CY1123735T1 - Φαρμακευτικη χρηση toy fam19a5 που εμπλεκεται στη ρυθμιση γλοιογενησης - Google Patents

Φαρμακευτικη χρηση toy fam19a5 που εμπλεκεται στη ρυθμιση γλοιογενησης

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Publication number
CY1123735T1
CY1123735T1 CY20201101116T CY201101116T CY1123735T1 CY 1123735 T1 CY1123735 T1 CY 1123735T1 CY 20201101116 T CY20201101116 T CY 20201101116T CY 201101116 T CY201101116 T CY 201101116T CY 1123735 T1 CY1123735 T1 CY 1123735T1
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CY
Cyprus
Prior art keywords
fam19a5
gliogenesis
involved
regulation
pharmaceutical use
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Application number
CY20201101116T
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English (en)
Inventor
Jae Young Seong
Jong Ik Hwang
Woong Sun
Eun Bee Cho
Won-Ki Kim
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Neuracle Science Co., Ltd.
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Publication date
Application filed by Neuracle Science Co., Ltd. filed Critical Neuracle Science Co., Ltd.
Publication of CY1123735T1 publication Critical patent/CY1123735T1/el

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
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    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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Abstract

Η παρούσα εφεύρεση αφορά στη φαρμακευτική χρήση του FAM19A5 που εμπλέκεται στη ρύθμιση της γλοιογένεσης, και πιο συγκεκριμένα, στη χρήση του FAM19Α5 στην πρόληψη, διάγνωση ή θεραπεία βλαβών του κεντρικού νευρικού συστήματος, εκφυλιστικών εγκεφαλικών ασθενειών ή ασθενειών του κεντρικού νευρικού συστήματος, με το FAM19A5 εξαπλώνεται στα νευρικά βλαστοκύτταρα στα σπονδυλωτά και να ρυθμίζει τη γλοιογένεση.
CY20201101116T 2012-02-15 2020-11-25 Φαρμακευτικη χρηση toy fam19a5 που εμπλεκεται στη ρυθμιση γλοιογενησης CY1123735T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20120015177 2012-02-15
PCT/KR2013/001179 WO2013122408A1 (ko) 2012-02-15 2013-02-15 신경교세포 생성 조절에 관여하는 fam19a5의 약제학적 용도

Publications (1)

Publication Number Publication Date
CY1123735T1 true CY1123735T1 (el) 2022-03-24

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CY20201101116T CY1123735T1 (el) 2012-02-15 2020-11-25 Φαρμακευτικη χρηση toy fam19a5 που εμπλεκεται στη ρυθμιση γλοιογενησης

Country Status (12)

Country Link
US (4) US9579398B2 (el)
EP (2) EP3827848A1 (el)
KR (1) KR101406393B1 (el)
CN (2) CN104254343A (el)
CY (1) CY1123735T1 (el)
DK (1) DK2815769T3 (el)
ES (1) ES2838814T3 (el)
HU (1) HUE052286T2 (el)
LT (1) LT2815769T (el)
PL (1) PL2815769T3 (el)
PT (1) PT2815769T (el)
WO (1) WO2013122408A1 (el)

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WO2013122408A1 (ko) 2012-02-15 2013-08-22 고려대학교 산학협력단 신경교세포 생성 조절에 관여하는 fam19a5의 약제학적 용도
WO2014200030A1 (ja) * 2013-06-12 2014-12-18 国立大学法人京都大学 人工多能性幹細胞の選別方法および血球への分化誘導方法
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JP7045724B2 (ja) * 2016-11-07 2022-04-01 ニューラクル サイエンス カンパニー リミテッド 配列類似性を持つ抗ファミリー１９、メンバーａ５抗体及びその用途
US11560425B2 (en) * 2017-06-27 2023-01-24 Neuracle Science Co., Ltd. Use of anti-FAM19A5 antibodies for treating cancers
JP7034499B2 (ja) * 2017-06-27 2022-03-14 ニューラクル サイエンス カンパニー リミテッド 線維症の治療のための抗ｆａｍ１９ａ５抗体の用途
KR102472683B1 (ko) * 2017-06-27 2022-12-01 주식회사 뉴라클사이언스 녹내장의 치료를 위한 항-서열 유사성 19를 가진 패밀리, 멤버 a5 항체의 용도
EP3645563A4 (en) * 2017-06-27 2021-03-17 Neuracle Science Co., Ltd ANTI-FAM19A5 ANTIBODIES AND THEIR USES
WO2019069229A1 (en) * 2017-10-02 2019-04-11 Neuracle Science Co., Ltd. USE OF ANTIBODIES DIRECTED AGAINST A SIMILARITY FAMILY OF SEQUENCE 19, ELEMENT A5, FOR THE TREATMENT AND DIAGNOSIS OF MOOD DISORDERS
CN110386973B (zh) * 2018-04-18 2022-09-27 北京大学 具有多种功能的蛋白多肽及其医药用途
CN112424223A (zh) * 2018-04-24 2021-02-26 纽洛可科学有限公司 抗序列相似家族19成员a5的抗体在治疗神经性疼痛中的用途
AU2019265855A1 (en) * 2018-05-08 2020-11-26 Neuracle Genetics Adeno-associated virus (AAV) delivery of anti-FAM19A5 antibodies
KR102661891B1 (ko) * 2018-05-10 2024-05-23 주식회사 뉴라클사이언스 서열 유사성 19, 멤버 a5 항체를 갖는 항-패밀리 및 그의 사용 방법
US20210347872A1 (en) * 2018-10-16 2021-11-11 Neuracle Science Co., Ltd. Use of anti-fam19a5 antibodies
CN113227139A (zh) * 2018-12-27 2021-08-06 纽洛可科学有限公司 抗fam19a5抗体治疗动脉粥样硬化的用途
EP3906260A4 (en) * 2019-01-02 2022-08-31 Neuracle Science Co., Ltd SEQUENCE-LIKE ANTI-FAMILY ANTIBODIES 19, MEMBER A5 AND METHOD OF USE THEREOF
KR102328773B1 (ko) * 2019-04-23 2021-11-19 고려대학교 산학협력단 Fam19a5l 유전자를 녹아웃 시킨 제브라피쉬 동물모델 및 이의 제조방법
US20230104540A1 (en) * 2020-03-02 2023-04-06 Neuracle Science Co., Ltd. Use of anti-fam19a1 antagonists for treating central nervous system diseases
CN113491764B (zh) * 2020-04-03 2023-09-19 北京大学 Fam19a5的医药用途
IL310026A (en) * 2021-07-08 2024-03-01 Neuracle Science Co Ltd Inhibitors and methods of using them
EP4367128A1 (en) * 2021-07-08 2024-05-15 Neuracle Science Co., Ltd. Polypeptide inhibitors and uses thereof

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US20200270337A1 (en) 2020-08-27
WO2013122408A1 (ko) 2013-08-22
LT2815769T (lt) 2020-11-25
US20170121401A1 (en) 2017-05-04
US20150118230A1 (en) 2015-04-30
CN104254343A (zh) 2014-12-31
CN107019800A (zh) 2017-08-08
PT2815769T (pt) 2020-12-07
US11739141B2 (en) 2023-08-29
DK2815769T3 (da) 2020-12-14
EP2815769A4 (en) 2015-08-19
US9579398B2 (en) 2017-02-28
EP3827848A1 (en) 2021-06-02
PL2815769T3 (pl) 2021-05-04
HUE052286T2 (hu) 2021-04-28
KR20130094255A (ko) 2013-08-23
KR101406393B1 (ko) 2014-06-13
ES2838814T3 (es) 2021-07-02
EP2815769A1 (en) 2014-12-24
US10640557B2 (en) 2020-05-05
EP2815769B1 (en) 2020-10-21

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