(5-fluor-lH-indol-3-yl)-maleinimid;(±) -2- [1- (3-Ethoxy-2-hydroxypropyl) -5-fluoro-1h-indo- ¹ "3-yl] -3- (5-fluoro-1H-indol-3-yl) -maleimide ;

(±)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5-hydroxy-lH-indol-3-yl]-3-(5-hydroxy-lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-ethoxy-2-hydroxypropyl) -5-hydroxy-lH-indol-3-yl] -3- (5-hydroxy-lH-indol-3-yl) maleimide;

(±)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5-trifluormethyl-lH-indol-3-yl]-3-(S-trifluormethyl-lH-indol-S-yl)-maleinimid;(±) -2- [l- (3-ethoxy-2-hydroxypropyl) -5-trifluoromethyl-lH-indol-3-yl] -3- (S-trifluoromethyl-lH-indol-S-yl) maleimide;

(±)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5-methoxy-lH-indol-3-yl]-3-(5-methoxy-lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-ethoxy-2-hydroxypropyl) -5-methoxy-lH-indol-3-yl] -3- (5-methoxy-lH-indol-3-yl) maleimide;

(±)-2-[l-(3-Ethoxy-2-hydroxypropyl)-4,5-methylendioxy-lH-indol-3-yl]-3-(4,S-methylendioxy-lH-indol-S-yl)-maleinimid;(±) -2- [l- (3-ethoxy-2-hydroxypropyl) -4,5-methylenedioxy-lH-indol-3-yl] -3- (4, S-methylenedioxy-lH-indol-S-yl ) maleimide;

(±)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5,6-methylendioxy-lH-indol-3-yl]-3-(5,6-methylendioxy-lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-ethoxy-2-hydroxypropyl) -5,6-methylenedioxy-lH-indol-3-yl] -3- (5,6-methylenedioxy-lH-indol-3-yl ) maleimide;

(±)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5-methyl-lH-indol-3-yl]~3-(5-methyl-lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-ethoxy-2-hydroxypropyl) -5-methyl-lH-indol-3-yl] ~ 3- (5-methyl-lH-indol-3-yl) maleimide;

(±)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5-nitro-lH-indol-3-yl]-3-(5-nitro-lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-ethoxy-2-hydroxypropyl) -5-nitro-lH-indol-3-yl] -3- (5-nitro-lH-indol-3-yl) maleimide;

(±)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5-methylthio-lH-indol-3-yl]-3-(5-methylthio-lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-ethoxy-2-hydroxypropyl) -5-methylthio-lH-indol-3-yl] -3- (5-methylthio-lH-indol-3-yl) maleimide;

-185--185-

(±)-2-[l-(3-Ethoxy-2-hydroxypropyl) ^,S-di yl]-3-(4,5-dimethoxy-lH-indol-3-yl)-maleijiimid;(±) -2- [1- (3-ethoxy-2-hydroxypropyl) -1, S -diyl] -3- (4,5-dimethoxy-1H-indol-3-yl) maleimide;

(±)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5,6-dimethoxy-lH-indol-3 yl]-3-(5,6-dimethoxy-lH-indol-3-yl)-maleinimid;(±) -2- [1- (3-Ethoxy-2-hydroxypropyl) -5,6-dimethoxy-1H-indol-3-yl] -3- (5,6-dimethoxy-1H-indol-3-yl) maleimide;

(+)-2-[5-Acetylamino-l-(3-ethoxy-2-hydroxypropyl)-iH-indol-3 .yl]-3-(5-acetylamino-lH-indol-3-yl)-maleinimid;(+) - 2- [5-Acetylamino-1- (3-ethoxy-2-hydroxypropyl) -iH-indole-3-yl] -3- (5-acetylamino-1H-indol-3-yl) -maleimide;

-2-[5-ATuino-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(5-amino-lH-indol-3-yl)-maleinimid;-2- [5-ATuino-l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -3- (5-amino-lH-indol-3-yl) maleimide;

2-[5-Benzyloxy-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(5-benzyloxy-lH-indol-3-yl)-maleinimid;2- [5-benzyloxy-l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -3- (5-benzyloxy-lH-indol-3-yl) maleimide;

(+)-2-[5-Brom-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(5-brom-lH-indol-3~yl)-maleiniinid;(+) - 2- [5-bromo-l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -3- (5-bromo-lH-indol-3 ~ yl) -maleiniinid;

(+)-2-[5-Chlor-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(5-chlor-lH-indol-3-yl)-maleinimid;(+) - 2- [5-chloro-l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -3- (5-chloro-lH-indol-3-yl) maleimide;

(+)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5-fluor-lH-indol-3-yl]-3-(5-fluor-lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-ethoxy-2-hydroxypropyl) -5-fluoro-lH-indol-3-yl] -3- (5-fluoro-lH-indol-3-yl) maleimide;

(5-hydroxy-lH-indol-3~yl)-maleinimid;(5-hydroxy-lH-indol-3 ~ yl) maleimide;

(+)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5-trifluormethyl-lH-indol-3-yl]-3-(ö-trifluormethyl-lH-indol-S-yl)-maleinimid;(+) - 2- [l- (3-ethoxy-2-hydroxypropyl) -5-trifluoromethyl-lH-indol-3-yl] -3- (o-trifluoromethyl-lH-indol-S-yl) maleimide;

(+)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5-methoxy-lH-indol-3-yl]-3-(5-methoxy-lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-ethoxy-2-hydroxypropyl) -5-methoxy-lH-indol-3-yl] -3- (5-methoxy-lH-indol-3-yl) maleimide;

(+)-2-[1-(3-Ethoxy-2-hydroxypropyl)-4,5-methylendioxy-lH-indol-3-yl]-3-(4,5-methylendioxy-lH-indol-3-yl)-maleinimid;(+) - 2- [1- (3-ethoxy-2-hydroxypropyl) -4,5-methylenedioxy-lH-indol-3-yl] -3- (4,5-methylenedioxy-lH-indol-3-yl ) maleimide;

(+)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5,6-methylendioxy-lH-indol-3-yl]-3-(5,e-methyiendioxy-lH-indol-S-yl)-maleinimid;(+) - 2- [l- (3-ethoxy-2-hydroxypropyl) -5,6-methylenedioxy-lH-indol-3-yl] -3- (5, e-methyiendioxy-lH-indol-S-yl ) maleimide;

-186--186-

(+)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5-TEGthyl-lH-ind?l-3-yl]-3 (5-methyl-lH-indol-3-yl)-maleinimid;(+) - 2- [1- (3-Ethoxy-2-hydroxypropyl) -5-TEGthyl-1H-indol-3-yl] -3 (5-methyl-1H-indol-3-yl) -maleimide ;

(+)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5-nitro-3.H-indol-3-yl]-3-(5-nitro~lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-ethoxy-2-hydroxypropyl) -5-nitro-3.H-indol-3-yl] -3- (5-nitro ~ lH-indol-3-yl) - maleimide;

(+)-2-tl-(3-Ethoxy-2-hydroxypropyl)-5-methylthio-lH-indol-3-.yl]-3-(5-methylthio-lH-indol-3-yl)-maleinimid;(+) - 2-tl (3-ethoxy-2-hydroxypropyl) -5-methylthio-lH-indol-3-.yl] -3- (5-methylthio-lH-indol-3-yl) maleimide;

(+)-2-[l-(3-Ethoxy-2-hydroxypropyl)-4,5-dimethoxy-lH-indol-3-yl]-3-(4,5-dimethoxy-lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-ethoxy-2-hydroxypropyl) -4,5-dimethoxy-lH-indol-3-yl] -3- (4,5-dimethoxy-lH-indol-3-yl ) maleimide;

-2-[l-(3-Ethoxy-2~hydroxypropyl) -5, 6-disiethoxy-lH-indol-3-yl]-3-(5,6-dimethoxy-lH-indol-3-yl)-maleinimid;-2- [1- (3-Ethoxy-2-hydroxypropyl) -5,6-disiethoxy-1H-indol-3-yl] -3- (5,6-dimethoxy-1H-indol-3-yl) -maleimide ;

(-)-2-[5-Acetylamino-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(S-acetylamino-lH-indol-S-yl)-maleinimid;(-) - 2- [5-Acetylamino-l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -3- (S-acetylamino-lH-indol-S-yl) maleimide;

(-)-2-[5-Amino-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(5-amino-lH-indol-3-yl)-maleinimid;(-) - 2- [5-Amino-l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -3- (5-amino-lH-indol-3-yl) maleimide;

(-)-2-[5-Benzyloxy-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(5~benzyloxy-lH-indol-3-yl)-maleinimid;(-) - 2- [5-benzyloxy-l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -3- (5 ~ benzyloxy-lH-indol-3-yl) maleimide;

(-)-2-[5-Brom-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(5-brom-lH-indol-3-yl)-maleinimid;(-) - 2- [5-bromo-l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -3- (5-bromo-lH-indol-3-yl) maleimide;

(-)-2-[5-Chlor-l-(3-ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(S-chlor-lH-indol-S-yl)-maleinimid;(-) - 2- [5-chloro-l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -3- (S-chloro-lH-indol-S-yl) maleimide;

(-)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5-fluor-lH-indol-3-yl]-3-(5-fluor-lH-indol-3-yl)-maleinimid;(-) - 2- [(3-ethoxy-2-hydroxypropyl) -5-fluoro-l-lH-indol-3-yl] -maleimide -3- (5-fluoro-lH-indol-3-yl);

(-)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5-hydroxy-lH-indol-3-yl]-3-(5-hydroxy-lH-indol-3-yl)-maleinimid;(-) - 2- [(3-ethoxy-2-hydroxypropyl) -5-hydroxy-l-lH-indol-3-yl] -maleimide -3- (5-hydroxy-lH-indol-3-yl);

(-)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5-trifluormethyl-lH-indol-3-yl]-3-(ö-trifluormethyl-lH-indol-S-yl)-maleinimid;(-) - 2- [(3-ethoxy-2-hydroxypropyl) -5-l- trifluoromethyl-lH-indol-3-yl] -maleimide -3- (o-trifluoromethyl-lH-indol-S-yl);

-187--187-

(-)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5-niethoxy~iH-iiidol-3-yl]-3-(5-methoxy-lH-indol-3-yl)-maleinimid;(-) - 2- [(3-ethoxy-2-hydroxypropyl) -5-niethoxy l- ~ iH-iiidol-3-yl] -maleimide -3- (5-methoxy-lH-indol-3-yl);

(-)-2-[l-(3-Ethoxy-2-hydroxypropyl)-4,5-methylendioxy-lH-indol-3-yij-3-(4,5-methylendioxy-lH-indol-3-yl)-maleinimid;(-) - 2- [l- (3-ethoxy-2-hydroxypropyl) -4,5-methylenedioxy-lH-indole-3-yij-3- (4,5-methylenedioxy-lH-indol-3-yl) maleimide;

(-)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5,6-methylendioxy-lH-indol-• 3-yl ] -3- (5, 6-methylendioxy-lH-indol-3-yl) -nialeinimid;(-) - 2- [1- (3-Ethoxy-2-hydroxypropyl) -5,6-methylenedioxy-1H-indol-3-yl] -3- (5,6-methylenedioxy-1H-indole-3-) yl) -nialeinimide;

(-)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5-methyl-lH-indol-3-yl]-3-(5-methyl-lH-indol-3-yl)-maleinimid;(-) - 2- [(3-ethoxy-2-hydroxypropyl) -5-methyl-l lH-indol-3-yl] -maleimide -3- (5-methyl-lH-indol-3-yl);

(-)-2-[l-(3-Ethoxy-2-hydroxypropyl)-5-nitro-lK-indol-3-yl]-3-(5-nitro-lH-indol-3-yl)-maleinimid;(-) - 2- [(3-ethoxy-2-hydroxypropyl) -5-nitro-l-lK-indol-3-yl] -maleimide -3- (5-nitro-lH-indol-3-yl);

(-)-2-[l-(3-Ethoxy-2-hydroxypropyl)-S-methylthio-lH-indol-S-yl]-3-(5-methylthio-lH-indol-3-yl)-maleinimid;(-) - 2- [(3-ethoxy-2-hydroxypropyl) l -S-methylthio-lH-indol-S-yl] -maleimide -3- (5-methylthio-lH-indol-3-yl);

(-)-2-[l-(3-Ethoxy-2-hydroxypropyl)-4,5-dimethoxy-lH-indol-3-yl]-3-(4,5-dimethoxy-lH-indol-3-yl)-maleinimid;[4,5-dimethoxy-lH-indol-3-yl l- (3-ethoxy-2-hydroxypropyl)] -3- (4,5-dimethoxy-lH-indol-3-yl 2 - (-) ) maleimide;

(-)-2-[l-(3«Ethoxy-2-hydroxypropyl)-5_/6-dimethoxy-lH-indol-3-yl]-3-(5,e-dimethoxy-lH-indol-S-yl)-maleinimid;(-) - 2- [1- (3 "ethoxy-2-hydroxypropyl) -5 _/ 6-dimethoxy-1H-indol-3-yl] -3- (5, e-dimethoxy-1H-indol-5-yl ) maleimide;

2-[5-Acet:ylamino-l-(2-diethylaminoethyl)-lH-indol-3-yl]-3-(5-acetylamino-lH-indol-3-yl)-maleinimid;2- [5-Acet: ylamino-l- (2-diethylaminoethyl) -lH-indol-3-yl] -3- (5-acetylamino-lH-indol-3-yl) maleimide;

2-[5 -Amino-1-(2-diethylaminoethyl)-lH-indol-3-yl]-3-(5-aminolH-indol-3-yl)-maleinimid;2- [5-amino-1- (2-diethylaminoethyl) -1H-indol-3-yl] -3- (5-amino-1H-indol-3-yl) -maleimide;

2-[5-Benzyloxy-l-(2-diethylaminoethyl)-lH-indol-3-yl]-3-(5-benzyloxy-lH-indol-3-yl)-maleinimid;2- [5-benzyloxy-l- (2-diethylaminoethyl) -lH-indol-3-yl] -3- (5-benzyloxy-lH-indol-3-yl) maleimide;

2-[5-Brom-l-(2-diethylaminoethyl)-lH-indol-3-yl]-3-(5-brom-lH-indol-3-yl)-maleinimid;2- [5-bromo-l- (2-diethylaminoethyl) -lH-indol-3-yl] -3- (5-bromo-lH-indol-3-yl) maleimide;

2-[5-Chlor-l-(2-diethylaminoethyl)-lH-indol-3-yl]-3-(5-chlorlH-indol-3-yl)-maleinimid;2- [5-chloro-l- (2-diethylaminoethyl) -lH-indol-3-yl] -3- (5-chlorlH-indol-3-yl) maleimide;

-188--188-

2- [1-(2-Diethylaminoethyl)-5-fluor-IH -indcl-3·yl]-3-(5 -fIu?rlH-indol-3-yl)-maleinlmid;2- [1- (2-diethylaminoethyl) -5-fluoro-1H-ind-3-yl] -3- (5-fluoroH-indol-3-yl) -maleimide;

2-[l-(2-Diethylaminoethyl)-5-hydroxy-lH-indol-3-yl]-3-(5-hyctroxy-lH-indol-3-yl)-maleinimid;2- [l- (2-diethylaminoethyl) -5-hydroxy-lH-indol-3-yl] -3- (5-hyctroxy-lH-indol-3-yl) maleimide;

2-[l-(2-Diethylaminoethyl)-5-trifluormethyl-lH-indol-3-yl]-3-• (S-trifluormethyl-lH-indol-S-yl)-maleinimid;2- [1- (2-diethylaminoethyl) -5-trifluoromethyl-1H-indol-3-yl] -3- (S-trifluoromethyl-1H-indol-5-yl) -maleimide;

2-[l-(2-Diethylaminoethyl)-5-methoxy-lH-indol-3-yl]-3-(5-methoxy-lH-indol-3-yl)-maleinimid;2- [l- (2-diethylaminoethyl) -5-methoxy-lH-indol-3-yl] -3- (5-methoxy-lH-indol-3-yl) maleimide;

2-[1-(2-Diethylaminoethyl)-4,5-methylendioxy-lH-indol-3-yl]-3-(4,5-methylendioxy-lH-indol-3-yl)-maleinimid;2- [1- (2-diethylaminoethyl) -4,5-methylenedioxy-lH-indol-3-yl] -3- (4,5-methylenedioxy-lH-indol-3-yl) maleimide;

2-[l-(2-Diethylaminoethyl)-5_/6-methylendioxy-lH-indol-i-yl]-3-(5, P- tnethylendioxy-lH-indol-3 -yl) -maleinimid;2- [1- (2-diethylaminoethyl) -5 _/ 6-methylenedioxy-1H-indol-1-yl] -3- (5, P -diethylenedioxy-1H-indol-3-yl) -maleimide;

2-[l-(2-Diethylaminoethyl)-5-methyl-lH-indol-3-yl]-3-(5-methyllH-indol-3-yl)-maleinimid;2- [l- (2-diethylaminoethyl) -5-methyllH-indole-3-yl] -3- (5-methyllH-indole-3-yl) maleimide;

2-[l-(2-Diethylaminoethyl)-5-nit;ro-lH-indol-3-yl]-3-(5-nitrolH-indol-3-yl)-maleinimid;2- [l- (2-diethylaminoethyl) -5-nit; ro-lH-indol-3-yl] -3- (5-nitrolH-indol-3-yl) maleimide;

2-[l-(2-Diethylaminoethyl)-5-methylthio-lH-indol-3-yl]-3-(5-methylthio-lH-indol-3-yl)-maleinimid;2- [l- (2-diethylaminoethyl) -5-methylthio-lH-indol-3-yl] -3- (5-methylthio-lH-indol-3-yl) maleimide;

2-[1-(2-Diethylaminoethyl)-4,S-dimethoxy-lH-indol-ß-yl]-3-(4,5-d.i.methoxy-lH-indol-3-yl) -maleinimid;2- [1- (2-diethylaminoethyl) -4, S -dimethoxy-1H-indol-.beta.-yl] -3- (4,5-di-methoxy-1H-indol-3-yl) -maleimide;

2-tl-(2-Diethylaminoethyl)-5,6-dimethoxy-lH-indol-3-yl]-3-(5_/6-dimethoxy-lH-indol-3-yl)-maleinimid;2-tl- (2-diethylaminoethyl) -5,6-dimethoxy-1H-indol-3-yl] -3- (5 _/ 6-dimethoxy-1H-indol-3-yl) -maleimide;

(±)-2-[5-Acetylamino-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(S-acetylamino-lH-indol-S-y].)-maleinimid?(±) -2- [5-acetylamino-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (S-acetylamino-lH-indol-S-y].) - maleimide?

(±)-2-[5-Amino-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(5-amino-lH-indol-3-yl)-maleinimid;(±) -2- [5-amino-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (5-amino-lH-indol-3-yl) maleimide;

-189--189-

(±)-2-[5-Benzyloxy-l-(3-diethylamino-2-hydro:r/propyl)-lH-indol~ 3-yl]-3-(S-benzyloxy-lH-indol-3-yl)-maleinimid;(±) -2- [5-Benzyloxy-1- (3-diethylamino-2-hydro: r / propyl) -1H-indol-3-yl] -3- (S-benzyloxy-1H-indol-3-yl ) maleimide;

(±)-2-[5-Brom-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-y1]-3-(5-brom-lH-indol-3-yl)-maleinimid;(±) -2- [5-bromo-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-y1] -3- (5-bromo-lH-indol-3-yl) maleimide;

(+)-2-[5-Chlor-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-• yl] -3·· (5-chlor-lH-indol-3-yl) -maleinimid;(+) - 2- [5-chloro-1- (3-diethylamino-2-hydroxypropyl) -1H-indol-3-yl] -3 ·· (5-chloro-1H-indol-3-yl) - maleimide;

(±)-2-[l-(3-Diethylamino-2-hydroxypropyl)-5-fluor-lH-indol-3-yl]-3-(5-fluor-lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-diethylamino-2-hydroxypropyl) -5-fluoro-lH-indol-3-yl] -3- (5-fluoro-lH-indol-3-yl) maleimide;

(±)-2~[l-(3-Diethylamino-2-hydroxypropyl)-5-hydroxy-lH-indol-3-yl]-3-(5-hydroxy-lH-indol-3-yl)-maleinimid;(±) -2 ~ [l- (3-diethylamino-2-hydroxypropyl) -5-hydroxy-lH-indol-3-yl] -3- (5-hydroxy-lH-indol-3-yl) maleimide;

(±)-2-[l-(3-Diethylamino-2"hydroxypropyl)-5-trifluormethyl-lH-indol-3-yl]-3-(5-trifluonaethyl-lH-indol-3-yl)-. <ualeinimid;(±) -2- [1- (3-Diethylamino-2-hydroxypropyl) -5-trifluoromethyl-1H-indol-3-yl] -3- (5-trifluoroethyl-1H-indol-3-yl) - ualeinimid;

(±)-2-[l-(3-Diethylamino-2-hydroxypropyi)-4,5-methylendioxy-lH-indol-3-yl]-3-(4,5-methylendioxy-lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-diethylamino-2-hydroxypropyl) -4,5-methylenedioxy-lH-indol-3-yl] -3- (4,5-methylenedioxy-lH-indol-3-yl ) maleimide;

(±)-2-[l-(3-Diethylamino-2-hydroxypropyl)-5,6-methylendioxy-lH-indol-3-yl]-3-(5,6-methylendioxy-lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-diethylamino-2-hydroxypropyl) -5,6-methylenedioxy-lH-indol-3-yl] -3- (5,6-methylenedioxy-lH-indol-3-yl ) maleimide;

(±)-2-[l-(3-Diethylamino~2-hydroxypropyl)-5-methyl-lH-indol-3-ylj-3-(5-methyl-IH-indol-3-yl)-maleinimid;(±) -2- [l- (3-diethylamino -2-hydroxypropyl) -5-methyl-lH-indol-3-YLJ-3- (5-methyl-IH-indol-3-yl) maleimide;

(±)-2-[l-(3-Diethylamino-2-hydroxypropyl)-5-nitro-lH-indol-3-yl]-3-(5-nitro-lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-diethylamino-2-hydroxypropyl) -5-nitro-lH-indol-3-yl] -3- (5-nitro-lH-indol-3-yl) maleimide;

(±)-2-[l-(3-Di'jthylamino-2-hydroxypropyl)-5-methylthio-lH-indol-3-yl] -3- (S-iaethylthio-lH-indol-3-yl) -maleinimid;(±) -2- [1- (3-Di'hylamino-2-hydroxypropyl) -5-methylthio-1H-indol-3-yl] -3- (S -ethylthio-1H-indol-3-yl) - maleimide;

(±)-2-[l-(3-Diethylamino-2-hydroxypropyl)-4_/5-dimethoxy-lH-indol-3-yl]-3-(4,S-dimethoxy-lH-indol-S-yl)-maleinimid;(±) -2- [1- (3-Diethylamino-2-hydroxypropyl) -4 _/ 5-dimethoxy-1H-indol-3-yl] -3- (4, 5-dimethoxy-1H-indol-5-yl ) maleimide;

(±)-2-[l-(3-Diethylamino-2-hydroxypropyl)-5,6-dimethoxy-lH-indol-3-yl]-3-(5,6-dimethoxy-lH-indol-3-yl)-maleinimid;(±) -2- [l- (3-diethylamino-2-hydroxypropyl) -5,6-dimethoxy-lH-indol-3-yl] -3- (5,6-dimethoxy-lH-indol-3-yl ) maleimide;

-2-[5-Acetylamino-l- (3-diethylaniino-2-hydroxypropyI) -IH-indol-3-yl]-3-(S-acetylamino-lH-indol-S-yl)-maleinimid;-2- [5-acetylamino-1- (3-diethylanino-2-hydroxypropyl) -1H-indol-3-yl] -3- (S-acetylamino-1H-indol-5-yl) -maleimide;

(+)-2-[5-Amino-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(5-amino-lH-indol-3~yl)-maleinimid;(+) - 2- [5-Amino-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (5-amino-lH-indol-3 ~ yl) maleimide;

(+)~2-[5-Benzyloxy-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-.3-yl]-3-(5-benzyloxy-lH-indol-3-yl)-maleinimid;(+) ~ 2- [5-benzyloxy-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-.3-yl] -3- (5-benzyloxy-lH-indol-3-yl) maleimide ;

(+)~2-[5-Brom-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(5-brom-lH-indol-3-yl)-maleinimid;(+) ~ 2- [5-bromo-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (5-bromo-lH-indol-3-yl) maleimide;

(+)-2-[5-Chlor-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(5-chlor-lH-indol-3-yl)-maleinimid;(+) - 2- [5-chloro-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (5-chloro-lH-indol-3-yl) maleimide;

(+)-2-[l-(3-Diethylamino-2-hydroxypropyl)-5-fluor-lH-indol-3-yl]-3-(5-fluor-lH-indol-3-yl)-maleiniraid;(+) - 2- [l- (3-diethylamino-2-hydroxypropyl) -5-fluoro-lH-indol-3-yl] -3- (5-fluoro-lH-indol-3-yl) -maleiniraid;

(+)-2-[l-(3-Diethylamino-2-hydroxypropyl)-S-hydroxy-lK-indol-S-yl]-3-(b-hydroxy-IH-indol-3-yl)-maleinimid;(+) - 2- [l- (3-diethylamino-2-hydroxypropyl) -S-hydroxy-lK-indol-S-yl] -3- (b-hydroxy-IH-indol-3-yl) maleimide;

(+)-2-[l-(3-Diethylamino-2-hydroxypropyl)-5-trifluormethyl-lH-indol-3-yl]-3-(S-trifluormethyl-lH-indol-S-yl)-maleinimid;(+) - 2- [l- (3-diethylamino-2-hydroxypropyl) -5-trifluoromethyl-lH-indol-3-yl] -3- (S-trifluoromethyl-lH-indol-S-yl) maleimide;

(+)-2-[i-(3-Diethylamino-2-hydroxypropyl) -•S-methoxy-lH-indol-S-yl]-3-(5-methoxy-lH-indol-3-yl)-maleinimid;(+) - 2- [i- (3-Diethylamino-2-hydroxypropyl) - • S -methoxy-1H-indol-S-yl] -3- (5-methoxy-1H-indol-3-yl) -maleimide ;

(+)-2-[l-(3-Diethylamino-2-hyc roxypropyl)-4,5-methylendioxy-lH-indol-3-yl]-3-(4,5-methylendioxy-lH-indol-3-yl)-maleinimid;(+) - 2- [1- (3-Diethylamino-2-hydroxypropyl) -4,5-methylenedioxy-1H-indol-3-yl] -3- (4,5-methylenedioxy-1H-indole-3-ol) yl) maleimide;

(+)-2-[l-(3-Diethylamino-2-hydroxypropyl)-5,6-methylendioxy-lH-indol-3-yl]-3-(5,ö-methylendioxy-lH-indol-S-yl)-maleinimid;(+) - 2- [l- (3-diethylamino-2-hydroxypropyl) -5,6-methylenedioxy-lH-indol-3-yl] -3- (5, ö-methylenedioxy-lH-indol-S-yl ) maleimide;

(+)~2-[l-(3-Diethylamino-2-hydroxypropyl)-5-methyl-lH-indol-3-yl]-3-(5-methyl-lH-indol-3-yl)-maleinimid;(+) ~ 2- [l- (3-diethylamino-2-hydroxypropyl) -5-methyl-lH-indol-3-yl] -3- (5-methyl-lH-indol-3-yl) maleimide;

(+)-2-[l-(3"Diethylamino-2-hydroxypropyl)-ö-nitro-lH-indol-S-yl]-3-(5-nitro-lH-indol-3-yl)-maleinimid;(+) - 2- [l- (3 "diethylamino-2-hydroxypropyl) -o-nitro-lH-indol-S-yl] -3- (5-nitro-lH-indol-3-yl) maleimide;

-191--191-

(+)~2-[l-(3-Diethylamino-2-hydroxypropyl)-5-nathylthio-IH-indol-3-yl]-3-(5-methylthio-lH-indol-3-yl)-maleini/aiu;(+) ~ 2- [l- (3-diethylamino-2-hydroxypropyl) -5-nathylthio-IH-indol-3-yl] -3- (5-methylthio-lH-indol-3-yl) -maleini / aiu;

(+)-2-[l-(3-Diethylamino-2-hydroxypropyl)-4_/5-dimethoxy-lH-indol-3-yl]-3-(4,5-dimethoxy-lH-indol-3-yl)-maleinimid;(+) - 2- [1- (3-Diethylamino-2-hydroxypropyl) -4 _/ 5-dimethoxy-1H-indol-3-yl] -3- (4,5-dimethoxy-1H-indol-3-yl ) maleimide;

(+)-2-[l-(3-Diethylamino-2-hydroxypropyl)-5_;6-dimethoxy-lH-indol-3-yl]-3-(5,6-dimethoxy-lH-indol-3-yl)-maleinimid;(+) - 2- [1- (3-diethylamino-2-hydroxypropyl) -5 _; 6-dimethoxy-lH-indol-3-yl] -3- (5,6-dimethoxy-lH-indol-3-yl) maleimide;

(-)-2--[5-Acetylamino-l-(3-diethylamino-2-hydroxypropy].)-lH-indol-3-yl]-3-(5-acetylamino-lH-indol-3-yl)-maleinimid;(-) - 2 - [5-acetylamino-l- (3-diethylamino-2-hydroxypropyl].) - lH-indol-3-yl] -3- (5-acetylamino-lH-indol-3-yl) maleimide;

(-)-2-[5-Amino-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(5-amino-lH-indol-3-yl)-maleinimid;(-) - 2- [5-Amino-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (5-amino-lH-indol-3-yl) maleimide;

(-)-2-[5-Benzyloxy-l-(3-diethylamino-2-hydroxypropyl)-l.H-indol-3-yl]-3-(S-benzyloxy-lH-indol-S-yl)-maleinimid,·(-) - 2- [5-benzyloxy-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (S-benzyloxy-lH-indol-S-yl) maleimide, ·

(-)-2- [5-Brom-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(5-brom-lH-indol-3-yl)-maleinimid;(-) - 2- [5-Bromo-1- (3-diethylamino-2-hydroxypropyl) -1H-indol-3-yl] -3- (5-bromo-1H-indol-3-yl) -maleimide;

(-)-2-[5-Chlor-l-(3-diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(S-chlor-lH-indol-S-yl)-maleinimid;(-) - 2- [5-chloro-l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (S-chloro-lH-indol-S-yl) maleimide;

(-)-2-[l-(3-Diethylamino-2-hydroxypropyl)-5-fluor-lH-indol-3-yl]-3-(5-fluor-lH-indol-3-yl)-maleinimid;(-) - 2- [(3-diethylamino-2-hydroxypropyl) -5-fluoro-l-lH-indol-3-yl] -maleimide -3- (5-fluoro-lH-indol-3-yl);

(-)-2-[l-(3-Diethylamino-2-hydroxypropyl)-5-hydroxy-lH-indol-3-yl]-3-(5-hydroxy-iH-indol-3-yl)-maleinimid;(-) - 2- [(3-diethylamino-2-hydroxypropyl) -5-hydroxy-l-lH-indol-3-yl] -maleimide -3- (5-hydroxy-iH-indol-3-yl);

(-)-2-[1-(3-Diethylaraino-2-hydroxypropy1)-5-trifluormethy1-IH-indol-3-yl]-3-(S-trifluormethyl-lH-indol-S-yl)-maleinimid;(-) - 2- [1- (3-Diethylaraino-2-hydroxypropy1) -5-trifluoromethy1-IH-indol-3-yl] -3- (S-trifluoromethyl-lH-indol-S-yl) maleimide;

(-)-2-[1-(3-Diethylamino-2-hydroxypropy1)-5-methoxy-lH-indol-3-yl]-3-(5-methoxy-lH-indol-3-yl)-maleinimid;(-) - 2- [1- (3-diethylamino-2-hydroxypropy1) -5-methoxy-lH-indol-3-yl] -3- (5-methoxy-lH-indol-3-yl) maleimide;

(-)-2-[l-(3-Diethylamino-2-hydroxypropyl)-4_/5-wethylendioxy-lH· indol-3-yl]-3-(4,5-methylendioxy-lH-indol-3-yl)-maleinimid; _{[-4/5-wethylendioxy-lH} · indol-3-yl l- (3-diethylamino-2-hydroxypropyl)] -3- (4,5-methylenedioxy-lH-indol-3-yl 2 - (-) ) maleimide;

-192--192-

(-)-2-[l-(3-Diethylamino-2-hydroxypropyl)-5_/6-methylenüioxy-lH-indol-3-yl]-3-(5,ö-methylendioxy-lH-indol-S-yl)-maleinimid;(-) - 2- [1- (3-Diethylamino-2-hydroxypropyl) -5 _/ 6-methylenioxy-1H-indol-3-yl] -3- (5, 6-methylenedioxy-1H-indol-5-yl ) maleimide;

(-)-2-[l-(3-Diethylamino-2-hydroxypropyl)-5-methyl-lH-indol-3-yl]-3-(5-methyl-lH-indol-3-yl)-maleinimid;(-) - 2- [(3-diethylamino-2-hydroxypropyl) -5-methyl-l lH-indol-3-yl] -maleimide -3- (5-methyl-lH-indol-3-yl);

(-)-2-[l-(3-Diethylamino-2-'hydroxypropyl)-5-nitro-lH-indol-3-•yl]-3-(5-nitro-lH-indol-3-yl)-maleinimid;(-) - 2- [l- (3-diethylamino-2-'hydroxypropyl) -5-nitro-lH-indol-3- • yl] -3- (5-nitro-lH-indol-3-yl) - maleimide;

(-)-2-[l-(3-Diethylamino-2-hydroxypropyl)-S-methylthio-lH-indol-3-yl]-3-(5-methylthio-lH-indol-3-yl)-maleinimid;(-) - 2- [(3-diethylamino-2-hydroxypropyl) l -S-methylthio-lH-indol-3-yl] -maleimide -3- (5-methylthio-lH-indol-3-yl);

(-)-2-[1-(3-Diethylamino-2-hydroxypropyl)-4_;5-dimethoxy-lH-indol-3-yl]-3-(4,5-dimethoxy-lH-indol-3-yl)-maleinimid;(-) -2- [1- (3-diethylamino-2-hydroxypropyl) -4 _; 5-dimethoxy-lH-indol-3-yl] -3- (4,5-dimethoxy-lH-indol-3-yl) maleimide;

(-)-2-[l-(3-Diethylaiaino-2-hydroxypropyl)-5,6-dimethoxy-lH-indol-3-yl]-3-(5,6-dimethoxy-lH-indol-3-yl)-maleinimid;[5,6-dimethoxy-lH-indol-3-yl l- (3-Diethylaiaino-2-hydroxypropyl)] -3- (5,6-dimethoxy-lH-indol-3-yl 2 - (-) ) maleimide;

2-[5-Acetylamino-l-(3-diethylaminopropyl)-lH-indol-3-yl]-3-(5-acetylamino-lH-indol-3-yl)-maleinimid;2- [5-Acetylamino-l- (3-diethylaminopropyl) -lH-indol-3-yl] -3- (5-acetylamino-lH-indol-3-yl) maleimide;

2-[5-Amino-l-(3-diethylaminopropyl)-lH-indol-3-ylj-3-(5-aminolH-indol-3-yl)-maleinimid;2- [5-Amino-l- (3-diethylaminopropyl) -lH-indol-3-YLJ-3- (5-aminolH-indol-3-yl) maleimide;

2-t5-Benzyloxy-l-(3-diethylaminopropyl)-lH-indol-3-yl]-3-(5-benzyloxy-l.H-indol-3-yl)-maleinimid;2-t5-benzyloxy-l- (3-diethylaminopropyl) -lH-indol-3-yl] -3- (5-benzyloxy-l.h-indol-3-yl) maleimide;

2-[5-Brom-l-(3-diethylaminopropyl)-iH-indol-3-yl]-3-(5-brom-lH-indol-3-yl)-maleinimid;2- [5-bromo-l- (3-diethylaminopropyl) -IH-indol-3-yl] -3- (5-bromo-lH-indol-3-yl) maleimide;

2-[5-Chlor-l-(3-diethylaminopropyl)-IH- indol-3-yl]-3-(5-chlorlH-indol-3-yl) -malei.aimid;2- [5-chloro-1- (3-diethylaminopropyl) -IH-indol-3-yl] -3- (5-chloro-H-indol-3-yl) -maleimide;

2-[l-(3-Diethylaminopropyl)-5-fluor-lH-indol-3-yl]-3-(5-fluorlH-indol-3-yl)-maleinimid;2- [l- (3-diethylaminopropyl) -5-fluorlH-indol-3-yl] -3- (5-fluorlH-indol-3-yl) maleimide;

2-[1-(3-Diethylaminopropyl)-S-hydroxy-lH-indol-S-yl]-3-(5-hydroxy-lH-indol-3-yl)-maleiniwid;2- [1- (3-diethylaminopropyl) -S-hydroxy-lH-indol-S-yl] -3- (5-hydroxy-lH-indol-3-yl) -maleiniwid;

-193--193-

2-[l-(3-Diethylaminopropyl)-5-trifluoinnethyl-lH-indol-3-yl]-3-(5-trifluormethyl-lH-indol-3-yl)-maleinimid;2- [l- (3-diethylaminopropyl) -5-trifluoinnethyl-lH-indol-3-yl] -3- (5-trifluoromethyl-lH-indol-3-yl) maleimide;

2-[l-(3-Diethylaminopropyl)-5-methoxy-lH-indol-3-yl]-3-(5-methoxy-lH-indol-3-yl)-maleinimid;2- [l- (3-diethylaminopropyl) -5-methoxy-lH-indol-3-yl] -3- (5-methoxy-lH-indol-3-yl) maleimide;

2-[l-(3-Diethylarainopropyl)-4,5-methylendioxy-lH-indol-3-yl]-3-•(4,S-methylendioxy-lH-indol-S-yl)-maleinimid;2- [l- (3-Diethylarainopropyl) -4,5-methylenedioxy-lH-indol-3-yl] -3- • (4, S-methylenedioxy-lH-indol-S-yl) maleimide;

2-[l-(3-Diethylaminopropyl)-5,6-methylendioxy-lH-indol-3-yl]-3-(5,6-methylendioxy-lH-indol-3-y1)-maleinimid;2- [l- (3-diethylaminopropyl) -5,6-methylenedioxy-lH-indol-3-yl] -3- (5,6-methylenedioxy-lH-indol-3-y1) maleimide;

2-[1-(3-Diethylaminopropyl)-5-methyl-lH-indol-3-y1]-3-(5-methyl-lH-indol-3-yl)-maleinimid;2- [1- (3-diethylaminopropyl) -5-methyl-lH-indol-3-y1] -3- (5-methyl-lH-indol-3-yl) maleimide;

2-[l-(3-Diethylaminopropyl)-5-nitro-lH-indol-3-yl]-3-(5-nitrolH-indol-3-yl)-maleinimid;2- [l- (3-diethylaminopropyl) -5-nitrolH-indol-3-yl] -3- (5-nitrolH-indol-3-yl) maleimide;

2-[l-(3-Diethylaminopropvl)-5-methylthio-lH-5.ndol-3-yl]-3-(5-methylthio-lH-indol-3-yl)-maleinimid;2- [l- (3-Diethylaminopropvl) -5-methylthio-lH-5.ndol-3-yl] -3- (5-methylthio-lH-indol-3-yl) maleimide;

2-[l-(3-Diethylaminopropyl)-4,5-dimethoxy-lH-indol-3-yl]-3-(4,5-dimethoxy-lH-indol-3-yl)-maleinimid;2- [l- (3-diethylaminopropyl) -4,5-dimethoxy-lH-indol-3-yl] -3- (4,5-dimethoxy-lH-indol-3-yl) maleimide;

2- [ 1- (3-Diethylaminopropyl) -5,6-dimethoxy-3.H-indol-3-yl ] -3-(5,6-dimethoxy-lH-indol-3-yl)-maleinimid;2- [1- (3-diethylaminopropyl) -5,6-dimethoxy-3H-indol-3-yl] -3- (5,6-dimethoxy-1H-indol-3-yl) -maleimide;

2-[5-Acetylamino-l-(3-ethylaminopropyl)-lH-indol-3-yl]-3-(5-acetylamino-lH-indol-3-yl)-maleinimid;2- [5-Acetylamino-l- (3-ethylaminopropyl) -lH-indol-3-yl] -3- (5-acetylamino-lH-indol-3-yl) maleimide;

2-[5-Amino-l-(3-ethylaminopropyl)-lH-indol-3-yl]-3-(5-amino-lH-indol-3-yl)-maleinimid;2- [5-Amino-l- (3-ethylaminopropyl) -lH-indol-3-yl] -3- (5-amino-lH-indol-3-yl) maleimide;

2-[5-Benzyloxy-l-(3-ethylaminopropyl)-lH-indol-3-yl]-3-(5-benzyloxy-lH-indol-3-yl)-maleinimid;2- [5-benzyloxy-l- (3-ethylaminopropyl) -lH-indol-3-yl] -3- (5-benzyloxy-lH-indol-3-yl) maleimide;

2-[5-Brom-l-_v3-ethylaminopropyl)-lH-indol-3-yl]-3-(5-brom-IH-indol-3-yl)-maleinimid;2- [5-bromo-l- _v 3-ethylaminopropyl) -lH-indol-3-yl] -3- (5-bromo-IH-indol-3-yl) maleimide;

-194--194-

2-[5-Chlor-l-(3-ethylaminopropyl)-lH-indol~3--yl]-3-(5-chlor-lH-indol-3-yl)-maleinimid;2- [5-chloro-l- (3-ethylaminopropyl) -lH-indol ~ 3 - yl] -3- (5-chloro-lH-indol-3-yl) maleimide;

2-tl-(3-Ethylaminopropyl)-5-fluor-lH-indol-3-yl]-3-(5-fluor-lH-indol-3-yl)-maleinimid;2-tl (3-ethylaminopropyl) -5-fluoro-lH-indol-3-yl] -3- (5-fluoro-lH-indol-3-yl) maleimide;

2-[l-(3-Ethylaminopropyl)-5-hydroxy-lH-indol-3-yl]-3-(5-.hydroxy-lH-indol-3-yl)-maleinimid;2- [l- (3-ethylaminopropyl) -5-hydroxy-lH-indol-3-yl] -3- (5-.hydroxy-lH-indol-3-yl) maleimide;

2-[1-(3-Ethylaminopropyl)-5-trifluormethyl-lH-indol-3-yl]-3-(5-trifluormethyl-lH-indol-3-yl)-maleinimid;2- [1- (3-ethylaminopropyl) -5-trifluoromethyl-lH-indol-3-yl] -3- (5-trifluoromethyl-lH-indol-3-yl) maleimide;

2-[l-(3-Ethylaminopropyl)-5-methoxy-lH-indol-3-yl]-3-(5-methoxy-lH-indol-3-yl)-maleinimid;2- [l- (3-ethylaminopropyl) -5-methoxy-lH-indol-3-yl] -3- (5-methoxy-lH-indol-3-yl) maleimide;

2-[1-(3-Ethylaminopropyl)-4,5-methylendioxy-lH-indol-3-yl]-3-(4,5-methylendioxy-lH-indol-3-yl)-maleinimid;2- [1- (3-ethylaminopropyl) -4,5-methylenedioxy-lH-indol-3-yl] -3- (4,5-methylenedioxy-lH-indol-3-yl) maleimide;

2-t1-(3-Ethylaminopropyl)-5,6-methylendioxy-lH-indol-3-yl]-3-(5,6-methylendioxy-lH-indol-3-yl)-maleinimid;2-t1- (3-ethylaminopropyl) -5,6-methylenedioxy-lH-indol-3-yl] -3- (5,6-methylenedioxy-lH-indol-3-yl) maleimide;

2-[l-(3-Ethylaminopropyl)-5-methyl-lH-indol-3-yl]-3-(5-methyllH-indol-3-yl)-maleinimid;2- [l- (3-ethylaminopropyl) -5-methyllH-indole-3-yl] -3- (5-methyllH-indole-3-yl) maleimide;

2-[1-(3-Ethylaminopropyl)-5-nitro-lH-indol-3-yl]-3-(5-nitro-lH-indol-3-yl)-maleinimid;2- [1- (3-ethylaminopropyl) -5-nitro-lH-indol-3-yl] -3- (5-nitro-lH-indol-3-yl) maleimide;

2-[l-(3-Ethylaminopropyl)-5-methylthio-lH-indol-3-yl]-3-(5-methylthio-lH-indol-3-yl)-maleinimid;2- [l- (3-ethylaminopropyl) -5-methylthio-lH-indol-3-yl] -3- (5-methylthio-lH-indol-3-yl) maleimide;

2-[1-(3-Ethylaminopropyl)-4,S-dimethoxy-lH-indol-S-yl]-3-(4,5-dimethoxy-lH-indol-3-yl)-maleinimid;2- [1- (3-ethylaminopropyl) -4, S-dimethoxy-lH-indol-S-yl] -3- (4,5-dimethoxy-lH-indol-3-yl) maleimide;

2-[l-(3-Ethylaminopropyl)-5,6-dimethoxy-IH-indol-3-yl]-3-(5,6-dimethoxy-lH-indol~3-yl)-maleinimid;2- [l- (3-ethylaminopropyl) -5,6-dimethoxy-IH-indol-3-yl] -3- (5,6-dimethoxy-lH-indol ~ 3-yl) maleimide;

(±)-2-[5-Acetylamino-l-(2-hydroxy-3-dimethylarainopropyl)-lH-indol-3-yl]-3-(5-acetylamino-lH-indol-3-yl)-maleinimid;(±) -2- [5-acetylamino-l- (2-hydroxy-3-dimethylarainopropyl) -lH-indol-3-yl] -3- (5-acetylamino-lH-indol-3-yl) maleimide;

-195--195-

(±)-2-[5-Amino-l-(2-hydroxy-3-dimechyiaminopropyl)-lH-indol-3-yl]-3-(5-amino-lH-indol-3-yl)-maleinimid;(±) -2- [5-amino-l- (2-hydroxy-3-dimechyiaminopropyl) -lH-indol-3-yl] -3- (5-amino-lH-indol-3-yl) maleimide;

(±)-2-[5-Benzyloxy-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(5-benzyloxy-lH-indol-3-yl)-maleinimid;(±) -2- [5-benzyloxy-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (5-benzyloxy-lH-indol-3-yl) maleimide;

(±)-2-[5-Brom-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-.yl]-3-(5-brom-lH-indol-3-yl)-maleinimid;(±) -2- [5-bromo-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-.yl] -3- (5-bromo-lH-indol-3-yl) maleimide ;

(±)-2-[5-Chlor-l-(2-hydroxy-3-dimethylaminopropyl)-iH-indol-3-yl]-3-(5-chlor-lH'indol-3-yl)-maleinimid;(±) -2- [5-chloro-l- (2-hydroxy-3-dimethylaminopropyl) -IH-indol-3-yl] -3- (5-chloro-lH'indol-3-yl) maleimide;

(±)- 2-[5-Fluor-1-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(5-fluor-lH-indol-3-yl)-maleinimid;(±) - 2- [5-Fluoro-1- (2-hydroxy-3-dimethylaminopropyl) -1H-indol-3-yl] -3- (5-fluoro-1H-indol-3-yl) -maleimide;

(±) -2- [5-Hydroxy-l-(2-hydroxy-3-diinethylaminopropy 1) -lH-indol-3-yl]-3"(5-hydroxy-lH-indol-3-yl)-maleinimid;(±) -2- [5-Hydroxy-1- (2-hydroxy-3-dimethylaminopropyl) -1H-indol-3-yl] -3 "(5-hydroxy-1H-indol-3-yl) -maleimide ;

(±)-2-[5-Trifluormethyl-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3~yl]-3-(5-trifluormethyl-lH-indol-3-yl)-maleinimid;(±) -2- [5-trifluoromethyl-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3 ~ yl] -3- (5-trifluoromethyl-lH-indol-3-yl) maleimide;

(±)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-5-methoxy-lH-indol-3-yl]-3-(5-methoxy-lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3-dimethylaminopropyl) -5-methoxy-lH-indol-3-yl] -3- (5-methoxy-lH-indol-3-yl) maleimide;

(±)-2-[l-(2-Hydroxy-3-dimethylaminopropy1)-4,5-methylendioxylH-indol-3-yl]-3-(4,5-methylendioxy-lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3-dimethylaminopropy1) -4,5-methylendioxylH-indol-3-yl] -3- (4,5-methylendioxylH-indol-3-yl) - maleimide;

(±)~2-[l-(2-Hydroxy-3-dimethylaminopropyl)-5,6-methylendioxylH-indol-3-yl]-3-(5,6-methylendioxy-lH-indol-3-yl)-maleinimid;(±) ~ 2- [l- (2-hydroxy-3-dimethylaminopropyl) -5,6-methylendioxylH-indol-3-yl] -3- (5,6-methylendioxylH-indol-3-yl) - maleimide;

(±)-2-[l-(2-Hydroxy-3-dimethylaH.inopropyl) -S-methyl-lH-indol-S-yl]-3-(5-methyl-lH-indol-3-yl)-maleinimid;(±) -2- [1- (2-Hydroxy-3-dimethyl-H, in-propyl) -S-methyl-1H-indol-S-yl] -3- (5-methyl-1H-indol-3-yl) - maleimide;

(±)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-5-nitro-lH-indol-3-yl]-3-(5-nitro-lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3-dimethylaminopropyl) -5-nitro-lH-indol-3-yl] -3- (5-nitro-lH-indol-3-yl) maleimide;

(±)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-5-methylthio-lH-indol-3-yi]-3-(5-methylthio--lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3-dimethylaminopropyl) -5-methylthio-lH-indol-3-yl] -3- (5-methylthio - lH-indol-3-yl) maleimide ;

J?9?.9?O -196- J? 9? .9? O -196-

(±)-2-[l-(2-Hydroxy-3-dimethylamir.opropyl)^4,5-dinäthcxy-lH-indol-3-yl]-3-(4,5-dimethoxy-lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3-dimethylamir.opropyl) ^ 4,5-dinäthcxy-lH-indol-3-yl] -3- (4,5-dimethoxy-lH-indol-3 -yl) maleimide;

(±)-2-[1-(2-Hydroxy-3-dimethylaminoprcpyl)-5,6-dimethoxy-lH-indol-3-yl]-3-(5,6-dimethoxy-lH-indol-3-yl)-maleinimid;(±) -2- [1- (2-Hydroxy-3-dimethylaminopyrphenyl) -5,6-dimethoxy-1H-indol-3-yl] -3- (5,6-dimethoxy-1H-indol-3-yl ) maleimide;

(+)-2-[5-Acetylamino-l-(2-hydroxy-3-dimethylaminopropyl)-IH-indol-3-yl]-3-(5-acf.!tylamino-lH-indol-3-yl) -maleinimid;(+) - 2- [5-Acetylamino-l- (2-hydroxy-3-dimethylaminopropyl) -IH-indol-3-yl] -3- (5-acf tylamino-lH-indol-3-yl.!) maleimide;

(+)-2-[5-Amino-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(5-amino-lH-indol-3-yl)-maleinimid;(+) - 2- [5-amino-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (5-amino-lH-indol-3-yl) maleimide;

(+)-2-[5-Benzyloxy-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(5-benzyloxy-lH-indol-3-yl)-maleinimid;(+) - 2- [5-benzyloxy-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (5-benzyloxy-lH-indol-3-yl) maleimide;

(+)-2-[5-Brom-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(3-brom-lH-indol-3-yl)-maleinimid;(+) - 2- [5-bromo-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (3-bromo-lH-indol-3-yl) maleimide;

(+)-2-[5-Chlor-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(5-chlor-lH-indol-3-yl)-maleinimid;(+) - 2- [5-chloro-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (5-chloro-lH-indol-3-yl) maleimide;

(+)-2-[5-Fluor-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(5-fluor-lH-indol-3-yl)-maleinimid;(+) - 2- [5-fluoro-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (5-fluoro-lH-indol-3-yl) maleimide;

(+)-2-[5-Hydroxy-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(5-hydroxy-lH-indol-3-yl)-maleinimid;(+) - 2- [5-hydroxy-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (5-hydroxy-lH-indol-3-yl) maleimide;

(+)-2-[5-Trifluormethyl-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(5-trifluormethyl-lH-indol-3-yl)-maleinimid;(+) - 2- [5-trifluoromethyl-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (5-trifluoromethyl-lH-indol-3-yl) maleimide;

(+)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-5-methoxy-lH-indol-3-yl]-3-(5-methoxy-lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3-dimethylaminopropyl) -5-methoxy-lH-indol-3-yl] -3- (5-methoxy-lH-indol-3-yl) maleimide;

(+)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-4,5-methylendioxylH-indol-3-yl]-3-(4,5-methylendioxy-lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3-dimethylaminopropyl) -4,5-methylendioxylH-indol-3-yl] -3- (4,5-methylendioxylH-indol-3-yl) - maleimide;

(+)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-5,6-methyiendioxylH-indol-3-yl]-3-(5,6-methylondioxy-lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3-dimethylaminopropyl) -5,6-methyiendioxylH-indol-3-yl] -3- (5,6-methylondioxy-lH-indol-3-yl) - maleimide;

(+)-2-Ll-(2-Hydroxy-3-dimethylaminopropyl)-5-methyl-lH-indol-3-yl]-3-(5-methyl-lH-indol-3-yl)-maleinimid;(+) - 2-Ll- (2-hydroxy-3-dimethylaminopropyl) -5-methyl-lH-indol-3-yl] -3- (5-methyl-lH-indol-3-yl) maleimide;

(+)-2-[1-(2-Hydroxy-3-dimethylaminopropyl)-ö-nitro-lH-indol-S-yl]-3-(5-nitro-lH-indol-3-yl)-maleinimid;(+) - 2- [1- (2-hydroxy-3-dimethylaminopropyl) -o-nitro-lH-indol-S-yl] -3- (5-nitro-lH-indol-3-yl) maleimide;

( *·) -2-[l-(2-Hydroxy-3-dimethylaminopropyl) -5-methylthio-lH-• indol-3-yl]-3-(5-methylthio-lH-indol-3-yl)-maleinimid;(* ·) -2- [1- (2-Hydroxy-3-dimethylaminopropyl) -5-methylthio-1H-indol-3-yl] -3- (5-methylthio-1H-indol-3-yl) - maleimide;

(+)-2-[1-(2-Hydroxy-3-dimethylaminopropyl)-4,5-dimethoxy-lH-indol-3-yl]-3-(4,5-dimethoxy-lH-indol-3-yl)-maleinimid;(+) - 2- [1- (2-hydroxy-3-dimethylaminopropyl) -4,5-dimethoxy-lH-indol-3-yl] -3- (4,5-dimethoxy-lH-indol-3-yl ) maleimide;

(+)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-5,6-dimethoxy-lH-indol-3-yl]-3-(5,6-dimethoxy-lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3-dimethylaminopropyl) -5,6-dimethoxy-lH-indol-3-yl] -3- (5,6-dimethoxy-lH-indol-3-yl ) maleimide;

(-)-2-[5-Acetylamino-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(5-acetylamino-lH-indol-3-yl)-maleiniinid;(-) - 2- [5-Acetylamino-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (5-acetylamino-lH-indol-3-yl) -maleiniinid;

(-)-2-[5-Amino-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(5-amino-lH-indol-3-yl)-maleinimid;(-) - 2- [5-amino-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (5-amino-lH-indol-3-yl) maleimide;

(-)-2-[5-Benzyloxy-l-(2-hydroxy-3-dimethylaminopropyl)-IH-indol-3-yl]-3-(5-benzyloxy-lH-indol-3-yl)-maleinimid;(-) - 2- [5-benzyloxy-l- (2-hydroxy-3-dimethylaminopropyl) -IH-indol-3-yl] -3- (5-benzyloxy-lH-indol-3-yl) maleimide;

(->-2-[5-Brom-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(5-brom-lH-indol-3-yl)-maleinimid;(-> - 2- [5-bromo-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (5-bromo-lH-indol-3-yl) maleimide;

(-)-2-[5-Chlor-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(S-chlor-lH-indol-S-yl)-maleinimid;(-) - 2- [5-chloro-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (S-chloro-lH-indol-S-yl) maleimide;

(-)-2-[5-Fluor-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(5-fluor-lH-indol-3-yl)-maleinimid;(-) - 2- [5-fluoro-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (5-fluoro-lH-indol-3-yl) maleimide;

(-)-2-[5-Hydroxy-l-(2-hydroxy-3-dimethylaminopropyl)-lH-indol-3-yl]-3-(5-hydroxy-lH-indol-3-yl)-maleinimid;(-) - 2- [5-hydroxy-l- (2-hydroxy-3-dimethylaminopropyl) -lH-indol-3-yl] -3- (5-hydroxy-lH-indol-3-yl) maleimide;

(-) -2-[5-Trifluormethyl-l-(2-hydroxy-3-dimethylavninopropyl) -IH-indol-3-yl]-3-(5-trifluormethyl-lH-indol-3-yl)-maleinimid;(-) -2- [5-Trifluoromethyl-1- (2-hydroxy-3-dimethyl-4-avinopropyl) -IH-indol-3-yl] -3- (5-trifluoromethyl-1H-indol-3-yl) -maleimide;

(-)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-5-methoxy-lH-indol-3-yl]-3-(5-methoxy-lH-indol-3-yl)-maleinimid;(-) - 2- [(2-hydroxy-3-dimethylaminopropyl) l- -5-methoxy-lH-indol-3-yl] -maleimide -3- (5-methoxy-lH-indol-3-yl);

(-)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-4,5-methylendioxylH-indol--3-yl]-3-(4,5-methylendioxy-lH-indol-3-yl)-maleinimid;(-) - 2- [l- (2-hydroxy-3-dimethylaminopropyl) -4,5-methylendioxylH-indol - 3-yl] -3- (4,5-methylendioxylH-indol-3-yl) maleimide;

(-)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-5,6-methylendioxy-' lH-indol-3-yl]-3-(5,6-methylendioxy-lH-indol-3-yl)-maleinimid;(-) - 2- [1- (2-Hydroxy-3-dimethylaminopropyl) -5,6-methylenedioxy-1H-indol-3-yl] -3- (5,6-methylenedioxy-1H-indole-3-one yl) maleimide;

(-)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-5-methyl-lH-indol-3 yl]-3-(5-methyl-lH-indol-3-yl)-maleinindd;(-) - 2- [1- (2-Hydroxy-3-dimethylaminopropyl) -5-methyl-1H-indol-3-yl] -3- (5-methyl-1H-indol-3-yl) -maleone;

(-)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-5-nitro-lH~indol-3-yl]-3-(5-nitro-lH-indol-3-yl)-maleinimid;(-) - 2- [(2-hydroxy-3-dimethylaminopropyl) -5-nitro-lH l- ~ indol-3-yl] -maleimide -3- (5-nitro-lH-indol-3-yl);

(-)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-5-methylthio-lH-indol-3-yl]-3-(5-methylthio-lH-indol-3-yl)-maleinimid;(-) - 2- [(2-hydroxy-3-dimethylaminopropyl) l- -5-methylthio-lH-indol-3-yl] -maleimide -3- (5-methylthio-lH-indol-3-yl);

(-)-2-[l-(2-Hydroxy-3-dimethylaminopropyl)-4,5-dimethoxy-lH-indol-3-yl]-3-(4,5-dimethoxy-lH-indol-3-yl)-maleinimid;(-) - 2- [l- (2-hydroxy-3-dimethylaminopropyl) -4,5-dimethoxy-lH-indol-3-yl] -3- (4,5-dimethoxy-lH-indol-3-yl ) maleimide;

(-) -2-[l-( 2-Hydroxy-3-dimethylaminopropyl) -5,6-dimet;hoxy-lH-indol-3-yl]-3-(5,6-dimethoxy-lH-indol-3-yl)-maleinimid;(-) -2- [1- (2-Hydroxy-3-dimethylaminopropyl) -5,6-dimethoxy-1H-indol-3-yl] -3- (5,6-dimethoxy-1H-indole-3 -yl) maleimide;

(±)-2-[5-Acetylamino-1-(2-hydroxy-3-(4-morpholino)propy1)-IH-indol-3-yl]-3-(5-acetylamino-lH-indol-3-yl)-maleinimid;(±) -2- [5-acetylamino-1- (2-hydroxy-3- (4-morpholino) propy1) -IH-indol-3-yl] -3- (5-acetylamino-lH-indol-3- yl) maleimide;

(±)-2-[5-Amino-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3 yl]-3-(5-amino-lH-indol-3-yl)-maleinimid;(±) -2- [5-Amino-1- (2-hydroxy-3- (4-morpholino) propyl) -1H-indol-3-yl] -3- (5-amino-1H-indol-3-yl ) maleimide;

(±)-2-[5-Benzyloxy-l-(2-hydroxy-3-(4-morpholino)propyl)-IH-indol-3-yl]-3-(5-benzyloxy-lH-indol-3-yl)-maleinimid;(±) -2- [5-benzyloxy-l- (2-hydroxy-3- (4-morpholino) propyl) -IH-indol-3-yl] -3- (5-benzyloxy-lH-indol-3- yl) maleimide;

(±) -2-[5-Brom-l-(2-hydrox5^-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(5-brom-iH-indol-3-yl)-maleinimid;(±) -2- [5-Bromo-1- (2-hydrox-5-3- (4-morpholino) propyl) -1H-indol-3-yl] -3- (5-bromo-iH-indole-3 -yl) maleimide;

(±)-2-[5-Chlor-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(5-chlor-lH-indol-3-yl)-maleinimid;(±) -2- [5-chloro-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (5-chloro-lH-indol-3- yl) maleimide;

-199--199-

(±)-2-[5-Fluor-l-(2-Hydroxy-3-(4-morpholino)propyl)-lH-indol-3 yl]-3-(5-fluor-lH-indol-3-yl)-maleinimid;(±) -2- [5-Fluoro-1- (2-hydroxy-3- (4-morpholino) propyl) -1H-indol-3-yl] -3- (5-fluoro-1H-indol-3-yl ) maleimide;

(±)-2-[5-Hydroxy-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol 3-yl]-3-(5-hydroxy-lH-indol-3-yl)-maleinimM;(±) -2- [5-Hydroxy-1- (2-hydroxy-3- (4-morpholino) propyl) -1H-indol-3-yl] -3- (5-hydroxy-1H-indol-3-yl ) -maleinimM;

( + )-2-[5-Trifluormethyl-l-(2-hydroxy-3-(4-morpholino)propyl) ' lH-indol-3-yl]-3-(5-trifluormethyl-lH-indol-3-yl)-maleinirjid;(+) -2- [5-Trifluoromethyl-1- (2-hydroxy-3- (4-morpholino) propyl) -1H-indol-3-yl] -3- (5-trifluoromethyl-1H-indole-3-) yl) -maleinirjid;

(±)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-5-methoxy-lH-indol-3-yl]-3-(S-methoxy-lH-indol-S-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3- (4-morpholino) propyl) -5-methoxy-lH-indol-3-yl] -3- (S-methoxy-lH-indole-S- yl) maleimide;

(±)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-4,5-methylendioxylH-indol-3-yl]-3-(4,5-methylendioxy-lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3- (4-morpholino) propyl) -4,5-methylendioxylH-indol-3-yl] -3- (4,5-methylendioxylH-indole 3-yl) maleimide;

(±)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-5,6-methylendioxylH-indol-3-yl]-3-(5,6-methylendioxy-lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3- (4-morpholino) propyl) -5,6-methylendioxylH-indol-3-yl] -3- (5,6-methylendioxylH-indole 3-yl) maleimide;

(±) -2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-5-methyl-lH-indol-3-yl]-3-(5-methyl-lH-indol-3-yl)-maleinimid;(±) -2- [1- (2-Hydroxy-3- (4-morpholino) propyl) -5-methyl-1H-indol-3-yl] -3- (5-methyl-1H-indole-3-) yl) maleimide;

(±)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-5-nitro-lH-indol-jyl]-3-(5-nitro-lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3- (4-morpholino) propyl) -5-nitro-lH-indol-jyl] -3- (5-nitro-lH-indol-3-yl) maleimide;

(+)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-5-methylthio-lH-indol-3-yl]-3-(5-methylthio-lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3- (4-morpholino) propyl) -5-methylthio-lH-indol-3-yl] -3- (5-methylthio-lH-indol-3- yl) maleimide;

( + )-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-4,5-d.imethoxy-lH-indol-3-yl]-3-(4,5-dimethoxy-lH-indol-3-yl)-maleinimid;(+) -2- [1- (2-Hydroxy-3- (4-morpholino) propyl) -4,5-dimethoxy-1H-indol-3-yl] -3- (4,5-dimethoxy) lH-indol-3-yl) maleimide;

(+)-2-[1-(2-Hydroxy-3-(4-morpholino)propyl)-5,6-dimethoxy-lH-indol-3-yl]-3-(5,6-dimethoxy-lH-indol-3-yl)-maleinimid;(+) - 2- [1- (2-hydroxy-3- (4-morpholino) propyl) -5,6-dimethoxy-lH-indol-3-yl] -3- (5,6-dimethoxy-LH indol-3-yl) maleimide;

(+)-2-[5-Acetylamino-l-(2-hydroxy-3-(4-morpholino)propyl)-IH-indol-3-yl]-3-(5-acetylamino-lH-indol-3-yl)-maleinimid;(+) - 2- [5-Acetylamino-l- (2-hydroxy-3- (4-morpholino) propyl) -IH-indol-3-yl] -3- (5-acetylamino-lH-indol-3- yl) maleimide;

(+)-2-[5-Amino-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3· yl]-3-(5-amino-lH-indol-3-yl)-maleiniaid;(+) - 2- [5-Amino-1- (2-hydroxy-3- (4-morpholino) propyl) -1H-indol-3-yl] -3- (5-amino-1H-indole-3-ol) yl) -maleiniaid;

-20C--20C-

(+)-2-[5-Benzyloxy-i-(2-hydroxy-3-(4-morpholino)propyi)-lH-indol-3-yl]-3-(5-benzyloxy-lH-indol-3-yl)-maleinimid;(+) - 2- [5-benzyloxy-i- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (5-benzyloxy-lH-indol-3- yl) maleimide;

(+)-2-[5-Brom-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(5-brom-lH-indol-3-y1)-maleinimid;(+) - 2- [5-bromo-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (5-bromo-lH-indol-3- y1) maleimide;

(+)-2-[5-Chlor-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-• yl]-3-(5-chlor-lH-indol-3-yl)-naleinimid;(+) - 2- [5-chloro-1- (2-hydroxy-3- (4-morpholino) propyl) -1H-indol-3-yl] -3- (5-chloro-1H-indole-3 -yl) -naleinimid;

(+)-2-[5-Fluor-l-(2-hydroxy-3-(4-morpholino)propyl)™lH-indol-3 · yl]-3-(5-fluor-lH-indol-3-yl)-maleinimid;(+) - 2- [5-Fluoro-1- (2-hydroxy-3- (4-morpholino) propyl) -1H-indol-3-yl] -3- (5-fluoro-1H-indole-3-) yl) maleimide;

(+)-2-[5-Hydroxy-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-..* 3-yl]-3-(5-hydroxy-lH-indol-3-yl)-maleinimid;(+) - 2- [5-Hydroxy-1- (2-hydroxy-3- (4-morpholino) propyl) -1H-indole -. * 3-yl] -3- (5-hydroxy-1H-indole -3-yl) maleimide;

(+)-2-[5-Trifluormethyl-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(5-trifluormethyl-lH-indol-3-yl)-maleinimid;(+) - 2- [5-trifluoromethyl-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (5-trifluoromethyl-lH-indol-3- yl) maleimide;

-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-5-methox^^r-lH-indol-3-yl]-3-(5-methoxy-lH-indol-3-yl)-maleinimid;-2- [l- (2-hydroxy-3- (4-morpholino) propyl) -5-Methox ^r ^ -lH-indol-3-yl] -3- (5-methoxy-lH-indol-3-yl ) maleimide;

(+)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-4_;5-methylendioxylH-indol-3-yl]-3-(4,5-methylendioxy-lH-i.ndol-3~yl)-maleinimid;(+) - 2- [1- (2-hydroxy-3- (4-morpholino) propyl) -4 _; 5-methylendioxylH-indol-3-yl] -3- (4,5-methylendioxylH-i.ndol-3 ~ yl) maleimide;

(+)-2-[1-(2-Hydroxy-3-(4-morpholino)propy1)-5,6-methylendioxylH-indol-3-yl]-3-(5,6-methylendioxy-lH-indol-3-yl)"7maleinimid;(+) - 2- [1- (2-hydroxy-3- (4-morpholino) propy1) -5,6-methylendioxylH-indol-3-yl] -3- (5,6-methylendioxylH-indole 3-yl) "7maleinimid;

(+)-2-[1-(2-Hydroxy-3-(4-morpholino)propyl)-5-methyl-lH-indol-3-yl]-3-(5-methyl-lH-indol-3-yl)-maleinimid;(+) - 2- [1- (2-hydroxy-3- (4-morpholino) propyl) -5-methyl-lH-indol-3-yl] -3- (5-methyl-lH-indol-3- yl) maleimide;

(+)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-5-nitro-lH-indol-3· yl]-3-(5-nitro-lH-indol-3-yl)-maleinimid;(+) - 2- [1- (2-Hydroxy-3- (4-morpholino) propyl) -5-nitro-1H-indol-3-yl] -3- (5-nitro-1H-indole-3-) yl) maleimide;

(+)-2-[1-(2-Hydroxy-3-(4-morpholino)propyl)-4,5-dimethoxy-lH-indol-3-yl]-3-(4,5-dimethoxy-lH-indol-3-yl)-maleinimid;(+) - 2- [1- (2-hydroxy-3- (4-morpholino) propyl) -4,5-dimethoxy-lH-indol-3-yl] -3- (4,5-dimethoxy-LH indol-3-yl) maleimide;

J9797D -20?.- J9797D -20? .-

(+)-2-[l-(2-Hydroxy-3-(4-morpholino)propel)-5,6-dimttnoxy-lH-indol-3-yl]-3-(5,ß-dimethoxy-lH-indol-S-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3- (4-morpholino) propel) -5,6-dimttnoxy-lH-indol-3-yl] -3- (5, ß-dimethoxy-LH indol-S-yl) maleimide;

i-) -z-[5-Acetylamino-l-(2-hydroxy-3-(4-morpholino)propyl)-IH-indol-3-yl]-3-(S-acetylamino-lH-indol-S-yl)-maleinimid; i-) -z- [5-Acetylamino-1- (2-hydroxy-3- (4-morpholino) propyl) -1H-indol-3-yl] -3- (S -acetylamino-1H-indole-5-yl) yl) maleimide;

(-)-2-[5-Amino-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-• yl]-3-(5-amino-lH-indol-3-yl)-maleinimid;(-) - 2- [5-Amino-1- (2-hydroxy-3- (4-morpholino) propyl) -1H-indol-3-yl] -3- (5-amino-1H-indole-3 -yl) maleimide;

(-)-2-[5-Benzyloxy-l-(2-hydroxy-3-(4~morpholino)propyl)-IH-indol-3-yl]-3-(5-benzyloxy-lH-indol-3-yl)-maleinimid;(-) - 2- [5-benzyloxy-l- (2-hydroxy-3- (4 ~ morpholino) propyl) -IH-indol-3-yl] -3- (5-benzyloxy-lH-indol-3- yl) maleimide;

(-)-2-[5-BrOm-I-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(5-brom-lH-indol-3-yl)-maleinimid;(-) - 2- [5-Bromo-I- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (5-bromo-lH-indol-3- yl) maleimide;

(-)-2-[5-Chlor-l-(2-hydroxy-3-(4-morpholino)propyl)-lH-indol-3-yl]-3-(5-chlor-lH-indol-3-yl)-maleinimid;(-) - 2- [5-chloro-l- (2-hydroxy-3- (4-morpholino) propyl) -lH-indol-3-yl] -3- (5-chloro-lH-indol-3- yl) maleimide;

;'-) -2-[5-Fluor-l-(2-hydroxy-3~(4-morpholino) propyl) -lH-indol-3-yl]-3-(5-fluor-lH-indol-3-yl)-maleinimid;; '-) -2- [5-Fluoro-1- (2-hydroxy-3 - (4-morpholino) propyl) -1H-indol-3-yl] -3- (5-fluoro-1H-indole-3 -yl) maleimide;

(-)-2-[5-Hydroxy-l-(2-hydroxy-3.-(4'Tmorpholino)propyl)-lH-indol-3-yl]-3-(5-hydroxy-lH-indol-3-yl)-maleinimid;(-) - 2- [5-hydroxy-l- (2-hydroxy-3 .- (4'Tmorpholino) propyl) -lH-indol-3-yl] -3- (5-hydroxy-lH-indol-3 -yl) maleimide;

(-) -2-[5-Trifluormethyl-l-(2--hydroxy-3-(4-morpholino)propyl) lH-indol-3-yl]-3·-(5-trifluormethy l-lH-indol-3-yl)-maleinimid ;(-) -2- [5-Trifluoromethyl-1- (2-hydroxy-3- (4-morpholino) propyl) -1H-indol-3-yl] -3 · - (5-trifluoromethyl-1H-indole) 3-yl) -maleimide;

(-)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-5-methoxy-lH-indol-3-yl]-3-(5-methoxy-lH-indol-3-yl)-maleinimid;(-) - 2- [l- (2-hydroxy-3- (4-morpholino) propyl) -5-methoxy-lH-indol-3-yl] -3- (5-methoxy-lH-indol-3- yl) maleimide;

(-)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)~4,5-methylendioxylK-indol-3-yl]-3-(4,5-methylendioxy-lH-"indol-3-yl)-maleinimid;(-) - 2- [l- (2-hydroxy-3- (4-morpholino) propyl) ~ 4,5-methylendioxylK-indol-3-yl] -3- (4,5-methylenedioxy-LH "indole -3-yl) maleimide;

(-)-2-[l-(2-Hydro;y-3-(4-morpholino)propyl)-5,6-methylendioxylH-indol-3-yl]-3-(5,6-methylendioxy-lH-indol-3-yl)-maleinimid;(-) - 2- [l- (2-hydro y-3- (4-morpholino) propyl) -5,6-methylendioxylH-indol-3-yl] -3- (5,6-methylenedioxy-LH indol-3-yl) maleimide;

(-)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-5-Methyl-lH-indol-3-yl]-3-(5-methyl-lH-indol-3-yl)-maleinimid;(-) - 2- [l- (2-hydroxy-3- (4-morpholino) propyl) -5-methyl-lH-indol-3-yl] -3- (5-methyl-lH-indol-3- yl) maleimide;

-202--202-

(-) -2-[l-(2-Hydroxy-3-(4-morpholinö)propyl)-b-nitro-ih-indol-3-yl]-3-(5-nitro-lH-indol-3-yl)-maleinimid;(-) -2- [1- (2-Hydroxy-3- (4-morpholino) propyl) -b-nitro-ih-indol-3-yl] -3- (5-nitro-1H-indole-3-) yl) maleimide;

(-)-2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-5-methylthio-lH-indol-3-yl]-3-(5-methylthio-lH-indol~3-yl)-maleinimid;(-) - 2- [l- (2-hydroxy-3- (4-morpholino) propyl) -5-methylthio-lH-indol-3-yl] -3- (5-methylthio-lH-indol ~ 3- yl) maleimide;

(-)~2-[l-(2-Hydroxy-3-(4-ff,orpholino)propyl)-4,5-dimethoxy-lH-•indol-3-yi]-3-(4,5-dimethoxy-lH-indol-3-yl)-maleinimid;(-) ~ 2- [l- (2-hydroxy-3- (4-ff, orpholino) propyl) -4,5-dimethoxy-LH • indol-3-yl] -3- (4,5-dimethoxy -lH-indol-3-yl) maleimide;

(-) -2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-5,6-dimethoxy-iH-indol-3-yl]-3-(5_;6-dimethoxy-lH-indol-3-yl)-maleinimid;(-) -2- [1- (2-Hydroxy-3- (4-morpholino) propyl) -5,6-dimethoxy-1H-indol-3-yl] -3- (5 _; 6-dimethoxy-1H- indol-3-yl) maleimide;

(±)-2-[5-Acetylamino-l-(2-hydroxy-3-(l-piperidino)propyl)-IH-indol-3-yl] -3- (5-&{:etylamino-lH-indol-3-yl) -maleinimid;(±) -2- [5-Acetylamino-1- (2-hydroxy-3- (1-piperidino) propyl) -1H-indol-3-yl] -3- (5 - &: - ethylamino-1H-indole 3-yl) -maleimide;

(±)-2-[5-Amino-l-(2-hydroxy-3-(l-pip8ridino)propyl)-lH-indol-3-yl]-3-(5-amino-lH-indol-3-yl)-maleinimid;(±) -2- [5-amino-l- (2-hydroxy-3- (l-pip8ridino) propyl) -lH-indol-3-yl] -3- (5-amino-lH-indol-3- yl) maleimide;

( + ) -2-[5-Benzyloxy-l-(2-hydroxy-3-(l-piperidino)propyl)-IH-indol-3-yl]-3-(5-benzyloxy-lH-indol-3-yl)-maleinimid;(+) -2- [5-Benzyloxy-1- (2-hydroxy-3- (1-piperidino) propyl) -1H-indol-3-yl] -3- (5-benzyloxy-1H-indole-3-ol yl) maleimide;

(±)-2-[5-Brom-l-(2-hydroxy-3-(l-piperidino)propyl)-lH-indol-3-yl]-3-(5-brom-lH-indol-3-yl)-maleinimid;(±) -2- [5-bromo-l- (2-hydroxy-3- (l-piperidino) propyl) -lH-indol-3-yl] -3- (5-bromo-lH-indol-3- yl) maleimide;

(±)-2-[5-Chlor-l-(2-hydroxy-3-(l-piperidino)propyl)-lH-indol-3-yl]-3-(5-chlor-lH-indol-3-yl)-maleinimid;(±) -2- [5-chloro-l- (2-hydroxy-3- (l-piperidino) propyl) -lH-indol-3-yl] -3- (5-chloro-lH-indol-3- yl) maleimide;

(±)-2-[5-Fluor-l-(2-hydroxy-3-(l-piperidino)propyl)-lH-indol-3-yl]-3-(5-fluor-lH-indol-3-yl)-maleinimid;(±) -2- [5-fluoro-l- (2-hydroxy-3- (l-piperidino) propyl) -lH-indol-3-yl] -3- (5-fluoro-lH-indol-3- yl) maleimide;

(±)-2-[5-Hydroxy-l-(2-hydroxy-3-(1-piperidino)propyl)-lH-indol-3-yl]-3-(5-hydroxy-lH-indol-3-yl)-maleinimid;(±) -2- [5-hydroxy-l- (2-hydroxy-3- (1-piperidino) propyl) -lH-indol-3-yl] -3- (5-hydroxy-lH-indol-3- yl) maleimide;

(±)-2-[5-Trifluormethyl-1-(2-hydroxy-3-(1-piperidino)propyl)~ lH-indol-3-yl]-3-(S-trifluormethyl-lH-indol-S-yl)-maleinimid;(±) -2- [5-Trifluoromethyl-1- (2-hydroxy-3- (1-piperidino) propyl) -1H-indol-3-yl] -3- (S-trifluoromethyl-1H-indole-S) yl) maleimide;

(±)-2-[l-(2-Hydroxy-3-(l-piperidino)propyl)-5-methoxy-lH-indol-3-yl]-3-(5-methoxy-lH~indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3- (l-piperidino) propyl) -5-methoxy-lH-indol-3-yl] -3- (5-methoxy-lH ~ indol-3- yl) maleimide;

(±) -2-·[ 1-(2-Hydroxy-3 -(1-piperidino)propyl) -4,5-methylendioxylH-indol-3-yl]-3-(4,5-methylendioxy-lH-indol-3-yl)-maleinimid;(±) -2- · [1- (2-Hydroxy-3- (1-piperidino) propyl) -4,5-methylenedioxyH-indol-3-yl] -3- (4,5-methylenedioxy-1H-indole -3-yl) maleimide;

(±)-2-[1-(2-Hydroxy-3-(1-piperidino)propyl)-5,6-methylendioxylH-indol-3-yl]-3-(5,6-methylendioxy-lH-indol-3-yl)-maleiniinid;(±) -2- [1- (2-hydroxy-3- (1-piperidino) propyl) -5,6-methylendioxylH-indol-3-yl] -3- (5,6-methylendioxylH-indole 3-yl) -maleiniinid;

(±)-2-[l-(2-Hydroxy-3-(l-piperidino)propyl)-5-methyl-lH-indol- 2-yl]-3-(5-methyl-lH-indol-3-yl)-maleinimid;(±) -2- [1- (2-Hydroxy-3- (1-piperidino) propyl) -5-methyl-1H-indol-2-yl] -3- (5-methyl-1H-indole-3-) yl) maleimide;

(+)-2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-S-nitro-lH-indol-3-yl]-3-(5-nitro-lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3- (1-piperidino) propyl) -S-nitro-lH-indol-3-yl] -3- (5-nitro-lH-indol-3- yl) maleimide;

(±)-2-[l-(2-Hydroxy-3-(l-piperidino)propyl)-5-methylthio-lH-indol-3-yl]-3-(5-methylthio-lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-hydroxy-3- (l-piperidino) propyl) -5-methylthio-lH-indol-3-yl] -3- (5-methylthio-lH-indol-3- yl) maleimide;

(+)-2-[1-(2-Hydroxy-3~(1-piperidino)propyl)-4,5-dimethoxy-lH-indol-3-yl]-3-(4,5-dimethoxy-lH-indol-3-yl)-maleinimid;(+) - 2- [1- (2-hydroxy-3 ~ (1-piperidino) propyl) -4,5-dimethoxy-lH-indol-3-yl] -3- (4,5-dimethoxy-LH indol-3-yl) maleimide;

(±)-2-[l-(2-Hydroxy-3-(1-piperidino)propyi)-5,6-dimethoxy-lH-i..dol-3-yl ] -3 - (5,6-dimethoxy-lH-indol-3 -yl) -maleinimid;(±) -2- [1- (2-Hydroxy-3- (1-piperidino) propyl) -5,6-dimethoxy-1H-i-diol-3-yl] -3- (5,6-dimethoxy -lH-indol-3-yl) -maleimide;

(+)-2-[5-Acetylamino-l-(2-hydroxy-3-(l-piperidino)propyl)-IH-indol-3-yl]-3-(S-acetylamino-lH-indol-S-yl)-maleinimid;(+) - 2- [5-Acetylamino-l- (2-hydroxy-3- (l-piperidino) propyl) -IH-indol-3-yl] -3- (S-acetylamino-lH-indol-S- yl) maleimide;

(+)-2-[5-Amino-l-(2-hydroxy-3-(l-piperidino)propyl)-lH-indol-3-yl]-3-(5-amino-lH-indol-3-yl)-maleinimid;(+) - 2- [5-amino-l- (2-hydroxy-3- (l-piperidino) propyl) -lH-indol-3-yl] -3- (5-amino-lH-indol-3- yl) maleimide;

(+)-2-[5-Benzyloxy-l-(2-hydroxy-3-(1-piperidino)propyl)-IH-indol-3-yl]-3-(5-benzyloxy-lH-indol-3-yl)-maleinimid;(+) - 2- [5-benzyloxy-l- (2-hydroxy-3- (1-piperidino) propyl) -IH-indol-3-yl] -3- (5-benzyloxy-lH-indol-3- yl) maleimide;

(+)-2-[5-Brom-l-(2-hydroxy-3-(1-piperidino)propyl)-lH-indol-3-yl]-3-(5-brom-lH-indol-3-yl)-maleinimid;(+) - 2- [5-bromo-l- (2-hydroxy-3- (1-piperidino) propyl) -lH-indol-3-yl] -3- (5-bromo-lH-indol-3- yl) maleimide;

(+)-2-[5-Chlor-l-(2-hydroxy-3-(1-piperidino)propyl)-lH-indol-3-yl]-3-(5-chlor-lH-indol-3-yl)-maleinimid;(+) - 2- [5-chloro-l- (2-hydroxy-3- (1-piperidino) propyl) -lH-indol-3-yl] -3- (5-chloro-lH-indol-3- yl) maleimide;

(+)-2-[5-Fluor-l-(2-hydroxy-3-(1-piperidino)propyl)-lH-indol-3· yl]-3-(5-fluor-lH-indol-3-yl)-maleinimid;(+) - 2- [5-Fluoro-1- (2-hydroxy-3- (1-piperidino) propyl) -1H-indol-3-yl] -3- (5-fluoro-1H-indole-3-) yl) maleimide;

-2M--2M-

(+)-2-[5-Hydroxy-l-(2~hydroxy-3-(1-piperidino)propyl)-lH-indol-3-yl]-3-(5-hydroxy-lH-indol-3-yl)-maleinimid;(+) - 2- [5-hydroxy-l- (2 ~ hydroxy-3- (1-piperidino) propyl) -lH-indol-3-yl] -3- (5-hydroxy-lH-indol-3- yl) maleimide;

(+)-2-[5-Trifluormethyl-1-(2-hydroxy-3-(1-piperidino)propyl) lH-indol-3-yl]-3-(5-trifluormethyl-lH-indol-3-yl)-maleinimid;(+) - 2- [5-Trifluoromethyl-1- (2-hydroxy-3- (1-piperidino) propyl) -1H-indol-3-yl] -3- (5-trifluoromethyl-1H-indol-3-yl ) maleimide;

(+)-2-[1-(2-Hydroxy-3-(1-piperidino)propyl)-5-methoxy-lH-indol-3-yl]-3-(5-methoxy-lH-indol-3-yl)-maleinimid;(+) - 2- [1- (2-hydroxy-3- (1-piperidino) propyl) -5-methoxy-lH-indol-3-yl] -3- (5-methoxy-lH-indol-3- yl) maleimide;

(+)-2-[1-(2-Hydroxy-3-(1-piperidino)propyl)-4,5-methylendioxylH-indol-3-yl]-3-(4,5-methylendioxy-lH-indol-3-yl)-maleinimid;(+) - 2- [1- (2-hydroxy-3- (1-piperidino) propyl) -4,5-methylendioxylH-indol-3-yl] -3- (4,5-methylendioxylH-indole 3-yl) maleimide;

(+)-2-[1-(2-Hydroxy-3-(1-piperidino)propyl)-5,6-methylendioxylH-indol-3-yl]-3-(5,6-methylendioxy-lH-indol-3-yl)-maleinimid;(+) - 2- [1- (2-hydroxy-3- (1-piperidino) propyl) -5,6-methylendioxylH-indol-3-yl] -3- (5,6-methylendioxylH-indole 3-yl) maleimide;

(+)-2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-5-methyl-lH-indol-3-yl] -3- (5-methyl-lH-indol-3-yl) -maleiniinid;(+) - 2- [1- (2-Hydroxy-3- (1-piperidino) propyl) -5-methyl-1H-indol-3-yl] -3- (5-methyl-1H-indole-3-) yl) maleiniinide;

(+)-2-[l-(2-Hydroxy-3-(1-piperidino)propy1)-5-nitro-lH-indol-3-yl]-3-(5-nitro-lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3- (1-piperidino) propy1) -5-nitro-lH-indol-3-yl] -3- (5-nitro-lH-indol-3- yl) maleimide;

(+)-2-[l-(2-Hydroxy-3-(l-piperidino)propyl)-5-raethylthio-lH-indol-3-yl]-3-(5-methylthio-lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3- (l-piperidino) propyl) -5-raethylthio-lH-indol-3-yl] -3- (5-methylthio-lH-indol-3- yl) maleimide;

(+)-2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-4,5-dimethoxy-lH-indol-3-yl]-3-(4,5-dimethoxy-lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-hydroxy-3- (1-piperidino) propyl) -4,5-dimethoxy-lH-indol-3-yl] -3- (4,5-dimethoxy-LH indol-3-yl) maleimide;

(+)-2-[1-(2-Hydroxy-3-(1-piperidino)propyl)-5,6-dimethoxy-lH-indol-3-yl]-3-(5,6-dimethoxy-lH-indol-3-yl)-maleinimid;(+) - 2- [1- (2-hydroxy-3- (1-piperidino) propyl) -5,6-dimethoxy-lH-indol-3-yl] -3- (5,6-dimethoxy-LH indol-3-yl) maleimide;

(-)-2-[5-Acetylamino-l-(2-hydroxy-3~(1-piperidino)propyl)-IH-indol-3-yl]-3-(5-acetylamino-lH-indol-3-yl)-maleinimid;(-) - 2- [5-Acetylamino-l- (2-hydroxy-3 ~ (1-piperidino) propyl) -IH-indol-3-yl] -3- (5-acetylamino-lH-indol-3- yl) maleimide;

(-)-2-[5-Amino-l-(2-hydroxy-3-(1-piperidino)propyl)-lH-indol-3-ylJ-3-(5-amino-lH-indol-3-yl)-maleinimid;(2-hydroxy-3- (1-piperidino) propyl) -lH-indole-3-YLJ-3- (5-amino-lH-indol-3-yl 2- [5-Amino-l- (-) - ) maleimide;

(-)-2-[5-Benzyloxy-l-(2-hydroxy-3-(l-piperidino)propyl)-IH-indol-3-yl]-3-(5-benzyloxy-lH-indol-3-yl)-maleinimidi(-) - 2- [5-benzyloxy-l- (2-hydroxy-3- (l-piperidino) propyl) -IH-indol-3-yl] -3- (5-benzyloxy-lH-indol-3- yl) -maleinimidi

-205--205-

(-)-2-[5-Brom-l-(2-hydroxy-3-(l-piparidino)propyl)-lH-indol-3-yl]-3-(5-brom-lH-indol-3-yl)-maleinimid;(-) - 2- [5-bromo-l- (2-hydroxy-3- (l-piparidino) propyl) -lH-indol-3-yl] -3- (5-bromo-lH-indol-3- yl) maleimide;

(-)-..-[5-Chlor-l-( 2-hydroxy-3-( 1-piperidino) propyl )-lH-indol-3-yl]-3-(5-chlor-lH-indol-3-yl)-maleinimid;(-) - - [5-Chloro-1- (2-hydroxy-3- (1-piperidino) propyl) -1H-indol-3-yl] -3- (5-chloro-1H-indole-3 -yl) maleimide;

(-)-2-[5-Fluor-l-(2-hydroxy-3-(l-piperidino)propyl)-lH-indol-3-•yl]-3-(5-fluor-lH-indol-3-yl)-maleinimid;(-) - 2- [5-fluoro-l- (2-hydroxy-3- (l-piperidino) propyl) -lH-indole-3 • yl] -3- (5-fluoro-lH-indol-3 -yl) maleimide;

(-)-2-[5-Hydroxy-l-(2-hydroxy-3-(1-piperidino)propyl)-lH-indol-3-yl]-3-(5-hydroxy-lH-indol-3-yl)-maleinimid;(-) - 2- [5-hydroxy-l- (2-hydroxy-3- (1-piperidino) propyl) -lH-indol-3-yl] -3- (5-hydroxy-lH-indol-3- yl) maleimide;

(-)-2-[5-Trifluormethyl-l-(2-hydroxy-3-(l-piperidino)propyl)-lH-indol-3-yl]-3-(5-trifluormethyl-lH-indol-3-yl)-maleinimid;(-) - 2- [5-trifluoromethyl-l- (2-hydroxy-3- (l-piperidino) propyl) -lH-indol-3-yl] -3- (5-trifluoromethyl-lH-indol-3- yl) maleimide;

(-) -2-[1-(2-Hydroxy-3-(1-piperidino)propyl)-5-methoxy-lH-indol-3-yl]-3-(5-iaethoxy-lH-indol-3-yl)-maleinimid;(-) -2- [1- (2-Hydroxy-3- (1-piperidino) propyl) -5-methoxy-1H-indol-3-yl] -3- (5-iaethoxy-1H-indole-3-) yl) maleimide;

(-) -2- [l-(2-Hydroxy-3- (1-piperidino) propyl) -6-inethoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid?(-) -2- [1- (2-Hydroxy-3- (1-piperidino) propyl) -6-methoxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide ?

(-)-2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-4,5-methylendioxylH-indol-3-yl]-3-(4_;5-methylendioxy-lH-indol-3-yl)-maleinimid;(-) - 2- [1- (2-Hydroxy-3- (1-piperidino) propyl) -4,5-methylenedioxylH-indol-3-yl] -3- (4 _; 5-methylenedioxy-1H-indole) 3-yl) maleimide;

(-)-2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-5,6-methylendioxylH-indol-3-yl]-3-(5,6-methylendioxy-:.H-indol-3-vl)-maleinimid;(-) - 2- [l- (2-hydroxy-3- (1-piperidino) propyl) -5,6-methylendioxylH-indol-3-yl] -3- (5,6-methylenedioxy - H- :. indol-3-yl) maleimide;

(-)-2-[l-(2-Hydroxy-3- (1-piperidino) propyl) -5-inethyl-lH-indol-3-yl]-3-(5-methyl-lH-indol-3-yl)-maleinimid;(-) - 2- [1- (2-Hydroxy-3- (1-piperidino) propyl) -5-ethyl-1H-indol-3-yl] -3- (5-methyl-1H-indole-3-) yl) maleimide;

(-)-2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-S-nitro-lH-indol-S-yl]-3-(5-nitro-lH-indol-3-yl)-maleinimid;(-) - 2- [l- (2-hydroxy-3- (1-piperidino) propyl) -S-nitro-lH-indol-S-yl] -3- (5-nitro-lH-indol-3- yl) maleimide;

(-)-2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-5-methylthio-lK-indol-3-yl]-3-(5-aethylthio-lH-indol-3-yl)~maleinimid;[((2-hydroxy-3- 1-piperidino) propyl) -5-methylthio-l-lK-indol-3-yl] 2- -3- (5-ethylthio-lH-indole-3 - (-) yl) ~ maleimide;

(-)-2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-4,5-dimethoxy-IH-indol-3-yl]-3-(4,5-dimethoxy-lH-indol-3-yl)-maleinimid;(-) - 2- [l- (2-hydroxy-3- (1-piperidino) propyl) -4,5-dimethoxy-IH-indol-3-yl] -3- (4,5-dimethoxy-LH indol-3-yl) maleimide;

(-)-2 -[1-(2-Hydroxy-3-(1-piperidino)propyl)-5,6-dimethoxy-lH-indol-3-yl] -·3- (5, 6-dimethoxy-lH-indol-3-yl) -maleinimid;(-) - 2 - [1- (2-Hydroxy-3- (1-piperidino) propyl) -5,6-dimethoxy-1H-indol-3-yl] -. 3- (5,6-dimethoxy-1H indol-3-yl) -maleimide;

(±)-2-Γ5-Acetylamino-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(5-acetylamino-lH-indol-3-yl)-maleinimid;(±) -2-acetylamino-Γ5-L- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (5-acetylamino-lH-indol-3-yl) maleimide;

(±)-2-t5-Amino-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(5-• amino-lH-indol-3-yl)-maleinimid;(±) -2-t5-amino-1- (2,3-dihydroxypropyl) -1H-indol-3-yl] -3- (5-amino-1H-indol-3-yl) -maleimide;

(±)-2-[ 5-Benzyloxy-l-(2,'i-dihydroxypropyl)-lH-indol-3-yl]-3-(5-benzyloxy-lH-indol-3-yl)-maleinimid;(±) -2- [5-Benzyloxy-1- (2,1'-dihydroxypropyl) -1H-indol-3-yl] -3- (5-benzyloxy-1H-indol-3-yl) -maleimide;

(±)-2-[5-Brom-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]--3-(5-brom· lH-indol-3-yl)-maleinimid;(±) -2- [5-bromo-1- (2,3-dihydroxypropyl) -1H-indol-3-yl] -3- (5-bromo-1H-indol-3-yl) -maleimide;

(±)-2-[5-Chlor-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(5-chlor-lH-indol-3-yl)-maleinimid;(±) -2- [5-chloro-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (5-chloro-lH-indol-3-yl) maleimide;

(±)-2-[5-Fluor-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(5-fluor-lH-indol-3-yl)-maleinimLd;(±) -2- [5-fluoro-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (5-fluoro-lH-indol-3-yl) -maleinimLd;

(±)-2-[5-Hydroxy-l-(2_/3-dihydroxypropyl)-lH-indol-3-yl]-3-(5-hydroxy-lH-indol-3-yl)-maleinimid;(±) -2- [5-hydroxy-1- (2 _/ 3-dihydroxypropyl) -1H-indol-3-yl] -3- (5-hydroxy-1H-indol-3-yl) -maleimide;

(±)-2-[5-Trifluormethyl-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]· 3-(S-trifluormethyl-lH-indol-S-yl)-maleinimid;(±) -2- [5-trifluoromethyl-1- (2,3-dihydroxypropyl) -1H-indol-3-yl] .3- (S-trifluoromethyl-1H-indol-S-yl) -maleimide;

(±)-2-[l-(2,3-Dihydroxypropyl)-5-methoxy-lH-indol-3-ylJ-3-(5-me.thoxy-lH-indol-3-yl) -maleinimid;(±) -2- [1- (2,3-dihydroxypropyl) -5-methoxy-1H-indol-3-ylJ-3- (5-me.thoxy-1H-indol-3-yl) -maleimide;

(±)-2-[1-[2, 3-Dihydroxypropyl)-4,5-methylendioxy-lH-indol-3~ yl]-3-(4,5-methylendioxy-lH-indol-3-yl)-maleinimid;(±) -2- [1- [ 2,3-Dihydroxypropyl) -4,5-methylenedioxy-1H-indol-3-yl] -3- (4,5-methylenedioxy-1H-indol-3-yl) - maleimide;

(±)-2-[l-(2,3-Dihydroxypropyl)-5,6-methylendioxy-lH-indol-3-yl]-3-(5,6-methylendioxy-lH-indol-3-yl)-maleinimid;(±) -2- [l- (2,3-dihydroxypropyl) -5,6-methylenedioxy-lH-indol-3-yl] -3- (5,6-methylenedioxy-lH-indol-3-yl) - maleimide;

(±)-2-[l-(2,3-Dihydroxypropyl)-5-methyl-lH-indol-3-yl]-3- (5-methy.l-lH-indol-3-yl)-maleinimid;(±) -2- [1- (2,3-dihydroxypropyl) -5-methyl-1H-indol-3-yl] -3- (5-methyl-1H-indol-3-yl) -maleimide;

-207--207-

(±)-2-[l-(2,3-Dihydroxypropyl)-5-nitro-lH-indol-3-yl]-3-(5-nitro-iH-indol-3-yl)-maleinimid;(±) -2- [l- (2,3-dihydroxypropyl) -5-nitro-lH-indol-3-yl] -3- (5-nitro-IH-indol-3-yl) maleimide;

(±) -2-[l-(2,3-Dihydroxypropyl)-5-methylthio-lH-indol-3-yl]-3-(5-methylthio-lH-indol-3-yl)-maleinimid;(±) -2- [1- (2,3-dihydroxypropyl) -5-methylthio-1H-indol-3-yl] -3- (5-methylthio-1H-indol-3-yl) -maleimide;

(±)-2-[l-(2,3-Dihydroxypropyl)-4,5-dimethoxy-lH-indol-3-yl]-3-• (4,5-dimethoxy-;lH-indol-3-yl)-inaleinimid;(±) -2- [1- (2,3-Dihydroxypropyl) -4,5-dimethoxy-1H-indol-3-yl] -3- • (4,5-dimethoxy; 1H-indol-3-yl ) -inaleinimid;

(±)-2-[1-(2,3-Dihydroxypropyl)-5,6-dimethoxy-lH-indol-3-yl]-3-(5,6-dimethoxy-lH-indol-3-yl) -maleiniicid;(±) -2- [1- (2,3-Dihydroxypropyl) -5,6-dimethoxy-1H-indol-3-yl] -3- (5,6-dimethoxy-1H-indol-3-yl) - maleiniicid;

(+)-2-[5-Acetylamino-l-(2,3-dihydroxypropyl)-lK-indol-3-yl]-3-(5-acetylamino-lH-indol-3-yl)-maleinimid;(+) - 2- [5-Acetylamino-l- (2,3-dihydroxypropyl) -LK-indol-3-yl] -3- (5-acetylamino-lH-indol-3-yl) maleimide;

(+)-2-[5-Amino-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(5-amino-lH-indol-3-yl) -iaaleinimid;(+) - 2- [5-amino-1- (2,3-dihydroxypropyl) -1H-indol-3-yl] -3- (5-amino-1H-indol-3-yl) -alAlimide;

(+)-2-[5-Benzyloxy-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(5-benzyloxy-lH-indol-3-yl)-waleinimiri?(+) - 2- [5-benzyloxy-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (5-benzyloxy-lH-indol-3-yl) -waleinimiri?

(+)-2-[5-Brom-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(5-bromlH-indol-3-yl)-maleinimid;(+) - 2- [5-bromo-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (5-bromlH-indol-3-yl) maleimide;

(+)-2-[5-Chlor-l-(2,J-dihydroxypropyl)-lH-indol-3-y?]-3-(5-chlor-lH-indol-3-yl)-maleinimid;(+) - 2- [5-chloro-l- (2, J-dihydroxypropyl) -lH-indol-3-y!] - 3- (5-chloro-lH-indol-3-yl) maleimide;

(+)-2-[5-Fluor-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(5-fluor~lH-indnl-3-yl)-maleinimid;(+) - 2- [5-fluoro-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (5-fluoro-lH ~ indnl-3-yl) maleimide;

(+)~2-[5-Hydroxy-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(5-hydroxy-lH-indol-3-yl)-maleinimid?(+) ~ 2- [5-Hydroxy-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (5-hydroxy-lH-indol-3-yl) maleimide?

(+)-2-[5-Trifluormethyl-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-'J-(S-trifluormethyl-lH-indol-S-yl)-maleinimid;(+) - 2- [5-trifluoromethyl-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] - 'J- (S-trifluoromethyl-lH-indol-S-yl) maleimide;

(+)-2-[l-(2,3-Dihydroxypropyl)-5-methoxy-lH-indol-3-yl]-3-(5-methoxy-lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2,3-dihydroxypropyl) -5-methoxy-lH-indol-3-yl] -3- (5-methoxy-lH-indol-3-yl) maleimide;

-208--208-

(+)-2- [1-(2,3-Dihydroxypropyl)-4,5-methylendioxy-lH-indol-3-yl]-3-(4,S-methylendioxy-lH-indol-S-yl)-maleinimid;(+) - 2- [1- (2,3-Dihydroxypropyl) -4,5-methylenedioxy-1H-indol-3-yl] -3- (4, 5-methylenedioxy-1H-indol-5-yl) - maleimide;

(+)-2-[l-(2,3-Dihydroxypropyl)-5,6-methylendioxy-lH-indol-3-yl]-3-(5,6-methylendioxy-lH-indol~3-yl)-maleinimid;(+) - 2- [l- (2,3-dihydroxypropyl) -5,6-methylenedioxy-lH-indol-3-yl] -3- (5,6-methylenedioxy-lH-indol ~ 3-yl) - maleimide;

( + )-2-[l-(2,3-Dihydroxypropyl)-5-jnethyl-lH-indol-3-yl]-3-(5-• methyl-lH-indol-3-yl)-maleinimid;(+) -2- [1- (2,3-dihydroxypropyl) -5-methyl-1H-indol-3-yl] -3- (5-methyl-1H-indol-3-yl) -maleimide;

(+)-2-[l-(2,3-Dihydroxypropyl)-5-nitro--lH-in.dol-3-yl]-3-(5-nitro-lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2,3-dihydroxypropyl) -5-nitro - lH-in.dol-3-yl] -3- (5-nitro-lH-indol-3-yl) maleimide ;

(+)-2-[1-(2,3-Dihydroxypropyl)-ö-methylthio-lH-indol-S-yl]-3-(5-methylthio-lH-indol-3-yl)-maleinimJö;(+) - 2- [1- (2,3-dihydroxypropyl) -o-methylthio-lH-indol-S-yl] -3- (5-methylthio-lH-indol-3-yl) -maleinimJö;

(+)-2-[1-(2,3-Dihydroxypropyl)-4,S-dimethoxy-lH-indol-S-yl]-3-(4,5-dimethoxy-lH-indol-3-yl)-maleinimid;(+) - 2- [1- (2,3-dihydroxypropyl) -4, S-dimethoxy-lH-indol-S-yl] -3- (4,5-dimethoxy-lH-indol-3-yl) - maleimide;

( + ) -2-[.1-(2,3-Dihydroxypropyl) -5,6-dimethoxy-lH-indol-3-i _t]-3-(5,6-dimethoxy-lH-indol-3-yl)-maleinimid;(+) - 2 - [. 1- (2,3-Dihydroxypropyl) -5,6-dimethoxy-1H-indol-3-i- _t ] -3- (5,6-dimethoxy-1H-indol-3-yl ) maleimide;

(-)-2-[5-Acetylanino-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(S-acetylamiiio-lH-indoi-S-yl) -maleinimid ;(-) - 2- [5-Acetylanino-1- (2,3-dihydroxypropyl) -1H-indol-3-yl] -3- (S-acetylamino-1H-indol-S-yl) -maleimide;

(-)-2-[5-Amino-l·· (2,3-dihydroxypropyi)-lH-indol-3-yl]-3-(5-alnino-lI.i-indol-3-yl)-maleinimid;(-) - 2- [5-Amino-l · * (2,3-dihydroxypropyl) -1H-indol-3-yl] -3- (5-alnino-1,1-i-indol-3-yl) -maleimide ;

(-)-2-[5-Benzyloxy-l-(2,3~dihydroxypropyl)-lH-indol-3-yl]-3-(5-benzyloxy-lH-indol-3-γΙ)-maleinimid;(-) - 2- [5-benzyloxy-l- (2,3 ~ dihydroxypropyl) -lH-indol-3-yl] -3- (5-benzyloxy-lH-indol-3-γΙ) maleimide;

(-)-2-[5-Brom-l-(2_/3-dihydroxypropyl)-lH-indol-3-yl]-3-(5-bromlH-indol-3-yl)-maleinimid.(-) - 2- [5-bromo-l- _{(2/3-dihydroxypropyl)} -lH-indol-3-yl] -3- (5-bromlH-indol-3-yl) maleimide.

(-)-2-[5-Chlor-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(5-chlor-lH-indol-3-yl)-maleinimid;(-) - 2- [5-chloro-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (5-chloro-lH-indol-3-yl) maleimide;

(-)-2-[5-Fluor-l- (2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(5-fluor-lH-indol-3-yl)-maleinimid;(-) - 2- [5-Fluoro-1- (2,3-dihydroxypropyl) -1H-indol-3-yl] -3- (5-fluoro-1H-indol-3-yl) -maleimide;

(-)-2-[5-Hydroxy-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]-3-(5-hydroxy-lH-indol-3-yl)-maleinimid;(-) - 2- [5-Hydroxy-l- (2,3-dihydroxypropyl) -lH-indol-3-yl] -3- (5-hydroxy-lH-indol-3-yl) maleimide;

(-)-2-[5-Trifluormethyl-l-(2,3-dihydroxypropyl)-lH-indol-3-yl]· 3-(5-trifluormethyl-lH-indol-3-yl)-maleinimid;(-) - 2- [5-Trifluoromethyl-1- (2,3-dihydroxypropyl) -1H-indol-3-yl] .3- (5-trifluoromethyl-1H-indol-3-yl) -maleimide;

(-)-2-[l-(2,3-Dihydroxypropyl)-5-methoxy-lH-indol-3-yl]-3-(5- methoxy-lH-indol-3-yl)-maleinimid;(-) - 2- [1- (2,3-Dihydroxypropyl) -5-methoxy-1H-indol-3-yl] -3- (5-methoxy-1H-indol-3-yl) -maleimide;

(-)-2-[1-(2,3-Dihydroxypropy1)-4,5-methylendioxy-lH-indol-3-yl ] -3- (4, S-methylendioxy-lH-indol-S-y.l) -maleinimid;(-) - 2- [1- (2,3-Dihydroxypropyl) -4,5-methylenedioxy-1H-indol-3-yl] -3- (4, S-methylenedioxy-1H-indole-Sy.l) - maleimide;

(-)-2-[l-(2,3-Dihydroxypropyl)-5,6-methylendioxy-lH-indol-3~ yl]-3-(5,6-methylendioxy-lH-indol-3-yl)-maleinimid;(-) - 2- [1- (2,3-Dihydroxypropyl) -5,6-methylenedioxy-1H-indol-3-yl] -3- (5,6-methylenedioxy-1H-indol-3-yl) - maleimide;

(-)-2-[l-(2,3-Dihydroxypropy:)-5-methyl-lH-indol-3-yl]-3-(5-methyl-lH-indol-3-yl)-maleinimid;(-) - 2- [l- (2,3-Dihydroxypropy:) - 5-methyl-lH-indol-3-yl] -3- (5-methyl-lH-indol-3-yl) maleimide;

(-)-2-[1-(2,3-Dihydroxypropy1)-5-nitro-lH-indol-3-yl]-3-(5-nitro-lH-indol-3-yl)-maleinimid;(-) - 2- [1- (2,3-Dihydroxypropy1) -5-nitro-lH-indol-3-yl] -3- (5-nitro-lH-indol-3-yl) maleimide;

(-)-2-[l-(2,3-Dihydroxypropyl)-5-methylthio-lH-indol-3-yl]-3-(5-methylthio-lH-indol -3-yl)-maleinimid;(-) - 2- [1- (2,3-Dihydroxypropyl) -5-methylthio-1H-indol-3-yl] -3- (5-methylthio-1H-indol-3-yl) -maleimide;

(-)-2-[l-(2,3-Dihydroxypropyl)-4,5-dimethoxy-lH-indol-3-yl]-3-(4,5-dimethoxy-iH-indol-3-yl)-maleinimid;(-) - 2- [l- (2,3-dihydroxypropyl) -4,5-dimethoxy-lH-indol-3-yl] -3- (4,5-dimethoxy-iH-indol-3-yl) - maleimide;

(-)-2-[l-(2,3-Dihydroxypropyl)-5,6-dimeohoxy-lH~indol-3-yl]-3-(5,6-dimethoxy-lH-indol-3-yl)-maleinimid;(-) - 2- [l- (2,3-dihydroxypropyl) -5,6-dimeohoxy-lH ~ indol-3-yl] -3- (5,6-dimethoxy-lH-indol-3-yl) - maleimide;

2-[5-Acetylamino-l-(3-hydroxypropyl)-lH-indol-3-yl]-3-(5-acetylamino-lII-indol-3-yl)-maleinimid;2- [5-Acetylamino-l- (3-hydroxypropyl) -lH-indol-3-yl] -3- (5-acetylamino-lII-indol-3-yl) maleimide;

2-[5-Amino-l-(3-hydroxypropyl)-lH-indol-3-yl]-3-(5-amino-lH-indol-3-yl)-maleinimid;2- [5-Amino-l- (3-hydroxypropyl) -lH-indol-3-yl] -3- (5-amino-lH-indol-3-yl) maleimide;

5 2-[5-Benzyloxy-l-(3-hydroxypropyl)-lH-indol-3-yl]-3-(5-benzyloxy-lH-indol-3-yl)-maleinimid;5 2- [5-Benzyloxy-1- (3-hydroxypropyl) -1H-indol-3-yl] -3- (5-benzyloxy-1H-indol-3-yl) -maleimide;

29997O -210- 29997O -210-

2- [5-Brom-l-(3-hydroxypropyl)-lH-indol-3-yl]-3-(5-brom-IH-indol-3-yl)-maleinimid;2- [5-bromo-1- (3-hydroxypropyl) -1H-indol-3-yl] -3- (5-bromo-1H-indol-3-yl) -maleimide;

2 - [ 5-Chlor-l-(3-hydroxypropyl)-lH-indol-3-yl]-3-(5-chlor-lH-indol-3-yl)-maleinimid;2 - [5-chloro-1- (3-hydroxypropyl) -1H-indol-3-yl] -3- (5-chloro-1H-indol-3-yl) -maleimide;

2-[5-Fluor-l-(3-hydroxypropyl)-lH-indol-3-yl]-3-(5-fluor-lH-• indol-3-yl)-maleinimid;2- [5-fluoro-1- (3-hydroxypropyl) -1H-indol-3-yl] -3- (5-fluoro-1H-indol-3-yl) -maleimide;

2-[5-Hydroxy-l-(3-hydroxypropyl)-lH-indol-3-yl]-3-(5-hydroxylH-indol-3-yl)-maleinimid;2- [5-hydroxy-l- (3-hydroxypropyl) -lH-indol-3-yl] -3- (5-hydroxylH-indol-3-yl) maleimide;

2-t5-Trifluormethyl-l-(3-hydroxypropyl)-5-trifluormethyl-lH-indol-3-yl]-3-(5-trifluormethyl-lH-indol-3-yl)-maleinimid;2-t5-trifluoromethyl-l- (3-hydroxypropyl) -5-trifluoromethyl-lH-indol-3-yl] -3- (5-trifluoromethyl-lH-indol-3-yl) maleimide;

2-[l-(3-Hydroxypropyl)-5-methoxy-*lH-indol-3-yl]-3-(5-methoxylH-indol-3-yl)-maleinimid;2- [l- (3-hydroxypropyl) -5-methoxy- * lH-indol-3-yl] -3- (5-methoxylH-indol-3-yl) maleimide;

2-[1-(3-Hydroxypropyl)-4,5-methylendioxy-lH-indol-3-yl]-3-(4, 3· methylendioxy-lH-indol-3-yl)-maleinimid;2- [1- (3-hydroxypropyl) -4,5-methylenedioxy-1H-indol-3-yl] -3- (4,3-methylenedioxy-1H-indol-3-yl) -maleimide;

2-[l-(3-Hydroxypropyl)--5,6-methylendioxy-lH-indol-3-yl]-3-(5_/6-n.ethylendioxy-lH-indol-3-yl)-maleinimid;2- [l- (3-hydroxypropyl) - 5,6-methylenedioxy-lH-indol-3-yl] -3- _{(5/6-n.ethylendioxy-lH-indol-3-yl)} maleimide;

2-[l-(3-Hydroxypropyl)-5-methyl-lH-indol-3-yl]-3-(5-methyl-lH-indol-3-yl)-maleinimid;2- [l- (3-hydroxypropyl) -5-methyl-lH-indol-3-yl] -3- (5-methyl-lH-indol-3-yl) maleimide;

2-[l-(3-Hydroxypropyl)-5-nitro-lH-indol-3-yl]-3-(5-nitro-lH-indol-3-yl)-maleinimid;2- [l- (3-hydroxypropyl) -5-nitro-lH-indol-3-yl] -3- (5-nitro-lH-indol-3-yl) maleimide;

2-[l-(3-Hydroxypropyl)-5-methylthio-lH-indol-3-yl]-3-(5-methylthio-lH-indol-3-yl)-maleinimid;2- [l- (3-hydroxypropyl) -5-methylthio-lH-indol-3-yl] -3- (5-methylthio-lH-indol-3-yl) maleimide;

2-[1-(S-Hydrox^^ropyl)-4,5-dimethoxy-lH-indol-3-yl]-3-(4,5-dimethoxy-IH-indol-3-yl)-maleinimid;2- [1- (S-Hydrox ^^ ropyl) -4,5-dimethoxy-lH-indol-3-yl] -3- (4,5-dimethoxy-IH-indol-3-yl) maleimide;

2- [ 1- (3-Hydroxypropyl) -5,6-dimethoxy-lH-in.-iol-3-yl] -3- (5,6-dimethoxy-IH-indol-3-yl)-maleinimid;2- [1- (3-hydroxypropyl) -5,6-dimethoxy-1H-in-iol-3-yl] -3- (5,6-dimethoxy-1H-indol-3-yl) -maleimide;

299970 -zn- , 299970 -zn-,

2-(S-Acetylamino-lH-indol-S-yl)-3-[5-acetylamino-l-(3 isothiocyanatopropyl) -lH-indol-3-y.l ] -raaleinimid;2- (S-acetylamino-1H-indol-S-yl) -3- [5-acetylamino-1- (3-isothiocyanatopropyl) -1H-indol-3-yl] -raaleinimide;

2-(5-Amino-lH-indol-3-yl)-3-[5-amino-l-(3-isothiocyanatopropyl)-lH-indol-3-yl]-maleinimid;2- (5-amino-lH-indol-3-yl) -3- [5-amino-l- (3-isothiocyanatopropyl) -lH-indol-3-yl] -maleimide;

2-(5-Benzyloxy-lH-indol-3~yl)-3-[5-benzyloxy-l-(3-isothiocyanatopropyl)~lH-indol-3-yl]-maleini^id;2- (5-benzyloxy-lH-indol-3 ~ yl) -3- [5-benzyloxy-l- (3-isothiocyanatopropyl) ~ lH-indol-3-yl] -maleini ^ id;

2-(5-Brom-lH-indol-3-yl)-3-[5-brom-l~(3-isothiocyanatopropyl)-lH-indol-3-yl]-maleinimid;2- (5-bromo-lH-indol-3-yl) -3- [5-bromo-l ~ (3-isothiocyanatopropyl) -lH-indol-3-yl] -maleimide;

2- (5-Chlor-lH-indo).--3-yl)-3-[5-chlor-l- (3-isothiocyanatopropyl)-lH-indol-3-yl]-maleinimid;2- (5-chloro-1H-indo) -3-yl) -3- [5-chloro-1- (3-isothiocyanatopropyl) -1H-indol-3-yl] -maleimide;

2-(5~Fluor-lH-indol-3-yl)-3-[5-fluor-l-(3-isothiocyanatopropyl)-lH-indol-3-yl]-iaaleinimid;2- (5 ~ fluoro-lH-indol-3-yl) -3- [5-fluoro-l- (3-isothiocyanatopropyl) -lH-indol-3-yl] -iaaleinimid;

2-(5-Hydroxy-lH-indol-3-yl)-3-[5-hydroxy-l-(3-isothiocyanatopropyl)-lH-indol-3-yl]-maleinimid;2- (5-hydroxy-lH-indol-3-yl) -3- [5-hydroxy-l- (3-isothiocyanatopropyl) -lH-indol-3-yl] -maleimide;

2-(5-Trifluormethyl-lH-indol-3-yl)-3-[5-trifluonnethyl-1-(3-isothiocyanatopropyl)-lH-indol-3"yl]-maleinimid;2- (5-trifluoromethyl-lH-indol-3-yl) -3- [5-trifluonnethyl-1- (3-isothiocyanatopropyl) -lH-indole-3 "yl] -maleimide;

2-[1-(3-Isothiocyanatopropyl)-5-methoxy-lH-indol-3-y1]-3-(5-methoxy-lH-indol-3-yl)-maleinimid;2- [1- (3-isothiocyanatopropyl) -5-methoxy-lH-indol-3-y1] -3- (5-methoxy-lH-indol-3-yl) maleimide;

2-[l-(3-Isothiocyanatopropyl)-4,5-methylendioxy-lH-indol-3-"i]· 0 3-(4,5-methylendioxy-lH-indol-3-y1)-maleinimid;2- [1- (3-isothiocyanatopropyl) -4,5-methylenedioxy-1H-indole-3- "i] x 3- (4,5-methylenedioxy-1H-indol-3-yl) -maleimide;

2-tl-(3--Isothiocyanatopropyl)-5,6-methylendioxy-lH-indol-3-yl] 3-(5,6-methylendio5cy-lH-indol-3-yl)-maleinimid;2-tl- (3-isothiocyanatopropyl) -5,6-methylenedioxy-1H-indol-3-yl] -3- (5,6-methylenedio5-cy1-lH-indol-3-yl) -maleimide;

2-[1-(3-Isothiocyanatopropyl)-5-methyl-lH-indol-3-yl]-3-(5-methyl-lH-indol-3-yl)-maleinimid; 2- [ 1- (3-isothiocyanatopropyl) -5-methyl-1H-indol-3-yl] -3- (5-methyl-1H-indol-3-yl) -maleimide;

2-[1-(3-Isothiocyanatopropyl)-5-nitro-lH-indol-3-yl]-3-(5-nitro-lH-indol-3-yl)-maleinimid;2- [1- (3-isothiocyanatopropyl) -5-nitro-lH-indol-3-yl] -3- (5-nitro-lH-indol-3-yl) maleimide;

2-[l-(3-Isothiocyanatopropyl)-5-methylthio-lH-indol-3-yl]-3-(5 methylthio-lH-indol-3-yl) -maleinimid;2- [1- (3-isothiocyanatopropyl) -5-methylthio-1H-indol-3-yl] -3- (5-methylthio-1H-indol-3-yl) -maleimide;

2-[1-(3-Isothiocyanatopropyl)-4,5-dimethoxy-lH-indol-3-yl]-3-(4,5-dimethoxy-lH-indol-3-yl)-maleinimid;2- [1- (3-isothiocyanatopropyl) -4,5-dimethoxy-lH-indol-3-yl] -3- (4,5-dimethoxy-lH-indol-3-yl) maleimide;

2-[1-(3-Isothiocyanatopropyl)-5,6-dimethoxy-lH-indol-3-yl]-3-(5,6-dimethoxy-lH-indol-3-yl)-maleinimid;2- [1- (3-isothiocyanatopropyl) -5,6-dimethoxy-lH-indol-3-yl] -3- (5,6-dimethoxy-lH-indol-3-yl) maleimide;

(±)-2-(5-Acetylamino-lH-indol-3-yl)-3-[5-acetylamino-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;(±) -2- (5-acetylamino-lH-indol-3-yl) -3- [5-acetylamino-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide;

(±)-2-(5-Amino-lH-indol-3-yl)-3-[5-amino-l-(2-methoxy-3-dimethylaminopropyl)-lH~iiidol-3-yl] -maleinimid;(±) -2- (5-amino-1H-indol-3-yl) -3- [5-amino-1- (2-methoxy-3-dimethylaminopropyl) -1H-2-imidol-3-yl] -maleimide;

(±)-2-(5-Benzyloxy-lH-indol-3-yl)-3-[5-benzyloxy-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;(±) -2- (5-benzyloxy-lH-indol-3-yl) -3- [5-benzyloxy-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide;

(±)-2-(5-Brom-lH-indol-3-yl)-3-[5-brom-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;(±) -2- (5-bromo-lH-indol-3-yl) -3- [5-bromo-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide;

(±)-2-(5-Chlor-lH-indol-3-yl)-3-[5-chlor-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;(±) -2- (5-chloro-lH-indol-3-yl) -3- [5-chloro-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide;

(±)-2-(5-Fluor-lH-indol-3-yl)-3-[5-fluor-i-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;(±) -2- (5-fluoro-lH-indol-3-yl) -3- [5-fluoro-i- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide;

(±)-2-(5-Hydroxy-lH-indol-3-yl)-3-[5-hydroxy-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;(±) -2- (5-hydroxy-lH-indol-3-yl) -3- [5-hydroxy-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide;

(±)-2-(5-Trifluo-methyl-lH-indol-3-yl)-3-[5-trifluormethyl-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;(±) -2- (5-methyl-lH-Trifluo-indol-3-yl) -3- [5-trifluoromethyl-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] - maleimide;

(±)-2-(5-Methoxy-lH-indol-3-yl)-3-[5-methoxy-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;(±) -2- (5-methoxy-lH-indol-3-yl) -3- [5-methoxy-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide;

5 (±)-2-[1-(2-Methoxy-3-dimethylaminopropyl)-4,5-methylendioxylH-indol-3-yl]-3-(4,S-methylendioxy-lH-indol-S-yl)-maleinimid;5 (±) -2- [1- (2-Methoxy-3-dimethylaminopropyl) -4,5-methylenedioxyH-indol-3-yl] -3- (4, S -methylenedioxy-1H-indol-5-yl) maleimide;

-213--213-

(±) -2-[l-(2-Methoxy-3-dimethylaminopropylj -5, 6-methylendioxylH-indol •3-yl]-3-(5_/6-methylendioxy-lH-indol-3-yl)-male.inimid;(±) -2- [1- (2-Methoxy-3-dimethylaminopropyl-5,6-methylenedioxyH-indole-3-yl] -3- (5 _/ 6-methylenedioxy-1H-indol-3-yl) -male .inimid;

(±) -2«[l-(2-Methoxy-3-dimethylaminopropy1)-S-methyl-lH-indol-S yll-?-(5-methyl-lH-indol-3-yl)-maleiniiaid;(±) -2- [[1- (2-methoxy-3-dimethylaminopropyl) -S-methyl-1H-indole-3-yl-? - (5-methyl-1H-indol-3-yl) -maleiniaide;

(±)-2-[l-(2-Methoxy-3-dimethylaminopropyl)-5-nitro-lH-indol-3-yl]-3-(5-nitro-lH-indol-3-yl)-maleinimid;(±) -2- [l- (2-methoxy-3-dimethylaminopropyl) -5-nitro-lH-indol-3-yl] -3- (5-nitro-lH-indol-3-yl) maleimide;

(±)-2-[1-(2-Methoxy-3-dimethylaminopropyl)-5-methylthio-lH-indol-3-yl]-3-(5-methylthio-lH-indol-3-yl)-maleinimid;(±) -2- [1- (2-methoxy-3-dimethylaminopropyl) -5-methylthio-lH-indol-3-yl] -3- (5-methylthio-lH-indol-3-yl) maleimide;

(±)-2-(4,S-Dimethoxy-lH-indol-S-yl)-3-[4,5-dimethoxy-l-(2-methoxy-3-dimethylaminopropyl)-lH-indul-3-yl]-maleinimid;(±) -2- (4, S-dimethoxy-lH-indol-S-yl) -3- [4,5-dimethoxy-l- (2-methoxy-3-dimethylaminopropyl) -lH-indul-3-yl ] maleimide;

(±)-2-(5,6-Dimethoxy-lH-Indol-3-yl)-3-[5,6-dimethoxy-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;(±) -2- (5,6-dimethoxy-lH-indol-3-yl) -3- [5,6-dimethoxy-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl ] maleimide;

-2-(5-Acetylamino-lH-indol-3-yi; -3-[5-ac€!tylamino-l- (2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;-2- (5-acetylamino-1H-indol-3-yl; -3- [5-acylthio-1- (2-methoxy-3-dimethylaminopropyl)-1H-indol-3-yl] -maleimide;

(+)-2-(5-Amino-lH-indol-3-yl)-3-[5-amino-l~(2-methoxy-3-dimethylaminopropy 1) -lH-indol-3-yl]-maleinim.id;(+) - 2- (5-amino-1H-indol-3-yl) -3- [5-amino-1 - (2-methoxy-3-dimethylaminopropyl) -1H-indol-3-yl] -maleim .id;

(+)-2-(5-Benzyloxy-lH-indol-3-yl)-3-[5-benzyloxy-l-(2-methoxy 3-dimethylaminopropy1)-lH-indol-3-y1]-maleinimid;(+) - 2- (5-Benzyloxy-1H-indol-3-yl) -3- [5-benzyloxy-1- (2-methoxy-3-dimethylaminopropyl) -1H-indol-3-yl] -maleimide;

(+)-2-(5-Brom-lH-indol-3-yl)-3-[5-brom-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;(+) - 2- (5-bromo-lH-indol-3-yl) -3- [5-bromo-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide;

(+)-2-(5-Chlor-lH-indol-3-yl)-3-[5-chlor-i-(2-methoxy-3-dime.thylaminopropy 1) -lH-indol-3-yl] -maleinimid;(+) - 2- (5-Chloro-1H-indol-3-yl) -3- [5-chloro-1- (2-methoxy-3-dime-thyl-aminopropyl-1) -H-indol-3-yl] maleimide;

(+)-2-(5-Fluor-lH-indol-3-yl)-3-[5-fluor-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;(+) - 2- (5-fluoro-lH-indol-3-yl) -3- [5-fluoro-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide;

(+)-2-(5-Hydroxy-lH-indol-3-yl)-3-[5-hydroxy-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;(+) - 2- (5-hydroxy-lH-indol-3-yl) -3- [5-hydroxy-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide;

(+)-2-(5-Trifluormethyl-lH-indol-3-yl)-3-[5-trifluormethyl-i-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-naleinimid;(+) - 2- (5-trifluoromethyl-lH-indol-3-yl) -3- [5-trifluoromethyl-i- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -naleinimid;

(+)-2-(5-Methoxy-lH-indol-3-yl)-3-[5-methoxy-l-(2-methoxy-3-dimethy? aminopropyl)-lH-indol-3-yl]-maleinimid;(+) - 2- (5-Methoxy-1H-indol-3-yl) -3- [5-methoxy-1- (2-methoxy-3-dimethyl-aminopropyl) -H-indol-3-yl] - maleimide;

(+)-2-[1-(2-Methoxy-3-dimethylaminopropyl)-4,5-methylendioxylH-indol-3-yl]-3-(4,5-methylendioxy-lH-irdo:.-3-yl)-maleinimid;(+) - 2- [1- (2-methoxy-3-dimethylaminopropyl) -4,5-methylendioxylH-indol-3-yl] -3- (4,5-methylendioxylH-IRDO: .- 3-yl ) maleimide;

(+)-2-[l-(2-Methoxy-3-dimethylaminopropyl)-5,6-methylendicxylH-indol-3-yl]-3-(5,6-methylendioxy-lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-methoxy-3-dimethylaminopropyl) -5,6-methylendicxylH-indol-3-yl] -3- (5,6-methylenedioxy-lH-indol-3-yl) - maleimide;

(+)-2-[l-(2-Methoxy-3-dimethylaminopropyl)-5-methyl-lH-indol-3-yl]-3-(5-methyl-lH-indol-3-yl)-mal'3inimid;(+) - 2- [l- (2-methoxy-3-dimethylaminopropyl) -5-methyl-lH-indol-3-yl] -3- (5-methyl-lH-indol-3-yl) times' 3inimid;

(+)-2-[l-(2-Methoxy-3-dimethylaminopropyl)-5-nitro-IH-indol-3-yl]-3-(5-nitro-lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-methoxy-3-dimethylaminopropyl) -5-nitro-IH-indol-3-yl] -3- (5-nitro-lH-indol-3-yl) maleimide;

(+)-2-[l-(2-Methoxy-3-dimethylaminopropyl)-5-met.hylthiT-lH-indol-3-yl]-3-(5-methylthio-lH-indol-3-yl)-maleinimid;(+) - 2- [l- (2-methoxy-3-dimethylaminopropyl) -5-met.hylthiT-lH-indol-3-yl] -3- (5-methylthio-lH-indol-3-yl) - maleimide;

(+)-2-(4_/5-Dimethoxy-lH-indol-3-yl)-3-[4,5-dimethoxy-l-(2-raethoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;(+) - 2- (4 _/ 5-Dimethoxy-1H-indol-3-yl) -3- [4,5-dimethoxy-1- (2-raethoxy-3-dimethylaminopropyl) -lH-indol-3-yl ] maleimide;

(+)-2-(5,6-Dimethoxy-lH-Indol-3-yl)-3-[5,6-dimethoxy-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;(+) -2- (5,6-dimethoxy-lH-indol-3-yl) -3- [5,6-dimethoxy-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl ] maleimide;

(-)-2-(5-Acetylamino-lH-indol-3-yl)-3-[5-acetylamino-l-(2-0 methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;(-) - 2- (5-Acetylamino-1H-indol-3-yl) -3- [5-acetylamino-1- (2-O-methoxy-3-dimethylaminopropyl) -1H-indol-3-yl] -maleimide ;

(-)-2-(5-Amino-lH-indol-3-yl)-3-[5-amino-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;(-) - 2- (5-amino-lH-indol-3-yl) -3- [5-amino-l- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide;

(-) -2-(5-Benzyloxy-lH-indol-3-yl)-3-[5-benzyloxy-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;(-) -2- (5-Benzyloxy-1H-indol-3-yl) -3- [5-benzyloxy-1- (2-methoxy-3-dimethylaminopropyl) -1H-indol-3-yl] -maleimide;

(-) -2-(5-Brom-lH-indol-3-yl)-3-[5-brcm-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;(-) -2- (5-Bromo-1H-indol-3-yl) -3- [5-bromo-1- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide;

-2 3 5--2 3 5-

(_)_2-(5-Chlor-lH-indol-3-yl)-3-[5-ChIOr-I-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;(_) _ 2- (5-chloro-lH-indol-3-yl) -3- [5-chloro-I- (2-methoxy-3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide;

(-)-2-(5-Fluor-lH-indol-3-yl)-3-[5-fluor-l-(2-methoxy-3-dimethylaminopropy 1) -lH-indol-3-yl]-maleir.imid;(-) - 2- (5-Fluoro-1H-indol-3-yl) -3- [5-fluoro-1- (2-methoxy-3-dimethylaminopropyl) -1H-indol-3-yl] -malea .imid;

(-)-2-(5-Hydroxy-lH-indol-3-yl)-3-[5-hydroxy-l-(2-methoxy-3- dimethy laminopropy 1)-IH-indol-3-yl]-maleinimid;(-) - 2- (5-Hydroxy-1H-indol-3-yl) -3- [5-hydroxy-1- (2-methoxy-3-dimethylpropyl-1-yl) -IH-indol-3-yl] - maleimide;

(-)-2-(5-Trifluormethyl-lH-indol-3-yl)-3-[5-trifluormethyl-l-(2-methoxy-3-dimethylaminopropyl)'lH-indol~3-yl]-maleinimid;(-) - 2- (5-trifluoromethyl-lH-indol-3-yl) -3- [5-trifluoromethyl-l- (2-methoxy-3-dimethylaminopropyl) 'lH-indol ~ 3-yl] -maleimide;

(-)-2-(5-Methoxy-lH-indol-3-yl)-3-[5-methoxy-l-(2-methoxy-3-dimethylaminopropy1)-lH-indol-3-yl]-maleinimid;(-) - 2- (5-methoxy-lH-indol-3-yl) -3- [5-methoxy-l- (2-methoxy-3-dimethylaminopropy1) -lH-indol-3-yl] -maleimide;

(-) -2-[l-(2-Methoxy-3-dimethylaminopropyl)-4,5-methylendioxylH-indol-3-yl]-3-(4,5-methylendioxy-lH-indol-3-yl)-maleinimid;(-) -2- [1- (2-Methoxy-3-dimethylaminopropyl) -4,5-methylenedioxyH-indol-3-yl] -3- (4,5-methylenedioxy-1H-indol-3-yl) - maleimide;

(-)-2-[l-(2-Methoxy-3-dimethylaminopropyl)-5,6-methylendioxylH-indol-3-yl]-3-(5,6-methylendioxy-lH-indol-3-yl)-rualeiniiüid;(-) - 2- [l- (2-methoxy-3-dimethylaminopropyl) -5,6-methylendioxylH-indol-3-yl] -3- (5,6-methylendioxylH-indol-3-yl) - rualeiniiüid;

(-)-2-[l-(2-Methoxy-3-dimethylaminopropyl)-S-methyl-lH-indol-nyl]-3-(5-methyl-lH-indol-3-yl)-maleinimid;(-) - 2- [(2-methoxy-3-dimethylaminopropyl) l- -S-methyl-lH-indol-nyl] maleimide -3- (5-methyl-lH-indol-3-yl);

(-)-2-[l-(2-Methoxy-3-dimethylaminopropyl)-S-nitro-lH-indol-S-yl]-3-(5-nitro-lH-indol-3-yl)-maleinimid;(-) - 2- [(2-methoxy-3-dimethylaminopropyl) l- -S-nitro-lH-indol-S-yl] -maleimide -3- (5-nitro-lH-indol-3-yl);

(-)-2-[l-(2-Methoxy-3-dimethylaminopropyl)-5-methylthio-lH-indol-3-yl]-3-(5-methylthio-lH-indol-3-yl)-maleinimid;(-) - 2- [(2-methoxy-3-dimethylaminopropyl) l- -5-methylthio-lH-indol-3-yl] -maleimide -3- (5-methylthio-lH-indol-3-yl);

(-)-2-(4,5-Dimethcxy-lH-indoI-3-yl)-3-[4,5-dimethoxy-l-(2-raethoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;(-) - 2- (4,5-Dimethcxy-lH-indol-3-yl) -3- [4,5-dimethoxy-l- (2-raethoxy-3-dimethylaminopropyl) -lH-indol-3-yl ] maleimide;

(-)-2-(5_/6-Dimethoxy-lH-Indol-3-yl)-3-[5,6-dimethoxy-l-(2-methoxy-3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;(-) - 2- (5 _/ 6-Dimethoxy-1H-indol-3-yl) -3- [5,6-dimethoxy-1- (2-methoxy-3-dimethylaminopropyl)-1H-indol-3-yl ] maleimide;

2-(5-Acetylamino-lH-indol-3-yl)-3-[5-acetylamino-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-maleinimid;2- (5-acetylamino-lH-indol-3-yl) -3- [5-acetylamino-l- (2-dimethylaminoethyl) -lH-indol-3-yl] -maleimide;

-²¹⁶"- ²¹⁶ "

2-(5-Amino-lH-indol-3-yl)-3-[5-amino-l-(2-dimethylaminoethy1) lH-indol-3-yl]-maleinimid;2- (5-amino-1H-indol-3-yl) -3- [5-amino-1- (2-dimethylaminoethyl) -1H-indol-3-yl] -maleimide;

2-(5-Benzyloxy-lH-indol-3-yl)-3-[5-benzyloxy-l-(2-dimethylaminoethy1)-lH-indol-3-yi]-maleinimid;2- (5-benzyloxy-lH-indol-3-yl) -3- [5-benzyloxy-l- (2-dimethylaminoethy1) -lH-indol-3-yl] -maleimide;

2-(5-Brom-lH-indol-3-yl)-3-[5-brom-l-(2-dimethylaminoethyl)-IH-indol-3-yl]-maleinimid;2- (5-bromo-lH-indol-3-yl) -3- [5-bromo-l- (2-dimethylaminoethyl) -IH-indol-3-yl] -maleimide;

2-(5-Chlor-lH-indol-3-yl)-3-[5-chlor-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-maleinimid;2- (5-chloro-lH-indol-3-yl) -3- [5-chloro-l- (2-dimethylaminoethyl) -lH-indol-3-yl] -maleimide;

2-(5-Fluor-lH-indol-3-yl)-3-[5-fluor-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-maleinimid;2- (5-fluoro-lH-indol-3-yl) -3- [5-fluoro-l- (2-dimethylaminoethyl) -lH-indol-3-yl] -maleimide;

2-(5-Hydroxy-lH-indol-3-yl)-3-[5-hydroxy-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-maleinimid;2- (5-hydroxy-lH-indol-3-yl) -3- [5-hydroxy-l- (2-dimethylaminoethyl) -lH-indol-3-yl] -maleimide;

2-(5-Trifluormethyl-lH-indol-3-yl)-3-[5-trifluormethyl-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-maleinimid;2- (5-trifluoromethyl-lH-indol-3-yl) -3- [5-trifluoromethyl-l- (2-dimethylaminoethyl) -lH-indol-3-yl] -maleimide;

2-(5-Metho):y-lH-indol-3-yl)-3-[5-methoxy-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-maleinimid;2- (5-Metho): y-lH-indol-3-yl) -3- [5-methoxy-l- (2-dimethylaminoethyl) -lH-indol-3-yl] -maleimide;

2-[1-(2-Dimethylaminoethyl)-4,5-methylendioxy-lH-indol-3-yl]-3-(4,S-methylendioxy-lH-indol-S-yl)-maleinimid;2- [1- (2-dimethylaminoethyl) -4,5-methylenedioxy-lH-indol-3-yl] -3- (4, S-methylenedioxy-lH-indol-S-yl) maleimide;

2-[l-(2-Dimethylaminoethyl)-5,6-methylendioxy-lH-indol-3-yl]-3-(5,6-methylendioxy-lH-indol-3-yl)-maleinimid;2- [l- (2-dimethylaminoethyl) -5,6-methylenedioxy-lH-indol-3-yl] -3- (5,6-methylenedioxy-lH-indol-3-yl) maleimide;

2-(5-Methyl-lH-indol-3-yl)-3-[5-methyl-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-maleinimid;2- (5-methyl-lH-indol-3-yl) -3- [5-methyl-l- (2-dimethylaminoethyl) -lH-indol-3-yl] -maleimide;

2-[l-(2-Dimethylaminoethyl)-5-nitro-lH-indol-3-yl]-3-(5-nitrolH-indol-3-yl)-maleinimid;2- [l- (2-dimethylaminoethyl) -5-nitrolH-indol-3-yl] -3- (5-nitrolH-indol-3-yl) maleimide;

2-[l-(2-Dimethylaminoethyl)-5-methylthio-lH-indol-3-yl]-3-(5-methylthio-lH-indol-3-yl)-maleinimid;2- [l- (2-dimethylaminoethyl) -5-methylthio-lH-indol-3-yl] -3- (5-methylthio-lH-indol-3-yl) maleimide;

2-(4,5-Dimethoxy-lH-indol-3-yl)-3-[4,5-dimethoxy-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-maleinimid;2- (4,5-dimethoxy-lH-indol-3-yl) -3- [4,5-dimethoxy-l- (2-dimethylaminoethyl) -lH-indol-3-yl] -maleimide;

2-(5_;6-Dimethoxy-lH-indol-3-yl)-3-[5,6-dimethoxy-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-maleinimid;2- _(5, 6-Dimethoxy-lH-indol-3-yl) -3- [5,6-dimethoxy-l- (2-dimethylaminoethyl) -lH-indol-3-yl] -maleimide;

2-(5-Acetylamino-lH-indol-3-yl)-3-[5-acetylamino-l--(3-dimethylaminopropyl)-lH-indol~3-yl]-maleinimid;2- (5-acetylamino-lH-indol-3-yl) -3- [5-acetylamino-l - (3-dimethylaminopropyl) -lH-indol ~ 3-yl] -maleimide;

2-(5-Amino-lH-indol-3-yl)-3-[5-amino-l-(3-dimethylaminopropyl) lH-indol-3-yl]-maleinimid;2- (5-amino-1H-indol-3-yl) -3- [5-amino-1- (3-dimethylaminopropyl) -1H-indol-3-yl] -maleimide;

2-(5-Benzyloxy-lH-indol-3-yl)-3-[5-benzyloxy-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;2- (5-benzyloxy-lH-indol-3-yl) -3- [5-benzyloxy-l- (3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide;

2-(5-Brom-lH-indol-3-yl)-3-[5-brom-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;2- (5-bromo-lH-indol-3-yl) -3- [5-bromo-l- (3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide;

2-(5-Chlor-lH-indol-3-yl)-3-[5-chlor-l-(3-dimethylaminopropyl) lH-indol-3-yl]-maleinimid;2- (5-chloro-1H-indol-3-yl) -3- [5-chloro-1- (3-dimethylaminopropyl) -1H-indol-3-yl] -maleimide;

2-(5-Fluor-lH-indol-3-yl)-3-[5-fluor-l-(3-dimethylaminopropyl) lH-indol-3-yl]-maleinimid;2- (5-fluoro-1H-indol-3-yl) -3- [5-fluoro-1- (3-dimethylaminopropyl) -1H-indol-3-yl] -maleimide;

2-(5-Hydroxy-lH-indol-3-yl)-3-[5-hydroxy-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;2- (5-hydroxy-lH-indol-3-yl) -3- [5-hydroxy-l- (3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide;

2-(5-Trifluormethyl-lH-indol-3-yl)-3-[5-trifluormethyl-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;2- (5-trifluoromethyl-lH-indol-3-yl) -3- [5-trifluoromethyl-l- (3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide;

2-(5-Methoxy-lH-indol-3-yl)-3-[5-methoxy-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;2- (5-methoxy-lH-indol-3-yl) -3- [5-methoxy-l- (3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide;

2-[l-(3-Dimethylaminopropyl)-4,5-methylendioxy-lH-indol-3-yl]-3-(4,5-methylendioxy-lH-indol-3-yl)-maleinimid;2- [l- (3-dimethylaminopropyl) -4,5-methylenedioxy-lH-indol-3-yl] -3- (4,5-methylenedioxy-lH-indol-3-yl) maleimide;

2-[l-(3-Dimethylaminopropyl)-5,6-methylendioxy-lH-indol-3-yl]-3-(5,6-methylendioxy-lH-indol-3-yl)-maleinimid; 2- [1- (3-dimethylaminopropyl) -5,6-methylenedioxy-1H-indol-3-yl] -3- (5,6-methylenedioxy-1H-indol-3-yl) -maleimide;

-218--218-

2-(5-Methyl-lH-indol-3-yl)-3-[5-methyl-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;2- (5-methyl-lH-indol-3-yl) -3- [5-methyl-l- (3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide;

2-[l-(3-Dimethylaminopropyl)-5-nitro-lH-indol-3-yl]-3-(5-nitrolH-indol-3~yl)-maleinimid;2- [l- (3-dimethylaminopropyl) -5-nitrolH-indol-3-yl] -3- (5-nitrolH-indol-3 ~ yl) maleimide;

2-[l-(3-Dimethylaminopropyl)-5-methylthio-lH--indol-3-yl]-3-(5-' methylthio-lH-indol-3-yl)-maleinimid;2- [1- (3-dimethylaminopropyl) -5-methylthio-1H-indol-3-yl] -3- (5'-methylthio-1H-indol-3-yl) -maleimide;

2~ (4,5-Dimethoxy~lH-indol-3-yl)-3-[4,5-dimethoxy-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-maleiniraid;2 - (4,5-dimethoxy-1H-indol-3-yl) -3- [4,5-dimethoxy-1- (3-dimethylaminopropyl) -1H-indol-3-yl] -maleiniride;

2-(5,6-Dimethoxy-lH-indol-3-yl) -3-[5, 6-di?nethoxy-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;2- (5,6-dimethoxy-1H-indol-3-yl) -3- [5,6-diethoxy-1- (3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide;

2-(5-Acetylamino-lH-indol-3-yl)-3-[5-acetylamino-l-(3-methylaminopropyl)-lH-indol-3-yl]-maleinimid;2- (5-acetylamino-lH-indol-3-yl) -3- [5-acetylamino-l- (3-methylaminopropyl) -lH-indol-3-yl] -maleimide;

2-(5-Amino-lH-indol-3-yl)-3-[5-amino-l-(3-methylaminopropyl)-lH-indol-3-yl]-maleinimid;2- (5-amino-lH-indol-3-yl) -3- [5-amino-l- (3-methylaminopropyl) -lH-indol-3-yl] -maleimide;

2-(5-Benzyloxy-lH-indol-3-yl)-3-[5-benzyloxy-l-(3-methylaminopropyl)-lH-indol-3-yl]-maleinimid;2- (5-benzyloxy-lH-indol-3-yl) -3- [5-benzyloxy-l- (3-methylaminopropyl) -lH-indol-3-yl] -maleimide;

2-(5-Brom-lH-indol-3-yl)-3-[5-brom-l-(3-methylaminopropyl)-IH-indol-3-yl]-maleinimid;2- (5-bromo-lH-indol-3-yl) -3- [5-bromo-l- (3-methylaminopropyl) -IH-indol-3-yl] -maleimide;

2-(5-Chlor-lH-indol-3-yl)-3-[5-chlor-l-(3-methylaminopropyl)-lH-indol-3-yl]-maleinimid;2- (5-chloro-lH-indol-3-yl) -3- [5-chloro-l- (3-methylaminopropyl) -lH-indol-3-yl] -maleimide;

2-(5-Fluor-lH-indol-3-yl)-3-[5-fluor-l-(3-methylaminopropyl)-lH-indol-3-yl]-maleinimid;2- (5-fluoro-lH-indol-3-yl) -3- [5-fluoro-l- (3-methylaminopropyl) -lH-indol-3-yl] -maleimide;

2-(5-Hydroxy-lH-indol-3-yl)-3-[5-hydroxy-l-(3-raethylaminopropyl)-lH-indol-3-yl]-maleinimid;2- (5-hydroxy-lH-indol-3-yl) -3- [5-hydroxy-l- (3-raethylaminopropyl) -lH-indol-3-yl] -maleimide;

2-(5-Trifluormethyl-lH-indol-3-yl)-3-[5-trifluormethyl-l-(3-methylaminopropyl)-lH-indol-3-yl]--maleinimid;2- (5-trifluoromethyl-lH-indol-3-yl) -3- [5-trifluoromethyl-l- (3-methylaminopropyl) -lH-indol-3-yl] - maleimide;

-219--219-

2-(5-Methoxy-lH-indol-3-yl)-3-[5-methoxy-l-(3-methylaminopropyl)-lH-indol-3-yl]-maleinimid;2- (5-methoxy-lH-indol-3-yl) -3- [5-methoxy-l- (3-methylaminopropyl) -lH-indol-3-yl] -maleimide;

2-[l-(3-Methylaminopropyl)-4_;5-methylendioxy-lH-indol-3-yl]-3-(4,5-methylendioxy-lH-indol-3-yl)-maleinimid;2- [1- (3-methylaminopropyl) -4 _; 5-methylenedioxy-lH-indol-3-yl] -3- (4,5-methylenedioxy-lH-indol-3-yl) maleimide;

2-[l-(3-Methylaminopropyl)-5,6-methylendioxy-lH-indol-3-yl]-3-. (5,ö-methylendioxy-lH-indol-S-yl)-maleinimid;2- [l- (3-methylaminopropyl) -5,6-methylenedioxy-lH-indol-3-yl] -3-. (5, ö-methylenedioxy-lH-indol-S-yl) maleimide;

2-(5-Methyl-lH-indol-3-yl)-3=[5-methyl-l-(3-methylaminopropyl) lH-i ndol-:}-yl ] -maleinimid;2- (5-methyl-1H-indol-3-yl) -3 = [5-methyl-1- (3-methylaminopropyl) -1H-indol-1-yl] -maleimide;

2-[1-(3-Methylaminopropyl)-5-nitro-lH-indol-3-yl]-3-(5-nitrolH-indol-3-yl)-maleinimid;2- [1- (3-methylaminopropyl) -5-nitrolH-indol-3-yl] -3- (5-nitrolH-indol-3-yl) maleimide;

2-[l-(3-Methylaminopropyl)-5-methylthio-lH-indol-3-yl]-3-(5-methylthio-lH-indol-3-yl)-maleinimid;2- [l- (3-methylaminopropyl) -5-methylthio-lH-indol-3-yl] -3- (5-methylthio-lH-indol-3-yl) maleimide;

2-(4,5-Dimethoxy-lH-indol-3-yl)-3-[5,6-dimethoxy-l-(3-methylaminopropyl)-lH-indol-3-yl]-maleinimid;2- (4,5-dimethoxy-lH-indol-3-yl) -3- [5,6-dimethoxy-l- (3-methylaminopropyl) -lH-indol-3-yl] -maleimide;

2-(5,6-Dimethoxy-lH-indol-3-yl)-3-[5,6-dimethoxy-l-(3 methylaminopropyl)-lH-indol-3-yl]-maleinimid;2- (5,6-dimethoxy-1H-indol-3-yl) -3- [5,6-dimethoxy-1- (3-methylaminopropyl) -1H-indol-3-yl] -maleimide;

2-(5-Acetylamino-lH-indol-3-yl)-3-[5-acetylainino-l--(3-(4-morpholino)propyl)-IH-indol-3-yl]-maleinimid;2- (5-acetylamino-lH-indol-3-yl) -3- [5-acetylainino-l - (3- (4-morpholino) propyl) -IH-indol-3-yl] -maleimide;

2-(5-Amino-lH-indol-3-yl)-3-[5-amino-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-maleinimid;2- (5-amino-lH-indol-3-yl) -3- [5-amino-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -maleimide;

2-(5-Benzyloxy-lH-indol-3-yl)-3-[5-benzyloxy-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-maleinimid;2- (5-benzyloxy-lH-indol-3-yl) -3- [5-benzyloxy-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -maleimide;

2-(5-Brom-lH-indol-3-yl)-3-[5-brom-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-maleinimid;2- (5-bromo-lH-indol-3-yl) -3- [5-bromo-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -maleimide;

2-(5-Chlor-lH-indol-3-yl)-3-[5-chlor-l-(3-(4-morpholino)propyl)-IH-indol-3-yl]-maleinimid;2- (5-chloro-lH-indol-3-yl) -3- [5-chloro-l- (3- (4-morpholino) propyl) -IH-indol-3-yl] -maleimide;

? -220- ? -220-

2-(5-Fluor-lH-indol-3»yl)-3-[5-fluor-l-(3-'(4-raorpholino)propyl)-lH"indol-3-yl]-maleinimid;2- (5-fluoro-lH-indole-3 'yl) -3- [5-fluoro-l- (3' - (4-raorpholino) propyl) -lH "indol-3-yl] -maleimide;

2-(5-Hydroxy-lH-indol-3-yl)-3-[5-hydroxy-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-maleinimid;2- (5-hydroxy-lH-indol-3-yl) -3- [5-hydroxy-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -maleimide;

2-(5-Trifluormethyl-lH-indol-3-yl)-3~[5-trifluorraethyl-l-(3-(4-• morpholino)propyl)-lH-inaol-3-yl]-maleinimid;2- (5-trifluoromethyl-1H-indol-3-yl) -3- [5-trifluoro-ethyl-1- (3- (4-morpholino) -propyl) -1H-inaol-3-yl] -maleimide;

2-(4,5-Methylendioxy-lH-indol-3-yl)-3-[4₍5-methylendioxy-l-(3-(4-morpholino) propyl) -lH-inclol-3-yl]--n!aleinimid;2- (4,5-methylenedioxy-1H-indol-3-yl) -3- [4 ₍ 5-methylenedioxy-1- (3- (4-morpholino) propyl) -1H-inclol-3-yl] - n aleinimid!;

2-(5,6-Methylendioxy-lH-indol-3-yl)-3-[5,6-methylendioxy-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-maleinimid;2- (5,6-methylenedioxy-lH-indol-3-yl) -3- [5,6-methylenedioxy-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -maleimide ;

2-{5-Methyl-lH-indol-3-yl)-3-[5-methyl-l-(3-(4-morpholino)propyl)-lH-indol~3-yl]-maleinimid;2- {5-methyl-lH-indol-3-yl) -3- [5-methyl-l- (3- (4-morpholino) propyl) -lH-indol ~ 3-yl] -maleimide;

2-[l-(3-(4-Morpholino)propyl)-5-nitro-lH-indol-3-yl]-3-(5-nitro-lH-indol-3-yl)-maleinimid;2- [l- (3- (4-morpholino) propyl) -5-nitro-lH-indol-3-yl] -3- (5-nitro-lH-indol-3-yl) maleimide;

2-(5-Methylthio-lH-indol-3-yl)-3-[5-methylthio-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-maleinimid;2- (5-methylthio-lH-indol-3-yl) -3- [5-methylthio-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -maleimide;

2-(4_/5-Dimethoxy-lH-indol-3-yl)-3-[4,5-dimerhoxy-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-maleinimid;2- (4 _/ 5-dimethoxy-1H-indol-3-yl) -3- [4,5-dimer-oxy-1- (3- (4-morpholino) -propyl) -1H-indol-3-yl] -maleimide ;

2-(5,6-Dimethoxy-lH-indol-3-yl)-3-[5,6-dimethoxy-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-maleinimid;2- (5,6-dimethoxy-lH-indol-3-yl) -3- [5,6-dimethoxy-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -maleimide ;

2-(5-Acetylamino-lH-indol-3-yl)-3-[5-acetylamino-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-maleinimid;2- (5-acetylamino-lH-indol-3-yl) -3- [5-acetylamino-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -maleimide;

2-(5-Amino-lH-indol-3-yl)-3-[5-amino-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-maleinimid;2- (5-amino-lH-indol-3-yl) -3- [5-amino-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -maleimide;

2-(5-Benzyloxy-lH-indol-3-yl)-3-[5-benzyloxy-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-maleinimid;2- (5-benzyloxy-lH-indol-3-yl) -3- [5-benzyloxy-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -maleimide;

__22L__ _22L _

2-(5-Brom-lH-indol-3-yl)-3-[5-brom-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-maleinimid;2- (5-bromo-lH-indol-3-yl) -3- [5-bromo-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -maleimide;

2-(5-Ch] rr-lH-indol-3-yl)-3-[5-chlor-l-(3-(2-nitroguanidino)propyl)-IH-indol-3-yl]-maleinimid;2- (5-chloro-1H-indol-3-yl) -3- [5-chloro-1- (3- (2-nitroguanidino) propyl) -1H-indol-3-yl] -maleimide;

2-(5-Fluor-lH-indol-3-yl)-3-[5-fluor-l-(3-(2-2- (5-fluoro-lH-indol-3-yl) -3- [5-fluoro-l- (3- (2-

nitroguanidi.no) propyl) -lH-indol-3-yl] -maleinimid;nitroguanidi.no) propyl) -1H-indol-3-yl] -maleimide;

2-(5-Hydroxy-lH-indol-3-yl)-3-[5-hydroxy-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-maleinimid;2- (5-hydroxy-lH-indol-3-yl) -3- [5-hydroxy-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -maleimide;

2-(5-Trifluormethyl-lH-indol-3-yl)-3-[5-trifluormethyl-l-(3-(: nitroguanidino)propyl)-lH-indol-3-yl]-maleinimid;2- (5-trifluoromethyl-1H-indol-3-yl) -3- [5-trifluoromethyl-1- (3- (nitroguanidino) propyl) -1H-indol-3-yl] -maleimide;

2-(5-Methoxy-lH-indol-3-yl)-3-[5-methoxy-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-maleinimid;2- (5-methoxy-lH-indol-3-yl) -3- [5-methoxy-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -maleimide;

2-(4,5-Methylendioxy-lH-indol-3-yl)-3-[4,5-methylendioxy-l-(. (2-nitroguanidino)propyl)-lH-indol-3-yl]-maleinimid;2- (4,5-methylenedioxy-1H-indol-3-yl) -3- [4,5-methylenedioxy-1- ((2-nitroguanidino) -propyl) -1H-indol-3-yl] -maleimide;

2-(5,6-Methylendioxy-lH-indol-3-yl)-3-[5,6-methylendioxy-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-maleinimid;2- (5,6-methylenedioxy-lH-indol-3-yl) -3- [5,6-methylenedioxy-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -maleimide ;

2-(5-Methyl-lH-indol-3-yl)-3-[5-methyl-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-maleinimid;2- (5-methyl-lH-indol-3-yl) -3- [5-methyl-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -maleimide;

2-(5-Nitro-lH-indol-3-yl)-3-[.^f5-nitro-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-maleinimid;2- (5-nitro-lH-indol-3-yl) -3- [. ^f 5-nitro-1- (3- (2-nitroguanidino) propyl) -1H-indol-3-yl] -maleimide;

2-(5-Methylthio-lH-indol-3-yl)-3-[5-methylthio-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-maleinimid;2- (5-methylthio-lH-indol-3-yl) -3- [5-methylthio-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -maleimide;

2-(4,5-Dimethoxy-lH-indol-3-yl)-3-[4,5-dimethoxy-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-maleinimid;2- (4,5-dimethoxy-lH-indol-3-yl) -3- [4,5-dimethoxy-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -maleimide ;

2-(5,6-Dimethoxy-lH-indol-3-yl)-3-[5,6-dimethoxy-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-maleinimid;2- (5,6-dimethoxy-lH-indol-3-yl) -3- [5,6-dimethoxy-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -maleimide ;

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2-(5-Acetylamino-lH-indol-J-ylj-3-[5-acetyiamino"l-(3-(lpiperidino)propyl)-lH-indcl-3-yl]-maleinimid;2- (5-acetylamino-lH-indole-J-YLJ-3- [5-acetylamino l- "(3- (lpiperidino) propyl) -lH-indcl-3-yl] -maleimide;

2-(5-Amino-lH-indol-3-yl)-3-[5-amino-l-(3-(lpiperidino)propyl)-lH-indol-3-yl]-maleinimid;2- (5-amino-lH-indol-3-yl) -3- [5-amino-l- (3- (lpiperidino) propyl) -lH-indol-3-yl] -maleimide;

2-(5-Benzyloxy-lH-indol-3-yl)-3-[5-benzyloxy-l-(3-(lpiperidino)propyl)-lH-indol-3-yl]-maleinimid;2- (5-benzyloxy-lH-indol-3-yl) -3- [5-benzyloxy-l- (3- (lpiperidino) propyl) -lH-indol-3-yl] -maleimide;

2-(5-Brom-lH-indol-3-yl)-3-[5-brom-l-(3-(1-piperidino)propyl)-lH-indol-3-yl]-maleinimid;2- (5-bromo-lH-indol-3-yl) -3- [5-bromo-l- (3- (1-piperidino) propyl) -lH-indol-3-yl] -maleimide;

2-(5-Chlor-lH-indol-3-yl)-3-[5-chlor-l-(3-(lpiperidino)propyl)-lH-indol-3-yl]-maleinimid;2- (5-chloro-lH-indol-3-yl) -3- [5-chloro-l- (3- (lpiperidino) propyl) -lH-indol-3-yl] -maleimide;

2-(5-Fluor-lH-indol-3-yl)-3-[5-fluor-l-(3-(lpiperidino)propyl)-lH-indol-3-yl]-maleinimid;2- (5-fluoro-lH-indol-3-yl) -3- [5-fluoro-l- (3- (lpiperidino) propyl) -lH-indol-3-yl] -maleimide;

2-(5-Hydroxy-lH-indol-3-yl)-3-[5-hydroxy-l-(3-(lpiperidino)propyl)-lH-indol-3-yl]-maleinimid;2- (5-hydroxy-lH-indol-3-yl) -3- [5-hydroxy-l- (3- (lpiperidino) propyl) -lH-indol-3-yl] -maleimide;

2-(5-Trifluormethyl-lH-indol-3-yl)-3-[5-trifluormethyl-l-(3-(lpiperidino)propyl)-lH-indol-3-yl]-maleinimid;2- (5-trifluoromethyl-lH-indol-3-yl) -3- [5-trifluoromethyl-l- (3- (lpiperidino) propyl) -lH-indol-3-yl] -maleimide;

2-(5-Methoxy-lH-indol-3-yl)-3-[5-methoxy-l-(3-(lpiperidino)propyl)-lH-indol-3-yl]-maleiniraid;2- (5-methoxy-lH-indol-3-yl) -3- [5-methoxy-l- (3- (lpiperidino) propyl) -lH-indol-3-yl] -maleiniraid;

2-(4_/5-Methylendioxy-lH-indol-3-yl)-3~[4,5-methylendioxy-l-(3-(1-piperidino)propyl)-lH-indol-3-yl]-maleinimid;2- (4 _/ 5-Methylenedioxy-1H-indol-3-yl) -3- [4,5-methylenedioxy-1- (3- (1-piperidino) propyl) -1H-indol-3-yl] -maleimide ;

2-(5,6-Methylendioxy-lH-indol-3-yl)-3-[5,6-methylendioxy-l-(3-(1-piperidino)propyl)-lH-indol-3-yl]-maleinimid;2- (5,6-methylenedioxy-lH-indol-3-yl) -3- [5,6-methylenedioxy-l- (3- (1-piperidino) propyl) -lH-indol-3-yl] -maleimide ;

2-(5-Methyl-lH-indol-3-yl)-3-[5-methyl-l-(3-(lpiperidino)propyl)-lH-indol-3-yl]-maleinimid;2- (5-methyl-lH-indol-3-yl) -3- [5-methyl-l- (3- (lpiperidino) propyl) -lH-indol-3-yl] -maleimide;

2-(5-Nitro-lH-indol-3-yl)-3-[5-nitro-l-(3-(lpiperidino)propyl)-lH-indol-3-yl]-maleinimid;2- (5-nitro-lH-indol-3-yl) -3- [5-nitro-l- (3- (lpiperidino) propyl) -lH-indol-3-yl] -maleimide;

-:>23--:> 23-

2-(5-Methylthio-lH-indol-3-yl)-3-[5-methylthio-l-(3-(lpiperidino)propyl)-lH-indol-3-yl]-maleinimid;2- (5-methylthio-lH-indol-3-yl) -3- [5-methylthio-l- (3- (lpiperidino) propyl) -lH-indol-3-yl] -maleimide;

2-(4,5-Dimethoxy-lH-indol-3-yl)-3-[4,5-dimethoxy-l-(3-(1-piperidino)propyl)-lH-indol-3-yl]-maleinimid;2- (4,5-dimethoxy-lH-indol-3-yl) -3- [4,5-dimethoxy-l- (3- (1-piperidino) propyl) -lH-indol-3-yl] -maleimide ;

2-(5,6-Dimethoxy-lH-indol-,-yl)-3-[5,6-dimethoxy-l-(3-(1- piperidino)propyl)-lH-indol-3-yl]-maleinimid;2- (5,6-Dimethoxy-1H-indol-1-yl) -3- [5,6-dimethoxy-1- (3- (1-piperidino) -propyl) -1H-indol-3-yl] -maleimide ;

2-[l-(3-(Ajnidinothio)propyl)-4-dimethylamino-lH-indol-3-yl]-3-(lH-indol-3-yi)-maleinimid;2- [l- (3- (Ajnidinothio) propyl) -4-dimethylamino-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-(Amidinothio)propyl)-5-dimethylamino-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3- (amidinothio) propyl) -5-dimethylamino-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(3-(Amidinothio)propyl)-6-dimethylamino-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [l- (3- (amidinothio) propyl) -6-dimethylamino-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[l-(3-(Amidinothio)propyl)-7-dimethylamino-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (3- (amidinothio) propyl) -7-dimethylamino-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-tl-(2-Aminoethyl)-4-dimethylamino-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2-tl (2-aminoethyl) -4-dimethylamino-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(2-Aminoethyl)-5-dimethylamino-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (2-aminoethyl) -5-dimethylamino-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(2-Aminoethyl)-6-dimethylamino-lH-indol-3-yl]-3-(lH-indol-32- [l- (2-aminoethyl) -6-dimethylamino-lH-indol-3-yl] -3- (lH-indol-3

2-[l-(2-Aminoethyl)-7-dimethylamino-lH-indol-3-yl]-3-(lh-indol-3-yl)-maleinimid;2- [l- (2-aminoethyl) -7-dimethylamino-lH-indol-3-yl] -3- (lh-indol-3-yl) maleimide;

2-[1-(3-Aminopropyl)M-dimethylamino-lH-indol-S-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (3-aminopropyl) M-dimethylamino-lH-indol-S-yl] -3- (IH-indol-3-yl) maleimide;

2-[1-(3-Aminopropyl)-S-dimethylamino-lH-indol-S-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (3-aminopropyl) -S-dimethylamino-lH-indol-S-yl] -3- (IH-indol-3-yl) maleimide;

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2-[l-(3-Aminopropyl) -e-dimethylanäno-lH-iiidol-S-yl]-3-(1H-indol-3-yl)-maleinimid;2- [1- (3-aminopropyl) -e-dimethylananono-1H-idol-S-yl] -3- (1H-indol-3-yl) -maleimide;

2- [1-(3-Aminopropyl)-V-dimethylamino-lH-indol-S-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (3-aminopropyl) -V-dimethylamino-1H-indol-S-yl] -3- (IH-indol-3-yl) -maleimide;

(±) 2-[l-(3-Ethoxy-2-hydroxypropyl)-4-dimethylamino-lH-indol-3 " yl]-3-(lH-indol-3-yl)-maleinimid;(±) 2- [1- (3-ethoxy-2-hydroxypropyl) -4-dimethylamino-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±) 2-[l-(3-Ethoxy-2-hydroxypropyl)-5-dimethylamino-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) 2- [1- (3-ethoxy-2-hydroxypropyl) -5-dimethylamino-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±) 2-[l-(3-Ethoxy-2-hydroxypropyl)-6-dimethylamino-lH"indol'3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) 2- [1- (3-ethoxy-2-hydroxypropyl) -6-dimethylamino-1H "indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±) 2-[l-(3-Ethoxy-2-hydroxypropyl)-V-dimethylainino-lH-indol-S-yl]-3-(lH-indol-3-yl)-maleinimid;(±) 2- [1- (3-ethoxy-2-hydroxypropyl) -V-dimethyl-amino-1H-indol-S-yl] -3- (1H-indol-3-yl) -maleimide;

2-[l-(2-Diethylaminoethyl)-4-dimethylamino-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (2-diethylaminoethyl) -4-dimethylamino-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-[l-(2-Diethylaminoethyl)-5-dimethylamino-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [l- (2-diethylaminoethyl) -5-dimethylamino-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

2-fl-(2-Diethylaminoethyl)-6-dimethylamino-lH-indol-3-yl]-3-(LH-indol-3-yl)-maleinimid;2-fl- (2-diethylaminoethyl) -6-dimethylamino-lH-indol-3-yl] -3- (lh-indol-3-yl) maleimide;

2 -[l-(2~Diethylaminoethyl)-7-dimethylamino-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2 - [1- (2-diethylaminoethyl) -7-dimethylamino-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±) 2-[l-(3-Diethylamino-2-hydroxypropyl)-4-dimethylamino-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;(±) 2- [1- (3-diethylamino-2-hydroxypropyl) -4-dimethylamino-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±) 2-[1-(3-Diethylamino-2-hydroxypropyl)-5-dimethylamino-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) 2- [1- (3-diethylamino-2-hydroxypropyl) -5-dimethylamino-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±) 2-[l-(3-Diethylamino-2-hydroxypropyl)-6-dimethylamino"lH-indol-3-yl]«3-(lH-indol-3-yl)-maleinimid;(±) 2- [1- (3-diethylamino-2-hydroxypropyl) -6-dimethylamino "1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

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(±) 2-[l-(3-Diethylamino-2-hydroxypropyi)-7-dimethylamino-iH-inaol-3-yl] -3- (lH-indol-3-yl) -maleinimid;(±) 2- [1- (3-diethylamino-2-hydroxypropyl) -7-dimethylamino-iH-inaol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[1-(3-Ethylaminopropyl)-4-dimethylamino-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (3-ethylaminopropyl) -4-dimethylamino-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[1-(3-Ethylaminopropyl)-5-dimethylamino-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (3-ethylaminopropyl) -5-dimethylamino-lH-indol-3-yl] -3- (IH-indol-3-yl) maleimide;

2-[l-(3-Ethylaminopropyl)-ö-dimethylamino-lH-indol-S-yl]-3-(IH-indol-3-yl)-maleinimid;2- [l- (3-ethylaminopropyl) -o-dimethylamino-lH-indol-S-yl] -3- (IH-indol-3-yl) maleimide;

2-[l-(3-Ethylaminopropyl)-7-dimethylamino-lH-indol-3-yi]-3-(IH-indol-3-yl)-iaaleinimid;2- [l- (3-ethylaminopropyl) -7-dimethylamino-lH-indol-3-yl] -3- (IH-indol-3-yl) -iaaleinimid;

(±) 2-[l-(2-Hydroxy-3-dimethylaminopropyl)-4-dimethylamino-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) 2- [1- (2-hydroxy-3-dimethylaminopropyl) -4-dimethylamino-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±) 2-[l-(2-Hydroxy-3-dimethylaminopropyl)-5-dimethylamino-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) 2- [1- (2-hydroxy-3-dimethylaminopropyl) -5-dimethylamino-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+) 2-tl-(2-Hydroxy-3-dimethylaminopropyl)-6-dimethylaraino-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(+) 2-tl- (2-hydroxy-3-dimethylaminopropyl) -6-dimethyl-amino-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±) 2-[l-(2-Hydroxy-3-dimethylaminopropyl)-7-dimethylaraino-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) 2- [1- (2-hydroxy-3-dimethylaminopropyl) -7-dimethyl-1-amino-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±) 2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-4-diiuethylamino-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) 2- [1- (2-hydroxy-3- (4-morpholino) propyl) -4-diethylamino-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±) 2-[l-(2-Hydroxy-3-(4-morpholino}propyl)-5-dimethylamino-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) 2- [1- (2-hydroxy-3- (4-morpholino) propyl) -5-dimethylamino-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±) 2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-6-dimethylamino-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) 2- [1- (2-hydroxy-3- (4-morpholino) propyl) -6-dimethylamino-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±) 2-[l-(2-Hydroxy-3-(4-morpholino)propyl)-7-dimethylamino-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) 2- [1- (2-hydroxy-3- (4-morpholino) propyl) -7-dimethylamino-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

-226--226-

(±) 2-[l-(2-Hydroxy-3-^1-piperidino)propyl)-4-dimethylamine-IH-indol-3~yl]-3-(lH-indol-3-yl)-maleinimid;(±) 2- [1- (2-hydroxy-3- (1-piperidino) propyl) -4-dimethylamine-IH-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±) 2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-5-dimethylamino-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) 2- [1- (2-hydroxy-3- (1-piperidino) propyl) -5-dimethylamino-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±) 2-[1-(2-Hydroxy-3-(1-piperidino)propyl)-6-dimethylamino-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) 2- [1- (2-hydroxy-3- (1-piperidino) propyl) -6-dimethylamino-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±) 2-[l-(2-Hydroxy-3-(1-piperidino)propyl)-7-dimethylamino-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) 2- [1- (2-Hydroxy-3- (1-piperidino) propyl) -7-dimethylamino-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±) 2-[l-(2_/3-Dihydroxypropyl)-4-dimethylamino-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) 2- [1- (2 _/ 3-dihydroxypropyl) -4-dimethylamino-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+) 2-[1-(2,3-Dihydroxypropyl)-ö-dimethylamino-lH-indol-S-yl]-3-(lH-indol-3-yl)-maleinimid;(+) 2- [1- (2,3-dihydroxypropyl) -α-dimethylamino-1H-indol-S-yl] -3- (1H-indol-3-yl) -maleimide;

(±) 2-[1-(2,3-Dihydroxypropyl)-6-dimethylamino-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;(±) 2- [1- (2,3-dihydroxypropyl) -6-dimethylamino-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±) 2-[1-(2,3-Dihydroxypropyl)-T-dimethylaraino-lH-indol-S-yl]-3-(lH-indol-3-yl)-maleinimid;(±) 2- [1- (2,3-dihydroxypropyl) -T-dimethylaraino-1H-indol-S-yl] -3- (1H-indol-3-yl) -maleimide;

2- [ 1-(3-Hydroxypropyl)-4-dimethylamino-lH-indol-3-yl]-3-(IH-indol-3-yl)-maleinimid;2- [1- (3-hydroxypropyl) -4-dimethylamino-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-[1-(3-Hydroxypropyl)-5-dimethylamino-lH-indol-3-y1]-3-(IH-indol-3-yl)-maleinimid;2- [1- (3-hydroxypropyl) -5-dimethylamino-lH-indol-3-y1] -3- (IH-indol-3-yl) maleimide;

2-[l-(3-Hydroxypropyl)-e-dimethylamino-lH-indol-S-yl]-3-(IH-indol-3-yl)-maleinimid;2- [l- (3-hydroxypropyl) -e-dimethylamino-lH-indol-S-yl] -3- (IH-indol-3-yl) maleimide;

2- [ 1-(3-Hydroxypropyl)-V-dimethylamino-lH-indol-S-yl]-3~(IH-indol-3-yl)-maleinimid;2- [1- (3-hydroxypropyl) -V-dimethylamino-1H-indol-S-yl] -3- (1H-indol-3-yl) -maleimide;

2-(lH-Indol-3-yl)-3-[l-(3-isothiocyanatopropyl)-4-dimethylamino-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [l- (3-isothiocyanatopropyl) -4-dimethylamino-lH-indol-3-yl] -maleimide;

-227--227-

2-(lH-Indol-3-yl) -3-[l-(3-isothiocyanat:opropyl) -5-dimethylamino-lH-indol-3-yl]-maleinimid;2- (1H-indol-3-yl) -3- [1- (3-isothiocyanato-o-propyl) -5-dimethylamino-1H-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[1-(3-isothiocyanatopropyl)-6-dimethylamino-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [1- (3-isothiocyanatopropyl) -6-dimethylamino-lH-indol-3-yl] -maleimide;

2-(lH-Indol-3~yl)-3-[l-(3-isothiocyanatopropyl)-7-. dimethylamino-lH-indol-3-yl]-maleinimid;2- (lH-Indol-3 ~ yl) -3- [l- (3-isothiocyanatopropyl) -7-. dimethylamino-lH-indol-3-yl] -maleimide;

(±) 2-(lH-Indol-3-yl)-3-[l-(2-methoxy-3-dimethylaminopropyl)-4-dimethylamino-lH-indol-3-yl]-maleinimid;(±) 2- (1H-indol-3-yl) -3- [1- (2-methoxy-3-dimethylaminopropyl) -4-dimethylamino-1H-indol-3-yl] -maleimide;

(±) 2-(lH-Indol-3-yl)-3-[l-(2-methoxy-3-dimethylaminopropyl)-5-dimethylamino-lH-indol-3-yl]-maleinimid;(±) 2- (1H-indol-3-yl) -3- [1- (2-methoxy-3-dimethylaminopropyl) -5-dimethylamino-1H-indol-3-yl] -maleimide;

(±) 2-(lH-Indol-3-yl)-3-[l-(2-methoxy-3-dimethylaminopropyl)-6-dimethylamino-lH-indol-3-yl]-maleinimid;(±) 2- (1H-indol-3-yl) -3- [1- (2-methoxy-3-dimethylaminopropyl) -6-dimethylamino-1H-indol-3-yl] -maleimide;

(±) 2-(lH-Indol-3~yl)-3-[l-(2-methoxy-3-dimethylaminopropyl)-T-dimethylamino-lH-indol-3-yl]-maleinimid;(±) 2- (lH-Indol-3 ~ yl) -3- [l- (2-methoxy-3-dimethylaminopropyl) -T- dimethylamino-lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[4-dimethylamino-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [4-dimethylamino-l- (2-dimethylaminoethyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[5-dimethylamino-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [5-dimethylamino-l- (2-dimethylaminoethyl) -lH-indol-3-yl] -maleimide;

2~(lH-Indol-3-yl)-3-[6-dimethylamino-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-maleinimid;2 ~ (lH-Indol-3-yl) -3- [6-dimethylamino-l- (2-dimethylaminoethyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[7-dimethylamino-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [7-dimethylamino-l- (2-dimethylaminoethyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[4-dimethylamino-l-(3-dimethylaminopropyl) lH-indol-3-yl]-maleinimid;2- (1H-indol-3-yl) -3- [4-dimethylamino-1- (3-dimethylaminopropyl) -1H-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[5-dimethylaraino-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [5-dimethylaraino-l- (3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide;

-228--228-

2- (lH-Indol-3-yl) -S-fe-diiaethylaiiiino-l- (3'-dimethylaminopropyl) lH-indol-3-yl]-maleinimid;2- (1H-indol-3-yl) -S-Fe-di-ethyl-ethyliino-1- (3'-dimethylaminopropyl) -1H-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl) -3-[7-dimethylamino-l-(3-dimethylaminopropy].) lH-indol-3-yl]-maleinimid;2- (1H-indol-3-yl) -3- [7-dimethylamino-1- (3-dimethylaminopropy].) -1H-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[4-dimethy¹amino-1-(3-methylaminopropyl)-lH-indol-3-yl]-maleinimid;2- (1H-indol-3-yl) -3- [4-dimethyl- ^1- amino-1- (3-methylaminopropyl) -1H-indol-3-yl] -maleimide;

2-(lH-lndol-3-yl)-3-[5-dimethylamino-l-(3-methylaminopropyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [5-dimethylamino-l- (3-methylaminopropyl) -lH-indol-3-yl] -maleimide;

2-(1H-Indol-3-yl)-3-[6-dimethylamino-1-(3-methylaminopropy1)-lH-indol-3-yl]-maleinimid;2- (1H-indol-3-yl) -3- [6-dimethylamino-1- (3-methylaminopropy1) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[7-dimethylamino-l-(3-methylaminopropyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [7-dimethylamino-l- (3-methylaminopropyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[4-dimethylamino-l-(3-(4-morpholino)propyl)-IH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [4-dimethylamino-l- (3- (4-morpholino) propyl) -IH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[5-dimethylamino-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [5-dimethylamino-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[6-dimethylamino-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [6-dimethylamino-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -maleimide;

2-(lH-indol-3-yl)-3-[7-dimethylamino-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [7-dimethylamino-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[4-dimethylamino-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [4-dimethylamino-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[5-dimethylamino-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [5-dimethylamino-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[6-dimethylamino-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [6-dimethylamino-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -maleimide;

-229--229-

2-(lH-Indol-3-yl)-3-[7-diiiiethylaiuino-i-( j-(2-nitroguanidino)propyl)-lH-indol-3-yl]-maleiniraid;2- (1H-indol-3-yl) -3- [7-dimethylethyl-i-i- (1- (2-nitroguanidino) -propyl) -1H-indol-3-yl] -maleiniride;

2-(lH-Indol-3-yl)-3-[4-dimethylamino-l-(3-(1-piperidino)propyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [4-dimethylamino-l- (3- (1-piperidino) propyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[5-dimethylamino-i-(3-(l-.piperidino)propyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [5-dimethylamino-i- (3- (l-.piperidino) propyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[6-dimethylamino-l-(3-(1-piperidino)propyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [6-dimethylamino-l- (3- (1-piperidino) propyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[7-dimethylamino-l-(3-(lpiperidino)propyl)-lH-indol-3-yl]-maleinimid;2- (lH-indol-3-yl) -3- [7-dimethylamino-l- (3- (lpiperidino) propyl) -lH-indol-3-yl] -maleimide;

2-[l-(3-(Amidinothio)propyl)-5-dimethylamino-lH-indol-3-yl]-3-(5-dimethylamino-lH-indol-3-yl)-maleinimid;2- [l- (3- (amidinothio) propyl) -5-dimethylamino-lH-indol-3-yl] -3- (5-dimethylamino-lH-indol-3-yl) maleimide;

2-[1-(2-Aminoethyl)-S-dimethylamino-lH-indol-S-yl]-3-(5-dimethylamino-lH-indol-3-yl)-maleinimid;2- [1- (2-aminoethyl) -S-dimethylamino-lH-indol-S-yl] -3- (5-dimethylamino-lH-indol-3-yl) maleimide;

2-[1-(3-Aminopropyl)-5~dimethylamino-lH-indol-3-yl]-3-(5-dijnethylamino-lH-indol-3-yl)-maleinimid; 2- [ 1- (3-aminopropyl) -5-dimethylamino-1H-indol-3-yl] -3- (5-di-methylamino-1H-indol-3-yl) -maleimide;

(±) 2-[l-(3-Ethoxy-2-hydroxypropyl)-S-dimethylamino-lH-indol-S-yl ]-3-(5-dimethylamino-lH-indol-3-yl)-maleinimid.;(±) 2- [1- (3-Ethoxy-2-hydroxypropyl) -S-dimethylamino-1H-indol-S-yl] -3- (5-dimethylamino-1H-indol-3-yl) -maleimide;

2-[1-(2-Diethylaminoethyl)-S-dimethylamino-lH-indol-S-yl]-3-(5· dimethylamino-lH-indol-3-y¹)-maleinimid;2- [1- (2-diethylaminoethyl) -S-dimethylamino-lH-indol-S-yl] -3- (5 x dimethylamino-lH-indol-3-y ¹⁾ maleimide;

(±) 2-[l-(3-Diethylamino-2-hydroxypropyl)-5-dimethylamino-lH-indol-3-yl]-3-(5-dimethylamino-lH-indol-3-yl)-maleinimid;(±) 2- [1- (3-diethylamino-2-hydroxypropyl) -5-dimethylamino-1H-indol-3-yl] -3- (5-dimethylamino-1H-indol-3-yl) -maleimide;

2-[l-(3-Ethylaminopropyl)-S-dimethylamino-lH-indol-3-yl)-maleinimid;2- [l- (3-ethylaminopropyl) -S-dimethylamino-lH-indol-3-yl) maleimide;

(±) 2-[l-(2-Hydroxy-3-dimethylaminopropyl)-5-dimethylamino-lH indol-3-yl]-3-(5-dimethylamino-lH-indol-3-yl)-maleinimid;(±) 2- [1- (2-hydroxy-3-dimethylaminopropyl) -5-dimethylamino-1H-indol-3-yl] -3- (5-dimethylamino-1H-indol-3-yl) -maleimide;

29797ο __23G_ 29797ο _ _23G _

(±) 2-[l-(2-Hydroxy-3-(4-norphclino^propyl)-5-dimethylamino-lH-indol-3-yl]-3-(5-dimethylamino-lH-indol-3-yl)-maleinimid;(±) 2- [1- (2-Hydroxy-3- (4-norphyclino-propyl) -5-dimethylamino-1H-indol-3-yl] -3- (5-dimethylamino-1H-indol-3-yl ) maleimide;

(±) 2-[l-(2-Hydroxy-3-(l-piperidino)propyl)-5-dimethylamino-lH-indol-3-yl]-3-(S-dimethylamino-lH-indol-S-yl)-maleinimid;(±) 2- [1- (2-Hydroxy-3- (1-piperidino) propyl) -5-dimethylamino-1H-indol-3-yl] -3- (S -dimethylamino-1H-indol-5-yl ) maleimide;

(+) 2-[l-(2,3-Dihydroxypropyl)-5-dimethylamino-lH-indol-3-yl]-3-(5-dimethylamino-lH-indol-3-yl) -maleinimid;(+) 2- [1- (2,3-dihydroxypropyl) -5-dimethylamino-1H-indol-3-yl] -3- (5-dimethylamino-1H-indol-3-yl) -maleimide;

2-[l-(3-Hydroxypropyl)-5-dimethylamino-lH-indol-3-yl]-3-(5-dimethylamino-lH-indol-3-yl)-maleinimid;2- [l- (3-hydroxypropyl) -5-dimethylamino-lH-indol-3-yl] -3- (5-dimethylamino-lH-indol-3-yl) maleimide;

2-[l-(3-Isothiocyanatopropyl)-5-dimethylamino-lH-irdol-3-yl]-3-(5-dimethylamino-lH-indol-3-yl)-maleinimid;2- [l- (3-isothiocyanatopropyl) -5-dimethylamino-lH-irdol-3-yl] -3- (5-dimethylamino-lH-indol-3-yl) maleimide;

(i) 2-[1-(2-Methoxy-3-dimethylaminopropyl)-5-dimethy]amino-lH-indol-3-yl]-3-(5-dimethylamino-lH-indol-3-yl)-maleinimid;(i) 2- [1- (2-Methoxy-3-dimethylaminopropyl) -5-dimethyl] amino-1H-indol-3-yl] -3- (5-dimethylamino-1H-indol-3-yl) -maleimide ;

2-(5-Dimethylamino-lH-indol-3-yl)-3-[5-dimethylamino-l-(2-dimethylaminoethyl)-lH-indol-3-yl]-maleinimid;2- (5-Dimethylamino-lH-indol-3-yl) -3- [5-dimethylamino-l- (2-dimethylaminoethyl) -lH-indol-3-yl] -maleimide;

2-(5-Dimethylamino-lH-indol-3-yl)-3-[5-dimethylamino-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid;2- (5-Dimethylamino-lH-indol-3-yl) -3- [5-dimethylamino-l- (3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide;

2-(5-Dimethylamino-lH-indol-3-yl)-3-[5-dimethylamino-l~(3-methylaminopropyl)-lH--indol-3-yl] -maleinimid;2- (5-dimethylamino-1H-indol-3-yl) -3- [5-dimethylamino-1 - (3-methylaminopropyl) -1H-indol-3-yl] -maleimide;

2-(5-Dimethylaminu-lH-indol-3-yl)-3~[5-dimethylamino-l-(3-(4-raorpholino)propyl)-iK-indol-3-yl]-maleinimid;2- (5-Dimethylaminu-lH-indol-3-yl) -3 ~ [5-dimethylamino-l- (3- (4-raorpholino) propyl) -ik-indol-3-yl] -maleimide;

2-(5-Dimethylamino-lH-indol-3-yl)-3-[5-dimethylamino-l-(3-(2-nitroguanidino)propyl)-lH-indol-3-yl]-maleinimid;2- (5-Dimethylamino-lH-indol-3-yl) -3- [5-dimethylamino-l- (3- (2-nitroguanidino) propyl) -lH-indol-3-yl] -maleimide;

2-(5-Dimethylamino-lH-indol-3-yl)-3-[5-dimethylamino-l-(3-(lpiperidino)propyl)-lH-indol-3-yl]-maleinimid.2- (5-Dimethylamino-lH-indol-3-yl) -3- [5-dimethylamino-l- (3- (lpiperidino) propyl) -lH-indol-3-yl] -maleimide.

M 9M 9

DEUTSCHES PATENTAMTGERMAN PATENT OFFICE

E η dE η d

der Aktthe act

A 9609A 9609

Claims

Patentansprücheclaims

1. Verfahren zur Herstellung von Bis-(lH-iiidol-3-yl) maleinimid-Derivaten der allgemeinen Formel I,1. A process for the preparation of bis (1H-2-idol-3-yl) maleimide derivatives of general formula I,

(D(D

in welcher R¹ und R² gleich oder verschieden sind und Wasserstoff, eine geradkettige oder verzweigte Aikylgruppe Y _δ mit 1 bis 18 C-Atomen, eine unsubstituierte oder mit bis zu drei C₁_₄-Alkylgruppen, C₁_₄-Alkoxygruppen oder Halogenatomen substituierte Benzylgruppe, eine Aminoalkylgruppe mit bis zu 12 C-Atomen, die am Stickstoffatom unsubstituiert oder mono- oder disubstituiert durch Benzyl- oder Alkylreste mit 1 bis 4 C-Atomen ist, oder bei der die Substituenten zusammen mit dem Stickstoffatom einen heterozyklischen Ring mit 3 bis 6 C-Atomen bilden, wobei die Alkylkette durch weitere C^^-Alkylreste, eine Hydroxygruppe oder eine C_1-4-AIkOXYg]TUpPe substituiert sein kann, eine Amidinothioalkylgruppe mit bis zu 12 C-Atomen, eine Nitroguanidinoalkylgruppe mit bis zu 12 C-Atomen, eine Isothiocyanatoalkylgruppe mit bis zu 12 C-Atomen, einen Epoxyalkylrest mit bis zu 6 C-Atomen, einen Alkoxycarbonylalky.lrest mit bis zu 6 C-Atomen, einen Rest CH₂-CO-NR¹¹R¹², bei dem R¹¹ und R¹² gleich oder verschieden sind und für'Wasserstoff, eine Aikylgruppe mit 1 bis 6 C-Atomen oder eine Benzylgruppe stehen, einen Halogenalkyl- oder Hydroxyalkylrest, der gegebenenfalls mit einem Halogenatom oder mit einer Hydroxygruppe substituiert sein kann, oder einen gegebenenfalls mit bis zu drei Hydroxygruppen substituierten Alkoxyalkylrest mit jeweils bis zu 6 C-Atomen, eine Acylgmppe rait I bis 4 C-Atomen, oder einen Glycosidrest bedeuten, R³, R⁴, R⁵, R⁶, R⁷, R⁸, R⁹ und R¹⁰ unabhängig voneinander Wasserstoff, C_1-4 in which R ¹ and R ² are identical or different and are hydrogen, a linear or branched Aikylgruppe Y _δ having 1 to 18 carbon atoms, an unsubstituted or with up to three C ₁ _ ₄ alkyl, C ₁ _ ₄ alkoxy groups or Halogen atoms substituted benzyl group, an aminoalkyl group having up to 12 carbon atoms which is unsubstituted or mono- or disubstituted by benzyl or alkyl radicals having 1 to 4 carbon atoms on the nitrogen atom, or in which the substituents together with the nitrogen atom is a heterocyclic ring with Form 3 to 6 carbon atoms, wherein the alkyl chain may be substituted by further C ^^ - alkyl radicals, a hydroxy group or a C _1-4 -AIkOXYg] TUpPe, an amidinothioalkyl group having up to 12 carbon atoms, a Nitroguanidinoalkylgruppe with up to 12 C atoms, an isothiocyanatoalkyl group having up to 12 C atoms, an epoxyalkyl radical having up to 6 C atoms, a Alkoxycarbonylalky.lrest having up to 6 C-atoms, a radical CH ₂ -CO-NR ¹¹ R ¹² , at the R ¹¹ u and R ^{12 are the} same or different and are hydrogen, an Aikylgruppe having 1 to 6 carbon atoms or a benzyl group, a haloalkyl or hydroxyalkyl radical which may optionally be substituted by a halogen atom or a hydroxy group, or optionally with bis to three hydroxy-substituted alkoxyalkyl having in each case up to 6 carbon atoms, an Acylgmppe rait I to 4 C-atoms, or a glycoside radical, R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ and R ^{10 are} independently hydrogen, C _1-4

C_1-4-ACyIoXy, Halogen, eine Nitrogruppe, eine unsubstituierte oder durch Benzyl oder Alkylreste mit 1 bis 4 C-Atomen mono- oder disubstituierte Aminogruppe, eine Benzyloxygruppe, eine Hydroxygruppe, eine Aminoalkoxygruppe mit bis zu 12 C-Atomen, die am Stickstoffatom unsubstituiert •oder mono- oder disubstituiert durch Benzyl- oder Alkylreste mit 1 bis 4 C-Atomen sein kann oder bei der die Substituenten zusammen mit dem Stickstoffatom einen heterozyklischen Ring mit 3 fei.?¹ ο C-Atomen bilden, wobei die Alkylkette durch weitere C₁_₄-Alkylreste, eine Hydroxygruppe oder eine C_1-^-Alkoxygruppe substituiert sein kann, eine Trifluormetl·.· '.gruppe oder zwei benachbarte Reste zusammen eine Methyle,^sdioxygruppe bedeuten, mit der Maßgabe, daß nicht alle Rnste R¹ bis R¹⁰ gleich Wasserstoff sind oder, wenn P."' 'jzw. R⁴ und R⁹ gleich Hydroxyl sind, alle übrigen Reste nicht gleich Wasserstoff sind, und deren pharmakologisch unbedenklichen Salzen, dadurch gekennzeichnet, daß man entwederC _1-4 -alkyl, halogen, a nitro group, an unsubstituted or monosubstituted or disubstituted by benzyl or alkyl radicals having 1 to 4 carbon atoms, a benzyloxy group, a hydroxy group, an aminoalkoxy group having up to 12 carbon atoms, the Nitrogen atom unsubstituted or mono- or disubstituted by benzyl or alkyl radicals having 1 to 4 carbon atoms, or in which the substituents together with the nitrogen atom, a heterocyclic ring with 3 fei. Form ¹ ο C-atoms, wherein the alkyl chain may be substituted by further C ₁ _ ₄ alkyl, a hydroxy group or a C ₁ ^ alkoxy group, a Trifluormetl ·. · '.Group or two adjacent radicals together form a methyls, ^s dioxy group, provided that not all of R ¹ to R ¹⁰ are hydrogen or, when P 1, R ⁴ and R ⁹ are hydroxyl, all other radicals are not the same, and their pharmacologically acceptable Salts, characterized in that either

A) ein Dibroinmaleinimid der allgemeinen Formel II,A) a dibroin maleimide of the general formula II,

(A)(A)

^K ' IO ι ^K 'IO ι

233233

in welcher R⁷, R⁸, R⁹ und R¹⁰ die oban genannte Bedeutung haben, nicht jedoch Hydroxy oder Acyloxy sind, nach an sich bekannten Methoden umsetzt, und das erhaltene Produkt der allgemeinen Formel III,in which R ⁷ , R ⁸ , R ⁹ and R ¹⁰ are as defined above but are not hydroxy or acyloxy, are reacted according to methods known per se, and the resulting product of the general formula III,

(III)(III)

bei der R¹ Wasserstoff bedeutet, gegebenenfalls am Indolstickstoff mit einem Alkylierungsmittel R^3--X, wobei R mit Ausnahme von Wasserstoff die oben genannten Bedeutungen hat, nicht jedoch funktionelle Gruppen enthält, die die nachfolgenden Umsetzungen stören würden, und X für eine leicht austretende Gruppe wie Chlor oder Brom steht, in an sich bekannter Weise alkyliert, wobei ein Produkt der allgemeinen Formel III erhalten wird, bei dem R¹ verschieden von Wasserstoff ist, und anschließend Produkt III mit einem Indolgrignardreagenz der allgemeinen Formel (B),wherein R ^{1 is} hydrogen, optionally at the indole nitrogen with an alkylating agent R ^3- -X, wherein R except for hydrogen has the abovementioned meanings, but does not contain functional groups that would disturb the subsequent reactions, and X is a readily exiting Group such as chlorine or bromine, alkylated in a conventional manner to give a product of general formula III is obtained in which R ^{1 is} different from hydrogen, and then product III with a Indolgrignardreagenz the general formula (B),

(B)(B)

in welcher R³, R⁴, R⁵ und R⁶ die oben genannte Bedeutung haben, nicht jedoch Hydroxy oder Acyloxy sind, umsetzt und gegebenenfalls anschließend mit einem Alkylierungsmittel der allgemeinen Formel R²-X, in der R² mit Ausnahme von Wasserstoff die oben genanntenin which R ³ , R ⁴ , R ⁵ and R ^{6 have} the abovementioned meaning, but are not hydroxy or acyloxy, and if appropriate subsequently reacted with an alkylating agent of the general formula R ² -X, in which R ² with the exception of hydrogen mentioned above

Bedeutungen hat, nicht jedoch funktioneile Gruppen enthält, die die nachfolgenden Umsetzungen stören wurden, und X die oben genannten Bedeutungen hat, alkyliert zu einem Produkt der allgemeinen formel IV,Has meanings but does not contain functional groups that would interfere with the subsequent reactions, and X has the meanings given above, alkylated to a product of general formula IV,

(IV)(IV)

oderor

B) ein Produkt der allgemeinen Formel VB) a product of general formula V

(V)(V)

(B)(B)

Mg HaiMg shark

1010

1515

in welcher R³, R⁴, R⁵ und R⁶ die oben genannte Bedeutung haben, nicht jedoch Hydroxy oder Acyloxy sind, umsetzt und gegebenenfalls anschließend mit einem Alkylierungsmittel der allgemeinen Formel R²-X, in der R² mit Ausnahme von Wasserstoff die oben genannten Bedeutungen hat, nicht jedoch funktionelle Gruppen enthält, die die nachfolgenden Umsetzungen stören würden, und X die oben genannte Bedeutung hat, alkyliert zu einem Produkt der allgemeinen Formel VIin which R ³ , R ⁴ , R ⁵ and R ^{6 have} the abovementioned meaning, but are not hydroxy or acyloxy, and if appropriate subsequently reacted with an alkylating agent of the general formula R ² -X, in which R ² with the exception of hydrogen has the abovementioned meanings but does not contain functional groups which would disturb the subsequent reactions, and X has the abovementioned meaning, alkylated to give a product of the general formula VI

(VI)(VI)

20 25 3020 25 30

wonach man die geschützte Indolgruppe in die freie Indolgruppe und die substituierte Imidgruppe in die unsubstituierte Imidgruppe der Verbindung der allgemeinen Formel I überführt, wobei R¹ für Wasserstoff steht, und R² bis R¹⁰ die oben genannte Bedeutung haben,according to which the protected indole group is converted into the free indole group and the substituted imide group into the unsubstituted imide group of the compound of the general formula I, where R ^{1 is} hydrogen, and R ² to R ^{10 have} the abovementioned meaning,

oderor

3535

236236

(ID(ID

Brbr

1010

in welcher Z eine geeignete abspaltbare Schutzgruppe ist, mit einem Überschuß an Indolgrignardreagenz der allgemeinen Formel (A)in which Z is a suitable cleavable protecting group, with an excess of Indolgrignardreagenz the general formula (A)

1515

2020

.'0.'0

N I Mg HaiN I Mg shark

(A)(A)

25302530

in welcher R⁷, R⁸, R⁹ und R¹⁰ die oben genannte Bedeutung haben, nicht jedoch Hydroxy oder Acyloxy sind, umsetzt und das erhaltene Produkt der allgemeinen Formel VIIin which R ⁷ , R ⁸ , R ⁹ and R ^{10 have} the abovementioned meaning, but are not hydroxy or acyloxy, and the resulting product of the general formula VII

(VII)(VII)

3535

297 W297 W

gegebenenfalls am Indolstickstoff mit einem Alkylierungsmittel R^x-X, wobei R¹ mit Ausnahme von Wasserstoff die oben genannten Bedeutungen hat,, nicht jedoch funkt:'onel Ie Gruppen enthält, die die nachfolgenden Umsetzungen stören würden, und X für eine leicht austretende Gruppe wie Chlor oder Brom steht, alkyliert, wobei ein Produkt der allgemeinen Formel VIIIoptionally on the indole nitrogen with an alkylating agent R ^x -X, where R ¹ , except hydrogen, has the abovementioned meanings but does not have the following: ## STR1 ## contains groups which would interfere with the subsequent reactions, and X is a readily leaving group, such as Chloro or bromo, alkylated, whereby a product of the general formula VIII

(VIII)(VIII)

erhalten wird, bei der R¹ verschieden von Wasserstoff und R² gleich Wasserstoff und R⁷ bis R¹⁰ eine der oben genannten Bedeutungen besitzen, nicht jedoch für Hydroxy oder Acyloxy stehen.is obtained, in which R ^{1 is} different from hydrogen and R ² is hydrogen and R ⁷ to R ^{10 have} one of the meanings mentioned above, but are not hydroxy or acyloxy.

2. Verfahren nach Anspruch 1, dadurch gekennzeichnet, daß man 3is-(lH-indol-3-yl)maleinimide der allgemeinen Formel I gemäß Anspruch 1, in denen R¹ und/oder R² Wasserstoff, Methyl-, Ethyl-, n-Propyl-, Isopropyl-, η-Butyl-, Benzyl-, Acetyl-, Methoxycarbonylmethyl-, 2-Methoxyethyl-, 2-Aminoethyl-, 3-Aminopropyl-, l-Amino-2-propyl-, 2-Dimethylarainoethyl-, 3-Dimethylamino-l-propyl-, 3-Dimethylamino-2-propyl-, 2-Diethylaminoethyl-, 2-(N-Benzyl-N-methylamino)ethyl-, 3-(N-Benzyl-N-methylamino)propyl-, 3-Dimethylamino-2-hydroxy-l-propyl-, 2-Piperidinoethyl-, 3-Piperidinopropyl-, 2-Pyrrolidinoethyl-, 3-Pyrrolidinopropyl, 2-Morpholinoethyl-, 3-Morpholinopropyl-, Pyrrolidin-2-y!methyl-, N-Methyl-pyrrolidin-2-y!methyl-,2. The method according to claim 1, characterized in that 3is (lH-indol-3-yl) maleimides of the general formula I according to claim 1, in which R ¹ and / or R ^{2 is} hydrogen, methyl, ethyl, n Propyl, isopropyl, η-butyl, benzyl, acetyl, methoxycarbonylmethyl, 2-methoxyethyl, 2-aminoethyl, 3-aminopropyl, 1-amino-2-propyl, 2-dimethylarainoethyl, 3-Dimethylamino-1-propyl, 3-dimethylamino-2-propyl, 2-diethylaminoethyl, 2- (N-benzyl-N-methylamino) ethyl, 3- (N-benzyl-N-methylamino) propyl , 3-Dimethylamino-2-hydroxy-1-propyl, 2-piperidinoethyl, 3-piperidinopropyl, 2-pyrrolidinoethyl, 3-pyrrolidinopropyl, 2-morpholinoethyl, 3-morpholinopropyl, pyrrolidin-2-ylmethyl N, N-methylpyrrolidin-2-ylmethyl,

Glucosyl-, Rhamnosyl-, Ribosyl-, Deoxyribosyl-, Aminoglycosyl-, 3-Hydroxypropyl-, 2-Carboxyethyl-, 2-Dimethylaminoethylcarbonyl-, Dimethylaminomethylcarbonyl-·, 2-Hydroxyethoxymethyl-, (2-Hydroxy-l-hydroxymethyl) ethoxymethyl- oder (3-Hydroxy-l-hydroxymethyl)propoxymethylgruppen bedeuten und R³ und/oder R Wasserstoff, Chlor, Brom, Fluor oder Trifluormethyl-, Methyl-, Ethyl-, Hydroxy-, Benzyloxy-, Methoxy-, Amino-, Dimethylamino-, 2-Aminoethoxy-, 3-Aminopropoxy-, l-Amino-2-propoxy-, 2-Dimethylaminoethoxy-, 3-Dimethylamino-l-propoxy, 3-Glucosyl, rhamnosyl, ribosyl, deoxyribosyl, aminoglycosyl, 3-hydroxypropyl, 2-carboxyethyl, 2-dimethylaminoethylcarbonyl, dimethylaminomethylcarbonyl, 2-hydroxyethoxymethyl, (2-hydroxy-1-hydroxymethyl) ethoxymethyl or (3-hydroxy-1-hydroxymethyl) propoxymethyl groups and R ³ and / or R are hydrogen, chlorine, bromine, fluorine or trifluoromethyl, methyl, ethyl, hydroxy, benzyloxy, methoxy, amino, dimethylamino , 2-aminoethoxy, 3-aminopropoxy, 1-amino-2-propoxy, 2-dimethylaminoethoxy, 3-dimethylamino-1-propoxy, 3

Dimethylamino-2-propoxy-, 2-Diethylaminoethoxy-, 2-[N-Benzyl-N-methylamino]ethoxy-, 3-[N-Benzyl-N-methylamino]propoxy-, 3-Dimethylamino-2-hydroxy-1-propoxy-, 2-Piperidinoethoxy-, 3-Piper.idinopropoxy-, 2-Pyrrolidinoethoxy-, 3-Pyrrolidinopropoxy-, 2-Morpholinoethoxy-, 3-Morpholinopropoxy-, Pyrrolidin-2-ylmethoxy-, 2-Piperazinoethoxy-, 3-Piperazinopropoxy- oder N-Methyl-pyrrolidin-2-ylmethoxygruppen oder R⁴ und R⁵ und/oder R⁸ und R⁹ zusammen eine Methylendioxygruppe 2Q darstellen,Dimethylamino-2-propoxy, 2-diethylaminoethoxy, 2- [N-benzyl-N-methylamino] ethoxy, 3- [N-benzyl-N-methylamino] propoxy, 3-dimethylamino-2-hydroxy-1- propoxy, 2-piperidinoethoxy, 3-piperidinyl, 2-pyrrolidinoethoxy, 3-pyrrolidinopropoxy, 2- morpholinoethoxy, 3-morpholinopropoxy, pyrrolidin-2-ylmethoxy, 2-piperazinoethoxy, 3-piperazinopropoxy or N-methylpyrrolidin-2-ylmethoxy groups or R ⁴ and R ⁵ and / or R ⁸ and R ⁹ together represent a methylenedioxy group 2Q,

herstellt.manufactures.

3. Verfahren nach Anspruch 1, dadurch gekennzeichnet, daß man Bis-(lH-indol-3-yl)maieinimid der 1 2
Formel I, in welcher R und R gleich oder verschieden sind und Wasserstoff, eine geradkettige cder verzweigte Alkylgruppe mit 1 bis 4 C-Atomen, eine Aminoalkylgruppe mit 1 bis 4 C-Atomen in der Alkylgruppe, die an der Alkylgruppe durch Alkoxygruppen mit 1 bis 4 C-Atomen substituiert sein kann, und die am Stickstoffatom unsubstituiert oder mono- oder disubstituiert durch Alkylreste mit 1 bis 4 C-Atomen sein kann, bedeuten, R³, R⁶, R⁷ und R¹⁰ Wasserstoff bedeuten und R⁴, R⁵, R⁸ und R⁹ 3. The method according to claim 1, characterized in that bis (lH-indol-3-yl) maieinimid of 1 2
Formula I in which R and R are the same or different and are hydrogen, a geradkettige or the branched alkyl group having 1 to 4 carbon atoms, an aminoalkyl group having 1 to 4 carbon atoms in the alkyl group, on the alkyl group by alkoxy groups with 1 to 4 C atoms may be substituted, and which may be unsubstituted or mono- or disubstituted by alkyl radicals having 1 to 4 carbon atoms on the nitrogen atom, R ³ , R ⁶ , R ⁷ and R ^{10 is} hydrogen and R ⁴ , R ⁵ , R ⁸ and R ⁹

2,332.33

^ unabhängig voneinander Wasserstoff, C_1-4-AIlCyI, C_1-4-AIkOXy₁ Halogen, eine Aminogruppe, eine Dimethylaminogruppe, eine Nitrogruppe, eine Trifluonnethylgruppe, eine Benzyloxygruppe, eine Hydroxygruppe, eine Aminoalkoxygruppe mit 1 bis 4 C-Atoinen in der Alkylgruppe, die an der ' Alkylgruppe durch Alkoxygruppen mit 1 bis 4 C-Atomen substituiert sein kann, und die am Stickstoffatom unsubstituiert oder mono- oder disubstituiert durch Alkylreste mit 1 bis 4 C-Atomen sein kann, bedeuten oder zwei benachbarte Reste R⁴, R⁵, R⁸ und R⁹ bedeuten zusammen eine Methylendioxygruppe, ^ Are independently hydrogen, C _1-4 -alkyl, C _1-4 -alkoxy _{1 is} halogen, an amino group, a dimethylamino group, a nitro group, a Trifluonnethylgruppe, a benzyloxy group, a hydroxy group, an aminoalkoxy group having 1 to 4 C-Atoinen in the Alkyl group which may be substituted on the 'alkyl group by alkoxy groups having 1 to 4 carbon atoms, and which may be unsubstituted or mono- or disubstituted on the nitrogen atom by alkyl radicals having 1 to 4 carbon atoms, or two adjacent radicals R ⁴ , R ⁵ , R ⁸ and R ⁹ together represent a methylenedioxy group,

herstellt.manufactures.

4. Verfahren nach Anspruch 1, dadurch gekennzeichnet, daß man als Bis-(lH-indol-3-yl)maleinimid-Derivate4. The method according to claim 1, characterized in that as bis (lH-indol-3-yl) maleimide derivatives

2-(lH-Indol-3-yl)-3-(l-methyl-lH-indol-3-yl)-maleinimid ,2- (1H-indol-3-yl) -3- (1-methyl-1H-indol-3-yl) -maleimide,

2,3-Bis-(l-methyl-lH-indol-3-yl)maleinimid2,3-bis (l-methyl-lH-indol-3-yl) maleimide

2-;iH-Indol-3-yl)-3-[l-(3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid 2-; iH-indol-3-yl) -3- [l- (3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide

2-(5-Benzyloxy-lH-indol-3-yl)-3-(lH-indol-3-yl)maleinimid2- (5-benzyloxy-lH-indol-3-yl) -3- (lH-indol-3-yl) maleimide

2,3-Bis(5-metrioxy-lH-indol-3-yl)maleinimid2,3-bis (5-metrioxy-lH-indol-3-yl) maleimide

2-(lH-Indol-3-yl)-3-(5,6-methylendioxy-lH-indol-3-yl)maleinimid 2- (lH-indol-3-yl) -3- (5,6-methylenedioxy-lH-indol-3-yl) maleimide

2 ,3-Bis--(5, 6-methylendioxy"lH-indcl-3-yl)maleinimid2, 3-bis- (5,6-methylenedioxy "1H-indcl-3-yl) maleimide

2--(lH-Indol-3-yl) -3-(5-methoxy-lH-inaol-:>-yl)maleinimid2 - (1H-Indol-3-yl) -3- (5-methoxy-1H-inaol -:> - yl) maleimide

2- (5-Benzyloxy-lH-indol-3-yl) -3·- [ 1- (3-diinethylaminopropyl) lH-indol-3-yl]maleinimid2- (5-Benzyloxy-1H-indol-3-yl) -3 · - [1- (3-dimethylaminopropyl) -1H-indol-3-yl] maleimide

2-[5-Benzyloxy-l-(3-dimethylaminopropyl)-lH-indol-3-yl]-3-.. (lH-indol-3-yl)maleinimid2- [5-Benzyloxy-1- (3-dimethylaminopropyl) -1H-indol-3-yl] -3- .. (1H-indol-3-yl) maleimide

2-(5-Methoxy-lH-indol-3-yl)-3-[5-methoxy-l-rjdimethylaminopropyl)-lH-indoi-3-yl]maleinimid 2- (5-methoxy-lH-indol-3-yl) -3- [5-methoxy-l-rjdimethylaminopropyl) -lH-indol-3-yl] -maleimide

_2G (±)-2-(lH-Indol-3-yl)-3-[l-(3-dimethylamino-2-methoxypropyl)-lH-indol-3-yl]maleinimid _2G (±) -2- (1H-indol-3-yl) -3- [1- (3-dimethylamino-2-methoxypropyl) -1H-indol-3-yl] maleimide

2-(lH-Indol-3-yl)-3-[5-(3-dimethylaminopropyloxy)-lH-indol 3-yl]maieinimid2- (1H-Indol-3-yl) -3- [5- (3-dimethylaminopropyloxy) -1H-indol-3-yl] -maleimide

2,3-Bis-(5-fluor-lH"indol-3-yl)maleinimid2,3-bis (5-fluoro-lH 'indol-3-yl) maleimide

2-(5-Fluor-lH-indol-3-yl)-3-[5-fluor-l-(3-dimethylaminopropyl)-lH-indoi-3-yl]maleinimid 2- (5-fluoro-lH-indol-3-yl) -3- [5-fluoro-l- (3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide

2,3-Bis-(5-ben2yloxy-lH-indol-3-yl)maleinimid2,3-bis- (5-ben2yloxy-lH-indol-3-yl) maleimide

2-(5-Benzyloxy-lH-indol-3-yl)-3-[5-benzyloxy-l-(3-di\aethylaminopropyl-lH-indol-3-yl j maleinimid2- (5-Benzyloxy-1H-indol-3-yl) -3- [5-benzyloxy-1- (3-dimethylaminopropyl-1H-indol-3-yl] maleimide

2-[ 5-Benzyloxy-l- (3-dimethylaminopropyl) -lH-indol-3-yl ] -;· ·- (l-methyl-lH-indol-3-yl)maleinimid2- [5-Benzyloxy-1- (3-dimethylaminopropyl) -1H-indol-3-yl] -; - - - (1-methyl-1H-indol-3-yl) maleimide

2,3-Bis-(5-chlor-lH-indol-3-yl)maleinimid2,3-bis (5-chloro-lH-indol-3-yl) maleimide

2-(5-Chlor-lH-indol-3-yl)-3-[5-chlor-l-(3-dimethylaminopropy1)-lH-indol-3-yl]maleinimid 2- (5-chloro-lH-indol-3-yl) -3- [5-chloro-l- (3-dimethylaminopropy1) -lH-indol-3-yl] -maleimide

2,3-Bis-(5-methyl-lH-indol-3-yl)maleinimid2,3-bis (5-methyl-lH-indol-3-yl) maleimide

2-(5-MC!thyl-lH-indol-3-yl)-3-[5~methyl-l-(3-dimethylaminopropyl)-lH-indol-3-yl]maleinimid 2- (5-MC! Thyl-lH-indol-3-yl) -3- [5 ~ methyl-l- (3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide

2, 3-Bis-(5-brom-lH-indol-3-yl)maleinimid2, 3-bis (5-bromo-1H-indol-3-yl) maleimide

2-(5-Brom-lH-indol-3-yl)-3-[5-brom-l-(3-dimethylaminopropy1)-lH-indol-3-yl]maleinimid 2- (5-bromo-lH-indol-3-yl) -3- [5-bromo-l- (3-dimethylaminopropy1) -lH-indol-3-yl] -maleimide

2-(lH-Indol-3-yl)-3-[l-(2-dimethylaminoethyl)-lH-indol-3-yl]-maleinimid; 2- (lH-indol-3-yl) -3- [l- (2-dimethylaminoethyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-yl)-3-[l-(3-(l-piperidino)propyl)-lH-indol-3-yl]-maieinimid; 2- (lH-indol-3-yl) -3- [l- (3- (l-piperidino) propyl) -lH-indol-3-yl] -maieinimid;

2-(lH-Indol-3-yl)-3-[l-(3-(4-morpholino)propyl)-lH-indol-3· yl]-maleinimid;2- (1H-indol-3-yl) -3- [1- (3- (4-morpholino) propyl) -1H-indol-3-yl] -maleimide;

2-[i-(3-Diethylaminopropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid; 2- [i- (3-diethylaminopropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(±)-2-[l-(3-Diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3· (lH-indol-3-yl)-maleinimid;(±) -2- [1- (3-diethylamino-2-hydroxypropyl) -1H-indol-3-yl] -3 · (1H-indol-3-yl) -maleimide;

(+)-2-[l-(3-Diethylaminc-2-hydroxypropyl)-lH-indol-3-yl]-3· (lH-indol-3-yl)-maleinimid;(+) - 2- [1- (3-diethylamine-2-hydroxypropyl) -1H-indol-3-yl] -3 · (1H-indol-3-yl) -maleimide;

(-)-2-[l-(3-Diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-· (lH-indol-3-yl)-maleinimid;(-) - 2- [1- (3-Diethylamino-2-hydroxypropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-(5-Methoxy-lH-indol-3-yl)-3-[l-(3-dimethylaminopropyl)-lH-indol-3-yl]-maleinimid; 2- (5-methoxy-lH-indol-3-yl) -3- [l- (3-dimethylaminopropyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3:-yl) -3-[5-methoxy-l-(3-dimethylaminopropyl) -IH-indol-3-yl]-maleinimid; 2- (1H-indol-3: -yl) -3- [5-methoxy-1- (3-dimethylaminopropyl) -IH-indol-3-yl] -maleimide;

(±)-2-[l-(::,3-Dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl) -malei.nimid;(±) -2- [l - (::, 3-dihydroxypropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[1-(2,3-Dihydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid; (+) -2- [1- (2,3-dihydroxypropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(-)-2-[l-(2,3-Dihydroxypropyl)-lH-indol-3-yl]-3-(lK-indol-3-yl)-maleinimid; (-) -2- [1- (2,3-Dihydroxypropyl) -1H-indol-3-yl] -3- (1K-indol-3-yl) -maleimide;

2-(5-Methoxy-lH-indol-3-yl)-3-[l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-maleinimid; 2- (5-methoxy-lH-indol-3-yl) -3- [l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -maleimide;

2-(lH-Indol-3-y1)-3-[5-methoxy-l-(3-(4-morpholino)propyl)-lH-indol-3-yl]-maXeinimid; 2- (lH-indol-3-y1) -3- [5-methoxy-l- (3- (4-morpholino) propyl) -lH-indol-3-yl] -maXeinimid;

(±)-2-[l-(3-Ethoxy-2-hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid; (±) -2- [l- (3-ethoxy-2-hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(+)-2-[l-(3-Ethoxy-2"hydroxypropyl)-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid; (+) - 2- [l- (3-ethoxy-2 "hydroxypropyl) -lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(-) -2-[l-(3-Ethoxy-2-hydroxypropyl) -lH-indol-3-yl]-3-(i:;iindol-3-yl)-maleinimid; (-) -2- [1- (3-ethoxy-2-hydroxypropyl) -1H-indol-3-yl] -3- (i: i-indol-3-yl) -maleimide;

(±)-2-[l-(2-Hydroxy-3-(l-piperidino)-propyl)-lH-indol-3-yl]· 3-(lH-indol-3-yl)-maleinimid;(±) -2- [1- (2-hydroxy-3- (1-piperidino) -propyl) -1H-indol-3-yl] .3- (1H-indol-3-yl) -maleimide;

( + ) -2-[l-(2-Hydroxy-3-(l-pipei.-idino) -propyl) -lH-indol-3-yl] 3-(lH-indol-3-yl)-maleinimid;(+) -2- [1- (2-hydroxy-3- (1-piperidino) -propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(-) -2-[l-(2-Hydroxy-3-(l-piperidino)-propyl)-lH-indol-3-yl] 3-(lH-indol-3-yl)-maleinimid;(-) -2- [1- (2-Hydroxy-3- (1-piperidino) -propyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±) -2-[1-(3-Diethylamino-2-hydroxypropy1)-5-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid; (±) -2- [1- (3-diethylamino-2-hydroxypropyl) -5-methoxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(+)-2-[1-(3-Diethylamino-2-hydroxypropyl)-5-methoxy-lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid; (+) - 2- [1- (3-diethylamino-2-hydroxypropyl) -5-methoxy-lH-indol-3-yl] -3- (lH-indol-3-yl) maleimide;

(") -2-[.L-(3-Diethylamino-2-hydroxypropyl) -5-methoxy-lH-indoi.-3-yl]-3-(lH-indol-3-yl)-maleinimid; (") -2 - [. L- (3-diethylamino-2-hydroxypropyl) -5-methoxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

(±) -2-[l-(3-Diethylaiaino-2-hydroxypropyl) -lH-indol-3-yl]-3 Iu (5-methoxy-lH-indol-3-yl)-maleinimid;(±) -2- [1- (3-diethylaiaino-2-hydroxypropyl) -1H-indol-3-yl] -3 Iu (5-methoxy-1H-indol-3-yl) -maleimide;

-2-[l-(3-Diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(5-methoxy-lH-indol-3-yl)-maleinimid; -2- [l- (3-diethylamino-2-hydroxypropyl) -lH-indol-3-yl] -3- (5-methoxy-lH-indol-3-yl) maleimide;

(-) -2-[l-(3-Diethylamino-2-hydroxypropyl)-lH-indol-3-yl]-3-(5-methoxy-lH-indol-3-yl)-maleinimid; (-) -2 - [1- (3-diethylamino-2-hydroxypropyl) -1H-indol-3-yl] -3- (5-methoxy-1H-indol-3-yl) -maleimide;

2-(lH-Indol-3-yl)-3-[5-methoxy-l-(3-(1-piperidino)propyl)-IH-indol-3-yl]-maleinimid; 2- (lH-indol-3-yl) -3- [5-methoxy-l- (3- (1-piperidino) propyl) -IH-indol-3-yl] -maleimide;

2-(5-Methoxy-lH-indol-3-yl)-3-[l-(3-(l-piperidino)propyl)-lH-indol-3-yl]-maleinimid; 2- (5-methoxy-lH-indol-3-yl) -3- [l- (3- (l-piperidino) propyl) -lH-indol-3-yl] -maleimide;

2- [ 1-(3-Diethylaminopropyl)-5-methoxy-lH-indol-3-yl]-3-(5,6-dimethoxy-l-methyl-lH-indol-3-yl) -maleinimid;2- [1- (3-diethylaminopropyl) -5-methoxy-1H-indol-3-yl] -3- (5,6-dimethoxy-1-methyl-1H-indol-3-yl) -maleimide;

2- [ 1- (3-Diethylaminopropyl) -5-methoxy-lH-indol-3-yl ] -3- (IH-indol-3-yl) -nialeinimid;2- [1- (3-diethylaminopropyl) -5-methoxy-1H-indol-3-yl] -3- (1H-indol-3-yl) -nialeinimide;

2-[l-(3-Diethylarainopropyl) -lH-indol-3-yl)-3-(5-methoxy-lH-indol-3-yl)-maleinimid; 2- [1- (3-diethylarainopropyl) -1H-indol-3-yl) -3- (5-methoxy-1H-indol-3-yl) -maleimide;

2-[1-(3-Diethylaminopropyl) -S-2- [1- (3-diethylaminopropyl) -S-

methoxy-lH"indol-3-yl)-maleinimid;methoxy-lH 'indol-3-yl) maleimide;

2-[5-Fluor-l-(3-dimethylaminopropyl) -lH-indol-3-yl]-3-(lH-indol-3-yl)-maleinimid;2- [5-fluoro-1- (3-dimethylaminopropyl) -1H-indol-3-yl] -3- (1H-indol-3-yl) -maleimide;

2-(5-Fluor-lH-indol-3-yl) -3-[l-(3-dimethylaminoplopyl) -IH-indol-3-yl]-maleinimid und2- (5-fluoro-1H-indol-3-yl) -3- [1- (3-dimethylaminoplopyl) -IH-indol-3-yl] -maleimide and

2-[l-(3-Diethylaminopropyl)-6-methoxy-lH-indol-3-yl]-3-(5-methoxy-lH-indol-3-yl)-maleinimid herstellt.2- [1- (3-diethylaminopropyl) -6-methoxy-1H-indol-3-yl] -3- (5-methoxy-1H-indol-3-yl) -maleimide.

5. Verwendung von Verbindungen der allgemeinen Formel I, dadurch gekennzeichnet, daß sie zur Herstellung von Arzneimitteln zur Prävention oder Behandlung von Herz- und Gefäßkrankheiten wie Thrombosen, Arteriosklerose, Hypertension, von Enr.zürdungsprozessen, Allergien, Krebs und bestimmten degenerativen Schaden des Zentralnervensystems sowie von Krankheiten des Immunsystems und viralen Erkrankungen eingesebzt werden.5. Use of compounds of the general formula I, characterized in that they are used for the production of medicaments for the prevention or treatment of cardiovascular diseases such as thrombosis, arteriosclerosis, hypertension, Enzermdungsprozessen, allergies, cancer and certain degenerative damage of the central nervous system and of diseases of the immune system and viral diseases.