CY1109257T1 - Χιμαιρικες πρωτεϊνες l1 του ιου 16 ανθρωπινων θηλωματων που περιλαμβανουν l2 πεπτιδιο, ομοιαζοντα με ιο σωματιδια που παρασκευαζονται απο αυτες και μεθοδος παρασκευης των σωματιδιων - Google Patents
Χιμαιρικες πρωτεϊνες l1 του ιου 16 ανθρωπινων θηλωματων που περιλαμβανουν l2 πεπτιδιο, ομοιαζοντα με ιο σωματιδια που παρασκευαζονται απο αυτες και μεθοδος παρασκευης των σωματιδιωνInfo
- Publication number
- CY1109257T1 CY1109257T1 CY20091100595T CY091100595T CY1109257T1 CY 1109257 T1 CY1109257 T1 CY 1109257T1 CY 20091100595 T CY20091100595 T CY 20091100595T CY 091100595 T CY091100595 T CY 091100595T CY 1109257 T1 CY1109257 T1 CY 1109257T1
- Authority
- CY
- Cyprus
- Prior art keywords
- peptide
- dna sequence
- polypeptide
- juv
- similar
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20023—Virus like particles [VLP]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Biotechnology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Η εφεύρεση περιγράφει μέθοδο παρασκευής ενός χιμαιρικού L1 πολυπεπτιδίου ιού ανθρώπινων θηλωμάτων (HPV) που περιέχει ετερόλογο πεπτίδιο και συγκεκριμένα HPV L2 πεπτίδιο. Η μέθοδος περιλαμβάνει τα στάδια εισαγωγής μιας DNA αλληλουχίας που κωδικοποιεί το ετερόλογο πεπτίδιο εντός μιας DNA αλληλουχίας που κωδικοποιεί το L1 πολυπεπτίδιο, εισαγωγή της DNA αλληλουχίας που συμπεριλαμβάνει τις αλληλουχίες για το L1 πολυπεπτίδιο και ετερόλογο πεπτίδιο εντός ενός κυττάρου ξενιστή, όπου η DNA αλληλουχία μπορεί να εκφράζεται, προκαλώντας έκφραση της DNA αλληλουχίας και ανάκτηση του προκύπτοντος χιμαιρικού L1 πολυπεπτιδίου, το οποίο περιλαμβάνει το ετερόλογο πεπτίδιο. Τυπικά τα νουκλεοτίδια που κωδικοποιούν το ετερόλογο πεπτίδιο αντικαθιστούν τα νουκλεοτίδια του L1 πολυπεπτιδίου στο σημείο εισαγωγής. Η εφεύρεση επίσης περιγράφει φορέα για χρήση στη μέθοδο, κύτταρο ξενιστή που περιέχει το φορέα και ένα εμβόλιο που συμπεριλαμβάνει το χιμαιρικό HPV L1 πολυπεπτίδιο που παράγεται σύμφωνα με τη μέθοδο.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ZA200203957 | 2002-05-17 | ||
EP03727750A EP1506222B2 (en) | 2002-05-17 | 2003-05-19 | Chimeric human papillomavirus 16 l1 proteins comprising an l2 peptide, virus-like particles prepared therefrom and a method for preparing the particles |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1109257T1 true CY1109257T1 (el) | 2014-07-02 |
Family
ID=29550639
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20091100595T CY1109257T1 (el) | 2002-05-17 | 2009-06-04 | Χιμαιρικες πρωτεϊνες l1 του ιου 16 ανθρωπινων θηλωματων που περιλαμβανουν l2 πεπτιδιο, ομοιαζοντα με ιο σωματιδια που παρασκευαζονται απο αυτες και μεθοδος παρασκευης των σωματιδιων |
Country Status (13)
Country | Link |
---|---|
US (2) | US7407807B2 (el) |
EP (1) | EP1506222B2 (el) |
JP (2) | JP4614765B2 (el) |
AT (1) | ATE424409T1 (el) |
AU (1) | AU2003232951B2 (el) |
CA (1) | CA2486450C (el) |
CY (1) | CY1109257T1 (el) |
DE (1) | DE60326449D1 (el) |
DK (1) | DK1506222T3 (el) |
ES (1) | ES2323634T5 (el) |
PT (1) | PT1506222E (el) |
SI (1) | SI1506222T1 (el) |
WO (1) | WO2003097673A2 (el) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0228715D0 (en) * | 2002-12-09 | 2003-01-15 | Glaxosmithkline Biolog Sa | Vaccine |
CN103031310B (zh) | 2005-04-29 | 2018-09-14 | 开普敦大学 | 在植物中表达蛋白质 |
ES2310062B1 (es) | 2005-07-15 | 2009-11-13 | Bionostra, S.L. | Particulas pseudovirales vacias quimericas derivadas del virus causante de la enfermedad de la bursitis infecciosa (ibdv), procedimiento de obtencion y aplicaciones. |
CN1328287C (zh) * | 2005-12-29 | 2007-07-25 | 西安交通大学 | Hpv16 l1蛋白模拟肽及其用于制备hpv16诊断试剂和疫苗的用途 |
CA2703066A1 (en) * | 2007-10-22 | 2009-04-30 | University Of Rochester | Respiratory syncytial virus vaccine based on chimeric papillomavirus virus-like particles or capsomeres |
CN102497880A (zh) * | 2009-06-25 | 2012-06-13 | 葛兰素史密丝克莱恩生物有限公司 | 新的人***状瘤病毒(hpv)蛋白构建体及其在预防hpv疾病中的用途 |
US20120225090A1 (en) * | 2009-08-03 | 2012-09-06 | The Johns Hopkins University | Methods for enhancing antigen-specific immune responses |
JP6153866B2 (ja) | 2010-05-25 | 2017-06-28 | キアゲン ガイサーズバーグ アイエヌシー. | 迅速なハイブリッド捕捉アッセイ、及び関連する戦略的に切断されたプローブ |
MX355352B (es) * | 2011-12-01 | 2018-04-17 | Univ Cape Town | Particulas quimericas de vph. |
US20160175426A1 (en) * | 2013-07-16 | 2016-06-23 | University Of Louisville Research Foundation, Inc. | Compositions for mucusal delivery, useful for treating papillomavirus infections |
JP7017811B2 (ja) * | 2020-02-13 | 2022-02-09 | 国立研究開発法人農業・食品産業技術総合研究機構 | ウイルス様粒子及びその使用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5618536A (en) * | 1992-09-03 | 1997-04-08 | The United States Of America As Represented By The Department Of Health And Human Services | Chimeric papillomavirus-like particles |
CA2202090C (en) * | 1994-10-07 | 2012-04-17 | Lutz Gissmann | Papilloma virus-like particles, fusion proteins as well as processes for their production |
GB9621091D0 (en) * | 1996-10-09 | 1996-11-27 | Fondation Pour Le Perfectionem | Attenuated microorganisms strains and their uses |
US6228368B1 (en) † | 1997-10-06 | 2001-05-08 | Loyola University Of Chicago | Papilloma virus capsomere formulations and method of use |
US6926897B1 (en) † | 1998-03-24 | 2005-08-09 | Medigene Aktiengesellschaft | Medicament for the avoidance or treatment of papillomavirus-specific tumour |
DE19812941A1 (de) † | 1998-03-24 | 1999-10-07 | Medigene Ag | Arzneimittel zur Vermeidung oder Behandlung von Papillomavirusspezifischem Tumor |
AU753391B2 (en) * | 1998-08-14 | 2002-10-17 | Merck Sharp & Dohme Corp. | Protein delivery system using human papillomavirus virus-like particles |
GB9921146D0 (en) † | 1999-09-07 | 1999-11-10 | Smithkline Beecham Biolog | Novel composition |
DK2416798T3 (en) † | 2009-04-10 | 2018-01-08 | Univ Johns Hopkins | PAPILLOMAVIRUS-LIKE PARTICLES (VLP) AS WIDE-SPECIFIED VACCINES AGAINST HUMAN PAPILLOMAVIRUS (HPV) |
-
2003
- 2003-05-19 JP JP2004506346A patent/JP4614765B2/ja not_active Expired - Fee Related
- 2003-05-19 AT AT03727750T patent/ATE424409T1/de active
- 2003-05-19 DE DE60326449T patent/DE60326449D1/de not_active Expired - Lifetime
- 2003-05-19 DK DK03727750T patent/DK1506222T3/da active
- 2003-05-19 SI SI200331600T patent/SI1506222T1/sl unknown
- 2003-05-19 PT PT03727750T patent/PT1506222E/pt unknown
- 2003-05-19 ES ES03727750T patent/ES2323634T5/es not_active Expired - Lifetime
- 2003-05-19 US US10/514,878 patent/US7407807B2/en not_active Expired - Fee Related
- 2003-05-19 WO PCT/IB2003/001912 patent/WO2003097673A2/en active Application Filing
- 2003-05-19 AU AU2003232951A patent/AU2003232951B2/en not_active Ceased
- 2003-05-19 CA CA2486450A patent/CA2486450C/en not_active Expired - Fee Related
- 2003-05-19 EP EP03727750A patent/EP1506222B2/en not_active Expired - Lifetime
-
2008
- 2008-07-16 US US12/174,104 patent/US8163557B2/en not_active Expired - Lifetime
-
2009
- 2009-06-04 CY CY20091100595T patent/CY1109257T1/el unknown
-
2010
- 2010-06-16 JP JP2010137490A patent/JP2010263899A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
JP4614765B2 (ja) | 2011-01-19 |
ATE424409T1 (de) | 2009-03-15 |
AU2003232951A1 (en) | 2003-12-02 |
WO2003097673B1 (en) | 2004-04-22 |
EP1506222A2 (en) | 2005-02-16 |
JP2010263899A (ja) | 2010-11-25 |
PT1506222E (pt) | 2009-06-12 |
US20060035319A1 (en) | 2006-02-16 |
CA2486450A1 (en) | 2003-11-27 |
US20090047302A1 (en) | 2009-02-19 |
US7407807B2 (en) | 2008-08-05 |
WO2003097673A3 (en) | 2004-03-18 |
WO2003097673A2 (en) | 2003-11-27 |
DE60326449D1 (de) | 2009-04-16 |
US8163557B2 (en) | 2012-04-24 |
CA2486450C (en) | 2013-11-19 |
ES2323634T3 (es) | 2009-07-22 |
EP1506222B1 (en) | 2009-03-04 |
SI1506222T1 (sl) | 2009-10-31 |
EP1506222B2 (en) | 2012-05-23 |
DK1506222T3 (da) | 2009-07-06 |
JP2006507797A (ja) | 2006-03-09 |
AU2003232951B2 (en) | 2009-07-23 |
ES2323634T5 (es) | 2012-09-04 |
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