CY1110010T1 - Πυριδιναμινοσουλφονυλ υποκατεστημενα βενζαμιδια ως αναστολεις κυτοχρωματος ρ450 3α4 (cyp3a4) - Google Patents
Πυριδιναμινοσουλφονυλ υποκατεστημενα βενζαμιδια ως αναστολεις κυτοχρωματος ρ450 3α4 (cyp3a4)Info
- Publication number
- CY1110010T1 CY1110010T1 CY20101100359T CY101100359T CY1110010T1 CY 1110010 T1 CY1110010 T1 CY 1110010T1 CY 20101100359 T CY20101100359 T CY 20101100359T CY 101100359 T CY101100359 T CY 101100359T CY 1110010 T1 CY1110010 T1 CY 1110010T1
- Authority
- CY
- Cyprus
- Prior art keywords
- pyrochin
- pyridinaminosulphonyl
- benzamyms
- cyp3a4
- inhibitors
- Prior art date
Links
- 102000004328 Cytochrome P-450 CYP3A Human genes 0.000 title 1
- 108010081668 Cytochrome P-450 CYP3A Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Abstract
Η παρούσα εφεύρεση παρέχει ενώσεις του τύπου (I)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72015105P | 2005-09-23 | 2005-09-23 | |
US72311505P | 2005-10-03 | 2005-10-03 | |
US72546905P | 2005-10-11 | 2005-10-11 | |
US76225606P | 2006-01-25 | 2006-01-25 | |
US82166406P | 2006-08-07 | 2006-08-07 | |
EP06795544A EP1937639B1 (en) | 2005-09-23 | 2006-09-11 | Pyridinaminosulfonyl substituted benzamides as inhibitors of cytochrome p450 3a4 (cyp3a4) |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1110010T1 true CY1110010T1 (el) | 2015-01-14 |
Family
ID=37889174
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20101100359T CY1110010T1 (el) | 2005-09-23 | 2010-04-20 | Πυριδιναμινοσουλφονυλ υποκατεστημενα βενζαμιδια ως αναστολεις κυτοχρωματος ρ450 3α4 (cyp3a4) |
Country Status (29)
Country | Link |
---|---|
US (1) | US7868026B2 (el) |
EP (1) | EP1937639B1 (el) |
JP (1) | JP4336738B2 (el) |
KR (1) | KR100975448B1 (el) |
CN (1) | CN101287708B (el) |
AT (1) | ATE459603T1 (el) |
AU (1) | AU2006293605B2 (el) |
BR (1) | BRPI0616156A2 (el) |
CA (1) | CA2621805C (el) |
CY (1) | CY1110010T1 (el) |
DE (1) | DE602006012713D1 (el) |
DK (1) | DK1937639T3 (el) |
EA (1) | EA014329B1 (el) |
EC (1) | ECSP088296A (el) |
ES (1) | ES2340200T3 (el) |
GE (1) | GEP20115230B (el) |
HK (1) | HK1120506A1 (el) |
HR (1) | HRP20100272T2 (el) |
IL (1) | IL189666A (el) |
MA (1) | MA29791B1 (el) |
MY (1) | MY143391A (el) |
NO (1) | NO20081844L (el) |
NZ (1) | NZ566136A (el) |
PL (1) | PL1937639T3 (el) |
PT (1) | PT1937639E (el) |
RS (2) | RS20080118A (el) |
SI (1) | SI1937639T1 (el) |
TN (1) | TNSN08139A1 (el) |
WO (1) | WO2007034312A2 (el) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ574207A (en) * | 2006-07-05 | 2010-10-29 | Pfizer Prod Inc | Pyrazole derivatives as cytochrome p450 inhibitors |
AU2007343726A1 (en) * | 2006-12-26 | 2008-07-24 | Amgen Inc. | N-cyclohexyl benzamides and benzeneacetamides as inhibitors of 11-beta-hydroxysteroid dehydrogenases |
CN101669030B (zh) | 2007-03-08 | 2016-01-13 | 小利兰·斯坦福大学托管委员会 | 线粒体醛脱氢酶2调节剂和其使用方法 |
WO2009043784A1 (en) * | 2007-10-04 | 2009-04-09 | F. Hoffmann-La Roche Ag | Cyclopropyl aryl amide derivatives and uses thereof |
JP2012502048A (ja) | 2008-09-08 | 2012-01-26 | ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ | アルデヒドデヒドロゲナーゼ活性のモジュレーターおよびその使用方法 |
US8389522B2 (en) * | 2008-10-28 | 2013-03-05 | The Board Of Trustees Of The Leland Stanford Junior University | Modulators of aldehyde dehydrogenase and methods of use thereof |
DK2385938T3 (en) | 2009-01-12 | 2015-04-27 | Pfizer Ltd | Sulfonamidderivater |
MX2011011428A (es) * | 2009-05-01 | 2011-11-29 | Raqualia Pharma Inc | Derivados de acido sulfamoilbenzoico como antagonistas de trpm8. |
US9145407B2 (en) | 2010-07-09 | 2015-09-29 | Pfizer Limited | Sulfonamide compounds |
US10457659B2 (en) | 2011-04-29 | 2019-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for increasing proliferation of adult salivary stem cells |
CN104540813A (zh) * | 2012-06-27 | 2015-04-22 | 默沙东公司 | 磺酰胺衍生物以及使用它们用于改善药物的药物动力学的方法 |
WO2014000178A1 (en) * | 2012-06-27 | 2014-01-03 | Merck Sharp & Dohme Corp. | Sulfonamide derivatives and methods of use thereof for improving the pharmacokinetics of a drug |
JP6410790B2 (ja) | 2013-03-14 | 2018-10-24 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | ミトコンドリアアルデヒドデヒドロゲナーゼ−2調節因子およびその使用方法 |
TW201512171A (zh) | 2013-04-19 | 2015-04-01 | Pfizer Ltd | 化學化合物 |
WO2014194519A1 (en) | 2013-06-07 | 2014-12-11 | Merck Sharp & Dohme Corp. | Imidazole derivatives and methods of use thereof for improving pharmacokinetics of drug |
WO2015070366A1 (en) | 2013-11-12 | 2015-05-21 | Merck Sharp & Dohme Corp. | Aryl linked imidazole and triazole derivatives and methods of use thereof for improving the pharmacokinetics of a drug |
WO2015070367A1 (en) * | 2013-11-12 | 2015-05-21 | Merck Sharp & Dohme Corp. | Piperidine or piperazine linked imidazole and triazole derivatives and methods of use thereof for improving the pharmacokinetics of a drug |
HUE046820T2 (hu) | 2014-03-26 | 2020-03-30 | Hoffmann La Roche | Biciklusos vegyületek autotaxin (ATX) és lizofoszfatidsav (LPA) termelésgátlókként |
WO2016101118A1 (en) * | 2014-12-23 | 2016-06-30 | Merck Sharp & Dohme Corp. | Amidoethyl azole orexin receptor antagonists |
CR20180058A (es) | 2015-09-04 | 2018-02-26 | Hoffmann La Roche | Nuevos derivados de fenoximetilo |
WO2018167113A1 (en) | 2017-03-16 | 2018-09-20 | F. Hoffmann-La Roche Ag | New bicyclic compounds as atx inhibitors |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7169763B2 (en) * | 2002-02-22 | 2007-01-30 | Oliver Yoa-Pu Hu | Cytochrome P450 3A inhibitors and enhancers |
-
2006
- 2006-09-11 WO PCT/IB2006/002639 patent/WO2007034312A2/en active Application Filing
- 2006-09-11 SI SI200630666T patent/SI1937639T1/sl unknown
- 2006-09-11 DK DK06795544.3T patent/DK1937639T3/da active
- 2006-09-11 PT PT06795544T patent/PT1937639E/pt unknown
- 2006-09-11 KR KR1020087006967A patent/KR100975448B1/ko not_active IP Right Cessation
- 2006-09-11 GE GEAP200610575A patent/GEP20115230B/en unknown
- 2006-09-11 EA EA200800542A patent/EA014329B1/ru not_active IP Right Cessation
- 2006-09-11 AT AT06795544T patent/ATE459603T1/de active
- 2006-09-11 CN CN2006800348278A patent/CN101287708B/zh not_active Expired - Fee Related
- 2006-09-11 EP EP06795544A patent/EP1937639B1/en active Active
- 2006-09-11 AU AU2006293605A patent/AU2006293605B2/en not_active Ceased
- 2006-09-11 CA CA2621805A patent/CA2621805C/en not_active Expired - Fee Related
- 2006-09-11 NZ NZ566136A patent/NZ566136A/en not_active IP Right Cessation
- 2006-09-11 RS RSP-2008/0118A patent/RS20080118A/sr unknown
- 2006-09-11 PL PL06795544T patent/PL1937639T3/pl unknown
- 2006-09-11 ES ES06795544T patent/ES2340200T3/es active Active
- 2006-09-11 BR BRPI0616156-1A patent/BRPI0616156A2/pt not_active IP Right Cessation
- 2006-09-11 RS RSP-2010/0237A patent/RS51349B/en unknown
- 2006-09-11 JP JP2008531812A patent/JP4336738B2/ja not_active Expired - Fee Related
- 2006-09-11 DE DE602006012713T patent/DE602006012713D1/de active Active
-
2007
- 2007-01-09 US US11/621,410 patent/US7868026B2/en not_active Expired - Fee Related
-
2008
- 2008-02-21 IL IL189666A patent/IL189666A/en not_active IP Right Cessation
- 2008-03-19 MA MA30764A patent/MA29791B1/fr unknown
- 2008-03-19 EC EC2008008296A patent/ECSP088296A/es unknown
- 2008-03-19 TN TNP2008000139A patent/TNSN08139A1/fr unknown
- 2008-03-21 MY MYPI20080779A patent/MY143391A/en unknown
- 2008-04-16 NO NO20081844A patent/NO20081844L/no not_active Application Discontinuation
- 2008-12-15 HK HK08113572.1A patent/HK1120506A1/xx not_active IP Right Cessation
-
2010
- 2010-04-20 CY CY20101100359T patent/CY1110010T1/el unknown
- 2010-05-14 HR HR20100272T patent/HRP20100272T2/hr unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1110010T1 (el) | Πυριδιναμινοσουλφονυλ υποκατεστημενα βενζαμιδια ως αναστολεις κυτοχρωματος ρ450 3α4 (cyp3a4) | |
ES2338590T3 (es) | Procedimiento regioselectivo de preparacion de benzoimidazoltiofenos. | |
UY29612A1 (es) | Compuestos quimicos ii | |
EA200900945A1 (ru) | Новый способ синтеза агомелатина | |
CY1112829T1 (el) | Νεα μεθοδος συνθεσης για την αγομελατινη | |
CY1112102T1 (el) | Υποκατεστημενες πυριμιδοδιαζεπινες χρησιμες ως αναστολεις plk1 | |
CY1112467T1 (el) | Παραγωγα 1-θειο-d-γλυκιτολης | |
EA201001359A1 (ru) | Гетероциклические соединения в качестве ингибиторов cxcr2 | |
MX339476B (es) | Compuestos que incluyen un nucleo farmaceutico antiinflamatorio y sus metodos de uso. | |
CY1112705T1 (el) | Συντηγμενες κυκλικες ενωσεις | |
ATE400567T1 (de) | Kinaseinhibitoren | |
ATE547415T1 (de) | Inhibitoren der wechselwirkung zwischen mdm2 und p53 | |
WO2006133147A3 (en) | Organic compounds | |
EA200801145A1 (ru) | Спироциклические производные хиназолина в качестве ингибиторов pde7 | |
CR20120421A (es) | Compuestos de aminohetetoarilo o sustituidos con pirazol como inhibidores de proteina quinasa | |
CY1112914T1 (el) | Υποκατεστημενα παραγωγα ινδολυλ αλκυλ αμινης ως νεοι αναστολεις των αποακετυλασων ιστονης | |
DK2292607T3 (da) | Fremgangsmåde til syntese af organiske forbindelser | |
ATE548374T1 (de) | 2'-fluor-2'-desoxytetrahydrouridine als cytidindeaminaseinhibitoren | |
ATE483000T1 (de) | Naphtalin-amidin-imide | |
TW200716543A (en) | Chemical compounds VII | |
CY1109234T1 (el) | Αναστολεις κινασης | |
EA200801366A1 (ru) | Производные 3,6-дигидро-2-оксо-6н-1,3,4-тиадиазина | |
ATE417849T1 (de) | Pyrazoloä4,3-düpyrimidine | |
EA200801365A1 (ru) | Замещенные 5-фенил-3,6-дигидро-2-оксо-6h-1,3,4-тиадиазины | |
EA200801549A1 (ru) | Новые производные фенантридина в качестве антагонистов брадикинина |