CY1125092T1 - Ιατρικη χρηση σχετικα με επεκταση τελομερους - Google Patents

Ιατρικη χρηση σχετικα με επεκταση τελομερους

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Publication number
CY1125092T1
CY1125092T1 CY20211101135T CY211101135T CY1125092T1 CY 1125092 T1 CY1125092 T1 CY 1125092T1 CY 20211101135 T CY20211101135 T CY 20211101135T CY 211101135 T CY211101135 T CY 211101135T CY 1125092 T1 CY1125092 T1 CY 1125092T1
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CY
Cyprus
Prior art keywords
compositions
cells
compounds
telomeres
telomere extension
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CY20211101135T
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English (en)
Inventor
John Ramunas
Eduard YAKUBOV
Helen M. Blau
John Cooke
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The Board Of Trustees Of The Leland Stanford Junior University
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Application filed by The Board Of Trustees Of The Leland Stanford Junior University filed Critical The Board Of Trustees Of The Leland Stanford Junior University
Publication of CY1125092T1 publication Critical patent/CY1125092T1/el

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Abstract

Παρέχονται ενώσεις και συνθέσεις για την παροδική έκφραση της δραστηριότητας εξωγενούς τελομεράσης σε ένα κύτταρο. Οι ενώσεις και οι συνθέσεις, οι οποίες σχετίζονται με ένα ριβονουκλεϊκό οξύ που κωδικοποιεί μια αντίστροφη μεταγραφάση τελομεράσης, είναι χρήσιμες στην επέκταση των τελομερων σε κύτταρα που χρειάζονται τέτοια επεξεργασία. Τέτοια κύτταρα περιλαμβάνουν, για παράδειγμα, κύτταρα που περιέχουν βραχέα τελομερή και κύτταρα από άτομα που μπορεί να ωφεληθούν από την επέκταση των τελομερών, για παράδειγμα σε άτομα που πάσχουν από ή κινδυνεύουν να υποφέρουν από ασθένειες που σχετίζονται με την ηλικία ή άλλες ασθένειες. Παρέχονται επίσης μέθοδοι επέκτασης τελομερών μέσω της χορήγησης των παρεχόμενων ενώσεων και συνθέσεων σε ζωικά κύτταρα, είτε in vitro είτε in vivo, και κιτ που περιλαμβάνουν τις ενώσεις και τις συνθέσεις και οδηγίες χρήσης.
CY20211101135T 2013-02-22 2021-12-28 Ιατρικη χρηση σχετικα με επεκταση τελομερους CY1125092T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361768047P 2013-02-22 2013-02-22
PCT/US2014/017867 WO2014130909A1 (en) 2013-02-22 2014-02-22 Compounds, compositions, methods, and kits relating to telomere extension

Publications (1)

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CY1125092T1 true CY1125092T1 (el) 2023-03-24

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US (5) US20140242154A1 (el)
EP (2) EP3988112A1 (el)
JP (3) JP2016514953A (el)
CN (2) CN105164269A (el)
AU (1) AU2014218667A1 (el)
CA (1) CA2902237C (el)
CY (1) CY1125092T1 (el)
DK (1) DK2959005T3 (el)
ES (1) ES2901402T3 (el)
HK (1) HK1218934A1 (el)
HR (1) HRP20211842T1 (el)
HU (1) HUE056638T2 (el)
IL (2) IL296870A (el)
LT (1) LT2959005T (el)
PL (1) PL2959005T3 (el)
PT (1) PT2959005T (el)
RS (1) RS62824B1 (el)
RU (2) RU2022101438A (el)
SI (1) SI2959005T1 (el)
WO (1) WO2014130909A1 (el)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX354995B (es) 2011-12-05 2018-03-27 Factor Bioscience Inc Metodos y productos para transfeccion de celulas.
JP6466833B2 (ja) 2012-05-11 2019-02-06 ジェムバックス アンド カエル カンパニー，リミティド 抗炎症活性を有するペプチド、及びそれを含む組成物
WO2014010971A1 (ko) 2012-07-11 2014-01-16 주식회사 카엘젬백스 세포 투과성 펩티드, 그를 포함한 컨쥬게이트 및 그를 포함한 조성물
KR102121086B1 (ko) 2012-11-01 2020-06-09 팩터 바이오사이언스 인크. 세포에서 단백질을 발현시키는 방법들과 생성물들
PT2959005T (pt) 2013-02-22 2021-12-30 Univ Leland Stanford Junior Utilização médica relacionada com extensão de telómero
CN105899079A (zh) 2013-10-30 2016-08-24 密苏里大学的策展人 可扩展性骨骼肌谱系特化和培育的方法
JP6367950B2 (ja) 2013-12-17 2018-08-01 ジェムバックス アンド カエル カンパニー，リミティド 前立腺癌治療用組成物
AU2015210769B2 (en) 2014-01-31 2019-02-07 Factor Bioscience Inc. Methods and products for nucleic acid production and delivery
KR102413243B1 (ko) 2014-12-23 2022-06-27 주식회사 젬백스앤카엘 안질환 치료 펩티드 및 이를 포함하는 안질환 치료용 조성물
EP3240803B1 (en) 2014-12-29 2021-11-24 Novartis AG Methods of making chimeric antigen receptor-expressing cells
JP7199809B2 (ja) 2015-02-13 2023-01-06 ファクター バイオサイエンス インコーポレイテッド 核酸製品及びその投与方法
US10835582B2 (en) 2015-02-27 2020-11-17 Gemvax & Kael Co. Ltd. Peptide for preventing hearing loss, and composition comprising same
EP4234685A3 (en) 2015-04-17 2023-09-06 Novartis AG Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells
DK3317411T3 (da) 2015-06-30 2021-03-15 Ethris Gmbh Atp-bindingskassettefamilie som koder polyribonukleotider og formuleringer deraf
JP6923453B2 (ja) 2015-07-02 2021-08-18 ジェムバックス アンド カエル カンパニー，リミティド 抗ウイルス活性効能を有するペプチド及びこれを含む組成物
SG10201912978PA (en) 2015-07-21 2020-02-27 Novartis Ag Methods for improving the efficacy and expansion of immune cells
CN108431021B (zh) * 2015-11-03 2021-09-07 珍白斯凯尔有限公司 具有神经元损失预防和再生效果的肽以及包含该肽的组合物
US20180360924A1 (en) * 2015-11-25 2018-12-20 The Methodist Hospital System Telomere extension and anti-inflammatory agents for cell regeneration
WO2017176087A1 (ko) 2016-04-07 2017-10-12 주식회사 젬백스앤카엘 텔로머라제 활성 증가 및 텔로미어 연장 효능을 가지는 펩티드 및 이를 포함하는 조성물
US11859232B2 (en) * 2016-06-19 2024-01-02 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Screening for chemotherapy resistance in human haploid cells
AU2017312113B2 (en) 2016-08-17 2023-05-25 Factor Bioscience Inc. Nucleic acid products and methods of administration thereof
WO2018208628A1 (en) 2017-05-06 2018-11-15 Memphis Meats, Inc. Compositions and methods for increasing the culture density of a cellular biomass within a cultivation infrastructure
EP3638777A4 (en) 2017-07-13 2021-05-12 Memphis Meats, Inc. COMPOSITIONS AND METHODS FOR INCREASING THE EFFICIENCY OF CELL CULTURES FOR FOOD MANUFACTURING
BR112020007710A2 (pt) 2017-10-25 2020-10-20 Novartis Ag métodos para produzir células que expressam receptor de antígeno quimérico
US20210171909A1 (en) 2018-08-31 2021-06-10 Novartis Ag Methods of making chimeric antigen receptor?expressing cells
EP3844267A2 (en) 2018-08-31 2021-07-07 Novartis AG Methods of making chimeric antigen receptor-expressing cells
KR20210057024A (ko) * 2018-09-06 2021-05-20 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 텔로머라제 완전효소 복합체 및 이의 사용 방법
JP2022501050A (ja) * 2018-10-02 2022-01-06 ステムオン インコーポレーテッドStemon Inc. 細胞のテロメアを伸長させる方法
KR102209234B1 (ko) * 2018-10-02 2021-02-01 주식회사 스템온 세포의 텔로미어를 신장시키는 방법
WO2020071665A2 (ko) * 2018-10-02 2020-04-09 주식회사 스템온 세포의 텔로미어를 신장시키는 조성물 및 그 제조방법
WO2020163705A1 (en) * 2019-02-08 2020-08-13 Board Of Regents, The University Of Texas System Telomerase-containing exosomes for treatment of diseases associated with aging and age-related organ dysfunction
EP3953455A1 (en) 2019-04-12 2022-02-16 Novartis AG Methods of making chimeric antigen receptor-expressing cells
US20220313782A1 (en) * 2019-05-02 2022-10-06 Board Of Regents, The University Of Texas System Methods and compositions involving tert activating therapies
US10501404B1 (en) 2019-07-30 2019-12-10 Factor Bioscience Inc. Cationic lipids and transfection methods
JP2023503163A (ja) 2019-11-26 2023-01-26 ノバルティス アーゲー キメラ抗原受容体及びその使用
KR20220146437A (ko) * 2020-01-10 2022-11-01 안드라닉 앤드류 아프리키안 목적 유전자의 발현 및/또는 신호전달 경로의 조절을 위한 나노입자
EP4106777A4 (en) * 2020-02-17 2024-03-27 Figene Llc TELOMER LENGTH MODULATION USING FIBROBLASS
KR20220147109A (ko) 2020-02-27 2022-11-02 노파르티스 아게 키메라 항원 수용체 발현 세포의 제조 방법
CN112063601B (zh) * 2020-09-22 2023-06-02 浙江愈方生物科技有限公司 一种灭活性端粒酶、具有其的腺病毒和人造mRNA及应用
JP2024501388A (ja) * 2020-12-29 2024-01-11 リジュベネーション テクノロジーズ インク． Ｒｎａの送達のための組成物および方法
WO2022212576A1 (en) * 2021-03-31 2022-10-06 Rejuvenation Technologies Inc. Compositions and methods for delivery of rna
WO2024056809A1 (en) 2022-09-15 2024-03-21 Novartis Ag Treatment of autoimmune disorders using chimeric antigen receptor therapy

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5686306A (en) 1992-05-13 1997-11-11 Board Of Regents, The University Of Texas System Methods and reagents for lengthening telomeres
US5583016A (en) 1994-07-07 1996-12-10 Geron Corporation Mammalian telomerase
US5770422A (en) 1996-07-08 1998-06-23 The Regents Of The University Of California Human telomerase
DE69739497D1 (de) 1996-10-01 2009-08-27 Geron Corp Menschlische Telomerase katalytische Untereinheit
US6610839B1 (en) 1997-08-14 2003-08-26 Geron Corporation Promoter for telomerase reverse transcriptase
US6093809A (en) 1996-10-01 2000-07-25 University Technology Corporation Telomerase
US8323975B2 (en) 2002-01-04 2012-12-04 The Board Of Trustees Of The Leland Stanford Junior University Telomere-encoding synthetic DNA nanocircles, and their use for the elongation of telomere repeats
US7897752B2 (en) 2002-02-20 2011-03-01 Sirna Therapeutics, Inc. RNA interference mediated inhibition of telomerase gene expression using short interfering nucleic acid (siNA)
CN100393209C (zh) 2003-09-09 2008-06-11 杰龙公司 用于端粒酶抑制的改性寡核苷酸
DE102004035227A1 (de) 2004-07-21 2006-02-16 Curevac Gmbh mRNA-Gemisch zur Vakzinierung gegen Tumorerkrankungen
US9012219B2 (en) 2005-08-23 2015-04-21 The Trustees Of The University Of Pennsylvania RNA preparations comprising purified modified RNA for reprogramming cells
TR201909609T4 (tr) 2005-08-23 2019-07-22 Univ Pennsylvania Modifiye edilmiş nükleosidleri içeren rna ve kullanım yöntemleri.
CA2623256A1 (en) 2005-09-29 2007-04-12 Nektar Therapeutics Receptacles and kits, such as for dry powder packaging
GB0720486D0 (en) 2007-10-19 2007-11-28 Univ Edinburgh Cationic lipids
US20110243957A1 (en) 2008-09-24 2011-10-06 University Of South Florida Materials and methods for preventing or treating neurodegenerative conditions associated with abeta peptide accumulation
CA2783032C (en) 2009-12-07 2022-08-30 Gary Dahl Rna preparations comprising purified modified rna for reprogramming cells
RU2443777C2 (ru) * 2010-03-24 2012-02-27 Учреждение Российской академии медицинских наук Научно-исследовательский институт клинической иммунологии Сибирского отделения РАМН Способ одномоментного определения длины теломер и количества делений популяции пролиферирующих клеток in vitro
CA3122219A1 (en) * 2010-04-16 2011-10-20 The Children's Hospital Corporation Sustained polypeptide expression from synthetic, modified rnas and uses thereof
US20120177611A1 (en) 2010-07-15 2012-07-12 Blau Helen M Elastic substrates and methods of use in cell manipulation and culture
CN102433297A (zh) * 2011-10-14 2012-05-02 黄必录 延伸成体多能干细胞端粒的方法
US8497124B2 (en) 2011-12-05 2013-07-30 Factor Bioscience Inc. Methods and products for reprogramming cells to a less differentiated state
MX354995B (es) 2011-12-05 2018-03-27 Factor Bioscience Inc Metodos y productos para transfeccion de celulas.
LT2791160T (lt) 2011-12-16 2022-06-10 Modernatx, Inc. Modifikuotos mrnr sudėtys
PT2959005T (pt) 2013-02-22 2021-12-30 Univ Leland Stanford Junior Utilização médica relacionada com extensão de telómero
JP6123561B2 (ja) 2013-08-08 2017-05-10 ソニー株式会社 発光素子及びその製造方法、並びに、表示装置

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