CY1124190T1 - Anti-ctla4 μονοκλωνικο αντισωμα ή το θραυσμα δεσμευσης αντιγονου αυτου, φαρμακευτικη συνθεση και χρηση - Google Patents

Anti-ctla4 μονοκλωνικο αντισωμα ή το θραυσμα δεσμευσης αντιγονου αυτου, φαρμακευτικη συνθεση και χρηση

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Publication number
CY1124190T1
CY1124190T1 CY20211100197T CY211100197T CY1124190T1 CY 1124190 T1 CY1124190 T1 CY 1124190T1 CY 20211100197 T CY20211100197 T CY 20211100197T CY 211100197 T CY211100197 T CY 211100197T CY 1124190 T1 CY1124190 T1 CY 1124190T1
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Cyprus
Prior art keywords
monoclonal antibody
antigen
pharmaceutical composition
binding fragment
ctla4 monoclonal
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CY20211100197T
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English (en)
Inventor
Baiyong Li
Yu Xia
Zhongmin Wang
Peng Zhang
Xinghua PANG
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Akeso Biopharma Inc.
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Application filed by Akeso Biopharma Inc. filed Critical Akeso Biopharma Inc.
Publication of CY1124190T1 publication Critical patent/CY1124190T1/el

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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
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    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70521—CD28, CD152

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Abstract

Η παρούσα εφεύρεση ανήκει στα πεδία της θεραπείας όγκων και της μοριακής ανοσολογίας και παρέχει ένα αντι-CTLA4 μονοκλωνικό αντίσωμα ή το θραύσμα δέσμευσης αντιγόνου αυτού, μια φαρμακευτική σύνθεση του και τη χρήση του. Το μονοκλωνικό αντίσωμα της παρούσας εφεύρεσης μπορεί να εμποδίσει τη δέσμευση του CLTA4 στο Β7, να ανακουφίσει την ανοσοκαταστολή στο σώμα μέσω του CTLA4 και να ενεργοποιήσει τα Τ λεμφοκύτταρα.
CY20211100197T 2014-08-01 2021-03-08 Anti-ctla4 μονοκλωνικο αντισωμα ή το θραυσμα δεσμευσης αντιγονου αυτου, φαρμακευτικη συνθεση και χρηση CY1124190T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201410377352.9A CN105296433B (zh) 2014-08-01 2014-08-01 一种ctla4抗体、其药物组合物及其用途
PCT/CN2015/085721 WO2016015675A1 (zh) 2014-08-01 2015-07-31 抗ctla4的单克隆抗体或其抗原结合片段、药物组合物及用途

Publications (1)

Publication Number Publication Date
CY1124190T1 true CY1124190T1 (el) 2022-05-27

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US (3) US10449251B2 (el)
EP (2) EP3176181B1 (el)
JP (2) JP6514774B2 (el)
KR (1) KR102017396B1 (el)
CN (3) CN105296433B (el)
AP (1) AP2017009762A0 (el)
AU (2) AU2015295936C1 (el)
BR (1) BR112017002080A2 (el)
CA (1) CA2956000C (el)
CL (1) CL2017000250A1 (el)
CO (1) CO2017000754A2 (el)
CR (1) CR20170033A (el)
CY (1) CY1124190T1 (el)
DK (1) DK3176181T3 (el)
DO (1) DOP2017000031A (el)
EA (1) EA036396B1 (el)
EC (1) ECSP17012781A (el)
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GE (1) GEP20207166B (el)
HR (1) HRP20210448T1 (el)
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MA (2) MA40474B1 (el)
MD (1) MD4795C1 (el)
MX (2) MX2017001446A (el)
MY (1) MY192822A (el)
NI (1) NI201700008A (el)
NZ (1) NZ729158A (el)
PE (1) PE20170772A1 (el)
PH (1) PH12017500190A1 (el)
PL (1) PL3176181T3 (el)
PT (1) PT3176181T (el)
RS (1) RS61590B1 (el)
SG (1) SG11201700819QA (el)
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TN (1) TN2017000010A1 (el)
UA (1) UA119570C2 (el)
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ZA (1) ZA201700528B (el)

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