CY1109257T1 - Χιμαιρικες πρωτεϊνες l1 του ιου 16 ανθρωπινων θηλωματων που περιλαμβανουν l2 πεπτιδιο, ομοιαζοντα με ιο σωματιδια που παρασκευαζονται απο αυτες και μεθοδος παρασκευης των σωματιδιων - Google Patents

Χιμαιρικες πρωτεϊνες l1 του ιου 16 ανθρωπινων θηλωματων που περιλαμβανουν l2 πεπτιδιο, ομοιαζοντα με ιο σωματιδια που παρασκευαζονται απο αυτες και μεθοδος παρασκευης των σωματιδιων

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Publication number
CY1109257T1
CY1109257T1 CY20091100595T CY091100595T CY1109257T1 CY 1109257 T1 CY1109257 T1 CY 1109257T1 CY 20091100595 T CY20091100595 T CY 20091100595T CY 091100595 T CY091100595 T CY 091100595T CY 1109257 T1 CY1109257 T1 CY 1109257T1
Authority
CY
Cyprus
Prior art keywords
peptide
dna sequence
polypeptide
juv
similar
Prior art date
Application number
CY20091100595T
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English (en)
Inventor
Arvind Devshi Varsani
Edward Peter Rybicki
Original Assignee
University Of Cape Town
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29550639&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1109257(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by University Of Cape Town filed Critical University Of Cape Town
Publication of CY1109257T1 publication Critical patent/CY1109257T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20023—Virus like particles [VLP]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Η εφεύρεση περιγράφει μέθοδο παρασκευής ενός χιμαιρικού L1 πολυπεπτιδίου ιού ανθρώπινων θηλωμάτων (HPV) που περιέχει ετερόλογο πεπτίδιο και συγκεκριμένα HPV L2 πεπτίδιο. Η μέθοδος περιλαμβάνει τα στάδια εισαγωγής μιας DNA αλληλουχίας που κωδικοποιεί το ετερόλογο πεπτίδιο εντός μιας DNA αλληλουχίας που κωδικοποιεί το L1 πολυπεπτίδιο, εισαγωγή της DNA αλληλουχίας που συμπεριλαμβάνει τις αλληλουχίες για το L1 πολυπεπτίδιο και ετερόλογο πεπτίδιο εντός ενός κυττάρου ξενιστή, όπου η DNA αλληλουχία μπορεί να εκφράζεται, προκαλώντας έκφραση της DNA αλληλουχίας και ανάκτηση του προκύπτοντος χιμαιρικού L1 πολυπεπτιδίου, το οποίο περιλαμβάνει το ετερόλογο πεπτίδιο. Τυπικά τα νουκλεοτίδια που κωδικοποιούν το ετερόλογο πεπτίδιο αντικαθιστούν τα νουκλεοτίδια του L1 πολυπεπτιδίου στο σημείο εισαγωγής. Η εφεύρεση επίσης περιγράφει φορέα για χρήση στη μέθοδο, κύτταρο ξενιστή που περιέχει το φορέα και ένα εμβόλιο που συμπεριλαμβάνει το χιμαιρικό HPV L1 πολυπεπτίδιο που παράγεται σύμφωνα με τη μέθοδο.
CY20091100595T 2002-05-17 2009-06-04 Χιμαιρικες πρωτεϊνες l1 του ιου 16 ανθρωπινων θηλωματων που περιλαμβανουν l2 πεπτιδιο, ομοιαζοντα με ιο σωματιδια που παρασκευαζονται απο αυτες και μεθοδος παρασκευης των σωματιδιων CY1109257T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ZA200203957 2002-05-17
EP03727750A EP1506222B2 (en) 2002-05-17 2003-05-19 Chimeric human papillomavirus 16 l1 proteins comprising an l2 peptide, virus-like particles prepared therefrom and a method for preparing the particles

Publications (1)

Publication Number Publication Date
CY1109257T1 true CY1109257T1 (el) 2014-07-02

Family

ID=29550639

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20091100595T CY1109257T1 (el) 2002-05-17 2009-06-04 Χιμαιρικες πρωτεϊνες l1 του ιου 16 ανθρωπινων θηλωματων που περιλαμβανουν l2 πεπτιδιο, ομοιαζοντα με ιο σωματιδια που παρασκευαζονται απο αυτες και μεθοδος παρασκευης των σωματιδιων

Country Status (13)

Country Link
US (2) US7407807B2 (el)
EP (1) EP1506222B2 (el)
JP (2) JP4614765B2 (el)
AT (1) ATE424409T1 (el)
AU (1) AU2003232951B2 (el)
CA (1) CA2486450C (el)
CY (1) CY1109257T1 (el)
DE (1) DE60326449D1 (el)
DK (1) DK1506222T3 (el)
ES (1) ES2323634T5 (el)
PT (1) PT1506222E (el)
SI (1) SI1506222T1 (el)
WO (1) WO2003097673A2 (el)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0228715D0 (en) * 2002-12-09 2003-01-15 Glaxosmithkline Biolog Sa Vaccine
CN103031310B (zh) 2005-04-29 2018-09-14 开普敦大学 在植物中表达蛋白质
ES2310062B1 (es) 2005-07-15 2009-11-13 Bionostra, S.L. Particulas pseudovirales vacias quimericas derivadas del virus causante de la enfermedad de la bursitis infecciosa (ibdv), procedimiento de obtencion y aplicaciones.
CN1328287C (zh) * 2005-12-29 2007-07-25 西安交通大学 Hpv16 l1蛋白模拟肽及其用于制备hpv16诊断试剂和疫苗的用途
CA2703066A1 (en) * 2007-10-22 2009-04-30 University Of Rochester Respiratory syncytial virus vaccine based on chimeric papillomavirus virus-like particles or capsomeres
CN102497880A (zh) * 2009-06-25 2012-06-13 葛兰素史密丝克莱恩生物有限公司 新的人***状瘤病毒(hpv)蛋白构建体及其在预防hpv疾病中的用途
US20120225090A1 (en) * 2009-08-03 2012-09-06 The Johns Hopkins University Methods for enhancing antigen-specific immune responses
JP6153866B2 (ja) 2010-05-25 2017-06-28 キアゲン ガイサーズバーグ アイエヌシー． 迅速なハイブリッド捕捉アッセイ、及び関連する戦略的に切断されたプローブ
MX355352B (es) * 2011-12-01 2018-04-17 Univ Cape Town Particulas quimericas de vph.
US20160175426A1 (en) * 2013-07-16 2016-06-23 University Of Louisville Research Foundation, Inc. Compositions for mucusal delivery, useful for treating papillomavirus infections
JP7017811B2 (ja) * 2020-02-13 2022-02-09 国立研究開発法人農業・食品産業技術総合研究機構 ウイルス様粒子及びその使用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5618536A (en) * 1992-09-03 1997-04-08 The United States Of America As Represented By The Department Of Health And Human Services Chimeric papillomavirus-like particles
CA2202090C (en) * 1994-10-07 2012-04-17 Lutz Gissmann Papilloma virus-like particles, fusion proteins as well as processes for their production
GB9621091D0 (en) * 1996-10-09 1996-11-27 Fondation Pour Le Perfectionem Attenuated microorganisms strains and their uses
US6228368B1 (en) † 1997-10-06 2001-05-08 Loyola University Of Chicago Papilloma virus capsomere formulations and method of use
US6926897B1 (en) † 1998-03-24 2005-08-09 Medigene Aktiengesellschaft Medicament for the avoidance or treatment of papillomavirus-specific tumour
DE19812941A1 (de) † 1998-03-24 1999-10-07 Medigene Ag Arzneimittel zur Vermeidung oder Behandlung von Papillomavirusspezifischem Tumor
AU753391B2 (en) * 1998-08-14 2002-10-17 Merck Sharp & Dohme Corp. Protein delivery system using human papillomavirus virus-like particles
GB9921146D0 (en) † 1999-09-07 1999-11-10 Smithkline Beecham Biolog Novel composition
DK2416798T3 (en) † 2009-04-10 2018-01-08 Univ Johns Hopkins PAPILLOMAVIRUS-LIKE PARTICLES (VLP) AS WIDE-SPECIFIED VACCINES AGAINST HUMAN PAPILLOMAVIRUS (HPV)

Also Published As

Publication number Publication date
JP4614765B2 (ja) 2011-01-19
ATE424409T1 (de) 2009-03-15
AU2003232951A1 (en) 2003-12-02
WO2003097673B1 (en) 2004-04-22
EP1506222A2 (en) 2005-02-16
JP2010263899A (ja) 2010-11-25
PT1506222E (pt) 2009-06-12
US20060035319A1 (en) 2006-02-16
CA2486450A1 (en) 2003-11-27
US20090047302A1 (en) 2009-02-19
US7407807B2 (en) 2008-08-05
WO2003097673A3 (en) 2004-03-18
WO2003097673A2 (en) 2003-11-27
DE60326449D1 (de) 2009-04-16
US8163557B2 (en) 2012-04-24
CA2486450C (en) 2013-11-19
ES2323634T3 (es) 2009-07-22
EP1506222B1 (en) 2009-03-04
SI1506222T1 (sl) 2009-10-31
EP1506222B2 (en) 2012-05-23
DK1506222T3 (da) 2009-07-06
JP2006507797A (ja) 2006-03-09
AU2003232951B2 (en) 2009-07-23
ES2323634T5 (es) 2012-09-04

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