CY1108632T1 - Παραγωγα της 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline για θεραπεια της στειροτητας - Google Patents
Παραγωγα της 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline για θεραπεια της στειροτηταςInfo
- Publication number
- CY1108632T1 CY1108632T1 CY20081101479T CY081101479T CY1108632T1 CY 1108632 T1 CY1108632 T1 CY 1108632T1 CY 20081101479 T CY20081101479 T CY 20081101479T CY 081101479 T CY081101479 T CY 081101479T CY 1108632 T1 CY1108632 T1 CY 1108632T1
- Authority
- CY
- Cyprus
- Prior art keywords
- phenyl
- derivatives
- oxo
- hexahydroquinoline
- infertility
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Η παρούσα εφεύρεση αφορά σε παράγωγα της 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline σύμφωνα με τον τύπο I, ή ένα φαρμακευτικά αποδεκτό άλας του, όπου R1 είναι (1-6C)alkyl, (2-6C)alkenyl ή (2-6C)alkynyl,R2, R3 είναι ανεξάρτητα αλογόνο, (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (1-4C)-alkoxy, (3-4C)alkenyloxy ή (3-4C)alkynyloxy,R4 είναι φιανυλ ή (2-5C)heteroaryl, αμφότερα υποκαθίστανται από R7 και προαιρετικά υποκαθίστανται πάνω στον (ετερο)αρωματικό δακτύλιο από ένα ή περισσότερα υποκατάστατα που επιλέγονται από υδροξυ, αμινο, αλογονίδιο, νίτρο, τριφθορομεθυλ, κυανό, (1-4C)alkyl, (1-4C)alkoxy, (1-4C)alkylthio και (di)(1-4C)alkylamino. Η εφεύρεση επίσης αφορά σε φαρμακευτικές συνθέσεις που περιλαμβάνουν τα εν λόγω παράγωγα, καθώς επίσης στη χρήση αυτών των παράγωγων της 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline στη θεραπεία, ειδικότερα για τη θεραπεία της στειρότητας.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05103735 | 2005-05-04 | ||
| EP06743394A EP1881830B1 (en) | 2005-05-04 | 2006-05-02 | 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives the treatment of infertility |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1108632T1 true CY1108632T1 (el) | 2014-04-09 |
Family
ID=34939693
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20081101479T CY1108632T1 (el) | 2005-05-04 | 2008-12-22 | Παραγωγα της 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline για θεραπεια της στειροτητας |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US8022218B2 (el) |
| EP (1) | EP1881830B1 (el) |
| JP (1) | JP5129737B2 (el) |
| KR (1) | KR20080010426A (el) |
| CN (1) | CN101212973B (el) |
| AR (1) | AR057005A1 (el) |
| AT (1) | ATE410166T1 (el) |
| AU (1) | AU2006243868B2 (el) |
| BR (1) | BRPI0611120A2 (el) |
| CA (1) | CA2606683C (el) |
| CY (1) | CY1108632T1 (el) |
| DE (1) | DE602006003094D1 (el) |
| DK (1) | DK1881830T3 (el) |
| ES (1) | ES2314908T3 (el) |
| HK (1) | HK1110025A1 (el) |
| HR (1) | HRP20080667T3 (el) |
| IL (1) | IL186748A (el) |
| MX (1) | MX2007013751A (el) |
| NO (1) | NO20075617L (el) |
| NZ (1) | NZ562686A (el) |
| PE (1) | PE20061363A1 (el) |
| PL (1) | PL1881830T3 (el) |
| PT (1) | PT1881830E (el) |
| RS (1) | RS50707B (el) |
| RU (1) | RU2412170C2 (el) |
| SI (1) | SI1881830T1 (el) |
| TW (1) | TW200719894A (el) |
| UA (1) | UA92007C2 (el) |
| WO (1) | WO2006117368A1 (el) |
| ZA (1) | ZA200709090B (el) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA92008C2 (en) * | 2005-05-04 | 2010-09-27 | Н.В. Органон | 4-PHENYL-5-OXO-l,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY |
| UA92009C2 (ru) * | 2005-05-04 | 2010-09-27 | Н.В. Органон | Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодия |
| DK1879866T3 (da) * | 2005-05-04 | 2011-06-06 | Organon Nv | Dihydropyridinderivater |
| TW200944523A (en) | 2008-02-08 | 2009-11-01 | Organon Nv | (Dihydro)pyrrolo[2,1-a]isoquinolines |
| US8071587B2 (en) | 2009-05-27 | 2011-12-06 | N. V. Organon | (Dihydro)imidazoiso[5,1-A]quinolines |
| TW201116531A (en) | 2009-07-29 | 2011-05-16 | Organon Nv | Ring-annulated dihydropyrrolo[2,1-a]isoquinolines |
| US8431564B2 (en) | 2009-07-29 | 2013-04-30 | Merck Sharp & Dohme B.V. | Ring-annulated dihydropyrrolo[2,1-α]isoquinolines |
| TW201116515A (en) | 2009-07-31 | 2011-05-16 | Organon Nv | Dihydrobenzoindazoles |
| EP2694472B1 (en) | 2011-04-05 | 2020-03-11 | Takeda Pharmaceutical Company Limited | Sulfonamide derivative and use thereof |
| EP2925739A4 (en) * | 2012-11-28 | 2016-07-27 | Stichting Dienst Landbouwkundi | SUBSTITUTED DIHYDROPYRTOINS FOR PLANTS WITH SOMATIC EMBRYOGENESIS I |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1070162B (de) | 1959-12-03 | Farbwerke Hoechst Aktiengesellschaft vormals Meister Lucius &. Brüning, Frankfurt/M | Verfahren zur Herstellung von 5 - Brom - 3 - nitro - 4 - hydroxybenzaldehyd bzw. 5 - Chlor - 3 - nitro - 4 - hydroxybenzaldehyd | |
| GB9318935D0 (en) * | 1992-10-20 | 1993-10-27 | Zeneca Ltd | Heterocyclic derivatives |
| US5455253A (en) * | 1992-10-20 | 1995-10-03 | Zeneca Limited | Heterocyclic derivatives |
| DE4430639A1 (de) * | 1994-08-29 | 1996-03-07 | Bayer Ag | Verwendung von 5-substituierten Pyridin- und Hexahydrochinolin-3-carbonsäurederivaten |
| GB9515445D0 (en) * | 1995-07-27 | 1995-09-27 | Pharmacia Spa | Dihydropyridine and pyridine derivatives and process for their preparation |
| EP0876349B1 (en) * | 1995-10-19 | 2002-09-11 | Takeda Chemical Industries, Ltd. | Quinoline derivatives as gnrh antagonists |
| US6593335B1 (en) * | 1997-12-18 | 2003-07-15 | Abbott Laboratories | Potassium channel openers |
| JP4511042B2 (ja) | 1998-08-07 | 2010-07-28 | メルク セローノ ソシエテ アノニム | 不妊症の治療のためのｆｓｈ模倣物 |
| JP2004505051A (ja) | 2000-07-27 | 2004-02-19 | スミスクライン ビーチャム コーポレーション | 卵胞刺激ホルモン活性のアゴニスト |
| ES2260458T3 (es) * | 2001-07-02 | 2006-11-01 | Akzo Nobel N.V. | Derivados de tetrahidroquinolina. |
| JP2003026630A (ja) | 2001-07-13 | 2003-01-29 | Taoka Chem Co Ltd | カラーカプラー中間体用カルボン酸クロリド類の製造法 |
| TWI322012B (en) | 2002-12-20 | 2010-03-21 | Organon Nv | Tetrahydroquinoline derivatives |
| UA92008C2 (en) * | 2005-05-04 | 2010-09-27 | Н.В. Органон | 4-PHENYL-5-OXO-l,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY |
| DK1879866T3 (da) * | 2005-05-04 | 2011-06-06 | Organon Nv | Dihydropyridinderivater |
| UA92009C2 (ru) * | 2005-05-04 | 2010-09-27 | Н.В. Органон | Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодия |
-
2006
- 2006-02-05 UA UAA200711802A patent/UA92007C2/ru unknown
- 2006-05-02 WO PCT/EP2006/061972 patent/WO2006117368A1/en active Application Filing
- 2006-05-02 US US11/912,736 patent/US8022218B2/en active Active
- 2006-05-02 CA CA2606683A patent/CA2606683C/en not_active Expired - Fee Related
- 2006-05-02 AU AU2006243868A patent/AU2006243868B2/en not_active Ceased
- 2006-05-02 KR KR1020077026919A patent/KR20080010426A/ko not_active Application Discontinuation
- 2006-05-02 PL PL06743394T patent/PL1881830T3/pl unknown
- 2006-05-02 AT AT06743394T patent/ATE410166T1/de active
- 2006-05-02 MX MX2007013751A patent/MX2007013751A/es active IP Right Grant
- 2006-05-02 SI SI200630157T patent/SI1881830T1/sl unknown
- 2006-05-02 BR BRPI0611120-3A patent/BRPI0611120A2/pt not_active IP Right Cessation
- 2006-05-02 JP JP2008509434A patent/JP5129737B2/ja not_active Expired - Fee Related
- 2006-05-02 CN CN2006800237595A patent/CN101212973B/zh not_active Expired - Fee Related
- 2006-05-02 RS RSP-2008/0582A patent/RS50707B/sr unknown
- 2006-05-02 EP EP06743394A patent/EP1881830B1/en active Active
- 2006-05-02 DK DK06743394T patent/DK1881830T3/da active
- 2006-05-02 ES ES06743394T patent/ES2314908T3/es active Active
- 2006-05-02 RU RU2007144989/04A patent/RU2412170C2/ru not_active IP Right Cessation
- 2006-05-02 PT PT06743394T patent/PT1881830E/pt unknown
- 2006-05-02 DE DE602006003094T patent/DE602006003094D1/de active Active
- 2006-05-02 NZ NZ562686A patent/NZ562686A/en not_active IP Right Cessation
- 2006-05-03 PE PE2006000464A patent/PE20061363A1/es not_active Application Discontinuation
- 2006-05-03 TW TW095115774A patent/TW200719894A/zh unknown
- 2006-05-03 AR ARP060101779A patent/AR057005A1/es unknown
-
2007
- 2007-10-18 IL IL186748A patent/IL186748A/en not_active IP Right Cessation
- 2007-10-22 ZA ZA200709090A patent/ZA200709090B/xx unknown
- 2007-11-06 NO NO20075617A patent/NO20075617L/no not_active Application Discontinuation
-
2008
- 2008-04-22 HK HK08104451A patent/HK1110025A1/xx not_active IP Right Cessation
- 2008-12-19 HR HR20080667T patent/HRP20080667T3/xx unknown
- 2008-12-22 CY CY20081101479T patent/CY1108632T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1108632T1 (el) | Παραγωγα της 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline για θεραπεια της στειροτητας | |
| CY1122863T1 (el) | Φαρμακευτικη συνθεση που περιεχει γλυκοπυρρολικο και εναν αγωνιστη βητα2 αδρενοϋποδοχεα | |
| CY1120081T1 (el) | Παραγωγα hydroxybenzamide σαν παραγοντες καταστολης της hsp90 | |
| CY1113324T1 (el) | Υποκατεστημενα αμιδικα παραγωγα ως αναστολεις πρωτεϊνικων κινασων | |
| CY1118723T1 (el) | Ενωσεις βενζοθειαζολιου και αζαβενζοθειαζολιου χρησιμες ως αναστολεiς κινασης | |
| CY1117719T1 (el) | Παραγωγα αμινοπυριμιδινης ως διαμορφωτες της lrrk2 | |
| CY1116119T1 (el) | Παραγωγα ισοξαζολο-πυριδινης | |
| CY1122182T1 (el) | Ανοσοκατασταλτικες φαρμακοτεχνικες μορφες | |
| EA201690019A1 (ru) | Производное аминотриазина и содержащая его фармацевтическая композиция | |
| CY1108019T1 (el) | Ενωσεις πυριμιδινης | |
| CY1113395T1 (el) | Σταθερη φαρμακευτικη συνθεση που περιεχει πυριμιδινη-σουλφαμιδη | |
| CY1113538T1 (el) | Παραγωγα της 5-αμινο-2,4,7-τριοξο-3,4,7,8-τετραϋδρο-2η-πυριδο[2,3-d] πυριμιδινης και παρομοιες ενωσεις για την αγωγη του καρκινου | |
| CY1114932T1 (el) | Αντιπαρασιτικοι παραγοντες | |
| PE20040155A1 (es) | Derivados aminoinazoles, procedimiento de preparacion e intermedios de este procedimiento a titulo de medicamentos y composiciones farmaceuticas que los contienen | |
| CY1111876T1 (el) | Νεες πυρρολες με υπολiπiδaiμiκες και υποχοληστερολαιμικες δραστικοτητες, μεθοδος για την παρασκευη αυτων και φαρμακευτικες συνθεσεις που τις περιεχουν και η χρηση αυτων στην ιατρικη | |
| PL402388A1 (pl) | Pochodna pirymidyny, jej zastosowanie i kompozycja farmaceutyczna ja zawierajaca | |
| CY1106679T1 (el) | Αζαδικυκλικες ετεροκυκλικες ενωσεις ως τροποποιητες κανναβινοειδους υποδοχεα | |
| EA201101089A1 (ru) | Производные оксадиазола в качестве агонистов рецептора s1p1 | |
| CY1115643T1 (el) | Διεγερτης νευρογενεσης ή θεραπευτικος παραγων νευροπαθειας που περιλαμβανει παραγωγα αλκυλ αιθερα ή αλας αυτου | |
| NO20054135L (no) | Kipolinon/benzoksazin derivater og anvendelser derav | |
| CY1111450T1 (el) | Ενωσεις που αναστελλουν τη φλεγμονη | |
| TW200612936A (en) | Indole derivatives | |
| EA200701780A1 (ru) | Противоопухолевое средство | |
| EA202192019A1 (ru) | Производные 3-(1-оксо-5-(пиперидин-4-ил)изоиндолин-2-ил)пиперидин-2,6-диона и пути их применения | |
| CY1105631T1 (el) | Υποκατεστημενα παραγωγα καρβοστυριλης ως αγωνιστες 5-ητ1α υποτυπου δεκτη |