CY1124538T1 - Χρηση prg4 για τη βελτιωση της δυναμικης οπτικης οξυτητας και εκτροπων υψηλοτερης ταξης - Google Patents

Χρηση prg4 για τη βελτιωση της δυναμικης οπτικης οξυτητας και εκτροπων υψηλοτερης ταξης

Info

Publication number
CY1124538T1
CY1124538T1 CY20211100858T CY211100858T CY1124538T1 CY 1124538 T1 CY1124538 T1 CY 1124538T1 CY 20211100858 T CY20211100858 T CY 20211100858T CY 211100858 T CY211100858 T CY 211100858T CY 1124538 T1 CY1124538 T1 CY 1124538T1
Authority
CY
Cyprus
Prior art keywords
prg4
abirations
order
visual acuity
dynamic visual
Prior art date
Application number
CY20211100858T
Other languages
English (en)
Inventor
Edward R. Truitt
Benjamin D. Sullivan
Original Assignee
Lubris Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lubris Llc filed Critical Lubris Llc
Publication of CY1124538T1 publication Critical patent/CY1124538T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)
  • Prostheses (AREA)

Abstract

Αποκαλύπτονται μέθοδοι που περιλαμβάνουν τη θεραπευτική χρήση ανθρώπινης PRG4 (λουμπρικίνη) πρωτεΐνης για τη βελτίωση της όρασης για τη μείωση εκτροπών όπως μειωμένη νυχτερινή όραση, φωτοστέφανα και λάμψη, για τη βελτίωση της σταθερότητας του δακρυϊκού υμενίου και για την ομογενοποίηση του δείκτη διάθλασης της επιφανείας του οφθαλμού.
CY20211100858T 2015-05-19 2021-10-05 Χρηση prg4 για τη βελτιωση της δυναμικης οπτικης οξυτητας και εκτροπων υψηλοτερης ταξης CY1124538T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562163753P 2015-05-19 2015-05-19
PCT/US2016/033248 WO2016187414A1 (en) 2015-05-19 2016-05-19 Use of prg4 to improve dynamic visual acuity and higher order aberrations

Publications (1)

Publication Number Publication Date
CY1124538T1 true CY1124538T1 (el) 2022-07-22

Family

ID=57320651

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20211100858T CY1124538T1 (el) 2015-05-19 2021-10-05 Χρηση prg4 για τη βελτιωση της δυναμικης οπτικης οξυτητας και εκτροπων υψηλοτερης ταξης

Country Status (14)

Country Link
US (1) US11666529B2 (el)
EP (1) EP3300482B1 (el)
JP (2) JP7291459B2 (el)
CY (1) CY1124538T1 (el)
DK (1) DK3300482T3 (el)
ES (1) ES2893304T3 (el)
HR (1) HRP20211589T1 (el)
HU (1) HUE056409T2 (el)
LT (1) LT3300482T (el)
MA (1) MA42148A (el)
PL (1) PL3300482T3 (el)
PT (1) PT3300482T (el)
SI (1) SI3300482T1 (el)
WO (1) WO2016187414A1 (el)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9982027B2 (en) 2013-10-22 2018-05-29 Lubris Llc Control of rheological properties of mixed hyaluronate/lubricin solutions
JP6758299B2 (ja) 2015-01-26 2020-09-23 ルブリス，エルエルシー． 抗炎症剤としてのｐｒｇ４の使用
CA3104296A1 (en) * 2018-06-21 2019-12-26 Lubris, Llc Lubricin for use in wound healing

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6433142B1 (en) 1989-08-08 2002-08-13 Genetics Institute, Llc Megakaryocyte stimulating factors
US7001881B1 (en) 1999-04-23 2006-02-21 Rhode Island Hospital Tribonectins
US6960562B2 (en) 1999-04-23 2005-11-01 Rhode Island Hospital, A Lifespan Partner Tribonectin polypeptides and uses thereof
US6743774B1 (en) 1999-04-23 2004-06-01 Rhode Island Hospital Tribonectins
US7415381B2 (en) 2003-01-09 2008-08-19 Rhode Island Hospital, A Lifespan Partner Joint friction sensing
WO2005000331A2 (en) 2003-06-04 2005-01-06 Mucosal Therapeutics, Inc. Compositions for the treatment and prevention of degenerative joint disorders
WO2005102363A2 (en) 2004-04-20 2005-11-03 Mucosal Therapeutics Llc Methods of promoting cartilage healing or cartilage integration
JP2008507553A (ja) 2004-07-23 2008-03-13 ミューコサル セラピューティクス リミテッド ライアビリディ カンパニー 粘性補給のための組成物および方法
US20080139458A1 (en) 2004-12-03 2008-06-12 Jay Gregory D Methods of Treatment For Injured or Diseased Joints
US20070111327A1 (en) 2005-05-05 2007-05-17 Jay Gregory D Methods of detecting lubricin
US8144631B2 (en) 2006-12-13 2012-03-27 Cisco Technology, Inc. Interconnecting IP video endpoints with reduced H.320 call setup time
WO2008143816A1 (en) 2007-05-15 2008-11-27 Mucosal Therapeutics Compositions and methods for reducing friction between the surface of tendons or other soft tissues
US20090068247A1 (en) 2007-09-12 2009-03-12 Mucosal Therapeutics Biocompatible devices coated with a tribonectin and methods for their production
US20090104148A1 (en) 2007-09-18 2009-04-23 Jay Gregory D Treatment and prevention of joint disease
RU2510274C2 (ru) 2008-05-07 2014-03-27 Дзе Реджентс Оф Дзе Юниверсити Оф Калифорния Терапевтическое восстановление и усиление увлажнения поверхности глаза
US8506944B2 (en) 2008-05-07 2013-08-13 The Regents Of The University Of California Replenishment and enrichment of ocular surface lubrication
CN102438645A (zh) 2009-01-13 2012-05-02 卢布里斯有限责任公司 ***上皮界面润滑的治疗调节
CA3110817C (en) 2009-05-22 2023-08-15 Lubris, Llc Application and uses of prg4 and therapeutic modulation thereof
WO2011019963A2 (en) 2009-08-13 2011-02-17 Singularis, Inc. Prg4 treatment for interstitial cystitis
ES2627103T3 (es) 2010-01-19 2017-07-26 Lubris Llc Composiciones de cuidado bucal y métodos
US8480227B2 (en) 2010-07-30 2013-07-09 Novartis Ag Silicone hydrogel lenses with water-rich surfaces
US9974685B2 (en) 2011-08-29 2018-05-22 Mati Therapeutics Drug delivery system and methods of treating open angle glaucoma and ocular hypertension
US20130116186A1 (en) 2011-10-04 2013-05-09 Rhode Island Hospital, A Lifespan Partner Lubricin injections to maintain cartilage health
US9982027B2 (en) 2013-10-22 2018-05-29 Lubris Llc Control of rheological properties of mixed hyaluronate/lubricin solutions
AU2014354859B2 (en) 2013-11-26 2020-04-09 Lubris Llc Compositions and methods for inhibiting intercellular interactions
US20180161393A1 (en) 2015-01-26 2018-06-14 Lubris Llc Prg4 for treating gout and its symptoms
JP6758299B2 (ja) 2015-01-26 2020-09-23 ルブリス，エルエルシー． 抗炎症剤としてのｐｒｇ４の使用
US20170312335A1 (en) 2015-12-30 2017-11-02 Lubris Llc Topical use of prg4 for treatment of allergy and symptoms of inflammation

Also Published As

Publication number Publication date
JP7291459B2 (ja) 2023-06-15
EP3300482A4 (en) 2019-02-13
LT3300482T (lt) 2021-10-25
ES2893304T3 (es) 2022-02-08
EP3300482B1 (en) 2021-07-14
PL3300482T3 (pl) 2022-01-03
HUE056409T2 (hu) 2022-02-28
JP2021167318A (ja) 2021-10-21
PT3300482T (pt) 2021-10-15
HRP20211589T1 (hr) 2022-01-07
US20180140546A1 (en) 2018-05-24
JP2018515534A (ja) 2018-06-14
EP3300482A1 (en) 2018-04-04
US11666529B2 (en) 2023-06-06
MA42148A (fr) 2018-04-04
WO2016187414A1 (en) 2016-11-24
DK3300482T3 (da) 2021-10-18
SI3300482T1 (sl) 2021-11-30

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