CY1115080T1 - Μεθοδοι και kit για να διαγνωσκεται ανεπαρκεια αυξητικης ορμονης - Google Patents
Μεθοδοι και kit για να διαγνωσκεται ανεπαρκεια αυξητικης ορμονηςInfo
- Publication number
- CY1115080T1 CY1115080T1 CY20121101144T CY121101144T CY1115080T1 CY 1115080 T1 CY1115080 T1 CY 1115080T1 CY 20121101144 T CY20121101144 T CY 20121101144T CY 121101144 T CY121101144 T CY 121101144T CY 1115080 T1 CY1115080 T1 CY 1115080T1
- Authority
- CY
- Cyprus
- Prior art keywords
- growth hormone
- sample
- kits
- level
- methods
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Endocrinology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
Abstract
Μέθοδος για αξιολόγηση ανεπάρκειας αυξητικής ορμόνης σε ένα ανθρώπινο ή ζωικό υποκείμενο, η δε μέθοδος περιλαμβάνει χορήγηση από του στόματος στο υποκείμενο ΕΡ 1572 (Τύπος σας) ή ΕΡ 1573 (Τύπος II), λήψη δείγματος μετά τη χορήγηση από το υποκείμενο, προσδιορισμό του επιπέδου αυξητικής ορμόνης στο δείγμα και αξιολόγηση κατά πόσον το επίπεδο αυξητικής ορμόνης στο δείγμα είναι ενδεικτικό ανεπάρκειας αυξητικής ορμόνης στο υποκείμενο. Κατά προτίμηση, το επίπεδο GH στο δείγμα μετράται με ανοσοδοκιμασία. Επίσης αποκαλυπτόμενο είναι ένα κιτ μερών που συνίσταται από διαγνωστικό κιτ που περιλαμβάνει: (α) ΕΡ 1572 ή ΕΡ 1573 συνταγοποιημένο για χορήγηση από του στόματος και (β) μέσα για προσδιορισμό του επιπέδου αυξητικής ορμόνης σε ένα δείγμα.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0603295.7A GB0603295D0 (en) | 2006-02-18 | 2006-02-18 | Methods and kits |
EP07712743A EP1984744B1 (en) | 2006-02-18 | 2007-02-19 | Methods and kits to diagnose growth hormone deficiency |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1115080T1 true CY1115080T1 (el) | 2016-12-14 |
Family
ID=36142085
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20121101144T CY1115080T1 (el) | 2006-02-18 | 2012-11-27 | Μεθοδοι και kit για να διαγνωσκεται ανεπαρκεια αυξητικης ορμονης |
Country Status (11)
Country | Link |
---|---|
US (1) | US8192719B2 (el) |
EP (1) | EP1984744B1 (el) |
JP (1) | JP4852728B2 (el) |
CY (1) | CY1115080T1 (el) |
DK (1) | DK1984744T3 (el) |
ES (1) | ES2404582T3 (el) |
GB (1) | GB0603295D0 (el) |
PL (1) | PL1984744T3 (el) |
PT (1) | PT1984744E (el) |
SI (1) | SI1984744T1 (el) |
WO (1) | WO2007093820A1 (el) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8592377B2 (en) | 2007-03-28 | 2013-11-26 | President And Fellows Of Harvard College | Stitched polypeptides |
WO2010135391A2 (en) * | 2009-05-21 | 2010-11-25 | Svetlana Ten | An improved method for diagnosing or predicting short stature in humans |
BR112013003248A2 (pt) | 2010-08-13 | 2016-06-07 | Aileron Therapeutics Inc | "macrociclo peptidomimético e seus usos" |
CN104922182A (zh) * | 2011-03-04 | 2015-09-23 | 狮王株式会社 | 生长激素分泌促进剂 |
CN104039342A (zh) | 2011-10-18 | 2014-09-10 | 爱勒让治疗公司 | 拟肽大环化合物 |
JP6450191B2 (ja) | 2012-02-15 | 2019-01-09 | エイルロン セラピューティクス,インコーポレイテッド | ペプチドミメティック大環状化合物 |
AU2013221433B2 (en) | 2012-02-15 | 2018-01-18 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
MX2015005244A (es) | 2012-11-01 | 2015-07-14 | Aileron Therapeutics Inc | Aminoacidos disustituidos y metodos de preparacion y el uso de los mismos. |
US9119832B2 (en) | 2014-02-05 | 2015-09-01 | The Regents Of The University Of California | Methods of treating mild brain injury |
CN105330720A (zh) * | 2014-06-06 | 2016-02-17 | 深圳翰宇药业股份有限公司 | 一种制备马昔瑞林的方法 |
JP2017533889A (ja) | 2014-09-24 | 2017-11-16 | エルロン・セラピューティクス・インコーポレイテッドAileron Therapeutics,Inc. | ペプチド模倣大環状分子およびその使用 |
MX2017011834A (es) | 2015-03-20 | 2018-04-11 | Aileron Therapeutics Inc | Macrociclos peptidomimeticos y usos de los mismos. |
SI3352752T1 (sl) | 2015-09-21 | 2022-05-31 | Lumos Pharma Inc. | Zaznavanje in zdravljenje pomanjkanja rastnega hormona |
US20170121385A1 (en) | 2015-10-28 | 2017-05-04 | Oxeia Biopharmaceuticals, Inc. | Methods of treating neurodegenerative conditions |
US10288629B1 (en) | 2017-12-19 | 2019-05-14 | Aeterna Zentaris, Inc. | Method of assessing growth hormone deficiency in humans by a macimorelin containing composition |
EP4185866A1 (en) | 2020-07-22 | 2023-05-31 | Aeterna Zentaris GmbH | A screening method for diagnosing growth hormone deficiency in pediatric patients by using macimorelin |
US11644474B2 (en) * | 2020-07-22 | 2023-05-09 | Æterna Zentaris Gmbh | Use of macimorelin in assessing growth hormone deficiency in children |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2746400A1 (de) | 1977-10-15 | 1979-04-19 | Bergner Fa R | Selbstsichernde kopfschraube oder mutter |
US4853371A (en) | 1986-06-17 | 1989-08-01 | The Administrators Of The Tulane Educational Fund | Therapeutic somatostatin analogs |
IT1240643B (it) | 1990-05-11 | 1993-12-17 | Mediolanum Farmaceutici Spa | Peptidi biologicamente attivi contenenti in catena 2-alchiltriptofano |
US5668254A (en) | 1990-05-11 | 1997-09-16 | Romano Deghenghi | D-2-alkyl-tryptophan and peptides containing same |
US5872100A (en) | 1990-05-11 | 1999-02-16 | Deghenghi; Romano | Peptides containing D-2-Alkyl-Tryptophan |
US5811074A (en) | 1992-06-29 | 1998-09-22 | University Of South Florida | Method of diagnosing pituitary dependent growth hormone deficiency |
AU5727194A (en) | 1992-11-13 | 1994-06-08 | The Administrators Of The Tulane Eductional Fund | Ghrh agonists |
WO1994011396A1 (en) | 1992-11-13 | 1994-05-26 | The Administrators Of The Tulane Educational Fund | Ghrh agonists |
AU684878B2 (en) | 1993-11-24 | 1998-01-08 | Merck & Co., Inc. | Compounds and the use thereof to promote the release of growth hormone(s) |
CA2201122A1 (en) | 1994-09-27 | 1996-04-04 | Romano Deghenghi | Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone |
US5798337A (en) | 1994-11-16 | 1998-08-25 | Genentech, Inc. | Low molecular weight peptidomimetic growth hormone secretagogues |
WO1996029002A1 (en) | 1995-03-17 | 1996-09-26 | University Of South Florida | Method of diagnosing pituitary dependent growth hormone deficiency |
IT1277113B1 (it) | 1995-12-20 | 1997-11-04 | Romano Deghenghi | Composti oligopeptidici contenenti d-2-alchiltriptofano in grado di promuovere la liberazione dell'ormone della crescita |
US6730498B1 (en) | 1997-04-08 | 2004-05-04 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Production of functional proteins: balance of shear stress and gravity |
WO1999039730A1 (fr) | 1998-02-09 | 1999-08-12 | Kaken Pharmaceutical Co., Ltd. | Preparation a administration orale contenant des peptides favorisant la secretion d'hormone de croissance |
US5932548A (en) | 1998-06-03 | 1999-08-03 | Deghenghi; Romano | Lysine containing peptides for treatment of heart disease |
US6025471A (en) | 1998-06-03 | 2000-02-15 | Deghenghi; Romano | Diazaspiro, azepino and azabicyclo therapeutic peptides |
US6468974B1 (en) | 1998-08-14 | 2002-10-22 | The Administrators Of The Tulane Educational Fund | Compounds having growth hormone releasing activity |
BRPI0111591B8 (pt) | 2000-06-13 | 2021-05-25 | Aeterna Gmbh | composto, composição farmacêutica, e, usos de um composto |
JP2002168863A (ja) * | 2000-12-05 | 2002-06-14 | Ajinomoto Co Inc | 成長ホルモン分泌調節物質のスクリーニング及び製造方法 |
-
2006
- 2006-02-18 GB GBGB0603295.7A patent/GB0603295D0/en not_active Ceased
-
2007
- 2007-02-19 EP EP07712743A patent/EP1984744B1/en active Active
- 2007-02-19 ES ES07712743T patent/ES2404582T3/es active Active
- 2007-02-19 PL PL07712743T patent/PL1984744T3/pl unknown
- 2007-02-19 DK DK07712743.9T patent/DK1984744T3/da active
- 2007-02-19 SI SI200731091T patent/SI1984744T1/sl unknown
- 2007-02-19 US US12/279,805 patent/US8192719B2/en active Active
- 2007-02-19 PT PT07712743T patent/PT1984744E/pt unknown
- 2007-02-19 WO PCT/GB2007/000566 patent/WO2007093820A1/en active Application Filing
- 2007-02-19 JP JP2008554853A patent/JP4852728B2/ja active Active
-
2012
- 2012-11-27 CY CY20121101144T patent/CY1115080T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
JP2009526989A (ja) | 2009-07-23 |
PL1984744T3 (pl) | 2013-02-28 |
US8192719B2 (en) | 2012-06-05 |
EP1984744B1 (en) | 2012-09-19 |
EP1984744A1 (en) | 2008-10-29 |
ES2404582T3 (es) | 2013-05-28 |
JP4852728B2 (ja) | 2012-01-11 |
US20090305300A1 (en) | 2009-12-10 |
DK1984744T3 (da) | 2012-12-10 |
WO2007093820A1 (en) | 2007-08-23 |
PT1984744E (pt) | 2012-11-29 |
SI1984744T1 (sl) | 2013-01-31 |
GB0603295D0 (en) | 2006-03-29 |
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