CY1108306T1 - Αναστολεις αζαϊνδολιου των mtp και apob - Google Patents
Αναστολεις αζαϊνδολιου των mtp και apobInfo
- Publication number
- CY1108306T1 CY1108306T1 CY20081100933T CY081100933T CY1108306T1 CY 1108306 T1 CY1108306 T1 CY 1108306T1 CY 20081100933 T CY20081100933 T CY 20081100933T CY 081100933 T CY081100933 T CY 081100933T CY 1108306 T1 CY1108306 T1 CY 1108306T1
- Authority
- CY
- Cyprus
- Prior art keywords
- mtp
- apob
- ajaidolo
- suspensions
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Η παρούσα εφεύρεση αφορά σε ενώσεις που έχουν ως βάση το 7-αζαϊνδόλιο, σε μεθόδους για την παρασκευή αυτών, σε φαρμακευτικές συνθέσεις οι οποίες τις περιέχουν και στη χρήση αυτών στην παρασκευή φαρμακευτικών προϊόντων τα οποία είναι χρήσιμα ως αναστολείς της MTP και της έκκρισης ApoB.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0408302A FR2873694B1 (fr) | 2004-07-27 | 2004-07-27 | Nouveaux aza-indoles inhibiteurs de la mtp et apob |
EP05754288A EP1771446B1 (en) | 2004-07-27 | 2005-06-28 | Azaindole inhibitors of mtp and apob |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1108306T1 true CY1108306T1 (el) | 2014-02-12 |
Family
ID=34948943
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20081100933T CY1108306T1 (el) | 2004-07-27 | 2008-09-02 | Αναστολεις αζαϊνδολιου των mtp και apob |
Country Status (16)
Country | Link |
---|---|
US (1) | US7838533B2 (el) |
EP (1) | EP1771446B1 (el) |
JP (1) | JP5161569B2 (el) |
AR (1) | AR050436A1 (el) |
AT (1) | ATE398126T1 (el) |
AU (1) | AU2005266662B2 (el) |
CA (1) | CA2575223C (el) |
CY (1) | CY1108306T1 (el) |
DE (1) | DE602005007494D1 (el) |
DK (1) | DK1771446T3 (el) |
ES (1) | ES2308510T3 (el) |
FR (1) | FR2873694B1 (el) |
PL (1) | PL1771446T3 (el) |
PT (1) | PT1771446E (el) |
SI (1) | SI1771446T1 (el) |
WO (1) | WO2006010423A2 (el) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3431602A1 (en) | 2006-04-03 | 2019-01-23 | Roche Innovation Center Copenhagen A/S | Pharmaceutical composition comprising anti-mirna antisense oligonucleotides |
JP5814505B2 (ja) | 2006-04-03 | 2015-11-17 | ロシュ・イノベーション・センター・コペンハーゲン・アクティーゼルスカブRoche Innovation Center Copenhagen A/S | antimiRNAアンチセンスオリゴヌクレオチドを含む医薬組成物 |
AU2007283113A1 (en) | 2006-08-08 | 2008-02-14 | Sanofi-Aventis | Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, processes for preparing them, medicaments comprising these compounds, and their use |
DE102007005045B4 (de) | 2007-01-26 | 2008-12-18 | Sanofi-Aventis | Phenothiazin Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
AU2008228243B2 (en) | 2007-03-22 | 2014-05-15 | Santaris Pharma A/S | RNA antagonist compounds for the inhibition of Apo-B100 expression |
DK2149605T3 (da) | 2007-03-22 | 2013-09-30 | Santaris Pharma As | Korte RNA antagonist forbindelser til modulering af det ønskede mRNA |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
AU2008306327B2 (en) | 2007-10-04 | 2014-05-15 | Roche Innovation Center Copenhagen A/S | Micromirs |
DE102007054497B3 (de) | 2007-11-13 | 2009-07-23 | Sanofi-Aventis Deutschland Gmbh | Neue kristalline Diphenylazetidinonhydrate und Verfahren zu deren Herstellung |
US8404659B2 (en) | 2008-03-07 | 2013-03-26 | Santaris Pharma A/S | Pharmaceutical compositions for treatment of MicroRNA related diseases |
UY31968A (es) | 2008-07-09 | 2010-01-29 | Sanofi Aventis | Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos |
ES2541442T3 (es) | 2008-08-01 | 2015-07-20 | Roche Innovation Center Copenhagen A/S | Modulación mediada por microARN de factores estimulantes de colonias |
WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
WO2010122538A1 (en) | 2009-04-24 | 2010-10-28 | Santaris Pharma A/S | Pharmaceutical compositions for treatment of hcv patients that are non-responders to interferon |
US8563528B2 (en) | 2009-07-21 | 2013-10-22 | Santaris Pharma A/S | Antisense oligomers targeting PCSK9 |
CA2771278A1 (en) | 2009-08-26 | 2011-03-03 | Sanofi | Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use |
EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
WO2012120052A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
US8809325B2 (en) | 2011-03-08 | 2014-08-19 | Sanofi | Benzyl-oxathiazine derivatives substituted with adamantane and noradamantane, medicaments containing said compounds and use thereof |
WO2012120058A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
US8828994B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
EP2683699B1 (de) | 2011-03-08 | 2015-06-24 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120057A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
WO2012120053A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
US8809324B2 (en) | 2011-03-08 | 2014-08-19 | Sanofi | Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof |
JP2014518223A (ja) * | 2011-06-20 | 2014-07-28 | アルツハイマーズ・インスティテュート・オブ・アメリカ・インコーポレイテッド | 化合物とその治療用途 |
CN112263682A (zh) | 2013-06-27 | 2021-01-26 | 罗氏创新中心哥本哈根有限公司 | 靶向pcsk9的反义寡聚体和缀合物 |
TW202039481A (zh) | 2018-12-21 | 2020-11-01 | 美商西建公司 | Ripk2之噻吩并吡啶抑制劑 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3362956A (en) * | 1965-08-19 | 1968-01-09 | Sterling Drug Inc | 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines |
US3511841A (en) * | 1967-05-29 | 1970-05-12 | Sterling Drug Inc | 1-((4-,5-,6-,and 7-azaindolyl)-lower-alkyl)- 4-substituted-piperazines |
US4939159A (en) * | 1986-09-10 | 1990-07-03 | Sandoz Pharm. Corp. | Azaindole derivatives useful as cholesterol biosynthesis inhibitors |
DE4435477A1 (de) * | 1994-10-04 | 1996-04-11 | Bayer Ag | Cycloalkano-indol- und -azaindol-derivate |
AU2002307839B2 (en) | 2001-06-28 | 2006-03-16 | Zoetis P Llc | Triamide-substituted indoles, benzofuranes and benzothiophenes as inhibitors of microsomal triglyceride transfer protein (MTP) and/or apolipoprotein B (Apo B) secretion |
US6861440B2 (en) * | 2001-10-26 | 2005-03-01 | Hoffmann-La Roche Inc. | DPP IV inhibitors |
AU2003241907A1 (en) * | 2002-05-31 | 2003-12-19 | Yamanouchi Pharmaceutical Co., Ltd. | Tetrahydropyran derivative |
DE10229777A1 (de) | 2002-07-03 | 2004-01-29 | Bayer Ag | Indolin-Phenylsulfonamid-Derivate |
JP4737495B2 (ja) * | 2004-01-14 | 2011-08-03 | 塩野義製薬株式会社 | エリスロマイシン誘導体 |
-
2004
- 2004-07-27 FR FR0408302A patent/FR2873694B1/fr not_active Expired - Fee Related
-
2005
- 2005-06-28 SI SI200530353T patent/SI1771446T1/sl unknown
- 2005-06-28 US US11/658,596 patent/US7838533B2/en not_active Expired - Fee Related
- 2005-06-28 AT AT05754288T patent/ATE398126T1/de active
- 2005-06-28 PL PL05754288T patent/PL1771446T3/pl unknown
- 2005-06-28 WO PCT/EP2005/006930 patent/WO2006010423A2/en active IP Right Grant
- 2005-06-28 EP EP05754288A patent/EP1771446B1/en not_active Not-in-force
- 2005-06-28 ES ES05754288T patent/ES2308510T3/es active Active
- 2005-06-28 CA CA2575223A patent/CA2575223C/en not_active Expired - Fee Related
- 2005-06-28 PT PT05754288T patent/PT1771446E/pt unknown
- 2005-06-28 JP JP2007522937A patent/JP5161569B2/ja not_active Expired - Fee Related
- 2005-06-28 AU AU2005266662A patent/AU2005266662B2/en not_active Ceased
- 2005-06-28 DK DK05754288T patent/DK1771446T3/da active
- 2005-06-28 DE DE602005007494T patent/DE602005007494D1/de active Active
- 2005-07-27 AR ARP050103117A patent/AR050436A1/es unknown
-
2008
- 2008-09-02 CY CY20081100933T patent/CY1108306T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP1771446B1 (en) | 2008-06-11 |
WO2006010423A2 (en) | 2006-02-02 |
US20090036481A1 (en) | 2009-02-05 |
ATE398126T1 (de) | 2008-07-15 |
WO2006010423A3 (en) | 2006-03-02 |
FR2873694A1 (fr) | 2006-02-03 |
CA2575223A1 (en) | 2006-02-02 |
EP1771446A2 (en) | 2007-04-11 |
AR050436A1 (es) | 2006-10-25 |
US7838533B2 (en) | 2010-11-23 |
CA2575223C (en) | 2013-08-06 |
JP5161569B2 (ja) | 2013-03-13 |
FR2873694B1 (fr) | 2006-12-08 |
AU2005266662A1 (en) | 2006-02-02 |
JP2008508198A (ja) | 2008-03-21 |
AU2005266662B2 (en) | 2011-04-21 |
DE602005007494D1 (de) | 2008-07-24 |
SI1771446T1 (sl) | 2008-10-31 |
ES2308510T3 (es) | 2008-12-01 |
DK1771446T3 (da) | 2008-09-22 |
PL1771446T3 (pl) | 2008-10-31 |
PT1771446E (pt) | 2008-09-17 |
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