DD213215A5 - Verfahren zur herstellung von n'phenyl-n'-cycloalkylalkanoyl-piperazinen - Google Patents

Verfahren zur herstellung von n'phenyl-n'-cycloalkylalkanoyl-piperazinen Download PDF

Info

Publication number
DD213215A5
DD213215A5 DD84261152A DD26115284A DD213215A5 DD 213215 A5 DD213215 A5 DD 213215A5 DD 84261152 A DD84261152 A DD 84261152A DD 26115284 A DD26115284 A DD 26115284A DD 213215 A5 DD213215 A5 DD 213215A5
Authority
DD
German Democratic Republic
Prior art keywords
radical
groups
group
phenyl
alk
Prior art date
Application number
DD84261152A
Other languages
German (de)
English (en)
Inventor
Gerhard Oepen
Juergen Engel
Vladimir Jakovlev
Klaus Thiemer
Original Assignee
Degussa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa filed Critical Degussa
Publication of DD213215A5 publication Critical patent/DD213215A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DD84261152A 1983-03-25 1984-03-22 Verfahren zur herstellung von n'phenyl-n'-cycloalkylalkanoyl-piperazinen DD213215A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3310871 1983-03-25

Publications (1)

Publication Number Publication Date
DD213215A5 true DD213215A5 (de) 1984-09-05

Family

ID=6194617

Family Applications (1)

Application Number Title Priority Date Filing Date
DD84261152A DD213215A5 (de) 1983-03-25 1984-03-22 Verfahren zur herstellung von n'phenyl-n'-cycloalkylalkanoyl-piperazinen

Country Status (17)

Country Link
US (1) US4547505A (fr)
EP (1) EP0120465B1 (fr)
JP (1) JPS59205362A (fr)
AT (1) ATE20887T1 (fr)
AU (1) AU560579B2 (fr)
CA (1) CA1211435A (fr)
DD (1) DD213215A5 (fr)
DE (1) DE3460325D1 (fr)
DK (1) DK142084A (fr)
ES (2) ES530902A0 (fr)
FI (1) FI841181A (fr)
HU (1) HU191643B (fr)
IL (1) IL71324A (fr)
NO (1) NO841163L (fr)
PT (1) PT78304B (fr)
SU (1) SU1297727A3 (fr)
ZA (1) ZA842185B (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2536071B1 (fr) * 1982-11-12 1986-07-11 Sanofi Sa Sels acides de 2-piperazinopyrimidine, procede pour leur preparation et compositions pharmaceutiques en contenant
EP0582065A1 (fr) * 1986-08-15 1994-02-09 WHITBY RESEARCH, Inc. Compositions de azacyclohexanes substitués par 1-oxohydrocarbyl comme catalyseur acide
US4797405A (en) * 1987-10-26 1989-01-10 Eli Lilly And Company Stabilized pergolide compositions
EP0370560B1 (fr) * 1988-11-24 1994-01-12 Akzo Nobel N.V. Compositions pharmaceutiques contenant des 1-[mono ou bis(trifluorométhyl)-2-pyridinyl]pipérazines
EP0385043A1 (fr) * 1989-02-28 1990-09-05 Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. (Faes) Dérivés de pipérazinessubstituées en 4
US5648352A (en) * 1991-09-13 1997-07-15 Merck & Co., Inc. Piperazinylcamphorsulfonyl oxytocin antagonists
EP0533240A3 (en) * 1991-09-16 1993-09-29 Merck & Co. Inc. Substituted amine derivatives of piperazinylcamphorsulfonyl oxytocin antagonists
EP0533242A3 (en) * 1991-09-16 1993-09-15 Merck & Co. Inc. Substituted derivatives of piperazinylcamphorsulfonyl oxytocin antagonists
EP0533241A3 (en) * 1991-09-16 1993-09-29 Merck & Co. Inc. Substituted alkyl derivatives of piperazinylcamphorsulfonyl oxytocin antagonists
JPH05255089A (ja) * 1991-12-18 1993-10-05 Sanwa Kagaku Kenkyusho Co Ltd 抗ウイルス剤
HU209678B (en) * 1992-06-09 1994-10-28 Richter Gedeon Vegyeszet Process for producing biologically active eburnamenin-14-carbonyl-amino derivatives and pharmaceutical compositions containing them
EP0708765A4 (fr) * 1993-07-16 1996-06-26 Merck & Co Inc Derives de piperazinylcamphre substitues en tant qu'antagonistes de l'ocytocine
ES2125206B1 (es) * 1997-07-21 1999-11-16 Esteve Labor Dr Derivados de acil-piperazinil-pirimidinas, su preparacion y su aplicacion como medicamentos.
ES2167276B1 (es) * 2000-10-20 2003-04-01 Esteve Labor Dr Nuevos derivados de cianoaril (o cianoheteroaril)-carbonil-piperazinil-pirimidinas, su preparacion y su aplicacion como medicamentos.
US7589199B2 (en) 2002-06-12 2009-09-15 Chemocentryx, Inc. Substituted piperazines
US20050256130A1 (en) * 2002-06-12 2005-11-17 Chemocentryx, Inc. Substituted piperazines
KR101255356B1 (ko) 2002-06-12 2013-04-17 케모센트릭스, 인크. 염증 및 면역 질병의 치료를 위한 ｃｃｒ１ 길항물질로서사용하기 위한 1-아릴-4-치환된 피페라진 유도체
US7842693B2 (en) * 2002-06-12 2010-11-30 Chemocentryx, Inc. Substituted piperazines
US8013156B2 (en) * 2003-03-19 2011-09-06 Exelixis, Inc. Tie-2 modulators and methods of use
JP4845873B2 (ja) * 2004-03-03 2011-12-28 ケモセントリックス インコーポレーティッド 二環式および架橋した窒素複素環
US7435831B2 (en) * 2004-03-03 2008-10-14 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
US8389510B2 (en) * 2005-11-18 2013-03-05 Astrazeneca Ab Crystalline forms
CN101616585A (zh) * 2006-12-20 2009-12-30 阿斯利康(瑞典)有限公司 化合物及其用途
PL2195293T3 (pl) * 2007-08-22 2014-03-31 Astrazeneca Ab Pochodne cyklopropyloamidu
TW201039825A (en) * 2009-02-20 2010-11-16 Astrazeneca Ab Cyclopropyl amide derivatives 983
NZ602110A (en) 2010-02-18 2014-09-26 Astrazeneca Ab Processes for making cyclopropyl amide derivatives and intermediates associated therewith
KR20130034009A (ko) * 2010-02-18 2013-04-04 아스트라제네카 아베 시클로프로필 아미드 유도체를 포함하는 고체 형태
FR3000065A1 (fr) 2012-12-21 2014-06-27 Univ Lille Ii Droit & Sante Composes bicycliques ayant une activite potentialisatrice de l'activite d'un antibiotique actif contre les mycobacteries-composition et produit pharmaceutiques comprenant de tels composes
CN115368318B (zh) * 2022-06-22 2023-11-03 山东辰龙药业有限公司 一种伏硫西汀的合成方法及应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK143899C (da) * 1975-04-21 1982-04-13 Merck & Co Inc Analogifremgangsmaade til fremstilling af piperazinylpyrazinderivater
JPS52286A (en) * 1975-05-27 1977-01-05 Kyorin Pharmaceut Co Ltd Method of preparing 1-(3-phenylpropyl)-4-acylpiperazine derivatives
GB1534593A (en) * 1976-09-03 1978-12-06 Soc D Etudes Prod Chimique N-2,6-dichlorophenyl-2-aminopyrimidine and therapeutic compositions containing it
AU546260B2 (en) * 1980-06-16 1985-08-22 Ferrosan A.B. Diphenylbutyl-1-acylpiperazines
US4666911A (en) * 1981-07-14 1987-05-19 Taiho Pharmaceutical Company Limited Allophanoylpiperazine compound and analgesic composition containing same as active ingredient
JPS591474A (ja) * 1982-06-07 1984-01-06 Nippon Iyakuhin Kogyo Kk ピペラジン環を有するゲラニルゲラニル酢酸アミド化合物またはその塩類

Also Published As

Publication number Publication date
FI841181A (fi) 1984-09-26
HU191643B (en) 1987-03-30
EP0120465B1 (fr) 1986-07-23
DE3460325D1 (en) 1986-08-28
SU1297727A3 (ru) 1987-03-15
ES530901A0 (es) 1984-11-16
NO841163L (no) 1984-09-26
DK142084A (da) 1984-09-26
ZA842185B (en) 1984-10-31
IL71324A (en) 1987-08-31
IL71324A0 (en) 1984-06-29
US4547505A (en) 1985-10-15
PT78304A (de) 1984-04-01
AU560579B2 (en) 1987-04-09
CA1211435A (fr) 1986-09-16
DK142084D0 (da) 1984-02-29
FI841181A0 (fi) 1984-03-23
JPS59205362A (ja) 1984-11-20
ES8501384A1 (es) 1984-11-16
AU2605784A (en) 1984-09-27
EP0120465A1 (fr) 1984-10-03
ES530902A0 (es) 1984-11-16
PT78304B (de) 1986-04-22
ATE20887T1 (de) 1986-08-15
ES8501383A1 (es) 1984-11-16

Similar Documents

Publication Publication Date Title
DD213215A5 (de) Verfahren zur herstellung von n'phenyl-n'-cycloalkylalkanoyl-piperazinen
EP0554543B1 (fr) Dérivés de 1,2,4-triaminobenzène et procédé de leur préparation
DE2634288A1 (de) Benzylidenderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
CH624413A5 (fr)
DE2611690A1 (de) Cyclische sulfonyloxyimide
DE3931432A1 (de) Pyrimidin-4,6-dicarbonsaeurediamide, verfahren zu deren herstellung sowie verwendung derselben sowie arzneimittel auf basis dieser verbindungen
WO1998011062A1 (fr) Derives de benzamidine et leur utilisation comme medicaments ayant un effet antagoniste vis-a-vis de ltb4
DE2508045A1 (de) Substituierte n-(1-benzylpyrrolidinyl-2-alkyl)-benzamide, verfahren zu deren herstellung und diese enthaltende arzneimittel
EP0165422B1 (fr) Bis-(4-aminophényl)-sulfones substituées, leur préparation et leur utilisation comme médicaments
DE1942405A1 (de) Arylsubstituierte Piperazinylalkylaminouracile bzw. -uracilaether
DE2305092A1 (de) Alpha-aminomethylbenzylalkoholderivate
DE2505297A1 (de) Neue 2-arylamino-2-imidazolinderivate und ein verfahren zu deren herstellung
DE3209276A1 (de) Arzneimittel mit antihypoxischer und ischaemie-protektiver wirkung
DE1620450B2 (de) 1-(2-Hydroxybenzyl)-2-piperazinomethylbenzimidazole, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
CH635092A5 (de) Verfahren zur herstellung neuer benzopyranderivate.
EP0064685A1 (fr) Dibenzo(de,g)quinolines, leurs procédés de préparation et les médicaments les contenant
DE2730200C2 (de) Verfahren zur Herstellung von Hydrochloriden O-acylierter Adrenalin-Derivate
DE3642497A1 (de) Substituierte aminopropionsaeureamide, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung sowie die bei der herstellung anfallenden neuen zwischenprodukte
WO1999054298A1 (fr) Procede de production de n-methyl-n-((1s)-1-phenyl-2-((3s)-3-hydroxypyrrolidin-1-yl)ethyl)-2,2-diphenylacetamide sans enantiomeres
DE1795653A1 (de) Verfahren zur herstellung von 2alkoxy-4.5-azimidobenzamiden
EP0212551B1 (fr) Composés tétraoxo
EP0234516A1 (fr) Dérivés de la 1,6-naphtyridine, procédé pour leur préparation et médicament les contenant pour le traitement des maladies cardio-vasculaires
EP0004529A2 (fr) Dérivés d'arylaminoimidazoline tantomères, procédé pour leur préparation et leur application comme analgésique dans des formulations pharmaceutiques
DE2653251A1 (de) Azabicyclo eckige klammer auf 3.1.o eckige klammer zu hexan-derivate, ihre herstellung und verwendung
DE1645974A1 (de) Isonicotinsaeureamide enthaltende Arzneimittel