CY1116480T1 - Βακτηριακο στελεχος ξενιστη που περιεχει ενα μεταλλαγμενο spr γονιδιο και μειωμενη δραση tsp - Google Patents
Βακτηριακο στελεχος ξενιστη που περιεχει ενα μεταλλαγμενο spr γονιδιο και μειωμενη δραση tspInfo
- Publication number
- CY1116480T1 CY1116480T1 CY20151100525T CY151100525T CY1116480T1 CY 1116480 T1 CY1116480 T1 CY 1116480T1 CY 20151100525 T CY20151100525 T CY 20151100525T CY 151100525 T CY151100525 T CY 151100525T CY 1116480 T1 CY1116480 T1 CY 1116480T1
- Authority
- CY
- Cyprus
- Prior art keywords
- bacterial host
- host strain
- strain containing
- spr gene
- mutant spr
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
Η παρούσα εφεύρεση παρέχει ένα ανασυνδυασμένο gram-αρνητικό βακτηριακό κύτταρο, το οποίο περιέχει ένα μεταλλαγμένο spr γονίδιο, το οποίο κωδικοποιεί μια spr πρωτεΐνη, το οποίο έχει μια μετάλλαξη σε ένα ή περισσότερα από τα αμινοξέα D133, Η145, Η157, Ν31, R62, 170, Q73, C94, S95, V98, Q99, R100, L108, Υ115, V135, L136, G140, R144 και G147 και όπου το κύτταρο έχει μειωμένη λειτουργία πρωτεΐνης Tsp συγκριτικά με την αντίστοιχη ενός άγριου τύπου κυττάρου.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1000587.4A GB201000587D0 (en) | 2010-01-14 | 2010-01-14 | Bacterial hoist strain |
PCT/EP2011/050413 WO2011086136A1 (en) | 2010-01-14 | 2011-01-13 | Bacterial host strain comprising a mutant spr gene and having reduced tsp activity |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1116480T1 true CY1116480T1 (el) | 2018-03-07 |
Family
ID=42028357
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20151100525T CY1116480T1 (el) | 2010-01-14 | 2015-06-18 | Βακτηριακο στελεχος ξενιστη που περιεχει ενα μεταλλαγμενο spr γονιδιο και μειωμενη δραση tsp |
Country Status (21)
Country | Link |
---|---|
US (2) | US8969039B2 (el) |
EP (1) | EP2524043B1 (el) |
JP (1) | JP5896569B2 (el) |
KR (1) | KR101737152B1 (el) |
CN (2) | CN102762732B (el) |
AU (1) | AU2011206584B2 (el) |
BR (1) | BR112012017425A2 (el) |
CA (1) | CA2786335C (el) |
CY (1) | CY1116480T1 (el) |
DK (1) | DK2524043T3 (el) |
ES (1) | ES2539931T3 (el) |
GB (1) | GB201000587D0 (el) |
HK (1) | HK1177760A1 (el) |
HR (1) | HRP20150659T1 (el) |
PL (1) | PL2524043T3 (el) |
PT (1) | PT2524043E (el) |
RS (1) | RS54084B1 (el) |
SG (1) | SG182301A1 (el) |
SI (1) | SI2524043T1 (el) |
SM (1) | SMT201500145B (el) |
WO (1) | WO2011086136A1 (el) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101758942B1 (ko) | 2009-09-24 | 2017-07-17 | 유씨비 파마, 에스.에이. | 박테리아 숙주 균주 |
GB201000587D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial hoist strain |
GB201000591D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial hoist strain |
GB201000590D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial host strain |
GB201012599D0 (en) | 2010-07-27 | 2010-09-08 | Ucb Pharma Sa | Process for purifying proteins |
EP3339325A1 (en) * | 2011-07-13 | 2018-06-27 | UCB Biopharma SPRL | Bacterial host strain expressing recombinant dsbc |
GB201208370D0 (en) | 2012-05-14 | 2012-06-27 | Ucb Pharma Sa | Antibodies |
GB201208367D0 (en) * | 2012-05-14 | 2012-06-27 | Ucb Pharma Sa | Biological product |
EP4253548A3 (en) | 2014-12-22 | 2024-01-03 | UCB Biopharma SRL | Protein manufacture |
TW201702380A (zh) * | 2015-02-27 | 2017-01-16 | 再生元醫藥公司 | 宿主細胞蛋白質修飾 |
BR112018015259A2 (pt) | 2016-01-27 | 2018-12-18 | Medimmune Llc | métodos para preparação de anticorpos com um padrão de glicosilação definido |
AU2020243460A1 (en) | 2019-03-18 | 2021-10-07 | Bio-Rad Abd Serotec Gmbh | Protection of SpyTag-containing periplasmic fusion proteins from protease Tsp and ompT degradation |
CN114829578A (zh) * | 2019-08-05 | 2022-07-29 | 瓦克化学股份公司 | 用于在发酵方法中释放重组蛋白的细菌菌株 |
CN113462666B (zh) * | 2021-08-18 | 2023-04-07 | 杭州文德阶生物科技有限公司 | 羰基还原酶突变体及其应用 |
SE545714C2 (en) * | 2021-09-24 | 2023-12-19 | Xbrane Biopharma Ab | Dna contructs for producing a pelb signal peptide |
SE545694C2 (en) * | 2021-09-24 | 2023-12-05 | Xbrane Biopharma Ab | Dna construct comprising nucleotide sequences encoding amino acid sequences of certolizumab and pelb signal peptides |
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GB201000591D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial hoist strain |
GB201000590D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial host strain |
GB201000588D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial host strain |
GB201000587D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial hoist strain |
GB201001791D0 (en) | 2010-02-03 | 2010-03-24 | Ucb Pharma Sa | Process for obtaining antibodies |
GB201012599D0 (en) | 2010-07-27 | 2010-09-08 | Ucb Pharma Sa | Process for purifying proteins |
EP3339325A1 (en) | 2011-07-13 | 2018-06-27 | UCB Biopharma SPRL | Bacterial host strain expressing recombinant dsbc |
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GB201208367D0 (en) | 2012-05-14 | 2012-06-27 | Ucb Pharma Sa | Biological product |
-
2010
- 2010-01-14 GB GBGB1000587.4A patent/GB201000587D0/en not_active Ceased
-
2011
- 2011-01-13 PL PL11701216T patent/PL2524043T3/pl unknown
- 2011-01-13 ES ES11701216.1T patent/ES2539931T3/es active Active
- 2011-01-13 SI SI201130522T patent/SI2524043T1/sl unknown
- 2011-01-13 RS RS20150420A patent/RS54084B1/en unknown
- 2011-01-13 AU AU2011206584A patent/AU2011206584B2/en active Active
- 2011-01-13 JP JP2012548439A patent/JP5896569B2/ja active Active
- 2011-01-13 PT PT117012161T patent/PT2524043E/pt unknown
- 2011-01-13 BR BR112012017425A patent/BR112012017425A2/pt not_active Application Discontinuation
- 2011-01-13 CN CN201180009682.7A patent/CN102762732B/zh active Active
- 2011-01-13 CN CN201510999982.4A patent/CN105505845A/zh active Pending
- 2011-01-13 EP EP11701216.1A patent/EP2524043B1/en active Active
- 2011-01-13 SG SG2012048567A patent/SG182301A1/en unknown
- 2011-01-13 DK DK11701216.1T patent/DK2524043T3/da active
- 2011-01-13 CA CA2786335A patent/CA2786335C/en active Active
- 2011-01-13 KR KR1020127021022A patent/KR101737152B1/ko active IP Right Grant
- 2011-01-13 WO PCT/EP2011/050413 patent/WO2011086136A1/en active Application Filing
- 2011-01-13 US US13/522,087 patent/US8969039B2/en active Active
-
2013
- 2013-04-17 HK HK13104687.5A patent/HK1177760A1/zh unknown
-
2015
- 2015-01-20 US US14/600,089 patent/US9587227B2/en active Active
- 2015-06-17 HR HRP20150659TT patent/HRP20150659T1/hr unknown
- 2015-06-18 CY CY20151100525T patent/CY1116480T1/el unknown
- 2015-06-19 SM SM201500145T patent/SMT201500145B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
US8969039B2 (en) | 2015-03-03 |
SI2524043T1 (sl) | 2015-07-31 |
CN105505845A (zh) | 2016-04-20 |
KR101737152B1 (ko) | 2017-05-17 |
HK1177760A1 (zh) | 2013-08-30 |
KR20130030247A (ko) | 2013-03-26 |
PT2524043E (pt) | 2015-07-22 |
SG182301A1 (en) | 2012-08-30 |
US9587227B2 (en) | 2017-03-07 |
EP2524043B1 (en) | 2015-03-18 |
RS54084B1 (en) | 2015-10-30 |
PL2524043T3 (pl) | 2016-08-31 |
AU2011206584A1 (en) | 2012-07-26 |
GB201000587D0 (en) | 2010-03-03 |
JP5896569B2 (ja) | 2016-03-30 |
EP2524043A1 (en) | 2012-11-21 |
US20150132828A1 (en) | 2015-05-14 |
CA2786335C (en) | 2017-10-10 |
BR112012017425A2 (pt) | 2015-09-15 |
CN102762732B (zh) | 2016-03-09 |
AU2011206584B2 (en) | 2016-06-09 |
SMT201500145B (it) | 2015-09-07 |
JP2013516964A (ja) | 2013-05-16 |
DK2524043T3 (da) | 2015-06-22 |
WO2011086136A1 (en) | 2011-07-21 |
CA2786335A1 (en) | 2011-07-21 |
ES2539931T3 (es) | 2015-07-07 |
CN102762732A (zh) | 2012-10-31 |
US20120295309A1 (en) | 2012-11-22 |
HRP20150659T1 (hr) | 2015-07-31 |
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