CY1111011T1 - Χρηση των anti-cd40 μονοκλωνικων αντισωματων για την θεραπευτικη αγωγη πολλαπλου μυελωματος - Google Patents
Χρηση των anti-cd40 μονοκλωνικων αντισωματων για την θεραπευτικη αγωγη πολλαπλου μυελωματοςInfo
- Publication number
- CY1111011T1 CY1111011T1 CY20101100927T CY101100927T CY1111011T1 CY 1111011 T1 CY1111011 T1 CY 1111011T1 CY 20101100927 T CY20101100927 T CY 20101100927T CY 101100927 T CY101100927 T CY 101100927T CY 1111011 T1 CY1111011 T1 CY 1111011T1
- Authority
- CY
- Cyprus
- Prior art keywords
- antigen
- multiple myeloma
- antibody
- binding fragment
- antagonist
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Παρέχονται μέθοδοι θεραπείας για την θεραπευτική αγωγή ενός ατόμου με πολλαπλό μυέλωμα. Οι μέθοδοι περιλαμβάνουν χορήγηση μιας θεραπευτικώς αποτελεσματικής ποσότητας ενός αντι-CD40 αντισώματος ανταγωνιστή ή θραύσματος αυτού που προσδένει αντιγόνο σε έναν ασθενή που το χρειάζεται. Το αντι-CD40 αντίσωμα ανταγωνιστής ή ένα θραύσμα αυτού που προσδένει αντιγόνο είναι απαλλαγμένο σημαντικής δραστικότητας αγωνιστή αλλά δείχνει ανταγωνιστική δραστικότητα όταν το αντίσωμα προσδένει σε ένα CD40 αντιγόνο ή σε ένα ανθρώπινο κύτταρο που εκφράζει CD40. Η ανταγωνιστική δραστικότητα του αντι-CD40 αντισώματος ή θραύσματος αυτού που προσδένει αντιγόνο ευεργετικά αναστέλλει τον πολλαπλασιασμό και/ή την διαφοροποίηση των ανθρώπινων κυττάρων πολλαπλού μυελώματος που εκφράζουν CD40.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51733703P | 2003-11-04 | 2003-11-04 | |
| US52557903P | 2003-11-26 | 2003-11-26 | |
| US56570904P | 2004-04-26 | 2004-04-26 | |
| US56571004P | 2004-04-27 | 2004-04-27 | |
| EP04818358A EP1684805B8 (en) | 2003-11-04 | 2004-11-04 | Use of antagonist anti-cd40 monoclonal antibodies for treatment of multiple myeloma |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1111011T1 true CY1111011T1 (el) | 2015-06-11 |
Family
ID=34577849
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20101100927T CY1111011T1 (el) | 2003-11-04 | 2010-10-18 | Χρηση των anti-cd40 μονοκλωνικων αντισωματων για την θεραπευτικη αγωγη πολλαπλου μυελωματος |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20070218060A1 (el) |
| EP (2) | EP2243492A1 (el) |
| JP (2) | JP4765040B2 (el) |
| KR (1) | KR101128777B1 (el) |
| CN (1) | CN1901937B (el) |
| AT (1) | ATE474599T1 (el) |
| CA (1) | CA2544951A1 (el) |
| CY (1) | CY1111011T1 (el) |
| DE (1) | DE602004028272D1 (el) |
| DK (1) | DK1684805T3 (el) |
| ES (1) | ES2346978T3 (el) |
| HK (1) | HK1094162A1 (el) |
| PL (1) | PL1684805T3 (el) |
| PT (1) | PT1684805E (el) |
| SI (1) | SI1684805T1 (el) |
| WO (1) | WO2005044855A2 (el) |
Families Citing this family (50)
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| EP2248830A1 (en) * | 2003-11-04 | 2010-11-10 | Novartis Vaccines and Diagnostics, Inc. | Use of antagonist anti-CD40 antibodies for treatment of autoimmune and inflammatory diseases and organ transplant rejection |
| DK1682177T3 (da) * | 2003-11-04 | 2010-11-01 | Novartis Vaccines & Diagnostic | Anvendelse af antagonist-anti-CD40-antistoffer til behandling af kronisk lymfocytisk leukæmi |
| EP2236172A1 (en) * | 2003-11-04 | 2010-10-06 | Novartis Vaccines and Diagnostics, Inc. | Combination therapy comprising anti-CD20 and anti-CD40 antibodies for the treatment of B cell-related cancers |
| US20050281815A1 (en) * | 2004-02-26 | 2005-12-22 | Dani Eshel | CD40 splice variants and their uses |
| US20070292439A1 (en) * | 2004-04-27 | 2007-12-20 | Novartis Vaccines And Diagnostics, Inc. | Antagonist Anti-Cd40 Monoclonal Antibodies and Methods for Their Use |
| US20080057070A1 (en) * | 2004-11-04 | 2008-03-06 | Chiron Corporation | Antagonist Anti-Cd40 Monoclonal Antibodies and Methods for Their Use |
| WO2006099875A1 (en) | 2005-03-23 | 2006-09-28 | Genmab A/S | Antibodies against cd38 for treatment of multiple myeloma |
| US20090202531A1 (en) * | 2005-11-01 | 2009-08-13 | Novartis Ag | Uses of anti-cd40 antibodies |
| AU2006308606C1 (en) | 2005-11-01 | 2013-07-25 | Novartis Ag | Uses of anti-CD40 antibodies |
| CA2649907A1 (en) | 2006-04-21 | 2007-11-01 | Novartis Ag | Antagonist anti-cd40 antibody pharmaceutical compositions |
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| RS59005B1 (sr) * | 2006-09-26 | 2019-08-30 | Genmab As | Anti-cd38 plus kortikosteroidi plus nekortikosteroidni hemoterapeutik za tretiranje tumora |
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-
2004
- 2004-11-04 WO PCT/US2004/037281 patent/WO2005044855A2/en active Application Filing
- 2004-11-04 DK DK04818358.6T patent/DK1684805T3/da active
- 2004-11-04 JP JP2006538548A patent/JP4765040B2/ja not_active Expired - Fee Related
- 2004-11-04 SI SI200431524T patent/SI1684805T1/sl unknown
- 2004-11-04 CA CA002544951A patent/CA2544951A1/en not_active Abandoned
- 2004-11-04 ES ES04818358T patent/ES2346978T3/es active Active
- 2004-11-04 US US10/578,387 patent/US20070218060A1/en not_active Abandoned
- 2004-11-04 PT PT04818358T patent/PT1684805E/pt unknown
- 2004-11-04 CN CN2004800397665A patent/CN1901937B/zh not_active Expired - Fee Related
- 2004-11-04 EP EP10007492A patent/EP2243492A1/en not_active Withdrawn
- 2004-11-04 DE DE602004028272T patent/DE602004028272D1/de active Active
- 2004-11-04 EP EP04818358A patent/EP1684805B8/en not_active Not-in-force
- 2004-11-04 AT AT04818358T patent/ATE474599T1/de active
- 2004-11-04 PL PL04818358T patent/PL1684805T3/pl unknown
- 2004-11-04 KR KR1020067010908A patent/KR101128777B1/ko not_active IP Right Cessation
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2007
- 2007-02-01 HK HK07101253A patent/HK1094162A1/xx not_active IP Right Cessation
-
2010
- 2010-10-18 CY CY20101100927T patent/CY1111011T1/el unknown
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2011
- 2011-02-18 JP JP2011033977A patent/JP2011098989A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005044855A2 (en) | 2005-05-19 |
| CN1901937A (zh) | 2007-01-24 |
| SI1684805T1 (sl) | 2010-11-30 |
| EP1684805B1 (en) | 2010-07-21 |
| CA2544951A1 (en) | 2005-05-19 |
| KR20060135643A (ko) | 2006-12-29 |
| KR101128777B1 (ko) | 2012-04-13 |
| WO2005044855A3 (en) | 2005-09-15 |
| EP1684805A2 (en) | 2006-08-02 |
| CN1901937B (zh) | 2011-08-03 |
| JP2011098989A (ja) | 2011-05-19 |
| EP1684805B8 (en) | 2010-08-25 |
| ES2346978T3 (es) | 2010-10-22 |
| DK1684805T3 (da) | 2010-10-04 |
| JP4765040B2 (ja) | 2011-09-07 |
| ATE474599T1 (de) | 2010-08-15 |
| US20070218060A1 (en) | 2007-09-20 |
| HK1094162A1 (en) | 2007-03-23 |
| DE602004028272D1 (de) | 2010-09-02 |
| JP2008500956A (ja) | 2008-01-17 |
| PL1684805T3 (pl) | 2010-12-31 |
| EP2243492A1 (en) | 2010-10-27 |
| PT1684805E (pt) | 2010-10-26 |
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