CY1107993T1 - Διαγνωση tauoπαθειων προσδιοριζοντας την αναλογια tau/φωσφο-tau - Google Patents
Διαγνωση tauoπαθειων προσδιοριζοντας την αναλογια tau/φωσφο-tauInfo
- Publication number
- CY1107993T1 CY1107993T1 CY20071100047T CY071100047T CY1107993T1 CY 1107993 T1 CY1107993 T1 CY 1107993T1 CY 20071100047 T CY20071100047 T CY 20071100047T CY 071100047 T CY071100047 T CY 071100047T CY 1107993 T1 CY1107993 T1 CY 1107993T1
- Authority
- CY
- Cyprus
- Prior art keywords
- tau
- phospho
- diagnosis
- tauopathies
- analogy
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
Abstract
Η παρούσα εφεύρεση δίδει μία μέθοδο για τη διάγνωση των tauοπαθειών σ' ένα άτομο και/ή για τη διαφορική διάγνωση μίας tauοπάθειας έναντι μίας μη-tauοπάθειας με βάση την ανίχνευση της αναλογίας της φωσφο-tau(181)/ολική tau στο εν λόγω άτομο. Η παρούσα εφεύρεση περαιτέρω δίδει ένα φωσφο-πεπτίδιο για την τυποποίηση σε μία μέθοδο της εφεύρεσης.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00870008 | 2000-01-24 | ||
US17839100P | 2000-01-27 | 2000-01-27 | |
EP00870280 | 2000-11-22 | ||
EP01909655A EP1250600B1 (en) | 2000-01-24 | 2001-01-18 | Diagnosis of tauopathies determining tau/phospho-tau ratio |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1107993T1 true CY1107993T1 (el) | 2013-09-04 |
Family
ID=27223742
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20071100047T CY1107993T1 (el) | 2000-01-24 | 2007-01-11 | Διαγνωση tauoπαθειων προσδιοριζοντας την αναλογια tau/φωσφο-tau |
Country Status (13)
Country | Link |
---|---|
US (2) | US6680173B2 (el) |
EP (1) | EP1250600B1 (el) |
JP (1) | JP5247963B2 (el) |
AT (1) | ATE342509T1 (el) |
AU (1) | AU777837B2 (el) |
BR (1) | BR0107851A (el) |
CA (1) | CA2397991C (el) |
CY (1) | CY1107993T1 (el) |
DE (2) | DE1250600T1 (el) |
DK (1) | DK1250600T3 (el) |
ES (1) | ES2274869T3 (el) |
HK (1) | HK1048513B (el) |
WO (1) | WO2001055725A2 (el) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030162230A1 (en) * | 2000-09-27 | 2003-08-28 | Reagan Kevin J. | Method for quantifying phosphokinase activity on proteins |
JP4681175B2 (ja) * | 2001-09-28 | 2011-05-11 | 三菱化学メディエンス株式会社 | 播種性血管内凝固症候群及びその発症前段階を検出する方法 |
JP4393382B2 (ja) * | 2002-08-14 | 2010-01-06 | 三菱化学株式会社 | 中枢性タウ蛋白質特異的抗体 |
EP1606404A4 (en) * | 2003-03-12 | 2006-04-12 | Assay Designs Inc | PHOSPHOKINASETEST |
US7619059B2 (en) * | 2003-07-29 | 2009-11-17 | Life Technologies Corporation | Bimolecular optical probes |
US7727752B2 (en) * | 2003-07-29 | 2010-06-01 | Life Technologies Corporation | Kinase and phosphatase assays |
CA2445420A1 (en) * | 2003-07-29 | 2005-01-29 | Invitrogen Corporation | Kinase and phosphatase assays |
US7238788B2 (en) * | 2004-02-18 | 2007-07-03 | University Of Iowa Foundation | Antibodies to phosphorylated tau, methods of making and methods of use |
JP4730584B2 (ja) | 2004-12-06 | 2011-07-20 | 東亞合成株式会社 | 抗菌ペプチド及びその利用 |
WO2007068105A1 (en) * | 2005-12-12 | 2007-06-21 | Robarts Research Institute | Method of diagnosing amyotrophic lateral sclerosis |
EP2326339A4 (en) * | 2008-05-21 | 2012-06-20 | Neurotez Inc | METHOD FOR TREATING PROGRESSIVE COGNITIVE DISORDER IN CONNECTION WITH NEUROFIBRILLARY TANGLES |
US8648044B2 (en) * | 2009-09-24 | 2014-02-11 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | FKBP52-tau interaction as a novel therapeutical target for treating the neurological disorders involving tau dysfunction |
WO2011109112A2 (en) * | 2010-03-05 | 2011-09-09 | Albert Einstein College Of Medicine Of Yeshiva University | Method of detecting tau protein and tau fragments in serum |
US20130052669A1 (en) * | 2010-04-30 | 2013-02-28 | Amanda G. Paulovich | Compositions and methods for reliably detecting and/or measuring the amount of a modified target protein in a sample |
CA2826286C (en) * | 2011-01-31 | 2021-09-21 | Intellect Neurosciences Inc. | Treatment of tauopathies |
WO2012142301A2 (en) | 2011-04-12 | 2012-10-18 | Quanterix Corporation | Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury |
GB201111361D0 (en) * | 2011-07-04 | 2011-08-17 | Nordic Bioscience As | Biochemical markers for neurodegenerative conditions |
BR112015003326A2 (pt) | 2012-08-16 | 2017-07-04 | Ipierian Inc | métodos de tratamento de uma tauopatia |
EP2893042B1 (en) * | 2012-09-05 | 2018-02-14 | Emory University | Diagnostic testing in dementia and methods related thereto |
US8980270B2 (en) | 2013-01-18 | 2015-03-17 | Ipierian, Inc. | Methods of treating a tauopathy |
ES2800827T3 (es) | 2013-06-10 | 2021-01-04 | Ipierian Inc | Procedimientos de tratamiento de una tauopatía |
SI3083680T1 (sl) | 2013-12-20 | 2020-06-30 | F. Hoffmann-La Roche Ag | Humanizirana protitelesa proti beljakovini Tau(pS422) in postopki uporabe |
JP2017512751A (ja) | 2014-02-14 | 2017-05-25 | アイピエリアン,インコーポレイティド | タウペプチド、抗タウ抗体、およびそれらの使用方法 |
CN106605146B (zh) * | 2014-04-08 | 2020-07-28 | 佛罗里达大学研究基金会有限公司 | 用于中枢神经***的急性、亚急性和慢性创伤性损伤的蛋白质标志物 |
AR100978A1 (es) | 2014-06-26 | 2016-11-16 | Hoffmann La Roche | LANZADERAS CEREBRALES DE ANTICUERPO HUMANIZADO ANTI-Tau(pS422) Y USOS DE LAS MISMAS |
DE102014013571A1 (de) * | 2014-09-18 | 2016-03-24 | Aj Roboscreen Gmbh | Monoklonaler Antikörper gegen humanes TAU-Protein |
CN113929779A (zh) | 2015-06-24 | 2022-01-14 | 豪夫迈·罗氏有限公司 | 人源化的抗-Tau(pS422)抗体和使用方法 |
KR102033776B1 (ko) * | 2017-10-31 | 2019-10-17 | 가천대학교 산학협력단 | 타우 단백질의 발현수준을 측정하는 제제를 포함하는 알츠하이머 중증도 진단용 조성물 및 이를 이용한 알츠하이머 중증도의 진단방법 |
JOP20200215A1 (ar) | 2018-03-05 | 2020-09-03 | Janssen Pharmaceutica Nv | الأجسام المضادة لـ PHF-Tau المضاد واستخداماتها |
EP3885362A4 (en) * | 2018-11-22 | 2022-08-17 | Fujirebio Inc. | ANTIBODY CONJUGATE |
WO2020193500A1 (en) * | 2019-03-28 | 2020-10-01 | H. Lundbeck A/S | Use of a ps396 assay to diagnose tauophaties |
US11155609B2 (en) | 2019-04-05 | 2021-10-26 | TauC3 Biologies Limited | Anti-TAUC3 antibodies and uses thereof |
BR112021021062A2 (pt) * | 2019-05-31 | 2021-12-14 | Lilly Co Eli | Compostos e métodos que alvejam tau humano |
CA3168823A1 (en) * | 2020-02-05 | 2021-08-12 | Sumitomo Pharma Co., Ltd. | Determination agent and determination method for tauopathy and dementia-related diseases |
WO2023135201A1 (en) * | 2022-01-12 | 2023-07-20 | Gtinvent Limited | Method for detecting a tau protein fragment in a sample |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0600951A4 (en) * | 1991-08-01 | 1996-10-30 | Paul H Voorheis | Diagnostic method for alzheimer's disease. |
DK0673418T3 (da) * | 1992-12-14 | 1999-03-01 | Innogenetics Nv | Monoklonale antistoffer rettet mod mikrotubulusassocieret tau-protein, hybridomaer, der secernerer disse antistoffer, antig |
JPH06239899A (ja) * | 1993-02-12 | 1994-08-30 | Teijin Ltd | ヒトタウ蛋白に対する抗体、並びに該抗体を利用する体液中のヒトタウ蛋白の測定方法 |
EP0737208B1 (en) * | 1993-12-21 | 2006-08-02 | Innogenetics N.V. | Monoclonal antibodies specific for phf-tau, hybridomas secreting them, antigen recognition by these antibodies and their applications |
JPH10506381A (ja) * | 1994-07-29 | 1998-06-23 | イノジェネティックス・ナムローゼ・フェンノートシャップ | 特定のサブクラスまたは形態のホスホリレーションされたtauのエピトープに特異的なモノクローナル抗体、それらを分泌するハイブリドーマ、これらの抗体の抗原認識およびそれらの応用 |
WO1997034145A1 (fr) * | 1996-03-13 | 1997-09-18 | Mitsubishi Chemical Corporation | Anticorps a proteine tau antiphosphorylee et procede de detection de la maladie d'alzheimer l'utilisant |
WO1999062548A1 (en) * | 1998-06-01 | 1999-12-09 | Advanced Research And Technology Institute | Methods and compositions for diagnosing tauopathies |
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2001
- 2001-01-18 DE DE1250600T patent/DE1250600T1/de active Pending
- 2001-01-18 JP JP2001555812A patent/JP5247963B2/ja not_active Expired - Lifetime
- 2001-01-18 CA CA2397991A patent/CA2397991C/en not_active Expired - Lifetime
- 2001-01-18 EP EP01909655A patent/EP1250600B1/en not_active Expired - Lifetime
- 2001-01-18 ES ES01909655T patent/ES2274869T3/es not_active Expired - Lifetime
- 2001-01-18 DK DK01909655T patent/DK1250600T3/da active
- 2001-01-18 WO PCT/EP2001/000560 patent/WO2001055725A2/en active IP Right Grant
- 2001-01-18 BR BR0107851-8A patent/BR0107851A/pt not_active Application Discontinuation
- 2001-01-18 AU AU37319/01A patent/AU777837B2/en not_active Expired
- 2001-01-18 AT AT01909655T patent/ATE342509T1/de active
- 2001-01-18 DE DE60123752T patent/DE60123752T2/de not_active Expired - Lifetime
- 2001-01-24 US US09/769,180 patent/US6680173B2/en not_active Expired - Lifetime
-
2002
- 2002-11-15 HK HK02108310.4A patent/HK1048513B/zh not_active IP Right Cessation
-
2003
- 2003-10-09 US US10/682,103 patent/US7387879B2/en not_active Expired - Lifetime
-
2007
- 2007-01-11 CY CY20071100047T patent/CY1107993T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
US20030194742A1 (en) | 2003-10-16 |
DK1250600T3 (da) | 2007-02-05 |
US7387879B2 (en) | 2008-06-17 |
JP5247963B2 (ja) | 2013-07-24 |
EP1250600B1 (en) | 2006-10-11 |
AU3731901A (en) | 2001-08-07 |
HK1048513B (zh) | 2007-12-07 |
ATE342509T1 (de) | 2006-11-15 |
WO2001055725A3 (en) | 2001-12-20 |
WO2001055725A2 (en) | 2001-08-02 |
ES2274869T3 (es) | 2007-06-01 |
HK1048513A1 (en) | 2003-04-04 |
BR0107851A (pt) | 2002-10-29 |
CA2397991A1 (en) | 2001-08-02 |
DE60123752D1 (de) | 2006-11-23 |
US6680173B2 (en) | 2004-01-20 |
JP2003521499A (ja) | 2003-07-15 |
CA2397991C (en) | 2017-10-24 |
DE60123752T2 (de) | 2007-08-23 |
DE1250600T1 (de) | 2003-03-06 |
US20040091942A1 (en) | 2004-05-13 |
AU777837B2 (en) | 2004-11-04 |
EP1250600A2 (en) | 2002-10-23 |
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