CY1114995T1 - Συζευγματα με πολυμερες του κ-252α και παραγωγων αυτοy - Google Patents

Συζευγματα με πολυμερες του κ-252α και παραγωγων αυτοy

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Publication number
CY1114995T1
CY1114995T1 CY20141100227T CY141100227T CY1114995T1 CY 1114995 T1 CY1114995 T1 CY 1114995T1 CY 20141100227 T CY20141100227 T CY 20141100227T CY 141100227 T CY141100227 T CY 141100227T CY 1114995 T1 CY1114995 T1 CY 1114995T1
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Cyprus
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relates
polymers
prevention
treatment
conjugates
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CY20141100227T
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English (en)
Inventor
Silvio Traversa
Raffaella Bagnod
Domenico Barone
Rava Rossa Luisa Bertarione
Silvano Fumero
Valentina Mainero
Alessandra Marconi
Cecilia Oderda
Carlo Pincelli
Chiara Lorenzetto
Luca Beccaria
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Creabilis Therapeutics S.P.A.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37075187&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1114995(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Creabilis Therapeutics S.P.A. filed Critical Creabilis Therapeutics S.P.A.
Publication of CY1114995T1 publication Critical patent/CY1114995T1/el

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    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
    • C08G73/0666—Polycondensates containing five-membered rings, condensed with other rings, with nitrogen atoms as the only ring hetero atoms
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    • C08G61/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G61/12—Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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    • C08G61/12—Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule
    • C08G61/122—Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule derived from five- or six-membered heterocyclic compounds, other than imides
    • C08G61/123—Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule derived from five- or six-membered heterocyclic compounds, other than imides derived from five-membered heterocyclic compounds
    • C08G61/124—Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule derived from five- or six-membered heterocyclic compounds, other than imides derived from five-membered heterocyclic compounds with a five-membered ring containing one nitrogen atom in the ring
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    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Urology & Nephrology (AREA)
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  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Polyethers (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Η παρούσα εφεύρεση σχετίζεται με νέα συζεύγματα με πολυμερή του K-252a και παραγώγων αυτού και με τη χρήση τους για την παρασκευή μιας φαρμακευτικής σύνθεσης χρήσιμης για την πρόληψη, ανακούφιση και θεραπεία παθολογικών καταστάσεων που σχετίζονται με κινάση. Ειδικότερα, η παρούσα εφεύρεση σχετίζεται με την πρόληψη, ανακούφιση και θεραπεία παθολογικών καταστάσεων που σχετίζονται με HMGB1. Σε μια συγκεκριμένη άποψη, η εφεύρεση σχετίζεται με τη χρήση των νέων συζευγμάτων με πολυμερή του K-252a και παραγώγων αυτού για την παρασκευή μιας φαρμακευτικής σύνθεσης χρήσιμης για την πρόληψη, ανακούφιση και θεραπεία νευρολογικών διαταραχών, νευροπαθειών και νευροεκφυλιστικών διαταραχών του κεντρικού και περιφερικού νευρικού συστήματος. Σε μια άλλη προτιμούμενη άποψη, η εφεύρεση σχετίζεται με τη χρήση συζευγμάτων με πολυμερή για την παρασκευή μιας φαρμακευτικής σύνθεσης χρήσιμης για την πρόληψη, ανακούφιση και θεραπεία δερματοπαθολογικών καταστάσεων, και ιδιαίτερα δερματοπαθολογικών καταστάσεων που σχετίζονται με υπερβολικό πολλαπλασιασμό κερατινοκυττάρων, και ιδιαίτερα με ψωρίαση. Σε μια άλλη προτιμούμενη άποψη, η εφεύρεση σχετίζεται με τη χρήση των συζευγμάτων με πολυμερή για την πρόληψη, ανακούφιση και θεραπεία πόνου που σχετίζεται με NGF. Ειδικότερα, η παρούσα εφεύρεση σχετίζεται με ένα σύζευγμα με πολυμερή του K-252a και παραγώγων αυτού, όπου το πολυμερές είναι πολυαιθυλενογλυκόλη ή μεθοξυ-πολυαιθυλενογλυκόλη τύπος (I).
CY20141100227T 2005-08-25 2014-03-24 Συζευγματα με πολυμερες του κ-252α και παραγωγων αυτοy CY1114995T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US71089005P 2005-08-25 2005-08-25
US72045405P 2005-09-27 2005-09-27
US81146906P 2006-06-07 2006-06-07
EP06777076.8A EP1919979B2 (en) 2005-08-25 2006-08-25 Polymer conjugates of k-252a and derivatives thereof

Publications (1)

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CY1114995T1 true CY1114995T1 (el) 2016-12-14

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ID=37075187

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US (1) US8673347B2 (el)
EP (1) EP1919979B2 (el)
JP (1) JP5366548B2 (el)
KR (1) KR101379693B1 (el)
AU (1) AU2006284096B2 (el)
BR (1) BRPI0615277A2 (el)
CA (1) CA2620032C (el)
CY (1) CY1114995T1 (el)
DK (1) DK1919979T4 (el)
EA (1) EA017318B1 (el)
ES (1) ES2444003T5 (el)
HK (1) HK1123563A1 (el)
HR (1) HRP20140218T4 (el)
IL (1) IL189187A (el)
MX (1) MX2008002524A (el)
NZ (1) NZ566160A (el)
PL (1) PL1919979T5 (el)
PT (1) PT1919979E (el)
RS (1) RS53195B2 (el)
SI (1) SI1919979T2 (el)
WO (1) WO2007022999A1 (el)

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