CY2431B1 - Novel phenanthridines substituted in the 6 position. - Google Patents
Novel phenanthridines substituted in the 6 position.Info
- Publication number
- CY2431B1 CY2431B1 CY0400018A CY0400018A CY2431B1 CY 2431 B1 CY2431 B1 CY 2431B1 CY 0400018 A CY0400018 A CY 0400018A CY 0400018 A CY0400018 A CY 0400018A CY 2431 B1 CY2431 B1 CY 2431B1
- Authority
- CY
- Cyprus
- Prior art keywords
- novel
- substituted
- phenanthridines substituted
- novel phenanthridines
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
- C07D221/12—Phenanthridines
Abstract
Compounds of formula (I) in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings given in the description, are novel effective bronchial therapeutic agents.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19611922 | 1996-03-26 | ||
EP96105038 | 1996-03-29 | ||
DE1996113091 DE19613091A1 (en) | 1996-04-02 | 1996-04-02 | New 6-substituted phenanthridine derivatives |
EP96105311 | 1996-04-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
CY2431B1 true CY2431B1 (en) | 2004-11-12 |
Family
ID=27438318
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY0400018A CY2431B1 (en) | 1996-03-26 | 2004-03-12 | Novel phenanthridines substituted in the 6 position. |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0889886B1 (en) |
JP (1) | JP4141501B2 (en) |
AT (1) | ATE224386T1 (en) |
AU (1) | AU718752B2 (en) |
CA (1) | CA2250569C (en) |
CY (1) | CY2431B1 (en) |
DE (1) | DE59708265D1 (en) |
DK (1) | DK0889886T5 (en) |
ES (1) | ES2184077T3 (en) |
PT (1) | PT889886E (en) |
SI (1) | SI0889886T1 (en) |
WO (1) | WO1997035854A1 (en) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1000035B1 (en) * | 1997-07-25 | 2002-11-27 | ALTANA Pharma AG | Substituted 6-phenylphenanthridines |
WO1999005111A1 (en) * | 1997-07-25 | 1999-02-04 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Novel tetrazole derivatives |
AR015966A1 (en) * | 1997-10-17 | 2001-05-30 | Smithkline Beecham Corp | USE OF A PDE4 INHIBITOR COMPOUND FOR THE PREPARATION OF A USEFUL MEDICINAL PRODUCT FOR PRURITE TREATMENT |
IT1296985B1 (en) * | 1997-12-19 | 1999-08-03 | Zambon Spa | BENZAZINIC DERIVATIVES INHIBITORS OF PHOSPHODIESTERASE 4 |
PT1147087E (en) * | 1999-01-15 | 2005-09-30 | Altana Pharma Ag | FEANTRIDINE-N-OXIDES WITH PDE-IV INHIBITION ACTIVITY |
CA2359449A1 (en) * | 1999-01-15 | 2000-07-20 | Beate Gutterer | Phenanthridine-n-oxides with pde-iv inhibiting activity |
WO2000042018A1 (en) * | 1999-01-15 | 2000-07-20 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Polysubstituted 6-phenylphenanthridines with pde-iv inhibiting activity |
EP1147088B1 (en) * | 1999-01-15 | 2006-01-04 | ALTANA Pharma AG | 6-arylphenanthridines with pde-iv inhibiting activity |
DK1147089T3 (en) * | 1999-01-15 | 2006-04-10 | Altana Pharma Ag | Phenylphenanthridines with PDE-IV inhibitory effect |
ATE320800T1 (en) | 1999-08-21 | 2006-04-15 | Altana Pharma Ag | SYNERGISTIC COMBINATION OF ROFLUMILAST AND SALMETEROL |
AU782908B2 (en) * | 2000-01-11 | 2005-09-08 | Altana Pharma Ag | Phenanthridine-N-oxides |
AU2001281965A1 (en) * | 2000-07-14 | 2002-01-30 | Byk Gulden Lomberg Chemische Fabrik G.M.B.H. | Novel 6-phenylphenanthridines |
EP1303506B1 (en) * | 2000-07-14 | 2005-02-02 | ALTANA Pharma AG | 6-heteroarylphenanthridines |
WO2002006239A1 (en) * | 2000-07-14 | 2002-01-24 | Altana Pharma Ag | Phenanthridine n-oxides |
WO2002006238A1 (en) * | 2000-07-14 | 2002-01-24 | Altana Pharma Ag | Cycloalkyl - or cycloalkylmethyl-substituted 6-phenylphenanthridines |
CA2496459C (en) | 2002-08-29 | 2013-06-25 | Altana Pharma Ag | 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors |
US7329676B2 (en) | 2002-08-29 | 2008-02-12 | Nycomed Gmbh | 2-hydroxy-6-phenylphenanthridines as PDE-4 inhibitors |
JP2007500686A (en) * | 2003-07-31 | 2007-01-18 | アルタナ ファルマ アクチエンゲゼルシャフト | Novel 6-phenylphenanthridine |
EP1658270A1 (en) * | 2003-07-31 | 2006-05-24 | ALTANA Pharma AG | Novel 6-phenylphenantridines |
AU2005212857B2 (en) | 2004-02-18 | 2011-04-28 | Takeda Gmbh | Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (PDE) 4 inhibitors |
EA014155B1 (en) | 2004-03-03 | 2010-10-29 | Никомед Гмбх | Novel hydroxy -6-heteroarylphenanthridines and their use as pde4 inhibitors |
AU2005220034A1 (en) * | 2004-03-09 | 2005-09-15 | Nycomed Gmbh | Novel isoamido-substituted hydroxy-6-phenylphenanthridines and their use as PDE4 inhibitors |
EP1725532A1 (en) * | 2004-03-10 | 2006-11-29 | Altana Pharma AG | Novel difluoroethoxy-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors |
EP1725533A1 (en) * | 2004-03-10 | 2006-11-29 | Altana Pharma AG | Novel thio containing hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors |
AU2006210231A1 (en) | 2005-02-01 | 2006-08-10 | Nycomed Gmbh | Novel 6-pyridylphenanthridines |
AU2006219862A1 (en) * | 2005-03-02 | 2006-09-08 | Nycomed Gmbh | 6-Heteroaryl-1,2,3,4,4a, 10b-hexahydro-phenanthridines as PDE-4 inhibitors for the treatment of inflammatory disorders |
NZ589278A (en) | 2005-03-02 | 2012-04-27 | Nycomed Gmbh | Selected salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives |
WO2007027651A2 (en) * | 2005-08-30 | 2007-03-08 | Abbott Laboratories | Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-iv (dpp-iv) |
UY35543A (en) * | 2013-04-30 | 2014-11-28 | Bayer Cropscience Ag | N- (PHENYLCYCALALKYL) CARBOXAMIDS AND N- (PHENYLCICLOALKYL) NEMATICIDED THIOCARBOXAMIDS |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE786031A (en) * | 1971-07-08 | 1973-01-08 | Rhone Poulenc Sa | NEW DERIVATIVES OF PHENANTHRIDIN, THEIR PREPARATION AND THE MEDICINAL COMPOSITIONS CONTAINING THEM |
US4309545A (en) * | 1980-07-28 | 1982-01-05 | Pfizer Inc. | Oximino-1-hydroxyoctahydrobenzo[c]quinolines and derivatives thereof |
-
1997
- 1997-03-24 PT PT97915422T patent/PT889886E/en unknown
- 1997-03-24 CA CA002250569A patent/CA2250569C/en not_active Expired - Fee Related
- 1997-03-24 DE DE59708265T patent/DE59708265D1/en not_active Expired - Lifetime
- 1997-03-24 AT AT97915422T patent/ATE224386T1/en not_active IP Right Cessation
- 1997-03-24 WO PCT/EP1997/001487 patent/WO1997035854A1/en active IP Right Grant
- 1997-03-24 JP JP53403097A patent/JP4141501B2/en not_active Expired - Fee Related
- 1997-03-24 EP EP97915422A patent/EP0889886B1/en not_active Expired - Lifetime
- 1997-03-24 ES ES97915422T patent/ES2184077T3/en not_active Expired - Lifetime
- 1997-03-24 DK DK97915422T patent/DK0889886T5/en active
- 1997-03-24 SI SI9730427T patent/SI0889886T1/en unknown
- 1997-03-24 AU AU22910/97A patent/AU718752B2/en not_active Ceased
-
2004
- 2004-03-12 CY CY0400018A patent/CY2431B1/en unknown
Also Published As
Publication number | Publication date |
---|---|
DE59708265D1 (en) | 2002-10-24 |
WO1997035854A1 (en) | 1997-10-02 |
EP0889886B1 (en) | 2002-09-18 |
CA2250569A1 (en) | 1997-10-02 |
CA2250569C (en) | 2005-05-10 |
PT889886E (en) | 2003-02-28 |
ES2184077T3 (en) | 2003-04-01 |
AU718752B2 (en) | 2000-04-20 |
AU2291097A (en) | 1997-10-17 |
EP0889886A1 (en) | 1999-01-13 |
JP2000507256A (en) | 2000-06-13 |
JP4141501B2 (en) | 2008-08-27 |
ATE224386T1 (en) | 2002-10-15 |
DK0889886T5 (en) | 2003-02-24 |
DK0889886T3 (en) | 2003-01-20 |
SI0889886T1 (en) | 2003-02-28 |
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