PA8563601A1 - Acidos-3-(imidazolil)-2- alcoxipropanoicos - Google Patents
Acidos-3-(imidazolil)-2- alcoxipropanoicosInfo
- Publication number
- PA8563601A1 PA8563601A1 PA20038563601A PA8563601A PA8563601A1 PA 8563601 A1 PA8563601 A1 PA 8563601A1 PA 20038563601 A PA20038563601 A PA 20038563601A PA 8563601 A PA8563601 A PA 8563601A PA 8563601 A1 PA8563601 A1 PA 8563601A1
- Authority
- PA
- Panama
- Prior art keywords
- rent
- alcoxipropanoics
- imidazolil
- acids
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
LOS COMPUESTOS DE ACUERDO CON LA FORMULA (I) EN LA QUE N ES 1-4, R1 ESTA OPCIONALMENTE SUSTITUIDO CON ALQUILO C1-6, ALQUENILO C2-6 O ALQUINILO C2-6, HETEROCICLO, HETEROCICLO AROMATICO, ARILO O HIDROGENO Y CADA UNO DE R2, R3, R4, R5, R6, R7 Y R8 SE SELECCIONA INDEPENDIENTEMENTE ENTRE HIDROGENO Y UN GRUPO ALQUILO C1-6 OPCIONALMENTE SUSTITUIDO, SON NOVEDOSOS. ELLOS SON UTILES EN EL TRATAMIENTO DE AFECCIONES TROMBOTICAS Y OTRAS PATOLOGIAS ASOCIADAS CON EL DEPOSITO DE FIBRINA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0201387A GB0201387D0 (en) | 2002-01-22 | 2002-01-22 | 3-(imidazolyl)-2-aminopropanoic acids |
GB0201911A GB0201911D0 (en) | 2002-01-28 | 2002-01-28 | 3-(Imidazolyl)-2-Aminopropanoic acids |
Publications (1)
Publication Number | Publication Date |
---|---|
PA8563601A1 true PA8563601A1 (es) | 2003-12-10 |
Family
ID=27614791
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PA20038563601A PA8563601A1 (es) | 2002-01-22 | 2003-01-22 | Acidos-3-(imidazolil)-2- alcoxipropanoicos |
Country Status (11)
Country | Link |
---|---|
US (2) | US6759426B2 (es) |
EP (1) | EP1467732A1 (es) |
JP (1) | JP2005516972A (es) |
BR (1) | BR0307033A (es) |
CA (1) | CA2472239A1 (es) |
HN (1) | HN2003000040A (es) |
MX (1) | MXPA04005940A (es) |
PA (1) | PA8563601A1 (es) |
PE (1) | PE20030858A1 (es) |
TW (1) | TW200302093A (es) |
WO (1) | WO2003061653A1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2472239A1 (en) * | 2002-01-22 | 2003-07-31 | Pfizer Inc. | 3-(imidazolyl)-2-aminopropanoic acids for use as tafi-a inhibitors for the treatment of thrombotic diseases |
WO2004019882A2 (en) * | 2002-08-29 | 2004-03-11 | American Diagnostica, Inc. | METHODS OF SCREENING FOR COMPOUNDS THAT MODULATE TAFIa ACTIVITY, COMPOUNDS, AND METHODS OF USING THE COMPOUNDS |
DE102004020186A1 (de) | 2004-04-22 | 2005-11-17 | Aventis Pharma Deutschland Gmbh | Heterocyclylessigsäuren als Inhibitoren von TAFla |
US8710232B2 (en) | 2004-04-22 | 2014-04-29 | Sanofi-Aventis Deutschland Gmbh | Imidazole derivatives used as TAFIa inhibitors |
JP4046708B2 (ja) * | 2004-06-04 | 2008-02-13 | 明治製菓株式会社 | 3−アルケニルセフェム化合物の製造方法 |
JP2008515893A (ja) * | 2004-10-05 | 2008-05-15 | バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト | 肺線維症を処置するためのtafi阻害剤およびそれらの使用 |
CA2604912A1 (en) * | 2005-04-18 | 2006-10-26 | Bayer Schering Pharma Aktiengesellschaft | Use of tafi inhibitors for enhanced myocardial reperfusion and facilitated pci |
DE102005049385A1 (de) | 2005-10-15 | 2007-04-19 | Sanofi-Aventis Deutschland Gmbh | Imidazolderivate als Inhibitoren von TAFIa |
US20110213143A1 (en) | 2008-10-29 | 2011-09-01 | Taisho Pharmaceutical Co., Ltd. | Compound having tafia inhibitory activity |
AR078424A1 (es) * | 2009-09-17 | 2011-11-09 | Taisho Pharmaceutical Co Ltd | Derivados de dihidroimidazoquinolina con actividad inhibitoria de tafia, composiciones farmaceuticas que los contienen y su uso como agentes terapeuticos o profilacticos para enfermedades tromboticas |
ES2608779T3 (es) * | 2010-03-18 | 2017-04-17 | Daiichi Sankyo Company, Limited | Derivado de ácido ciclopropanocarboxílico |
DK2548871T3 (da) * | 2010-03-18 | 2017-11-06 | Daiichi Sankyo Co Ltd | Cycloalkylsubstitueret imidazolderivat |
WO2012062730A1 (en) | 2010-11-11 | 2012-05-18 | Sanofi | Process for the preparation of 3-(6-amino-pyridin-3yl)-2-acrylic acid derivatives |
WO2014198620A1 (en) | 2013-06-10 | 2014-12-18 | Sanofi | Macrocyclic urea derivatives as inhibitors of tafia, their preparation and their use as pharmaceuticals |
EP3437641A4 (en) | 2016-03-29 | 2019-11-20 | Daiichi Sankyo Company, Limited | THERAPEUTIC AGENT FOR INFLAMMATORY BOWEL DISEASES |
Family Cites Families (89)
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JPS6033439B2 (ja) * | 1980-03-07 | 1985-08-02 | 財団法人相模中央化学研究所 | ジペプチドの製造方法 |
IL68218A (en) * | 1983-03-23 | 1985-12-31 | Univ Ramot | Compositions for cartilage repair comprising embryonal chondrocytes |
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US4681763A (en) * | 1985-06-11 | 1987-07-21 | University Of Medicine And Dentistry Of New Jersey | Composition for stimulating bone growth |
GB8618374D0 (en) * | 1986-07-28 | 1986-09-03 | Hsc Res Dev Corp | Biological vascular prostheses |
US5041138A (en) * | 1986-11-20 | 1991-08-20 | Massachusetts Institute Of Technology | Neomorphogenesis of cartilage in vivo from cell culture |
CA1340581C (en) * | 1986-11-20 | 1999-06-08 | Joseph P. Vacanti | Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices |
US5736372A (en) * | 1986-11-20 | 1998-04-07 | Massachusetts Institute Of Technology | Biodegradable synthetic polymeric fibrous matrix containing chondrocyte for in vivo production of a cartilaginous structure |
US5306311A (en) * | 1987-07-20 | 1994-04-26 | Regen Corporation | Prosthetic articular cartilage |
US5354557A (en) * | 1988-04-08 | 1994-10-11 | Stryker Corporation | Osteogenic devices |
US5496722A (en) * | 1988-06-30 | 1996-03-05 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Method for producing non-neoplastic, three dimensional, mammalian tissue and cell aggregates under microgravity culture conditions and the products produced therefrom |
US5152791A (en) * | 1989-12-07 | 1992-10-06 | Olympus Optical Co., Ltd. | Prosthetic artificial bone having ceramic layers of different porosity |
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FR2664808A1 (fr) * | 1990-07-23 | 1992-01-24 | Gersberg Eduardo | Systeme d'implants dentaires. |
US5206023A (en) * | 1991-01-31 | 1993-04-27 | Robert F. Shaw | Method and compositions for the treatment and repair of defects or lesions in cartilage |
US6013853A (en) * | 1992-02-14 | 2000-01-11 | The University Of Texas System | Continuous release polymeric implant carrier |
US5326357A (en) * | 1992-03-18 | 1994-07-05 | Mount Sinai Hospital Corporation | Reconstituted cartridge tissue |
US5916265A (en) * | 1994-03-30 | 1999-06-29 | Hu; Jie | Method of producing a biological extracellular matrix for use as a cell seeding scaffold and implant |
US5723331A (en) * | 1994-05-05 | 1998-03-03 | Genzyme Corporation | Methods and compositions for the repair of articular cartilage defects in mammals |
US5906827A (en) * | 1994-06-03 | 1999-05-25 | Creative Biomolecules, Inc. | Matrix for the manufacture of autogenous replacement body parts |
US5516532A (en) * | 1994-08-05 | 1996-05-14 | Children's Medical Center Corporation | Injectable non-immunogenic cartilage and bone preparation |
US5632745A (en) * | 1995-02-07 | 1997-05-27 | R&D Biologicals, Inc. | Surgical implantation of cartilage repair unit |
US5769899A (en) * | 1994-08-12 | 1998-06-23 | Matrix Biotechnologies, Inc. | Cartilage repair unit |
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US5904716A (en) * | 1995-04-26 | 1999-05-18 | Gendler; El | Method for reconstituting cartilage tissue using demineralized bone and product thereof |
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US20020111695A1 (en) * | 1995-11-06 | 2002-08-15 | Mount Sinai Hospital Corporation | Reconstituted mineralized cartilage tissue |
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US5910315A (en) * | 1997-07-18 | 1999-06-08 | Stevenson; Sharon | Allograft tissue material for filling spinal fusion cages or related surgical spaces |
ATE220564T1 (de) * | 1997-08-14 | 2002-08-15 | Sulzer Innotec Ag | Zusammensetzung und vorrichtung zur reparatur von knorpelgewebe in vivo bestehend aus nanokapseln mit osteoinduktiven und/oder chondroinduktiven faktoren |
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US6090998A (en) * | 1997-10-27 | 2000-07-18 | University Of Florida | Segmentally demineralized bone implant |
US6197586B1 (en) * | 1997-12-12 | 2001-03-06 | The Regents Of The University Of California | Chondrocyte-like cells useful for tissue engineering and methods |
DE19803673A1 (de) * | 1998-01-30 | 1999-08-05 | Norbert M Dr Meenen | Biohybrider Gelenkflächenersatz |
US7045141B2 (en) * | 1998-02-27 | 2006-05-16 | Musculoskeletal Transplant Foundation | Allograft bone composition having a gelatin binder |
US6911212B2 (en) * | 1998-02-27 | 2005-06-28 | Musculoskeletal Transplant Foundation | Malleable putty and flowable paste with allograft bone having residual calcium for filling bone defects |
US6143293A (en) * | 1998-03-26 | 2000-11-07 | Carnegie Mellon | Assembled scaffolds for three dimensional cell culturing and tissue generation |
US20040044408A1 (en) * | 1998-04-08 | 2004-03-04 | Hungerford David S. | Cell-culture and polymer constructs |
US6734018B2 (en) * | 1999-06-07 | 2004-05-11 | Lifenet | Process for decellularizing soft-tissue engineered medical implants, and decellularized soft-tissue medical implants produced |
DE69911609T2 (de) * | 1998-07-13 | 2004-07-01 | University Of Southern California, Los Angeles | Verfahren zur beschleunigen den zuwachs und heilen von knochen und knorpel |
TR200200089T2 (tr) * | 1998-08-14 | 2002-06-21 | Verigen Transplantation Service International (Vtsi) Ag | Kondrosit hücre transplantasyonu için metodlar; enstrümanlar ve maddeler |
US6530956B1 (en) * | 1998-09-10 | 2003-03-11 | Kevin A. Mansmann | Resorbable scaffolds to promote cartilage regeneration |
WO2000017321A2 (en) * | 1998-09-18 | 2000-03-30 | Massachusetts Institute Of Technology | Use of growth factors and hormones for expansion of mammalian cells and tissue engineering |
EP1128838B1 (en) * | 1998-10-14 | 2008-07-02 | DePuy Spine, Inc. | Extracellular matrix containing gdf-5 for inducing or enhancing chondrogenesis |
US6727224B1 (en) * | 1999-02-01 | 2004-04-27 | Genetics Institute, Llc. | Methods and compositions for healing and repair of articular cartilage |
US6294187B1 (en) * | 1999-02-23 | 2001-09-25 | Osteotech, Inc. | Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same |
SE9901573D0 (sv) | 1999-05-03 | 1999-05-03 | Astra Ab | New compounds |
SE9901572D0 (sv) | 1999-05-03 | 1999-05-03 | Astra Ab | New compounds |
AR023819A1 (es) | 1999-05-03 | 2002-09-04 | Astrazeneca Ab | FORMULACIoN FARMACEUTICA, KIT DE PARTES Y UTILIZACION DE DICHA FORMULACION |
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WO2001087369A2 (en) * | 2000-05-12 | 2001-11-22 | Osteotech, Inc. | Osteoimplant and method for making same |
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DE19957388A1 (de) * | 1999-11-24 | 2001-06-13 | Michael Sittinger | Chondroinduktive und implantierbare Substrate zur Knorpelheilung und -protektion |
EP1498089A1 (de) * | 1999-12-15 | 2005-01-19 | Zimmer GmbH | Präparat für die Reparatur von Knorpel- oder Knorpel/Knochen-Defekten in menschlichen oder tierischen Gelenken |
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WO2001078798A1 (en) * | 2000-02-10 | 2001-10-25 | Regeneration Technologies, Inc. | Assembled implant |
US6626945B2 (en) * | 2000-03-14 | 2003-09-30 | Chondrosite, Llc | Cartilage repair plug |
AR027685A1 (es) * | 2000-03-22 | 2003-04-09 | Synthes Ag | Forma de tejido y metodo para realizarlo |
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DK177997B1 (da) * | 2000-07-19 | 2015-02-23 | Ed Geistlich Söhne Ag Für Chemische Ind | Knoglemateriale og collagenkombination til opheling af beskadigede led |
WO2002010348A2 (en) * | 2000-07-29 | 2002-02-07 | Smith & Nephew Plc | Tissue implant for cartilage repair |
CN1443173A (zh) * | 2000-08-17 | 2003-09-17 | 辉瑞大药厂 | 作为TAFIa抑制剂的取代的咪唑 |
DE10042484A1 (de) * | 2000-08-29 | 2002-03-28 | Merck Patent Gmbh | Verfahren zur Herstellung von humanen Knorpelimplantaten mittels in vitro gezüchteter Chondrozyten |
US20030050709A1 (en) * | 2001-02-23 | 2003-03-13 | Ulrich Noth | Trabecular bone-derived human mesenchymal stem cells |
US7252982B2 (en) * | 2001-03-15 | 2007-08-07 | Massachusetts Institute Of Technology | Tissue engineering enhanced by the transfer of a growth factor gene |
CA2441994C (en) * | 2001-03-23 | 2012-08-14 | Laurence J. Berlowitz Tarrant | Composition and methods for the production of biological tissues and tissue constructs |
CA2472239A1 (en) * | 2002-01-22 | 2003-07-31 | Pfizer Inc. | 3-(imidazolyl)-2-aminopropanoic acids for use as tafi-a inhibitors for the treatment of thrombotic diseases |
US6852331B2 (en) * | 2002-02-11 | 2005-02-08 | Taipei Biotechnology Ltd., Inc. | Fabrication of a cartilage implant |
US20040062753A1 (en) * | 2002-09-27 | 2004-04-01 | Alireza Rezania | Composite scaffolds seeded with mammalian cells |
US6761739B2 (en) * | 2002-11-25 | 2004-07-13 | Musculoskeletal Transplant Foundation | Cortical and cancellous allograft spacer |
US7067123B2 (en) * | 2003-04-29 | 2006-06-27 | Musculoskeletal Transplant Foundation | Glue for cartilage repair |
US7217294B2 (en) * | 2003-08-20 | 2007-05-15 | Histogenics Corp. | Acellular matrix implants for treatment of articular cartilage, bone or osteochondral defects and injuries and method for use thereof |
-
2003
- 2003-01-13 CA CA002472239A patent/CA2472239A1/en not_active Abandoned
- 2003-01-13 EP EP03700057A patent/EP1467732A1/en not_active Withdrawn
- 2003-01-13 MX MXPA04005940A patent/MXPA04005940A/es unknown
- 2003-01-13 JP JP2003561597A patent/JP2005516972A/ja not_active Withdrawn
- 2003-01-13 WO PCT/IB2003/000058 patent/WO2003061653A1/en not_active Application Discontinuation
- 2003-01-13 BR BR0307033-6A patent/BR0307033A/pt not_active IP Right Cessation
- 2003-01-16 TW TW092100892A patent/TW200302093A/zh unknown
- 2003-01-17 PE PE2003000057A patent/PE20030858A1/es not_active Application Discontinuation
- 2003-01-21 HN HN2003000040A patent/HN2003000040A/es unknown
- 2003-01-22 US US10/348,883 patent/US6759426B2/en not_active Expired - Fee Related
- 2003-01-22 PA PA20038563601A patent/PA8563601A1/es unknown
-
2004
- 2004-03-31 US US10/814,875 patent/US6919457B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
TW200302093A (en) | 2003-08-01 |
MXPA04005940A (es) | 2004-09-13 |
US20040192668A1 (en) | 2004-09-30 |
WO2003061653A9 (en) | 2003-12-24 |
PE20030858A1 (es) | 2003-10-21 |
HN2003000040A (es) | 2003-08-01 |
WO2003061653A1 (en) | 2003-07-31 |
US20030191107A1 (en) | 2003-10-09 |
JP2005516972A (ja) | 2005-06-09 |
US6919457B2 (en) | 2005-07-19 |
EP1467732A1 (en) | 2004-10-20 |
US6759426B2 (en) | 2004-07-06 |
CA2472239A1 (en) | 2003-07-31 |
BR0307033A (pt) | 2004-12-07 |
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