CY1119762T1 - C-17-ετεροαρυλικα παραγωγα ελαιολικου οξεος και μεθοδοι χρησης αυτων - Google Patents
C-17-ετεροαρυλικα παραγωγα ελαιολικου οξεος και μεθοδοι χρησης αυτωνInfo
- Publication number
- CY1119762T1 CY1119762T1 CY20171101157T CY171101157T CY1119762T1 CY 1119762 T1 CY1119762 T1 CY 1119762T1 CY 20171101157 T CY20171101157 T CY 20171101157T CY 171101157 T CY171101157 T CY 171101157T CY 1119762 T1 CY1119762 T1 CY 1119762T1
- Authority
- CY
- Cyprus
- Prior art keywords
- methods
- oleic acid
- hetero
- aryl derivatives
- compounds
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 title abstract 2
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 title abstract 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 title abstract 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 title abstract 2
- 239000005642 Oleic acid Substances 0.000 title abstract 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Lubricants (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Epidemiology (AREA)
Abstract
Στο παρόν γνωστοποιούνται νέα C17-ετεροαρυλικά παράγωγα ελαιολικού οξέος, συμπεριλαμβανομένων εκείνων του τύπου (I): όπου οι μεταβλητές ορίζονται στο παρόν. Παρέχονται επίσης φαρμακευτικές συνθέσεις, κιτ και αντικείμενα παρασκευής που περιλαμβάνουν τέτοιες ενώσεις. Παρέχονται επίσης μέθοδοι και ενδιάμεσα προϊόντα που είναι χρήσιμα για τη δημιουργία των ενώσεων, και μέθοδοι χρήσης των ενώσεων, για παράδειγμα, ως αντιοξειδωτικών ρυθμιστών φλεγμονής, και συνθέσεις αυτών.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261699199P | 2012-09-10 | 2012-09-10 | |
PCT/US2013/059015 WO2014040056A1 (en) | 2012-09-10 | 2013-09-10 | C17-heteroaryl derivatives of oleanolic acid and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1119762T1 true CY1119762T1 (el) | 2018-06-27 |
Family
ID=49253401
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20171101157T CY1119762T1 (el) | 2012-09-10 | 2017-11-03 | C-17-ετεροαρυλικα παραγωγα ελαιολικου οξεος και μεθοδοι χρησης αυτων |
Country Status (28)
Country | Link |
---|---|
US (1) | US20140088163A1 (el) |
EP (1) | EP2892911B1 (el) |
JP (1) | JP6272870B2 (el) |
KR (1) | KR102237364B1 (el) |
CN (1) | CN104768965B (el) |
AU (1) | AU2013312102B2 (el) |
BR (1) | BR112015005200B1 (el) |
CA (1) | CA2882417C (el) |
CY (1) | CY1119762T1 (el) |
DK (1) | DK2892911T3 (el) |
EA (1) | EA029069B1 (el) |
ES (1) | ES2644615T3 (el) |
HK (1) | HK1211295A1 (el) |
HR (1) | HRP20171565T1 (el) |
HU (1) | HUE036797T2 (el) |
IL (1) | IL237638B (el) |
IN (1) | IN2015DN01547A (el) |
LT (1) | LT2892911T (el) |
ME (1) | ME02911B (el) |
MX (1) | MX366954B (el) |
NZ (1) | NZ705213A (el) |
PL (1) | PL2892911T3 (el) |
PT (1) | PT2892911T (el) |
RS (1) | RS56563B1 (el) |
SG (1) | SG11201501800UA (el) |
SI (1) | SI2892911T1 (el) |
WO (1) | WO2014040056A1 (el) |
ZA (1) | ZA201501203B (el) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI492745B (zh) | 2008-01-11 | 2015-07-21 | Reata Pharmaceuticals Inc | 合成的三萜系化合物及其使用於治療疾病之方法 |
HUE041221T2 (hu) | 2008-04-18 | 2019-05-28 | Reata Pharmaceuticals Inc | Antioxidáns gyulladás modulátorok: a C-17 atomon amino- és más módosításokkal rendelkezõ oleanolsav-származékok |
US8258329B2 (en) | 2008-04-18 | 2012-09-04 | Reata Pharmaceuticals, Inc. | Dehydroandrosterone analogs including an anti-inflammatory pharmacore and methods of use |
KR102000301B1 (ko) | 2010-12-17 | 2019-07-15 | 리아타 파마슈티컬즈, 아이엔씨. | 산화방지성 염증 조절제로서의 피라졸릴 및 피리미디닐 트리사이클릭 엔온 |
EA030468B1 (ru) | 2012-04-27 | 2018-08-31 | Рита Фармасьютикалз, Инк. | 2,2-дифторпропионамидные производные бардоксолон-метила, их полиморфные формы и способы применения |
US9556222B2 (en) | 2012-06-15 | 2017-01-31 | Reata Pharmaceuticals, Inc. | A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof |
CN104955833B (zh) | 2012-09-10 | 2019-10-11 | 里亚塔医药公司 | 齐墩果酸的c17-烷二基与烯二基衍生物及其使用方法 |
US9512094B2 (en) | 2012-09-10 | 2016-12-06 | Reata Pharmaceuticals, Inc. | C17-heteroaryl derivatives of oleanolic acid and methods of use thereof |
TWI649330B (zh) | 2013-04-24 | 2019-02-01 | 艾伯維有限公司 | 甲基巴多索龍之2,2-二氟丙醯胺衍生物、其多晶形及其使用方法 |
NZ734292A (en) | 2015-02-12 | 2022-09-30 | Reata Pharmaceuticals Inc | Imidazolyl tricyclic enones as antioxidant inflammation modulators |
US11584775B2 (en) | 2015-09-23 | 2023-02-21 | Reata Pharmaceuticals, Inc. | C4-modified oleanolic acid derivatives for inhibition of IL-17 and other uses |
KR102486434B1 (ko) | 2016-11-08 | 2023-01-09 | 리아타 파마슈티컬즈 홀딩스, 엘엘씨 | 바독솔론 메틸 또는 이의 유사체를 사용하는 알포트 증후군의 치료 방법 |
CN106632574B (zh) * | 2016-12-07 | 2018-05-29 | 广东天键生物科技有限公司 | 一种化合物、其制备方法及用途 |
TWI831738B (zh) | 2016-12-16 | 2024-02-11 | 美商瑞塔醫藥有限責任公司 | 用於抑制RORγ及其他用途的嘧啶三環烯酮衍生物 |
RU2020113341A (ru) | 2017-09-14 | 2021-10-15 | Феникс Байотекнолоджи, Инк. | Способ и композиция для лечения вирусной инфекции |
EP3681477A4 (en) | 2017-09-14 | 2021-06-09 | Phoenix Biotechnology, Inc. | IMPROVED METHOD AND COMPOSITION FOR THE TREATMENT OF CONDITIONS, DISEASES OR DISORDERS SENSITIVE TO TRITERPENES |
BR112020025605A2 (pt) | 2018-06-15 | 2021-03-23 | Reata Pharmaceuticals, Inc. | compostos de pirazol e imidazol para inibição de il-17 e rorgama |
BR112021005919A2 (pt) * | 2018-09-28 | 2021-07-27 | Sichuan Haisco Pharmaceutical Co., Ltd. | composto, composição farmacêutica e método para tratar uma doença em um mamífero |
KR20220044942A (ko) * | 2019-07-19 | 2022-04-12 | 리아타 파마슈티컬즈, 아이엔씨. | C17 극성-치환된 헤테로방향족 합성 트리터페노이드 및 그의 사용 방법 |
KR102464428B1 (ko) | 2020-03-31 | 2022-11-04 | 피닉스 바이오테크놀러지 인코포레이티드. | 코로나바이러스 감염 치료를 위한 방법 및 조성물 |
EP4295854A3 (en) | 2020-03-31 | 2024-04-03 | Phoenix Biotechnology, Inc. | Method and compositions for treating coronavirus infection |
JP7214696B2 (ja) * | 2020-10-01 | 2023-01-30 | 一般財団法人 化学物質評価研究機構 | 新規in vitro皮膚感作性試験法 |
AU2021397631A1 (en) | 2020-12-11 | 2023-07-20 | Reata Pharmaceuticals Holdings, LLC | Synthetic triterpenoids for use in therapy |
CN117015548A (zh) | 2021-01-18 | 2023-11-07 | 里亚塔医药公司 | 合成的熊果酸衍生物和其使用方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6326507B1 (en) * | 1998-06-19 | 2001-12-04 | Trustees Of Dartmouth College | Therapeutic compounds and methods of use |
WO2004064723A2 (en) * | 2002-05-13 | 2004-08-05 | Trustees Of Dartmouth College | Inhibitors and methods of use thereof |
TWI492745B (zh) | 2008-01-11 | 2015-07-21 | Reata Pharmaceuticals Inc | 合成的三萜系化合物及其使用於治療疾病之方法 |
TW201004627A (en) | 2008-04-18 | 2010-02-01 | Reata Pharmaceuticals Inc | Antioxidant inflammation modulators: novel derivatives of oleanolic acid |
TWI584808B (zh) * | 2008-04-18 | 2017-06-01 | 瑞塔醫藥有限責任公司 | 抗氧化發炎調節劑:c-17同系齊墩果酸衍生物 |
HUE041221T2 (hu) | 2008-04-18 | 2019-05-28 | Reata Pharmaceuticals Inc | Antioxidáns gyulladás modulátorok: a C-17 atomon amino- és más módosításokkal rendelkezõ oleanolsav-származékok |
JP5529850B2 (ja) | 2008-04-18 | 2014-06-25 | リアタ ファーマシューティカルズ インコーポレイテッド | 抗酸化炎症モジュレーター:c環中に飽和を有するオレアノール酸誘導体 |
RS59200B1 (sr) * | 2011-03-11 | 2019-10-31 | Reata Pharmaceuticals Inc | Derivati c4-monometil triterpenoida i postupci za njihovu upotrebu |
US9556222B2 (en) * | 2012-06-15 | 2017-01-31 | Reata Pharmaceuticals, Inc. | A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof |
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2013
- 2013-09-10 JP JP2015531317A patent/JP6272870B2/ja active Active
- 2013-09-10 IN IN1547DEN2015 patent/IN2015DN01547A/en unknown
- 2013-09-10 CN CN201380057684.2A patent/CN104768965B/zh active Active
- 2013-09-10 WO PCT/US2013/059015 patent/WO2014040056A1/en active Application Filing
- 2013-09-10 NZ NZ705213A patent/NZ705213A/en unknown
- 2013-09-10 AU AU2013312102A patent/AU2013312102B2/en active Active
- 2013-09-10 DK DK13767175.6T patent/DK2892911T3/en active
- 2013-09-10 ES ES13767175.6T patent/ES2644615T3/es active Active
- 2013-09-10 KR KR1020157009160A patent/KR102237364B1/ko active IP Right Grant
- 2013-09-10 US US14/022,843 patent/US20140088163A1/en not_active Abandoned
- 2013-09-10 HU HUE13767175A patent/HUE036797T2/hu unknown
- 2013-09-10 RS RS20171140A patent/RS56563B1/sr unknown
- 2013-09-10 PT PT137671756T patent/PT2892911T/pt unknown
- 2013-09-10 SI SI201330818T patent/SI2892911T1/sl unknown
- 2013-09-10 ME MEP-2017-254A patent/ME02911B/me unknown
- 2013-09-10 CA CA2882417A patent/CA2882417C/en active Active
- 2013-09-10 BR BR112015005200-2A patent/BR112015005200B1/pt active IP Right Grant
- 2013-09-10 EP EP13767175.6A patent/EP2892911B1/en active Active
- 2013-09-10 PL PL13767175T patent/PL2892911T3/pl unknown
- 2013-09-10 EA EA201590539A patent/EA029069B1/ru unknown
- 2013-09-10 LT LTEP13767175.6T patent/LT2892911T/lt unknown
- 2013-09-10 MX MX2015003078A patent/MX366954B/es active IP Right Grant
- 2013-09-10 SG SG11201501800UA patent/SG11201501800UA/en unknown
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2015
- 2015-02-23 ZA ZA2015/01203A patent/ZA201501203B/en unknown
- 2015-03-09 IL IL237638A patent/IL237638B/en active IP Right Grant
- 2015-12-07 HK HK15112022.0A patent/HK1211295A1/xx unknown
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2017
- 2017-10-16 HR HRP20171565TT patent/HRP20171565T1/hr unknown
- 2017-11-03 CY CY20171101157T patent/CY1119762T1/el unknown
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