CY1116167T1 - Φαρμακευτικeς συνθεσεις κατευθυνομενες σε υποδοχεις erb-b1 - Google Patents
Φαρμακευτικeς συνθεσεις κατευθυνομενες σε υποδοχεις erb-b1Info
- Publication number
- CY1116167T1 CY1116167T1 CY20151100329T CY151100329T CY1116167T1 CY 1116167 T1 CY1116167 T1 CY 1116167T1 CY 20151100329 T CY20151100329 T CY 20151100329T CY 151100329 T CY151100329 T CY 151100329T CY 1116167 T1 CY1116167 T1 CY 1116167T1
- Authority
- CY
- Cyprus
- Prior art keywords
- pharmaceutical compositions
- erb
- guided
- mab
- relates
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
Abstract
Η εφεύρεση αναφέρεται σε φαρμακευτικές συνθέσεις που περιλαμβάνουν διαφορετικά μόρια, κατά προτίμηση μονοκλωνικά αντισώματα, που το καθένα περιλαμβάνει επιτόπους που δεσμεύονται ταυτόχρονα σε διαφορετικές θέσεις εντός της ίδιας περιοχής του υποδοχέα ErbB 1. Τα προτιμώμενα αντισώματα σύμφωνα με αυτή την εφεύρεση είναι τα MAb 425 και MAb 225 καθένα υπό την μυοειδή, χιμαιρική και ανθρωποποιημένη έκδοση. Η εφεύρεση σχετίζεται με τη χρήση και τις μεθόδους για βελτιωμένη θεραπεία κατά προτίμηση όγκων μέσω των εν λόγω συνθέσεων.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02022389 | 2002-10-10 | ||
EP02022390 | 2002-10-10 | ||
EP03757931.5A EP1549344B1 (en) | 2002-10-10 | 2003-10-09 | Pharmaceutical compositions directed to erb-b1 receptors |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1116167T1 true CY1116167T1 (el) | 2017-02-08 |
Family
ID=32095025
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20151100329T CY1116167T1 (el) | 2002-10-10 | 2015-04-06 | Φαρμακευτικeς συνθεσεις κατευθυνομενες σε υποδοχεις erb-b1 |
Country Status (19)
Country | Link |
---|---|
US (2) | US7226592B2 (el) |
EP (2) | EP1549344B1 (el) |
JP (3) | JP2006505546A (el) |
KR (2) | KR20050057631A (el) |
CN (1) | CN1703243B (el) |
AU (2) | AU2003273964B2 (el) |
BR (2) | BR0315123A (el) |
CA (2) | CA2501821C (el) |
CY (1) | CY1116167T1 (el) |
DK (1) | DK1549344T3 (el) |
ES (1) | ES2533963T3 (el) |
HK (2) | HK1081448A1 (el) |
HU (1) | HUE025086T2 (el) |
MX (2) | MXPA05003796A (el) |
PL (2) | PL210545B1 (el) |
PT (1) | PT1549344E (el) |
RU (2) | RU2354402C2 (el) |
SI (1) | SI1549344T1 (el) |
WO (2) | WO2004032961A1 (el) |
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JPH05320513A (ja) * | 1992-05-26 | 1993-12-03 | Toray Dow Corning Silicone Co Ltd | 粘土状オルガノポリシロキサン組成物 |
CA2120745A1 (en) * | 1992-06-30 | 1994-01-06 | Philip G. Kasprzyk | A combination of anti-erbb-2 monoclonal antibodies and method of using |
US6342219B1 (en) * | 1999-04-28 | 2002-01-29 | Board Of Regents, The University Of Texas System | Antibody compositions for selectively inhibiting VEGF |
AU2001264946A1 (en) * | 2000-05-24 | 2001-12-03 | Imclone Systems Incorporated | Bispecific immunoglobulin-like antigen binding proteins and method of production |
AU2002219221B2 (en) * | 2001-01-09 | 2007-05-17 | Merck Patent Gmbh | Combination therapy using receptor tyrosine kinase inhibitors and angiogenesis inhibitors |
US7132511B2 (en) * | 2001-02-19 | 2006-11-07 | Merck Patent Gmbh | Modified anti-EGFR antibodies with reduced immunogenicity |
SI1549344T1 (sl) * | 2002-10-10 | 2015-05-29 | Merck Patent Gmbh | FARMACEVTSKI SESTAVKI PROTI RECEPTORJEM ErbB1 |
-
2003
- 2003-10-09 SI SI200332421T patent/SI1549344T1/sl unknown
- 2003-10-09 CN CN2003801010871A patent/CN1703243B/zh not_active Expired - Fee Related
- 2003-10-09 MX MXPA05003796A patent/MXPA05003796A/es not_active Application Discontinuation
- 2003-10-09 PL PL374587A patent/PL210545B1/pl unknown
- 2003-10-09 KR KR1020057006038A patent/KR20050057631A/ko not_active Application Discontinuation
- 2003-10-09 PL PL37458603A patent/PL374586A1/xx not_active Application Discontinuation
- 2003-10-09 DK DK03757931.5T patent/DK1549344T3/en active
- 2003-10-09 ES ES03757931.5T patent/ES2533963T3/es not_active Expired - Lifetime
- 2003-10-09 EP EP03757931.5A patent/EP1549344B1/en not_active Expired - Lifetime
- 2003-10-09 HU HUE03757931A patent/HUE025086T2/en unknown
- 2003-10-09 CA CA2501821A patent/CA2501821C/en not_active Expired - Fee Related
- 2003-10-09 EP EP03807851A patent/EP1549345A1/en not_active Withdrawn
- 2003-10-09 CA CA2501818A patent/CA2501818C/en not_active Expired - Fee Related
- 2003-10-09 KR KR1020057006262A patent/KR101088661B1/ko active IP Right Grant
- 2003-10-09 WO PCT/EP2003/011165 patent/WO2004032961A1/en active Application Filing
- 2003-10-09 RU RU2005114480A patent/RU2354402C2/ru active
- 2003-10-09 JP JP2004542466A patent/JP2006505546A/ja active Pending
- 2003-10-09 WO PCT/EP2003/011164 patent/WO2004032960A1/en active Application Filing
- 2003-10-09 AU AU2003273964A patent/AU2003273964B2/en not_active Ceased
- 2003-10-09 MX MXPA05003795A patent/MXPA05003795A/es active IP Right Grant
- 2003-10-09 PT PT37579315T patent/PT1549344E/pt unknown
- 2003-10-09 US US10/530,875 patent/US7226592B2/en not_active Expired - Lifetime
- 2003-10-09 RU RU2005114482A patent/RU2349340C2/ru active
- 2003-10-09 AU AU2003276084A patent/AU2003276084B2/en not_active Ceased
- 2003-10-09 BR BR0315123-9A patent/BR0315123A/pt not_active IP Right Cessation
- 2003-10-09 JP JP2004542465A patent/JP5179702B2/ja not_active Expired - Fee Related
- 2003-10-09 US US10/530,871 patent/US7638125B2/en active Active
- 2003-10-09 BR BR0315117-4A patent/BR0315117A/pt not_active IP Right Cessation
-
2006
- 2006-02-10 HK HK06101772.6A patent/HK1081448A1/xx not_active IP Right Cessation
- 2006-02-10 HK HK06101773.5A patent/HK1081449A1/xx not_active IP Right Cessation
-
2010
- 2010-09-21 JP JP2010211122A patent/JP2010280727A/ja active Pending
-
2015
- 2015-04-06 CY CY20151100329T patent/CY1116167T1/el unknown
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