CY2607B2 - Συνεργιστικος συνδυασμος αναστολεων pde και αγωνιστων αδενυλικης κυκλασης ή αγωνιστων γουανυλικης κυκλασης - Google Patents
Συνεργιστικος συνδυασμος αναστολεων pde και αγωνιστων αδενυλικης κυκλασης ή αγωνιστων γουανυλικης κυκλασηςInfo
- Publication number
- CY2607B2 CY2607B2 CY0900008A CY0900008A CY2607B2 CY 2607 B2 CY2607 B2 CY 2607B2 CY 0900008 A CY0900008 A CY 0900008A CY 0900008 A CY0900008 A CY 0900008A CY 2607 B2 CY2607 B2 CY 2607B2
- Authority
- CY
- Cyprus
- Prior art keywords
- agonists
- guanylcyclyse
- adenylate cyclase
- pde inhibitors
- synergistic combination
- Prior art date
Links
- 239000000556 agonist Substances 0.000 title abstract 4
- 102000030621 adenylate cyclase Human genes 0.000 title abstract 2
- 108060000200 adenylate cyclase Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 239000011885 synergistic combination Substances 0.000 title 1
- 108010078321 Guanylate Cyclase Proteins 0.000 abstract 1
- 102000014469 Guanylate cyclase Human genes 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000002815 pulmonary hypertension Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Η εφεύρεση αφορά την συνδυασμένη εφαρμογή αναστολέων PDE και αγωνιστών αδενυλικής κυκλάσης ή αγωνιστών γουανυλικής κυκλάσης για τη θεραπεία ορισμένων καταστάσεων ασθενειών, όπως για παράδειγμα της πνευμονικής υπερτονίας.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19708049 | 1997-02-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
CY2607B2 true CY2607B2 (el) | 2010-04-28 |
Family
ID=7821764
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY0900008A CY2607B2 (el) | 1997-02-28 | 2009-06-11 | Συνεργιστικος συνδυασμος αναστολεων pde και αγωνιστων αδενυλικης κυκλασης ή αγωνιστων γουανυλικης κυκλασης |
Country Status (12)
Country | Link |
---|---|
US (1) | US6333354B1 (el) |
EP (1) | EP0975347B1 (el) |
JP (2) | JP2001513097A (el) |
AT (1) | ATE386531T1 (el) |
AU (1) | AU6823098A (el) |
CY (1) | CY2607B2 (el) |
DE (1) | DE59814173D1 (el) |
DK (1) | DK0975347T3 (el) |
ES (1) | ES2302350T3 (el) |
PT (1) | PT975347E (el) |
SI (1) | SI0975347T1 (el) |
WO (1) | WO1998037894A1 (el) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001516765A (ja) * | 1997-09-12 | 2001-10-02 | ヴォルフ ゲオルグ フォースマン | 真性糖尿病及び肥満の治療のための組成物 |
PL346271A1 (en) * | 1998-08-26 | 2002-01-28 | Smithkline Beecham Corp | Therapies for treating pulmonary diseases |
IL137429A0 (en) * | 1999-07-28 | 2001-07-24 | Pfizer Prod Inc | Methods and compsitions for treating diseases and conditions of the eye |
JP2003506394A (ja) * | 1999-08-10 | 2003-02-18 | ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システム | 視力の保持を容易にするために視神経、脈絡膜、および網膜の血流を増大させるための方法 |
MXPA02001830A (es) * | 1999-08-21 | 2002-08-12 | Byk Gulden Lomberg Chem Fab | Combinacion sinergica de inhibidores de pde y agonista de beta 2 adrenoceptor. |
TW200400821A (en) * | 1999-11-02 | 2004-01-16 | Pfizer | Pharmaceutical composition (II) useful for treating or preventing pulmonary hypertension in a patient |
BR0111440A (pt) | 2000-06-05 | 2003-06-03 | Altana Pharma Ag | Compostos eficazes como agonistas do (beta)2-adrenorreceptor bem como inibidores de pde4 |
AU2000270300A1 (en) * | 2000-09-13 | 2002-03-26 | Isis Innovation Limited | Use of phosphodiesterase inhibitors for the treatment of anorectal disorders |
DE10061137B4 (de) * | 2000-12-07 | 2016-10-06 | Takeda Gmbh | Neue pharmazeutische Zubereitung |
JP2005509621A (ja) * | 2001-10-17 | 2005-04-14 | ユニバーシティ オブ ウェールズ カレッジ オブ メディスン | ギャップ結合ならびにedhf |
WO2003051346A2 (en) * | 2001-12-17 | 2003-06-26 | Altana Pharma Ag | Use of selective pde5 inhibitors for treating partial and global respiratory failure |
US7276529B2 (en) * | 2002-03-20 | 2007-10-02 | Celgene Corporation | Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
US7893101B2 (en) | 2002-03-20 | 2011-02-22 | Celgene Corporation | Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof |
US7208516B2 (en) * | 2002-03-20 | 2007-04-24 | Celgene Corporation | Methods of the treatment of psoriatic arthritis using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
US6962940B2 (en) | 2002-03-20 | 2005-11-08 | Celgene Corporation | (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof |
WO2003087333A2 (en) * | 2002-04-12 | 2003-10-23 | Celgene Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
JP2005536189A (ja) * | 2002-04-12 | 2005-12-02 | セルジーン・コーポレーション | 血管新生のモジュレーターの同定方法、それにより見出された化合物および該化合物を使用する治療方法 |
WO2003097050A2 (en) * | 2002-05-16 | 2003-11-27 | Pharmacia Corporation | A selective inos inhibitor and a pde inhibitor in combination for the treatment of respiratory diseases |
US20040077639A1 (en) * | 2002-05-16 | 2004-04-22 | Manning Pamela T. | Methods for the treatment of respiratory diseases and conditions using a selective iNOS inhibitor |
MXPA05002146A (es) * | 2002-09-16 | 2005-05-23 | Alcon Mfg Ltd | Uso de inhibidores de pde iv para tratar la angiogenesis. |
ES2309357T3 (es) * | 2002-11-27 | 2008-12-16 | Nycomed Gmbh | Nueva combinacion sinergica que comprende roflumilast y formoterol. |
BR0316475A (pt) * | 2002-11-27 | 2005-10-11 | Altana Pharma Ag | Combinação sinergìstica que compreende roflumilast e (r,r)-formoterol |
WO2004067006A1 (en) * | 2003-01-27 | 2004-08-12 | Pharmacia Corporation | Combination of a pde iv inhibitor and a tnf-alpha antagonist |
SG168407A1 (en) | 2003-01-28 | 2011-02-28 | Ironwood Pharmaceuticals Inc | Methods and compositions for the treatment of gastrointestinal disorders |
MXPA05011225A (es) * | 2003-04-18 | 2005-12-14 | Pharmacia & Upjohn Co Llc | Politerapias. |
WO2006111495A1 (en) | 2005-04-19 | 2006-10-26 | Nycomed Gmbh | Roflumilast for the treatment of pulmonary hypertension |
EP2258358A3 (en) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
WO2007025177A2 (en) | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
EP2377530A3 (en) | 2005-10-21 | 2012-06-20 | Braincells, Inc. | Modulation of neurogenesis by PDE inhibition |
US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
EP2377531A2 (en) | 2006-05-09 | 2011-10-19 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
US7678808B2 (en) | 2006-05-09 | 2010-03-16 | Braincells, Inc. | 5 HT receptor mediated neurogenesis |
MX2009002496A (es) * | 2006-09-08 | 2009-07-10 | Braincells Inc | Combinaciones que contienen un derivado de 4-acilaminopiridina. |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
CA2718412A1 (en) * | 2008-03-24 | 2009-10-01 | Celgene Corporation | Treatment of psoriasis or psoriatic arthritis using cyclopropyl-n-{2-{(1s)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-3-oxoisoindoline-4-yl}carboxamide |
WO2010019450A2 (en) * | 2008-08-09 | 2010-02-18 | Nyles Bauer | Synergizing active compounds for treating inflammation and other conditions |
WO2018129556A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
JP5502106B2 (ja) | 2008-12-31 | 2014-05-28 | アーデリクス,インコーポレーテッド | 体液貯留または塩分過負荷と関連する障害および消化管障害の治療におけるnhe媒介性アンチポートを阻害するための組成物および方法 |
WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
US11464781B2 (en) | 2009-02-25 | 2022-10-11 | Intra-Cellular Therapies, Inc. | PDE1 inhibitors for ophthalmic disorders |
US8247436B2 (en) | 2010-03-19 | 2012-08-21 | Novartis Ag | Pyridine and pyrazine derivative for the treatment of CF |
EP2804603A1 (en) | 2012-01-10 | 2014-11-26 | President and Fellows of Harvard College | Beta-cell replication promoting compounds and methods of their use |
CA2880338A1 (en) | 2012-08-21 | 2014-02-27 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
US10376481B2 (en) | 2012-08-21 | 2019-08-13 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
CA2909169A1 (en) | 2013-04-12 | 2014-10-16 | Ardelyx, Inc. | Nhe3-binding compounds and methods for inhibiting phosphate transport |
ES2749433T3 (es) | 2014-06-23 | 2020-03-20 | Celgene Corp | Apremilast para el tratamiento de una enfermedad hepática o una anomalía de la función hepática |
CN106333953A (zh) * | 2015-07-08 | 2017-01-18 | 珠海津之敦医药科技有限公司 | 尤克那非新用途 |
WO2017168174A1 (en) | 2016-04-02 | 2017-10-05 | N4 Pharma Uk Limited | New pharmaceutical forms of sildenafil |
MX2019008171A (es) | 2017-01-09 | 2020-02-05 | Ardelyx Inc | Inhibidores del antiporte mediado por nhe. |
UA126283C2 (uk) | 2017-01-09 | 2022-09-14 | Арделікс, Інк. | Сполуки, придатні для лікування розладів шлунково-кишкового тракту |
US20220143148A1 (en) | 2019-03-14 | 2022-05-12 | The Broad Institute, Inc. | Compositions and methods for modulating cgrp signaling to regulate intestinal innate lymphoid cells |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3405181A1 (de) * | 1984-02-10 | 1985-08-22 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
JPH01153634A (ja) * | 1987-12-10 | 1989-06-15 | Kyorin Pharmaceut Co Ltd | 吸入剤 |
IT1239281B (it) * | 1989-10-27 | 1993-10-19 | Indena Spa | Composizioni per la riduzione dei depositi di grasso superfluo a base di principi attivi di origine vegetale ad attivita' agonista dell'adenilato ciclasi o/e ad attivita' antifosfodiesterasica |
EP0504112A3 (en) * | 1991-03-14 | 1993-04-21 | Ciba-Geigy Ag | Pharmaceutical aerosol formulations |
US6013827A (en) * | 1994-03-11 | 2000-01-11 | Smithkline Beecham Corporation | Compounds |
US5602110A (en) | 1994-08-31 | 1997-02-11 | Case Western Reserve University | Method and composition for treating cystic fibrosis |
-
1998
- 1998-02-24 AU AU68230/98A patent/AU6823098A/en not_active Abandoned
- 1998-02-24 US US09/367,850 patent/US6333354B1/en not_active Expired - Lifetime
- 1998-02-24 PT PT98913584T patent/PT975347E/pt unknown
- 1998-02-24 DK DK98913584T patent/DK0975347T3/da active
- 1998-02-24 AT AT98913584T patent/ATE386531T1/de active
- 1998-02-24 ES ES98913584T patent/ES2302350T3/es not_active Expired - Lifetime
- 1998-02-24 SI SI9830909T patent/SI0975347T1/sl unknown
- 1998-02-24 WO PCT/EP1998/001047 patent/WO1998037894A1/de active IP Right Grant
- 1998-02-24 JP JP53729498A patent/JP2001513097A/ja not_active Withdrawn
- 1998-02-24 DE DE59814173T patent/DE59814173D1/de not_active Expired - Lifetime
- 1998-02-24 EP EP98913584A patent/EP0975347B1/de not_active Expired - Lifetime
-
2008
- 2008-11-13 JP JP2008290751A patent/JP2009073853A/ja active Pending
-
2009
- 2009-06-11 CY CY0900008A patent/CY2607B2/el unknown
Also Published As
Publication number | Publication date |
---|---|
ATE386531T1 (de) | 2008-03-15 |
DK0975347T3 (da) | 2008-06-16 |
EP0975347B1 (de) | 2008-02-20 |
WO1998037894A1 (de) | 1998-09-03 |
JP2009073853A (ja) | 2009-04-09 |
SI0975347T1 (sl) | 2008-08-31 |
US6333354B1 (en) | 2001-12-25 |
PT975347E (pt) | 2008-05-23 |
EP0975347A1 (de) | 2000-02-02 |
DE59814173D1 (de) | 2008-04-03 |
ES2302350T3 (es) | 2008-07-01 |
AU6823098A (en) | 1998-09-18 |
JP2001513097A (ja) | 2001-08-28 |
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