CY1119918T1 - Συνθεσεις γαμμα-υδροξυβουτυρικου και η χρηση τους για την αντιμετωπιση διαταραχων - Google Patents
Συνθεσεις γαμμα-υδροξυβουτυρικου και η χρηση τους για την αντιμετωπιση διαταραχωνInfo
- Publication number
- CY1119918T1 CY1119918T1 CY20181100181T CY181100181T CY1119918T1 CY 1119918 T1 CY1119918 T1 CY 1119918T1 CY 20181100181 T CY20181100181 T CY 20181100181T CY 181100181 T CY181100181 T CY 181100181T CY 1119918 T1 CY1119918 T1 CY 1119918T1
- Authority
- CY
- Cyprus
- Prior art keywords
- disorders
- treatment
- gamma
- hydroxybutyrate
- dyspnea
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Παρέχονται στο παρόν φαρμακευτικές συνθέσεις και σκευάσματα που περιλαμβάνουν μεικτά άλατα γάμμα-υδροξυβουτυρικού (GHB). Επίσης παρέχονται στο παρόν μέθοδοι παρασκευής των φαρμακευτικών συνθέσεων και σκευασμάτων, και μέθοδοι της χρήσης τους για την αντιμετώπιση διαταραχών του ύπνου όπως άπνοια, διαταραχές του χρόνου του ύπνου, ναρκοληψία, καταπληξία, υπνική παράλυση, υπναγωγικές παραισθήσεις, σεξουαλική διέγερση κατά τον ύπνο, αϋπνία, και νυχτερινή μυοκλονία.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261737695P | 2012-12-14 | 2012-12-14 | |
| PCT/US2013/074954 WO2014093791A1 (en) | 2012-12-14 | 2013-12-13 | Gamma-hydroxybutyrate compositions and their use for the treatment of disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1119918T1 true CY1119918T1 (el) | 2018-06-27 |
Family
ID=49596603
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20181100181T CY1119918T1 (el) | 2012-12-14 | 2018-02-14 | Συνθεσεις γαμμα-υδροξυβουτυρικου και η χρηση τους για την αντιμετωπιση διαταραχων |
| CY20201101030T CY1123498T1 (el) | 2012-12-14 | 2020-11-02 | Συνθεσεις γαμμα-υδροξυβουτυρικου και η χρηση τους για την αντιμετωπιση διαταραχων |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20201101030T CY1123498T1 (el) | 2012-12-14 | 2020-11-02 | Συνθεσεις γαμμα-υδροξυβουτυρικου και η χρηση τους για την αντιμετωπιση διαταραχων |
Country Status (26)
| Country | Link |
|---|---|
| US (9) | US8591922B1 (el) |
| EP (3) | EP3335709B1 (el) |
| JP (1) | JP6215347B2 (el) |
| KR (1) | KR102180343B1 (el) |
| CN (1) | CN105025892B (el) |
| AU (1) | AU2013359114B2 (el) |
| BR (1) | BR112015014007A2 (el) |
| CA (1) | CA2894876C (el) |
| CY (2) | CY1119918T1 (el) |
| DK (2) | DK2931268T3 (el) |
| ES (2) | ES2827005T3 (el) |
| HK (1) | HK1215181A1 (el) |
| HR (1) | HRP20201685T1 (el) |
| HU (1) | HUE051060T2 (el) |
| IL (1) | IL239355A (el) |
| IN (1) | IN342829B (el) |
| LT (1) | LT3335709T (el) |
| MX (1) | MX366681B (el) |
| NO (1) | NO3027826T3 (el) |
| PL (1) | PL2931268T3 (el) |
| PT (2) | PT2931268T (el) |
| SG (1) | SG11201504637TA (el) |
| SI (1) | SI3335709T1 (el) |
| TR (1) | TR201802271T4 (el) |
| TW (2) | TWI681770B (el) |
| WO (1) | WO2014093791A1 (el) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2794171C (en) | 2010-03-24 | 2018-07-03 | Jazz Pharmaceuticals, Inc. | Controlled release dosage forms for high dose, water soluble and hygroscopic drug substances |
| US8591922B1 (en) | 2012-12-14 | 2013-11-26 | Jazz Pharmacuticals, Inc. | Gamma-hydroxybutyrate compositions and their use for the treatment of disorders |
| US9050302B2 (en) | 2013-03-01 | 2015-06-09 | Jazz Pharmaceuticals Ireland Limited | Method of administration of gamma hydroxybutyrate with monocarboxylate transporters |
| US10398662B1 (en) | 2015-02-18 | 2019-09-03 | Jazz Pharma Ireland Limited | GHB formulation and method for its manufacture |
| AU2016328150B2 (en) | 2015-09-23 | 2020-10-01 | Xw Laboratories Inc. | Prodrugs of gamma-hydroxybutyric acid, compositions and uses thereof |
| FR3049463B1 (fr) | 2016-04-01 | 2019-07-05 | Debregeas Et Associes Pharma | Doses unitaires a liberation immediate de ghb ou de l'un de ses sels therapeutiquement acceptables administrees par voie orale et leur utilisation pour maintenir l'abstinence alcoolique |
| US11000498B2 (en) | 2016-07-22 | 2021-05-11 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11602513B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| UY37341A (es) | 2016-07-22 | 2017-11-30 | Flamel Ireland Ltd | Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada |
| US11986451B1 (en) | 2016-07-22 | 2024-05-21 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11602512B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11504347B1 (en) | 2016-07-22 | 2022-11-22 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US20180263936A1 (en) * | 2017-03-17 | 2018-09-20 | Jazz Pharmaceuticals Ireland Limited | Gamma-hydroxybutyrate compositions and their use for the treatment of disorders |
| US11337920B2 (en) | 2017-12-18 | 2022-05-24 | Tris Pharma, Inc. | Pharmaceutical composition comprising GHB gastro-retentive raft forming systems having trigger pulse drug release |
| EP3740189A1 (en) | 2017-12-18 | 2020-11-25 | Tris Pharma, Inc. | Modified release drug powder composition comprising gastro-retentive raft forming systems having trigger pulse drug release |
| WO2019126215A1 (en) * | 2017-12-18 | 2019-06-27 | Tris Pharma, Inc. | Ghb pharmaceutical compositions comprising a floating interpenetrating polymer network forming system |
| JP7472116B2 (ja) | 2018-11-19 | 2024-04-22 | ジャズ ファーマシューティカルズ アイルランド リミテッド | 耐アルコール性製剤 |
| CN113473980A (zh) | 2019-03-01 | 2021-10-01 | 弗拉梅尔爱尔兰有限公司 | 在进食状态下具有改善的药代动力学的γ-羟基丁酸酯组合物 |
| AU2020414694A1 (en) * | 2019-12-24 | 2022-08-18 | Jazz Pharmaceuticals Ireland Limited | Gamma-hydroxybutyrate (GHB) dosing |
| TW202139986A (zh) | 2020-02-21 | 2021-11-01 | 愛爾蘭商爵士製藥愛爾蘭有限責任公司 | 治療原發性嗜睡症之方法 |
| CN116261451A (zh) | 2020-07-24 | 2023-06-13 | 凯瑞康宁生物工程有限公司 | γ-羟基丁酸衍生物的药物组合物和药物动力学 |
| JP2023544420A (ja) | 2020-10-05 | 2023-10-23 | エックスダブリューファーマ リミテッド | ガンマ－ヒドロキシ酪酸誘導体の調節放出組成物 |
| WO2022076824A1 (en) | 2020-10-08 | 2022-04-14 | Jazz Pharmaceuticals Ireland Limited | Sodium oxybate to treat idiopathic hypersomnia |
| EP4228620A2 (en) | 2020-10-16 | 2023-08-23 | Jazz Pharmaceuticals Ireland Limited | Treatment methods using ghb |
| JP2024511991A (ja) | 2021-03-19 | 2024-03-18 | エックスダブリューファーマ リミテッド | ガンマ－ヒドロキシ酪酸誘導体の組み合わされた放出製剤の薬物動態 |
| WO2022201187A1 (en) * | 2021-03-20 | 2022-09-29 | Alkem Laboratories Limited | A process for the preparation of mixed oxybate salts and polymorphs thereof |
| US11877992B1 (en) | 2021-06-07 | 2024-01-23 | Kelly Kathleen Spinelli | Gamma-hydroxybutyrate salts for the treatment of learning disorders |
| US11877993B1 (en) | 2021-06-23 | 2024-01-23 | Kelly Kathleen Spinelli | Gamma-hydroxybutyrate salts for the treatment of psychological disorders |
| WO2023062018A1 (en) | 2021-10-11 | 2023-04-20 | Jazz Pharmaceuticals Ireland Limited | Method of administering oxybate |
| WO2023135150A1 (en) | 2022-01-11 | 2023-07-20 | Jazz Pharmaceuticals Ireland Limited | Method of administering oxybate |
| US11779557B1 (en) | 2022-02-07 | 2023-10-10 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11583510B1 (en) | 2022-02-07 | 2023-02-21 | Flamel Ireland Limited | Methods of administering gamma hydroxybutyrate formulations after a high-fat meal |
| WO2023205241A1 (en) * | 2022-04-21 | 2023-10-26 | Zevra Therapeutics, Inc. | Gamma-hydroxybutyrate delivering compounds and processes for making and using them |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB922029A (en) | 1960-05-19 | 1963-03-27 | Equilibre Biolog L | Therapeutic composition |
| US4374441A (en) | 1980-05-23 | 1983-02-22 | Book Covers, Inc. | Method of making a book cover and pocket element therefor |
| ZA814854B (en) | 1980-07-17 | 1982-07-28 | J Klosa | Nonhygroscopic salts of 4-hydroxybutryric acid, methods of their production and pharmaceutical preparations containing these salts |
| EP0044801B1 (de) | 1980-07-17 | 1984-02-15 | Josef Dr. Klosa | Nichthygroskopische Salze der 4-Hydroxybuttersäure, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Mittel |
| EP0235408B1 (en) | 1984-08-06 | 1991-01-09 | The University Of Toronto Innovations Foundation | Pharmaceutical composition and treatment |
| US4738985A (en) | 1986-03-19 | 1988-04-19 | The University Of Toronto Innovations Foundations | Pharmaceutical composition and treatment |
| IT1217783B (it) | 1988-06-03 | 1990-03-30 | Farmaceutico Ct S R L Lab | Impiego di salo dell,acido gamma idrossi butirrico per la preparazione di composizioni farmaceutiche adatta ad essereimpiegate nella terapia dell,alcolismo e composizioni relative |
| JP2564690B2 (ja) | 1990-06-14 | 1996-12-18 | 三省製薬 株式会社 | メラニン生成抑制外用剤 |
| DE4113984C2 (de) | 1991-04-29 | 2002-05-08 | Koehler Chemie Dr Franz | Salze der 4-Hydroxy-Buttersäure |
| IT1271403B (it) | 1993-03-26 | 1997-05-28 | Ct Lab Farm Srl | Sali dell'acido gamma-idrossibutirrico ad attivita' ansiolitica e per il trattamento degli stati depressivi |
| IT1266565B1 (it) | 1993-07-22 | 1997-01-09 | Ct Lab Farm Srl | Composizioni farmaceutiche a rilascio controllato a base di uno o piu' sali farmaceuticamente accettabili dell'acido gamma-idrossi-butirrico. |
| US5840331A (en) | 1995-06-07 | 1998-11-24 | Arch Development Corporation | Use of γ-hydroxybutyrate for the stimulation of sleep-related secretion growth hormone and prolactin |
| IT1283782B1 (it) | 1996-08-09 | 1998-04-30 | Ct Lab Farm Srl | Uso di ammidi dell'acido gamma-idrossibutirrico nel trattamento di tossicodipendenze,ed in particolare sell'alcolismo |
| US6495598B1 (en) | 1997-04-22 | 2002-12-17 | Ophtecs Corporation | Perfusate preparation for ophthalmic operation |
| US5990162A (en) | 1997-08-29 | 1999-11-23 | Orphan Medical, Inc. | Method for treatment of fibromyalgia and chronic fatigue syndrome |
| AU779354B2 (en) | 1998-12-23 | 2005-01-20 | Orphan Medical, Inc. | Microbiologically sound and stable solutions of gamma-hydroxybutyrate salt for the treatment of narcolepsy |
| CA2423358C (en) | 2000-09-22 | 2011-05-17 | Orphan Medical, Inc. | Gamma-hydroxybutyrate compositions containing carbohydrate, lipid or amino acid carriers |
| FR2817256B1 (fr) | 2000-11-27 | 2005-07-15 | Univ Pasteur | Derives de l'acides 4-hydroxybutanoique et de son homologue superieur comme ligands des recepteurs du gamma- hydroxybutyrate (ghb), compositions pharmaceutiques les contenant et utilisations pharmaceutiques |
| WO2006124609A2 (en) * | 2005-05-16 | 2006-11-23 | Joseph Johnson | Methods and compositions for treating arg |
| US8771735B2 (en) | 2008-11-04 | 2014-07-08 | Jazz Pharmaceuticals, Inc. | Immediate release dosage forms of sodium oxybate |
| US8778398B2 (en) | 2008-11-04 | 2014-07-15 | Jazz Pharmaceuticals, Inc. | Immediate release formulations and dosage forms of gamma-hydroxybutyrate |
| US8410304B2 (en) | 2009-04-15 | 2013-04-02 | Norac Pharma | Process for preparing gamma-hydroxybutyrate |
| BR112012028035B1 (pt) * | 2010-05-04 | 2021-05-25 | Jazz Pharmaceuticals, Inc. | formulação de liberação imediata |
| US8591922B1 (en) | 2012-12-14 | 2013-11-26 | Jazz Pharmacuticals, Inc. | Gamma-hydroxybutyrate compositions and their use for the treatment of disorders |
| US9050302B2 (en) | 2013-03-01 | 2015-06-09 | Jazz Pharmaceuticals Ireland Limited | Method of administration of gamma hydroxybutyrate with monocarboxylate transporters |
| US20180263936A1 (en) | 2017-03-17 | 2018-09-20 | Jazz Pharmaceuticals Ireland Limited | Gamma-hydroxybutyrate compositions and their use for the treatment of disorders |
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2013
- 2013-01-11 US US13/739,886 patent/US8591922B1/en active Active
- 2013-10-03 US US14/045,673 patent/US9132107B2/en active Active
- 2013-12-13 LT LTEP17202548.8T patent/LT3335709T/lt unknown
- 2013-12-13 PL PL13863231T patent/PL2931268T3/pl unknown
- 2013-12-13 TR TR2018/02271T patent/TR201802271T4/tr unknown
- 2013-12-13 PT PT138632310T patent/PT2931268T/pt unknown
- 2013-12-13 TW TW106143923A patent/TWI681770B/zh active
- 2013-12-13 JP JP2015547980A patent/JP6215347B2/ja active Active
- 2013-12-13 CA CA2894876A patent/CA2894876C/en active Active
- 2013-12-13 DK DK13863231.0T patent/DK2931268T3/en active
- 2013-12-13 AU AU2013359114A patent/AU2013359114B2/en active Active
- 2013-12-13 ES ES17202548T patent/ES2827005T3/es active Active
- 2013-12-13 EP EP17202548.8A patent/EP3335709B1/en active Active
- 2013-12-13 PT PT172025488T patent/PT3335709T/pt unknown
- 2013-12-13 HU HUE17202548A patent/HUE051060T2/hu unknown
- 2013-12-13 SI SI201331802T patent/SI3335709T1/sl unknown
- 2013-12-13 BR BR112015014007A patent/BR112015014007A2/pt active Search and Examination
- 2013-12-13 EP EP13863231.0A patent/EP2931268B1/en active Active
- 2013-12-13 WO PCT/US2013/074954 patent/WO2014093791A1/en active Application Filing
- 2013-12-13 DK DK17202548.8T patent/DK3335709T3/da active
- 2013-12-13 MX MX2015007531A patent/MX366681B/es active IP Right Grant
- 2013-12-13 KR KR1020157018947A patent/KR102180343B1/ko active IP Right Grant
- 2013-12-13 ES ES13863231.0T patent/ES2660056T3/es active Active
- 2013-12-13 CN CN201380072864.8A patent/CN105025892B/zh active Active
- 2013-12-13 TW TW102146274A patent/TWI639425B/zh active
- 2013-12-13 EP EP20190343.2A patent/EP3799867A1/en active Pending
- 2013-12-13 SG SG11201504637TA patent/SG11201504637TA/en unknown
- 2013-12-13 IN IN3943CH2015 patent/IN342829B/en unknown
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2014
- 2014-02-04 US US14/172,751 patent/US8901173B2/en active Active
- 2014-07-22 NO NO14741895A patent/NO3027826T3/no unknown
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2015
- 2015-06-11 IL IL239355A patent/IL239355A/en active IP Right Grant
- 2015-08-07 US US14/821,384 patent/US9555017B2/en active Active
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2016
- 2016-03-18 HK HK16103210.0A patent/HK1215181A1/zh unknown
- 2016-12-20 US US15/385,447 patent/US10195168B2/en active Active
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2018
- 2018-02-14 CY CY20181100181T patent/CY1119918T1/el unknown
- 2018-12-21 US US16/230,460 patent/US10675258B2/en active Active
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2020
- 2020-05-12 US US15/930,295 patent/US11554102B2/en active Active
- 2020-10-19 HR HRP20201685TT patent/HRP20201685T1/hr unknown
- 2020-11-02 CY CY20201101030T patent/CY1123498T1/el unknown
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2021
- 2021-09-20 US US17/479,886 patent/US20220000815A1/en not_active Abandoned
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2023
- 2023-06-30 US US18/346,015 patent/US20240156759A1/en active Pending
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