CY1122790T1 - Αντι-ανθρωπινου ιου των θηλωματων 16 ε7 τ κυτταρου υποδοχεις - Google Patents
Αντι-ανθρωπινου ιου των θηλωματων 16 ε7 τ κυτταρου υποδοχειςInfo
- Publication number
- CY1122790T1 CY1122790T1 CY20201100238T CY201100238T CY1122790T1 CY 1122790 T1 CY1122790 T1 CY 1122790T1 CY 20201100238 T CY20201100238 T CY 20201100238T CY 201100238 T CY201100238 T CY 201100238T CY 1122790 T1 CY1122790 T1 CY 1122790T1
- Authority
- CY
- Cyprus
- Prior art keywords
- hpv
- condition
- cell receptor
- human mammal
- mammal
- Prior art date
Links
- 108091008874 T cell receptors Proteins 0.000 title abstract 4
- 241000124008 Mammalia Species 0.000 title abstract 3
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 title abstract 3
- 241000700605 Viruses Species 0.000 title 1
- 241000701806 Human papillomavirus Species 0.000 abstract 4
- 210000004027 cell Anatomy 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 102000025850 HLA-A2 Antigen Human genes 0.000 abstract 1
- 108010074032 HLA-A2 Antigen Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 238000003259 recombinant expression Methods 0.000 abstract 1
- 230000009258 tissue cross reactivity Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
- C07K16/084—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/01—DNA viruses
- G01N2333/025—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Wood Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
Abstract
Αποκαλυπτόμενος είναι ένας συνθετικός υποδοχέας Τ κυττάρου (ΤCR) που έχει αντιγονική ειδικότητα για ΗLΑ-Α2 περιορισμένο επίτοπο του ανθρώπινου ιού των θηλωμάτων (ΗΡV) 16 Ε7, Ε711-19. Σχετικά πολυπεπτίδια και πρωτεΐνες, καθώς επίσης σχετικά νουκλεϊνικά οξέα, ανασυνδυαστικοί φορείς έκφρασης, κύτταρα ξενιστές και πληθυσμοί κυττάρων επίσης παρέχονται. Αντισώματα ή τμήμα σύνδεσης αντιγόνου αυτών και φαρμακευτικές συνθέσεις που αφορούν τους ΤCRs της εφεύρεσης επίσης παρέχονται. Επίσης αποκαλυπτόμενες είναι μέθοδοι ανίχνευσης της παρουσίας μιας κατάστασης σε ένα θηλαστικό και μέθοδοι θεραπείας ή πρόληψης μιας κατάστασης σε ένα θηλαστικό, όπου η κατάσταση είναι καρκίνος, ΗΡV 16 μόλυνση ή ΗΡV-θετική προκακοήθεια.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462004335P | 2014-05-29 | 2014-05-29 | |
PCT/US2015/033129 WO2015184228A1 (en) | 2014-05-29 | 2015-05-29 | Anti-human papillomavirus 16 e7 t cell receptors |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1122790T1 true CY1122790T1 (el) | 2021-05-05 |
Family
ID=53396593
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20201100238T CY1122790T1 (el) | 2014-05-29 | 2020-03-16 | Αντι-ανθρωπινου ιου των θηλωματων 16 ε7 τ κυτταρου υποδοχεις |
Country Status (20)
Country | Link |
---|---|
US (4) | US10174098B2 (el) |
EP (2) | EP3149031B1 (el) |
JP (4) | JP6742991B2 (el) |
KR (2) | KR102618267B1 (el) |
CN (2) | CN113150112B (el) |
AU (4) | AU2015266818B2 (el) |
BR (1) | BR112016027805A2 (el) |
CA (1) | CA2950192A1 (el) |
CY (1) | CY1122790T1 (el) |
DK (1) | DK3149031T3 (el) |
ES (1) | ES2784237T3 (el) |
HR (1) | HRP20200376T1 (el) |
IL (3) | IL290655B2 (el) |
LT (1) | LT3149031T (el) |
MX (2) | MX2016015383A (el) |
PL (1) | PL3149031T3 (el) |
PT (1) | PT3149031T (el) |
SA (1) | SA516380394B1 (el) |
SI (1) | SI3149031T1 (el) |
WO (1) | WO2015184228A1 (el) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LT3149031T (lt) * | 2014-05-29 | 2020-05-25 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | T ląstelių receptoriai prieš žmogaus papilomos virusą 16 e7 |
CA2984234C (en) * | 2015-05-01 | 2023-10-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of isolating t cells and t cell receptors having antigenic specificity for a cancer-specific mutation from peripheral blood |
US10975436B2 (en) | 2016-01-05 | 2021-04-13 | Diamir, Llc | Methods of using miRNA from bodily fluids for diagnosis and monitoring of neurodevelopmental disorders |
WO2017139199A1 (en) | 2016-02-10 | 2017-08-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Inducible arginase |
RU2019112860A (ru) | 2016-09-27 | 2020-10-30 | Серо Терапьютикс, Инк. | Молекулы химерных интернализационных рецепторов |
CN110139873A (zh) * | 2016-10-03 | 2019-08-16 | 朱诺治疗学股份有限公司 | Hpv特异性结合分子 |
AU2017366739B2 (en) * | 2016-12-02 | 2023-11-23 | University Of Southern California | Synthetic immune receptors and methods of use thereof |
GB201700621D0 (en) | 2017-01-13 | 2017-03-01 | Guest Ryan Dominic | Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue |
CA3062433A1 (en) * | 2017-05-15 | 2018-11-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Bicistronic chimeric antigen receptors and their uses |
MA49512A (fr) * | 2017-06-28 | 2020-05-06 | Regeneron Pharma | Protéines de liaison à l'antigène anti-papillomavirus humain et leurs méthodés d'utilisation |
KR20200100598A (ko) | 2017-09-26 | 2020-08-26 | 세로 테라퓨틱스, 인코포레이티드 | 키메라 포식작용 수용체 분자 및 사용 방법 |
US11939365B2 (en) | 2017-09-29 | 2024-03-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | T cell receptors recognizing mutated P53 |
KR20200104284A (ko) * | 2017-10-03 | 2020-09-03 | 주노 쎄러퓨티크스 인코퍼레이티드 | Hpv-특이적 결합 분자 |
JP2020535832A (ja) * | 2017-10-05 | 2020-12-10 | アメリカ合衆国 | マウス定常領域を伴うtcrを発現する細胞を選択的に増幅するための方法 |
JP2021502077A (ja) | 2017-11-06 | 2021-01-28 | エディタス・メディシン,インコーポレイテッド | 免疫療法のためのt細胞におけるcblbのcrispr−cas9編集のための方法、組成物および構成要素 |
US20210052647A1 (en) | 2018-02-09 | 2021-02-25 | The United States Of America,As Represented By The Secretary,Department Of Health And Human Services | Tethered interleukin-15 and interleukin-21 |
AU2019243153A1 (en) | 2018-03-28 | 2020-10-01 | Cero Therapeutics, Inc. | Expression vectors for chimeric engulfment receptors, genetically modified host cells, and uses thereof |
US20210023135A1 (en) | 2018-03-28 | 2021-01-28 | Cero Therapeutics, Inc. | Cellular immunotherapy compositions and uses thereof |
CN112566698A (zh) | 2018-04-05 | 2021-03-26 | 朱诺治疗学股份有限公司 | T细胞受体和表达该t细胞受体的工程化细胞 |
BR112020020245A2 (pt) | 2018-04-05 | 2021-04-06 | Editas Medicine, Inc. | Métodos de produzir células expressando um receptor recombinante e composições relacionadas |
RU2020136054A (ru) | 2018-04-05 | 2022-05-06 | Джуно Терапьютикс, Инк. | Т-клетки, экспрессирующие рекомбинантный рецептор, соответствующие полинуклеотиды и способы |
WO2019209715A1 (en) | 2018-04-24 | 2019-10-31 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of producing t cell populations using hydroxycitric acid and/or a salt thereof |
WO2019243888A1 (en) * | 2018-06-22 | 2019-12-26 | Kite Pharma Eu B.V. | Compositions and methods for making engineered t cells |
US20210163893A1 (en) | 2018-08-09 | 2021-06-03 | Juno Therapeutics, Inc. | Processes for generating engineered cells and compositions thereof |
CN113167796A (zh) | 2018-09-11 | 2021-07-23 | 朱诺治疗学股份有限公司 | 对工程化细胞组合物进行质谱分析的方法 |
CN113727998A (zh) | 2018-11-30 | 2021-11-30 | 高山免疫科学股份有限公司 | Cd86变体免疫调节蛋白及其用途 |
MX2021013219A (es) | 2019-05-01 | 2022-02-17 | Juno Therapeutics Inc | Celulas que expresan un receptor recombinante de un locus de tgfbr2 modificado, polinucleotidos relacionados y metodos. |
JP2022538148A (ja) | 2019-06-27 | 2022-08-31 | アメリカ合衆国 | p53におけるR175H又はY220C変異を認識するT細胞受容体 |
CN110357952B (zh) * | 2019-07-17 | 2022-03-22 | 深圳市因诺转化医学研究院 | 识别人***瘤病毒hpv16-e7抗原的tcr |
AU2020408017A1 (en) | 2019-12-20 | 2022-07-14 | Instil Bio (Uk) Limited | Devices and methods for isolating tumor infiltrating lymphocytes and uses thereof |
WO2021135178A1 (zh) * | 2019-12-30 | 2021-07-08 | 华夏英泰(北京)生物技术有限公司 | 一种增强型t细胞受体star及其应用 |
CN113072635B (zh) * | 2020-01-06 | 2023-08-25 | 香雪生命科学技术(广东)有限公司 | 一种识别hpv抗原的t细胞受体及其编码序列 |
US20240148869A1 (en) * | 2020-05-07 | 2024-05-09 | China Immunotech (Beijing) Biotechnology Co., Ltd | Improved T cell receptor-costimulatory molecule chimera |
CN116096740A (zh) * | 2020-06-09 | 2023-05-09 | 得克萨斯州大学***董事会 | 经改造t细胞受体和使用方法 |
US20240216508A1 (en) | 2020-06-26 | 2024-07-04 | Juno Therapeutics Gmbh | Engineered t cells conditionally expressing a recombinant receptor, related polynucleotides and methods |
CA3191186A1 (en) | 2020-09-04 | 2022-03-10 | Sanghyun Kim | T cell receptors recognizing r273c or y220c mutations in p53 |
WO2022060904A1 (en) * | 2020-09-16 | 2022-03-24 | Obsidian Therapeutics, Inc. | Compositions and methods for expression of t-cell receptors with small molecule-regulated cd40l in t cells |
US20240018210A1 (en) | 2020-11-13 | 2024-01-18 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic | Enhanced antigen reactivity of immune cells expressing a mutant non-signaling cd3 zeta chain |
JP2024518378A (ja) | 2021-05-05 | 2024-05-01 | イマティクス バイオテクノロジーズ ゲーエムベーハー | Prameに特異的に結合する抗原結合タンパク質 |
CN117957245A (zh) | 2021-05-07 | 2024-04-30 | 美国政府(由卫生和人类服务部的部长所代表) | 识别p53中的c135y、r175h或m237i突变的t细胞受体 |
CN117897411A (zh) * | 2021-06-30 | 2024-04-16 | 华夏英泰(北京)生物技术有限公司 | 一种多靶点合成t细胞受体抗原/抗体受体及其应用 |
CN116157528A (zh) * | 2021-09-07 | 2023-05-23 | 北京可瑞生物科技有限公司 | 抗原结合蛋白及其用途 |
CN118265721A (zh) * | 2021-10-18 | 2024-06-28 | 得克萨斯州大学***董事会 | 靶向ndc80抗原的肽和经改造t细胞受体及使用方法 |
WO2023081900A1 (en) | 2021-11-08 | 2023-05-11 | Juno Therapeutics, Inc. | Engineered t cells expressing a recombinant t cell receptor (tcr) and related systems and methods |
IL312550A (en) * | 2021-11-10 | 2024-07-01 | Tscan Therapeutics Inc | Binding proteins that recognize HPV16 E7 antigen and uses thereof |
WO2023137472A2 (en) | 2022-01-14 | 2023-07-20 | Tune Therapeutics, Inc. | Compositions, systems, and methods for programming t cell phenotypes through targeted gene repression |
WO2023137471A1 (en) | 2022-01-14 | 2023-07-20 | Tune Therapeutics, Inc. | Compositions, systems, and methods for programming t cell phenotypes through targeted gene activation |
WO2023172883A1 (en) | 2022-03-07 | 2023-09-14 | Alpine Immune Sciences, Inc. | Immunomodulatory proteins of variant cd80 polypeptides, cell therapies thereof and related methods and uses |
WO2023196884A1 (en) | 2022-04-06 | 2023-10-12 | Juno Therapeutics, Inc. | Detection assay for human papillomavirus (hpv) type 16 (hpv-16) |
WO2024064642A2 (en) | 2022-09-19 | 2024-03-28 | Tune Therapeutics, Inc. | Compositions, systems, and methods for modulating t cell function |
CN116731155B (zh) * | 2022-09-21 | 2024-03-22 | 新景智源生物科技(苏州)有限公司 | 人***瘤病毒特异性t细胞受体、表达其的细胞和其用途 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
IN165717B (el) | 1986-08-07 | 1989-12-23 | Battelle Memorial Institute | |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
DE69127627T2 (de) | 1990-08-29 | 1998-02-19 | Genpharm Int | Produktion und Nützung nicht-menschliche transgentiere zur Produktion heterologe Antikörper |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
JP3266311B2 (ja) | 1991-05-02 | 2002-03-18 | 生化学工業株式会社 | 新規ポリペプチドおよびこれを用いる抗hiv剤 |
US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
US6265150B1 (en) | 1995-06-07 | 2001-07-24 | Becton Dickinson & Company | Phage antibodies |
US5714352A (en) | 1996-03-20 | 1998-02-03 | Xenotech Incorporated | Directed switch-mediated DNA recombination |
JP2004511425A (ja) | 2000-02-08 | 2004-04-15 | ザ ペン ステート リサーチ ファウンデーション | 免疫療法に使用されるインターロイキン13受容体サブユニットアルファー2 |
EP1545204B1 (en) | 2002-09-06 | 2016-08-10 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Immunotherapy with in vitro-selected antigen-specific lymphocytes after nonmyeloablative lymphodepleting chemotherapy |
JP2008535826A (ja) * | 2005-04-01 | 2008-09-04 | メディジーン リミテッド | 高親和性hivt細胞レセプター |
DK2016102T3 (da) | 2006-05-03 | 2012-07-02 | Us Gov Health & Human Serv | Kimære T-cellereceptorer og tilhørende materialer og fremgangsmåder til anvendelse |
JP6035503B2 (ja) | 2007-05-31 | 2016-11-30 | アカデミシュ ジーケンハウス ライデン ハー.オー.デー.エン. ルムク | ワクチンで使用するための、子宮頸部悪性腫瘍に浸潤するt細胞によって標的とされるhpvエピトープ |
US8383099B2 (en) | 2009-08-28 | 2013-02-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Adoptive cell therapy with young T cells |
GB0917090D0 (en) * | 2009-09-29 | 2009-11-11 | Ucl Biomedica Plc | T-cell receptor |
WO2012129201A1 (en) | 2011-03-22 | 2012-09-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of growing tumor infiltrating lymphocytes in gas-permeable containers |
EP3572423B1 (en) | 2013-07-15 | 2023-12-06 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Anti-human papillomavirus 16 e6 t cell receptors |
LT3149031T (lt) * | 2014-05-29 | 2020-05-25 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | T ląstelių receptoriai prieš žmogaus papilomos virusą 16 e7 |
-
2015
- 2015-05-29 LT LTEP15729004.0T patent/LT3149031T/lt unknown
- 2015-05-29 JP JP2017515021A patent/JP6742991B2/ja active Active
- 2015-05-29 IL IL290655A patent/IL290655B2/en unknown
- 2015-05-29 AU AU2015266818A patent/AU2015266818B2/en active Active
- 2015-05-29 WO PCT/US2015/033129 patent/WO2015184228A1/en active Application Filing
- 2015-05-29 KR KR1020227032043A patent/KR102618267B1/ko active IP Right Grant
- 2015-05-29 US US15/313,673 patent/US10174098B2/en active Active
- 2015-05-29 EP EP15729004.0A patent/EP3149031B1/en active Active
- 2015-05-29 KR KR1020167033189A patent/KR102445667B1/ko active IP Right Grant
- 2015-05-29 EP EP19217074.4A patent/EP3689900A1/en active Pending
- 2015-05-29 SI SI201531126T patent/SI3149031T1/sl unknown
- 2015-05-29 CA CA2950192A patent/CA2950192A1/en active Pending
- 2015-05-29 ES ES15729004T patent/ES2784237T3/es active Active
- 2015-05-29 DK DK15729004.0T patent/DK3149031T3/da active
- 2015-05-29 CN CN202110399056.9A patent/CN113150112B/zh active Active
- 2015-05-29 MX MX2016015383A patent/MX2016015383A/es active IP Right Grant
- 2015-05-29 BR BR112016027805A patent/BR112016027805A2/pt active Search and Examination
- 2015-05-29 PL PL15729004T patent/PL3149031T3/pl unknown
- 2015-05-29 CN CN201580031789.XA patent/CN106661098B/zh active Active
- 2015-05-29 PT PT157290040T patent/PT3149031T/pt unknown
-
2016
- 2016-11-07 IL IL248797A patent/IL248797B/en active IP Right Grant
- 2016-11-24 MX MX2020010035A patent/MX2020010035A/es unknown
- 2016-11-29 SA SA516380394A patent/SA516380394B1/ar unknown
-
2018
- 2018-11-30 US US16/205,631 patent/US10870687B2/en active Active
-
2019
- 2019-12-18 AU AU2019283892A patent/AU2019283892B2/en active Active
-
2020
- 2020-03-06 HR HRP20200376TT patent/HRP20200376T1/hr unknown
- 2020-03-16 CY CY20201100238T patent/CY1122790T1/el unknown
- 2020-07-29 JP JP2020127833A patent/JP6997267B2/ja active Active
- 2020-11-23 US US17/101,360 patent/US11434272B2/en active Active
-
2021
- 2021-04-13 AU AU2021202227A patent/AU2021202227B2/en active Active
- 2021-04-21 IL IL282518A patent/IL282518B/en unknown
- 2021-12-16 JP JP2021203953A patent/JP7291196B2/ja active Active
-
2022
- 2022-08-01 US US17/816,496 patent/US20220372103A1/en active Pending
-
2023
- 2023-02-06 AU AU2023200608A patent/AU2023200608A1/en active Pending
- 2023-06-02 JP JP2023091878A patent/JP2023110036A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1122790T1 (el) | Αντι-ανθρωπινου ιου των θηλωματων 16 ε7 τ κυτταρου υποδοχεις | |
CY1120489T1 (el) | Εμβολια για hsv-2 | |
EA202091335A1 (ru) | Ограниченные hla класса i t-клеточные рецепторы против мутантного ras | |
AR112902A1 (es) | Receptores de células t restringidas a hla de clase ii contra ras mutado | |
MD3551660T2 (ro) | Anticorpi anti-CTLA-4 și procedee de utilizare a acestora | |
EA201891459A1 (ru) | Новое поколение антигенспецифических tcr | |
BR112017003108A2 (pt) | anticorpo ou fragmento de ligação a antígeno do mesmo, polipeptídeo isolado, ácido nucleico isolado, vetor de expressão, célula hospedeira, composição, métodos para produção de um anticorpo ou fragmento de ligação a antígeno, para tratamento de câncer e de uma infecção ou doença infecciosa, para detecção da presença de um peptídeo de tigit ou um fragmento do mesmo e para aumentar a atividade de uma célula imune e a atividade antitumoral de um anticorpo anti-tigit, vacina, e, uso de um anticorpo ou fragmento de ligação a antígeno | |
BR112017006203A2 (pt) | anticorpos isolado, caninizado e monoclonal ou fragmento de ligação ao antígeno dos mesmos, ácido nucleico isolado, vetor de expressão, célula hospedeira, peptídeo antigênico isolado, proteína de fusão, composição farmacêutica, e, método de aumento da atividade de uma célula imune. | |
CY1121466T1 (el) | Αντισωματα εναντι προσδεματων υποδοχεα β1 βραδυκινινης | |
NZ758023A (en) | Methods of predicting ancestral virus sequences and uses thereof | |
EA202090757A1 (ru) | T-КЛЕТОЧНЫЕ РЕЦЕПТОРЫ, РАСПОЗНАЮЩИЕ МУТАНТНЫЙ p53 | |
TR201910103T4 (tr) | Anti-fcrn antikorları. | |
CL2019000366A1 (es) | Nuevos receptores de linfocitos t e inmunoterapia basada en el uso de los mismos. | |
CO2017007105A2 (es) | Nuevos virus de tilapia | |
CY1122436T1 (el) | Αντισωματα εναντι του υποδοχεα του επιδερμικου αυξητικου παραγοντα (egfr) | |
BR112018006006A2 (pt) | receptores de antígeno, cadeias peptídicas, células recombinantes, métodos para produzir uma célula que expressa um receptor de antígeno e para o tratamento de uma doença, ácidos nucleicos e composição farmacêutica | |
CY1123520T1 (el) | Μεθοδοι για την προβλεψη της χρησιμοτητας των νεων αντιγονων για ανοσοθεραπεια | |
EA201890042A1 (ru) | Вакцина против вируса ящура (вя) на основе рекомбинантного модифицированного вируса осповакцины анкара (mva) | |
WO2019099723A3 (en) | Materials and methods relating to immunogenic epitopes from human papillomavirus | |
MX2016013584A (es) | Parvovirus porcino. | |
EA201791957A1 (ru) | Маркерная система, в частности, для экспрессируемых бакуловирусом субъединичных антигенов | |
EA201790296A1 (ru) | Вакцина в виде рекомбинантного вектора на основе птичьего аденовируса серотипа 9 | |
MX2015013304A (es) | Vacunas de nucleoproteina de la influenza. | |
MX2019007924A (es) | Vacunas contra la influenza. | |
BR112017019776A2 (pt) | proteínas de fusão que compreendem glicoproteínas de superfície de alfavírus modificadas e antígeno associado a tumor e métodos dos mesmos |