CY1111932T1 - Συνδυασμοι αγωνιστικης βητα-2-αδρενεργικης βενζοθειαζολονης - Google Patents

Συνδυασμοι αγωνιστικης βητα-2-αδρενεργικης βενζοθειαζολονης

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Publication number
CY1111932T1
CY1111932T1 CY20111100976T CY111100976T CY1111932T1 CY 1111932 T1 CY1111932 T1 CY 1111932T1 CY 20111100976 T CY20111100976 T CY 20111100976T CY 111100976 T CY111100976 T CY 111100976T CY 1111932 T1 CY1111932 T1 CY 1111932T1
Authority
CY
Cyprus
Prior art keywords
inhibitor
receptor
hydroxy
ethyl
ylacetoxy
Prior art date
Application number
CY20111100976T
Other languages
English (en)
Inventor
Elaine Bridget Cadogan
Stephen Connolly
David John Nicholls
Katherine Elisabeth Wiley
Alan Young
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CY1111932T1 publication Critical patent/CY1111932T1/el

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Η εφεύρεση παρέχει ένα φαρμακευτικό προϊόν που περιλαμβάνει ένα πρώτο δραστικό συστατικό, το οποίο είναι Ν-[2-(Διαιθυ-λαμινο)αιθυλ]-Ν-(2-{[2-(4-υδροξυ-2-οξο-2,3-διυδρο-1,3-βενζοθειαζολ-7-υλ)αιθυλ]αμινο}αιθυλ)-3-[2-(1-ναφθυλ)αιθοξυ]προπαναμίδιο ή ένα άλας αυτού, και ένα δεύτερο δραστικό συστατικό που επιλέγεται από: ένα μη-στεροειδή Αγωνιστή Υποδοχέος Γλυκοκορτικοειδούς (Υποδοχέας GR)˙ ένα αντιοξειδωτικό˙ έναν ανταγωνιστή CCR1˙ έναν ανταγωνιστή χημοκίνης (όχι μη CCR1)˙ ένα κορτικοστεροειδές˙ έναν ανταγωνιστή CRTh2˙ έναν ανταγωνιστή DP1˙ έναν Επαγωγέα Αποακετυλάσης της Ιστόνης˙ έναν αναστολέα ΙΚΚ2˙ έναν αναστολέα COX˙ έναν αναστολέα λιποξυγενάσης˙ έναν ανταγωνιστή υποδοχέος λευκοτριενίου˙ έναν αναστολέα ΜΡΟ˙ έναν μουσκαρινικό ανταγωνιστή ο οποίος είναι βρωμιούχο Ακλιδίνιο, Γλυκοπυρρολάτη, βρωμιούχο Οξιτρόπιο, Πιρενζεπίνη, τελενζεπίνη, βρωμιούχο Τιοτρόπιο, 3(R)-(2-υδροξυ-2,2-διεθειεν-2-υλακετοξυ)-1-(3-φαινοξυπροπυλ)-1-αζο-νιαδικυκλο[2.2.2]οκτάνιο βρωμιούχο, 3(R)-1-φαιναιθυλ-3-(9Η-ξανθανο-9-καρβονυλοξυ)-1-αζονιαδικυκλο[2.2.2]οκτάνιο βρωμιούχο ή (3R)-3-[(2S)-2-κυκλοπεντυλ-2-υδροξυ-2-θειεν-2-υλακετοξυ]-1-(2-φαινοξυαιθυλ)-1-αζονιαδικυκλο[2.2.2] ακτάνιο βρωμιούχο˙ έναν αναστολέα p38˙ έναν αναστολέα PDE˙ έναν αγωνιστή PPARy˙ έναν αναστολέα πρωτεάσης˙ μία Στατίνη˙ έναν ανταγωνιστή θρομβοξάνης˙ έναν αγγειοδιασταλτικό παράγοντα˙ ή, έναν αναστολέα ENAC (αναστολέας διαύλου Νατρίου Επιθηλίων)˙ και τη χρήση του στη θεραπευτική αντιμετώπιση αναπνευστικών παθήσεων.
CY20111100976T 2007-02-08 2011-10-12 Συνδυασμοι αγωνιστικης βητα-2-αδρενεργικης βενζοθειαζολονης CY1111932T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0702456.5A GB0702456D0 (en) 2007-02-08 2007-02-08 New combination
EP08702047A EP2117542B1 (en) 2007-02-08 2008-02-06 Combinations of beta- 2 -adrenoceptor agonistic benzothiazolone

Publications (1)

Publication Number Publication Date
CY1111932T1 true CY1111932T1 (el) 2015-11-04

Family

ID=37898976

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111100976T CY1111932T1 (el) 2007-02-08 2011-10-12 Συνδυασμοι αγωνιστικης βητα-2-αδρενεργικης βενζοθειαζολονης

Country Status (29)

Country Link
US (2) US20100029732A1 (el)
EP (2) EP2364704A1 (el)
JP (1) JP2010518056A (el)
KR (1) KR20090114391A (el)
CN (1) CN101652137A (el)
AR (1) AR065277A1 (el)
AT (1) ATE520401T1 (el)
AU (1) AU2008212713A1 (el)
BR (1) BRPI0806964A2 (el)
CA (1) CA2675465A1 (el)
CL (1) CL2008000379A1 (el)
CO (1) CO6210723A2 (el)
CY (1) CY1111932T1 (el)
DK (1) DK2117542T3 (el)
EC (1) ECSP099567A (el)
ES (1) ES2368967T3 (el)
GB (1) GB0702456D0 (el)
HR (1) HRP20110695T1 (el)
IL (1) IL199840A0 (el)
MX (1) MX2009007865A (el)
PE (1) PE20081759A1 (el)
PL (1) PL2117542T3 (el)
PT (1) PT2117542E (el)
RS (1) RS51956B (el)
RU (1) RU2009133255A (el)
SI (1) SI2117542T1 (el)
TW (1) TW200843750A (el)
UY (1) UY30906A1 (el)
WO (1) WO2008096111A1 (el)

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TW200738658A (en) * 2005-08-09 2007-10-16 Astrazeneca Ab Novel compounds
TW200738659A (en) * 2005-08-29 2007-10-16 Astrazeneca Ab Novel compounds
TW200745067A (en) 2006-03-14 2007-12-16 Astrazeneca Ab Novel compounds
TW200825084A (en) 2006-11-14 2008-06-16 Astrazeneca Ab New compounds 521
TW200833670A (en) * 2006-12-20 2008-08-16 Astrazeneca Ab Novel compounds 569
GB0702458D0 (en) 2007-02-08 2007-03-21 Astrazeneca Ab Salts 668
KR20110010725A (ko) * 2008-05-13 2011-02-07 아스트라제네카 아베 무스카린성 수용체 길항제 및 β２­아드레날린수용체 효능제를 포함하는 제약 생성물
JP4837800B2 (ja) 2008-05-13 2011-12-14 アストラゼネカ・アクチエボラーグ ムスカリンｍ３受容体アンタゴニストとしてのキヌクリジン誘導体
BRPI0915428A2 (pt) 2008-06-18 2015-11-03 Astrazeneca Ab derivados de benzoxazinona atuando como agonistas adrenorreceptor beta2 para o tratamento de distúrbios respiratórios
EP2303266A4 (en) * 2008-06-20 2015-01-21 Astrazeneca Ab PHARMACEUTICAL COMPOSITION COMPRISING A 4-HYDROXY-2-OXO-2,3-DIHYDRO-1,3-BENZOTHIAZOL-7-YLE COMPOUND FOR THE MODULATION OF BETA-2-ADRENORECEPTOR ACTIVITY
TW201036957A (en) 2009-02-20 2010-10-16 Astrazeneca Ab Novel salt 628
US9827212B2 (en) 2009-03-18 2017-11-28 The Trustees Of The University Of Pennsylvania Compositions and methods for treating asthma and other lung diseases
WO2011011060A1 (en) 2009-07-22 2011-01-27 Puretech Ventures Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation
US10265311B2 (en) 2009-07-22 2019-04-23 PureTech Health LLC Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation
WO2011061527A1 (en) 2009-11-17 2011-05-26 Astrazeneca Ab Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
GB201016912D0 (en) 2010-10-07 2010-11-24 Astrazeneca Ab Novel combination
CN106604720B (zh) 2014-09-09 2020-03-10 维克多瑞有限公司 包含格隆铵的制剂、方法和设备
DK3670499T3 (da) * 2015-05-04 2022-01-03 Astrazeneca Ab Pyrazolderivater, der er anvendelige som inhibitorer af 5-lipoxygenase-aktiverende protein (flap)
JP7096441B2 (ja) 2018-09-28 2022-07-05 カルナ セラピューティックス，インコーポレイテッド ムスカリン受容体活性化によって改善される障害を処置するための組成物及び方法

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Also Published As

Publication number Publication date
CO6210723A2 (es) 2010-10-20
KR20090114391A (ko) 2009-11-03
BRPI0806964A2 (pt) 2014-04-08
RS51956B (en) 2012-02-29
IL199840A0 (en) 2010-04-15
CL2008000379A1 (es) 2008-10-24
PE20081759A1 (es) 2009-01-31
GB0702456D0 (en) 2007-03-21
EP2117542B1 (en) 2011-08-17
ECSP099567A (es) 2009-09-29
CN101652137A (zh) 2010-02-17
DK2117542T3 (da) 2011-10-31
US20080242649A1 (en) 2008-10-02
AU2008212713A1 (en) 2008-08-14
SI2117542T1 (sl) 2011-11-30
CA2675465A1 (en) 2008-08-14
US20100029732A1 (en) 2010-02-04
EP2364704A1 (en) 2011-09-14
PL2117542T3 (pl) 2011-12-30
ATE520401T1 (de) 2011-09-15
TW200843750A (en) 2008-11-16
AR065277A1 (es) 2009-05-27
EP2117542A1 (en) 2009-11-18
WO2008096111A1 (en) 2008-08-14
MX2009007865A (es) 2009-07-31
PT2117542E (pt) 2011-10-06
RU2009133255A (ru) 2011-03-20
UY30906A1 (es) 2008-09-30
HRP20110695T1 (hr) 2011-11-30
JP2010518056A (ja) 2010-05-27
ES2368967T3 (es) 2011-11-24

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