CY1117319T1 - Τρικυκλικα παραγωγα αμινης ως αναστολεις πρωτεϊνικης τυροσινης κινασης - Google Patents
Τρικυκλικα παραγωγα αμινης ως αναστολεις πρωτεϊνικης τυροσινης κινασηςInfo
- Publication number
- CY1117319T1 CY1117319T1 CY20161100015T CY161100015T CY1117319T1 CY 1117319 T1 CY1117319 T1 CY 1117319T1 CY 20161100015 T CY20161100015 T CY 20161100015T CY 161100015 T CY161100015 T CY 161100015T CY 1117319 T1 CY1117319 T1 CY 1117319T1
- Authority
- CY
- Cyprus
- Prior art keywords
- tysine
- inspectors
- amin
- tricyclic
- muscle
- Prior art date
Links
- 210000003205 muscle Anatomy 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 108091008794 FGF receptors Proteins 0.000 abstract 1
- 101000692455 Homo sapiens Platelet-derived growth factor receptor beta Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102100026547 Platelet-derived growth factor receptor beta Human genes 0.000 abstract 1
- 108091008605 VEGF receptors Proteins 0.000 abstract 1
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 abstract 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 102000052178 fibroblast growth factor receptor activity proteins Human genes 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Η εφεύρεση αναφέρεται σε νέες ενώσεις δικυκλικών ετεροκυκλυλικών παραγώγων του τύπου I, σε φαρμακευτικές συνθέσεις που περιλαμβάνουν τις εν λόγω ενώσεις και στη χρήση των εν λόγω ενώσεων στη θεραπεία ασθενειών, π.χ. του καρκίνου. Οι ενώσεις του τύπου I είναι αναστολείς των FGFR, VEGFR ή PDGFR.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87153806P | 2006-12-22 | 2006-12-22 | |
GB0625827A GB0625827D0 (en) | 2006-12-22 | 2006-12-22 | New compounds |
US97958207P | 2007-10-12 | 2007-10-12 | |
GB0719998A GB0719998D0 (en) | 2007-10-12 | 2007-10-12 | New compounds |
EP07848681.8A EP2121687B1 (en) | 2006-12-22 | 2007-12-21 | Tricyclic amine derivatives as protein tyrosine kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1117319T1 true CY1117319T1 (el) | 2017-04-26 |
Family
ID=39322759
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20161100015T CY1117319T1 (el) | 2006-12-22 | 2016-01-11 | Τρικυκλικα παραγωγα αμινης ως αναστολεις πρωτεϊνικης τυροσινης κινασης |
Country Status (12)
Country | Link |
---|---|
US (1) | US8513276B2 (el) |
EP (1) | EP2121687B1 (el) |
JP (1) | JP5442449B2 (el) |
CN (1) | CN101679409B (el) |
AU (1) | AU2007337895C1 (el) |
CA (1) | CA2672213C (el) |
CY (1) | CY1117319T1 (el) |
HR (1) | HRP20151398T1 (el) |
MX (1) | MX2009006704A (el) |
NO (1) | NO342865B1 (el) |
PL (1) | PL2121687T3 (el) |
WO (1) | WO2008078100A2 (el) |
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WO2008078091A1 (en) * | 2006-12-22 | 2008-07-03 | Astex Therapeutics Limited | Bicyclic heterocyclic compounds as fgfr inhibitors |
CA2672213C (en) | 2006-12-22 | 2016-02-16 | Astex Therapeutics Limited | Bicyclic amine derivatives as protein tyrosine kinase inhibitors |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
TW200922566A (en) | 2007-09-14 | 2009-06-01 | Ortho Mcneil Janssen Pharm | 1,3 disubstituted 4-(aryl-X-phenyl)-1H-pyridin-2-ones |
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GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
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US8486940B2 (en) | 2009-09-11 | 2013-07-16 | Probiodrug Ag | Inhibitors |
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- 2007-12-21 CA CA2672213A patent/CA2672213C/en active Active
- 2007-12-21 PL PL07848681T patent/PL2121687T3/pl unknown
- 2007-12-21 JP JP2009542227A patent/JP5442449B2/ja active Active
- 2007-12-21 CN CN200780047742.8A patent/CN101679409B/zh active Active
- 2007-12-21 US US12/520,333 patent/US8513276B2/en active Active
- 2007-12-21 AU AU2007337895A patent/AU2007337895C1/en active Active
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- 2007-12-21 WO PCT/GB2007/004960 patent/WO2008078100A2/en active Application Filing
- 2007-12-21 EP EP07848681.8A patent/EP2121687B1/en active Active
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US20100093718A1 (en) | 2010-04-15 |
WO2008078100A3 (en) | 2008-11-13 |
EP2121687B1 (en) | 2015-10-14 |
JP2010513448A (ja) | 2010-04-30 |
CN101679409B (zh) | 2014-11-26 |
WO2008078100A2 (en) | 2008-07-03 |
PL2121687T3 (pl) | 2016-03-31 |
CA2672213A1 (en) | 2008-07-03 |
AU2007337895C1 (en) | 2014-07-31 |
HRP20151398T1 (hr) | 2016-02-12 |
CA2672213C (en) | 2016-02-16 |
EP2121687A2 (en) | 2009-11-25 |
AU2007337895B2 (en) | 2014-01-30 |
JP5442449B2 (ja) | 2014-03-12 |
NO342865B1 (no) | 2018-08-20 |
AU2007337895A1 (en) | 2008-07-03 |
CN101679409A (zh) | 2010-03-24 |
NO20092658L (no) | 2009-09-17 |
MX2009006704A (es) | 2009-06-30 |
US8513276B2 (en) | 2013-08-20 |
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