CY1109369T1 - Υποκατεστημενες πυρρολοπυριδινες, οι ενωσεις που τις περιεχουν, η διαδικασια παρασκευης τους και η χρηση τους - Google Patents

Υποκατεστημενες πυρρολοπυριδινες, οι ενωσεις που τις περιεχουν, η διαδικασια παρασκευης τους και η χρηση τους

Info

Publication number
CY1109369T1
CY1109369T1 CY20091100957T CY091100957T CY1109369T1 CY 1109369 T1 CY1109369 T1 CY 1109369T1 CY 20091100957 T CY20091100957 T CY 20091100957T CY 091100957 T CY091100957 T CY 091100957T CY 1109369 T1 CY1109369 T1 CY 1109369T1
Authority
CY
Cyprus
Prior art keywords
manufacturing process
compounds containing
substituted pyrrolopyridines
pyrrolopyridines
substituted
Prior art date
Application number
CY20091100957T
Other languages
English (en)
Inventor
Michel Tabart
Eric Bacque
Frank Halley
Baptiste Ronan
Pascal Desmazeau
Fabrice Viviani
Catherine Souaille
Original Assignee
Aventis Pharma S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma S.A. filed Critical Aventis Pharma S.A.
Publication of CY1109369T1 publication Critical patent/CY1109369T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Υποκατεστημένες πυρρολοπυριδίνες, συνθέσεις που τις περιέχουν, διαδικασία παρασκευής και χρήση. Η παρούσα εφεύρεση αφορά κυρίως στην παρασκευή υποκατεστημένων πυρρολοπυριδινών, σε συνθέσεις που τις περιέχουν, στη διαδικασία παρασκευής τους και στη χρήση τους ως φαρμάκου, και κυρίως ως αντικαρκινικών παραγόντων. (Χημικός τύπος Ι).
CY20091100957T 2005-04-26 2009-09-16 Υποκατεστημενες πυρρολοπυριδινες, οι ενωσεις που τις περιεχουν, η διαδικασια παρασκευης τους και η χρηση τους CY1109369T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0504173A FR2884821B1 (fr) 2005-04-26 2005-04-26 Pyrrolopyridines substitues, compositions les contenant, procede de fabrication et utilisation
EP06743743A EP1877409B1 (fr) 2005-04-26 2006-04-26 Pyrrolopyridines substitues, compositions les contenant, procede de fabrication et utilisation

Publications (1)

Publication Number Publication Date
CY1109369T1 true CY1109369T1 (el) 2014-07-02

Family

ID=35517344

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20091100957T CY1109369T1 (el) 2005-04-26 2009-09-16 Υποκατεστημενες πυρρολοπυριδινες, οι ενωσεις που τις περιεχουν, η διαδικασια παρασκευης τους και η χρηση τους

Country Status (33)

Country Link
US (1) US7947706B2 (el)
EP (1) EP1877409B1 (el)
JP (1) JP2008539211A (el)
KR (1) KR20080007229A (el)
CN (1) CN101166739A (el)
AR (1) AR061386A1 (el)
AT (1) ATE433976T1 (el)
AU (1) AU2006239105A1 (el)
BR (1) BRPI0613161A2 (el)
CA (1) CA2605744A1 (el)
CR (1) CR9463A (el)
CY (1) CY1109369T1 (el)
DE (1) DE602006007337D1 (el)
DK (1) DK1877409T3 (el)
DO (1) DOP2006000096A (el)
EA (1) EA012983B1 (el)
ES (1) ES2328629T3 (el)
FR (1) FR2884821B1 (el)
GT (1) GT200600174A (el)
HR (1) HRP20090494T1 (el)
IL (1) IL186523A0 (el)
MA (1) MA29480B1 (el)
MX (1) MX2007013084A (el)
NO (1) NO20075918L (el)
PA (1) PA8671301A1 (el)
PE (1) PE20071420A1 (el)
PL (1) PL1877409T3 (el)
PT (1) PT1877409E (el)
RS (1) RS51136B (el)
SI (1) SI1877409T1 (el)
TN (1) TNSN07360A1 (el)
TW (1) TW200718701A (el)
WO (1) WO2006114520A2 (el)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
EP2223925A1 (en) * 2006-10-09 2010-09-01 Takeda Pharmaceutical Company Limited Kinase inhibitors
SG158147A1 (en) * 2006-10-09 2010-01-29 Takeda Pharmaceutical Kinase inhibitors
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
AR064491A1 (es) * 2006-12-22 2009-04-08 Astex Therapeutics Ltd Derivados de imidazo[1, 2-a]pirimidina, un proceso para su preparacion, una composicion farmaceutica que los comprende y su uso en el tratamiento de enfermedades mediadas por las quinasas fgfr.
JP5442449B2 (ja) 2006-12-22 2014-03-12 アステックス、セラピューティックス、リミテッド 新規化合物
WO2009012283A1 (en) 2007-07-17 2009-01-22 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
GB0720041D0 (en) 2007-10-12 2007-11-21 Astex Therapeutics Ltd New Compounds
GB0720038D0 (en) 2007-10-12 2007-11-21 Astex Therapeutics Ltd New compounds
GB0810902D0 (en) * 2008-06-13 2008-07-23 Astex Therapeutics Ltd New compounds
DE102008052943A1 (de) 2008-10-23 2010-04-29 Merck Patent Gmbh Azaindolderivate
ES2552386T3 (es) 2009-04-03 2015-11-27 F. Hoffmann-La Roche Ag Composiciones de {3-[5-(4-cloro-fenil)-1H-pirrol[2,3-b]piridin-3-carbonil]-2,4-difluoro-fenil}-amida del ácido propano-1-sulfónico y usos de las mismas
GB0906470D0 (en) 2009-04-15 2009-05-20 Astex Therapeutics Ltd New compounds
GB0906472D0 (en) 2009-04-15 2009-05-20 Astex Therapeutics Ltd New compounds
US20110030037A1 (en) * 2009-07-07 2011-02-03 Vadim Olshansky Zone migration in network access
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
JP2013510166A (ja) 2009-11-06 2013-03-21 プレキシコン インコーポレーテッド キナーゼ調節のための化合物、方法およびその適用
AU2012214762B2 (en) 2011-02-07 2015-08-13 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
EP2855477A4 (en) * 2012-05-29 2015-11-18 Merck Sharp & Dohme BARYARY COMPOUNDS, ISOTOPICALLY MARKED
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
US20140275082A1 (en) * 2013-03-14 2014-09-18 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
GB201310460D0 (en) * 2013-06-12 2013-07-24 Lytix Biopharma As Compounds
GB201310464D0 (en) * 2013-06-12 2013-07-24 Lytix Biopharma As Compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3254843B2 (ja) * 1993-08-09 2002-02-12 三菱ウェルファーマ株式会社 新規縮合ヘテロ環誘導体
US6335342B1 (en) * 2000-06-19 2002-01-01 Pharmacia & Upjohn S.P.A. Azaindole derivatives, process for their preparation, and their use as antitumor agents
GB0115109D0 (en) * 2001-06-21 2001-08-15 Aventis Pharma Ltd Chemical compounds
JP2005508904A (ja) * 2001-09-11 2005-04-07 スミスクライン ビーチャム コーポレーション 血管新生阻害剤としてのフロ−及びチエノピリミジン誘導体
WO2003028724A1 (en) * 2001-10-04 2003-04-10 Smithkline Beecham Corporation Chk1 kinase inhibitors
WO2003035621A1 (en) * 2001-10-22 2003-05-01 The Research Foundation Of State University Of New York Protein kinase and phosphatase inhibitors, methods for designing them, and methods of using them
CN100368411C (zh) * 2002-03-28 2008-02-13 卫材R&D管理有限公司 作为c-Jun N-末端激酶抑制剂用于治疗神经变性疾病的7-氮杂吲哚类化合物
FR2878849B1 (fr) * 2004-12-06 2008-09-12 Aventis Pharma Sa Indoles substitues, compositions les contenant, procede de fabrication et utilisation

Also Published As

Publication number Publication date
EA012983B1 (ru) 2010-02-26
SI1877409T1 (sl) 2009-12-31
PL1877409T3 (pl) 2009-12-31
EP1877409B1 (fr) 2009-06-17
EA200702329A1 (ru) 2008-02-28
PE20071420A1 (es) 2007-01-20
CR9463A (es) 2008-02-21
JP2008539211A (ja) 2008-11-13
DE602006007337D1 (de) 2009-07-30
RS51136B (sr) 2010-10-31
US20080139606A1 (en) 2008-06-12
ATE433976T1 (de) 2009-07-15
HRP20090494T1 (hr) 2009-10-31
ES2328629T3 (es) 2009-11-16
DOP2006000096A (es) 2007-04-15
FR2884821B1 (fr) 2007-07-06
TW200718701A (en) 2007-05-16
AR061386A1 (es) 2008-08-27
BRPI0613161A2 (pt) 2010-12-21
IL186523A0 (en) 2008-01-20
KR20080007229A (ko) 2008-01-17
EP1877409A2 (fr) 2008-01-16
DK1877409T3 (da) 2009-10-05
MX2007013084A (es) 2008-01-11
TNSN07360A1 (en) 2008-12-31
PT1877409E (pt) 2009-09-16
CN101166739A (zh) 2008-04-23
PA8671301A1 (es) 2006-12-07
WO2006114520A3 (fr) 2007-03-01
AU2006239105A1 (en) 2006-11-02
FR2884821A1 (fr) 2006-10-27
GT200600174A (es) 2006-12-26
MA29480B1 (fr) 2008-05-02
WO2006114520A2 (fr) 2006-11-02
US7947706B2 (en) 2011-05-24
CA2605744A1 (fr) 2006-11-02
NO20075918L (no) 2007-11-19

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