CY1107903T1 - Παραγωγα ακυλαμινοθειαζολης και η χρηση τους ως αναστολεις του βητα-αμυλοειδους - Google Patents
Παραγωγα ακυλαμινοθειαζολης και η χρηση τους ως αναστολεις του βητα-αμυλοειδουςInfo
- Publication number
- CY1107903T1 CY1107903T1 CY20081100273T CY081100273T CY1107903T1 CY 1107903 T1 CY1107903 T1 CY 1107903T1 CY 20081100273 T CY20081100273 T CY 20081100273T CY 081100273 T CY081100273 T CY 081100273T CY 1107903 T1 CY1107903 T1 CY 1107903T1
- Authority
- CY
- Cyprus
- Prior art keywords
- group
- substituted
- cycloalkyl
- alkyl
- phenyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
Ένωση η οποία αντιστοιχεί στον γενικό χημικό τύπο (I) : το R1 αντιπροσωπεύει ένα C1-6 αλκύλιο υποκατεστημένο, ένα C3-7 - κυκλοαλκυλ, ένα θειοφεν, ένα βενζοθειοφεν, ένα πυριδινυλ, ένα φουρανυλ ή ένα φαινυλ · οι ομάδες φαινυλ έχουν υποκατασταθεί· το R2 και το R2' αντιπροσωπεύουν ανεξάρτητα το ένα από το άλλο ένα άτομο υδρογόνου, ένα άτομο αλογόνου, ένα υδροξύ, ένα C1-3 αλκοξύ, ένα C1-3 αλκυλ, ένα C3-7 κυκλοαλκυλ, μια ομάδα Ο-C(Ο)-C1-6 αλκυλ, ή το R2 και το R2' σχηματίζουν μαζί μια ομάδα οξο· το R3 αντιπροσωπεύει ένα άτομο υδρογόνου ή ένα C1-6 αλκυλ το οποίο έχει υποκατασταθεί από ένα υδροξύ ή ένα C1-3 αλκοξύ· το R4 και το R5 αντιπροσωπεύουν, ανεξάρτητα το ένα από το άλλο ένα άτομο υδρογόνου, ένα C1-7 αλκυλ, το οποίο έχει υποκατασταθεί, ένα C3-7 κυκλοαλκυλ, ένα φαινυλ, ένα ναφθυλ ή ένα - C ( Χ ) R6· οι ομάδες C3-7 κυκλοαλκυλ και φαινυλ έχουν υποκατασταθεί· υπό την προϋπόθεση ότι τουλάχιστον μια ομάδα R4 ή R5 αντιπροσωπεύει μια ομάδα - C(X)R6· το X αντιπροσωπεύει ένα άτομο οξυγόνου ή ένα άτομο θείου· το R6 αντιπροσωπεύει μια ομάδα C1-6 αλκοξύ, ένα υδροξύ ή μια ομάδα - NR7R8 · η ομάδα C1-6 αλκοξύ έχει υποκατασταθεί από ένα φαινυλ · το R7 και το R8 αντιπροσωπεύουν, ανεξάρτητα το ένα από το άλλο ένα άτομο υδρογόνου, μια ομάδα C1-6 αλκυλ, το οποίο έχει υποκατασταθεί, ένα C3-7 κυκλοαλκυλ, ένα C1-6 αλκοξύ ή ένα φαινυλ· ή το R7 και το R8 μαζί με το άτομο του αζώτου που τα φέρει σχηματίζουν έναν κύκλο αζιριδίνης, αζετιδίνης, πυρρολιδίνης, πιπεριδίνης ή μορφολίνης· οι ομάδες C3-7 κυκλοαλκυλ και φαινυλ έχουν υποκατασταθεί· ως βάση, άλας προσθήκης σε ένα οξύ, ένυδρο ή διαλύτη σε ένα οξύ ή ένα ένυδρο. Εφαρμογή σε θεραπευτική αγωγή.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0209061A FR2842523A1 (fr) | 2002-07-17 | 2002-07-17 | Derives d'acylaminothiazole, leur preparation et leur application en therapeutique |
EP03750801A EP1525193B1 (fr) | 2002-07-17 | 2003-07-11 | Derives d'acylaminothiazole et leur utilisation comme inhibiteurs de beta-amyloide |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1107903T1 true CY1107903T1 (el) | 2013-09-04 |
Family
ID=29797510
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20081100273T CY1107903T1 (el) | 2002-07-17 | 2008-03-07 | Παραγωγα ακυλαμινοθειαζολης και η χρηση τους ως αναστολεις του βητα-αμυλοειδους |
Country Status (14)
Country | Link |
---|---|
US (2) | US7291636B2 (el) |
EP (1) | EP1525193B1 (el) |
JP (1) | JP4680593B2 (el) |
AR (1) | AR040570A1 (el) |
AT (1) | ATE382040T1 (el) |
AU (1) | AU2003269018A1 (el) |
CY (1) | CY1107903T1 (el) |
DE (1) | DE60318317T2 (el) |
DK (1) | DK1525193T3 (el) |
ES (1) | ES2297198T3 (el) |
FR (1) | FR2842523A1 (el) |
PT (1) | PT1525193E (el) |
TW (1) | TWI313680B (el) |
WO (1) | WO2004009565A2 (el) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2842523A1 (fr) * | 2002-07-17 | 2004-01-23 | Sanofi Synthelabo | Derives d'acylaminothiazole, leur preparation et leur application en therapeutique |
WO2004033439A1 (en) * | 2002-10-09 | 2004-04-22 | Pfizer Products Inc. | Thiazole compounds for the treatment of neurodegenerative disorders |
SI1700856T1 (sl) * | 2003-12-26 | 2016-02-29 | Kyowa Hakko Kirin Co., Ltd., | Tiazolni derivat |
FR2873370B1 (fr) * | 2004-07-22 | 2006-10-20 | Sanofi Synthelabo | Derives d'acylaminothiazole, leur preparation et leur application en therapeutique |
FR2865206B1 (fr) * | 2004-01-16 | 2009-02-06 | Sanofi Synthelabo | Derives d'acylaminothiazole, leur preparation et leur application en therapeutique |
EP1709018B1 (fr) | 2004-01-16 | 2011-07-20 | Sanofi-Aventis | Derives d'acylaminothiazole et leur application comme inhibiteurs de beta-amyloide |
BRPI0506880A (pt) * | 2004-01-16 | 2007-06-26 | Sanofi Aventis | derivados de acilaminotiazol, sua preparação e sua aplicação em terapêutica |
US7384968B2 (en) | 2004-04-01 | 2008-06-10 | Pfizer Inc. | Thiazole-amine compounds for the treatment of neurodegenerative disorders |
US20050222227A1 (en) * | 2004-04-01 | 2005-10-06 | Pfizer Inc | Oxazole-amine compounds for the treatment of neurodegenerative disorders |
DE602005007912D1 (de) * | 2004-08-03 | 2008-08-14 | Chiesi Farma Spa | Derivate von 1-phenylalkancarbonsäuren zur behandlung von neurodegenerativen krankheiten |
CA2636077C (en) * | 2006-01-18 | 2012-01-03 | Amgen Inc. | Thiazole compounds as protein kinase b (pkb) inhibitors |
WO2007116901A1 (ja) * | 2006-04-05 | 2007-10-18 | Banyu Pharmaceutical Co., Ltd. | 新規アリールアミド誘導体 |
CN100415709C (zh) * | 2006-05-15 | 2008-09-03 | 西北大学 | β-(3,4-二羟基苯基)-α-羟基丙酸冰片酯、其合成方法和用途 |
DE102006048042A1 (de) * | 2006-10-11 | 2008-04-17 | Bayer Healthcare Ag | Acylaminoimidazole und Acylaminothiazole |
WO2009011880A2 (en) | 2007-07-17 | 2009-01-22 | Amgen Inc. | Heterocyclic modulators of pkb |
WO2009011871A2 (en) * | 2007-07-17 | 2009-01-22 | Amgen Inc. | Thiadiazole modulators of pkb |
EP2334643A1 (en) * | 2008-10-14 | 2011-06-22 | Actelion Pharmaceuticals Ltd. | Phenethylamide derivatives and their heterocyclic analogues |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3796800A (en) * | 1971-11-22 | 1974-03-12 | Uniroyal Inc | Anti-inflammatory triazole compositions and methods for using same |
FR2546520B1 (fr) * | 1983-05-27 | 1985-08-30 | Sanofi Sa | Nouveaux composes antibiotiques derives des cephalosporines |
US5712270A (en) * | 1995-11-06 | 1998-01-27 | American Home Products Corporation | 2-arylamidothiazole derivatives with CNS activity |
ID21956A (id) * | 1996-11-22 | 1999-08-19 | Elan Pharm Inc | Asam n-(aril dan atau heteroarilasetil) amino ester, komposisi farmasi yang mengandungnya, dan metoda untuk menghambat pelepasan betha-amiloid peptida dan atau sintesanya dengan menggunakan senyawa tersebut |
FR2842523A1 (fr) * | 2002-07-17 | 2004-01-23 | Sanofi Synthelabo | Derives d'acylaminothiazole, leur preparation et leur application en therapeutique |
WO2004033439A1 (en) * | 2002-10-09 | 2004-04-22 | Pfizer Products Inc. | Thiazole compounds for the treatment of neurodegenerative disorders |
-
2002
- 2002-07-17 FR FR0209061A patent/FR2842523A1/fr active Pending
-
2003
- 2003-07-11 AU AU2003269018A patent/AU2003269018A1/en not_active Abandoned
- 2003-07-11 JP JP2004522233A patent/JP4680593B2/ja not_active Expired - Fee Related
- 2003-07-11 DK DK03750801T patent/DK1525193T3/da active
- 2003-07-11 AT AT03750801T patent/ATE382040T1/de active
- 2003-07-11 WO PCT/FR2003/002194 patent/WO2004009565A2/fr active IP Right Grant
- 2003-07-11 PT PT03750801T patent/PT1525193E/pt unknown
- 2003-07-11 EP EP03750801A patent/EP1525193B1/fr not_active Expired - Lifetime
- 2003-07-11 ES ES03750801T patent/ES2297198T3/es not_active Expired - Lifetime
- 2003-07-11 DE DE60318317T patent/DE60318317T2/de not_active Expired - Lifetime
- 2003-07-15 AR AR20030102538A patent/AR040570A1/es unknown
- 2003-07-16 TW TW092119408A patent/TWI313680B/zh not_active IP Right Cessation
-
2005
- 2005-01-14 US US11/035,803 patent/US7291636B2/en not_active Expired - Fee Related
-
2007
- 2007-09-21 US US11/859,443 patent/US7795289B2/en not_active Expired - Fee Related
-
2008
- 2008-03-07 CY CY20081100273T patent/CY1107903T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
AR040570A1 (es) | 2005-04-13 |
PT1525193E (pt) | 2008-02-25 |
US7291636B2 (en) | 2007-11-06 |
AU2003269018A1 (en) | 2004-02-09 |
TW200413341A (en) | 2004-08-01 |
DE60318317D1 (de) | 2008-02-07 |
JP2005538086A (ja) | 2005-12-15 |
WO2004009565A3 (fr) | 2004-04-08 |
TWI313680B (en) | 2009-08-21 |
JP4680593B2 (ja) | 2011-05-11 |
FR2842523A1 (fr) | 2004-01-23 |
EP1525193B1 (fr) | 2007-12-26 |
WO2004009565A2 (fr) | 2004-01-29 |
DE60318317T2 (de) | 2009-07-09 |
EP1525193A2 (fr) | 2005-04-27 |
US20080051436A1 (en) | 2008-02-28 |
DK1525193T3 (da) | 2008-04-28 |
ATE382040T1 (de) | 2008-01-15 |
US7795289B2 (en) | 2010-09-14 |
ES2297198T3 (es) | 2008-05-01 |
US20050182104A1 (en) | 2005-08-18 |
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