CZ20011813A3 - Deriváty N-triazolylmethylpiperazinu jako antagonistické látky neurokininových receptorů, jejich výroba a léčiva - Google Patents

Deriváty N-triazolylmethylpiperazinu jako antagonistické látky neurokininových receptorů, jejich výroba a léčiva

Info

Publication number
CZ20011813A3
CZ20011813A3 CZ20011813A CZ20011813A CZ20011813A3 CZ 20011813 A3 CZ20011813 A3 CZ 20011813A3 CZ 20011813 A CZ20011813 A CZ 20011813A CZ 20011813 A CZ20011813 A CZ 20011813A CZ 20011813 A3 CZ20011813 A3 CZ 20011813A3
Authority
CZ
Czechia
Prior art keywords
triazolylmethylpiperazine
functioning
derivatives
preparation
medicaments based
Prior art date
Application number
CZ20011813A
Other languages
English (en)
Other versions
CZ301695B6 (cs
Inventor
Daniel Jasserand
Uwe Schön
Holger Sann
Reinhard Brückner
Christian Eeckhout
Original Assignee
Solvay Pharmaceuticals Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharmaceuticals Gmbh filed Critical Solvay Pharmaceuticals Gmbh
Publication of CZ20011813A3 publication Critical patent/CZ20011813A3/cs
Publication of CZ301695B6 publication Critical patent/CZ301695B6/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
CZ20011813A 2000-07-28 2001-05-23 Deriváty N-triazolylmethylpiperazinu jako antagonistické látky neurokininových receptoru, jejich výroba a léciva CZ301695B6 (cs)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10036818A DE10036818A1 (de) 2000-07-28 2000-07-28 Neue N-Triazolylmethyl-Piperazinderivate als Neurokininrezeptor-Antagonisten

Publications (2)

Publication Number Publication Date
CZ20011813A3 true CZ20011813A3 (cs) 2002-03-13
CZ301695B6 CZ301695B6 (cs) 2010-05-26

Family

ID=7650544

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ20011813A CZ301695B6 (cs) 2000-07-28 2001-05-23 Deriváty N-triazolylmethylpiperazinu jako antagonistické látky neurokininových receptoru, jejich výroba a léciva

Country Status (28)

Country Link
US (1) US6407106B1 (cs)
EP (1) EP1176144B1 (cs)
JP (1) JP2002053577A (cs)
KR (1) KR100924405B1 (cs)
CN (1) CN1167698C (cs)
AR (1) AR028743A1 (cs)
AT (1) ATE244716T1 (cs)
AU (1) AU779318B2 (cs)
BR (1) BR0103048A (cs)
CA (1) CA2354213C (cs)
CZ (1) CZ301695B6 (cs)
DE (2) DE10036818A1 (cs)
DK (1) DK1176144T3 (cs)
DZ (1) DZ3119A1 (cs)
ES (1) ES2201007T3 (cs)
HK (1) HK1042699A1 (cs)
HU (1) HU226687B1 (cs)
IL (1) IL144299A (cs)
IN (1) IN191021B (cs)
NO (1) NO323233B1 (cs)
NZ (1) NZ513041A (cs)
PL (1) PL210436B1 (cs)
PT (1) PT1176144E (cs)
RU (1) RU2288918C2 (cs)
SK (1) SK284802B6 (cs)
TW (1) TWI304403B (cs)
UA (1) UA73728C2 (cs)
ZA (1) ZA200105737B (cs)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA77515C2 (en) 2002-04-04 2006-12-15 Diazabicyclo alkane derivatives possessing neuroldnin-nk1 receptor antagonistic activity
MXPA04010622A (es) * 2002-04-26 2005-01-25 Lilly Co Eli Derivados de triazol como antagonistas de receptor de taquicinina.
DK1501808T3 (da) * 2002-04-26 2008-10-13 Lilly Co Eli Tachykininreceptor-antagonister
WO2005000821A1 (en) * 2003-06-12 2005-01-06 Eli Lilly And Company Tachykinin receptor antagonists
US20070082905A1 (en) * 2005-05-27 2007-04-12 De Vries Michiel H Pharmaceutical compositions comprising n-triazolymethyl-piperazine compounds and methods of using same
KR100978961B1 (ko) * 2005-07-25 2010-08-30 에프. 호프만-라 로슈 아게 치환된 트라이아졸 유도체 및 뉴로키닌 3 수용체길항물질로서의 상기 화합물의 용도
PE20081229A1 (es) * 2006-12-01 2008-08-28 Merck & Co Inc Antagonistas de receptor de orexina de diazepam sustituido
EP2117538A1 (en) 2007-01-24 2009-11-18 Glaxo Group Limited Pharmaceutical compositions comprising 2-methoxy-5- (5-trifluoromethyl-tetrazol-i-yl-benzyl) - (2s-phenyl-piperidin-3s-yl-)
US20120258093A1 (en) 2009-08-20 2012-10-11 Institut National De La Sante Et De La Recherche Medicale (Inserm) Vla-4 as a biomarker for prognosis and target for therapy in duchenne muscular dystrophy
DK2729147T3 (en) 2011-07-04 2017-12-18 Irbm - Science Park S P A NK-1 RECEPTOR ANTAGONISTS FOR TREATMENT OF CORNOVA
EP3758688B1 (en) 2018-02-26 2024-03-27 Ospedale San Raffaele S.r.l. Nk-1 antagonists for use in the treatment of ocular pain
US20230134843A1 (en) 2020-03-11 2023-05-04 Ospedale San Raffaele S.R.L. Treatment of stem cell deficiency
CN115184498B (zh) * 2022-07-15 2023-02-21 山东京卫制药有限公司 N-Boc-哌嗪中有关物质哌嗪的检测方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL111730A (en) * 1993-11-29 1998-12-06 Fujisawa Pharmaceutical Co Piperazine derivatives, processes for their preparation and pharmaceutical preparations containing them
US5883098A (en) 1993-11-29 1999-03-16 Fujisawa Pharmaceutical Co., Ltd. Piperazine derivatives
JP3071829B2 (ja) * 1995-05-25 2000-07-31 藤沢薬品工業株式会社 ニューロキニン受容体拮抗剤としての１−ベンゾイル−２−（インドリル−３−アルキル）−ピペラジン誘導体
GB9513118D0 (en) * 1995-06-28 1995-08-30 Merck Sharp & Dohme Therapeutic agents
ES2175161T3 (es) * 1995-12-18 2002-11-16 Fujisawa Pharmaceutical Co Derivados de piperazina como antagonistas de taquiquinina.
KR100458346B1 (ko) * 1996-03-29 2005-06-21 듀파 인터내셔날 리서치 베 파우 피페라진및피페리딘화합물
AUPO735997A0 (en) * 1997-06-17 1997-07-10 Fujisawa Pharmaceutical Co., Ltd. Piperazine derivatives
ATE396187T1 (de) * 1997-08-27 2008-06-15 Solvay Pharm Gmbh Indolmethyl-n,n'-bisacylpiperazine als neurokininrezeptorantagonisten
DE19824865A1 (de) 1997-08-27 1999-03-04 Solvay Pharm Gmbh Neue Harnstoffderivate
ES2162731B1 (es) * 1999-06-04 2003-02-16 Faes Fabrica Espanola De Produ Nuevas arilpiperacilnilalquil-3(2h)-piridacinonas.

Also Published As

Publication number Publication date
PL348946A1 (en) 2002-02-11
ES2201007T3 (es) 2004-03-16
ZA200105737B (en) 2002-01-22
SK284802B6 (sk) 2005-11-03
DK1176144T3 (da) 2003-10-27
AU5767501A (en) 2002-01-31
RU2288918C2 (ru) 2006-12-10
KR100924405B1 (ko) 2009-10-29
IL144299A0 (en) 2002-05-23
AU779318B2 (en) 2005-01-13
DZ3119A1 (fr) 2004-09-19
IN191021B (cs) 2003-09-13
HUP0102931A3 (en) 2003-07-28
AR028743A1 (es) 2003-05-21
NZ513041A (en) 2002-12-20
PT1176144E (pt) 2003-11-28
US6407106B1 (en) 2002-06-18
UA73728C2 (en) 2005-09-15
IL144299A (en) 2004-08-31
DE10036818A1 (de) 2002-02-07
SK7572001A3 (en) 2002-02-05
HU0102931D0 (en) 2001-09-28
CZ301695B6 (cs) 2010-05-26
NO20013709D0 (no) 2001-07-27
HK1042699A1 (en) 2002-08-23
EP1176144A1 (de) 2002-01-30
CA2354213C (en) 2010-04-27
KR20020010482A (ko) 2002-02-04
NO323233B1 (no) 2007-02-05
CA2354213A1 (en) 2002-01-28
DE50100358D1 (de) 2003-08-14
US20020065276A1 (en) 2002-05-30
HUP0102931A2 (hu) 2002-11-28
TWI304403B (en) 2008-12-21
EP1176144B1 (de) 2003-07-09
HU226687B1 (en) 2009-06-29
JP2002053577A (ja) 2002-02-19
NO20013709L (no) 2002-01-29
ATE244716T1 (de) 2003-07-15
CN1167698C (zh) 2004-09-22
CN1335316A (zh) 2002-02-13
PL210436B1 (pl) 2012-01-31
BR0103048A (pt) 2002-04-02

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Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of fee

Effective date: 20120523